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rapidly fading. The important issue is to There is no ‘best’ time to transfer between as important are the relationships that you
understand that academia and industry have academia and industry; however, the more establish early in your training: they provide
different objectives. Although this can result established you are and the stronger your emotional support, scientific insights and
in enormously productive collaborations CV, the more you can call the shots in both career information. I want to stress the
between the two, in the end industry is about academia and industry. value of having a supportive social network
producing an end product whereas academia during training. Graduate school is usually
is simply interested in moving knowledge What is the best way for a emotionally difficult, although no one tells
forward. Which path you should choose is neuroscientist early in their career to students this before they enter their first
therefore a matter of introspection. Are you establish contacts with other neuroscientists? year. I tell students that the most important
interested in knowledge for its own sake or task in pre-doctoral neuroscience training is
do you wish to see that knowledge applied? T.B. I have used computers since 1963, when learning to deal with failure. Compared with
As for moving from one to another, I I started writing programs for a living, and I earlier phases of your training, in graduate
believe that scientists should be cautious. have used the internet ever since it was avail- school there is less structure, the measures of
Although a successful young scientist able. Yet, I am skeptical of the real value of success can be unclear, and sometimes it can
will find many exciting opportunities in an internet-based scientific network between seem that nothing ever works the way you
industry, it tends to be difficult to return to people who have not had a face-to-face want it to. For students who have so far only
academia from industry. Obviously there meeting. The best way for a neuroscientist known success, this can be really discourag-
are exceptions: for example, Lee Rubin at the who is early in their career to become part ing. Having a support group that includes
Harvard Stem Cell Institute has successfully of a network is through participation in as some students who have survived the tough
gone back and forth between academia and many small meetings (100–300 people) times can be really helpful.
industry throughout his career, but I believe as possible: to get to know personally the key
that his inclinations and talents make him opinion leaders and the promising young N.R. Networking is critical. It really helps
uniquely suited to be the interface between people in the field. Once such meetings have if you are a naturally outgoing person, but
the two. taken place, the internet is a fine tool to keep many of us are not, and there is a danger
the contacts made at these meetings alive. In of being too pushy (here there can be real
T.I. The National Institute of Mental Health addition, seeing such key people in action cultural differences). Of course, attend all
(NIMH) supports training in academia but helps you to understand their statements and the meetings you can, talk to people and
not in industry. The cultures are different put them in context and follow their discus- participate in the external events — the bar
but not antagonistic. sions on the internet. I believe that, com- is an incredibly important place for network-
pared with actual scientific achievements, ing! Spend time innovating and invigorating:
N.R. The relationship is getting better, networking skills are far overrated among for example, organize a seminar series or a
but there is much room for improvement young scientists: in the long run, no amount meeting of your colleagues, volunteer as the
as there is still some serious mutual distrust. of networking skills will replace the impact of student representative for your national soci-
As an academic who has worked and still the original findings you have made. ety, offer to help organize a local or national
works very closely with industry myself, I I should also add that your mentor’s meeting or host a visiting speaker (and make
am horrified by the widespread, very nega- networks are much more important than we sure that they are really well looked-after).
tive views of industry held by some people admit: coming from the laboratory of X might Write to colleagues politely and with some
in academia. To some it is as though, in just be the best networking tool that there is. inspiration: for example, an e‑mail in which
transferring to industry, perfectly normal you just ask ‘Would you like to collaborate?’
and acceptable scientists move to ‘the dark G.F. At present, small meetings provide by is likely to get an instant ‘delete’ from a busy
side’ and become something unacceptable. far the best way to get to know people both senior colleague. A better approach would
In fact, most scientists who work in industry in and outside your field. My uncontested be to compliment them on their work and
are just the same as those in academia, as is favorites are Gordon conferences and I never try to hook them on what you are interested
their key goal — namely, to solve problems. fail to come back from them invigorated. in. If you receive no reply, try one very polite
There are no easy answers about transi- Large meetings, such as the annual one follow-up.
tions between academia and industry sponsored by the Society for Neuroscience Scientific blogs might help communica-
because the problems and issues involved in (SFN), offer huge variety, but this comes at tion between scientists, as long as they do
moving between the two are case-specific. A the cost of intimacy. For the new graduate not descend into chit-chat and unvalidated
transfer from academia to a small biotech- student or postdoctoral researcher enter- comments.
nology company where you will still publish ing neuroscience, the SFN meeting can be
peer-reviewed papers would allow an easy overwhelming. Obviously the internet offers Apart from training young scientists in
transition back to academia. By contrast, a growing new interface, but I question research techniques, do current Ph.D.
transferring into an area where it is hard to whether it will ever take the place of face-to- and postdoctoral training programmes
maintain the traditional ‘academic’ aspects face interactions. In this regard, the greatest prepare neuroscientists adequately for careers
of a curriculum vitae (CV) (such as being impact is likely to come from open-source at and away from the bench?
published, successfully applying for grants, publishing and novel initiatives such as the
supervising and mentoring Ph.D. students, Faculty of 1000. T.B. Current postdoctoral training is fully
teaching, et cetera) makes it much harder sufficient, in particular if the postdoctoral
to move back. However, once you have T.I. Neuroscience, like any modern science, researchers have been in at least two labo-
reached a really senior level none of this is a surprisingly social endeavour. We all rec- ratories of different expertise, preferably in
matters so much. ognize the importance of ‘team science’. Just different countries. Today’s postdoctoral
researchers are far savvier than we were (I training provides both. Content changes its theories than ever before. Although speed
got my biology Ph.D. in 1973). You should quickly in neuroscience: last year’s facts can and specialization are now highly valued,
realize that a good outcome in a job inter- become next year’s myths. Although learning it becomes clear how much weaker we are
view requires you to show the laboratory the content — for example, neuroanatomy integratively compared with molecularly
head that you either bring a very specific or molecular biology — is essential, it should when a drug for a neurological or psychiatric
skill and methodology to the laboratory or always be considered the current state of disease is sought.
that you have the general ability to learn knowledge. By contrast, the process of doing The development of the internet, allow-
whatever it takes to be successful in the science is remarkably stable — by process I ing easy access to articles that have been
position. If the group leader does not want mean learning how to pose questions, design published after 1980, has been great, but
you for the specific skill and does not think experiments and deal with unexpected in many respects the internet’s influence is
that you are a ‘generalist’, then you will not results. These skills are valuable in a range of overrated: when I ask colleagues how many
get the position. Doing a Master of Business careers, from academia to industry, business important papers they have read in the past
Administration (MBA) degree or other non- or law. year, they still answer 3–5, although many
scientific degree often backfires because it How to prepare for a career in science? I more articles are published yearly now than
begs the question, did you not trust that you believe that the best predictor of success as 20 years ago. The number of truly original
will be a good enough scientist? Doing such an academic scientist is a trainee’s ability to papers has not increased, and the extent
degrees and knowing about topics unrelated write clearly. It is no accident that many of to which they are read is limited by the
to research has become possible and might our most successful scientists were English internet. It is sad that most young, internet-
be desirable for both researchers in industry majors. Of course, grant writing is not like weaned neuroscientists have never read the
and academic scientists, but it is deep writing fiction, but it is a learned skill that classic papers by Ramón y Cajal, John C.
knowledge of your specialty and not having should be mastered during a postdoctoral Eccles, Bernard Katz, et cetera.
another degree that will lend you credibility. fellowship, if not before. In addition, suc- My research career has not been differ-
cessful scientists need to be business manag- ent from what I envisioned because, quite
G.F. Anyone who has done bench science ers, life coaches and team players — all skills frankly, I did not have today’s students’
knows the high level of dedication and perse- that can be honed during training. career goals. I had no blueprint that I could
verance required. That sort of life experience now compare with my actual career. I was
will serve you well regardless of what you end N.R. Some training programmes do provide given some advice by a famous particle
up doing. Neither a Ph.D. nor a postdoctoral adequate training. At my university, Ph.D. physicist for whom I worked as a 17-year-
programme can or should try to prepare students and young postdoctoral research- old: “Go and train with the best, they will not
individuals for all possible eventualities. ers receive training in career development, only teach you but they will hand you over
Obviously, the one career you would hope verbal and written communication, how to the next great scientist as a piece of their
they would prepare you for is the one that to seek external funding, how to handle handiwork until such time that you want to
involves directing an independent laboratory, collaborations, conflicts and supervision stand on your own”. This is exactly what hap-
but even here they are likely to fall short. and much more. These training courses are pened to me. I therefore believe that finding
Successful PIs inevitably end up wearing essential and in fact do not take you away the right laboratory and fighting to get into it
many different hats. They need to be able to from the laboratory for that long. If you are is worth everything. Because the people who
come up with projects, write grants and deal not receiving this sort of support, demand it run these laboratories are all great for some
with the strong personalities of the people or move! particular reason, and it is worth the fight to
working in their laboratories (as might be learn from them.
expected, people with strong personalities What are the major developments in My research career was somewhat lonely
are precisely the kind of creative people you (neuro)science that have affected your because I chose a very specialized subject
find in good laboratories). It is the rare PI career? that was often regarded as a narrow topic,
who continues to do bench science from namely the fever response. In this field there
start to finish within a few years of running T.B. There have been many major develop- were no great, well-funded laboratories, so
their own laboratory. As Andrew Lumsden ments during the time that I have worked in instead I went to study with great scientists
once put it, “We work very hard to find a neuroscience (starting in 1973). These include in many different fields, in the laboratories
few good chaps who can do an experiment the development of patch-clamp techniques, of Ulf von Euler and Lennart Stjärne, Paul
decently and then make damn sure they transgenic animals, gene cloning and expres- Greengard, Gerald Edelman, Marshall
never do another one.” In the end, the quality sion, high specific-activity labelled ligands, Nirenberg, Julius Axelrod and Bruce
that unifies the most successful scientists is imaging techniques, methods for measuring Merrifield for longer or shorter times, and
their ability to identify important problems single-neuron transcriptomes and many I learned from each of them, and from my
and devise approaches to address them. Both others. It is possible to ask questions about colleagues in industry, immensely.
students and postdoctoral researchers tend behaviour at a molecular level today, whereas My goals of working in science, teaching
to become absorbed in the details of their this was not in the books in the 1970s. and staying clean in science could have been
projects. The extent to which they can learn The number of neuroscientists has grown fulfilled in academia and industry alike. My
to see the broader picture during their train- around 20-fold in this time — this includes advice for any young neuroscientist is to find
ing is, I believe, the best predictor of their scientists who produce poor data as well as a good mentor in a good institution where
future success. those who contribute good data. It has also many other disciplines flourish too, as a
become clear that the discipline, although it lot of the answers you seek will come from
T.I. It is important to separate learning about is developing at fantastic rates in its subdis- physicists, chemists and others outside of
content from learning about process. Good ciplines, is further removed from integrating neuroscience.
G.F. I have had the great fortune to be (PCR), transgenic mice and, recently, in terms of our ability to answer important
working in mammalian developmental channelrhodopsin rapidly changed the questions, there has never been a better time
neurobiology during the period when conversation in systems neuroscience. The to go into neuroscience. What I would give to
technical advancements have finally made ability to access the scientific literature start over now that we can finally answer the
the problems tractable. Near the end of through the internet has transformed the questions I could barely ask 30 years ago!
my Ph.D., I was rather depressed by the information base of what all of us do. The
realization that the state of neurobiology at most important lesson from all of this is that N.R. There have been massive changes in
that time allowed us to identify important we should be training students for change. technology, approaches and discovery. I can
questions concerning the development of the Most of what I was taught about the brain remember going through numerous pages
mammalian nervous system but prevented and behaviour 30 years ago would now be of Current Contents each week (a weekly
us from designing experiments with the considered obsolete. Much of what we are print publication that documented all of the
sophistication to address them rigorously. teaching today might look no better 30 years published papers in biology and medicine)
The advent of molecular biology, cloning from now. At NIMH we are always looking and marking them off before going to the
and gene targeting transformed the field. for the scientist who will be a ‘disruptive library to request a photocopy! I made slides
The first step in overcoming the impasse innovator’ and overthrow today’s dogma. with Letraset (sheets of artwork elements
was developing the ability to clone genes and My own career has been completely that could be transferred to create figures)
study their expression in situ. Even more nonlinear and unplanned. I trained in on tracing paper, and faxes were the only fast
important was the arrival of gene target- psychiatry, learned neuroscience at the method of communication. My god I sound
ing. The development of conditional gene bench and picked up administrative skills old! Scientific breakthroughs have also come
targeting then allowed the creation of tools on the fly. Throughout, I have been obsessed thick and fast — for example, brain imag-
for not only studying gene function but, with the neural basis of emotion, especially ing methods, computational and systems
more importantly, for functionally altering social emotion such as parental love. When approaches, and the multiple ways we now
activity in the nervous system in a directed I started in neuroscience, neuropeptides have fast access to worldwide technologies
fashion. The opportunities to study both were the hot topic and receptors were just have all promoted rapid scientific develop-
the development and the function of the being mapped. These opportunities took me ment; but, on the down side, there has also
nervous system are now open-ended. This into the neuroanatomy of systems that are been a massive increase in the regulatory
stems to a large extent from the pioneering important for behaviour. With the advent of environment and in bureaucracy.
work of the Nobel Prize winners Mario transgenic mice and more precise molecular doi:10.1038/nrn2386
Capecchi, Martin Evans and Oliver Smithies. tools, I had to learn about molecular biology. 1. Dyson, F. J. Imagined Worlds. (Harvard Univ. Press,
Indeed, from the perspective of mammalian In the past decade, I have become more Cambridge, Massachusetts, 1997).
neurobiology, the progress that will be made interested in the public health implications Further information
in the next 10 years will largely be made by of neuroscience. How can we translate our Tamas Bartfai’s homepage:
standing on their shoulders. understanding of the brain and behaviour http://dorriscenter.scripps.edu/bartfai.html
Gord Fishell’s homepage
into better outcomes for people with mental http://saturn.med.nyu.edu/research/dg/fishelllab/
T.I. Freeman Dyson famously noted more disorders? Now, with the emerging power of National Institute of Mental Health:
http://www.nimh.nih.gov/
than 10 years ago that “New directions in clinical genomics, we can undertake reverse Nancy Rothwell’s homepage:
science are launched by new tools much translation and take clinical discoveries back http://www.ls.manchester.ac.uk/people/profile/?id=398
NIH Blueprint for Neuroscience Research:
more often than by new concepts.”1. I basi- to the laboratory to understand how genomic http://neuroscienceblueprint.nih.gov/neuroscience_
cally agree with that observation: the devel- variation alters neural systems and neural resources/training.htm
Faculty of 1000: http://www.facultyof1000.com/
opment of the polymerase chain reaction function. One thing is entirely clear to me: