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Vaccine storage units must be selected carefully and used properly. A combination
refrigerator/freezer unit sold for home use is acceptable for vaccine storage if the
refrigerator and freezer compartments each have a separate door. However, vaccines
should not be stored near the cold air outlet from the freezer to the refrigerator. Many
combination units cool the refrigerator compartment by using air from the freezer
compartment. In these units, the freezer thermostat controls freezer temperature while
the refrigerator thermostat controls the volume of freezer temperature air entering the
refrigerator. This can result in different temperature zones within the refrigerator.
Temperature Monitoring
All medical care providers who administer vaccines should evaluate their cold chain
maintenance and management to ensure that 1) designated personnel and backup
personnel have written duties and are trained in vaccine storage and handling; 2)
accurate thermometers are placed properly in all vaccine storage units and any
limitations of the storage system are fully known; 3) vaccines are placed properly
within the refrigerator or freezer in which proper temperatures are maintained; 4)
temperature logs are reviewed for completeness and any deviations from
recommended temperature ranges; 5) any out-of-range temperatures prompt
immediate action to fix the problem, with results of these actions documented; 6) any
vaccines exposed to out-of-range temperatures are marked "do not use" and isolated
physically; 7) when a problem is discovered, the exposed vaccine is maintained at
proper temperatures while state or local health departments, or the vaccine
manufacturers, are contacted for guidance; and 8) written emergency retrieval and
storage procedures are in place in case of equipment failures or power outages.
Around-the-clock monitoring systems might be considered to alert staff to after-hours
emergencies, particularly if large vaccine inventories are maintained.
References
1. CDC. General recommendations on immunization: recommendations of the
Advisory Committee on Immunization Practices (ACIP) and the American
Academy of Family Physicians (AAFP). MMWR 2002;51(No. RR-2).
2. Gazmararian JA, Oster NV, Green DC, et al. Vaccine storage practices in
primary care physician offices. Am J Prev Med 2002;23:246--53.
3. Bell KN, Hogue CJ, Manning C, Kendal AP. Risk factors for improper vaccine
storage and handling in private provider offices. Pediatrics 2001;107:E100.
4. World Health Organization. Thermostability of vaccines. Geneva, Switzerland:
World Health Organization, 1998; publication no. WHO/GPV/98.07. Available
at http://www.who.int/vaccines-documents/DocsPDF/www9661.pdf.
5. World Health Organization. Temperature monitors for vaccines and the cold
chain. Geneva, Switzerland: World Health Organization, 1999; publication no.
WHO/V&B/99.15. Available at http://www.who.int/vaccines-
documents/DocsPDF/www9804.pdf.
6. Commonwealth Department of Health and Aged Care. Keep it cool: the
vaccine cold chain. Guidelines for immunisation providers on maintaining the
cold chain, 2nd ed. Canberra, Australia: Commonwealth of Australia, 2001.
Table 1
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Table 2
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