Patient/Problem: teenagers with acne vulgaris

Intervention: retinoids therapy

Comparison: topical antibiotics
Outcome:sides effect

My question : In teenagers with acne vulgaris , retinoids

therapy is more effective than topical antibiotics ?

PubMed: (((acne vulgaris[MeSH Terms]) AND teenagers)) AND "drug therapy"[MeSH

Subheading] - 2229 items found

TripDataBase: 62 results for

(teenagers)(retinoids therapy)(topical antibiotic)(sides effect)

Efficacy of photodynamic therapy combined with

minocycline for treatment of moderate to severe
facial acne vulgaris and influence on quality of life.
BACKGROUND:
Acne vulgaris is a prevalent skin disorder impairing both physical and
psychosocial health. This study was designed to investigate the effectiveness of
photodynamic therapy (PDT) combined with minocycline in moderate to severe
facial acne and influence on quality of life (QOL).
METHODS:
Ninety-five patients with moderate to severe facial acne (Investigator Global
Assessment [IGA] score 3-4) were randomly treated with PDT and minocycline
(n = 48) or minocycline alone (n = 47). All patients took minocycline hydrochloride
100 mg/d for 4 weeks, whereas patients in the minocycline plus PDT group also
received 4 times PDT treatment 1 week apart. IGA score, lesion counts,
Dermatology Life Quality Index (DLQI), and safety evaluation were performed
before treatment and at 2, 4, 6, and 8 weeks after enrolment.
RESULTS:
There were no statistically significant differences in characteristics between 2
treatment groups at baseline. Minocycline plus PDT treatment led to a greater
mean percentage reduction from baseline in lesion counts versus minocycline
alone at 8 weeks for both inflammatory (-74.4% vs -53.3%; P < .001) and
noninflammatory lesions (-61.7% vs -42.4%; P < .001). More patients treated with
minocycline plus PDT achieved IGA score <2 at study end (week 8: 30/48 vs
20/47; P < .05). Patients treated with minocycline plus PDT got significant lower
DLQI at 8 weeks (4.4 vs 6.3; P < .001). Adverse events were mild and
manageable.

CONCLUSIONS:
Compared with minocycline alone, the combination of PDT with minocycline
significantly improved clinical efficacy and QOL in moderate to severe facial acne
patients.

Bibliography :
Xu X, Zheng Y, Zhao Z, Zhang X, Liu P, Li C. Medicine (Baltimore). 2017 Dec;96(51):e9366. doi:
10.1097/MD.0000000000009366
Department of Dermatology.
Department of Neurosurgery, Chinese PLA General Hospital.
Department of Dermatology, Beijing Chao-yang Hospital, Capital Medical University, Beijing,
China.