IMMUNOFLUORESCENCE FINDINGS IN RPGN

Immunofluorescence Antibodies Disease Symptoms anca Biopsy/

pattern granuloma
LINEAR Anti- GOODPASTURE (antibody
basement SYNDROME against collagen
membrane in BM of:
antibody Lungs >>
hemoptysis
Kidney >>
hemoptysis
GRANULAR Immune- PSGN (most common)
complex or
deposition DIFFUSE
>>> lumpy PROLIFERATIVE
bumpy GLOMERULONEPHRITIS
granular
pattern
NEGATIVE Pauci- Wegener NASOPHARYNX c-anca With
immune granulomatosis >> sinusitis, (cytoplasmic necrotizing
nasopharyngeal antineutrophil granulomas
ulceration antibodies >> with adjacent
LUNGS >>> see Pathoma necrotizing
hemoptysis vasculitis) vasculitis
KIDNEY >>>
hematuria
Microscopic LUNGS >>> p-anca NO
polyangiitis hemoptysis (perinuclear granulomas
KIDNEY >>> antineutrophil
hematuria antibodies)
Churg-Strauss LUNGS >> With
syndrome asthma granuloma and
HEART microscopic
peripheral
eosinophilia