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3
Structure of nucleotides
A nucleotide is made up of THREE
components:
1. A pentose sugar (5C)
2. A nitrogenous base
3. A phosphate group
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Structure of nucleotides
Nitrogenous base
Phosphate group
Covalent bond
Phosphoester
bond
Pentose sugar
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Structure of nucleotides: Pentose sugar
Pentose sugar
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Structure of nucleotides: Nitrogenous base
• Nitrogenous bases is attached to the carbon
number 1 of pentose sugar
• Two types of nitrogen bases:
1) Purines (double ring)
E.g.: Adenine (A) and Guanine (G)
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Structure of nucleotides: Nitrogenous base
• 2) Pyrimidines (single ring)
E.g.: Cytosine (C), Thymine (T) and Uracil (U)
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Structure of nucleotides: Phosphate group
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Phosphoester bond
Phosphodiester
bond
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Nucleotide component
DNAWatson
structure-and Crick
Watson andModel
Crick Model
• It is a polymer consisting
of two strands of
polynucleotide
• Coiled in a spiral to form
a double helix.
• Sugar and phosphate
group is linked by
phosphodiester bond to
form sugar backbone.
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Watson and Crick Model
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Watson and Crick Model
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Watson and Crick Model
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Watson and Crick Model
• The base pairs are
arranged at the
distance of 3.4 Å/ 0.34
nm from each other.
• One complete turn of
the helix is made up of
10 pairs of nucleotides
and the distance is
34 Å/3.4nm.
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RNA (Ribonucleic Acid)
The THREE main types
of RNA are:
1. Messenger RNA
(mRNA)
2. Ribosomal RNA
(rRNA)
3. Transfer RNA
(tRNA)
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1. Messenger RNA (mRNA)
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2. Ribosomal RNA (rRNA)
r RNA is contain in
ribosome.
the most abundant
type of RNA in cell.
Assist or involve in
protein synthesis
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3. Transfer RNA (tRNA)
The smallest RNA
molecules containing
75-80 nucleotides
Function of tRNA is
transfer or carry specific
amino acids to the
ribosomes for
polymerisation into
polypeptide chains
during translation.
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DNA &between
Comparison RNA compared
DNA and RNA
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Comparison between DNA and RNA
Similarities between DNA and RNA
• Both are nucleic acids.
• They are polymers containing
polynucleotide chain.
• Both have a sugar phosphate
backbone
• Both have four different types of
bases
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Differences between DNA & RNA
DNA RNA
consist of 2 long consists of a shorter single
polynucleotide strands polynucleotide strand
DNA RNA
chemically very stable chemically unstable
permanent existing temporary existing
only one basic form 3 basic forms ( mRNA, tRNA
& rRNA )
DNA carries genetic 3 different types of RNA are
information important in protein
synthesis
larger molecular mass smaller molecular mass