Hormone receptors and their effector systems

G protein-coupled receptors Catalytic receptors* Channel-linked

receptors*

Adenylate Cyclase (nicotinic) Tyrosine Kinase Acetylcholine

Luteinizing hormone (LH)/human Insulin (γ-aminobutyric acid)

chorionic gonadotropin (hCG)
Insulin-like growth factor Glycine
1/somatomedin C

Follicle-stimulating hormone Epidermal growth

(FSH) factor/transforming growth
factor-α

Glutamate/N-methyl-D-aspartate

Thyrotropin (TSH)

Corticotropin Colony-stimulating factor-1

β-Adrenergic catecholamines (β1 , Fibroblast growth factor

β2)

α2-Adrenergic catecholamines Platelet-derived growth

(inhibition) factor

Interleukins-2, 3, 4, 5, 6, 7

Acetylcholine (muscarinic M2, Growth hormone

M4; inhibition)
Prolactin

Dopamine 1,2 Placental lactogen

Serotonin Erythropoietin

Melatonin (inhibition?) Nerve growth factor

Glucagon Serine kinase

G protein-coupled receptors Catalytic receptors* Channel-linked
receptors*

Somatostatin (inhibition) Activin

Growth hormone-releasing Inhibin

hormone

Vasoactive intestinal peptide Transforming growth

factor-β

Endogenous opiate peptides

(inhibition)

Gastrin-releasing peptide (GRP)

Galanin (inhibition)

Secretin

Calcitonin

Parathyroid hormone (PTH)

Vasopressin

Melanocyte-stimulating hormone

Angiotensin II
(inhibition/stimulation)

Prostaglandins (PGE1, PGE2)

A2 Adenosine

Guanylate Cyclase

Atrial natriuretic peptide

Brain natriuretic peptide

G protein-coupled receptors Catalytic receptors* Channel-linked
receptors*

Phospholipase C/phosphoinositol turnover and calcium flux

LH/hCG

TSH

Luteinizing hormone-releasing
hormone (LHRH)

Thyrotropin-releasing hormone
(TRH)

Corticotropin-releasing hormone

Cholecystokinin B/gastrin

Dopamine 1,2

Serotonin

Acetylcholine (muscarinic M1,

M3, M5)

α-Adrenergic catecholamines
(stimulation)

Angiotensin II

Thrombin

Bombesin/GRP

Calcitonin

PTH

Vasopressin
G protein-coupled receptors Catalytic receptors* Channel-linked
receptors*

Oxytocin

Interleukin (IL)-1 and 8

Prostaglandin F2α

Thromboxane A2/prostaglandin H2

Leukotrienes