Analytical & Measuring

Instruments
Pocket Reference
 SHIMADZU
SCIENTIFIC INSTRUMENTS & EQUIPMENT

Introducing powerful performance

for the world

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 Quality recognized worldwide

Shimadzu Corporation is committed to helping scientists like you

do your job better. Founded in 1875, Shimadzu has a distinguished

history of innovation built on the foundation of contributing to

society through science and technology. This history is rivaled only

by the passion we have for the future as we continue to introduce

new solutions, faster than ever, for R&D and quality control in

such markets as pharmaceuticals, food products, semiconductors,

automotive, clinical, mining and metals, petrochemical, life sciences,

and environmental. In this ever-changing global landscape of industry,

Shimadzu will help you succeed by providing you “total solutions”

with the products and services you need.

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 Introducing our new products

LCMS-8060

MALDI-7090 RF-6000

HMV-G GCMS-QP2020

i-Series ICPMS-2030
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Pocket Reference
Contents

6 Chromatographs

18 Delivering New Technology

for Life Science

26 Spectroscopy Products

32 X-Ray Spectroscopic/
Surface Analysis Apparatus

35 Laboratory and On-line Total

Organic Carbon (TOC) and
Nutrient Analyzers

38 Testing Instruments for

Physical Properties

45 UniBloc Family of Balances

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 Chromatographs
Chromatography is the standard analytical separation technology
used for quantitative analysis. Ever since Shimadzu developed its
first gas chromatograph in 1956, we have continued to broaden our
chromatography lineup, by providing liquid chromatographs and
systems combined with mass spectrometers. Meanwhile, we have
developed a variety of application-specific systems designed for
customers in a wide range of industries, including pharmaceutical,
environmental, food and beverage, and petrochemical.
Shimadzu also provides data processing and data management
software to actively help customers comply with various regulatory
requirements, including GxP and FDA 21 CFR Part 11.

UHPLC HPLC/UFLC LC-MS/MS LC-MS

GC GC-MS/MS GC-MS
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Ultra High Performance
Liquid Chromatograph (UHPLC)
Shimadzu’s Nexera systems deliver superior, real-world performance across a wider
application range while delivering unparalleled flexibility and reliability in HPLC/UHPLC
analyses. The primary system, Nexera X2, is optimized to enable analysis at pressures
up to 19,000 psi without compromising performance and data quality. The modular
design of the Nexera series enables users to build application-specific systems. These
include the high-resolution Nexera SR, which is equipped with the SPD-M30A PDA
detector; a method scouting system capable of automatically investigating up to 96
combinations of mobile phases and columns; and Nexera-e, a comprehensive 2D LC.

New this year is the Nexera UC (Unified Chromatography), the world’s first fully
automated system that combines on-line SFE and SFC in a single flow path. This
unique system enables automatic extraction of up to 48 samples followed by seamless
transfer to SFC/MS for high-sensitivity detection of targets by mass spectrometry.

Products
• Nexera X2 • Nexera SR • Nexera UC (SFE-SFC)
• Nexera XR • Nexera MP • Nexera-e
• Nexera Method Scouting • Nexera Quaternary

Nexera UC
Applications
Pharmaceuticals
Food & Beverage
Chemical
Environmental
Biotechnology

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 Nexera MP Front-end UHPLC
The Nexera MP Ultra High Performance Liquid Chromatograph is the ideal front-end
system for all LC/MS platforms. It utilizes the SIL-30ACMP Multiplate Autosampler,
which features high-speed injection (7 seconds) to significantly improve throughput
in multi-sample processing, trace quantity injection repeatability values, and near-
zero carryover (0.0015% or less). To meet throughput demands, up to 6 microtiter
plates can be loaded, enabling a maximum of 2,304 samples to be analyzed
continuously.

A system for high-speed, high-accuracy analysis of multiple analytes can be

constructed by combining the Nexera MP with an ultra-high-performance mass
spectrometer, such as the triple quadrupole LCMS-8030/8040/8050/8060, or the
single quadrupole LCMS-2020.

Products
• Nexera MP

Nexera MP
Applications
Pharmaceuticals
Food & Beverage
Environmental
Biotechnology

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High Performance
Liquid Chromatograph (HPLC)
HPLC systems are able to quantitatively analyze substances in mixtures containing
multiple ingredients by separating and detecting target substances. They are also
able to purify specific substances once they are separated. The Prominence is a
modular HPLC system, which can be configured to create the optimal system
for specific customer applications, while the i-Series LC-2030 and LC-2040 are
completely integrated HPLC systems designed for innovative, intuitive, and
intelligent operation. Shimadzu also offers a wide variety of other application-
specific systems, such as automated sample pretreatment systems for separating
metabolites contained in pharmaceuticals or biological samples, residual pesticide
sample pretreatment systems for separating pesticides, and systems for analyzing
organic acids and amino acids.

Products
• Prominence (Modular HPLC) • Prominence nano (Nano-flow LC)
• i-Series (Integrated HPLC) • 2D Micro-HPLC System

i-Series
Applications
Pharmaceuticals
Food & Beverage
Environmental
Biotechnology

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 LabSolutions
Chromatography Software
Faster, more efficient management of LC/GC and LC/MS instruments and data
is essential. To address such requirements, Shimadzu offers a scalable range of
LabSolutions software packages, which feature an innovative operating environment
and provide complete data management to ensure secure information. All setup
and quantitative functions can be performed on one screen and wizards lead the
user through the process. It allows customized applications under software control
and provides universal reports for QA/QC verification and GLP/GMP compliance
automatically. The system administration includes user administration, system policy
setting, log browser, and audit trails, which support 21 CFR Part 11 compliance.

From LabSolutions Lite, offering control of one system, and LabSolutions LC/GC and DB,
enabling any combination of four LC/GC systems to be connected for simultaneous use,
to the networked LabSolutions C/S, Shimadzu can provide a solution for any laboratory
environment.
* Capabilities vary according to the platform

Products
• LabSolutions Lite • LabSolutions DB (Database)
• LabSolutions LC/GC • LabSolutions C/S (Client/Server)

LabSolutions
Applications
Pharmaceuticals
Food & Beverage
Environmental
Biotechnology

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Triple Quadrupole
Mass Spectrometer
The newest model in the Ultra-Fast Mass Spectrometry series, the LCMS-8060
incorporates Shimadzu’s proprietary ultrafast technologies (UF Technologies) to enable
a polarity switching time of 5 msec, a data acquisition scan speed of 30,000 u/sec, and
ultra-fast MRM measurements up to 555 ch/sec. A redesigned UF-Qarray ion optical
system offers outstanding ion sampling efficiency and ion focusing. Combined with a
robust design and easy maintenance, the LCMS-8060 is the ideal solution for better data
quality and higher throughput for a wide array of challenging and routine applications.

Other models include the LCMS-8050, which provides both best-in-class sensitivity and
excellent quantitation performance; the LCMS-8040, which offers enhanced sensitivity
for complex matrices and difficult analytes; and the rugged LCMS-8030, built for routine
quantitative analysis in challenging matrices. Combine any system with Shimadzu’s
world-leading UHPLC systems for an unmatched level of performance.

Products
• LCMS-8060 • LCMS-8050
• LCMS-8040 • LCMS-8030

LCMS-8060
Applications
Environmental
Pharmaceuticals
Food & Beverage
Clinical
Chemical

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 Single Quadrupole
Liquid Chromatograph-
Mass Spectrometer
Building an LC/MS system that employs an MS as an LC detector can effectively
reduce the limitations of LC analysis. The qualification performance of
spectrometers is useful for detecting impurities in overlapped peaks.
Utilizing patented ultrafast (UF) technology, Shimadzu’s LCMS-2020 mass
spectrometer offers faster measurements and higher detection sensitivity for
quicker and more accurate detection of trace impurities in a variety of applications.
It features an ultrafast scanning speed of 15,000 u/sec, without sacrificing
sensitivity or resolution, unsurpassed 15 msec polarity switching speed, for the
most data without peak deterioration in a single injection, and multiple Ionization
options (ESI, APCI, and DUIS). Innovative ion optics provides greater sensitivity
than any other single quadrupole analyzer, while easy system maintenance enables
greater uptime and usability.

Products
• LCMS-2020 (ESI standard)
• DUIS-2020 (Optional ionization, simultaneous ESI and APCI ionization)
• APCI-2020 (Optional ion source)

LCMS-2020
Applications
Pharmaceuticals
Food & Beverage
Environmental
Biotechnology

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Hybrid High Performance
Liquid Chromatograph-
Mass Spectrometer
The LCMS-IT-TOF is a system which combines an ion-trap mass spectrometer (IT)
with a time-of-flight mass spectrometer (TOF). The ion trap offers MSn capability
and the TOF provides high-resolution and highly accurate MS analysis capability.
This combination offers the diverse analysis information required for effective
structure analysis in such research areas as impurity analysis, metabolomics profiling
and biomarker discovery. In addition, Shimadzu offers user-friendly, application-
specific software products to maximize the performance of the LCMS-IT-TOF.

Products
• LCMS-IT-TOF
• APCI Source (Optional)
• Software Packages: Formula Predictor, Profiler, MetID Solution

LCMS-IT-TOF
Applications
Metabolomics
Protein
Food & Beverage
Natural Products

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 Gas Chromatograph
The GC-2010 Plus enables reliable trace analysis utilizing detectors such as FID
and FPD that feature best-in-class sensitivity. Newly introduced Advanced Flow
Technology reduces analysis times, provides enhanced chromatographic resolution,
and enables application-specific configurations, such as multidimensional GC,
backflush, and detector splitting and switching systems, without compromising
performance. The GC-2014 can be used for both capillary and packed column
analysis. Integrating the new barrier discharge ionization detector (BID-2010 Plus), a
novel universal detector that incorporates plasma technology, Tracera GC makes it
possible to reveal trace components not easily detected by other devices.

Products
• GC-2010 Plus (Capillary GC)
• GC-2014 (Capillary/Packed GC)
• GC-8A (Simple GC)
• Tracera
• Advanced Flow Technology Devices (Multidimensional GC/Heart-cut/
Backflushing/Detector Splitting/Detector Switching)

GC-2010 Plus
Applications
Petrochemical
Environmental
Flavor & Fragrance
Biofuels

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System GC Program
The updated System GC program provides customers with application-specific
GCs that offer a complete solution for a laboratory’s specific needs. The modular
GC-2014 is the workhorse of the system GC program. It features the ability to hold
4 detectors, 12 channels of Advanced Pressure Control, 16 time programmable
relays, and a large oven that can accommodate many columns. Each system is
customized with a GC, valves, an inert treatment for the analytical flow path, and
installation and start-up supplies. In addition, each system is shipped with proof of
performance, QA/QC, and a field test standard.

Products
• System GC

System GC
Applications
Natural Gas
Transformer Gas
Greenhouse Gas
Biofuels
Biomass Feedstock Research

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 Triple Quadrupole
Gas Chromatograph
Mass Spectrometer
Featuring Smart Productivity, Smart Operation, and Smart Performance, the GCMS-
TQ8040 is the most accurate, cost-effective and user-friendly GC-MS/MS available. The
system enables analysis of 400+ compounds in a single MRM run without sacrificing
sensitivity or selectivity while the MRM Optimization Tool seamlessly selects and
optimizes MRM transitions for multiple compounds in a single sequence. Other features
include high-speed MRM analysis of up to 800 transitions per second, high-speed
scanning control at 20,000 u/second, Scan/MRM analysis mode, Automatic Adjustment
of Retention Times (AART), and quick, stress-free maintenance.

The GCMS Smart Database Series is comprised of separate databases for analyzing
pesticides, forensic toxicological substances, metabolites and environmental pollutants.
Each database includes hundreds of related compounds with optimized transitions and
collision energies, CAS registry numbers and retention indices (RI). The software series
supports simultaneous high-sensitivity analysis of samples using GC-MS/MS, eliminating
the need to configure complicated analysis conditions.
Products
• GCMS-TQ8040

GCMS-TQ8040
Applications
Food Testing
Environmental
Life Science
Forensics/Toxicology

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Gas Chromatograph-
Mass Spectrometer (GCMS)
Shimadzu’s quadrupole GCMS systems contribute to increased sensitivity and higher
productivity in the laboratory. A newly-designed electric control platform provides
best-in-class scanning speed and the advanced scanning speed protocol (ASSP) ensures
sensitivity improvement at high-speed data scanning. Features for shorter analysis time
and easy maintenance increase efficiency. Library search using Linear Retention Indices
and Automatic Adjustment of Retention Times (AART) make identification easy and
reliable. In addition to standard models with electron ionization (EI), Shimadzu also
offers models with Chemical Ionization (positive and negative) for enhanced selectivity
as well as sensitivity. Options/accessories include a direct sample introduction system,
multiple autosamplers, a cooled PTV (temperature programmable injector) (OPTIC-4),
a Pyrolyzer (Py-3030) and Shimadzu Advanced Flow Technologies for Heart-Cut GC/
GCMS. Shimadzu’s fast quadrupole with up to 100 scans/s enables the system to
perform Comprehensive GCMS, using thermal modulation (Zoex loop modulator) for
narrowest peak shape and highest sensitivity.

Products
• NEW GCMS-QP2020, available models: EI, EI/CI, EI/CI/NCI (upgradable)
• GCMS-QP2010 SE (Standard EI)
• Twin Line GCMS

NEW GCMS-QP2020
Applications
Environmental
Flavor & Fragrance
Petroleum Industry
Forensics
RoHS/WEEE/ELV

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 Delivering New Technology
for Life Science
Shimadzu is focused on developing new tools by integrating novel
chemistry with innovative technology to help accelerate life
science research.

Whether it is an experiment for protein expression, characterizing

differences in metabolism studies, or imaging tissue with mass
spectrometry, Shimadzu can help you discover more about your
biological samples.

TOF-MS Processors UV Sequencers

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MALDI-TOF Mass Spectrometry
Offering unparalleled MS/MS resolution and excellent mass accuracy, Shimadzu’s
high-throughput, high-energy, high-resolution MALDI-7090 tandem mass spectrometer
achieves a new level of MALDI-TOF MS performance. It combines Shimadzu’s extensive
MALDI TOF-TOF expertise with novel patented technology to provide ultimate
performance in identification and structural characterization of biomolecules. It features
2 kHz acquisitions in all modes, a high-resolution ion gate, low and high-energy
fragmentation, a 10 plate sample loader, and a multi-user software environment.
The AXIMA Assurance linear MS is ideal for high-throughput QA/QC environments and
simple, yet accurate mass measurements. A linear/reflectron MS, the AXIMA Confidence
incorporates the patented curved field reflectron (CFR) for flexibility and reliable, simple
MS/MS. The AXIMA Performance is a TOF2 MS featuring high-energy CID and excellent
sensitivity. The only commercial MALDI-QIT-TOF MS, the AXIMA Resonance combines
the MSn capabilities of an ion trap and the high mass accuracy abilities of time-of-flight.

Products
• MALDI-7090 (TOF-TOF)
• AXIMA Assurance™ (Linear MALDI MS)
• AXIMA Confidence™ (Linear/Reflectron MALDI MS)
• AXIMA Performance™ (TOF-TOF)
• AXIMA Resonance™ (MALDI QIT-TOF)

MALDI-7090
Applications
Proteome Analysis
Polymer Analysis
Structural Analysis
Identification of Microorganisms
QA/QC Analysis
Biomarker Discovery
Structural Analysis of Glycans
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 Megadalton MALDI
Mass Spectrometer
The solution for ultrahigh mass applications, the MegaTOF has been developed by
optimizing the integration of a high-performance Shimadzu linear MALDI-TOF mass
spectrometer with a CovalX high-mass system, allowing outstanding detection of
macromolecules up to 1,500 kDa. Ideally suited for such applications as antibody
characterization, protein complexes characterization, therapeutic protein aggregates and
high mass MALDI imaging, features include:

• Ultrahigh sensitivity
• Detects macromolecules up to 1,500,000 Da
• Stabilization of molecule using crosslinking reagent kits
• Fast, specific stabilization of protein interactions
• Also applicable for low mass applications
• Apple® iPod touch control

Products
• MegaTOF

MegaTOF™
Applications
Antibody Characterization
Protein Complexes Characterization
Therapeutic Protein Aggregates
High Mass MALDI Imaging
Inhibitors of Protein-protein
Interactions

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Functional Near-Infrared
Spectroscopy (fNIRS) Systems
Shimadzu’s LABNIRS, a product that can use human thought to control a robot or to
improve our understanding of childhood development or human interaction, is the
most comprehensive fNIRS system available to neuroscientists today. It uses fNIRS to
measure brain activity based on blood oxygenation levels. LIGHTNIRS enables portable
fNIRS measurements by remaining compact enough to fit inside of a backpack while still
providing high-quality blood oxygenation level signals of the cerebral cortex.

• Systems configured with up to 142 channels (40 fiber sets) to provide researchers
whole head coverage with high resolution
• Advanced semiconductor laser technology and photomultipliers to enhance signal
quality and sensitivity
• Flexible fiber placements
• Range of flexible adjustable surface holders (FLASH) to provide seamless mapping of
the entire brain
• Analog and digital input/output connections for multimodal NIRS imaging
• Intuitive system interface
Products
• NEW LABNIRS fNIRS System for Brain Imaging Research
• NEW LIGHTNIRS fNIRS System for Brain Imaging Research

NEW LABNIRS
Applications
Medical Research
Cognition
Development
Rehabilitation
Brain Machine Interface

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 Automated Protein
Sample Prep
The Perfinity Workstation is a fully-integrated online mass spec sample preparation
workstation, combining the selectivity of immunoassay approaches with the resolution
of high performance liquid chromatography. It utilizes multiple proteomic approaches to
rapidly and reproducibly perform affinity selection, buffer exchange, trypsin digestion,
desalting of the sample and reverse phase LC analysis.

The Perfinity Integrated Digestion Platform (iDP) is a simplified platform automating the
same proteomics workflow steps except for affinity selection. Perfinity IDP dramatically
reduces sample prep times while providing consistent, highly reproducible results.

• Serum to purified peptides in < 10 min.

• Three-day workflow complete in under one hour
• High-quality, reproducible proteolysis data (CVs < 10%)
• Hands free operation–fully automated
• Significant reduction in cost per sample
• Easily customizable

Products
• Perfinity Workstation
• Perfinity iDP

Perfinity Workstation
Applications
Assay Development
Drug Development
Protein Purification
Biomarker Screening

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TOF MS Apparatus
(iMLayer/AccuSpot)
Used in conjunction with Shimadzu’s MALDI-TOF mass spectrometers, the iMLayer
provides a precise method for obtaining high spatial resolution imaging mass
spectrometry. It uses vaporization to deposit matrix to tissue slices using what is
called the “dry coat” method. In this method, matrix powder is heated under vacuum
to the boiling point of the matrix crystals. The sample positioned above the matrix
then becomes coated with a thin layer of matrix with submicron crystal sizes. A laser
positioned above the sample is utilized to control the thickness of the matrix layer,
resulting in reproducible matrix deposition.

The AccuSpot™ is a high-capacity LC spotting robot specifically designed for MS analysis

which supports collection of up to 9 Shimadzu MALDI micro-filter plate format targets
as well as ABI and Bruker formats. The AccuSpot uses a “half-contact” spotting method
to prevent damage to the plate or probe tip.

Products
• iMLayer (Matrix vapor deposition system )
• AccuSpot™ (High-capacity LC spotting system)

iMLayer AccuSpot
Applications Applications
MS Tissue Imaging High-Throughput LC-MALDI Analysis

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 Micro-volume
Spectrophotometer
Shimadzu’s micro-volume BioSpec-nano is a low-maintenance micro-volume
spectrophotometer designed for the modern life science laboratory. Its easy-to-use
design and superior detection limits, up to 10 times better compared to the competition,
make it the perfect instrument for quantitation of DNA, RNA, protein analysis, and
photometric measurements.

• Ultra-small sample volumes (1 µL to 2 µL samples)

• Easy operation with “Drop-and-Click” analysis
• Rapid analysis times — Easy sample mounting and automated cleaning enable
a rapid 3-second analysis time and a 10-second cycle time between samples
• Optional 5mm pathlength cell
• Photometric analysis (up to 8 wavelengths)
• Dedicated software allows ease of quantitation of DS/SS DNA and
labeled/unlabeled proteins

Products
• BioSpec-nano

BioSpec-nano
Applications
Quantitation Analysis for
DNA and RNA Nucleic Acid
Photometric Measurement
Protein Analysis

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Automated Protein Peptide
Sequencer
PPSQ-51A/53A systems use Edman degradation to cleave amino acids, one at a
time, from the N-terminals of proteins, then derivatize them to PTH amino acids and
determine the sequence of amino acids using HPLC. PPSQ-51A/53A systems are useful
for obtaining a conclusive N-terminal sequence from proteins. Protein sequencing
with the PPSQ-51A/53A has found utility in applications such as protein therapeutics
QC, animal toxin analysis, characterization of artificially synthesized proteins, and
identification of proteins from organisms with no existing database.

The new PPSQ sequencers utilize the SPD-M30A PDA detector, which features a high-
sensitivity capillary cell that has an 85 mm optical path length that is 8.5 times longer
than a standard cell. This helps analyze lower concentration samples or to analyze
longer sequences. In addition, LabSolutions PPSQ software enables FDA 21 CFR Part 11
compliance with regard to security, user management, and audit trail requirements.

Products
• NEW PPSQ-51A/53A (Protein sequencing)

NEW PPSQ-51A/53A
Applications
Protein Sequencing via Automated
Edman Degradation Chemistry

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 Spectroscopy Products
Spectroscopy is a general term for analytical methods utilizing ultraviolet
(UV), visible (VIS), infrared (IR), or near infrared (NIR) light to analyze
substances. Major types include absorption spectroscopy, where the
absorption of specific wavelengths resulting from different molecular
structures is measured, atomic absorption spectroscopy, where substances
are first atomized, then the absorption of the atomic vapor is measured,
fluorescence spectroscopy, where a specific wavelength is absorbed and
then the emission of a different wavelength is measured, and inductively
coupled plasma atomic emission spectroscopy (ICP-AES), where substances
are subjected to high-temperature excitation and characteristic light
emissions from elements are measured. Instruments measuring absorption,
atomic absorption or fluorescence are comprised primarily of light sources,
monochromators and detectors. In emission spectrometers, the sample is
introduced into the light source. Shimadzu’s product line includes UV-VIS-
NIR spectrophotometers, Fourier transform infrared spectrophotometers,
atomic absorption spectrophotometers, and ICP spectrometers.

UV FTIR AA

Spectrofluorophotometer ICP
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UV-Vis Spectrophotometer
Shimadzu has been manufacturing UV-Vis spectrophotometers for more than 60 years,
and excels at providing instruments that meet scientists’ needs for ruggedness, ease of
use, validation and applications. This flexibility enables spectroscopists in virtually any
laboratory, from pharmaceutical, materials science, and environmental to academic
research, food & beverages, and life sciences, to select the instrument best suited to
their application. Options include the monitored single-beam UV-1280 for routine
laboratory analyses; robust, high-resolution UV-1800; single and double monochromator
UV-2600/2700, which feature a wealth of accessories/software packages to address
routine analyses as well as demanding research applications; and the three-detector UV-
3600 Plus/SolidSpec-3700 UV-Vis-NIR systems, which provide the utmost in sensitivity
and resolution across the entire wavelength range.

Products
• UV-3600 Plus/SolidSpec-3700 (UV-VIS-NIR spectrophotometers)
• UV-2600/2700 (UV-VIS spectrophotometers with variable bandwidth)
• UV-1800 (Multi-purpose spectrophotometer)
• UV-1280 (Standalone spectrophotometer with bio functions)

UV-3600 Plus
Applications
Pharmaceuticals
Biotechnology
Water Quality
Nanotechnology
Solar Cells

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 FTIR Spectrophotometer
Fourier transform infrared (FTIR) spectrophotometers are primarily used to predict
(qualitate) the structure of organic compounds. When molecules are irradiated with
infrared light, the infrared wavelengths corresponding to the vibrational energy between
the constituent atoms are absorbed. Infrared spectroscopy evaluates the degree of this
absorption to quantify or predict the structure of compounds.

Combining high speed (up to 20 spectra/sec acquisitions), best-in-class 60,000:1 S/N

ratio, and excellent resolution (0.25cm−1) with enhanced expandability and easy-to-
use software, the IRTracer-100 quickly and easily obtains high-quality data for a wide
range of samples. It features a stable, airtight interferometer that incorporates a built-in
automatic dehumidifier, while the patented Advanced Dynamic Alignment provides
enhanced stability and shorter warm-up times. Designed with the teaching and general
research laboratories in mind, the IRAffinity-1S offers full functionality for all FTIR
techniques in a compact design.

Products
• IRTracer-100
• IRAffinity-1S

IRTracer-100
Applications
Pharmaceuticals
Organic Chemistry
Polymers
Environmental
RoHS / WEEE / ELV
Nanotechnology
Solar Cells
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Spectrofluorophotometer
Compared to absorption methods, fluorescence spectroscopy is ten to several thousand
times more sensitive. This allows analyzing picogram to nanogram-sized samples
with excellent results. Fluorescence can also be used to identify specific molecules in
a complex spectral background. This technique is widely used in pharmaceuticals and
pharmacology, biochemistry, food science, environmental monitoring and chemical
analyses.

Incorporating intuitive LabSolutions RF software, and featuring a wealth of accessories,

the RF-6000 delivers the ultimate in performance for a range of applications. It
features the highest sensitivity and highest signal-to-noise ratio (SNR) in its class (SNR
≥1,000 RMS and ≥350 peak-peak); high-speed 3D scanning of 60,000 nm/min; and
an extended upper wavelength range to 900nm. The Xenon lamp features a 2,000
hour service life and auto alignment technology for less frequent and more user-
friendly maintenance. LabSolutions RF software features sophisticated, yet easy-to-use
functionality ranging from standard fluorescence to 3D measurements of fluorescence
spectra at any wavelength interval.

Products
• RF-6000 Spectrofluorophotometer

RF-6000
Applications
Biotechnology
Environmental
Clinical
Pharmaceuticals

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 Atomic Absorption
Spectrophotometer
Since introducing its first atomic absorption spectrophotometer in 1968, Shimadzu has
continued to lead the field of inorganic compound analysis. Shimadzu now offers the
AA-7000. This flexible system provides users with best-in-class sensitivity, and can be
customized into a low-cost single-purpose model and a fully automatic general-purpose
system. The AA-7000 also employs various safety features, and it is the world’s first AA
spectrophotometer that employs an automatic quench function, which works in case
of detection of an earthquake. The WizAArd workstation software is also improved and
can be linked to CLASS-Public Agent software to provide compliance with FDA 21 CFR
Part 11.

Products
• AA-7000F (Flame type)
• AA-7000G (Furnace type)
• AA-7000F + GFA-7000 (Optional/ Flame and furnace type)
• AA-6200 (Affordable AAS)

AA-7000
Applications
Environmental
Agriculture & Food
Water Quality
RoHS/WEEE/ELV

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Inductively Coupled Plasma
Mass Spectrometer & Atomic
Emission Spectrometer
The newly developed ICPMS-2030 is designed on two fundamental concepts: make it
the easiest system to operate with the lowest possible operating cost. The industry’s
first Assistant software functions include a Development Assistant and a Diagnosis
Assistant. This function allows anyone to obtain reliable results quickly by automatically
checking for any spectral interference based on all element and mass data, and provides
information on how to resolve issues if they arise.

A mini-torch lowers gas consumption while additional cost savings are achieved
due to the system’s compatibility with lower purity Argon, 99.95% pure. The newly
developed collision cell achieves high molecular ion elimination and high transmission
efficiency. It can perform all measurements with only helium cell gas. Furthermore, it can
measure all elements without discharging the cell gas, which enables rapid and reliable
measurement of all elements simultaneously.

Products
• NEW ICPMS-2030
• ICPE-9800 series

NEW ICPMS-2030
Applications
Environmental
Petroleum Industry
Metals
Semiconductors
RoHS/WEEE/ELV
Solar Cells

31
 X-Ray Spectroscopic /
Surface Analysis Apparatus
X-ray spectroscopic/surface analysis apparatus utilize X-rays or electron
beams to measure and analyze constituent elements. This product category
includes EDX, XRF and MXF systems, which detect X-ray fluorescence to
identify the type of elements contained in samples (qualitative analysis)
and measure the concentration of each (quantitative analysis), and
XRD systems, which analyze the diffraction of X-rays to learn about the
crystalline structure of samples.

In particular, Shimadzu’s EDX systems provide an easy way to measure

the six substances (five elements) regulated by the RoHS/ELV directives in
Europe. As a result, Shimadzu has gained extensive experience providing
EDX systems to customers for the screening of electrical/electronic parts
or automotive parts to determine to what degree they contain these
regulated substances.

XRD EDX, XRF, MXF

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X-ray Diffractometer
When a sample is irradiated with X-rays, a variety of signal types can be obtained.
Of those signals, X-ray diffraction reveals the crystalline state of samples. Analyzing
these diffracted X-rays allows learning about the crystalline structure of samples.
XRD series spectrometers are powder X-ray diffractometers used primarily to
identify constituents of powder (multi-crystalline) samples (qualitative analysis) and
determine their concentration (quantitative analysis). For example, they can be used
to precisely determine the lattice constant, crystallite size, lattice distortion or degree
of crystallization of released silicic acid or asbestos by qualitatively and quantitatively
analyzing the samples and also numerically analyzing their diffraction X-ray profile.
Furthermore, numerous optional products are available to allow other analytical
applications such as observing changes in crystalline structure as temperature varies or
measuring residual stresses.

Products
• XRD-6100
(Vertical goniometer type varying x-ray angle of incidence and angle of diffraction)
• XRD-7000
(Horizontal goniometer type for measuring soluble or loose powder samples,
electronic materials, stress distributions in large automotive or other samples, and
many other applications)

XRD-7000
Applications
Ferrous & Non-Ferrous Metals
Pharmaceuticals
Polymers & Materials
Semiconductors
Solar Cells

33
 X-ray Fluorescence Specrometer
X-ray fluorescence spectrometers irradiate samples with X-rays and measure the
characteristic wavelengths or energy in the secondary X-rays (X-ray fluorescence)
generated from the sample. They are able to identify the type of constituent elements
in samples (qualitative analysis) and measure the concentration of each (quantitative
analysis). Since samples can be analyzed non-destructively and without contacting the
sample, X-ray fluorescence spectrometers can be used for a wide range of applications,
regardless of whether the sample is a solid, liquid, powder or other form. Shimadzu
offers two types of X-ray fluorescence spectrometers – wavelength dispersive systems,
which provide outstanding detection of trace substances, and energy dispersive systems,
which are compact and able to analyze samples easily and rapidly.

Products
• Energy Dispersive X-Ray Fluorescence Spectrometers
EDX-7000/8000
EDX-LE (Designed for WEEE, RoHS, and ELV applications)
• Wavelength Dispersive X-Ray Fluorescence Spectrometers
XRF-1800 (Top-of-the-line all-in-one type sequential analyzer)

EDX-7000/8000
Applications
Ferrous & Non-Ferrous Metals
Petroleum
Agriculture & Food
Semiconductors
RoHS/WEEE/ELV
Nanotechnology
Solar Cells
34
 Laboratory and On-line Total
Organic Carbon (TOC) and
Nutrient Analyzers
Shimadzu is the world leader in the manufacture of TOC analyzers. Our
state-of-the-art instruments maximize sensitivity, oxidation efficiency, and
productivity, making them your ideal choice for monitoring environmental
samples or pharmaceutical cleaning validations. Addition of a nitrogen
module enables rapid, safe, and cost-effective analysis for organic and
total nitrogen. Add an optional solid sample module to determine organic
and inorganic carbon in soil and filter media. Our highly advanced on-line
TOC and total nitrogen/total phosphorus analyzers provide real-time TOC
removal for drinking water treatment, process monitoring of BOD and
nitrogen / phosphorus removal in wastewater treatment, or continuous
monitoring of organic carbon, nitrogen, and phosphorus loading in
ambient water.

TOC On-line TOC

On-line Total
Total Organic Carbon Nitrogen/Phosphorus

35
 Total Organic Carbon Analyzer
Total organic carbon (TOC) analyzers measure the total amount of organic matter
contained in water. They are used for a wide range of applications, from environmental
analysis, water treatment management, and various processing control applications, to
evaluating the effectiveness of cleaning or the amount of organic eluting material in
water. TOC analyzers are available as either laboratory models or on-line analysis models.
Laboratory TOC analyzers offer a wide assortment of options for analyzing everything
from ultra-pure water to contaminated water and solid samples to gas samples.
Shimadzu offers models based either on the 680°C combustion catalytic oxidation
method, developed by Shimadzu and subsequently spread around the world, or the
wet oxidation method. With an ultra-wide measurement range (4 μg/L to 30,000 mg/L),
patented 680°C Combustion Catalytic Oxidation/NDIR detection method, and powerful
options/accessories, the TOC-L Series meets the TOC testing requirements in wide range
of applications.
Products
• Catalytic combustion oxidation TOC analyzer
• Wet chemical oxidation TOC analyzer
• Total nitrogen unit for TOC
• Solid sample combustion unit for TOC
• On-line TOC analyzer
• On-line total nitrogen/phosphorus analyzer

TOC-L Series
Applications
Environmental Water
Process Water
Ultra-Pure Water
Cleaning Validation
Pharmaceutical Water Management

36
On-Line TOC / TN Analyzer
On-line TOC analyzers are used for a wide variety of applications, from managing the
raw water for wastewater treatment, or managing the discharge or effluent water
after it has been treated, to monitoring the organic impurities in public water supplies,
cooling water, condensate water, or rinse water. The 4200/4110 Series Shimadzu On-
Line Water Quality Analyzers, with their proven combustion technology, lead the way in
on-line water quality analysis technology. The TOC-4200 features the proven, industry-
standard 680°C Combustion Catalytic Oxidation Method and a number of cost-reducing
features to support sensitive, efficient TOC analyses. Features include multi-functional
sample injector, high-salt sample combustion tube kit, and an on-board air purifier.

Products
• TOC-4200 (On-line TOC Analyzer)
• TOCN-4110 (On-line TOC/TN Analyzer)
• TN-4110 (On-line TN Analyzer)

TOC-4200
Applications
Management of Influent and Effluent Water
Monitoring of Boiler and Condensate Water
Management of Various Plant Water
Water Quality Monitoring for
Regulatory Reporting

37
 Testing Instruments for
Physical Properties
Shimadzu began production of its first material testing machine in 1917,
and has since continued to provide testing machines that are vital to
product development. Instruments include our Autograph high-precision
universal testing machines, Servopulser fatigue testing machines, hardness
testers and particle size analyzers. These products have undergone many
improvements and are now widely accepted as being equipped with
superior technology. Essentially, testing machines have been in existence
since the onset of manufacturing to assure the quality of production
metrics. Our efforts to satisfy the rigorous demands of customers
over the past 90+ years have earned us the reputation as the world’s
top manufacturer of testing machines. Shimadzu remains committed
to challenging ourselves to innovate and develop new evaluation
technologies to satisfy the increasing demands for safety and reliability.

Universal Testers Fatigue and Endurance Testers Hardness Testers

Particle Size Thermal High-Speed

38 Analyzers Analyzers Video Camera
Universal Tester
Tests to evaluate the strength of objects are conducted across a wide range of scales –
from fine particles and surface-mounted components in the nano-range to large steel
and concrete specimens. The forces applied to the test specimens by the tester also
cover a wide range from 2 mN to 2000 kN (or more). Various types of strength tests are
conducted, including tensile, compression, bending, crack, peeling, creep, and stress
relaxation testing. The Shimadzu Universal Tester lineup includes the AG-X plus series,
precision testers for the most demanding applications, featuring frame capacities up
to 300 kN (66,000 lbf) as standard; the AGS-X series, high-quality testers for routine
analysis and quality control; the EZ-X series compact, single-column testers ; and the
UH-X/FX hydraulic testers for high-force applications.

Products
• UH-X/FX Series (Hydraulic universal tester)
• AG-X plus Series (“Autograph” precision tester)
• AGS-X Series (Standard universal tester)
• EZ-X Series (Tabletop precision tester)

Autograph AG-X plus

Applications
Steel & Metals
Plastics & Rubber
Composites
Textiles

39
 Fatigue and Endurance
Testers
The evaluation of strength, which relates to safety and durability, will affect a product’s
life. It has become increasingly important in areas such as product development, quality
control and failure analysis. The Servopulser Series of high-performance, high-accuracy
strength testing machines can accommodate this diverse range of requirements.
The Microservo MMT Series offers high-frequency tests up to 100Hz. Featuring an
electromagnetic actuator with an exceedingly high frequency response for its loading
mechanism, combined with closed loop control, makes high speed and precise
measurements possible over micro loads and micro displacement.

Products
• Microservo (Magnetic micro fatigue tester MMT series)

MMT Series
Applications
Resin
Rubbers
Metals / Electronic Parts
Composites

40
Hardness and Surface
Evaluation Testers
The micro hardness tester is an instrument that is indispensable to metallographic
research, product quality control, and the research and development of new materials.
For this type of work, it is important to be able to measure the hardness of small parts
and metallic structures used in precision equipment, processed surface layers, metal
plating layers, etc. This type of measurement must be performed on a limited small area
with virtually no damage to the area being measured, and must yield extremely reliable
results.

Winner of an IBO 2013 Industrial Design Award, the operator-friendly HMV-G Series
of Micro Vickers hardness testers features a built-in CCD camera for automatic length
measurement, an automatic lens switching function, and a sample shape recognition
function. In addition, the innovative G-frame design dramatically improves operability
while permitting effective measurement of long and large test samples.

Products
• HMV-G Series (Micro Vickers hardness tester)
• DUH Series (Dynamic ultra micro hardness tester)
• MCT Series (Micro compression tester)

HMV-G Series
Applications
Steel & Metals
Heat Treatment
Ceramics
Electrical & Electronics
Solar Cells

41
 Powder & Particle Size Analyzer
From dense to superfine particles, Shimadzu has a high-performance particle size
analyzer for a variety of applications. Laser diffraction particle size analyzers measure
particle size distribution, a property which determines the behavior and characteristics
of powders. For instance, in pharmaceuticals, particle size can influence the drug’s
effectiveness or side effects. In the case of foods, particle size and the distribution can be
a major factor in determining “smoothness to the teeth” and “texture”. The SALD-2300
is able to analyze wet or dry samples across a wide particle concentration range of 0.1
ppm to 20% and provides continuous measurement in real time, at minimum one-
second intervals, for instantaneous analysis. In addition, it enables the measurement of
high-concentration samples without dilution, preventing dispersion or agglomeration.

Products
• SALD-201/301V (Laser Diffraction Particle Size Analyzer, 0.1 µm to 350 µm)
• SALD-2300 (Laser Diffraction Particle Size Analyzer, 17 nm to 2500 µm)
• SALD-7500nano (Laser Diffraction Particle Size Analyzer, 10 nm to 300 µm)
• IG-1000 Plus (Single Nano Particle Size Analyzer, 0.5 nm to 200 nm)

SALD-2300
Applications
Pharmaceuticals
Organic/Inorganic Chemistry
Metals
Polymers

42
Thermal Analyzer
Thermal analyzers measure the temperature dependence of the sample substance’s
physical properties by varying the temperature of samples. Shimadzu’s product line
includes DSC models, which measure the transition reaction in a sample when heated
or cooled, TGA models, which measure changes in mass, and TMA models, which
measure the deformation of substances when exposed to non-oscillating loads, such as
compression, tension, bending, and torsion. Featuring an integrated balance assembly,
the DTG-60 provides high sensitivity and excellent stability over a wide dynamic mass
range.

Products
• DSC-60 Plus (Differential Scanning Calorimeters)
• DTG-60/60H (Simultaneous TG/DTA)
• TMA-60/60H (Thermomechanical analyzers)
• Automatic TA (Auto DSC & Auto TG/DTA)
• TGA-50/50H, 51/51H (Thermogravimetric Analyzers)

DSC-60 Plus
Applications
Polymers
Pharmaceuticals
Petroleum Industry
Food Products
Metals
Ceramics

43
 High-Speed Video Camera
Shimadzu’s High-Speed Video Camera, the HyperVision HPV-X2, offers world-class ultra-
high-speed video recording of up to ten million frames per second. It is equipped with
a synchronized recording function while dedicated software allows recording to start
immediately after performing a few simple settings. Recorded images can be saved in
general image formats such as AVI or BMP. The HPV-X2 permits recording of ultra-high-
speed phenomena not previously possible in a wide variety of fields that require high-
speed image capture, such as materials failure, fluid dynamics and combustion.

The HPV-2, with a recording speed of up to 1 million frames per second, allows
multi-camera synchronized recording (up to 4 cameras), enabling the analysis of a
phenomenon in more detail.

Products
• NEW HPV-X2 (10,000,000 fps high-speed video camera)
• HPV-2 (1,000,000 fps high-speed video camera)

NEW HyperVision HPV-X2

Applications
High-Speed Objects
Fluid Dynamics
Electric Discharge
High-Speed Phenomena
at Micro-Scales

44
UniBloc Family of Balances
AUW-D Series Dual-range Semi-micro Balances
AUW-D dual-range semi-micro balances are the first five-decimal balances with the
advantages of UniBloc one-piece force cell technology.

AUW/AUX/AUY/ATX/ATY Series Analytical Balances

AUW/AUX/AUY models are the newest single-range analytical balances engineered with
the UniBloc technology. This provides especially fast response and superb stability.

UW/UX/TX/TXB Series Top-Loading Balances

These top-loading balances are engineered with the UniBloc mechanism, resulting in
unrivaled response, stability and durability. Powerful features support any imaginable
weighing application. The UW Series includes internal calibration and fully-automatic
calibration functions.

BW-K/BX-K Series Precision Platform Balances

The Shimadzu Precision Platform balances have been engineered with the innovative
UniBloc mechanism since 1989. Powerful features support any imaginable weighing
application. The BW-K Series includes internal calibration weight.

MOC63u/MOC-120H Electronic Moisture Balances

In many fields, a moisture analyzer is a necessary tool for quality control requirements.
With the MOC63u, you can easily obtain accurate data. Simply place material on the
pan and shut the cover. The MOC63u will start to measure. The MOC63u adapts to
various materials and increases your work efficiency.

45
 Clinical/
Product Index Toxicology/
by Market Page Automotive Chemicals Forensics Electronics

UHPLC/HPLC 7  

LC-MS/MS 11  

GC 14   

GC-MS/MS 16    

MALDI-TOF 19   

Bio-focused Products 22  

UV-Vis 27    

FTIR 28    

Fluorescence 29    

AA 30 

ICP 31    

XRD 33   

EDXRF 34   

TOC 36   

Materials Testers 39  

Particle Size 42 

Thermal 43   

High-speed Cameras 44  

Balances 45    

46
 Food & Fuels & Life Material
Environmental Beverages Energy Science Science Pharmaceutical

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 Analytical & Measuring Instruments Pocket Reference
SHIMADZU SCIENTIFIC INSTRUMENTS, INC.
7102 Riverwood Drive, Columbia, Maryland 21046, U.S.A.
Phone: 1(410)381-1227 Fax: 1(410)381-1222 Toll Free: 1(800)477-1227
www.ssi.shimadzu.com

Company names, product/service names and logos used in this publication are trademarks and trade names of
Shimadzu Corporation or its affiliates, whether or not they are used with trademark symbol “TM” or “®”.
Third-party trademarks and trade names may be used in this publication to refer to either the entities or their
products/services. Shimadzu disclaims any proprietary interest in trademarks and trade names other than its
own.

For Research Use Only. Not for use in diagnostic procedures.

The contents of this publication are provided to you “as is” without warranty of any kind, and are subject
to change without notice. Shimadzu does not assume any responsibility or liability for any damage, whether
direct or indirect, relating to the use of this publication.
© Shimadzu Corporation, 2016