(3)Glasier, A., & Gebbie, A. (2017). Family Planning/Contraception.

International
Encyclopedia Of Public Health, 92–101. Doi:10.1016/B978-0-12-803678-5.00155-7

Handayani Sri. 2010. Buku Ajar Pelayanan Keluarga Berencana. Jakarta : Pustaka Rihama

Hartanto, H. 2004. Keluarga Berencana Dan Kontrasepsi.Jakarta : Pustaka Sinar Harapan

(4) Saifuddin, Abdul Bari. (2006). Buku Panduan Praktis Pelayanan Kontrasepsi. Jakarta :
Penerbit Yayasan Bina Pustaka Sarwono.

(2)Data Badan Kependudukan Dan Keluarga Berencana Nasional (Bkkbn) Tahun 2014

(5) Device-Assisted Transdermal Drug Delivery

Hyunjae Lee A,1, Changyeong Song A,B,1, Seungmin Baik A,B,1, Dokyoon Kima,
Taeghwan Hyeon A,B,⁎, Dae-Hyeong Kima,B,⁎ Advanced Drug Delivery Reviews 127
(2018) 35–45

(6) Agrawal, S. S., & Pruthi, J. K. (2011). Development And Evaluation Of Matrix Type
Transdermal Patch Of Ethinylestradiol And Medroxyprogesterone Acetate For Anti-
Implantation Activity In Female Wistar Rats. Contraception, 84(5), 533–538.

(7) Ultra-Adaptable Nanovesicular Systems:

A Carrier For Systemic Delivery Of
Therapeutic Agents
Ajay Kumar, Kamla Pathak And Vikas Bali
Department, 2007

(9) Sharma, A. Et Al. (2010) Recent Advances In Ndds (Novel Drug Delivery Systems) For
Delivery Of Anti-Hiv Drugs. Res. J Pharm. Bio. Chem. Sci. 1, 78–88
(10)Cevc, G. (2002) Self- Regulating Smart Carriers For Non-Invasive And Targeted Drug
Delivery. Cell. Mol. Biol. Lett. 7, 224–225

11. Cevc, G.; Blume, G.; Schatzlein, A. Transfersomes Mediated Transepidermal Delivery
Improves The Regiospecificity And Biological Activity Of Corticosteriods In Vivo. J.
Control Rel. 1997, 45, 211–226.

(8) Jain, S., Jain, P., Umamaheshwari, R. B., & Jain, N. K. (2003). Transfersomes—A Novel
Vesicular Carrier For Enhanced Transdermal Delivery: Development,
Characterization, And Performance Evaluation. Drug Development And Industrial
Pharmacy, 29(9), 1013–1026. Doi:10.1081/Ddc-120025458

Trussell, J., 2004. Contraceptive Efficacy. In: Hatcher, R.A., Trussell, J., Stewart, F.,
Et Al. (Eds.), Contraceptive Technology, Eighteenth Revised Ed. Ardent Media, New
York, Pp. 773–845.
Edelman A, Micks E, Gallo Mf, Et Al: Continuous Or Extended Cycle Vs. Cyclic Use Of
Combined Hormonal Contraceptives For Contraception. In Micks E, Editor: Cochrane
Database Of Systematic Reviews, Chichester, Uk, 2014, John Wiley & Sons, Ltd.

Mishell Dr Jr, Kharma Km, Thorneycroft Ih, Nakamura Rm: Estrogenic Activity In Women
Receiving An Injectable Progestogen For Contraception. Am J Obstet Gynecol
113(3):372–376, 1972.
121. Siriwongse T, Snidvongs W, Tantayaporn P, Et Al: Effect Of Depo-
Medroxyprogesterone Acetate On Serum Progesterone Levels When Administered On
Various Cycle Days. Contraception 26(5):487–493, 1982.

Ortiz A, Hiroi M, Stanczyk Fz, Et Al: Serum Medroxyprogesterone Acetate (Mpa)

Concentrations And Ovarian Function Following Intramuscular Injection Of Depo-Mpa. J
Clin Endocrinol Metab 44(1):32–39, 1977.
123. Fotherby K, Koetsawang S, Mathrubuthan M: Pharmacokinetic Study Of Different
Doses Of Depo Provera. Contraception 22(5):527–536, 1980.
124. Kirton Kt, Cornette Jc: Return Of Ovulatory Cyclicity Following An Intramuscular
Injection Of Medroxyprogesterone Acetate (Provera). Contraception 10(1):39–45, 1974.
125. Westhoff C: Depot Medroxyprogesterone Acetate Contraception. Metabolic
Parameters And Mood Changes. J Reprod Med 41(5 Suppl):401–406, 1996.
126. Upadhyay Ud, Zlidar Vm, Foster Dg: Interest In Self-Administration Of
Subcutaneous Depot Medroxyprogesterone Acetate In The United States. Contraception
94(4):303–313, 2016.
127. Multinational Comparative Clinical Evaluation Of Two Long-Acting Injectable
Contraceptive Steroids: Noresthisterone Oenanthate And Medroxyprogesterone
Acetate. 2. Bleeding Patterns And Side Effects. Contraception 17:395–406, 1978.

Donnelly, Ryan F._ Singh, Thakur Raghu Raj - Novel Delivery Systems For Transdermal
And Intradermal Drug Delivery :Advances In Pharmaceutical Technology (2015, John
Wiley And Sons)

[] Suryakanta Swain, Chinam Niranjan Patra, M. E. Bhanoji Rao - Pharmaceutical Drug

Delivery Systems And Vehicles Woodhead Publishing India In Medicine (2015, Wpi
Publishing)

[Drugs And The Pharmaceutical Sciences] Thassu Deepak, Michel Deleers, Yashwant
Vishnupant Pathak - Nanoparticulate Drug Delivery Systems (2007, Informa Healthcare)

[Drugs And The Pharmaceutical Sciences] Hadgraft, Jonathan - Transdermal Drug Delivery
Systems_ Revised And Expanded (2002, Crc Press) Gel, Kadang-Kadang Disebut Jeli,
Merupakan
Sistem Semipadat Terdiri Dari Suspensi Yang Dibuat Dari
Partikel Anorganik Yang Kecil Atau Molekul Organik
Yang Besar, Terpenetrasi Oleh Suatu Cairan.

9. Florence At, Attwood D. Fasttrack: Physical Pharmacy. Pharmaceutical Press, London,

Uk, 2007.

7. Labarre D, Ponchel G, Vauthier C. Biomedical And Pharmaceutical Polymers.

Pharmaceutical Press, London, Uk, 2010.

4. Jain Nk. Pharmaceutical Product Development. Cbs Publishers & Distributors, New Delhi,
2006

Pharmaceutical Gels: A Review Syeda Ayesha Ahmed Un Nabi, Muhammad Ali Sheraz*,
Sofia Ahmed, Nafeesa Mustaan, Iqbal Ahmad, 2016

Erawati, T., Rosita, N.,

Hendroprasetyo, W., Dan Juwita, D.
R., 2005, Pengaruh Jenis Basis Gel
Dan Penambahan Nacl (0.5% -B/B)
Terhadap Intensitas Echo Gelombang
Ultrasonik Sediaan Gel Untuk
Pemeriksaan Usg (Acoustic Coupling
Agent). Airlangga Journal Of
Pharmacy,

Raymond C R, Paul J S, M. E. Q. (2009). Handbook Of Pharmaceutical Excipients, Sixth

Edition, 549–553. Usa. Pharmaceutical Press.
Benson, H. A. (2006). Transfersomes For Transdermal Drug Delivery. Expert Opinion On
Drug Delivery, 3(6), 727–737.Doi:10.1517/17425247.3.6.727
Gupta Pn, Mishra V, Rawat A Et Al.: Non-Invasive Vaccine Delivery In Transfersomes,
Niosomes And Liposomes: A Comparative Study. Int. J. Pharm. (2005) 293(1-2):73-82

Cevc G, Blume G: New, Highly Efficient Formulation Of Diclofenac For The Topical, Transdermal
Administration In Ultradeformable Drug Carriers, Expert Opin. Drug Deliv. Downloaded From
Informahealthcare.Com By Universitaets- Und Landesbibliothek Duesseldorf On 03/17/13 For
Personal Use Only. Transfersomes For Transdermal Drug Delivery 736 Expert Opin. Drug Deliv.
(2006) 3(6) Transfersomes. Biochim. Biophys. Acta. (2001) 1514(2):191-205.

Shingade, G. (2012). Review On: Recent Trend On Transdermal Drug Delivery System. Journal Of Drug Delivery
And Therapeutics, 2(1). Https://Doi.Org/10.22270/Jddt.V2i1.74

Rizwan M, Aqil M, Talegoankar S, Azeem A, Sultana Y, Ali A. Enhanced Transdermal Drug Delivery
Techniques: An Extensive Review On Patents. Recent Pat Drug Deliv&Formul. 2009, 3(2):105-24.

Trotta M, Peira E, Carlotti Me, Gallarate M: Deformable Liposomes For Dermal Administration Of
Methotrexate. Int. J. Pharm. (2004) 270(1-2):119-125.

Essa Ea, Bonner Mc, Barry Bw: Electroporation And Ultradeformable Liposomes; Human Skin Barrier
Repair By Phospholipid. J. Control. Release (2003) 92(1-2):163-172.
 Han I, Kim M, Kim J: Enhanced Transfollicular Delivery Of Adriamycin With A Liposome And
Iontophoresis. Exp. Dermatol. (2004) 13(2):86-92.

Gupta Pn, Mishra V, Rawat A Et Al.: Non-Invasive Vaccine Delivery In Transfersomes, Niosomes And
Liposomes: A Comparative Study. Int. J. Pharm. (2005) 293(1-2):73-82.

Michaels As, Chandrasekaran Sk, Shaw Je: Drug Permeation Through Human Skin: Theory And In
Vitro Experimental Measurement. Aiche (1975) 21:985-996

Schatzlein A, Cevc G: Non-Uniform Cellular Packing Of The Stratum Corneum And Permeability
Barrier Function Of Intact Skin: A High-Resolution Confocal Laser Scanning Microscopy Study Using
Highly Deformable Vesicles (Transfersomes). Br. J. Dermatol. (1998) 138(4):583-592. 64.

Honeywell-Nguyen Pl, De Graaff Am, Wouter Groenink Hw, Bouwstra Ja: The In Vivo And In Vitro
Interactions Of Elastic And Rigid Vesicles With Human Skin. Biochim. Biophys. Acta (2002)
1573(2):130-140.

1. Modi CD and Bharadia PD: Transfersomes: New dominants for transdermal drug delivery. American
Journal of Pharmaceutical Technology 2012; 2(3): 71-91.
2. Prajapati ST, Patel CG and Patel CN: Transfersomes: A vesicular carrier system for transdermal drug
delivery. Asian Journal of Biochemical and Pharmaceutical research 2011; 1(2): 507-24.
3. Kombath RV, Minumula SK, Sockalingam A, Subadhra S, Parre S, Reddy TR, et al., Critical issues
related to transfersomes- novel vesicular system.Acta Scientiarum Polonorum Technologia
Alimentaria 2012; 1(11): 67-82.
4. Swarnlata S, Gunjan J, Chanchal DK and Shailendra S: Development of novel herbal cosmetic cream
with Curcuma longa extract loaded transfersome for anti-wrinkle effect.African Journal of Pharmacy
and Pharma-cology 2011; 5(8): 1054-62.
5. Schatzlein A and Cevc G: Skin penetration by phospho-lipid vesicles, Transfersomes as visualised by
means of Confocal Scanning Laser Microscopy, in characterization, metabolism and novel biological
applications. Champaign, American Oil Chemist's Society Press, 1995; 191-209.
6. Cevc G: Isothermal Lipid Phase Transitions Chemistry and Physics of Lipids 1991; 57: 293-99.
7. Jain S and Jain NK: Transfersomes: a novel carrier for effective transdermal drug delivery, advances
in controlled and novel drug delivery, , Prof. Jain NK, CBS publishers and Distributors, Chapter 18,
2001; 426-51.
8. Panchagnula R: Transdermal delivery of drugs. Indian Journal of Pharmacology1997; 29: 140-56.
9. Bain KR, Hadgkraft AJ, James WJ and Water KA: R. Prediction of percutaneous penetration Cardiff.
STS Publishing, 1993; 3b: 226-34.
10. Cevc G, Blume G and Schazlein: Transfersomes mediates transepidermal delivery immproves the
regiospecificity and biological activity of corticosteroids in-vivo.Journal of Controlled Release 1997;
45: 211-26.
11. Gamal M, EI Maghraby M, Williams AC and Barry BW: Skin delivery of oestrdiiol from deformable and
traditional liposomes. Journal of Pharmacy and Pharmacology 1999; 51(10): 1123-34.
12. Planas ME, Gonzalez P, Rodriguez S, Sanchez G and Cevc G: Noninvasive percutaneous induction
of topical analgesia by a new type of drug carrier, and prolongation of local pain insensitivity by
anesthetic liposomes. Anesthesia and Analgesia 1992; 75(4): 615-21.
13. Schatzlein A and Cevc G: Non-uniform cellular packing of the stratum corneum and permeability
barrier function of intact skin: a high-resolution confocal laser scanning microscopy study using highly
deformable vesicles (Transfersomes). British Journal of Dermatology 1998; 138(4): 583-98.
14. Shashank J, Niketkumar P, Mansi KS, et al., Recent advances in lipid-based vesicles and particulate
carriers for topical and transdermal application. J Pharm Sci. 2016; 116: 1-
15. Walve JR, Bakliwal SR, Rane BR and Pawar SP: Transfersomes: a surrogated carrier for transdermal
drug delivery system. Internation Journal of Applied Biology and Pharmaceutical Technology 2011;
2(1): 204-13.
16. Jain CP, Vyas SP and Dixit VK: Niosomal system for delivery of rifampicin to lymphatics. International
Journal of Pharmaceutics 2006; 68(5): 57-8.
17. Elsayed MMS, Abdallah OY and Nagar VF: Deformable liposomes and ethosomes: Mechanism of
enhanced skin delivery. International Journal of Pharmaceutics 2006; 322(1-2): 60-6.
18. Patel R, Singh SK, Singh S, Sheth NR and Gendle R: Development and characterisation of curcumin
loaded transfersome for enhanced skin delivery. Journal of Pharmaceutical Sciences and Research
2009; 1(4): 71-80.
19. Sheo DM, Shweta A, Vijay KT, Ram CD, Aklavya S and Ghansyam M: Enhanced transdermal
delivery of indinavir sulfate via Pharmacie Globale: International Journal of Comprehensive
Pharmacy2005; 5(9): 395.
20. Sheo DM, Shweta A, Ram CD, Ghanshyam M, Girish K and Sunil KP: Transfersomes- A novel
vesicular carrier for enhanced transdermal delivery of stavudine: Development, characterization and
performance evaluation. Journal of Scientific Speculations and Research 2010; 1(1): 30-6.
21. Charcosset C, Juban A, Valour J, et al., Preperation of liposomes at large scale using ethanol
injection method: effect of scale up and injection devices. Chem Eng Res Des. 2015; 94: 508-515.
22. Berge vanden BAI, Wertz PW, Junginger HE and Bouwstra JA: Elasticity of vesicles assesed by
electron spin resonance, electron microscopy and extrusion measurement. International Journal of
Pharmaceutics 2001; 217(1-2): 13-24.
23. Kombath RV, Minumula SK, Sockalingam A, Subadhra S, Parre S, Reddy TR, et al., Critical issues
related to transfersomes- novel vesicular system. Acta Scientiarum Polonorum Technologia
Alimentaria 2012; 11(1): 67-82.
24. Gavali MS, Pacharane SS, Jadhav RK and Kadam JV: Transferosome: A new technique for
transdermal drug delivery. International Journal of Research in Pharmacy and
Chemistry2011; 1(3): 735-40.
25. Schatzlein A and Cevc G: Skin penetration by phospho-lipid vesicles. Transfersomes as visualized by
means of the confocal scanning laser microscopy in characterisation, metabolism and novel biological
appication. American Oil Chemist's Society Press 1995; 191-209.
26. Planas ME, Gonzalez P, Rodriguex S, Sanchez G and Cevc G: Non invasive Percutaneous induction
of Topical Analgesia by a new type of drug carrier, and prolongation of local pain insensitivity by
anesthetic liposomes. Anesthesia and Analgesia 1992; 95: 615-21.
27. Laxmi MV and Zafaruddin MD: Design and charac-terization of transferosomal gel of repaglinide. Int
Res J Pharm 2015; 6: 38-42.
28. Malakar J, Sen SO, Nayak AK and Sen KK: Formulation, optimization and evaluation of
transfersomal gel for transdermal insulin delivery. Saudi Pharmaceutical Journal 2012; 20(4): 355-63.
29. Cevc G and Blume G: Hydrocortisone and dexamethasone in very deformable drug carriers have
increased biological potency, prolongd effect and reduced therapeutic dosage. Biochimica et
Biophysica Acta 2004; 1663(1-2): 61-73.
30. Maghraby EI, Williams GM and Barry BW: Skin delivery of oestradiol from lipid vesicles:importance of
liposome structure. International Journal of Pharmaceutics; 204(1-2): 159-69.
31. Trotta M, Peira E, Carlotti ME and Gallarate M: Deformable liposomes for dermal administration of
methotrexate. International Journal of Pharmaceutics 2004; 270: 119-25.
32. Hafer C, Goble R, Deering P, Lehmer A and Breut J: Formulation of interleukin-2 and interferon-alpha
con-taining ultra-deformable carriers for potential transdermal application. Anticancer Research 1999;
19(2c): 1505-07.
33. Benson HA: Transfersomes for transdermal drug delivery. Expert opinion on Drug Delivery 2006; 3(6):
727-37.
34. Khan Ma, Pandit J, Sultana Y,Sultana S, Ali A, Aqil M and Chauhan M: Novel carbopol-based
transfersomal gel of 5-fluorouracil for skin cancer treatment: in-vitro chracterisation and in-vivo Drug
Delivery. 2015; 22(6): 795-802.
35. Planas ME, Gonzalez P, Rodriguez L, Samchez S, Cevc G: Non invasive percutaneous induction of
topical analgesia by a new type of drug carrier and prolongation of local pain insensitivity by
anaesthetic liposomes. Anesthesia Analgesia 1992; 75(4): 61-72.
36. Shaji J and Lal M: Preparation, optimization and evaluation of transferosomal formulation for
enhanced transdermal delivery of a COX-2 inhibitor. Int J Pharm Pharm Sci 2014; 6: 467-77.
37. Nagaswamy D, Kalyani K, Tulasi K, Priyanka VS, Abid Ali SK and Kiran HC: Transfersomes: A novel
technique for transdermal drug delivery.International Journal of Research in Pharmaceutical and
Nano Sciences 2014; 3(4): 266-76.
38. Chen J, Lu WL, Lu SS, Chen ZP and Cai BC: Skin permeation of elastic liposomes:role of formulation
ingredients. Expert Opinion on Drug Delivery 2013; 10(6): 845-56.
39. Song CK, balakrishnan P, Shim CK, Chung SJ, Chong S and Kim DD: A novel vesicular carrier,
transethosome, for enhanced skin delivery of voriconazole: charac-terization and in-vitro in-
vivo Colloids and Surfaces B Biointerfaces 2012; 92: 299-304.
40. Ascenso A, Raposo S, Batista C, Cardoso P, Mendes T, Praça FG, et al., Development,
characterisation and skin delivery studies of related ultradeformable vesicles: trans-fersomes,
ethosomes and transethosomes. International Journal of Nanomedicine 2015; 10: 5837-51.

Shrimanker, K., Saxena, B. N., & Fotherby, K. (1978). A radioimmunoassay for serum
medroxyprogesterone acetate. Journal of Steroid Biochemistry, 9(4), 359–363. doi:10.1016/0022-
4731(78)90631-3

Rossi, E., De Pascale, A., Negrini, P., Frigerio, A., & Castegnaro, E. (1979). Quantitative gas—liquid
chromatographic determination of medroxyprogesterone acetate in human plasma. Journal of
Chromatography A, 169, 416–421.doi:10.1016/0021-9673(75)85

Milano, G., Carle, G., Renée, N., Boublil, J. L., & Namer, M. (1982). Determination of medroxyprogesterone
acetate in plasma by high-performance liquid chromatography. Journal of Chromatography B: Biomedical
Sciences and Applications, 232(2), 413–417. doi:10.1016/s0378-4347(00)84182-1

Dikkeschei, L. D., Van Veelen, H., Nagel, G. T., Willemse, P. H. B., & Wolthers, B. G. (1985). Specific and
sensitive determination of medroxyprogesterone acetate in human serum by gas chromatography mass
spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications, 345, 1–
10. doi:10.1016/0378-4347(85)80129-8

Formulasi dan Uji Penetrasi In Vitro Sediaan Gel Transfersom

Mengandung Kofein sebagai Antiselulit
(Formulation and In Vitro Penetration Evaluation of
Transfersome Gel Preparation Contains Caffeine as an
Anticellulite)
RINI SUGIYATI1,2, ISKANDARSYAH1, JOSHITA DJAJADISASTRA1