PATHOPHYSIOLOGY

(BOOK BASED)
NON-MODIFIABLE MODIFIABLE

 Genetic Increase delivery of fatty  Obesity and dietary

predisposition acid habits
(Hypertension and  Obesity
DM)  Have high blood
 Female gender Absorption of fatty acid to pressure
 Hispanic ethnicity adipose tissue  Prolonged and heavy
 Hepatitis C alcohol consumption
 Age 40 years old  Cigarette smoking
above Fatty acids transported into hepatocytes


Accumulation of Fats in cells

Enlargement of the liver Decreased Decreased Decreased Decreased

liver cell conversion of synthesis of conversion of
ammonia into urea clotting factor bilirubin to
Increased pressure for excretion conjugated
exerted on the abdomen Decreased bilirubin
plasma albumin Blood in vomit
production Accumulation of and stools
RUQ pain ammonia in CNS Decreased
bilirubin
Decreased Bleeding and excretion
Nausea and vomiting intravascular bruising more
Trouble sleeping easily
oncotic pressure
(insomnia) Jaundice

Loss of appetite Third space fluid

shift

Weakness
Fluid retention

Muscle wasting