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Eight wonders of
the human brain
The more we learn about our command centre, the more
mysteries arise. New Scientist goes in search of the biggest
I
nside your head is an The human brain, we love to tell which releases more calories from food
object capable of feats of ourselves, is exceptional. Other animals to fuel this energetically expensive organ.
computation, creativity and might use tools or solve mazes, but can It isn’t only the number of neurons
understanding unrivalled in they invent computers or write sonnets? that matters, but also where they are.
the known universe – and all using Yet even with our extraordinary mental Our remarkable abilities probably stem
the power of a 20-watt light bulb. prowess, it isn’t easy to explain what from having more neurons in our cerebral
We have made huge strides in makes the human brain so special. At cortex – the brain’s wrinkly outermost
understanding the human brain. around 1.5 kilograms, our brains are layer – than other animals, says
In recent years, we have discovered about a third the weight of an elephant’s Herculano-Houzel. This structure allows
that brain cells can regenerate and and a fifth that of a sperm whale. us to develop more complex behaviours
pinned down what happens when If body size is taken into account, rather than simply responding to stimuli.
you start talking before you know however, our brains are unusually large: “If you have a cortex, you are no longer
what you want to say. Yet, the more between seven and eight times what a slave to what happens around you. You
we learn, the more we realise how would be expected for a mammal our have the flexibility to choose to do things
much we still don’t know. In the size. But this crude measure isn’t enough otherwise,” says Herculano-Houzel.
following pages, we explore the to explain our intelligence. The brain-to- What’s more, her team recently
biggest questions about the brain body-size ratio of a capuchin monkey is discovered that across warm-blooded
to reveal the mechanisms and higher than that of a gorilla, yet gorillas animals, the number of neurons in
mysteries of this phenomenal are considered smarter. the cortex correlates with longevity.
blob of grey goo. Clearly size isn’t everything. A more Herculano-Houzel thinks this is also
important metric might be the number a factor in our cognitive superiority:
of neurons – the brain’s processing units. humans take years to reach maturity. “We
Humans have about 86 billion, according take a really long time to put that brain
to Suzana Herculano-Houzel of Vanderbilt together,” she says. “All the while, you are
University in Tennessee, who has assimilating information from the world.”
pioneered methods to count them. Neurons aren’t the whole story: cells
In fact, primate brains have more called astrocytes also play an important
neurons than other mammal brains of role in intelligence (see “What makes a
comparable size. Humans, having the brain”, page 40). But the sheer computing
largest brain of any primate, also have power afforded by our 16 billion cortical
the most neurons of any primate, and neurons is likely to be the critical factor
probably any animal. This was possibly behind our cognitive dominance.
enabled by the invention of cooking, Sam Wong >
What is consciousness?
Think of the conscious mind as a furnace. as experiences. But the brain presents to says, the metaphor isn’t exact. When we feel
If you are deeply asleep, the flame of our consciousness only what matters to us, dizzy or pinpoint where a sound is coming
consciousness has died down to a low but and does so in a way we can understand. For from, for example, it is the result of physical
persistent level. In REM sleep, when you dream, example, it is why we see things as being a processes in the brain. Perhaps consciousness
the flame is jumping and burning brightly but particular colour. The real world isn’t like that, is more like a smartphone screen that presents
erratically. In a coma, it is a glowing ember. but our visual systems effectively colour-code different apps according to the amount of
Consciousness, in other words, exists in a the world for us, to simplify it. battery left or how much it has been shaken.
range of states. One explanation for this is that Consciousness, in other words, is a partial
full consciousness erupts when many parts of illusion, a picture knitted together by the brain
the brain broadcast information to a network Illusions of the mind as a result of all the inputs it is receiving and
of neurons known as the global workspace. Dennett argues that much as colour is the completeness of the brain broadcast.
When this broadcast doesn’t take place, an illusion created by the brain, so too is Rowan Hooper
sensations remain subconscious. When the consciousness. “Consciousness is a user
broadcast is incomplete, you get different illusion designed by evolution to make life
levels of consciousness, such as when you are easier for the brain that must guide a body
dreaming or have had a blow to the head. through a perilous life,” he says.
By studying these states, we should one day
be able to pinpoint the brain mechanisms that
Smartphone designers call the screen of
a phone a user illusion. The screen is the “If our brain is
give rise to consciousness. So why then, has
explaining consciousness – how a kilogram
interface to the computer underneath, but the
icons on it – such as the envelope that depicts
a smartphone,
or so of nerve cells conjures up the swirl of
thoughts and emotions that make up our
a message – are symbolic, and don’t bear any
relation to the actual hardware and software of
consciousness
mental experience – been dubbed “the hard
problem”? One reason is that philosophers
the phone’s messaging system. If our brain is a
smartphone, consciousness is the screen, our
is the screen”
have focused on explaining how we become interface to the brain. However, as Churchland
aware of experiences. Their term “qualia”
Gamma brainwaves
describes the properties of experiences we
have, such as the redness of a strawberry or
the perception of the taste of wine. Trying to
find explanations for qualia has caused no
end of confusion among neuroscientists.
One solution to the problem is to ignore
it. “‘Qualia’ is a term of art, introduced by
philosophers who want to make the questions Neural
about the nature of consciousness answerable ripples
only by spooky, non-biological accounts,” Gamma waves
says Patricia Churchland at the University are one of
of California, San Diego. After all, we don’t five types of
normally talk about our qualia, we talk about brainwave,
things such as being tired, needing to eat each oscillating
or even being in love – feelings that have a at different
straightforward, non-spooky biological origin. frequencies and
Most people aren’t aware of their qualia associated with
until they are prompted by philosophers, different tasks.
says Daniel Dennett of Tufts University, The others are
Massachusetts. Dennett not only thinks alpha, beta,
that there is no hard problem, he believes delta and theta
consciousness itself is a kind of illusion. waves
“It takes some substantial coaxing and cajoling
to get people to ‘notice’ their qualia,” he says,
“and when they think they do notice them,
they are falling for another illusion.” When we
The illusion, according to Dennett, is this: consciously
PLAINPICTURE/SILVERI
Is your brain
ever off?
circumstances. Bottom-brained types When you rest, it sometimes feels as if your opportunities, and that requires a brain that
think through the details of a plan but are brain switches off too. It doesn’t. If you are is working constantly.
less likely to initiate complex schemes. alive, your neurons are firing. “There is a lot Back in the 1990s, neuroscientists noticed
Anderson, however, posits that our of processing going on even when you’re not that people lying quietly in brain scanners with
personalities probably arise from the way seemingly doing anything at all,” says Deniz their eyes closed showed surprising levels of
various brain systems are connected and Vatansever, a cognitive neuroscientist at brain activity. The researchers soon mapped
how rich those links are. For instance, Fudan University in China. the brain regions that are most active during
people who are open to new experiences It could hardly be any other way. Moment- rest, and this became known as the default
are more likely to get goosebumps when to-moment readiness was a matter of life mode network. This shows little activity when
they see a beautiful sunset. Brain scans and death for our ancestors. These days, we are engaged in tasks requiring attention,
show that they have more connections most of us don’t have to worry about but fires up when we “switch off”, allowing our
between areas that process sensory leopards leaping from the undergrowth. minds to wander.
information and regions responsible But we still need to be alert to dangers and Some evidence suggests that the default
for our inner voice. mode network is involved in mulling over past
We can feed this information into experiences and speculating about the future.
deep-learning machines that can make In that sense, it is vital because daydreaming
accurate predictions about personality
~1 petabyte
is considered to be one of the abilities that sets
traits based on a person’s brain scan, says us apart from other animals. But the default
Anderson. “It’s not about anyone using mode network does more than that. In 2017,
the left or right side of the brain more,” Vatansever and his colleagues demonstrated
he says, “it’s about subtle differences in that it underlies our ability to do certain things
connections across the whole brain.” Estimated memory without paying attention, such as tying our
Helen Thomson capacity of the shoelaces or driving along a familiar route –
human brain our autopilot mode.
[equivalent to that of the
World Wide Web]
SOURCE: ELIFE, DOI.ORG/GDZ74X
Shutting down
The brain is a hive of activity during sleep,
too. Once consciousness is lost, it gets to work
on all manner of chores: clearing out toxic
molecules, regulating hormone levels and
conjuring dreams, which are thought to
provide a safe environment to simulate
new behaviours that could help during
waking life. The sleeping brain also files
away experiences for later recall.
Even when someone is in a vegetative state,
unconscious and apparently unresponsive
for a prolonged period, their brain continues
to work at some level. When some people in
this state are asked to imagine themselves
playing tennis, for instance, blood flow
increases in brain regions associated with
motor skills, suggesting that the neurons there
are firing. In one case, a patient seemingly
activated those regions on command in
response to yes-or-no questions.
Only when you die do your neurons
completely shut down. Except even then,
there is a final burst of activity, as Jed Hartings
at the University of Cincinnati in Ohio and his
colleagues recently showed for the first time in
humans. When the heart is no longer pumping
blood to the brain, starving it of oxygen,
neurons draw on energy reserves to continue
firing for up to 3 minutes before they produce
one last burst of electrochemical energy. Only
then is the brain switched off for good.
Daniel Cossins >
We often say we make decisions on the basis a hallmark of the disease, seem to appear
of gut feelings, and this may be truer than we first in the gut before spreading to the brain.
realise. Nausea, for instance, makes us judge We don’t know what triggers it, but it could
certain moral violations more harshly. This be an unknown microbe or toxin. In epilepsy,
is just one of many ways in which our gut changes to the microbiome may explain
influences what goes on in our head. why the high-fat “keto” diet prevents seizures
It is easy to forget that the gut is a sense in some people.
organ, detecting incoming nutrients, toxins Research on the gut-brain connection
and pathogens, and relaying that information is in its infancy, but it has sparked the idea
A few years ago, scientists took electrically active. These are roam the brain gobbling up foreign “While neurons are still very
human brain cells and injected known as glial cells, and they are material to protect the neurons. important, it seems that glial cells
them into mice. A year later, the at least as numerous as neurons. Astrocytes take care of the are involved in setting the gain on
cells had multiplied and the mice A type of glia called an astrocyte neurons’ environment too, the system,” says Ed Lein at the Allen
had got smarter, learning more was injected into those mouse controlling levels of chemical Institute for Brain Science in Seattle.
effectively than mice with regular brains, suggesting – not for the messengers known as It isn’t all about cells. Holes play
brains. Perhaps that isn’t so first time – that they could be neurotransmitters and helping a part too. Deep inside your head
surprising – until you hear that important in learning. to repair damage. Evidence is there are slim chambers called
these brains cells weren’t neurons. Glia used to be considered mere mounting that these cells also have ventricles that produce the fluid
As building blocks of the brain go, gap fillers. No longer. “There is a role in the development of human that bathes the cells of your brain.
neurons hog the attention. There a lot of evidence to say they are intelligence. We know that babies We make as much as 500 millilitres
are some 86 billion of these stringy more than just glue,” says Anne start off with many connections of this cerebrospinal fluid daily,
cells carrying electrical impulses Cooke, chief executive of the British between their neurons and that which keeps everything in working
around the brain, helping us to Neuroscience Association. “They these are gradually pruned down to order by providing cushioning and
control our bodies and think are the unsung heroes of the brain.” create smaller numbers of stronger nutrients, and washing waste away.
thoughts. But there are plenty They come in different types. Small signalling pathways. Astrocytes, it There is no doubt plenty more
of cells in the brain that aren’t ones called microglia, for instance, seems, are involved in this pruning. to be discovered. Just last year,
It is a harsh fact of life: as you get older, wrong before you start to notice it
your cognitive abilities start to wane. slowing down.
But why is it that some people reach Our environment can also influence
a ripe old age with little more than the cognitive reserve. A high level of
odd “senior moment”, while others education offers one of the biggest
have far greater mental decline? boosts, whereas obesity and insulin
The brain starts shrinking around resistance seem to reduce it. Several
the age of 40, with cells deteriorating genes also help us resist cognitive
most quickly in the frontal lobe, the decline. Tiny genetic variations are
striatum and the hippocampus – areas associated with our susceptibility to
involved in our most complex thoughts, Alzheimer’s as well as with how the
movement and memory. How resistant brain utilises energy reserves and
you are to the effects of this decline reacts to injury and pathogens.
is likely to be associated with your
cognitive reserve. This is a kind of
mental buffer that allows your brain Exercise the mind
to sustain more damage before you Brain shrinkage over time sounds bleak,
notice changes in your cognition. but there is some good news. Although
Cognitive reserve isn’t just down to most of our brain cells are created soon
someone having more neurons than after birth, we can make certain types of
another person, but also to how well neuron even into our 90s. This ability
their neurons engage with each other might go some way in explaining why
Beta brainwaves across different networks in the brain. some people’s brains fare better against
Mind reading: This allows the brain to compensate the ravages of old age.
new technology when age-related decline occurs or There are a few other ways to boost
gives us an disease takes hold, and helps reroute cognitive reserve. Continuing to
unprecedented information so that the organ can educate yourself throughout your life
view of the continue to work optimally. It is a bit appears to provide one of the biggest
brain in action like boosting the processing power benefits, but playing a musical
in a computer: more things can go instrument, socialising, getting the
right amount of sleep and speaking
more than one language also help.
Don’t put your feet up for too long
though: the adage “healthy body,
healthy mind” turns out to be true.
“If you’re looking to maintain brain
health, you need to exercise,” says
Steve Harridge, director of the Centre
for Human and Applied Physiological
Sciences at King’s College London.
Regular workouts bring about
significant improvements in memory,
researchers identified a new type attention, processing speed and
of brain cell, dubbed a rosehip executive functions, such as planning
neuron due to its resemblance and multitasking.
to the shape of a rosebush fruit. And don’t leave it too late. Richard
It may only exist in humans. Henson at the University of Cambridge
Other secrets may well be and his colleagues have discovered that
revealed by Lein’s ongoing efforts the things we do in midlife – outside of
to create a map of all the brain’s cell work and education – make a unique
K.H FUNG/SCIENCE PHOTO LIBRARY