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No.

Protein Gene G kusuG bur IC50 Drug


1 Macrophage colony-stimulating factor receptor CSF1R/FMS -11.53 -10.37 16.8 Pazopanib
2 Macrophage metalloelastase MMP12 -11.21
3 Heat shock protein 90 alpha HSP90A -10.73 -8.73 0.0047 Luminespib
4 CyclinB CCNB -10.58 -9.46
5 Mitogen-activated protein kinase kinase MEK1/MAPKK1 -10.41 -9.23 0.82 PD0325901
6 Receptor interacting protein kinase RIPK1 -10.32 159 XMD13-2
7 Adenylate cyclase 10 ACDY10 -10.31
8 Matrix metallopeptidase 9 MMP9 -10.14
9 Heat shock protein 90 beta HSP90B -10.09 -8.41 0.0047 Luminespib
10 Ras-related protein RAP1A -9.95
11 Ras homolog gene family, member RHOA -9.88 -15.68
12 Sphingosine Kinase 1 SPHK1 -9.81 -12.87
13 cAMP response element binding protein CREP -9.74
14 Ras-related protein in brain 31 RAB31 -9.69
15 Activated CDC42 kinase 1 ACK1 -9.66 -7.02
16 Activin type 2 receptors ACVR2 -9.61 -7.59
17 Insulin-like growth factor (IGF) binding proteins IGFR -9.58
18 Prostaglandin G/H synthase 2 Ptgs2/COX2 -9.56 -7.91
19 Retinoid X receptor alpha (RXR-alpha), (nuclear receptor subfamilyNR2B1
2, group B,-9.53
member 1) 14.1 Bexarotene
20 Hematopoietic cell kinase HCK -9.51 -7.07
21 Phosphoinositide-dependent kinase-1 PDK1 -9.47 -9.49 1.18 OSU-03012
22 Cyclin-dependent kinases 1 CDK1 -9.41 -8.21 7.33 RO-3306
23 Focal adhesion kinase 1 FAK1/PTK2 -9.41 -9.71 3.14 PF-562271
24 Mitogen-Activated Protein Kinase Kinase Kinase 8 MAP3K8 -9.41 212 KIN001-266
25 Ras-related C3 botulinum toxin substrate 1 precursor RAC1 -9.34 11.7 EHT-1864
26 Protein kinase A PKA -9.23 -7.92
27 Histone deacetylase 7 HDAC7 -9.21 -7.16
28 Endothelial nitric oxide synthase/eNOS NOS3 -9.21 -7.97
29 Tropomyosin receptor kinase A TRKA -9.2
30 Androgen receptor AR -9.19 -8.69 7.54 Bicalutamide
31 Calcium/calmodulin-dependent protein kinase 2 alpha CAMK2A -9.15 159 XMD15-27
32 Protein kinase C PKC -9.14 -8.44 0.0204 Bryostatin 1
33 Prostaglandin G/H synthase 2 Ptgs2/COX2 -9.14 -10.26
34 Topoisomerase II beta TOP2B -9.13 -6.47 0.965 Etoposide
35 Cyclin-dependent kinases 2 CDK2 -9.12 -7.69 84.9 AT-7519
36 Platelet-derived growth factor receptors beta PDGFRB -9.1 141 Masitinib
37 Activin A receptor, type I ACVR1 -9.06 -7.5
38 Glycogen synthase kinase-3beta GSK3B -9.04 -8.02 8.77 CHIR-99022
39 Cell division cycle protein 20 CDC20 -9.03
40 Zinc finger protein SNAI1 SNAI1/SNAH -9.03
41 Receptor tyrosine kinases RTK -9.02
42 Protein tyrosine phosphatase, non-receptor type 1 PTPN1 -9
43 Fibroblast growth factor receptor 1 FGFR1 -8.98 7.36 PD173074
44 CyclinA CCNA -8.94 -7.57
45 TGF-beta receptor I TGFBR1 -8.91 -7.91
46 Checkpoint kinase 1 CHEK1 -8.88 -11.13 5.11 AZD7762
47 Mitogen-activated protein kinase 10 MAPK10/JNK3 -8.87 -7.29 0.314 JNK-9L
48 MARKAP MARKAP -8.85
49 Nuclear factor kappa beta NFKB1 -8.85
50 SURVIVIN BIRC5 -8.84 -11 0.413 Sepantronium bromide
51 Cyclin-dependent kinases 5 CDK5 -8.83 159 PHA-793887
52 Adenylate Kinase 1 AK1 -8.8
53 FKBP51 FKBP51 -8.79
54 GTPase Hras HRAS -8.77 -8.31
55 hypoxia-inducible factor 1 HIF1 -8.76
56 Estrogen receptor alpha ESR1 -8.74 -13.25 7.09 Tamoxifen
57 GATA Binding Protein 3 GATA3 -8.73
58 72 kDa type IV collagenase MMP2 -8.67 -8.5
59 KRAS KRAS -8.64
60 Vascular endothelial growth factor receptor 2 VEGFR2 -8.64 -8.48 1.98 Tivozanib
61 MAPK14 MAPK14 -8.62 -6.91
62 Polo-like kinase 1 PLK1 -8.6 -7.91
63 Murine double minute 2 MDM2 -8.57 -10.46 5.61 Nutlin-3a (-)
64 Serine/threonine-protein kinase 16 STK16 -8.53 -8.94
65 Abl Protein Tyrosine Kinase ABL -8.49 -8.79 0.924 Ponatinib
66 Receptor-interacting serine/threonine-protein kinase 2 RIPK2 -8.49 -12.74
67 Insulin-like growth factor 1 receptor precursor IGF1R -8.48 0.0965 BMS-754807
68 p38 MAPK14 -8.42 -7.11 30.3 VX-702
69 NF-kappaB-inducing kinase NIK -8.41
70 Janus kinase 3 JAK3 -8.4 -8.7 157 WHI-P97
71 Human epidermal growth factor receptor 2 HER2/ERBB2 -8.37 -7.77 3.19 Afatinib
72 p21-activated kinase 4 PAK4 -8.35 -8.71
73 RET RET -8.33 -7.76
74 PI3K gamma PIK3CG -8.29 -8.35 0.0487 Dactolisib
75 Epidermal growth factor receptor EGFR -8.28 -11.44 2.83 Gefitinib
76 Human epidermal growth factor receptor 3 HER3/ERBB3 -8.28
77 Tyrosine-protein kinase ITK -8.27 -7.79
78 CREB binding protein CREBBP -8.21 -4.48
79 Breast Cancer genes 1 BRCA1 -8.16 -8.1
80 Fms like tyrosine kinase 3 FLT3 -8.15 -12.49 1.16 Lestaurtinib
81 Aurora A AURKA -8.14 -8.01 18.1 ZM447439
82 Hepatocyte growth factor receptor (HGFR) or MET MET -8.13
83 ROS Proto-Oncogene 1 ROS1 -8.11 -8.38
84 p21-activated kinase 1 PAK1 -8.05 3.33 IPA-3
85 Checkpoint kinase 2 CHEK2 -8.01 -9.21 5.11 AZD7763
86 Janus kinase 1 JAK1 -7.95 -6.89 46.6 Ruxolitinib
87 Axin1 AXIN1 -7.83
88 Urokinase-type plasminogen activator PLAU -7.8
89 Cell division cycle 25B CDC25B -7.77 -6.8
90 Glyceraldehyde 3-phosphate dehydrogenase GAPDH -7.73
91 c-Src SRC -7.71 -7.83 19.9 WZ3105
92 RAD51 a member of the RAD51 protein family radA -7.65 -4.99
93 Phosphatase and tensin homolog PTEN -7.63 -7.16
94 X-linked inhibitor of apoptosis protein XIAP -7.59 -6.31 7.31 Embelin
95 Bcl-2-like protein 1/Bcl-xl BCL2L1/BCLX -7.5 -6.21 0.0111 Obatoclax Mesylate
96 Spleen tyrosine kinase SYK -7.49 1.16 BAY-61-3606
97 Smoothened homolog precursor SMO -7.4 154 Vismodegib
98 Growth factor receptor-bound protein 2 GRB2 -7.38 -10.93
99 Alpha serine/threonine-protein kinase 1 AKT1 -7.37 -11.81 2.44 MK-2206
100 Son of Sevenless SOS -7.28 -7.86
101 Cyclin-dependent kinases 6 CDK6 -7.23 1.49 Palbociclib
102 Baculoviral IAP repeat-containing protein 2 BIRC2 -7.2 -13.29
103 Mast/stem cell growth factor receptor KIT/SCFR -7.2 -8.46 1.18 Amuvatinib
104 Cyclin-dependent kinases 7 CDK7 -7.15 29.8 THZ-2-102-1
105 c-SRC SRC -7.15 -9.08 19.9 WZ3105
106 Signal transducer and activator of transcription 3 STAT3 -7.14 -6.24
107 Histone Deacetylase2 HDAC2 -7.07 -12.11 0.324 JQ12
108 Peroxisome proliferator-activated receptor gamma PPARG -7.07 2.77 FH535
109 Extracellular signal–regulated kinases MAPK1/ERK2 -6.97 -8.15 79.3 VX-11e
110 Activating transcription factor 2 ATF2 -6.91
111 Prostaglandin E PGE -6.91 -7.79
112 Protein inhibitor of NOS PIN -6.87
113 E-Cadherin CDH1 -6.8 -6.52
114 p53 TP53 -6.78 -7.38
115 Fas-Associated protein with Death Domain FADD -6.56
116 B-cell lymphoma 2 BCL2 -6.41 -10.32 0.0111 Obatoclax Mesylate
117 b-tubulin TUBB -6.21 -8.22
118 Finkel-Biskis-Jinkins osteosarcoma/c-Fos FOS -4.57 -5.39
119 b-Catenin CTNNB -4.32 -4.55
120 Multidrug resistance protein 1 ABCB1
121 Canalicular multispecific organic anion transporter 2 ABCC3
122 Actin-related protein 3B ACTR3B
123 Adhesion G-protein coupled receptor G6 ADGRG6
124 Aldo-keto reductase family 1 member B1 AKR1B1
125 Alpha serine/threonine-protein kinase 2 AKT2 2.44 MK-2206
126 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1
127 Anillin ANLN
128 AP-2 complex subunit beta AP2B1
129 ADP-ribosylation factor GTPase-activating protein 1 ARFGAP1 3.52 QS11
130 Sarcoplasmic/endoplasmic reticulum calcium ATPase /SERCA ATP2A 0.000509 Thapsigargin
131 Lysophosphatidylcholine acyltransferase 1 AYTL2/LPCAT1
132 Zinc-alpha-2-glycoprotein AZGP1
133 BAG1 BAG1
134 Bcl-2-binding component 3 BBC3/PUMA
135 Bcl-2-like protein 2/Bcl-w BCL2L2/BCLW 0.0111 Obatoclax Mesylate
136 Biliverdin reductase A BLVRA
137 Bromodomain-containing protein 2 BRD2 0.861 JQ1
138 Bromodomain-containing protein 3 BRD3 0.861 JQ1
139 Bromodomain-containing protein 4 BRD4 0.861 JQ1
140 Bromodomain testis-specific protein BRDT 0.861 JQ1
141 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta BUB1B
142 Protein C10 C12orf57/C10
143 Procaspase-3 CASP3 4.99 PAC-1
144 Procaspase-7 CASP7 4.99 PAC-1
145 MTORC1 CASTOR1 0.486 AZD8055
146 MTORC2 CASTOR2 0.486 AZD8055
147 G1/S-specific cyclin-E1 CCNE1
148 G1/S-specific cyclin-E2 CCNE2
149 Macrosialin CD68
150 Serine/threonine-protein kinase MRCK alpha CDC42BPA
151 Cell division control protein 6 homolog CDC6
152 Cell division cycle-associated protein 7 CDCA7/JPO1
153 Cadherin-3 CDH3
154 Cyclin-dependent kinases 4 CDK4 1.49 Palbociclib
155 Carcinoembryonic antigen-related cell adhesion molecule 5 CEACAM5
156 Histone H3-like centromeric protein A CENPA
157 Centromere protein F CENPF
158 Centrosomal protein of 55 kDa CEP55
159 COX assembly mitochondrial protein 2 homolog CMC2
160 Collagen alpha-2(IV) chain COL4A2
161 Cathepsin L2 CTSL2
162 CXXC-type zinc finger protein 5 CXXC5
163 Deoxycytidine kinase DCK
164 L-dopachrome tautomerase DCT
165 7-dehydrocholesterol reductase DHCR7
166 Probable ATP-dependent RNA helicase DHX58 DHX58
167 ATP-dependent RNA helicase A DHX9 4.48 YK-4-279
168 Protein diaphanous homolog 3 DIAPH3
169 Denticleless protein homolog DTL
170 Transcription factor COE4 EBF4
171 Enoyl-CoA delta isomerase 2, mitochondrial ECI2
172 Protein ECT2 ECT2
173 EGLN1 EGLN1 1.37 IOX2
174 Egl nine homolog 1 EGLN1
175 DNA excision repair protein ERCC-1 ERCC1
176 Endothelial cell-specific molecule 1 ESM1
177 Exonuclease 1 EXO1
178 Exostosin-1 EXT1
179 Focal adhesion kinase 2 FAK2/PTK2B 3.14 PF-562271
180 Fibroblast growth factor 18 FGF18
181 Fibroblast growth factor 2 FGF2
182 Fibroblast growth factor receptor 3 FGFR3 7.36 PD173075
183 Fibroblast growth factor receptor 4 FGFR4
184 Farnesyl-transferase (FNTA) FNTA 0.195 Tipifarnib
185 Hepatocyte nuclear factor 3-alpha FOXA1
186 Forkhead box protein C1 FOXC1
187 GMP synthase [glutamine-hydrolyzing] GMPS
188 Guanine nucleotide-binding protein G(z) subunit alpha GNAZ
189 Probable G-protein coupled receptor 160 GPR160
190 Integral membrane protein GPR180 GPR180
191 Growth factor receptor-bound protein 7 GRB7
192 Glycogen synthase kinase-3alpha GSK3A 8.77 CHIR-99021
193 Glutathione S-transferase Mu 1 GSTM1
194 Glutathione S-transferase Mu 3 GSTM3
195 Glutathione S-transferase P GSTP1
196 Histone Deacetylase2 HDAC1 0.0239 Dacinostat
197 HLA class II histocompatibility antigen, DRB1-15 beta chain HLA-DRB1
198 Homeobox protein Hox-B13 HOXB13
199 Phospholipid-metabolizing enzyme A-C1/HRSL1 HRASLS
200 Insulin-like growth factor-binding protein 5 IGFBP5
201 Interleukin-17 receptor B IL17RB
202 Interleukin-6 receptor subunit beta IL6ST
203 Lysine-specific demethylase 7A KDM7A
204 kinesin spindle protein KIF11 1.69 Ispinesib Mesylate
205 Kinesin-like protein KIF2C KIF2C
206 Keratin, type I cytoskeletal 14 KRT14
207 Keratin, type I cytoskeletal 17 KRT17
208 Keratin, type I cytoskeletal 5 KRT5
209 Protein lin-9 homolog LIN9
210 Tyrosine-protein kinase Lyn LYN
211 Mitogen-activated protein kinase 8 MAPK8/JNK1 1.24 AS601245
212 Mitogen-activated protein kinase 9 MAPK9/JNK2 0.314 JNK-9L
213 Microtubule-associated protein tau MAPT
214 Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1 0.0111 Obatoclax Mesylate
215 DNA replication licensing factor MCM6 MCM6
216 Dual specificity mitogen-activated protein kinase kinase 2MEK2/MAPKK2 0.82 PD0325902
217 Maternal embryonic leucine zipper kinase MELK
218 Matrix Gla protein MGP
219 Melanoma-derived growth regulatory protein MIA
220 microRNA-21 MIR21
221 Proliferation marker protein Ki-67 MKI67
222 DNA mismatch repair protein Mlh1 MLH1
223 Melanophilin MLPH
224 Stromelysin-3 MMP11
225 Membrane-spanning 4-domains subfamily A member 7 MS4A7
226 Myb/SANT-like DNA-binding domain-containing protein 3 MSANTD3
227 Protein LYRIC MTDH
228 Mammalian target of rapamycin MTOR 0.311 Temsirolimus
229 Myb-related protein B MYBL2
230 Myc proto-oncogene protein MYC
231 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.274 Pevonedistat
232 Nicotinamide phosphoribosyltransferase NAMPT 0.0799 Daporinad
233 Arylamine N-acetyltransferase 1 NAT1
234 Kinetochore protein NDC80 homolog NDC80
235 Kinetochore protein NDC80 homolog NDC80
236 Protein NDRG1 NDRG1
237 Serine/threonine-protein kinase Nek2 NEK2
238 N-myristoyltransferase 1 NMT1 1.57 ICL1100013
239 N-myristoyltransferase 2 NMT2 1.57 ICL1100014
240 Neuromedin-U NMU
241 High affinity nerve growth factor receptor NTRK1 5.04 GW441756
242 Kinetochore protein Nuf2 NUF2
243 Nucleolar and spindle-associated protein 1 NUSAP1
244 Origin recognition complex subunit 6 ORC6
245 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial OXCT1
246 Paralemmin-2 PALM2
247 Poly [ADP-ribose] polymerase 1 PARP1 3.01 Talazoparib
248 Poly [ADP-ribose] polymerase 2 PARP2 3.01 Talazoparib
249 Platelet-derived growth factor receptors alpha PDGFRA 1.18 Amuvatinib
250 Progesterone receptor PGR
251 D-3-phosphoglycerate dehydrogenase PHGDH
252 PI3K beta PIK3CB 2.58 AZD6482
253 Presequence protease, mitochondrial PITRM1
254 Peroxisome proliferator-activated receptor delta PPARD 2.77 FH535
255 Protein phosphatase 1D PPM1D 3.62 CCT007093
256 Protein phosphatase 1 regulatory subunit 12A PPP1R12A
257 Protein regulator of cytokinesis 1 PRC1
258 Securin PTTG1
259 Sulfhydryl oxidase 2 QSOX2
260 Ras-related protein Rab-6B RAB6B
261 Ras-related C3 botulinum toxin substrate 2 RAC2
262 Ras-related C3 botulinum toxin substrate 3 RAC3
263 Rac GTPase-activating protein 1 RACGAP1
264 Ras association domain-containing protein 7 RASSF7
265 DNA endonuclease RBBP8 RBBP8
266 ATP-dependent DNA helicase Q5 RECQL5
267 Transcription factor p65 RELA
268 Replication factor C subunit 4 RFC4
269 Rho-associated protein kinase 1 ROCK1 3.79 GSK269962A
270 Rho-associated protein kinase 2 ROCK2 3.79 GSK269962A
271 Ribonucleoside-diphosphate reductase subunit M2 RRM2
272 Ribonucleoside-diphosphate reductase subunit M2 RRM2
273 Reticulon-4 receptor-like 1 RTN4RL1
274 RUN domain-containing protein 1 RUNDC1
275 Signal peptide, CUB and EGF-like domain-containing protein 2 SCUBE2
276 Small EDRK-rich factor 1 SERF1A
277 Secreted frizzled-related protein 1 SFRP1
278 SGK2 SGK2 1.42 GSK650394
279 SGK3 SGK3 1.42 GSK650395
280 Solute carrier family 2, facilitated glucose transporter member 3 SLC2A3
281 Zinc transporter ZIP6 SLC39A6
282 Large neutral amino acids transporter small subunit 1 SLC7A5/LAT1
283 Stanniocalcin-2 STC2
284 Serine/threonine-protein kinase 32B STK32B
285 TAK1 TAK1 3.28 (5Z)-7-Oxozeaenol
286 Telomerase reverse transcriptase TERT
287 Transforming growth factor beta-3 proprotein TGFB3
288 Transmembrane protein 45B TMEM45B
289 Transmembrane protein 74B TMEM74B
290 Topoisomerase I TOP1 0.0079 SN-38
291 TRAIL receptor agonist TRAILR 1.37 rTRAIL
292 tRNA (uracil-5-)-methyltransferase homolog A TRMT2A
293 Testis-specific Y-encoded-like protein 5 TSPYL5
294 a-tubulin TUBA -6.38
295 Thymidylate synthase TYMS
296 Ubiquitin-conjugating enzyme E2 C UBE2C
297 Ubiquitin-conjugating enzyme E2 T UBE2T
298 Ubiquitin carboxyl-terminal hydrolase isozyme L5 UCHL5
299 Vascular endothelial growth factor receptor 1 VEGFR1/FLT1 1.98 Tivozanib
300 WEE1 WEE1 3.28 Wee1 Inhibitor
301 WAP four-disulfide core domain protein 2 WFDC2
302 WNT1-inducible-signaling pathway protein 1 WISP1/CCN4
303 Zinc finger protein 385B ZNF385B