Beruflich Dokumente
Kultur Dokumente
Ruth F. Padmore, MD, FRCPC, PhD,
Associate Professor, University of Ottawa
Staff Hematopathologist, The Ottawa Hospital and Eastern Ontario
Regional Laboratory Association
Disclosures
Disclosures
1
2019‐04‐08
Objectives
Morphology of malaria: Plasmodium falciparum
Mature schizont
Mature trophozoite
Release of merozoites
Asexual cycle to become gametocytes
in human RBC
Release of merozoites
to become new ring forms
Ring form trophozoite Gametocyte
Sexual form:
To mosquito
Plasmodium falciparum
Ring form trophozoites
with double chromatin
dots (headphone cells)
2
2019‐04‐08
Plasmodium falciparum
Multiple rings in one red blood cell
Plasmodium falciparum
Mature schizonts
Plasmodium falciparum
Maurer’s clefts
CDC Division of Parasitic Diseases https://www.cdc.gov/dpdx/malaria/
3
2019‐04‐08
Plasmodium falciparum
Macrogametocytes
Plasmodium falciparum
Microgametocytes
Plasmodium falciparum
Thick film
Mature schizont
Ring form trophozoites
Gametocyte
4
2019‐04‐08
Ameboid trophozoite Mature schizont
with Schüffner's dots* Release of merozoites
to become gametocytes
Asexual cycle Release of merozoites
in human RBC to become new ring forms
Ring form trophozoite Gametocyte
Sexual form:
To mosquito
*CDC Division of Parasitic Diseases https://www.cdc.gov/dpdx/malaria/
Plasmodium vivax
Ameboid trophozoites
Plasmodium vivax
Ameboid trophozoite
Immature schizont
5
2019‐04‐08
Plasmodium vivax
Maturing schizont
Gametocyte
Maturing trophozoite Mature schizont
with fimbriation Release of merozoites
to become gametocytes
Asexual cycle Release of merozoites
in human RBC to become new ring forms
Ring form trophozoite
Gametocyte
Sexual form:
To mosquito
Plasmodium ovale
Ring form trophozoites
with prominent chromatin dot
6
2019‐04‐08
Plasmodium ovale
Morphology of malaria:
Plasmodium malariae
“Daisy head”
mature schizont
Band form
maturing trophozoite* Release of merozoites
to become gametocytes
Asexual cycle Release of merozoites
in human RBC to become new ring forms
“Bird’s eye” Gametocyte
ring form trophozoite* Sexual form:
To mosquito
*CDC Division of Parasitic Diseases https://www.cdc.gov/dpdx/malaria/
Plasmodium malariae
Mature schizont releasing
merozoites
Gametocytes with
reduction in red cell size
7
2019‐04‐08
Morphology of malaria:
Plasmodium knowlesi
Mature schizont*
Band form
maturing trophozoite* Release of merozoites
to become gametocytes
Asexual cycle Release of merozoites
in human RBC to become new ring forms
Ring form trophozoite* Gametocyte*
Sexual form:
Van Hellemond J et al. Emerg Inf Dis 15(9):1478‐1480; 2009* To mosquito
https://wwwnc.cdc.gov/eid/article/15/9/pdfs/09‐0358.pdf
Thrombocytopenia and
large reactive lymphocyte
with immunoblastic morphology
in malaria infection
Babesiosis
8
2019‐04‐08
Babesiosis Babesiosis
Babesiosis
Extracellular ring forms
Undulating membrane
Flagellum
9
2019‐04‐08
Trypanosoma cruzi
Chagas’s disease
Microfilaria: Loa loa
Microfilaria: Mansonella perstans
10
2019‐04‐08
Disseminated histoplasmosis diagnosed by peripheral blood
film in a patient with chronic lymphocytic leukaemia. Zhaodong Xu, Greg
German, Peter Jessamine, Janis Bormanis, Antonio Giulivi and Ruth Padmore
bjh images in haematology, British Journal of Haematology, 2013, 162, 572
MMWR May 13, 2016
“All material in the MMWR Series is in the public domain and may be used and reprinted
without permission; citation as to source, however, is appreciated.”
Tick borne relapsing fever: (Borrelia species)
Spirochetes
Image from CDC
https://www.cdc.gov/relapsing‐fever/clinicians/
11
2019‐04‐08
Spherocytic hemolysis due
to Clostridium perfringens
https://www.islh.org/ISLH‐Education/cases.php
Lymphocytosis due to
Bordetella pertussis
Lymphocytosis due to
Bordetella pertussis
12
2019‐04‐08
Lymphocytosis due to
infectious mononucleosis
with apoptotic lymphocyte
Question 1.
Question 1.
13
2019‐04‐08
Question 2.
Question 2.
Question 3.
14
2019‐04‐08
Question 3.
Question 4.
What does this 1.
photomicrograph show?
(choose the best answer)
a)1 = Ehrlichia
2 = Babesiosis
b)1 = Platelet clumps
2 = Babesiosis
2.
c) 1 = Ehrlichia
2 = Plasmodium falciparum
d)1 = Platelet clumps
2 = Plasmodium falciparum
Question 4.
What does this 1.
photomicrograph show?
(choose the best answer)
a)1 = Ehrlichia
2 = Babesiosis
b)1 = Platelet clumps
2.
2 = Babesiosis
c) 1 = Ehrlichia
2 = Plasmodium falciparum
d)1 = Platelet clumps
2 = Plasmodium falciparum
15
2019‐04‐08
Questions ?
16