Hormonal Relationships

Under the primary influence of estrogens from the maturing ovary at puberty,
the ductal cells proliferate and form branches.
After ovulation, progesterone from the corpus luteum, an organ that develops
in the ovary each time an ovum has been shed and has the function of
preparing the uterus for receiving the developing embryo, causes the terminal
ductal cells to differentiate into the milk-producing cells, which form acini.
Interspersed with these cells are smooth muscle cells, which can contract and
assist in the ejection of milk. The acini are collapsed or filled with
desquamated epithelium (epithelium that has been shed), until the stimulus
of pregnancy causes proliferation of all the epithelial cells. The breast
becomes enlarged, tense, and sensitive, and the areola widened and more
deeply pigmented. The actual secretion of milk is induced by hormones—
prolactin from the pituitary and somatomammotropin from the placenta. At the
end of lactation the mammary glands and areolae return almost but not
completely to their state before pregnancy. After menopause the glands
atrophy and are largely replaced by connective tissue and fat.
Diseases and abnormalities of the breast. The occurrence of supernumerary
breasts and nipples has been mentioned. Absence of one or both breasts
occurs, but rarely. Inequality in size is frequent, the left breast being larger
more often than the right. Variations in size and shape are commonly of racial
or genetic origin, but may be induced by a tight-fitting garment or by
manipulation to cause elongation for the greater convenience of nursing an
infant carried on the back.
Painful breasts may occur whenever estrogens are present in large amounts,
as at puberty, during pregnancy, prior to menstruation, or after administration
of the estrogens.

Fibrocystic disease, also called chronic cystic mastitis, may result in later
reproductive life from the cumulative effect of the ebb and flow of endocrine
stimulation with each menstrual cycle; this produces nodular fibrosis—or
lumps of fibrous tissue—and cysts of various sizes. The condition can usually
be distinguished from cancer because it is intermittently painful and tends to
subside after menstrual periods. It may predispose to carcinoma, however.
Early biopsy is indicated for any nodules that persist.
Endocrine disorders may cause precocious breast development
or gynecomastia (enlargement of the breast in the male). Gynecomastia may
also be an indication of a sex chromatin abnormality called Klinefelter’s
syndrome.
The only common infectious disease unique to the breast is acutemastitis,
which occurs during lactation as the result of an invasion of pyogenic skin
organisms through the nipple. The severe local inflammation, with high fever
and prostration, responds promptly to antibiotics, usually without suppuration.
Mastitis is ordinarily prevented by proper hygiene.
Benign tumours include fibroadenoma, more common in women under 30,
and intraductal papilloma, which may cause bleeding from the nipple. These
tumours should be removed. Malignant tumours may arise from any of the cell
types contained in the breast, but sarcomas make up only 3 percent of all
breast tumours.
Carcinoma of the female breast is the commonest form of malignant tumour in
the Western world, afflicting about 4 percent of all adult women. Rare under
the age of 25, it increases in incidence up to menopause and then levels off.
Hereditary factors play a role, but their exact importance has not been clearly
established.