Stem cell lineage and identity

Zygote

Female Male germ cells

Primordial germ cells – Proacrosin
germ cells Teratome – PLAP – Tesmin
– STAT3 – Piwil2
– DDX4
– GDF9
– IFITM1
– IFITM2
– SYCP3

Spermatogonial
stem cells
Blastocyst

Trophectoderm
• CDX2
• EOMES Nervous Skin and Mammary
system hair gland
Ectoderm – Nestin – CD34 – Integrin β-1/
Inner cell – GFAP – Noggin – Integrin β-1 CD29
mass – Islet1 – Pax6 – Keratin 15 – CD24
– AP – Neurofilament – Sox2 – CD49f
– CD9 – Olig2
– GCTM2
– NANOG
– OCT4
– SOX2 Neural Bulge Mammary gland
– SSEA3 stem cells stem cells stem cells
– SSEA4
– Tra-1-60 Late blastocyst
– Tra-1-81

Epiblast Vascular cells

Mesoderm
– BMP4 Heart Muscle Mesenchyme Hematopoiesis
– CD31 – Cripto1 – ABCG2 – CD105 – CD34
– T-Brachyury – Islet1 – MyoD – CD73 – c-Kit
– LEF1 – MESP – Myf5 – CD90 – Sca1
– VEGFR2 – Pax7 – RUNX1

Trophectoderm
Heman-
gioblast
– VEGFR2
Cardiac Satellite Mesenchymal – GATA2 Hematopoietic
progenitors stem cells stromal cells – VE-Cadherin stem cells
– Tie2

Gastrula Endoderm
– FOXA2 Intestine Pancreas Liver Lungs
– GATA4 – Musashi 1 – CK19 – a-fetoprotein – β-Catenin
– GATA6 – Wnt/ – Insulin – Albumin – LEF1
– HNF4a Notch/ – PDX1 – Integrin β-1 – Sca1
– SOX17 BMP – Hes1
pathway

Crypt Pancreas-derived Lung

multipotent Oval cells
stem cells precursors stem cells

www.abcam.com

Copyright © 2017 Abcam, All rights reserved.

Stem cell lineage and identity

Zygote

Female Male germ cells

Primordial germ cells – Proacrosin
germ cells Teratome – PLAP – Tesmin
– STAT3 – Piwil2
– DDX4
– GDF9
– IFITM1
– IFITM2
– SYCP3

Spermatogonial
stem cells
Blastocyst

Trophectoderm
• CDX2
• EOMES Nervous Skin and Mammary
system hair gland
Ectoderm – Nestin – CD34 – Integrin β-1/
Inner cell – GFAP – Noggin – Integrin β-1 CD29
mass – Islet1 – Pax6 – Keratin 15 – CD24
– AP – Neurofilament – Sox2 – CD49f
– CD9 – Olig2
– GCTM2
– NANOG
– OCT4
– SOX2 Neural Bulge Mammary gland
– SSEA3 stem cells stem cells stem cells
– SSEA4
– Tra-1-60 Late blastocyst
– Tra-1-81

Epiblast Vascular cells

Mesoderm
– BMP4 Heart Muscle Mesenchyme Hematopoiesis
– CD31 – Cripto1 – ABCG2 – CD105 – CD34
– T-Brachyury – Islet1 – MyoD – CD73 – c-Kit
– LEF1 – MESP – Myf5 – CD90 – Sca1
– VEGFR2 – Pax7 – RUNX1

Trophectoderm
Heman-
gioblast
– VEGFR2
Cardiac Satellite Mesenchymal – GATA2 Hematopoietic
progenitors stem cells stromal cells – VE-Cadherin stem cells
– Tie2

Gastrula Endoderm
– FOXA2 Intestine Pancreas Liver Lungs
– GATA4 – Musashi 1 – CK19 – a-fetoprotein – β-Catenin
– GATA6 – Wnt/ – Insulin – Albumin – LEF1
– HNF4a Notch/ – PDX1 – Integrin β-1 – Sca1
– SOX17 BMP – Hes1
pathway

Crypt Pancreas-derived Lung

multipotent Oval cells
stem cells precursors stem cells

www.abcam.com

Copyright © 2017 Abcam, All rights reserved.