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Approval
Approval Group Job Title, Chair of Committee Date
Maternity & Children’s Services Chair, Maternity Clinical 9th January
Clinical Governance Committee Governance Committee 2015
Change History
Version Date Author, job title Reason
1.0 November Dr S Hirsi-Farah (Locum Amalgamation of existing
2014 Obstetric Consultant), Julie separate guidelines on this
Comer (Clinical Lead Midwife condition and incorporating
NICE (2010) guidance
Change History
Version Date Author, job title Reason
1.0 08/11/13 Angela Tyler (RM) Guidance for best practice
Guideline for the management of Hypertensive disease and pre-eclampsia in the Antenatal period
(GL853)
Approval
Approval Group Job Title, Chair of Committee Date
Maternity & Children’s Services Clinical Chair, Maternity Clinical Governance
Governance Committee Committee
Change History
Version Date Author, job title Reason
6.0 March 2014 Jane Siddall (Consultant in Reviewed
Fetomaternal medicine)
Change History
Version Date Author, job title Reason
7.0 March 2014 Mark Selinger & Jane Siddall, Reviewed
(Consultants in Feto maternal
Medicine),
Hypertension & mild to moderate PET – Postpartum medication and discharge planning guideline
(GL855)
Approval
Approval Group Job Title, Chair of Committee Date
Maternity & Children’s Services Clinical Chair, Maternity Clinical Governance 5th January 2012
Governance Committee Committee
Change History
Version Date Author, job title Reason
6.0 March 2014 Mark Selinger & Jane Siddall Review due and changes on pg 3
(Consultants in Fetomaternal added by GV
medicine), Gill Valentine (Dir. of
Midwifery)
Change History
Version Date Author, job title Reason
13.0 Feb 2013 P Street (Consultant Obstrician) Reviewed
Contents
1.0 Overview ........................................................................................................................... 5
2.0 Acute Management of Hypertension ................................................................................. 9
3.0 First presentation and outpatient antenatal care ............................................................. 11
4.0 Management of antenatal inpatients with hypertension .................................................. 15
4.1 Antenatal inpatient Care Pathway: Severe Chronic Hypertension .................................. 15
4.2 Antenatal in-patient care pathway: Gestational Hypertension......................................... 17
4.3 Antenatal Inpatient care pathway: Pre-eclampsia ........................................................... 20
5.0 Intrapartum care .............................................................................................................. 25
5.1 Mild or moderate hypertension (BP 140/90-159/109 mmHg).......................................... 25
5.2 Immediate postnatal care on the labour ward ................................................................. 25
6.0 Management of Severe Hypertension and Severe Pre eclampsia / eclampsia on ............
labour ward...................................................................................................................... 29
6.1 Immediate management of an eclamptic fit and magnesium sulphate infusion. ............. 31
6.2 Labour Ward care pathway: Severe Hypertension, severe pre-eclampsia and ................
Eclampsia........................................................................................................................ 36
6.3 Immediate postnatal care of women who have received MgSO4 ................................... 37
6.4 Immediate postnatal care on the labour ward of women with severe hypertension ...........
and/or eclampsia. ............................................................................................................ 37
6.5 Postnatal care pathway on labour ward: ......................................................................... 38
7.0 In-patient postnatal care.................................................................................................. 39
7.1 Post natal ward management of hypertensive women.................................................... 39
7.2 Post natal blood pressure management:......................................................................... 39
7.3 Maintenance of blood pressure: ...................................................................................... 39
8.0 Postnatal care following discharge from hospital ............................................................ 41
8.1 Women with Chronic Hypertension ................................................................................. 41
8.2 Women with Gestational Hypertension ........................................................................... 42
8.3 Women with Pre-Eclampsia ............................................................................................ 42
9.0 References ...................................................................................................................... 43
10.0 Monitoring Appendices and tables .................................................................................. 43
Appendix 1: Indication for early delivery in a woman with pre-eclampsia who require ...............
in-patient management........................................................................................ 44
Appendix 2a: Community midwife discharge Letter .............................................................. 45
Appendix 2b: Community midwife discharge Letter .............................................................. 46
Appendix 2c: Community midwife discharge Letter .............................................................. 48
Appendix 3: Discharge letter to GP ......................................................................................... 50
Author: Dr S Hirsi-Farah, Julie Comer Date: January 2015
Job Title: Consultant Obstetrician (Locum), Clinical Lead Review Date: January 2017
midwife
Policy Lead: Group Director Urgent Care Version: 1.0 ratified 9th Jan
Mat CG mtg
Location: Maternity CG Shared drive/ Intrapartum/ GL861
This document is valid only on date Last printed 02/06/2015 12:11:00 Page 3 of 63
Maternity Guidelines – Hypertesion (GL952) January 2015
1.0 Overview
Hypertensive disorders during pregnancy occur in women with pre-existing chronic
hypertension and in women who develop new-onset hypertension in the second half of
pregnancy.
Hypertensive disease in pregnancy remains a leading cause of direct maternal death, at
a rate of 7.0 per million maternities (RCOG 2004 AND CMACE 2011). In the last
confidential enquiry, the most common aetiology of hypertensive deaths was intracranial
haemorrhage, secondary to uncontrolled blood pressure, usually systolic.
Hypertension in pregnancy carry risks for mothers and also carries risks for babies in
terms of higher rates of perinatal mortality, preterm birth and low birth weight.
This guideline contains recommendations for the assessment, diagnosis and management
of hypertension in pregnancy in the antenatal, intrapartum and postnatal periods in line
with NICE clinical guideline 107(2010).
Definitions:-
• Chronic hypertension is hypertension that is present at the booking visit or before
20 weeks or if the woman is already taking antihypertensive medication when
referred to maternity services. It can be primary or secondary in aetiology.
• Gestational hypertension is new hypertension presenting after 20 weeks without
significant proteinuria.
• Pre-eclampsia is new hypertension presenting after 20 weeks with significant
proteinuria.
Significant proteinuria is if the urinary protein: creatinine ratio (PCR) is greater than
30mg/mmol or a validated 24-hour urine collection result shows greater than 300 mg
protein per save.
Urinalysis:-
Dipstick urinalysis currently is non automated. Any dipstick analysis in the hospital must be
tested using an automated reagent-strip reading device.
If the urine analysis result is 1+ or more of protein, send a urine specimen for urinary PCR
to quantify proteinuria.
Proteinuria is significant if the PCR is greater than 30 mg/mmol. Proteinuira, once present,
is a marker for PET.
Blood tests:-
If you request a PET screen from the laboratory (1purple top and 1gold top bottle)
They will test for– FBC, U&E’s, LFT’s - ALT, bilirubin, Albumin and check for clotting only if
platelets count < 100,000
NICE specifically recommends that uric acid analysis is not required as part of the PET
screen.
Ultrasound scan:-
NICE recommends that if a growth scan is required in a hypertensive woman the only
measurements required are;
• fetal growth
• amniotic fluid volume measurement (deepest pool in mm)
• Umbilical artery flow waveform assessment (EDF present/absent)
Diagnosis:-
When a woman attends the hospital with hypertension and/or proteinuria the registrar or
consultant must indicate whether she is to follow the management pathway for:
• Chronic hypertension
• Gestational hypertension
• Pre-eclampsia
The agreed management pathway to be followed must be clearly documented in the
notes. If the woman is an inpatient the pathway should be recorded on the hand over
board/ sheet (LW and/or Iffley).
If the woman is admitted, or is managed as an outpatient with moderate/severe, chronic
or gestational hypertension then she must have a named consultant. If the woman has
previously had consultant care in this pregnancy her named consultant should be recorded
on the front page of her hand held and hospital notes. Woman under GP/MW care should
be changed to the on call consultant for that day.
The registrar/midwife should ensure that the correct management pathway is being
followed. If the midwife feels that the registrar is not following the correct pathway she
must discuss this with the registrar and/or responsible consultant.
If the pathway for management remains unclear it is important that the registrar/midwife
contact an Obstetric consultant for a decision.
If a Consultant decides that the usual management pathway is not appropriate then follow
the Consultant’s plan which must be clearly documented and reasons for deviation from
RBFT guidelines must be stated. Ongoing management decisions in these cases must be
made by the Consultant.
In-patient management for hypertension is not recommended (NICE 2010) for women with
chronic or gestational hypertension unless the blood pressure is >160/110mmHg (severe
hypertension as defined by NICE 2010). Drug treatment is however recommended if the
BP is >150/100mmHg.
Women on antihypertensive medication must not be exclusively managed in Day
Assessment Unit (DAU); the woman must be given a clinic appointment at least every 2-3
weeks.
Treatment of Hypertension:-
If anti-hypertensive treatment is started the woman must be given a “Raised Blood
Pressure in Pregnancy” or PET patient information leaflet. This must be documented in
her hand held notes.
In pregnancy aim to keep the BP lower than 150/100mmHg (140/90mmHg in women with
target organ damage e.g. renal disease. This lower cut off must be advised by a
consultant).
In postnatal women with chronic hypertension aim to keep blood pressure lower than
140/90mmHg.
In postnatal women with gestational hypertension or pre eclampsia aim to keep blood
pressure lower than 150/100mmHg.
Before prescribing any medication check and record in the notes any current medication,
history of asthma, diabetes and drug reactions.
Labetalol is the first line anti-hypertensive advised by NICE (2010) for pregnancy, provided
the woman is not asthmatic, use with caution in diabetics. It should be started at a low
dose (100mg BD) and increased as needed.
If a woman can not have Labetalol, or needs a second line drug NICE (2010) recommends
Methyldopa or Nifedipine. Methyldopa should start with a loading dose of 500mg, then
250mg TDS then increased as needed. Modified release Nifedipine should start at 10mg
BD and be increased as needed.
If a woman has a BP >150/100 mmHg recorded (using the correct size BP cuff):
1. The midwife should record the BP on the MOWS chart and ask the women about
symptoms.
2. The midwife should repeat and record the BP 15 minutes later, if the BP remains
>150/100 mmHg the SHO must review the woman within 1 hour. If the BP ≤150/100
mmHg - the midwife does not need to repeat the BP until it is next due on the
woman’s management regime.
3. CTG is only required if the woman reports abnormal symptoms or the BP is
>160/110 on re-check
4. When the SHO reviews the woman he/she should take note of symptoms, drug
allergies and history of asthma. He/she should also note which management
pathway the woman is currently following, but must remember that women with
chronic or gestational hypertension can develop pre-eclampsia.
5. The SHO should briefly examine the woman checking for uterine or hepatic
tenderness, hypereflexia and clonus. If the woman has abnormal symptoms or
signs her management must be promptly discussed with a registrar.
6. A PET screen is only required if the women has abnormal symptoms or signs, or it is
>3 days since the last blood test. Results must be documented on the flow chart.
7. If the woman is not currently taking any antihypertensive medication:
• Repeat BP 1 hour (and if needed 2 hours) after the 2nd dose of medication. If
the BP is still >150/100 mmHg 2 hours after the 2nd dose of medication the
woman’s management MUST be discussed with a consultant. Parenteral
antihypertensive medication should be considered (management pathway and
regimes are given in the severe hypertension, severe pre-eclampsia on labour
ward section of this guideline).
9. The SHO must discuss his/her management with a registrar or consultant, and must
document this discussion in the woman’s notes.
10. Whilst the women is an inpatient her MOWS chart should be kept on the clip board
at the end of her bed, with her drug chart and the laminate indicating which BP
regime she is following. This is important so that the documents are reviewed on the
medical rounds.
Referral Sign/Symptom:-
NO NO
This flowchart is
Hypertension? Proteinuria? not appropriate
YE
acc
NO
NO NO
Was there YES
hypertension at
YES
If the midwife/registrar could not agree on the most suitable management care
pathway they must discussed this with a consultant.
At each presentation the woman must be assessed using the above flow chart to ensure
that the correct management care pathway is followed. Remember women with chronic
hypertension or gestational hypertension can develop pre-eclampsia (if that is the case
change the management care pathway to PET).
Management must follow the documented pathway unless a consultant decides that the
usual management pathway is not appropriate (see overview below).
Most women with chronic hypertension will already be under the If BP ≥150/100mmHg a
Blood care of a consultant and have a management care pathway in registrar / Consultant
pressure place. review is required and a
measurement Aim for BP <150/100mmHg unless the woman with target- organ change in medication
damage(e.g kidney disease) when BP should be <140/90mmHg needs to be considered
Continue antenatal antihypertensive treatment through out the pregnancy and review long-
term antihypertensive treatment 2 weeks after the birth.
Treatment Offer women with chronic hypertension a medical review at the postnatal review (6–8 weeks
after the birth) with pre-pregnancy counselling
Admit to hospital, At
After 32 weeks:
least four times a day If seen in DAU on 3
Blood Weekly
occasions, referral to
pressure Twice weekly
Consultant ANC for
Once controlled and
measurement Prior to 32 weeks:
discharged check further assessment
Twice weekly
twice weekly
Before 34 weeks
• Manage conservatively
• Consultant obstetric staff to :
1. Document maternal (biomedical, haematological and
If the woman is <36
clinical) and fetal indications for elective birth before 34
weeks gestation
weeks
give a course of
2. Write a plan for antenatal fetal monitoring (CTG and
corticosteroids for
scan)
fetal lung
• Offer birth if severe refractory hypertension or maternal or fetal
maturation (see
clinical indication develops as defined in plan.
Timing of preterm labour
34-36+6 weeks
birth guidelines).
• Recommend birth after 34 weeks if pre-eclampsia with severe
hypertension and BP is controlled
All decisions
• Offer birth at 34- 36+6 weeks to pre-eclampsia with mild and regarding delivery
moderate hypertension only when there is a concern about the should be made
maternal and/ or the fetal condition. after discussions
After 37 weeks with neonatal team
• The exact timing of delivery of mild/ and stable moderate pre-
eclampsia should be decided between the woman and the
consultant obstetrician, discussion of maternal and fetal
indications for birth should be documented in case notes.
Author: Dr S Hirsi-Farah, Julie Comer Date: January 2015
Job Title: Consultant Obstetrician (Locum), Clinical Lead Review Date: January 2017
midwife
Policy Lead: Group Director Urgent Care Version: 1.0 ratified 9th Jan
Mat CG mtg
Location: Maternity CG Shared drive/ Intrapartum/ GL861
This document is valid only on date Last printed 02/06/2015 12:11:00 Page 14 of 63
Maternity Guidelines – Hypertesion (GL952) January 2015
Fetal
Monitoring CTG – on day of admission. If the CTG is not normal it must be
Do not repeat if a normal CTG has already promptly reviewed by an obstetric
been recorded that day. Repeat CTG weekly registrar who will discuss with an
unless the woman reports: obstetric consultant
Author: • Change
Dr S Hirsi-Farah, in fetal
Julie Comermovements Date: January 2015
Job Title: • Vaginal
Consultant bleeding
Obstetrician (Locum), Clinical Lead Review Date: January 2017
• Abdominal pain
midwife
Policy Lead: Group
• Director Urgent in
Deterioration Care
maternal condition Version: 1.0 ratified 9th Jan
Mat CG mtg
Location: Maternity CG Shared drive/ Intrapartum/ GL861
This document is valid only on date Last printed 02/06/2015 12:11:00 Page 18 of 63
Maternity Guidelines – Hypertesion (GL952) January 2015
5. Timing of Delivery:
a. Aim to manage women with pre-eclampsia conservatively until 34+0 weeks
b. IOL or planned caesarean (as clinically appropriate) could be considered for
women with pre-eclampsia after 37+0 weeks. This must be agreed with a
consultant; this should be documented in the woman’s notes.
3. If methyldopa was not used during the antenatal period, continue antenatal
antihypertensive treatment.
4. Aim to maintain BP <150/100mmHg.
5. Transfer to Iffley ward when clinically stable and suitable for transfer.
6. A clear plan of care must be documented in the postnatal notes.
Urine • this indicates that she has developed pre- Woman to be examined by the
eclampsia, and must now be managed on the PET registrar if develops significant
care pathway. proteinuria.
• Follow bladder care guidelines
Fetal Monitoring • Continuous CTG established labour. Follow fetal monitoring guideline (GL
Definitions
• Eclampsia: one or more epileptiform fits in a pregnant, or recently delivered
woman, in association with clinical or biochemical pre-eclampsia
• Severe (fulminating) pre-eclampsia: DBP > 110 mm Hg, SBP> 160 mm
Hg and proteinurea > 2+ on 2 occasions
Or
• Signs and/or symptoms of imminent eclampsia ie. persistent frontal headache,
visual disturbances, epigastric tenderness, hyper-reflexia and evidence of any
renal, hepatic or haematological impairment.
A red Eclampsia box containing all the necessary drugs and equipment is stored in
the bottom drawer of the Emergency trolleys on the Delivery Suite, Marsh and Iffley
Wards and theatre.
Anti-hypertensive therapy:
Continue use of antenatal antihypertensive treatment during labour.
If blood pressure becomes unstable consider treatment with one of the following parenteral
antihypertensive treatments and stop the oral antihypertensive treatments.
Hydralazine
• Slow intravenous bolus of 5-20 mg (20mg hydralazine in 20 ml 0.9% NaCl) as
slow bolus over 10 – 20 minutes for immediate control.
• Hydralazine maintenance infusion- Hydralazine 60 mg in 60 ml 0.9% NaCl
(1mg/ml) administered by pump at 1-12 ml/hr (1-12 mg/hr) titrated against
diastolic blood pressure. (The side effects of Hydralazine are tachycardia,
headache, vomiting and tremor)
Labetalol
• 200mg per oral stat (prior to or in absence of iv access) or IV 50mg bolus
slowly over 5 minutes, increase bolus by 40-80 mg every 10 minutes to max
of 200mg.
• Labetalol maintenance: 100mg Labetalol in 100 ml 0.9% NaCl and
administer at a rate of 20ml/hour, doubling every 30 minutes to a max of
160ml/hr until BP control is achieved . Consider double strength solution (200
mg in 100 ml) if BP not controlled.
• NB: Labetalol is contraindicated in asthma, bradycardia and
pulmonary oedema. Use with caution in diabetics.
• Nifedipine: 10 mg orally, repeated once, after 30 min if BP not adequately
controlled (≥160/110 mmHg) commence either IV labetalol or IV hydralazine -
starting with bolus dose first.
If these measures fail to control the BP and other pharmacological agents have to
be administered, the patient should be transferred to ICU following delivery.
Take and record blood pressure (BP) every 5 minutes using an automated BP machine
to monitor response to treatment and to ensure BP stabilising,then check BP at 15 min
intervals using automatic BP machine and manually once every hour using appropriate
sized BP.
Once the BP has been ≤150/100mmHg for 60 minutes return to measuring and recording
BP hourly. Remember to document all the readings on HDU chart.
1. Keep nil by mouth, give Ranitidine and cyclizine as per guideline. Commence iv
fluids unless delivery in next 12hrs is not considered.
2. Take blood for PET screen and a Group and Save on admission to labour ward.
Take a PET screen every 6-12 hours, a clotting screen is required only if there is
concern about platelet count. Ensure all results are recorded on HDU chart clearly
documenting time bloods taken.
3. If PET diagnosis was not confirmed prior to this admission test urine for protienuria
,if urine dipstick on admission is 1+ or greater this confirms the diagnosis and
urgent urinary PCR is needed unless delivery is imminent. If the woman is known
to have a urinary PCR >30 mg/ml do not repeat the urine dipstick.
4. Continuous electronic fetal monitoring must be commenced. Follow fetal monitoring
guideline.
5. Record fluid balance carefully, all IV fluids should be administered via a pump
• If a catheter is in situ record urine output hourly, if not catheterised measure
and record each void.
• Limit maintenance fluids 120ml/hr in labour, 80mls/hour if antenatal or
postnatal. Reduce or stop iv fluids if drinking.
Anticonvulsants
Consider the use of MgSO4 if a woman has severe PET (see below) the registrar should
discuss this decision with the on call consultant. The outcome of the discussion must be
documented in the woman’s notes using a SBAR sticker. The labour ward shift leader
must be informed.
Severe hypertension (BP ≥160/110 mmHg) or mild or moderate hypertension and
proteinuria with at least one of the following;
• Severe headache
• Visual disturbances
• Severe pain below ribs or vomiting
• Papilloedema
• Clonus (>3beats)
• Liver tenderness
• HELLP syndrome
• Platelet count <100X10 q/l
• ALT or AST >70iu/l
3. Ring 2222 and ask for ‘Obstetric emergency’, call LW coordinator to room if not
already present.
4. Establish iv line (take 20 ml blood).
• Loading dose of 4g [ 8 ml 50% MgSO4 (1 ampoule contains 10ml of
MgSO4 which is equal 5g) in 32 ml normal saline over 20 minutes]
• Followed by maintenance infusion of 1g/hour for 24hours
• 10ml 50% MgSO4 (5g) - made up to 50ml with 40ml normal saline given
by syringe pump at 10ml/hr (1g per hour).
• Further dose of 2-4g (4-8 ml 50% MgSO4) given over 5 minutes if
recurrent seizures while on the maintenance infusion (2g if maternal
weight < 70Kg).
Monitoring during MgSO4 therapy
Every 15 minutes during first two hours of therapy and hourly thereafter if
condition stable, until stopped on consultant obstetrician review
• Continuous ECG and pulse oximetry monitoring throughout O2 saturation
and pulse
• Blood pressure
• Patellar reflexes (or biceps if there is a functioning epidural)
• Respiratory rate
• Conscious level
• Hourly urine output
Magnesium Sulphate Toxicity – if any of signs below are present, stop MgSO4
infusion and request immediate medical review
• Urine output <100ml in 4 hours. If there are no other signs of toxicity
consider reducing the Magnesium infusion to 0.5g/hr.
• Absent patellar reflex - if respiration normal (more than 10 breaths per
minute) stop Magnesium Sulphate infusion until the reflexes return
• Respiratory depression (less than 10 breaths per minute) give O2 by
facemask, stop Magnesium Sulphate infusion, give 10mls, 10% calcium
gluconate given by slow intravenous injection over 5-10 minutes. Maintain
airway and nurse in the recovery position.
•
Respiratory arrest - intubate and ventilate, stop Magnesium sulphate
therapy. Give 10mls 10% calcium gluconate IV over 5-10 minutes.
Continue ventilation until spontaneous breathing recurs
Send blood for:
• PET screen
• Clotting screen
• Group and Save
Author: Dr S Hirsi-Farah, Julie Comer Date: January 2015
Job Title: Consultant Obstetrician (Locum), Clinical Lead Review Date: January 2017
midwife
Policy Lead: Group Director Urgent Care Version: 1.0 ratified 9th Jan
Mat CG mtg
Location: Maternity CG Shared drive/ Intrapartum/ GL861
This document is valid only on date Last printed 02/06/2015 12:11:00 Page 32 of 63
Maternity Guidelines – Hypertesion (GL952) January 2015
Write results and time blood taken on HDU chart. If there is a flow chart in the notes
continue this as trends in the blood tests are important.
5. The on call obstetric consultant must be informed of events and asked to attend.
If there are any problems with airway management/central line or if C/S planned,
the labour ward anaesthetist must discuss the management with the on-call
Consultant anaesthetist.
6. Insert urinary catheter - for hourly urine output measurement.
7. Start input / output chart, this must be accurate as a decrease in urine output
may indicate a need for change in the management plan. Test urine for protein if
pre-eclampsia not formerly diagnosed. Urinalysis for protein is not required if the
woman is known to have pre-eclampsia.
Blood pressure:
If BP ≥ 160/110 mm Hg manage as for severe hypertension. Note that oral drugs may not
be suitable if post ictal (drowsy). Intramuscular injections are contra-indicated if the
platelet count is < 100 x 109/l. If hydralazine or Labetalol infusion is required ensure
appropriate decrease in infusion rate of IV fluids.
O2 saturation levels:
This should remain above 97%. If levels fall below this check respiratory rate every 15
minutes, inform labour ward obstetric registrar who should listen to the chest. If there is
any evidence of pulmonary oedema arrange chest x-ray then if confirmed give 20mg
intravenous furosemide. If there is evidence of pulmonary oedema on the x-ray
management must be discussed with both the obstetric and anaesthetic consultants.
Fluid Balance:
In severe pre-eclampsia there is severe intravascular depletion and a contracted vascular
bed. This means that responses to fluids may be atypical and difficult to assess.
Consequently great care with fluid balance is required as there is a real danger of fluid
overload.
The following guidelines should be observed:
• Replace obvious blood loss at delivery
• Then fluid restrict to maintain total fluid input at 40 ml per hour + previous
hour’s urine output, given as crystalloid (plasmalyte) to a maximum of 80 ml
per hour
• Do not chase a ‘satisfactory’ urine output. The patient is liable to develop
pulmonary oedema. Irreversible renal damage is unlikely after a short period
of oliguria secondary severe pre-eclampsia.
• A central line is rarely indicated unless there has been a major obstetric
Author: Dr S Hirsi-Farah, Julie Comer Date: January 2015
Job Title: Consultant Obstetrician (Locum), Clinical Lead Review Date: January 2017
midwife
Policy Lead: Group Director Urgent Care Version: 1.0 ratified 9th Jan
Mat CG mtg
Location: Maternity CG Shared drive/ Intrapartum/ GL861
This document is valid only on date Last printed 02/06/2015 12:11:00 Page 33 of 63
Maternity Guidelines – Hypertesion (GL952) January 2015
Urine output:
• If urine output is low (<100ml/ 4 hours) carefully assess fluid balance
• Repeat PET screen
• If creatinine >120mmol/l the management must be discussed with the on call
consultant. The discussion must be recorded in the case notes
Timing of delivery:
• If the woman has an eclamptic fit, she should be stabilised and then both
mother and fetus assessed for mode and timing of delivery. This will depend
upon the gestation of the fetus.
• In severe pre-eclampsia, pregnancy should not be prolonged to gain fetal
maturity at the expense of deteriorating maternal condition.
• The decision to deliver and mode of delivery will be made a senior
obstetrician in consultation with the neonatal and anaesthetic staff, following
review of the biochemistry, maternal observations & condition and gestation
of fetus.
• If the fetus is alive caesarean section is usually appropriate unless vaginal
delivery is imminent. Continuous CTG monitoring until delivery is mandatory.
• If the fetus is alive the neonatal team should be informed of the eclamptic fit,
its management and plans for birth. A paediatrician should be called to
attend the birth even if fetal compromise is not suspected.
• If the fetus has died vaginal delivery is most appropriate provided it can be
achieved within 12 hours of the eclamptic fit.
Analgesia
• Providing the clotting is normal and the platelet count > 80x109/L and there
are no other contra-indications consider an epidural for analgesia in labour,
for Caesarean section and post operatively for analgesia. Use
colloid/crystalloid carefully for co-loading. 500 ml to 1000 ml will be
sufficient.
• Take care with narcotics. These patients have a tendency to respiratory
depression.
• If epidural analgesia is not possible then consider PCA rather than IM bolus
administration.
Author: Dr S Hirsi-Farah, Julie Comer Date: January 2015
Job Title: Consultant Obstetrician (Locum), Clinical Lead Review Date: January 2017
midwife
Policy Lead: Group Director Urgent Care Version: 1.0 ratified 9th Jan
Mat CG mtg
Location: Maternity CG Shared drive/ Intrapartum/ GL861
This document is valid only on date Last printed 02/06/2015 12:11:00 Page 34 of 63
Maternity Guidelines – Hypertesion (GL952) January 2015
Coagulation control
• If there is an abnormal clotting profile or low platelet count i.e. < 80x109/L
prior to a surgical procedure, or there is clinical DIC, seek the advice of the
Consultant Haematologist on-call.
• The patient may require platelet concentrate and/or fresh frozen plasma and
cryoprecipitate transfusion.
However, if
o She remains confused
o Has rapidly evolving neurological signs
o Evidence of falling platelets or disseminated intravascular coagulation
(DIC) then a general anaesthetic should be performed
Post partum
It is common for the clinical and biochemical aspects of pre-eclampsia to deteriorate
in the 24 hr after delivery.
Complete a new VTE risk assessment if not completed within last 24 hours. Do not
give Tinzaparin during labour but start in the immediate postnatal period when it is
safe to do so. Use flowtrons until she can be given her first postnatal dose of
Tinzaparin
Physiotherapy: daily physiotherapy for prevention of DVT and chest infection in
the pueperium till mobile.
6.4 Immediate postnatal care on the labour ward of women with severe
hypertension and/or eclampsia.
1. If on MgSO4 follow MgSO4 guidelines.
2. After delivery take BP every 30 minutes for 2 hours, if BP <150/100
mmHg reduce frequency of BP measurement to 4 hourly. These
recordings must be documented on the MOWS chart. Each time the BP is
checked the woman should be asked about symptoms especially
headache and epigastric pain.
3. If BP is controlled by an infusion, continue the infusion until the registrar
has reviewed the woman and documented a change to an oral regime.
4. If the woman is on oral antihypertensive continue the pregnancy regime,
unless the regime includes methyldopa. Methyldopa should be stopped
after delivery; the registrar (or SHO after consultation with the registrar)
must document an alternative antihypertensive regime in the woman’s
notes.
5. Follow bladder care guidelines.
6. Continue to record fluid balance until discharge from labour ward, even
after catheter is removed.
7. Complete postnatal VTE risk assessment. If postnatal Tinzaparin is
required the registrar should decide when the first dose can be given –
this will depend on clinical circumstances, the platelet count and renal
function. If the postnatal dose cannot be given within 6 hours of delivery
the woman should have flowtrons fitted until the first dose of Tinzaparin is
given.
8. The use of NSAID’s for pain relief may be contraindicated in women with
pre-eclampsia. The registrar should decide (and document) if/when
NSAID’s can be given
BP≥160/110mmHg
Care Escalation to medical staff
Immediate • After delivery take BP every 30 minutes for 2 • The registrar (or SHO after
postnatal hours, if BP <150/100 mmHg reduce frequency of consultation with the registrar) must
BP measurement to 4 hourly. These recordings document an alternative
care must be documented on the MOWS chart. Each antihypertensive regime in the
time the BP is checked the woman should be woman’s notes.
asked about symptoms especially headache and
epigastric pain.
• The registrar is expected to review
the woman within 4 hours of delivery
• If BP is controlled by an infusion, continue the and document ongoing care plans.
infusion until the registrar has reviewed the He/she will decide when transfer to
woman and documented a change to an oral Iffley ward is appropriate.
regime.
• The women should be reviewed at
• If the woman is on oral antihypertensives continue least 8 hourly by the Labour Ward
the pregnancy regime, unless the regime includes registrar who should document
methyldopa. Methyldopa should be stopped after ongoing care plans.
delivery and alternative medication prescribed.
• The labour ward registrar must
• Follow bladder care guidelines. document a plan for care on
Iffley ward.
• Continue to record fluid balance until discharge • The registrar must review the
from labour ward, even after catheter is removed. woman between 1 and 2 hours after
MgS04 infusion is discontinued.
Women receiving MgS04
• Follow eclampsia pathway.
• The woman will need to be observed on labour
ward for at least 24 hours after MgS04 infusion
discontinued.
• Urine output should still be measured and
recorded on a fluid balance chart; at this stage a
catheter is not necessary.
If at any check the woman has raised blood pressure >149/99mmHg, or symptoms,
arrangements must be made for her to be reviewed at the hospital usually DAU (LW
out of hours).
If the woman is still on anti-hypertensive medication on day 12, the community
midwife must ensure that the woman’s current antihypertensive regime is clearly
documented in her handheld care plan. The woman should be reminded to take this
care plan with her when she has her two week BP review with her GP. The
community midwife will need to collect the care plan from the woman after her GP
review.
9.0 References
9.1 NICE clinical guideline 107(2010) Hypertension in pregnancy: the
management of hypertensive disorders during pregnancy
9.2 Confidential Enquiry into Maternal & Child Health CEMACH (2007) RCOG
Press The Eclampsia Trial Collaborative Group (1995). Which anticonvulsant
for Women with eclampsia? Evidence from the Collaborative Eclampsia Trial.
Lancet 345 1455-1463.
9.3 The Magpie Trial Collaborative Group (2002). Do women with pre-eclampsia,
and their babies benefit from magnesium sulphate? The Magpie Trial: a
Randomized placebo-controlled trial. The Lancet 359 1877-1890
9.4 RCOG 2006 The management of severe pre-eclampsia and eclampsia
Green top guideline 10a March
9.5 RCOG 2010 – Green Top Guideline No: 7 Antenatal Corticosteroids to
reduce neonatal Morbidity and Mortality
9.6 Chronic Hypertension in Pregnancy and the Risk of Congenital
Malformations: A Cohort Study; Bateman B, Huybrechts K, Fischer M, Seely
E, Ecker J, Oberg A, Franklin J, Mogun H, Hernandez-Diaz S; American
Journal of Obstetrics and Gynecology (Sep 2014
The above patient is an in patient with pre-eclampsia, and ideally should be delivered after 34+0
weeks. However in some circumstances earlier delivery will be considered /advised.
The woman will be reviewed by a registrar or consultant each day. It the woman’s clinical
condition deteriorates between reviews the midwives will request extra medical review. If the
clinical situation changes earlier delivery may be advised.
Acute circumstances, in which early delivery may be required include:
o Abnormal CTG
o Significant PV bleeding
o HELLP
o Refractory hypertension despite usual management
o Symptoms of deteriorating pre-eclampsia or signs of suggestive of imminent eclampsia
such as clonus. These women will require urgent transfer to the Labour Ward and
magnesium sulphate infusion before delivery.
If any of these acute events occur the woman must be urgently reviewed by a registrar, and
management discussed with either the woman’s own consultant, or the duty consultant. This
discussion should be documented in the woman’s notes by the registrar using the SBAR sticker.
Consultant name:………………………………………………………………..
Consultants signature:………………………………………………………….
Date:……………………………………………………………………………...
This form must be signed by the responsible consultant within 24 hours of admission.
The form must be kept on the clipboard at the end of the woman’s bed, and is part of her
medical record
The above patient is known to have chronic hypertension. At the end of pregnancy her anti-
hypertensive medication was: ……………………………………………………………………….
…………………………………………………………………………………………………………..
It is likely that this woman will stay on the some antihypertensive regime until she sees her GP two
weeks post delivery. The GP will then change her medication to either her pre-pregnancy regime,
or a regime that is compatible with breastfeeding.
Please check her blood pressure on Day 4 if it is <140/90mmHg and the woman does not complain
of dizziness or fainting do not arrange any further BP checks. If the woman complains of dizziness
or fainting please call DAU or the antenatal clinic, whilst you are with the woman, for advice.
If the blood pressure is 141/91 – 150/100mmHg please check her blood pressure every 2 days
until it is less than 140/90mmHg.
If the blood pressure is >150/100mmHg please call DAU or the antenatal clinic, whilst you are with
the woman, for advice. Women with chronic hypertension do not need to be readmitted to hospital
unless there are other concerns. If the woman’s antihypertensive medication is increased you will
need to check the blood pressure again the following day.
It is your responsibility to clearly document changes in medication in the woman’s hand held care
plan.
Please remind the lady that is she is taking antihypertensive medication she will need to arrange a
GP check up at 2 weeks. The woman should take her care plan with her to this appointment, so
that the GP knows what her current regime is (the GP will have a letter off her discharge regime
already) .
Please collect the care plan from the woman after her GP review.
Women with gestational hypertension, and controlled blood pressure, will usually be discharged
home 48 hours after birth. If they are on antihypertensive medication they are likely to be taking
Labetalol and/or Nifedipine. If the woman is on any other antihypertensive drugs then her post
natal blood pressure checks need to be arranged in DAU. Otherwise the woman’s blood pressure
will be managed by the community midwife, following the regimes below.
Please check the blood pressure on day 4 and then on alternate days until the woman is off
medication. If the woman is still on medication 12 days after delivery she must be told to arrange
an appointment with her GP on day 13/14. If day 13/14 is over the weekend the woman will need
to see her GP on Day 12 as the TTO medications are only prescribed for 14 days. Her GP should
then manage her medication, and will be responsible for prescribing any ongoing antihypertensive
medication.
If at any check the woman has blood pressure >149/99mmHg please arrange for her to be
reviewed at the hospital (DAU or LW out of hours).
If the woman’s blood pressure is 130/80 – 149/99mmHg please advise the woman to continue on
her current regime.
It the woman’s blood pressure is <130/80mmHg please advise the woman to decrease her
antihypertensive medication following the plan below. Please then review the blood pressure
again 2 days later. If you stop the medication, as instructed on the plan below, you should then
check the blood pressure again 2 days later.
If the woman is on more than 1 antihypertensive drug you should follow the reducing regime for
one drug, until it has been stopped, before decreasing the other drug. Clinically it does not matter
which drug is reduced first.
If the woman is still on antihypertensive medication on Day 12 please ensure the woman’s current
antihypertensive regime is clearly documented in her hand held care plan. The woman should be
reminded to take this care plan with her when she has her 2 weeks BP review with her GP. Please
remember to collect the care plan from the woman after her GP review.
Women with mild pre-eclampsia (not on medication) will be discharge home from hospital on day
2. The community midwife should take a blood pressure and check for symptoms on day 3, 4,and
6. If the woman is symptom free and the BP is <150/100mmHg no further action is required. If the
woman has raised blood pressure or symptoms arrangements must be made for her to be
reviewed at the hospital, usually DAU.
Women with pre-eclampsia on antihypertensive medication will be managed in hospital until day 4.
If she is on antihypertensive medication she is likely to be taking Labetalol and/or Nifedipine. If the
woman is on any other antihypertensive drugs then her post natal blood pressure checks need to
be arranged in DAU. Otherwise the woman’s blood pressure will be managed by the community
midwife, following the regimes below.
Please check the blood pressure 2 days after discharge from hospital and then on alternate days
until the woman is off medication. If the woman is still on medication 12 days after delivery she
must be told to arrange an appointment with her GP on day 13/14. If day 13/14 is over the
weekend the woman will need to see her GP on day 12 as the TTO medications are only
prescribed for 14 days. Her GP should then manage her medication, and will be responsible for
prescribing any ongoing antihypertensive medication.
If at any check the woman has raised blood pressure >149/99mmHg, or symptoms, arrangements
must be made for her to be reviewed at the hospital, usually (DAU or LW out of hours).
If the woman’s blood pressure is 130/80 – 149/99mmHg please advise the woman to continue on
her current regime.
It the woman’s blood pressure is <130/80mmHg please advise the woman to decrease her
antihypertensive medication following the plan below. You should then review the blood pressure
again 2 days later. If you stop the medication, as instructed on the plan below, you should then
check the blood pressure again 2 days later.
If the woman is on more than 1 antihypertensive drug you should follow the reducing regime for
one drug, until it has been stopped, before decreasing the other drug. Clinically it does not matter
which drug is reduced first.
If the woman is still on antihypertensive medication on day 12 please ensure the woman’s current
antihypertensive regime is clearly documented in her hand held care plan. The woman should be
reminded to take this care plan with her when she has her 2 weeks BP review with her GP. Please
remember to collect the care plan from the woman after her GP review.
Your patient delivered her baby at Royal Berkshire NHS Foundation Trust
on………………………………….
o Pre-eclampsia (PET)
o Gestation (PIH)
Please send her urgently to the Day Assessment Unit if she has any NEW
symptoms suggestive of poorly controlled hypertension (>150/100 mmHg despite
adequate treatment), pre-eclampsia or impending eclampsia
o At 2/52 postnatal to check her blood pressure with a view tailing off
/stoppingher medication.
Please tell women who had pre-eclampsia that their risk of recurrence is for:
gestational hypertension ranges from about 1 in 8 (13%) to about 1 in 2
(53%) pregnancies
Tell the woman that these conditions are associated with an increased risk of developing high
blood pressure and its complications in later life (cardiovascular disease or kidney disease or
stroke)
Advise women who have had hypertension in pregnancy they can modify the risk of cardiovascular
disease by stopping smoking, eating a healthy diet including keeping dietary sodium intake low
(either by reducing or substituting sodium salt), taking regular exercise and losing weight if you are
overweight and keeping their BMI within the healthy range.
Stop antihypertensive treatment in women taking ACE inhibitors or ARBs if they become
pregnant (preferably within 2 working days of notification of pregnancy) and offer alternatives
(labetalol or methyldopa)
Advise these women in their subsequent pregnancies to take 75 mg of aspirin daily from 12
weeks until delivery
………………………………………………………………………………….
Yours Sincerely,
At 2/52 postnatal had BPchecked by her GP and medications were tailed off /stopped.
Needs repeat PET bloods (persist proteinuria or hypertension, abnormal result at discharge)
pre-eclampsia is up to about 1 in 6 (16%) pregnancies, but if their pre- eclampsia was complicated
by severe pre-eclampsia, HELLP syndrome or eclampsia and led to birth before 34 weeks the risk
• The risk of developing high blood pressure and its complications in later life is increased
(cardiovascular disease or stroke)
• Advise women who have had hypertension in pregnancy they can modify the risk of
cardiovascular disease by stopping smoking, eating a healthy diet including keeping dietary
sodium intake low (either by reducing or substituting sodium salt), taking regular exercise
and losing weight if you are overweight and keeping their BMI within the healthy range.
• Advice on safe alternative antihypertensive treatment for next pregnancy and what to do if
they are taking ACE inhibitors or ARBs and they become pregnant
• Advise on the need to take 75 mg of aspirin daily from 12 weeks until delivery in their
subsequent pregnancies
……………………………………………………………………………………………………………
Chronic hypertension
(hypertension at
booking or ≤ 20
weeks or if already
on antihypertensive Labetalol Methyldopa
Nifedipine
therapy) (centrally acting)
(mixed alpha and beta
(Adalat®Retard)
Gestational blocker) dose: dose:
hypertension (new dose:
100mg BD increasing to 250mg TDS increasing to
hypertension 10mg BD to a max 80mg
a max 800mg a day in max 3g a day in divided
≥ 20 weeks without a day in divided doses
divided doses doses
significant Nifedipine is not licensed
Labetalol is licensed for Methyldopa is licensed
proteinuria) for use in pregnancy
use in pregnancy for use in pregnancy
Pre-eclampsia
(new hypertension
≥ 20 weeks with
significant
proteinuria)
Contraindications: Contraindications: Contraindications:
Asthma, bradycardia, Liver disease, Advanced aortic
pulmonary oedema depression, acute stenosis,
Comment Side effects: porphyria Side effects:
Maternal bradycardia, Side effects: Headache, flushing
tiredness Drowsiness, depression
Caution: DM
• If on pre-conception
AHT ensure use of
a drug that reduces
fetal risks and
maternal side effect • Use AHT to keep: • Use AHT to keep:-
Treat profiles BP <150mmHg BP <150mmHg systolic
• Aim for a BP of < systolic BP 80- BP 80-100mmHg
150/100mmHg 100mmHg diastolic diastolic
• Consider antenatal
referral to a HT
specialist/obstetric
medicine clinic
BP measurement
• Severe – BP check
Mild: 4 x a day
• If BP controlled at • Mild x 1 week
140-149/ 90-99 booking (<150/100)
• Moderate x 2 • Mild x 3/week
Moderate: measure BP 2-4
week • Moderate 4hrs
weekly. If it remains
150-159/100-109 • Severe > x 4 a • Severe 4hrs
controlled then
day
increase frequency
Severe:
depending on
>160/110 clinical picture
Blood tests
(FBC, U&E, • At Booking • Test at
• PET bloods 2-3 x
Creatinine, LFT’s • No need to repeat if presentation for
week depending on
normal unless mod/severe HT
and Clotting if signs/symptoms of • Re-test depending
clinical
circumstances
platelets < superimposed PET on clinical picture
100x109/L
Aim to keep BP
= 140/90 Review long- term
4 hourly 1st day Continue AN AHT AHT at 2 weeks
Daily 2nd day treatment (change if on Offer follow- up with
Chronic
At least once during days methyldopa within 2 pre- pregnancy
Hypertension
3-5 as clinically indicated days of birth and re- medical team at 6-8
start pre-pregnancy AHT weeks for long-term
if safe for breastfeeding) BP follow-up
Continue AN AHT
treatment (change if on
methyldopa within 2 If on AHT offer medical
days of birth) review at 2 weeks
4 hourly 1st day
If BP ≤140/90 consider If on AHT at 2 weeks
Daily 2nd day
Gestational reducing dose offer medical review
At least once during days
Hypertension Reduce dose if BP ≤ at 6-8 weeks
3-5 as clinically indicated
130/80 If on AHT at 6-8 weeks
If previously untreated offer specialist referral
and BP ≥ 149/99
consider starting AHT
Notes:
For all babies whose mothers are taking AHT in the postnatal period asses well being of the
baby especially adequacy of breastfeeding at least daily for the first 2 days after birth
Insufficient evidence on the safety of
ARB (Angiotensin receptor blockers)
Amlodipine
ACE other then Enalapri/ Captopril