Supplement to

T HE J OURNAL OF

Allergy Clinical AND

Immunology
VOLUME 125  NUMBER 2

OFFICIAL JOURNAL OF THE AMERICAN ACADEMY OF ALLERGY, ASTHMA & IMMUNOLOGY

2010 Primer on Allergic and Immunologic Diseases

Preface to the 2010 Primer on Allergic and Immunologic Diseases S1
William T. Shearer, MD, PhD, and Donald Y. M. Leung, MD, PhD, Associate Editor, Houston, Tex, and Denver, Colo

Chapter 1: Overview of the immune response S3

David D. Chaplin, MD, PhD, Birmingham, Ala

Chapter 2: Innate immunity S24

Stuart E. Turvey, MB, BS, DPhil, and David H. Broide, MB, ChB, Vancouver, British Columbia, Canada, and La Jolla, Calif

Chapter 3: Adaptive immunity S33

Francisco A. Bonilla, MD, PhD, and Hans C. Oettgen, MD, PhD, Boston, Mass

Chapter 4: Structure and function of immunoglobulins S41

Harry W. Schroeder, Jr, MD, PhD, and Lisa Cavacini, PhD, Birmingham, Ala, and Boston, Mass

Chapter 5: Immunologic messenger molecules: Cytokines, interferons, and chemokines S53

Scott P. Commins, MD, PhD, Larry Borish, MD, and John W. Steinke, PhD, Charlottesville, Va

Chapter 6: IgE, mast cells, basophils, and eosinophils S73

Kelly D. Stone, MD, PhD, Calman Prussin, MD, and Dean D. Metcalfe, MD, Bethesda, Md

Chapter 7: Genetics of allergic disease S81

John W. Holloway, PhD, Ian A. Yang, MBBS, PhD, and Stephen T. Holgate, MD, DSc, FMed Sci, Southampton, United Kingdom, and
Brisbane, Australia

Chapter 8: Asthma: Clinical expression and molecular mechanisms S95

Robert F. Lemanske, Jr, MD, and William W. Busse, MD, Madison, Wis

Chapter 9: Rhinitis and sinusitis S103

Mark S. Dykewicz, MD, and Daniel L. Hamilos, MD, Winston-Salem, NC, and Boston, Mass

Ó 2010 American Academy of Allergy, Asthma & Immunology

All rights reserved. No part of this publication may be reproduced, stored, or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any
information storage and retrieval system, without permission in writing from the publisher. Statements and opinions expressed in the articles and communications herein are those of the
author(s) and not necessarily those of the Editor, publisher, or the American Academy of Allergy, Asthma & Immunology. The Editor, publisher, and the American Academy of Allergy,
Asthma & Immunology disclaim any responsibility or liability for such material and do not guarantee, warrant, or endorse any product or service advertised in this publication nor do
they guarantee any claim made by the manufacturer of such product or service.

2A February 2010 J ALLERGY CLIN IMMUNOL

 CONTENTS
CONTINUED

Chapter 10: Food allergy S116

Scott H. Sicherer, MD, and Hugh A. Sampson, MD, New York, NY

Chapter 11: Drug allergy S126

David A. Khan, MD, and Roland Solensky, MD, Dallas, Tex, and Corvallis, Ore

Chapter 12: Allergic skin diseases S138

Luz S. Fonacier, MD, Stephen C. Dreskin, MD, PhD, and Donald Y. M. Leung, MD, PhD, Mineola, NY, and Aurora and Denver, Colo

Chapter 13: Environmental and occupational allergies S150

David Peden, MD, and Charles E. Reed, MD, Chapel Hill, NC, and Rochester, Minn

Chapter 14: Anaphylaxis S161

F. Estelle R. Simons, MD, FRCPC, Winnipeg, Manitoba, Canada

Chapter 15: Primary immunodeficiencies S182

Luigi D. Notarangelo, MD, Boston, Mass

Chapter 16: Secondary immunodeficiencies, including HIV infection S195

Javier Chinen, MD, PhD, and William T. Shearer, MD, PhD, Houston, Tex

Chapter 17: Immunologic rheumatic disorders S204

Amy Joseph, MD, Richard Brasington, MD, Leslie Kahl, MD, Prabha Ranganathan, MD, Tammy P. Cheng, MD, and John Atkinson, MD,
St Louis, Mo

Chapter 18: Vasculitis S216

Carol A. Langford, MD, MHS, Cleveland, Ohio

Chapter 19: Immunologic endocrine disorders S226

Aaron W. Michels, MD, and George S. Eisenbarth, MD, PhD, Aurora, Colo

Chapter 20: Diagnostic testing and interpretation of tests for autoimmunity S238
Christine Castro, DO, and Mark Gourley, MD, Bethesda, Md

Chapter 21: Pulmonary disorders, including vocal cord dysfunction S248

Paul A. Greenberger, MD, and Leslie C. Grammer, MD, Chicago, Ill

Chapter 22: Mucosal immunology, eosinophilic esophagitis, and other intestinal

inflammatory diseases S255
Dan Atkins, MD, and Glenn T. Furuta, MD, Denver and Aurora, Colo

Chapter 23: Complement disorders and hereditary angioedema S262

Michael M. Frank, MD, Durham, NC

Chapter 24: Immune responses to malignancies S272

Theresa L. Whiteside, PhD, ABMLI, Pittsburgh, Pa

Chapter 25: Clinical laboratory assessment of immediate-type hypersensitivity S284

Robert G. Hamilton, PhD, Baltimore, Md

J ALLERGY CLIN IMMUNOL February 2010 3A

 CONTENTS
CONTINUED

Chapter 26: Laboratory evaluation of primary immunodeficiencies S297

Joa˜o B. Oliveira, MD, PhD, and Thomas A. Fleisher, MD, Bethesda, Md

Chapter 27: Allergen immunotherapy S306

Anthony J. Frew, MD, FRCP, Brighton, United Kingdom

Chapter 28: Immunomodulator therapy: Monoclonal antibodies, fusion proteins,

cytokines, and immunoglobulins S314
Susan J. Lee, MD, Javier Chinen, MD, PhD, and Arthur Kavanaugh, MD, San Diego, Calif, and Houston, Tex

Chapter 29: Transplantation immunology: Solid organ and bone marrow S324
Javier Chinen, MD, PhD, and Rebecca H. Buckley, MD, Houston, Tex, and Durham, NC

Chapter 30: Embryonic and adult stem cell therapy S336

Anne C. Brignier, MD, and Alan M. Gewirtz, MD, Philadelphia, Pa

Study questions S345

Author Index S375
Subject Index S376
Answers to Study questions S381

4A February 2010 J ALLERGY CLIN IMMUNOL