MISOPROST:

Abortifacient drug
in Egypt
Misoprost Composition
Each tablet contains: 200 mcg Misoprostol.

Misoprost Properties
Misoprostol is a synthetic analogue of alprostadil (prostaglandin E which is used in the prophylaxis and
treatment of peptic ulcers, particularly those induced by non-steroidal inflammatory drugs (NSAIDS).
Following oral administration, Misoprost (Misoprostol) is rapidly absorbed and metabolized to its active
form.

Misoprost (Misoprostol) has both anti- secretory (inhibiting gastric acid secretion) and mucosal
protective properties.

NSAIDS inhibit the synthesis of prostaglandin. the deficiency of which within the gastric mucosa may
lead to diminishing bicarbonate and mucus secretion and may contribute to mucosal damage.

In addition to its anti-secretory activity, Misoprost can increase bicarbonate and mucus production.

Misoprost Indications
Misoprost (Misoprostol) is indicated for the prevention of NSAIDS (non-steroidal anti-inflammatory
drugs, including aspirin)- induced gastric ulcers in patients at high risk of complications from gastric
ulcer, eg, the elderly and patients with concomitant debilitating disease, as well as patients at high risk
of developing gastric ulceration, such as patients with a history of ulcer, It has not been shown to
prevent duodenal ulcers in patients taking NSAIDS. It should be taken for the duration of NSAID therapy.
It has been shown to prevent gastric ulcers in controlled studies of three months' duration.

It had no effect, compared to placebo, on gastro-intestinal pain or discomfort associated with NSAIDS
use.

Misoprost Contraindications
 Allergy to prosraglandins.
 Pregnancy.
Misoprost Side Effects
Diarrhea, abdominal pain. flatulance, dyspepsia, nausea, vomiting, skin rashes, headache, constipation.
Gynecological disorders include spotting, cramps, menestrual disorder, hypermenorrhea,
dysmenorrhea, Post-menopausal vaginal bleeding.

Precautions and warnings

Misoprost should not be given to patients who are pregnant or who may become pregnant because of
its abortifacient property.

Misoprost is not excreted in human milk since it is rapidly metabolized throughout the body. However, it
is not known if the active metabolite is excreted in human milk. As such Misoprost should not be
administered to nursing mothers because the potential excretion of active metabolite could cause
significant diarrhea in nursing infants.

Dosage and administration

The recommended adult oral dose of Misoprost for the prevention of NSAIDS - induced gastric ulcers is
200 mcg four rimes daily for the duration of NSAID therapy.

Misoprost should be taken with a meal, and the last dose of the day should be at bedtime. If the 200
mcg dose cannot be tolerated, a dose of 100 mcg can be used.

Extra information
 Store at room temperature a way from light and humidity.
 Carton box containing two PVC / AI. strips of 10 tablets each with inner pamphlet.
 Misoprost manufactured by Chemical Industries Development (CID) For Multipharma Co.
 For more information, inquiries, and product request Whatsapp us: 00201061282386.
 AR- patient information leaflet- click here.
 EN- patient information leaflet- click here.