0 Bewertungen0% fanden dieses Dokument nützlich (0 Abstimmungen)
29 Ansichten3 Seiten
Mixed aldol reactions involve two different carbonyl compounds that can react to form up to four possible products. When an aldehyde with no α-hydrogens reacts with a ketone, generally only a single crossed-addition product is obtained in good yield since only the ketone can form an enolate. Preforming the ketone enolate before adding the aldehyde allows the desired crossed-aldol product to be obtained in high yield.
Mixed aldol reactions involve two different carbonyl compounds that can react to form up to four possible products. When an aldehyde with no α-hydrogens reacts with a ketone, generally only a single crossed-addition product is obtained in good yield since only the ketone can form an enolate. Preforming the ketone enolate before adding the aldehyde allows the desired crossed-aldol product to be obtained in high yield.
Mixed aldol reactions involve two different carbonyl compounds that can react to form up to four possible products. When an aldehyde with no α-hydrogens reacts with a ketone, generally only a single crossed-addition product is obtained in good yield since only the ketone can form an enolate. Preforming the ketone enolate before adding the aldehyde allows the desired crossed-aldol product to be obtained in high yield.