Syllabus P.G PDF

1
Expert advice from the following academicians has been incorporated in the proposed
syllabi-
1. Prof. Biman Bagchi

Solid State and Structural Chemistry Unit
Indian Institute of Science, Bangalore
2. Prof. S. K. Mehta
Chemistry Department
Panjab University, Chandigarh
3. Prof. Ashok Mukharjee

University of Burdwan, West Bengal
4. Prof. M. S. Chauhan
H. P. University, Shimla
5. Prof. V. K. Rattan
Department of Chemistry and Engineering, Chandigarh
6. Prof. Ashok Kumar Prasad

Department of Chemistry
University of Delhi, Delhi
7. Prof. Isabel Rozas

School of Chemistry
Trinity College, Dublin, Ireland
8. Prof. P. Venugopalan
Panjab University, Chandigarh
9. Dr. Deepak Chopra

Department of Chemistry
IISER, Bhopal
Course contents of the following Universities have been taken into account to prepare the
proposed syllabi-
1. Panjab University, Chandigarh

2. University of Delhi, Delhi
3. Maharishi Dayanand University, Rohtak
4. Banaras Hindu University, Banaras
5. University of Dublin, Ireland
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Syllabi and Courses of Reading for M.Sc. Chemistry (Previous and Final) Classes w.e.f.
2013-2014 and 2014-2015.
SCHEME OF EXAMINATION
Paper No. Nomenclature of the Paper Max. Time
Marks
(Including internal assessment)
M.Sc. (Previous)
Semester I
I Inorganic Chemistry (General) 60+20 3 hrs.
II Physical Chemistry (General) 60+20 3 hrs.
III Organic Chemistry (General) 60+20 3 hrs.
IVa Chemistry of Life Science 60+20 3 hrs.
OR
IVb Mathematics for Chemists 60+20 3 hrs.
OR
IVc Introduction to Pharmacy 60+20 3 hrs.
and Pharmacology
Semester II
V Inorganic Chemistry (General) 60+20 3 hrs.

VI Physical Chemistry (General) 60+20 3 hrs.
VII Organic Chemistry (General) 60+20 3 hrs.
VIII Applications of Computer 60+20 3 hrs.
in Chemistry
IX Inorganic Chemistry Practicals 80+20 6 hrs. (Two sessions)
X Physical Chemistry Practicals 80+20 6 hrs. (Two sessions)
XI Organic Chemistry Practicals 80+20 6 hrs. (Two sessions)
M.Sc. (Final)
Semester III
XII Inorganic Chemistry (General) 60+20 3 hrs.
XIII Physical Chemistry (General) 60+20 3 hrs.
XIV Organic Chemistry (General) 60+20 3 hrs.
XV Inorganic Chemistry (Special) 60+20 3 hrs.
XVI Inorganic Chemistry (Special) 60+20 3 hrs.
OR
XV Physical Chemistry (Special) 60+20 3 hrs.
XVI Physical Chemistry (Special) 60+20 3 hrs.
OR
XV Organic Chemistry (Special) 60+20 3 hrs.
XVI Organic Chemistry (Special) 60+20 3 hrs.
OR
XV Pharmaceutical Chemistry (Special) 60+20 3 hrs.
XVI Pharmaceutical Chemistry (Special) 60+20 3 hrs.
3
Semester IV
XVII Inorganic Chemistry (Special) 60+20 3 hrs.
XVIII Inorganic Chemistry (Special) 60+20 3 hrs.
XIX Inorganic Chemistry (Special) 60+20 3 hrs.
XX Inorganic Chemistry (Special) 60+20 3 hrs.
OR
XVII Physical Chemistry (Special) 60+20 3 hrs.
XVIII Physical Chemistry (Special) 60+20 3 hrs.
XIX Physical Chemistry (Special) 60+20 3 hrs.
XX Physical Chemistry (Special) 60+20 3 hrs.
OR
XVII Organic Chemistry (Special) 60+20 3 hrs.
XVIII Organic Chemistry (Special) 60+20 3 hrs.
XIX Organic Chemistry (Special) 60+20 3 hrs.
XX Organic Chemistry (Special) 60+20 3 hrs.
OR
XVII Pharmaceutical Chemistry (Special) 60+20 3 hrs.
XVIII Pharmaceutical Chemistry (Special) 60+20 3 hrs.
XIX Pharmaceutical Chemistry (Special) 60+20 3 hrs.
XX Pharmaceutical Chemistry (Special) 60+20 3 hrs.
XXI Inorganic Chemistry Practicals 80+20 18 hrs.

XXII Inorganic Chemistry Practicals 80+20 (six sessions
XXIII Inorganic Chemistry Practicals 80+20 spread over three days)
OR
XXI Physical Chemistry Practicals 80+20 18 hrs.
XXII Physical Chemistry Practicals 80+20 (six sessions,
XXIII Physical Chemistry Practicals 80+20 spread over three days)
OR
XXI Organic Chemistry Practicals 80+20 18 hrs.
XXII Organic Chemistry Practicals 80+20 (Six sessions,
XXIII Organic Chemistry Practicals 80+20 spread over three days)
OR
XXI Pharmaceutical Chemistry Practicals 80+20 18 hrs.
XXII Pharmaceutical Chemistry Practicals 80+20 (six sessions,
XXIII Pharmaceutical Chemistry Practicals 80+20 spread over three days)
Seminar 40
Grand Total 2000 marks
Tutorials 1/2 hr. per paper per group

Note: 20% marks are reserved for Lab. Record in Practicals in M.Sc. (Previous) and M.Sc.
(Final).
4
(Modified Syllabi)
M .Sc. Chemistry (Pre vious)

I norga nic Che mistry (Ge neral) Pape r I
Time : 3 Hrs
M ax. M arks : 60+20(I A)
Note: Eight ques tions will be se t, two from each of the sec tions A, B, C & D.
The candidates are re quired to atte mpt five ques tion s in all selectin g at
least one que stion from each s ection . All questions carry eq ual marks .
S ECTION – A
Sy mme try a nd Gro up The ory i n C he mistry

Def in it io ns o f gro up , su b group , relat ion b et we en o rders of a finit e g ro up a nd it s
su b group . Con jug acy relat io n and c la ss es. S ymmet ry ele ment s an d s y mmetr y
op era tion, P o in t s ymmet r y g roup . Sch önfl ie s symb ols , rep res en ta tions o f g roup s b y
mat rices (rep resen ta t ion for th e C n , C n v , C n h , D n h etc. grou p s t o b e work ed out
ex p licit l y) . Character o f a r ep res ent at ion , red ucib l e a nd irreducib l e rep res ent at io ns ,
T he grea t o rt hog o nal it y th eor em ( wit hou t p roo f) an d its i mp ortan ce, De rivat io n o f
ch ara ct er ta b les o f C 2 v , C 3 v an d D 2 h Cha ra ct er t ab les an d t heir u s e. Mo l ecu la r
as ymmet ry , d iss y mmet ry and o p tica l act iv it y.
SE CTION - B
Stereochemis tr y a nd Bo nding i n Ma i n Gro up Co mpo und s
VSEP R T h eory, Wa lsh d iagra ms (t ri- a tomi c mo lecu les ), d  -p  b on ds, Bent ru l e
an d en erg et ics of h yb rid iz at ion , Hu ck e l t heo ry wit h re feren ce t o eth y lene a nd
b u tad iene, So me si mp l e s ub s titu tion rea ct i on s of co valen t l y b o nded mo lecu les o f
b o ron , s i lico n a nd n it rogen .
S ECTION – C
Meta l-Lig a nd Equil ibr ia i n So lutio n
St ep wis e and ov era ll fo r mat io n co nst ant s a nd t he ir int eract ion , tr end s in
st ep wis e cons ta nt s, fact ors affectin g th e st abi lit y o f meta l co mp lex es with r eference t o
t he n at ure of met al io n a nd l ig and , chelat e e ff ect an d its t her mod yn amic o r ig in,
determinat io n o f b inar y for mat ion c ons ta nts b y p H-metr y a nd sp ect ro p hot omet r y.
Su b st it ut io n rea ct ion s in octah ed ral comp l ex es, t heo ries o f t ra ns effect with resp ect t o
Pt (II) comp lex es , b rief a cco unt of elect ron trans fer r eact ions , in ert and lab ile
co mp lex es .
5
S ECTION - D
Meta l-Lig a nd Bo nding

Li mit at io n o f c rysta l fi eld t h eory , cryst al field ef fects , Joh n T ell er d is to rti on,
nep helau x et ic s eries , sp in -o rb it a l cou p ling , mo lecu lar orb it al t heo ry o f o ct ahedra l,
t etrah edra l a nd sq u are p la nar c omp l ex e s (wi t h an d wit hout п -b on ding ).
Boo ks Sug ges ted
1. Adv anced In o rg ani c Ch emist ry, F. A. Cot ton a nd W ilkin son , Jo hn Wi l ey.
2. Inorgan ic Che mis tr y, J .E . Hu hey , Harp er & R ow.
3. Chemical Ap p licat ions o f G roup T h eor y; F.A . Co tt on , W ile y, New Yo rk.
4. Chemis tr y o f th e E le ment s , N. N. G reen wood an d A. Earnsh a w, Pe rga mon .
5. T he Ch emi cal b ond ; J. N.Mu rre l, S FA Kett le a nd JM. T edd er; W iley , N ew York .
6. Modern As p ect s of Ino rga nic Ch emis t r y; H.J . E meleus an d Sharp e.
7. Con cep ts an d Mo dels of Ino rgan ic Che mis tr y; B. Do ug las, D.H. McDan ie l a nd .
J.J. Al ex a nder; J ohn W il ey an d S ons .
8 . Inorgan ic Che mis tr y, A Mo d ern Int ro du ction; T Moe ller, Joh n Wi le y and So ns .
M .Sc . Chemistry (Pre vio us) Se me ste r I

Phy sical Chemistry (Gene ral) Paper I I
Time : 3 Hrs
Note: Eight ques tions will be se t, two from each of the sec tions A, B, C & D.
The candidates are re quired to atte mpt five ques tions in all selectin g at
least one que stion from each s ection . All questions carry eq ual marks .
S ectio n - A
Rea l Ga se s: Co ncep t o f Fug a city a nd Ac tiv ity
Recap it ula tio n o f t her mod ynami c la ws . C on cep t of fu gac it y, met h ods fo r
determin in g t h e fu gac it y o f a rea l ga s, its va riat ion with t emp erat ure an d p ressu re,
activ it y, ch o ice o f st an dard st at es , d ep en den ce o f act iv it y on t emp erat ure a n d
p res sure, det er min ation o f a ct iv it y b y (i) mea sur ement o f v ap ou r p res su re, (i i )
dist rib ut ion o f so lu te b et ween t wo i mmis c ib le s olv ent s , ( ii i) emf mea suremen t and ( iv )
activ it y o f o ne co mp onent fro m kno wn va lue of t h e act iv it y of t he ot he r.
Pa r tia l Mo la r Pro per ties
Pa rt ia l molar q uan tit ies , ch emical p ot ent ia l an d G ib b s -Duhem eq ua tion,

va riat ion of chemica l p ot ent ia l wit h temp era tu re an d p res su re, ch emi ca l p ot ent ia l fo r
6
an idea l gas , che mica l p ot ent ial in id ea l ga s mix tu re , det er mina tio n of p art ial mo la r
vo lu me , t he rmod ynami c funct ions o f mix i ng (fr ee ene rg y, entrop y, v o lu me an d
en tha lp y), con cep t o f es cap in g t en d enc y and ch emica l p ot ent ia l.
SECTION - B
Che mica l Kine tics
Col lisio n th eor y o f rea ct io n rat es, t h e st er ic req ui re ment , A rrh en ius eq uat io n
an d a ct iva ted comp lex t heor y (ACT ), co mp aris on o f co ll is ion an d a ct iv ation co mp lex
t heor y, Po tent ial en erg y s u rfaces (O n ly b as ic Id ea) , th ermo d yn amic fo rmu lat io n o f
activat ed co mp lex t heory , cha in react ions (h yd rogen -h alog en r eact ion) , uni mo l ecu la r
react ions , L ind ema nn – H in she lwoo d mecha n is m o f un imo l ecu la r react io ns.
S ECTION – C
Electrochemistry
Deb ye-Hü ck el t h eo ry of ion - io n int era ct io n a nd act iv it y co eff ic ient ,
ap p lica b ilit y an d li mit at ion s of Deb ye-Hü ck el l imiti ng la w, it s mod i f ica ti on fo r fin it e -
sized io ns , ef fect of io n-s o lv en t in terac tion o n act iv it y co effi cient . Ph ys i cal
sign if ica nce o f act iv it y co eff ic ients , mea n a ct iv it y coeffi cient of an el ect ro l yte .
Deb ye-Hu ck el -O ns ager (D -H-O ) th eor y o f elect ro l yt ic cond u ct an ce , D eb ye -
Fa lkenha gen effect , We in effect . D-H -O equa tion - it s ap p licab il it y and li mitat ions ,
Pa ir-wis e as soc iat ion o f io ns (B jerru m t reat ment ), Mo d if icat ion of D -H -O theor y t o
accou nt for io n-p air fo r mat io n .
Met al/E lectro lyte int erface , Con cep t of el ect rical d o ub le la yer a nd it s st ru ctu re:
Helmho lt z-P err in , G ou y-Chap ma n, and S tern mod els, e le ct rok in et ic p h eno mena ,
determinat io n o f zet a p ot en t ial .
SECTI ON-D
Sur fa ce Che mistry a nd Ca ta ly sis
G ibb s ads orp tion eq ua tion, Lan g mu ir ad s orp t io n is ot her m and it s k inet i c
derivat io n for n on- d iss o ciat iv e and diss o ciat iv e ads orp tion , B ET a dso rp t ion is oth er m,
its k in et ic der iv ation an d ap p licat io ns.
Study o f surfaces b y ST M, SEM. He terogeneou s catalysis, surfac e

he teroge neity, surfac e catalyzed u nimolecu lar and bimole cular reac tions,
temporary and pe rmanent c atalytic poison s, activation energy for surfac e
re actions. Co mp arison of h omogeneous and hetero geneous reaction rates.
7
Boo ks Sug ges ted
1. An Int ro du ct ion to Chemi ca l T her mod y namics , R.P . Ra st ogi an d R.R. Mis ra,
Vikas Pu b .
2. Ph ys ica l Ch emist ry, P.W. At k ins , O x fo rd Un i vers it y Pres s .
3. T hermo d yna mics fo r Ch emist s , S . G las st one , Aff il ia ted East -West Pres s .
4. T hermo d yna mics , I.M . Kl ot z a nd R.M. Rosen b ers, Benz amin .
5. Chemical Kinet ics, K.J. L a id ler, McG ra w H il l .
6. Kin et ics and Mechan is m, A. A . Frost a nd R . G . Pea rs on, J ohn W il ey a nd Sons .
7. El ect ro ch emis t r y, S. G las st one , Aff il ia ted East -West Pres s .
8. Ph ys ica l Ch emist ry, G .W . Ca st ellan , Narosa .
9. Heterogeneous Catalysis : Fu ndame ntals and App lications, Julian R.H.
Ros s, Wiley-VCH; 2nd, Revised and Enlarged Edition edition (October 1,
200 7)
10 . Conc epts o f Modern Catalysis an d Kinetics , I. Chorkendorff and J. W.
Nie mantsve rdriet
M.Sc. Che mis try (Prev io us) S e mes ter I

Org a nic C he mis try (Ge nera l) P a per I II
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)
No te: Eight q ues tio ns wi ll b e s et, t wo fro m each of t h e se ct ion s A , B, C & D . T h e

ca ndidat es are req ui red t o a tt emp t five q u est io ns in al l sel ect ing at least on e
q u est io n fro m each s ect io n. A l l q uest io ns ca rry eq u a l marks.
S ECTION – A
Rea ctio n Mec ha nis m: Struc tur e a nd Rea ctiv ity
T yp es o f mech an isms , t yp es o f react io ns , th er mod yn a mic and ki net ic

req uire ment s , e ff ect o f s tru ct ur e on react iv it y - r es ona nce and field effects, s t eri c
effect , q u ant it at iv e treat men t . T he Hammett eq u ation a nd lin ear fr ee en erg y
rela tions h ip , s ub s tituent a nd react io n con st ant s. T a ft eq ua tion, k in et ic an d
t her mod yn ami c co nt ro l, Hammond 's p o st ula te, Cu rt in -Ha mmett p rin cip le . P otent ial
en erg y diagrams , tran sit ion st at es and int ermed iates , meth ods of dete rmin ing
mechan is ms , G en era tion , st ru ctu re , st ab il it y and r ea cti vit y o f ca rb o cat ions,
ca rb a nions , carb enes a nd n itr enes .
8
SE CTION - B
M echa nis m of Nuc leo philic Alip hatic S ubstitution
The limiting cas es SN 1 and SN 2 , detailed mechanis tic descrip tion and
border line mechanisms, nucleophilic ity and solvent effects, competition
be tween nuc leophilicity and basic ity, ambident nuc leo philes , h ard and soft
nuc leophile s and electrophiles , leaving group effec ts , steric and o the r
substituen t effe cts on substitution and ionization rate s, s te reochemistry o f
nuc leophilic subs titu tion, SN i , S N 1 ' , S N 2 ' and S N i' me chan is ms .
M echa nis m of E liminatio n Reac tions
The El, ElcB and E2 mech anism, Orie ntation Effe cts in Elimination
Reactions , Saytzeff an d Hoffm an rule s, Ste reochemistry o f E2 Elimination
Reaction and Eclips ing Effects in E2 Elimination s. Dehydration of Alcoho ls,
Elimination not involving C -H Bonds, P yrolytic elimin ations .
SECTION – C
Stereochemistry- I
Symmetry ele ments , D-L, R-S, E -Z and threo -eryth ro no menclature,
inte rconversion of Fische r, Newman, S awh ors e and fl ying wed ge formulae.
conformational analys is, e nantio me rism and d ias te reo me rism of s imple, cyc lic
(c hair and boat configu rat io n) and acyclic sys tems . Axial and planer chirality,
optic al isomerism in allenes, biphenyls (at ro poisomeris m), spiranes,
he mispiranes . elementary id eas about stere oche mistry o f te rtiary amines,
quate rnary salts, su lphur and phosphorou s compounds.
S ECTION - D
Stereochemis tr y – II
Top icity of lig ands and fac es, their nomenclature and prostereoisomeris m,
stereogenecity, c hirogenic ity, pseudoas ymmetry and proch iral c entre.
stereospecific and stereoselective re action.
Elementary idea of principle cate gories of as ymmetric synthesis, Cram’s rule

an d its mod ification, Prelog rule and horeau s rule.
Stere oche mistry o f su gars- C1 and 1C confo rm ation s o f h exos es, c 2 ’-en do and
c 3 ’-endo con formation of p entose s, homomorphou s sugars, a bnormal
mutaro tation and ∆-2 instability factor.
Stere oche mistry o f d ecalins,

9
Che mical correlation of c onfiguration -de termination of re lative c onfigu ratio n o f

2-butanol, isoserine, alanine, malic ac id, l actic acid and mandelic acid .
Books Suggeste d
1. Ad vanc ed Organ ic Chemistry Reactions, Mech anism and Structu re, J erry
March, John Wiley.
2. Ad vanc ed Organic Che mistry, F. A. Care y and R. J . Sundberg, Plenum.
3. A Guide Book to Mech anism in Organic Ch emis try, Peter S ykes, Longman .
4. S tructure and Mechan is m in Organ ic Chemistry, C. K. Ingold, Cornell
Un ive rsity P res s.
5. Organ ic Chemistry, R. T . Morris on and R. N. Boyd , Pre ntice -Hall.
6. Modern Organic Reactions, H. O. House , Benjamin .
7. P rinciple s of Organic Synthe sis , R. O. C. Norman and J . M. Coxon,
Blac kie Academic & P ro fe s sional.
8. Re action Mechanism in Organic Chemistry, S . M. Mukherji and S . P.
S ingh, Macmillan.
9. Stere oche mistry o f Organic Compounds, D. Nasip uri, New Age
Internation al.
10. S tereochemistry o f Organ ic Compounds, P.S, Kals i, New Age
Inte rnational.
M.Sc. Che mis try (Prev io us) Se mes te r I

Che mistr y o f L i fe Sc ience Pa p er IVa
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)
No te: Eig ht q u est ions wi ll b e s et ; t wo wi ll b e set fro m s ect io n A an d t hree fro m each
of t he s ect io ns B & C. T he cand ida tes a re req u ired to at t emp t fiv e q ues tion s in
all se lect ing a tl eas t on e q ues ti on fro m each s ect ion .
S ECTION - A
Cel l Struc tur e a nd Meta bo lis m
St ructure o f p rok aryot ic and euka ryot ic c el ls , int rac el lu lar organ ell es an d th eir
fu nct io ns , co mp aris on of p lant a nd ani mal cells . O v erv ie w of metab olic p rocesses -
cat ab olis m and a nab ol is m. AT P - t he b iolog ica l energ y cur ren cy. Carb o hydrat e
met ab o lism-g lycol ysis , Kr eb 's cy cle, g l ycog en o lys is, g l ycog en es is p ent ose p h osp hat e
p at hwa y a nd g lu con eog enes is ,
10
Ca rbo hy dra tes
St ru ctu re and fun ct ion s o f imp ort an t deri vat iv es o f mo nos acchar id es l ik e
gl yco s ides , d eo x y sug ars , myo ino s ito l , amin o su gars -N -acet yl mura mic ac id an d s ia lic
acid , d isac cha rides
St ructure a nd b io log ica l fu n ct ion s o f St ru ctu ra l p o lysaccha rid es - c el lu los e a nd

chit in .St ora ge p o lys acchar id es -st ar ch an d g ly cogen .
Het erop ol ys acchar id es-g lu co saminog lycans or mucop o lys acchar id es .

G ly cocon ju ga tes- g lycop rot ein s an d gl yco l ip id s. Ro le of s uga rs in b io log ica l
recog n it io n. Blo od g rou p s ub s ta nces.
SE CTION - B
Lipid s
Fat ty acids , es s en tia l fat t y aci ds , st ru ct ure and fun cti on o f tr ia cylg l yce ro ls ,
gl ycerop hos p holip id s , sp hingo lip id s, ch o lest ero l, b i le a cids , p ros tag la ndins .
Lip op rot eins - co mp osit ion a nd fun ct ion , ro le in ath erosc leros is .
Pro p erties o f l ip id aggreg ates- micell es , b ilayers , lip o somes an d th ei r p o ssib le

b iolo g i cal fu nct io ns . Bio lo g ical me mb ra nes . F lu id mos ai c mod el o f memb ran e
st ru ctu re.
Lip id met ab olis m - β-ox ida tion o f fatt y acids .
A mino -a cids, P ept ide s a nd Pro te in
Es sen t ial a mino a cid s, Is oe le ct ri c p H,chemi ca l and enzyma t ic h yd ro l ys is of p rot eins t o

p ep tides, amino ac id s eq uencing . Se con dar y structu re of p rote in s , fo rc es resp o nsib l e
for h o ld in g of s econ dar y s tr uct ur es . α -he lix , β-s heets , sup er s econda ry st ru ctu re,
t rip le he lix structure o f co l la gen . T ert iar y s truct ur e o f p rot ein - fo ld in g an d d oma in
st ru ct ure. Q ua terna ry st ru ct u re . den at ura tio n of p rot eins
S ECTION – C
Nuc le ic Ac ids a nd Ge net ic Co d e
St ru ctu re of n ucl eot id es , nu cleo s id es , DNA (Wa ts on -Crick mode l) RNA st ru ct u re an d

co nfo rmat ion,
St udy o f pr o ka ryo tes
Rep li ca tion o f DNA (s emi-conse rv ativ e, cons erv at iv e and dis p ers iv e rep li ca t ion
Mas elson-St ahl ex p eriment) , trans cr ip t ion , tran sla tion of g en et ic ma teria l, g en et ic
co de, u n iv ers al it y of th e cod e, codo n , an ti cod on p airing , RNA , p rot ein b io s ynt hes is
(in it iat io n, e lon gat io n , t ermina tion and p roc ess in g of th e p ep t ide cha in ).
11
Boo ks Sug ges ted
1 . Prin cip les of Bio ch emis t r y, A . L . Lehn in ger, Wort h Pub lish ers .
2 . Bioch emis tr y, L .St ryer, W.H .F ree man.
3 . Bioch emis tr y, J . David Rawn , Nei l Pat ters on .
4 . Bioch emis tr y, Vo et an d Vo et , Jo hn Wi ley.
5 . O ut lin es o f B io che mis tr y, E. E .Co nn and P. K. St ump f, Joh n W i le y.
Or
M.Sc. Che mis try (Prev io us) Se mes te r I

Ma the ma tics fo r C he mis ts Pa pe r IV b
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)
No te: Eight q u est io ns wil l b e s et, t wo f ro m s ect io n A and t hre e fro m ea ch of th e

sect ions B & C. T h e can d id at es ar e req uired t o a tt emp t f iv e q ues t ions in al l
sel ect ing at leas t on e q uest io n fro m ea ch section . A ll q u est io ns ca rr y eq ual
ma rk s.
S ECTION - A
V ec tor s
Ex a mp les of sca la r a nd vectors , d efin it ions of ve ct ors in t wo , t hree s p aces ,

rep rese nt ation an d s imp le p rop ert ies of v ect ors, ad d it ion and su b traction of v ecto rs,
vect or addit ion b y th e met ho d of t riang les , reso lut ion o f v ecto rs in to rect angu la r
co mp onent s , ad dit ion of v ecto rs b y co mp onent s, mu ltip l icat ion an d d iffe ren t iat io n o f
vect ors . S calar p ro duct o f v ecto rs , ve ct or p rod uct , co nc ep t of nor ma liza tion ,
orth ogon al it y an d co mp lete set of un it v ecto rs . Ill ust ra tion of a p p licat ion s t o
sp ect ro scop y an d q uan tum ch emis tr y.
Ma tric es a nd De te rmina nts
Def in it io n o f matr ix , t yp es of ma trices , v iz . ro w mat rix , co lu mn ma tr ix ,

nu ll mat rix , s q uare mat rix , diago nal mat rix , a ddition , s ub t ra ct ion an d mu lt ip licat io n
b y a n u mb er, mat rix mu lt ip l i cat io n . T rans p os e a nd a djo in t o f matr ix , element ar y
t ran sforma tion , r ep res ent at ion an d ap p licati ons ( wit hou t d ev e lo p me nt of t h eo ry) t o
so lu t ion of lin ea r eq ua tions . Defi nit ion o f deter min ant , p ro p ert ies o f det erminant s,
ev aluat io n o f d et ermina nts . Il lu st rat ion o r app licat io ns to g roup t heo ry, p rob lem s in
ch emistr y.
SE CTION - B
Log arith m
12
Need for lo garit h m in ch emist ry. T h eo r y a nd app licat ion o f logar it h ms fo r

so lv ing g en era l a nd ch emical p rob lems .
Gra phica l Re pre senta tio n o f Equa tio ns

Recta ngu lar coord in at es , s traight lines , s lo p e an d interc ep t of t he eq ua tion,
slop e a nd p oint eq u at ion , two p oint eq uat io n, p aralle l lines , p oint s o f int ers ection ,
dist ance b et ween t wo p oint s , chan ge o f o r ig in. Ex amp les fro m p rob lems in chemist ry,
cu rv e f it ting f or l eas t sq u ares met hod .
Eleme nts o f A lg eb ra ic a nd Trigo no metric Funct io ns
T he b inomial ex p ans io n, so me ex amp le from che mist r y, s in es , cos in es a nd

t angent s, t rigon o met ri c id ent it ies , p ola r coo rdina tes in t rig ono met ri c fun ct ion s .
Di ffere ntia l Ca lc ulus
T heory, ru l es of d if feren t iat ion , p owers , add ed a nd s ubt racted fu nct ions ,
co nst an ts, p ro ducts , q uo tient s , fun ct ions o f a fun ct ion , lo gar it h mic d if fe rent iat io n , an d
p a rametric f unct ions . A lg eb ra ic s imp l if icat ion , d iffere ntiat io n o f i mp l ic it fun ct i ons,
grap h ical s ig nif icanc e o f d ifferentiat io n , rat e o f cha nge o f s lop e, s u cc ess iv e
different ia ti on. Ex amp les re lat ed to max imally p op ulated rot ation a l en erg y l evels ,
Boh r's rad ius a nd mo st p rob ab le v e loc it y f ro m Max we ll’s d ist rib ut io n . Ex act an d
inex a ct d if feren t ia l with t h ei r ap p lica t ion to t her mod ynami c p rinc ip l es .
SECTI ON-C
Pa r tia l D i ffere ntia t io n
T he funda ment al t heo rem, g eo met rica l sign ifi can ce o f p artial different ia t ion,
sp ecial ca ses o f fund a ment a l t heo rem, s uccess ive p a rt ia l d if fe ren t iat io n . In teg ra l
t ran sforms (Fo u rier an d Lap la ce) . R edu ction for mu lae, ap p li ca tion t o ch emica l
p rob lems . Metho ds of Lag ran gian mu lt ip li ers, St erl ing ’s a pp rox imat ion , p ro b ab il it y
an d errors .
Integ ra l Ca lc ulus
Integra l t heo ry, ru les of in teg ra tion b etween l imits , s ig n if icance of ‘e’
ex p onent ia l eq u at ion s , meth ods o f in te g ra tion , v iz . al geb ra ic s imp li ficat ions ,
su b st itut io n , int eg rat io n b y p a rt s, int eg rat io n b y p art ia l fract ion s , coo rd inat e
t ran sforma tion (e.g . , ca rt es ian to sp herical p olar), cu rv e sket ch in g , in t egra l as area.
Illust ra tion o f a pp licat io n in ch emis tr y. E va lu ation of st and ard in teg ra ls us ed in
ch emistr y.
Di ffere ntia l Eq ua tio n
Simp l e d ifferent ia l eq ua tions , s ep a rab le v aria b les, ho mogen eou s eq uat ions ,
ex act eq uat io ns, l in ear eq uat io ns, eq uat io n of t h e f irst an d s eco n d o rder, p a rt ia l
different ia l eq u at ion , ap p li ca tion to p hys ico -chemica l p ro b le ms .
13
Boo ks Sug ges ted
1. Mat hema ti cal Prep arat ion for Ph ysi ca l Chemi st ry , F. Dan ie ls , McG ra w H ill .
2. Mat hema ti cal Prep a ra tion for G en era l P hys ics , J.B . Ma rian, R.C . Davids on
Sa under Co mp a ny.
3. Mat hema ti cal Meth ods fo r Sci en ce St udents , G . St ep hemen , ELBS.
4. Chemical T hermo d yna mics, R.C . Reid .
Or
M .Sc . Chemistry (Pre vio us) Se me ste r I

Introd uction to Pha rmacy and Pharmacology Pape r IVc
Time : 3 Hrs
No te: Eig ht q u est ions wi ll b e s et , t wo wi ll b e set fro m s ect io n A an d t hr ee fro m each

of t he se ct ion s B & C. T h e cand ida tes a re req uired t o at temp t five q uest ion s in all
select ing a tl eas t on e q ues t ion fro m each sect i on.
SECTI ON-A
Genera l : Int ro duct ion t o Ph ar mace uti ca l s cien ces , h ist ory and dev e lop men t o f
ch emot herap eut ic ag en ts , its b ra nch es , st and ards for d rug s , na ming of d rugs ,
t herap eutic i ndex , LD5 0 an d ED50 , P harmaceut ica l lit era tu re, o ff ic ia l b oo ks, rout es o f
drug ad min ist ra tion
Cel l S tructure & Cel lu la r Phy s io log y : Su b cel lu la r organ iz at ion , memb ran e
p rocess es , cell meta b olis m, cel l d iv is ion , Structure a nd fun ct ion of ep ith el ial
co nne ct ive , muscu la r and n erv o us t iss ues , Mu scl e con tract io n a nd p ro p ert ies , N erv e
i mp ulse ge nerat ion a nd trans mis s io n. Sk u ll & Ske leto n .
Res pira to ry Sy stem: Struct u re r esp irato ry v o lu mes a nd cap a cities , vent i la tion ,
co mp lian ce and res is ta nce , gas eou s ex cha n ge an d t ran sp o rt in b lood , nervous an d
ch emica l regu la t ions o f res p i rat ion . A cid-b as e b alance.
Rena l sy s te m: St ru ct u re of k idne y a nd u rinar y t ra ct ; n ep h orn tr an sp ort p rocesses
co ncentrat io n a nd dilut io n o f u ri ne , ren al co ntrol o f b ody flu ids , p la sma clearanc es,
Mat ura tion.
SECTI ON-B
Major Cat eg ories o f for mu lat ion s, Ph ys ica l p ro p erti es an d C hemi cal character ist i cs o f
drugs in f luen cing t h eir fo rmu lat io ns .
Metro logy : In tr oduct ion , u n it s of weight an d v olu me in b ot h i mp er ia l and met ric
syst em, Si mp le calculat ion s i nv o lv ed in p rep a ring solut io ns of so li ds in liq uids an d
l iq u id s b as ed on imp erial and met ric s yste ms , metho d o f a l legat io n.
14
Pr e fo rmula t io n c o nside ra t io ns : An a l yt ica l meth ods for cha ra ct eriza tion of d rugs ,
determinat io n of p Ka value, p H, s olub i li ty p rofi le, and eff ect o f t emp ep ra tu re,
so lu t ion and s o l id st at e st ab ilit y .
Emuls io ns : T yp es, ident ifi cat io n , a nd s elect io n o f emu lg en ts, p rep a ra tion an d
st ab il it y. E mp ha sis ma y b e g iv en o n off ic ia l p ro ducts .
Sus pensio ns a nd mix tures : P ract ica l con s ide ra tions , p rep ara tion of p rod uct s o f
different cat ego ries ev a lu at ion , st ab il it y, an d offic ia l sus p ens ions .
Se mi -So lid Do sag e Fo rms: A b rief d es cr ip t io n, p rep a rat io n o f o int ment s , cr ea ms
jell i es an d s up p osito ri es .
Aero so l Do s ag e For ms: Adv ant ages, fo r mu la tion an d sta nda rdiza tion .
SECTI ON-C
Pha rma co ki netics : A DME (Ab s orp tion, d is t rib ution , meta b olis m -Ph as e I a nd Pha se II
react ions , Ex cret io n) of d rug s, Imp orta nt p h arma cok in et ic p arameters-ap p arent v olu me
of d is tr ib u tion , b io ava ilab ilit y, clea ran ce.
Pha rma co dy nmics : El ementa ry idea ab out drug a ction , d rug targ ets,
neuro trans mit te rs , th e recep to r ro l e, Drug R ecep t or In t eract ions , t yp es of r ecep to rs -
ion chann el re cep t ors, G -p rot ein coup led recep t ors, ki nas e-l inked recep tors, io n
ch ann els a nd the ir c ont ro l , memb ran e b ound enzymes -act iv at ion /d eacti vat io n , des ign
of a gon is ts an d ant ago nis ts .
Pr inc iples o f to xico lo gy a nd trea tment o f po iso ning : In t rodu ctio n, T o x ic a gen ts,
T ox ic it y-acu t e, s ub a cut e a nd ch ron ic, d esc rip tive to x i cit y tests in a n i ma ls , G ene ra l
p rin cip les of man age ment of p oison ing , an t id ot es, T reat ment of h eav y meta l p oiso n in g
an d dru gs (b arb it urat es, b enz odiaz ep ines , sa licy lat es , morp hin e & morp h in e
derivat iv es, a lcoho l)
Boo ks Rec o mmende d:
1. G oo dman an d G il man’s Phar maco lo g ica l Ba si s of T h era p eu tics , McG ra w-H i ll .

2. B.G .Ka tz ung, Ba sic a nd C lin ical Pha rma co l ogy , L :a uge Med i cal Pu b lica tion ,
19 95 .
3. Introdu ct io n t o Pharmaco lo g y b y P.C. Dan d ya an d S.K. Kulk arni.
15
M.Sc. Che mis tr y (Pr ev io us ) Se me ste r II
M.Sc . Che mis try (Pr ev io us )

Ino rga nic C he mistry (Gener a l) Pa pe r V
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)

ca ndidat es a re req ui red t o a tt emp t fiv e q ues tions in a ll s el ect in g a t lea st on e
q u est io n fro m each s ect io n. A l l q uest io ns ca rry eq ua l marks.
S ECTION – A
Electro nic Sp ectra a nd Ma g netic Pr o per ties o f Tr a ns it io n Meta l Co mple xes -I
El ect ro ni c arran gemen ts o f mic ro sta tes, calcu lat io n of t he nu mb er o f

micro st ates in var io us elect ron ic ar ra nge me nt s, sp ect ro s co p ic t erm s ymb ols , v e cto r
diagrams t o ind icates cou p li ng of o rb it al an g ular momenta in p 2 , p 3 , d 2 con figurat ion s
an d s p in o rb it co up l in g for p 2 a rrange ment , sp ect ro sco p i c t erms , s p ect ral t erms of d 2
t o d 8 meta l ion s , dete rmin in g t he gr oun d s tat e terms -Hun d's ru l es, d eriva tion of th e
t erm s y mb ol fo r a clos ed su b she ll.
S ECTION – B
Electro nic Sp ectra a nd Ma g netic Pr o per ties o f Tr a ns it io n Meta l Co mple xes -I I
Interp ret at io n of electron ic s p ect ra, O rge l dia gra ms , T an ab e-Su gan o diagrams fo r
t ran sit ion meta l co mp lex es (d 1 -d 9 sta tes) , c alcu lat io ns of Dq , B a nd  p a rameters ,
ch arg e trans fer sp ect ra, s p ectros cop ic met ho d of a ssign ment o f ab s olu te co nfigu rat ion
in op tica ll y a ct ive met a l ch ela tes a nd their st ereo chemica l in for ma tio n, a noma lou s
mag net ic mo ment s , mag net ic e x ch ang e coup ling and s p in c ro sso ver.
Circula r Dichr o is m a nd Optica l Ro ta tor y Dis pers io n
Po lariz ed ligh t , funda ment al s ymmet ry req uire ment s , for op t ical act iv it y, int eract io n
of p olar iz ed l ig ht wit h op ti cal ly act iv e mat t er, op tica l ro ta tion, Cot to n ef fect ,
co nfigu rat io n of T ris -ch elated co mp lex es.
S ECTION - C
Meta l л- Co mplexe s
Met al ca rb on yls, s t ruct u re and b on ding , v ib r at io nal s p ectra o f meta l carb o nyls
for b onding and structu ral elucida t ion, imp ort ant react ions o f meta l carb ony ls ;
16
p rep a ration, b o ndin g, s t ruct u re a nd imp o rt ant react ions o f t ra nsit ion met al n itr os yl,
din itrog en a nd d iox yg en co mp lex es ; t ert iary p h osp hine as liga nd.
S ECTION - D
Meta l C l usters
High er b oran es, ca rb o ran es, met a l lo b oranes an d met allocarb oranes . Metal
ca rb o nyl a nd ha lid e clust ers , co mp o unds with meta l -meta l mu ltip l e b ond s.
Boo ks Sug ges ted
1. Adv anced In o rg ani c Ch emist ry, F. A. Cot ton a nd W ilkin s on , Jo hn Wi l ey.

2. Inorgan ic Che mis tr y, J .E . Hu hey , Harp er & R ow.
3. Inorgan ic E lect ro n ic S p ectros cop y, A.B .P. Le ver , E ls ev ie r.
4. Chemis tr y o f th e E le ment s , N. N. G reen wood an d A. Earnsh a w, Pe rga mon .
5. Introdu ct io n t o L ig and fields ; B .N . F ig g is , W iley , New York .
6. Modern As p ects of Ino rga nic Ch emis t r y; H.J . E meleus an d Sharp e.
7. Introdu ct io n t o L ig and F ield T heo ry; C.J .Ba llah yen , M cG raw H i ll, N ew Yo rk.
8. O rgano met all ic C hemist ry; R.C .Meh rot ra an d A .Singh , New A ge In t erna tio na l.
9. Con cep ts and Models of Ino rga n ic Ch emis try; B. Doug las , D .H .McDan iel a nd
J.J. Al ex a nder; J ohn W il ey.
10 . T he O rg ano meta ll ic Che mis tr y of th e T rans it io n Met als; R.H. Crab t ree, Joh n
Wil ey.

Phy sica l Che mis tr y (Genera l) Pa per V I
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)

ca ndidat es a re req uired to at temp t five q u est ions in a ll s elect in g at leas t one q u est io n
fro m each sectio n. A ll q ues t ions carr y eq u al marks .
SECTI ON-A
Q ua ntum Mecha nics-I
T he p o st ulates of q ua ntu m mechan ics , L in ear a nd Hermitian op era to rs.
Commu tat ion o f o p erat ors an d Un cert a int y Prin cip le . Sch rod ing er eq ua tion , e ig en
funct ion and eigen v alu es, free p articl e, Sch rodi nge r eq ua tion fo r a p article in a b ox ,
t he d egen erac y, p a rt ic le in a b ox wit h a fin it e b arr ier, S ch rod inge r eq ua tion fo r
l inear ha rmon ic os c il la to r a nd it s s olut ion , z ero p o int energ y, T u nnel ing P rob le m:
T un nel in g th roug h a recta ngu lar b arrier.
S ECTION – B
17
Q ua ntum Mecha nics-II
Energy levels a nd wa ve -fun ct ion s of R ig id rot at or . H yd rog en a to m:

Comp let e so lut ion (s ep a ra tion o f v ariab les in s p herica l p o lar co ord in at es a nd it s
so lu t ion) . Radia l d ist rib ut ions . An gu lar mo mentu m an d its d irect ion a l q ua nt iza tion,
Ang ula r mo men tu m op era tors, co mmut at ion relation , sha p e of at omi c o rb it a ls u p t o d -
lev e l and t hei r d is cuss ion .
SECTION – C
Basics of Polymers and Polymerization
Revision of Basic concepts, Kinetics of Polymerization: Mechanism and Kinetics of

chain growth polymerization: free-radical, cationic, anionic and coordination polymerization.
Mechanism and Kinetics of step-growth polymerization. Comparison between step-growth and
chain polymerization. Molecular mass of polymers: Significance of average molecular mass.
Poly-dispersity, Molecular mass distribution curves. Determination of molecular mass by
osmometry and viscosity methods. Electrically conducting polymers, Fire resistant polymers,
Liquid crystal polymers.
SECTI ON-D
Nuclear and Radiochemistry
Nuc lear st ab ilit y a nd b in d ing en erg y. Ma ss and b ind ing en erg y, Nuc lear fiss ion an d
nu clear fus ion , f is s ion cross s ect io n , ch a in f is s ion , f is s ion p ro duct and fis s io n y ie ld .
Intera ct ion o f nu clear ra d iat ion with mat ter , Det ecto rs (Prop o rt ion al , G eig er -Mu l le r
an d Scint il lati on coun te rs) an d th eir p rin cip les . Un it s for meas uring rad iat ion
ab sorb ed , ra d iation do s i met r y.
Ra diotracer techn iq u e, Act iva t ion a nal ys is, iso top e d ilut ion t ech n iq ue,
Rad io chro mat ograp h y, ra d io met ri c t it rati ons , N eut ro n a b so rp t io met ry. S o me
ap p lica tions
Boo ks Sug ges ted
1. Introdu ct io n t o Q uan tum Che mis tr y, A . K. Ch an dra , T at a McG raw H il l.

2. Q ua ntu m Ch emist r y, I.M . L ev ine, Prent i ce H a ll .
3. Es sen t ials of Nuc lear C hemist ry, 4 t h Ed it io n (1 995 ), H .J . Arn ikar, Wi le y
Ea stern , N ew Delh i.
4. Nuc lear & R adi och emis t r y, 3 rd Edit ion (1 981 ), G . Frid land er, J .W. Kenn ed y, E .
S. Ma cia s, a nd J. M . M i ller, Jo hn Wi l ey, N e w Yo rk.
5. Introdu ct io n t o Nu cl ea r Chemist ry, B . C . Ha rve y Prent ice-Ha l l (1 969 ).
6. Po lymer Chemist ry , Bil lma yer
7. Po lymer Chemist ry , G owar ik ar
8. Prin cip les of Pol ymerizat io n , G er og e O d ia n.
9. Q ua ntu m Ch emist r y, B. K. S en , Ka l yan i Pub l ishe rs
10 . Q ua ntu m Ch emist r y, R. Pra sad , New Ag e Int erna tiona l.
18

Orga nic C he mis try (Gene ra l) Pa pe r V II
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)
No te: Eight q ues tions wi ll b e set , t wo q ues tions f ro m ea ch of t h e sect ions A , B, C &
D. T h e cand id ates are req uir ed t o a tt emp t fiv e q uest io ns in a ll , sel ect ing at le ast
on e q ues t ion fro m ea ch s ect ion . All q ues ti on s carry eq u al marks .
S ECTION – A
Aro ma tic Ele ctro phil ic S ubst it utio n
T heoret ica l t rea t men t o f aromat ic s ub s titu t ion react io ns, st ructu re -rea ct iv it y
rela tions h ip in mo no s ub s titu ted b enz ene r in g , or ien ta tion in o th er ring s yst em, en erg y
p rofile d iagram, V i ls mei r-Haak rea ct ion , Reimer-T iema nn react ion , Bis ch ler -
Nap ieralsk i r ea ct ion , P ech a man n react ion , Hou b en -H oes ch reaction , Fr ies
rearra ngement
Nuc le o phi lic Aro ma tic Subs titu tio n
Mechanis m o f Nuc leo p hi li c sub st it utio n in a roma ti c s ys t ems via d iazo niu m ions , b y
ad dit io n-el iminat io n an d el imina t ion-add it io n machanis m ( invo lv ing a rynes ); von -
Richt er r earra nge ment , Sommelet- Haus er an d S teven s rea rr ang ement s.
G en eral as p ects o f g en era tion , st ructu re, s ta b i lit y an d rea ct iv it y o f ar yn es
SECTI ON-B
Al ipha tic E le ctrophil ic Subst it utio n
Bimolecular mec hanis ms - S E 2 and S E i . T he S E 1 me cha nis m, ele ct ro p hi lic

su b st itut io n a cco mp an ied b y do ub le b ond s h ifts . E ff ect o f s ub s trat es , l ea vin g g ro up
an d the s o lv ent p olarit y o n the r ea ct iv it y.
Neig hb o uring Gro up Pa rtic ip a tio n a nd Ca r boca tio n Rea rra ngeme nts
Anch ime ri c a ss is tan ce, n eig hb o uring gro up p articip at io n b y no n -b ondi ng el ect ro ns,
sig ma an d -b on ds, cla ssi ca l and non -c la ssi ca l carb ocatio n , carb ocat ion s
rearra ngement s, mig ra to ry ap titu des , Wa gn er Meerwein rearran gement, p in co l
p inacolon e r ea rrange ment , D e mja nove rea rrang emen t , T if fen eau -D e mjan ov e r ing
ex pan sion, a ldeh yde -keto n e rearrang emen t , dien one-p h enol r ea rrange ment a nd t rans -
an nular rearra ng ement s .
19
S ECTION – C
Fr ee Radica ls
G en eral as p ects of genera t ion, s tru ct ur e, s ta bil it y an d rea ctiv it y of free ra d ica ls, t yp es
of free rad ical r eactions , ha logenat io n in cl ud ing a l ly lic h a logen at ion (NB S), au to -
ox ida tion, de co mp osit ion of azo comp o und s an d p ero x id es, co up l in g o f alk yn es ,
ho mo lyt ic aro mat ic s ub st itut ion , Sa ndme yer r eaction an d Huns d ie cke r react io n .
Additio n to C-C Mult ip le Bo nd
Mechanis m of ad d it ion o f h yd ro gen ha lid e, H 2 O , ha log ens , HO X a nd mercuric sa lt t o

alken es and alk yn es . H yd rob ora tion , fo rma tion o f C -C b o nds via organ ob o ran es,
hyd ro b orat ion o f acet ylen es , nu cleo p hi li c ad d it io n t o a lken es.
SECTI ON-D
Additio n to Ca rbo n-He tero Ato ms Mul tip le B o nds
Hyd rat ion a nd Add it ion of A lcoho ls to A ld eh yd es , Keto nes an d Acids . Add it ion -
El iminat ion R eact ions o f Keton es and Ald eh yd es, Rea ct iv it y o f carb ony l comp ound s
t owards Add it ion .
Mann ich React io n , lith iu m a lu min iu m h yd rid e , red uct io n o f ca rb onyl co mp oun ds,
acid s , es te rs, n it ri les , ad dit ions o f G rign ard reagent s . Refo r mats ky react io n , W it ti g
react ion , Cla isen cond ens ation , D ieck man r eaction , A ldo l cond ens at ion , Knoe ven agal
co ndensa t ion, P erk in react ion , Ca nnizza ro react ion , Be nzo in co nd en sat ion , Rob in son -
Mann ich rea ct ion , Est er h ydro lys is , a mino lys is o f es t ers , a mid e h ydro l ys is .
Boo ks Sug ges ted
1. Ad van ced O rgan ic Ch emis t r y R eact ions , Mech anism and St ru ctu re , Jerry Mar ch,
J ohn W i ley.
2. Ad van ced O rgan ic Che mis tr y, F. A . Carey an d R. J. Su ndb erg , P lenu m.
3. A G uid e Boo k to Mec hanis m in O rgan ic Ch emis tr y, P eter S yk es , L ong ma n.
4. S truct ure and Me cha nis m in O rga nic C hemist ry, C. K. In g ol d, Corn ell
Un iv ers it y Press .
5. O rga nic Ch emist r y, R . T . Mo rrison an d R . N . Bo yd, Prent i ce -Hal l.
6. Mo dern O rga nic React ions , H. O . Hou se, Ben jamin .
7. P rin cip l es o f O rg an ic S ynt h es is , R. O . C. Norma n a nd J . M. Cox on , Bla ck i e
Acade mic & Pro fess iona l.
8. R eaction Me cha nis m i n O rgan ic Chemis t r y, S. M. Mu kherj i a nd S. P. Singh,
Ma cmillan .
20

App lica tio ns o f Co mp ute r in C he mistry Pape r V II I
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)
No te: Eight q u est io ns wil l b e s et, t wo f ro m s ect io n A and t hre e fro m ea ch of th e
sect ions B & C. T h e can d id at es ar e req uired t o a tt emp t fiv e q ues t ions in al l
sel ect ing at lea st on e q ues tion f ro m ea ch section .
SECT ION- A
El emen ta ry Asp ect s o f co mp ut er , me mo ry size/a rch it ect u re. Binar y, o ct al &

hex ad eci mal nu mb er sys t e ms. Us ing Int ern et , wo rd p ro ces si ng p ack age; G rap h ics
Pa cka ge and visua lizat ion . Intr odu ct ion t o Op era t ing s ys te m (UN IX , Wind o ws ) an d
p rogramming la ngua ge. A lgo rith m, F lo w ch a rt s. Wr it in g s imp l e p rograms , conv ert in g
a flo w chart in to a p ro gra m. Us ing g ra p hics packag e p lo tt ing (a) y = x , x 2 , sin (x ),
t an(x ) (b ) wavefu nct io ns fo r s , p , and d – orb itals .
SECTI ON-B
Numerica l Met ho d s: Ro ot s o f P o lyno mials , Solut io n o f L in ear s imultan eou s

eq uat io ns, mat rix mu lt ip lica tion an d in v ers ion . Nu meri ca l d i ff er ent ia t ion an d
integ ration . Sta tist ica l t rea tment of da ta , var ia nce a nd co rrelat ions , linea r reg ress io n,
Curve f it ti ng.
S ECTION – C
Using Ch emDra w. Writ ing p rog rams fo r va n der Waals eq ua tion, p H t it ra tion ,
kin et i cs, ra d ioact ive de cay , evaluat ion o f la tt ic e en erg y an d io n ic ra d ii fro m
ex p erimenta l dat a. El ementa ry st ru ct ura l fea tu res s uch a s b ond lengt hs , b on d a ngles ,
dih ed ra l a ng les et c. of mo lecul es ex t ra ct ed fro m a da tabas e s uch as C amb ridg e
da tab as e.
Boo ks Sug ges ted

1 . Introdu ct io n t o Comp u ter S ci enc e, P. K. Sinh a
2 . Let Us C, Yas h wan t Kan etk er
3 . Comp uta tiona l Che mis t r y, A .C. Nor ris.
4 . Programming in Fo rt ran 9 0 a nd 95 , V. Ra jaraman .
21
M.Sc. Che mis tr y (Prev io us) Se mes te r I & I I

Ino rga nic C he mis tr y P ra ctica l (Gene ra l) P a pe r IX
Time: 6 Hr s
(Two ses sio ns )
Ma x. Ma rks : 8 0 +20(I A)
I. Q ua lita tiv e a na ly s is : 3 0 Ma rks
T ot al five radi cals to b e given co nt a in in g t wo l ess co mmon meta l io ns , on e

inso lub le an d t wo ac id rad ica ls.
Less commo n metal ion s - W ,T l,Mo,Se,T i,Z r,T h ,V ,U ,Ce ,Be.(t wo met al ions in
ca tion ic/ an ion ic fo rms )
Insol ub les : Ha lid es ( AgCl , AgBr , Ag I); Sulp ha tes (Pb SO 4 ,BaSO 4 ) an d
Ox ides(Al 2 O 3 ,Cr 2 O 3 ,SnO 2 , T iO 2 , SiO 2 )
II Q ua ntita tiv e Ana ly sis 1 5 Ma rks
Sep arat ion of th e meta l ions and det er min at ion of an y on e o f t h em u s in g

vo lu met r ic/g rav imet ric met hod s .
Cu-Ni, Cu-Z n , Cu -A l, Ca-B a, Fe -Mg, F e-N i etc.
III Pr epara tio ns: 1 0 Ma rks
Prep a rat ion of s elect ed in o rg ani c co mp oun ds and t heir sp ect ro s cop ic st ud ies .
1. Hg[Co(SCN) 4 ]
2. Ni (dmg ) 2
3. [Cu(NH 3 ) 4 ]S O 4 H 2 O
4. Pruss ia n B lu e a nd T urnb u ll 's B lue .
5. Na[Cr(NH 3 ) 2 (SCN) 4 ]
6. Mn(aca c) 3
7. [N i(N H 3 ) 6 ]C l 2
8. VO (aca c) 2
IV La b. Rec ord 1 5 Ma r ks
V iva -voce 1 0 Ma r ks
Boo ks Sug ges ted

22
1 . A T ex t Boo k o f Ma cro a nd Semi-micro Q ua ntita tive Ana lys is , A .I.Vo g el, O ri ent
Lon gman .
2 . A Vogel 's T ex t Bo ok of Q ua ntit ative Inor gan ic Ana lys is , J . Ba ss ett , R.C . Den n ey,
G .B. Ja ff ery a nd J . M enaha m, Lon g man, Lon d on.
3 . Synth es is an d Ch aract er iz ation of Ino rga nic Co mp oun ds, W.B. J o ll y, P ren t ice Hal l,
Eng le wood .
4 . Synth es is and Ph ys ical St ud ies of Ino rga nic Comp ound s, C.F. B el l, P erga mo n
Press
5 . Inorgan ic Prep a rat ions ; W.G . Pa lme r.
M.Sc . Che mis try (P rev io us) Se mester I & I I

Phy sica l C he mis try Pr actica l Pa per X
Time: 6 Hr s
(Two ses sio ns )
Ma x Ma rks : 8 0 +20(I A)
I Exp eri ments
Refra c to me tr y
[1 ] Det er mine t he re fract iv e ind ex of s imp l e organi c liq u ids l ik e meth yl acet at e, et h y l
acet at e, met han ol , et han o l, n-h ex a ne, ch loro form.
[2 ] Determin e the refract iv it y and mo lar refra ct iv it y of s o me o rga ni c l iq uid s l ik e

met h yl aceta te, eth yl acet at e, met ha no l , et han ol, n -h ex a ne, ch lo ro fo r m.
[3 ] Det er mine t h e mo lar refract iv it ies f or CH 2 , C, H a nd C l.
[4 ] Stu dy the va riat io n of r efract iv e in dex with co n cen trat ion fo r KC l solut io n an d
t hereaft er det er min e th e u nk no wn con cent ra ti on of g ive n KC l so lut ion.
Po la rimetry
[5 ] (a) S tud y t he va riat io n o f ang le of o p ti ca l ro ta tio n wit h the con cent ra tion of an y
op tical ly a ctiv e s ub st an ce (s ucros e o r glu cos e) an d t herea ft er det ermine th e u nkn o wn
co ncentrat io n o f th e sa me s ub s ta nce in g iv en solut io n .
(b ) Det ermine t he sp eci fic and mo l ecu la r rot at io n o f suc ros e or gl uco s e at nu mb er o f
co ncentrat io ns.
[6 ] St udy t he k in et ics of invers ion o f cane -s u gar (su cros e) in p res enc e of an ac id .
Po te ntio me try
[7 ] Det er mine t h e st an dard elect ro d e p ot ent ial of Cu a nd Zn.
[8 ] Det ermine the st ren gt h o f a g iven so lu tion o f ferro us a mmon iu m s u lp hat e b y

p o ten tiomet ri c t it rat ion wit h K 2 Cr 2 O 7 s o lu t io n.
23
[9 ] St udy t he p recip ita t ion t it rat io n b et ween KC l a nd AgNO 3 p otent iometr ical ly.
[1 0 ] Det ermine the st rengt h of io d id e, b ro mid e and ch lor id e in a mix tu re b y

p o ten tiomet ri c t it rat ion wit h s i lv er n itrat e.
Co nd ucto metry
[1 1 ] Det er mine t he st ren gth of s trong acid b y c ond uct o met ric t itrat ion with st ron g
b a se.
[1 2 ] Det er min e th e s t reng th of weak ac id b y condu ct o met ric t itrat io n with s trong b a se.
[1 3 ] Determin e t he s tr eng th of s tro ng a cid an d weak acid in a mix tu re b y

co ndu cto met ric t itratio n with s trong b a se.
[1 4 ] Stu dy p rec ip ita tion t it ration b et ween KC l a nd AgNO 3 co nducto met r ica lly .
Det ermin e t he s treng th o f g iv en so lut io n o f AgNO 3 .
[1 5 ] Det er min e th e b asicit y o f mono- , d i- and t ri-b asic ac ids cond u ct o met ri ca ll y.
[1 6 ] Det ermin e so lub i lit y a nd solub il it y p ro d uct of sp aring ly so lub le s a lt s like Pb SO 4 ,

BaSO 4 .
pH-metr y
[1 7 ] Det er min e th e s t reng th of s tron g a cid b y p H-metr ic t it ra ti on wit h st ro n g b as e.
[1 8 ] Det er min e th e s t reng th of weak ac id b y p H -met ri c t it rat io n wit h s t rong b ase.
[1 9 ] Det er min e th e d is so c iat ion con st ant o f acet ic acid us ing p H -met er .
Che mica l Ki ne tics
[2 0 ] St udy t h e h yd ro lys is o f met h yl a cet at e in p res en ce of h yd ro ch lo ric ac id.
[2 1 ] St udy sa p on if ica tio n of et h yl a cetat e b y s od ium h yd rox ide s olu tio n us ing sa me
in it ial co n cent rat io n o f b ot h th e rea ct ant s.
[2 2 ] St udy sa p onifica t ion o f et h yl a cet at e b y s od iu m h yd rox ide so lut io n t ak ing th e

in it ial co n cent rat io n o f es t er and b a se t o b e d if fe rent .
V is co s ity
[2 3 ] Det ermin e th e vis cos it y of met h yl aceta te and et h yl ac et ate us in g O st wald

visc omet er.
[2 4 ] St udy t he varia t ion of v iscos it y with co ncent rat io n fo r a gl ycero l so lut io n u sin g
O st wald v is co mete r and t h er ea ft er det ermine th e con cent ra tion of u nkno wn so lut ion o f
gl ycero l.
[2 5 ] Det er min at ion o f mo la r mass o f a p ol ymer .

24
Dis tribut io n La w
[2 6 ] Det er min e d is tr ib ution coeffici ent o f ammon ia b et ween ch lor ofo rm and wat er.
[2 7 ] Det ermine th e fo rmu la o f th e co mp lex formed b etween cop p er (II) io n an d

ammo n ia u s ing d istr ib ut ion metho d .
Adsor ptio n
[2 8 ] Ver ify th e Freund l ich and La ng mu ir ad s orp t ion iso the rms f or ad sorp t io n o f acet i c
acid /ox alic ac id on a ct iva ted charco a l.
No te : Any ex p erimen t ca n b e int ro duc ed o r deleted in the p ractica l class o n t he b a sis

of a vai la b ilit y of ins tru men ts /ch emi cals .
Exp eri ment : 55 Marks

Lab Re co rd : 15 ma rks
V iva -voce : 1 0 ma r ks
Boo ks Sug ges ted
1. Pract ica l P h ys ica l Che mis tr y, A.M. Ja mes and F.E . Pr ichard , L ong ma n.
2. Find ley ’s Pract ical P hys i ca l Che mist ry , B.P. Lav it t, Long ma n.
3. Pract ica l P h ys ica l Che mis tr y, S .R. Pa lit and S. K. D e, Scien ce.
4. Exp erimen ta l Ph ys ical Ch emis tr y, R .C. Da s a nd B . B eh era , T at a McG raw H i l l.
5. Exp erimen ts in Phys ical Ch emis tr y, D.P . Sh o ema ker
6. Exp erimen ts in Phys ical Ch emis tr y, D. V. Ja h ag irdha r.
7. Senio r Pra ct ical Ph ys i cal Chemist ry b y B.D . Kho s la, V . G a rg an d A . G ulat i .
8. Adv anced Pra ct ica l Ph ys ica l Ch emist ry, J .B. Yad av, G o el Pu b lish in g Ho use .
M.Sc . Che mis try (P rev io us) Se mester I & I I

Orga nic C he mis tr y P rac tica l XI
Time: 6 Hr s
(Two ses sio ns )
Ma x. Ma rks : 8 0 +20(I A)
I. Pu rifi cat io n of or gan ic co mp ou nds inv o lv ing f ractio na l cr ys ta l l iza tion,

fract iona l d ist illa t ion, s t eam dis t i llat ion , s ub l ima tion and ex tract ion.
Syste mat ic id en t ifi cat ion of p u re orga n ic co mp ou nds : sep aration an d

ident i ficat io n o f s i mp le b ina ry mix tu res h avi ng acid ic, b asic and neut ra l co mp o nen ts.
Prep a rat ion of t hei r d erivat iv es .
25
II. Prep a rat ion of organi c co mp ound s inv o lv in g t wo sta ges . Est ima t ion of p h eno l
an d a nilin e. Det erminat io n o f th e mo lecu lar weight o f an acid b y t itrat io n a nd b y th e
si lver s a lt met hod.
III. Exp eri ment Ma rks : 5 5
Lab r ecor d & V iv a -vo ce Ma rks : 1 5+1 0
Boo ks Sug ges ted
1. A Hand b o ok of O rg anic Anal ys is -Q ua lita t iv e and Q u ant it at iv e b y H .T . Clarke,

an d rev is ed b y B .Hayn ee, E d ward A rno ld, Lo ndo n 1 975 .
2. Vog el's T ex t Bo ok o f P ract i ca l O rgan ic C hemist ry b y B .S. Fu rh en et. a l.,
Lon gman -G roup Lt d .
3. Syste mat ic Q ualit at iv e O rgan ic Ana l ys is b y H . M id d leto n , Ed ward Arno ld
(Pub lis h ers) L imited , Lon don 1 9 59 .
4. El emen ta ry Pract ical O rgan ic Che mis tr y b y Art hur I. Vog el, EX CBS Pu b lis hers
an d Dis t r ib u tors.
5. Exp erimen ts in O rga nic C h emist ry b y Lo u is , F.Fies er, D . C. Hea th an d Comp an y
Bos to n, 1 9 55 .
26
M.Sc . Che mis try (Fi na l) Se mester I II
M.Sc. Che mis try (Fi na l)

I no rg a nic C he mistr y (Genera l) Pa per XI I
Ti me: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)
No te: Eight q uestio n s wil l b e set, t wo from s ect ion - A a nd th re e eac h fro m s ect io ns B
& C. T he can did at es are req uired to at t emp t fiv e q u est ions in a ll se lect ing at
leas t one q ues tion fro m each sectio n. A l l q u est ions ca rr y eq u al marks.
S ECTION - A
Hy dro sp her e
Chemical comp os ition of wat er b o dies - la k es, s t rea ms , rivers and wet land s
et c., H yd ro log i ca l cyc le. Wa ter p ollu tio n – ino rga ni c, organ ic , p es ti cide, a gr icu lt u ral,
indus tr ia l a nd s ewag e, d et ergen ts , o il sp i lls and o il p ol luta nt s. Wa ter q u alit y
p a rameters – diss o lv ed ox ygen , b ioch emica l ox ygen deman d , s o li ds , met als, co nt ent o f
ch lor ide, s u lp hat e, p hos p ha te, n itrate a nd micro -organ is ms . Wat er q u alit y st anda rd s.
At mo sphere
Chemica l co mp o siti on of at mo sp h ere – pa rt icl es , io ns and ra di cals and th ei r
forma tion , Che mica l and p ho tochemi ca l r eactions in at mos p here, s mog f or ma tion ,
ox ides o f N , C, S a nd their ef fe ct, p ollut io n b y ch e mica ls, p et ro le um, mine rals ,
ch lorof lu oro h yd rocarb ons . G reen h ous e effect , acid rain , air p ol lu t ion con tro ls an d
t hei r ch emis t r y.
SE CTION - B
Meta l Io ns in B io lo g ica l Sy stems
Es sentia l a nd tra c e me ta ls .
Na + /K + P u mp
Ro le o f me ta ls io ns in bio lo g ica l p roc esses
Tra nsp ort a nd Sto rag e o f Dio xy ge n

27
Heme p rot eins and ox yg en u p ta ke, s tructu re and fu n ct io n o f h emo glo b in , myog lob in,
hemo cyan ins an d h emer yt hrin , mo del s ynt het ic comp l ex es o f i ro n a nd co b alt.
Electro n Tra ns fer i n B io lo g ica l Sy s te ms
St ru ctu re and fun ct ion of meta llop rot eins in e lectron trans p ort p rocess es -
cytoch romes an d iron -su lp hu r p rote in s , s ynt h et ic mo d els.
Po la rogra phy
G en eral p ri ncip les , d iffus io n con t ro l led curre nt , Ilk ov i c eq uat io n ( wit hou t
p roof), Hal f- wave p ot ent ia ls , o ver p ot ent ial, t h eor ies o f h yd ro g en o v ervo lt age,
(T afel's th eo r y / Reco mb in at ion t h eo ry and Vol mer , Erd y & G ru ss th eo r y / th eor y o f
slo w d isch arg e of ions ).
S ECTION - C
V ibra tio na l S pectro sco py
Sy mmetr y a nd s ha p es , a nd no . of IR mod es AB 2 , AB 3 , AB 4 , AB 5 a nd A B 6
(G rou p T h eoret ical t reatment ) mo d e o f b o ndi ng of a mb id ent at e ligan ds and d iketo nat o
co mp lex es , ap p lica t ion of r eso nance Raman s p ectroscop y p a rt icu la rl y fo r t he st ud y o f
active s it es of meta l lop rote in s.
Mö ss ba uer Spe ctro sco py
Bas ic p rincip les, s p ectra l p a rameters an d s pectru m d is p lay. Ap p li ca tion of th e

t ech n iq ue to th e s tu dies o f (1 ) b onding an d st ruct u res o f Fe + 2 and Fe + 3 comp ound s
inclu di ng th os e o f int ermed iate s p in , (2 ) S n + 2 a nd Sn + 4 co mp ou nds – nat ure o f M-L
b o nd, coo rd inat io n n u mb er, s tru ct ur e and (3 ) d et ect io n of ox ida tion st at e.
Pho to e le ctro n Spectro s co py
Bas ic p rin cip les; p hot o-elect ri c eff ect , ion iza tion p rocess , Ko op ma n’s t h eo re m.
Ph oto el ect ro n s p ect ra of s i mp le mo lecu les , E SCA, ch e mica l in fo r mat io n f ro m ES CA.
Boo ks Sug ges ted
1 . Prin cip les o f B io inor gan ic Chemist ry : S.J . Lip p a rd and J.M. Berg , Un iv ers it y
Scien ce Boo ks .
2 . T he Inorga n ic Ch emis tr y o f B io log ica l P roc es s; M.N . Huges; J ohn W il ey & Sons .
3 . Env iron menta l Che mis tr y; S. E. Mana han ; Lewis Pub lish er.
4 . Env iron menta l Che mis tr y; A . K.D e, Wi le y Ea s tern .
5 . Ph ys ica l meth ods in Chemist ry; R.S .Drago ; S aun ders, P h ilad elp hia .
6 . T ex t Boo k o f Q uan tita tive In organ ic Ana l ys is ; A.I. Vog el ELBS ; Lon don .
7 . Env iron menta l Po l lut ion Ana lys is ; S.M. Kho p kar, W iley Eas tern .
8 . Fu ndament als o f Mo le cu lar S p ectros cop y; C N Banw ell; M cG raw H il l.
9 . Env iron menta l Che mis tr y; S. K. Ban erj i; Pren t ice - Ha ll .
28
M.Sc. Che mis tr y Semes te r I II

Phy sica l C he mis tr y (Gene ra l) Pa p er XII I
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)
No te: Eigh t q ues tions wi ll b e s et , two fro m s ect ion A and t hree f ro m ea ch of th e
sect ions B & C. T he candida tes a re req u ire d t o att emp t fiv e q uestio n s in a ll
sel ect ing at lea st on e q ues tion f ro m ea ch se ction .
S ECTION – A
Uni fy ing Pr inc ip les
El ect ro magn et i c ra diatio n , Int eract ion o f electro mag net ic rad iat io n wit h ma tt er -
ab sorp t ion , emiss ion , t rans mis s ion , r ef lect io n , ref ra ct ion , d isp ers ion , p olar iz at ion an d
scat tering. Un certa int y re lat ion and na tural l in e widt h and line b roa den ing , trans it ion
p robab ilit ies , r es u lt s of th e t ime d ep en den t p ert urb at ion t heory , trans it io n mo ment ,
select ion ru l e, int ens it y o f s p ectra l l in es, Born -O p p enh ei mer ap p ro x ima tion ,
rota tiona l, v ib rat io na l and el ect ron ic en erg y l eve ls .
Mic ro wa ve Spectro sco py
T he ro ta tion o f mo l ecu l es, rota t iona l s p ec tra o f r ig id d ia tomi c mo le cu les ,
intens it ies of rot ation a l sp ect ra l l ines , iso t o p ic effect , non - rig id r ot ato r, s p ect ra o f
p o lya to mic l in ear mo l ecu les and s ymmet ri c t o p mo lecu les .
In fra red Sp ectro s co py
T he vib rating d iat omic mo lecu le , f or ce co ns ta nt, z ero p o int energ y, s imp l e
ha rmon ic v ib ra to r, an har mon icit y, Mors e p ot en tia l, o verto nes , h ot b an ds, diat omi c
vib rat ing rot ato rs , P,Q ,R b ranch es , vib ra tion of p o lyat o mic mo lecu les , n orma l mode o f
vib rat ion s . Fo uri er t ra nsfo r m s p ect roscop y .
Ra ma n Sp ectro s co py
Class ical and q uan tu m theori es , p ure ro t at io nal Rama n sp ect ra of l in ea r
mo lecu les , vib rat ion a l Ra ma n sp ectra, mu tua l ex clu si on p rinc ip l e, p ola rizat ion of th e
l igh t and Ra man effect , dep o la rizat ion of Rama n lines , te chn iq u e.
S ECTION – B
Nuc le a r Ma g ne tic Reso na nce Spec tro sco py

Bas ic p rin cip les of NMR , theor y o f n ucl ea r ma gnet ic r es ona nce, sp in la tt ic e
rela x at io n, s p in -s p in relax at ion, ex p eriment a l t ech n iq ues ch emica l s h ift , th e  -sca le
29
of ch emical sh ift , t he orig in o f sh ieldi ng co n st ant , p a tt ern of cou p l ing , o r ig in of sp in -

sp in coup l in g , t he nuc lear o v erh aus er e ff ect .
Electro n Sp in Res o na nce Spe ctro sco py

Bas ic p rin cip l es of ES R, ex p eri ment a l t echn iq ue, t h e g -va lue h yp erf in e
st ru ct ure, app li cat io ns of ESR s p ectroscop y t o t he s tu d y o f free rad icals an d fas t
react ions , sp in dens it i es a nd Mc Co nne ll rela t ion sh ip .
Nuc le a r Q uadr upo le Res o na nce Spectro scpy

Bas ic p rin cip les of NQ R, ex p erimen ta l t echn iq ues, Zee ma n eff ect in NQ R
sp ect ra , q u adrup ole in tera ct ion s in mo l ecu les , ap p lica t ions .
S ECTION – C
X-ray Cry sta llo g ra phy
Sy mmetr y e le ment s in cryst a ls , crit eria for determin in g u n it cell of lat t ice,
st ereog ra p hic p ro ject ions , p oint g r oup s ( il lu st ra tion o f R, R -b ar, R m, R/ m, R-b ar/m
p o int g rou p s on l y) , mil le r in d ices fo r p la nes , sp ace latt i ces , sp a ce g roup s P 1 , Pb a r1 ,
P2 , P21 , Pm, Pc, Cc, C2 , Cm, C2 /m. D ef ects in cr ys tal . D er iv ation o f eq uil ib riu m
co ncentrat io n o f Sch ot tk y a nd F renk e l d ef ect s .
Produ ct ion o f X -ra ys, X-ray sp ect ra , ab s orp tion ed g es , X-ray fi lters, R ecip ro ca l
latt i ce con cep t and its i mp ortan ce, Defin it io n of Recip roca l lat ti ce vecto r (d erivat io n
ex clud ed ). Int erp la nar sp acing us ing r ecip ro ca l lat t ice con cep t for cub ic, t et ra gon al,
orth orh o mb ic an d hex ag onal cr ys tal s y st ems. Eq u iv alence of B rag g’s an d Lau e
co nd iti on. St ruct u re fact or ca lcu la t ions fo r p ri mit iv e, b as e -cen te red , b od y-cent ered
an d face cent ered un it ce lls . Relat io n of s truct ur e fact or to elect ro n d ens it y an d
intens it ies (der ivat io n ex clud ed). Data col lec tion an d d at a red uct io n , Pha se p rob lem –
Pa tt erson met hod an d H eavy -a tom met ho d, r ef in emen t of st ru ctu re b y su ccess ive a nd
differen ce fo u rier s y nt hes is . Cor rectn ess o f a st ru cture (D isc rep ancy ind ex ).
El ect ro n d if fract io n : Bas ics, Meas ur ement t echn iq ue, C omp aris on wit h X -ra y
diffra ct ion t ech n iq ue. Ap p licat ion s in s tr uct u re d et erminat ion .
Neu tron d iffra ct ion : Bas ics , mea su remen t t ech niq ues , Ap p licat io ns an d
co mp aris on wit h X -ra y d i ffra ct ion t ech n iq ue.
Boo ks Sug ges ted

1. Fu ndament als o f Mo le cu lar S p ectros cop y, C .N. Ba nwel l , T at a McG ra w H i ll.
2. Modern Sp ect ro sco p y, J .M . Ho llas, Joh n W i le y.
3. Bas ic P rin cip les of Sp ect ros cop y, R.Ch ang , McG ra w H i ll .
4. Introdu ct io n t o Mo le cu lar Sp ect ro s co p y, G .M . Barro w, McG ra w H il l.
5. Ph ys ica l Meth od in Che mis tr y, R.S. D rago , Sau nders Co l leg e.
6. El emen ta ry C ryst al log rap hy, L. Aza rof f.
30
7. St ru ctu re D eter min at ion b y X-ra y Crys ta llog r ap hy , M. La dd and R. Pal mer
8. X-Ray Struct u re D et erminat io n : A Pract ica l G u ide, 2 nd Edit ion b y G eorg e H.
St out a nd L yle H . J ensen
9. Es sen t ials of Cr yst a l lo gra p hy, M cKie & McKi e, B lack well Sci en t ifi c
Pu b lica tio ns , 1 98 6
10 . Han db oo k of X -ra ys, E mmett a nd F. Kae lb se, McG raw H i ll .

Orga nic C he mis tr y (Gene ra l) Pa p er XIV
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)
No te: Eight q ues tions wi ll b e s et , t wo s fro m each of th e s ect ions A, B, C & D. T h e

ca ndidat es a re req uired t o at temp t five q uest io ns in all s elect ing at l eas t one q u est io n
fro m each sectio n. A ll q ues t ions carr y eq u al marks
S ECTION - A
Ul tra v io le t a nd V is ible Sp ectro sco py
Vario us elect ro n i c t ra nsit ion s (1 85 -80 0 n m), Beer-La mb ert law, eff ect o f s o lven t on
el ect ron ic trans it io ns , u lt ra vio let b an ds fo r carb on yl co mp oun ds, uns atu rat ed carb onyl
co mp oun ds, d ien es, con ju gat ed p olyen es . Fies er -Wo od wa rd ru l es for con jug ated
dienes a nd carb ony l co mp o unds , ult ra vio le t s p ectra o f a roma tic a nd h et ero cyc li c
co mp oun ds. Ste ri c effect in b ip h en yls.
In fra red Sp ectro s co py
Inst ru ment at ion and s amp le ha nd lin g. C h aract er is t ic v ib ra tiona l freq uen cies o f
alka nes , al ken es, a lk ynes , aro mat ic co mp ou nds , alcoh o ls , et hers, p hen o ls a nd amin es .
Det ai le d stu d y o f v ib rat ion al freq uen cies of ca rb o nyl co mp o unds (k et on es , a ld eh yd es ,
es ters , a mi des , a cid s , anh ydrid es, lacto n es , la ct a ms a nd co n ju gat ed carb ony l
co mp oun ds) . Effect o f hyd rog en b o nding an d solven t ef fe ct o n vib rat ional
freq uen cies , o verto nes , co mb ina t ion b a nds and Fermi reson an ce. FT IR, IR o f ga seous ,
so lids an d p ol ymer ic mat er ia ls .
SE CTION - B
Nuc le a r Ma g ne tic Reso na nce Spec tro sco py
G en eral in t rodu ction and de fin it io n, ch emic al sh ift , s p in -s p in inte ra ctio n , sh i eld in g
mechan is m, mecha n is m of mea suremen t, ch emi cal sh ift valu es an d co rr elat ion fo r
p rot ons b o nded t o ca rb o n (alip hat ic, o lef in ic, a ld eh yd ic a nd aromat ic) and ot her nu c lei
(alcoh o ls , p hen o ls , eno ls , carb ox ylic acids , amin es , a mid es & mer cap t o), co mp lex
sp in -sp in in t eract ion b et ween t wo , t hre e, fo ur and fiv e nu cle i (f irst ord er s p ectra),
31
sp in s yste m-Po p le no ta tion , vi rt ua l coup lin g. St ereo chemist ry , con cep t of t op i cit y,
effect of enan t iomer ic an d d ia st ereo mer ic p rot ons , h ind ered rota tion , Karp lu s cu rv e -
va riat ion o f cou p ling cons ta nt wit h d ih ed ra l a ngl e.Fou r ier t ra nsfor m te chn iq u e,.
Res ona nce o f ot her n u clei -F, P .
Fu rt her t oo ls for s imp l if icat io n ( che mical a nd inst ru ment al ) and e l ucida te st ru ct ures
b y NMR in clu d ing a n ove rv iew of 2 D N MR T echniq ues - Deut erat ion , chan g ing
so lv ent s, t rif lu oro acet y lat ion , b as if icat ion and acid ifi cat io n , sh ift reagent s , sp in
decou p ling , CO SY, DEPT , INEP T , HET CO R, HSQ C, HMBC and NO ESY.
S ECTION - C
Ma ss S pec tro metr y
Introdu ct io n , io n p rodu ct ion - E I, C I, FD a nd FAB, factors af fect ing fragmenta tion ,

ion a nal ys is, ion a b un dan ce. Mas s sp ectral frag men ta ti on o f o rga ni c co mp oun ds,
co mmon funct iona l g rou p s, mo lecu la r ion p eak , metas ta b le p ea k, Nitrog en ru le,
mo lecu la r w eig ht det er min at ion mo l ecu la r f ormu la f ro m is ot op ic rat io da ta, iso top e
p rofile of ha lo gen co mp ound s, fa ct o rs affect ing react io n p a th wa ys , f ra gment at io n
p att ern - s imp l e c leava ge, retro -D iels A ld er, H ydro gen tran sfe r rea rrang ement l ik e
scra mb ling , o rth o eff ect , McLaffert y rea rrang emen t , fragmenta tion p a tt erns o f
hyd ro carb on s, alco ho ls, p h eno ls , et hers , al d eh ydes , k eto n es , es t ers , carb ox ylic aci ds,
amin es, n itro , a mid es , n it ri les .
Ca rbo n-13 NMR S pectro sco py
G en eral co ns id erat ions , che mical s h ift (alip h atic, o lefin i c, a lk yn e, aro mat ic,
heteroa roma t ic and carb on yl ca rb o n), coup ling cons ta nt s. nuc lear O verha user e ffect
(NO E).
Pr oblems
Prob lems p ert ain in g to se ct io ns A, B and C .
Boo ks Sug ges ted
1. Introdu ct io n t o S p ectros cop y- A G uide fo r S tu dent s of O rgan ic Che mist ry , 2 n d

Edn . By Do na ld L . P avia, G ary M. La mp man and G eo rge S. Kriz . S aun ders
G olden S unb u rs t Ser ies . Ha rco urt B race Col lege Pub lish ers , New Y ork .
2. Sp ect ro met r ic Id en t ifi cat io n o f O rga nic Comp oun ds, R. M. S ilv ers t e in , G . C.
Bas sler a nd T . C . Mo rri ll , J ohn W il ey.
3. App li cat ion of Sp ect ros co p y of O rg anic Co mp o unds , J . R. D yer, Pr en t ice Hal l.
4. Sp ect ro sco p ic Met hod s in O rg anic Chemist ry, D. H . W ill ia ms a nd I. F leming ,
T ata McG raw-H i l l.
5. Sp ect ro sco p y of O rganic Co mp o und s b y P .S. Ka ls i, W il ey Es t ern , Ne w D e lh i.
6. O rganic Sp ect g ro sco p y b y W il liam Kemp , Jo hn W i le y.
7. O rganic Ma ss S p ectro met ry b y K.G . Da s & E.P. James, O x fo rd & IB H
Pu b lish ing Co .
32
8. O rganic Sp ect ros cop y (Pr in cip les & Ap p lica tions ) b y Ja gmoha n .

Ino rga nic C he mis tr y (Spe cia l) P a per XV
Time :3 Hr s
Ma x .Ma r ks:60 +20(I A)

S ECTION – A
Rea ctio n Mec ha nis m o f Tra nsitio n Meta l C o mplexe s

Energ y p rof ile o f a react ion , r eact iv it y of metal co mp lex es , k in et ic ap p licat ion
of va len ce b o nd a nd cryst al field theo ries , kinet ics o f o ct ahe dra l sub st it ut ion , acid
hyd ro lys is , fact ors affe ct ing acid h yd ro l ys is , b a se h yd ro lys is, con jug ate b as e
mechan is m, d ir ect a nd in d irect ev id en ces in fav our of con juga te mechan is m, a nat io n
react ions , rea ct ion s wit h out met al liga nd b ond cleav age . S ub s titu tion r ea ct ion s in
sq uare p lana r co mp lex es, th e T ran s eff ect , mecha n is m o f th e s ub s titu t ion react i ons .
SE CTION - B
Electro n Tra ns fer Re a ctio ns

Red ox rea ct ion s, el ect ro n t ra nsf er react io n s, g eneral d is cuss io n an d k inet i c rat e
la ws. , mechan is m of o ne elect ro n trans fer rea ct ion s , o uter -sp h ere t yp e rea ct ion s, cros s
react ions an d Ma rcu s-Hush t heo r y, inn er sp h ere t yp e react ions , t wo electron trans fer
react ions , meta l io n cat al ys ed r eactio ns , mix ed valen ce co mp lex es and t heir el ect ro n
t ran sfer.
S ECTION - C
Rea ctio ns o f meta l co mp le xes
Rea ct io ns o f met a l co mp l ex es h aving l ig and s as nitr ile, p ho sp ha te and azide.

Rea ct iv it y o f coord inat ed h ydro carb on s: a) Nu cleop h il ic ad d it ion and su b st it ut io n b )
Rea rrang emen t r ea ct ion s, Red is tr ib ution react io ns, F lu x ion al isomeris m o f
organ omet al lics .
33
S ECTION – D
Ino rg a nic Po ly mers
Class if icat io n , t yp es of ino rga nic p oly meriz a tion, co mp a rison with or gan ic p olymers ,
b o ron -nitr og en p ol yme rs , si lico nes , co o rd in atio n p oly mers , p hosp horus -nitrog en
co mp oun ds.
No n-a queo us So lv ents
Rea ct io n in non -aq ueou s med ia wit h res p ect to H 2 SO 4 , BrF 3 , N 2 O 4 an d

p h osp horyl ch lo ride; Kin et ics a nd me cha nis m of coo rd inat ion r eact ions in non -
aq ueo us med ia.
Boo ks Sug ges ted

1 . Mechanis m of In o rg ani c R eactions ; F.Ba sol o and R.G . P earso n, Joh n W i le y a nd
So ns, N e w Yo rk.
2 . Inorgan ic Rea ct ion Mec han is m; M .L . T ob e; Nels on, Wlat on an d T hames
3 . Inorgan ic Che mist ry; K.F . Purcel l, J .C. Kot z ; Holt -San ders Int ernat io nal E d it ions;
Ph ilade lp h ia .
4 . T he Ch emist ry o f Molt en Salts ; H . Bloo m Benjamin , Ne w Y ork .
5 . Prin cip les a nd Ap p lica t ion o f O rga not ra nsi t ion M et al Chemist ry , J .P . C oll man,
L.S. Heg sdu s, J .R. Nort on an d R .G . F ink e, U niv ers it y S cien ce B ooks .
6 . T he O rg ano meta ll ic Che mis tr y of th e T rans it io n Met als; R.H. Crab t ree, Jo hn
Wil ey.
7 . O rgano met all ic C hemist ry, R.C. Meh ro tra an d A . S ing h , N ew Ag e Inte rn ation a l
8 . Coo rdina t ion Ch e mist ry; Ban erjea ; T at a McGra w H i ll.
9 . Inorgan ic Che mis tr y, A Mo d ern Int ro du ction; T . Mo el ler; J ohn W iley an d Sons .
10 . Con cep ts an d Mo dels of In o rg ani c Chemist ry; B . Dou g la s, D. H. McDan ie l and J .J .
Al ex a nder; J ohn W iley an d S ons In c.
I no rg a nic C he mistr y (Sp ecia l) Pa pe r XV I
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)
34

S ECTION – A
Al ky ls a nd Ary ls o f T ra ns it io n Meta ls
T yp es, rou tes o f s ynth es is , s ta b ilit y an d deco mp os it io n p at hways , organ oco p p er
in o rg an ic s yn thes is
Fl ux io na l Orga no meta llic co mpo unds
Flux iona lit y a nd dyn a mic eq ui lib ria in co mp o und s uch as  2 -o lefin ,  3 -a ll yl an d
dien y l co mp lex es , Carb on yl s cra mb li ng.
SE CTION - B
Co mpo unds o f Tra nsitio n Me ta l-Ca rbo n M ultiple Bo nds

Alk yl id enes , al k ylid ynes , lo w v a lent ca rb en es a nd carb yn es - s ynt h es is , nat ure
of b o nd, st ru ct u ra l c haracterist i cs , nu cleo p hi lic a nd elect ro p hi li c r eact ions on th e
l iga nds , ro le in org anic s yn th es is
Tra nsitio n Meta l Co mpo unds w ith Bo nds to Hyd roge n
S ECTION - C
Tra nsitio n Meta l  -Co mplexe s
T rans it io n metal  -co mp lex es with un sat urat ed org an ic mo le cu les , a lk en es, alk yn es ,
ally l, d ien e, d ien yl, a ren e and trien yl co mp lex es , p rep a ra tions , p ro p erties , nat ure o f
b o nding a nd s tructu ral feat ures. Imp ort ant react ions re la tin g t o n ucl eop hi lic an d
el ect rop hi l ic at t ack on l ig and s a nd t o o rga n ic s yn thes is .
S ECTION - D
Ho mog eneo us Ca ta ly sis
St oich io met ric react io ns fo r cat al ysis , h o mo g eneous ca ta lyt ic h yd roge nat io n , Zeig l er -
Nat ta p o lymeriza tion of o lefins , cat al yt ic re act ions inv ol vi ng carb on mon ox id e su ch
as hydrocarb o n ylat ion of o lefin s (ox o reacti on), ox o p alla dat io n rea ct ion s , activat io n
of C- H b ond .
Boo ks Sug ges ted

1 . Mechanis m of In o rg ani c R eactions ; F.Ba sol o and R.G . P earso n, Joh n W i le y an d
So ns, N e w Yo rk.
2 . Inorgan ic Che mist ry; K.F . Purcel l, J .C. Kot z ; Holt -San ders Int ernat io nal E d it ions;
Ph ilade lp h ia . .
35
3 . Prin cip les a nd Ap p lica t ion o f O rga not ra nsi t ion M et al Chemist ry , J .P . C oll man,
L.S. Heg sdu s, J .R. Nort on an d R .G . F ink e, U niv ers it y S cien ce B ooks .
4 . T he O rg ano meta ll ic Che mis tr y of th e T rans it io n Met als; R.H. Crab t ree, Joh n
Wil ey.
5 . O rgano met all ic C hemist ry, R.C. Meh ro tra an d A . S ing h , N ew Ag e Inte rn ation a l.
6 . Coo rdina t ion Ch e mist ry; Ban erjea ; T at a McGra w H i ll.
7 . Con cep ts an d Mo dels of In o rgani c Che mist ry; B . Dou g la s, D. H. McDan ie l and J .J .
Al ex a nder; J ohn W iley an d S ons In c.
Or
M.SC . CHEMIS TRY SE MES TER I II

PHY SICAL CHEMISTRY (SPECIAL) PAP ER XV
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)

S ECTION - A
Q ua ntum Mecha nics-I
Prob lem o f two elect ro ns , ex ch ang e int era ct io ns . Ap p rox ima te met hod s : Fi rs t
order t i me-in dep endent p ertu rb a tion t h eo ry for non -deg ene ra te s ta tes . Variat io n
t heorem and va riat io na l met ho ds . G roun d a nd ex cit ed st at e of he liu m a to m. Coup l ing
of a ngular mo ment u m for man y e lect ron s yst em, s p in -orb it co u p li ng , Mo lecu lar T erm
sy mb ols . Bo rn -O pp enheimer a p p rox imat io n, th e h ydr ogen mo lecu l e io n , th e h ydr ogen
mo lecu le , th e ir s ymmet ric a nd ant is ymmet ri c so lut ion ( wit hout a ct ua l eva luat io n o f
va rious int eg rals) .
SE CTION - B
Q ua ntum Mecha nics-II
Valen ce b on d a nd MO (LCAO ) trea tmen t of hyd ro gen mo l ecu le. Co mp a rison o f

t he MO and VB t rea tments an d t heir eq u iv alen ce l imit. Con figu rat ion In te r act ion .
Ex t en sion of MO t heo ry to ot her s ys te ms - H omon u clea r a nd het ero nu cl ear diat omi cs,
si mp le p ol yat omi c mo lecu l es .
T he p i-el ect ro n app rox imat ion , Hu cke l th eor y of co n ju gat ed s yst ems .
App li cat ions to et h yl en e, b uta dien e, c yclo b u ta diene and cyc lo p ro p en y l mo lecu l es.
Calcu la tion of p rop ert ies- D elocal iz ation en erg y, e lect ron d ens it y , b on d o rd er.
SECTI ON-C
36
Q ua ntum Mecha nics - II I
T ime-ind ep end en t p ertu rb a tion theor y f or d eg en erat e s ys te ms with ex amp les .

App li cat ions of T i me -d ep end en t p ertu rb a tion theor y. Radiat iv e t ra ns it ion s. E inst ein
co eff icient s. Q uant um mechan ica l t heo ry of a b so rp t io n of li ght b y mo le cu les .
T rans it io n mo men t int egra l. O sc il la to r st rengt h , ru l es gov ern ing th e t rans it ion
b etwe en t wo en erg y st at es . S elf -cons is t ent fi eld met hod . Ab in it io and Se mi- emp irica l
Met hod s for Clos ed She ll S yst ems .
SECTI ON-D
Mic el les
Su rfa ce a ct iv e a gen ts , clas si ficat io n of s urfac e act iv e agent s , micel l iza tion,
hyd ro p hob ic int era ct ion , crit ica l micellar co ncent ra t ion (CMC), facto rs affect ing th e
CMC of su rfact ant s, cou nte r io n b in d ing to mi cel les, t h ermod ynami cs o f
micel liza tion -p ha se sep ara tion and mass action mo d els, so lub il iz at ion , e muls io ns,
micro emu ls ion : Mech anis m of fo rmat io n an d th eir s tab il it y, re vers e m icell es.
Mic el la r cat al ysis .
Genera l Pro pertie s o f Liq uids
Liq uids as d ens e g ases, l iq uid s as d iso rdered so lids , s o me th ermo d yn amics relat ions ,
inte rn al p ress u re a nd it s s ign ifi can ce in l iq u id s , eq uat io n o f st ate, cr it ical co nst ant s,
Di ff ere nt typ es of i nt er mo lecu lar fo rc es in l iq u id s , Different p ot en tial fu n ct io ns fo r
l iq u id s , ad d it iv it y o f p air p ot ent ia l ap p rox ima tion.
Boo ks sug ges te d:
1. T heoret ica l Che mist ry , S. G las st one, A ff il ia ted E ast -Wes t Press .
2. Q ua ntu m Mechan ics , H. L. St ra uss , Prent ice Hall.
3. Q ua ntu m Ch emis t r y, B. K. S en , Ka l yan i Pub l ishe rs
4. Q ua ntu m Ch emist r y, R. Pra sad , New Ag e Int erna tiona l.
5. A tex tb ook of P h ys ica l Che mis tr y, Vol . 4 , K. L. Ka p oo r, MacMi l lan Ind ia Lt d.
6. Q ua ntu m Ch emist r y, C.R . G a tz, E .M. Co .
7. P.W. Atk ins an d R.S. Fr iedman , Mol ecu lar Q uan tum Mech ani cs , 3 rd ed it i on
(1 997 ), O x ford Un ivers it y Pr ess . O x ford.
8. H. E yring , J .Walt er and G .E. Kimb al l, Q u ant um Chemist ry , (1 9 44 ) J ohn Wil ey,
New York .
9. I.N . L ev ine, Q ua nt um Ch emist r y, 5 th ed it ion (2 00 0 ), P earson Ed u c. , In c., New
Delh i.
10 . Mic el les , T h eo ret ica l an d Ap p lied As p ects , V . Mo ro i, Plenu m.
11 . Sign ifica n ce of liq uid st ructu res , H. E yri ng
37

Phy s ic a l C he mistry (Spec ia l) Pa per XV I
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)

S ECTION – A
Sta tist ic a l Mec ha nics

Ens emb le a verag ing , p ost ulates o f ens e mb le avera gin g . Micro canon ica l,
ca non ica l and g ra nd cano n ica l ens emb les , cor res p on din g d ist rib u tion la ws (u s in g
La gra nge’s meth od of und etermind mu lt ip liers ). Max we ll - Bo lt z man n st at is ti cs,
Boltz mann d is t rib utio n, derivat io n o f t he Bo lt zman n d ist rib ut io n ex p ression ,
determinat io n o f the Bo lt zman n c ons ta nt, Ma x wel l d ist rib ut io n la w o f v e lo cit i es fro m
Boltz mann d is t rib u tio n ex p ression
S ECTION – B
Q ua ntum Sta tist ic s
T he Bos e-E ins te in sta tist ics , st at is ti cs o f a p hot on g as , t he Fermi-Di ra c

st at is ti cs , Fer mi-D irac s ys te ms , ex t re me g as deg en erat io n, sl ig ht gas degen era t ion,
el ect ron gas in met als , th er mion ic emiss io n and co mp aris on o f t wo st at ist ics , no n
degen era te a nd d eg en erat e s yst ems .
S ECTION – C
Sta tist ic a l Ther mo dy na mics

Pa rt it io n fun ct ion and t hermod y namic p r op ert ies , p artiti on fun ctio n an d
fact or iza tion o f p a rt it io n fu n ct io n, t rans la tiona l p a rt it io n fu nct io n , trans lat iona l
38
t her mod yn ami c fun ction , ato ms and mono at o mic mo lecu les , Sa cku r-T et rod e eq ua tion,
diat omi c mo le cu les , s ep arat io n of int ern al p artition fun cti on. Rota ti ona l an d
vib rat ion al en erg i es , ent ro p y du e t o int ernal d egr ees o f fr eed o m. Rot at io nal p a rt it ion
funct ion , rota t iona l p artit ion fun ct io n fo r p olyat omic mo lecu les , v ib rat io nal p a rt it io n
funct ion
SECT ION -D
Det ermin at ion an d cal cu lat io n of th er mo d yn a mic p rop ert ies i. e. int ernal en erg y,
en trop y , H e lmho lt z and G ibb s free en er g y,or th o a nd p a ra hydro gen st at es , free en erg y
funct ions .Pa rt it io n fun ct io n and eq uilib rium co nst an t, effect of nucl ea r sp in,
iso mo lecu lar react io n, isot op i c ex chan ge rea ct ion s . E in st ein t h eo ry and D eb ye th eor y
of h eat cap a cit ies of mo nat omic so l id s .
No n-eq uil ib ri um The rmo d y na mics
G en eral th eor y o f non eq ui lib ri um th ermo d yna mics, en trop y p rodu ct ion i n hea t
flo w, ma tt er f lo w an d e lect ric cur ren t , t h e O ns ager’s rec ip rocal rela t ions , t heir p ro of,
t ran sp o rt p aramet ers, t h ermo elect r ic eff ects , t her momech ani ca l p h enomena an d
t her moce lls.
Boo ks Sug ges ted

1. Introdu ct io n t o Sta tist ical T h ermo d yn a mics , H.Do l e.
2. T heoret ica l Che mist ry , S.G la sst on e, Af filiat ed Eas t -West P res s.
3. T hermo d yna mics , L e wis an d Rand all.
4. Chemical Ph ys i cs , J .C. Slat er.
5. Non -eq ui lib rium T hermod yna mics , C . Ka l ida s
Or

Orga nic C he mistry (S pecia l) Pa p er XV
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)

ca ndidat es are req ui red t o a tt emp t five q u est io ns in al l sel ect ing at least on e
S ECTION - A
Org a no me ta llic Rea g ents I
Prin cip le , p rep arat io ns, p rop ert ies and ap p li ca tions o f t he rea gen ts of t he fo llo win g
met a ls/ non -met a ls in o rga nic s ynt h es is wit h me cha nis t i c d etai ls
Li , Mg , Cd, Zn, Cu , S, S i, B and I
39
SE CTION - B
Org a no me ta llic Rea g ents II
Prin cip le , p rep arat io ns, p r op ert ies and ap p li ca tions o f t he reagents of t he fo llo wing
met a ls in organ ic s yn thes is wit h mecha n is ti c d et ai ls Pd , N i, F e, Co, Rh, C r an d T i
co mp oun ds
SECT ION -C
Oxida tio n
Introdu ct io n .D i ff er ent ox ida ti ve p rocess es .Hyd ro carb on s - a lk enes , aro mat ic r ings,
sa tu rat ed C-H g rou p s (a ct iva ted a nd una ct iv a ted) . A lcoho ls , d io ls , al deh yd es , k eton es ,
keta ls a nd carb ox yl ic ac ids .A min es , h yd razines , a nd s u lp hides .O x ida tions wit h
ruth en iu m t etraox ide , and t hal l iu m (III) n it rat e.
SECT ION – D
Red uctio n
Introdu ct io n . D if fe ren t redu ct iv e p ro ces s es . Hyd rocarb ons – a lk anes, alken es , alk ynes
an d aromat ic rin gs .Ca rb o nyl comp ound s – a ld eh yd es , k eto nes , ac id s an d th eir
derivat iv es. Ep ox ides .N it ro , nit roso , azo a nd ox ime g roup s .H ydro g en o lys is ,
Boo ks Sug ges ted

1. Modern Sy nth et ic Rea ct io ns , H.O . Hou s e, W. A. Benza min.
2. So me Mode rn Met hod o f O rg anic S ynt hes is , W. Ca rruth er , C amb ridg e Un iv .
Press .
3. Adv anced O rga nic Ch emis tr y, Rea ct io ns Mecha n is m a nd S truct ur e, J . March,
Jo hn W il ey.
4. Prin cip les o f O rganic Synt h es is , R.O .C. Norma n an d J .M. Cox o n, B la ck ie
Aca demic & P ro fes s io na l

Orga nic C he mis try (Spec ia l) Pa per XV I
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)

40
S ECTION - A
Pe ric yclic Re a ctio ns
Molecu la r orb ita l s y mmetr y, front ie r orb ita l o f et h yl ene , 1 ,3 -b ut adien e, 1 ,3 ,5 -
hex at rien e and al lyl s yst em clas s ifi cat io n of p eric ycl ic react io ns , Wood wa rd -
Hoffma nn co rrelat ion d ia gram. F MO & P MO app roach, E le ct ro c yli c rea ct ion -
co nro ta tor y a nd d isrot at ory mot ion s. 4 n, 4 n+2 , a ll yl s ys te ms , Rin g op enin g o f
cyclop rop yl hal id es a nd t osylat es , cyclo add it io ns -an tarafacia l and s up a rafacia l
ad dit io ns , 4 n a nd 4 n+ 2 s yst ems , 2 +2 add it io n o f k et enes , 1 ,3 -dip olar cyc lo addit ion s
an d chel eo trop i c R eactio n s.
SE CTION - B
Pe ric yclic Re a ctio ns
Sigmat ro p ic Rea rrang emen ts-su p ra fa cia l and ent arafa cia l shi ft s o f H, s ig ma trop ic
sh ifts inv o lv in g ca rb o n mo i et ies , r et ent io n a nd inv ers ion of con fi gurat ion , [3 ,3 ] an d
[5 ,5 ] sigmat ro p ic r earra nge ment s, d eta iled t reatment of S ommelet -Hau ser , Cla isen an d
Cop e rearra nge ment s int ro du cti on t o ene react io ns . S i mp le p rob le ms o n Pe ri cycli c
react ions , G ro up trans fers an d eli minat io ns .
S ECTION – C
Pho to c hemis try
Ex cit at io n a nd ex cite d s ta tes , Fra nck -Co nd on Princ ip le, J ab lon sk i diagra m, en erg y
t ran sfer p h ots ens it izat io n , q u ench in g , q u ant um eff ic iency a nd q ua ntu m y ield.
Ph oto che mis tr y of carb onyl co mp ou nds (No rr is h t yp e I an d t yp e II chang es ,
p h oto react io n of c ycl ic k et on es , Pa tern o -Bu ch i rea ct io n a nd Ph oto reduca t ion.
Ph oto che mis tr y o f o lefins a nd 1 ,6 -Bu ta diene (c is -t ra ns is o meris at io n , di mer is ation an d
cycloadd it io ns) . Ch emis t r y o f vis ion .
S ECTION – D
Pho to c hemis try
Di --met han e rear ra nge ment , eno n e a nd die non e rea rra nge ment s , p h oto chemis t r y o f
aromat i c comp ound s (s ub s titu tion , is o mer iz a t ion , cy cl iz ation a nd cycload d it io n
react ions ), Ph ot o -F ries rearran gement , p hot o l ys is o f n it rile este rs a nd Barton react ion ,
Hoffma n-Lo ef ller-Fr eyt ag react ion .
Applica tio n o f pho to chemis tr y - p h oto syn the sis , p hot ot herap y .
Or

Pha ra mceutica l C he mis tr y (Spe cia l) Pa per XV
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)
No te: Eight q ues tions wi ll b e s et , t wo f ro m each of th e s ect ions A , B, C & D. T h e
S ECTION – A
41
Sy ntho n a pproach-I
Def in it io n o f te rms - D is co nnect ion, s ynt h ons , fu nct iona l g rou p in t erco nve rs ion s
(FG I) , syn thet ic eq ui va len ts . G enera l p rinci p les of th e d is conn ect io n a pp roach, th e
i mp ortan ce of o rd er o f ev ent s in o rga n ic s ynt hesis , on e gro up C -X and t wo g roup C -X,
O ne group C-C disco nne ct ion s-a lcoho ls and ca rb onyl co mp ou nds , ch emo select iv it y,
rev ersa l of p o la rit y , a mi ne s yn th es is .
SE CTION - B
Sy ntho n a pproach-I I
T wo g rou p C-C d is con n ect ions -1 ,3 & 1 ,5 -difu n ct ion al iz ed co mp oun ds,
St ereo chemist ry in orga n ic s ynt h es is -s t er eo sel ect iv it y, s tereo sp ecifi cit y,
reg iose lect iv it y a nd reg io sp ecifi cit y
Synth on ap p roach in th e s ynt h es is o f t he fol lo win g drugs : Salb ut amol , Prop a nolo l,
mox nid azo le, naf imid on e, d r ildo ne, b el fos ih . O cfent an i l, afo rn in e
Prin cip le of p ro tect ion of a lcoho l ic, amino , carb on yl an d carb ox ylic group s
S ECTION – C
Syste mat ic (Hant zs ch-Wid ma n) no men clat ure fo r mo no cy lic and f used ring s ys te ms .
Met hod s of sy nt hes is and Rea ction s inclu ding mech anis m o f t he fo l lo wing five -
memb ered 1 ,2 - a nd 1 ,3 -het ero cycl es : p yr az ole, i mid azo le, ox a zole, is oox azo le,
t hia zole, iso th iaz ol e; t h eir b as ic character .
S ECTION – D
Met hod s of s ynth es is and React ions in clu ding me cha nis m o f th e fo llo wing s ix -
memb ered h etero cycl es : p ur ines a nd p yr imid ines . Ca ff eine, x a nt hin e, th eob romin e,
t heop hyl li ne
Met hod s o f s yn th esis and Rea ct ion s in c lud in g mechan is m o f -Indo les , q uino lines an d
isoq uin o lin es
Flava noids : O ccu rren ce, no men c lat ure and ge neral meth ods of s tru ct ur e det er mina tion ,
iso lat io n , i mp ortan ce an d s ynt h es is of Cya n in , Q uercetin , D iadz ein and Ch r ys in.
Boo ks Sug ges ted :
1. Des ig n in g O rga nic S ynt hes is , S .Wa rr en , Wile y.
2. So me Mod ern Met hod s o f O rg ani c S ynt h es is , W . Carrut hers, Ca mb ridg e Un iv .
Press .
3. Modern Sy nth et ic Rea ct io ns , H.O .Ho us e, W.A. Benz amin .
4. Adv anced O rga nic Che mis tr y React ions , M echa n is ms a St ru ctu res , J. March,
Wil ey.
5. Adv anced O rga nic Ch emis tr y P art B. F .A. Carey an d R.J . Su ndb erg , P lenum
Press .
42
6. O rganic Ch e mis t r y, Vo l . 2 , I.L . F inar, ELBS.

Pha ra mce utica l C he mistry (S pecia l) Pa pe r XV I
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)

S ECTION – A
Genera l mo de o f a c tio n, Medici na l Us es and Sy nthesis o f I mp o rta nt Drug s in t he

Fo llo w ing Ca te go ries .
Ant in eop las ti c Agents : M eta st as is, cla ss if ication , mod e of a ct ion o f a lk yla t ing agent s
( s ynt hes is of mep ha la n, t h io t ep a, b usu lfan, l omus t ine ) and an t imet ab olit es ( s yn th esis
of met hot rex at e, 5 -fluo rou rac il, 6 -mercap t op u rine) , hor mon e b as ed thera p ies, p lan t
p rodu ct s, radiot h erap euti c ag ent s. T ax ol rea la ted co mp ou nds .
Ant iv iral ag ent s : RN A and DN A v irus es , A n int rodu ct ion t o A IDS, h o w H IV in fe ct s
t he sys te m, mod e of action o f nu cleos id e re vers e t ra nscrip ta se inhib ito rs- AZT , d d I,
dd C, d4 T & 3 TC and H IV -p rot eas e in h ib it o rs -R it ona v ir . S ynth esis o f A ZT
An o verv i ew of H IV e ntr y inh ib ito rs , In tegrase in h ib it ors , Chemok in e re cep to r
b inders , In h ib it ors of gp 4 1 fus io n a ct iv it y
Ant ima la ria ls: Ci nch ona a lk alo id s , 4 -aminoq uino l ines , 8 -a mino q uin ol in es ,
Mef lo q uine, 9 -ami no acr id ines . S ynt hes is of Meta q uine, ch lo ro q uine, p ri maq u in e
S ECTION – B
-la ct am a nt ib iot ics

Penic il lins : D is co ver y, mo d e of a ct ion , SAR, Pen ici l lins an d semi -s ynt het i c
p enic il lins , p ro b le ms o f s en s it i vit y to acid s ,  -lact ama ses an d n arro w s p ect rum o f
activ it y; so lv ing th es e p rob lems lea d in g t o t h e d eve lo p ment o f p en ic il lin V, ox a cil lin,
clox a ci ll in , amp i cill in , amo x yc il lin, carb eni ci ll in and ca rf eci l lin; - la ct amas e
inh ib itors -Cla vu lani c acid, O livan ic acid s
43
Cep halos p orins : C lass if icat ion , SAR , s ynt hes is o f cep halos p orin -C , rece nt ad van ces o f
fourth gen erat ion cep h alo sp o ri ns
Su lfona mi des-S AR , mode o f act io n . Su lfan i la mid e a nalogs - s ynth es is of S u lfat h iazo le,
su lfad iaz ine , su lfaceta mide
T etracy clins and amino g lycos id es- St ructur e, mo d e of actio n, SAR, s t rep t omyc in ,
neomycin , genta mycin; Macrol id es- mode of act io n, erythro mycin , a zithro mycin ;
Synth es is of c hlo ra mp hen ico l
Q uinolon es , f lu o ro q uino lon es- St ru ctu re, mo de of a cti on, s ynt hes is o f n a lidix i c acid
an d cip rof lo x acin
Lin co mycins
S ECTION – C
Prost ag lan dins : G enera l Introdu ct ion , no men clat ure of p ros ta gla ndins an d eicosa noid
b ios ynt h es is
Non -St ero ida l ant i- in flammat or y agent s : Cla ssifi ca tion , mode of a ct ion , CO X -2
inh ib itors , s alo l p rin cip le
Synth es is o f c eleco x ib , valde cox ib , asp irin , p henb ut az one, mefanamic ac id ,
indo meth acin , p irox i cam, d ic lof en ac, Na p roxen
Ant ip yret i c-Ana lges i cs : o p oid ant ago nis ts a nd ago nists -cod e ine a nd hero in), s ynt hes is
of mep er id in e , met had on e, d ex trop rop ox yp h en
S ECTION – D
Ant ifert i lit y agents : O v ula tion i nhib ito rs a nd rela ted ho r mona l cont rac ep t ives -
no ret h ind rone , nor et h yn odr el, es t radio l an d mest ra nol .Re cent Adv ances
Ant ih yp ert ens iv e agent s : Cla ssi fica tio n, H yp ert en si on, R en in- Ang iot ens in s ys te m,
mod e o f a ct io n , Calciu m chan nel b lo ckers, ACE in h ib it o rs a nd -b lockers, cent ra ll y
acting adr ene rg ic d ru gs , Perip hera ll y a ct in g sy mp at hol yt ics - Synt h es is o f a tenol ol,
clo ni di ne, meth yldop a , gu anab enz , di lt ia zem, cap t op ril, enalap ri l .

1. Wilso n an d G is vo ld's T ex t b o ok o f O rganic Med icina l an d Ph arma ceu t ica l
Chemis tr y, Ed . Rob ert F . Dorg e.
2. Burger's Med icina l Ch emis t r y and Drug D is cov er y Vo l- I Ed. M .E. Wol f, Joh n
Wil ey.
3. G oo dman an d G il man's Pha rmaco log ica l Basi s of T h erap eutics , McG ra w-H i ll .
4. O rganic Ch e mis t r y Vo l. -2 I.L. Fin ar, ELBS
44
M.Sc . Che mis try (Fi na l) Se mester IV
M.Sc. Che mis tr y

I no rga nic C he mistry (S pecia l) Pa p er XV II
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)
No te: Eight q ues tio ns wi ll b e s et, t wo fr o m each of t h e se ct ion s A , B, C & D . T h e

S ECTION - A
Errors a nd Eva lua tio n
Def in it io n o f terms in mea n and median . Precis ion-st and ard dev iatio n , relat iv e
st an dard devia tio n. A ccu ra cy-ab s olute er ror, r elat iv e erro r. T yp es of error in
ex p erimenta l d at a-d et ermina te (s yst emat ic ), indet er min at e (o r rand o m) and gro ss.
So urces o f erro rs and t he eff ects up on t he an al yt ica l res u lts . Meth ods fo r rep ort ing
an alyt ica l dat a. S tat ist ica l ev a lu at ion of d at a-ind et erminat e erro rs. Sig n if icanc e of th e
F test , th e st uden t ‘t ’ t est a nd th e Chi -t est .
Nep helo metry a nd Tur bidime try
T heory - ligh t s cat t ering , cho ice and co mp aris on b et ween nep helo metr y an d
t urb idi met ry , fa cto rs a ff ect in g meas urement , in st ru ment ation , ap p licat ions
SE CTION - B
Sewa ge a nd fer ti li zer s
Sewag e trea tmen t , Bio ch emist ry o f s e wage, fert ilize rs - N it ro gen ;
ammo n if icat ion , n it r if ica t ion, d en it r if icat io n , fix at io n o f n it ro g en , b io ch e mist ry an d
eco log y o f n it rog en f ix at ion , n it ro gen and p hos p ho rus fert il iz ers in ag ri cu ltu re,
eu trop h ica tion , s urfactan ts - cat io n ic, a n io nic a nd n on ion i c, sp eci fi c p rop erties ,
degra dat ion .
45
Ana lys is o f a ir p ol lu ta nts

Bioch emical eff ect o f As and H eav y met als s uch as Cd , Pb and Hg .
Mo lecula r l uminesc enc e
Fluor imet r y a nd Phos p ho rimetr y: Introd u ct io n, p rin c ip les of f lu orescence an d
p h osp horescen c e, int erp retat ion o f f lu o rescence s p ectra, factors , fluor esc en ce
intens it y a nd co n cent rat io n , inst ru ment at io n for f lu o ri met ry , ap p lica ti ons o f
fluo ri met ry.
Ph osp h orimet ry , ins t ru men ta tion , ap p lica tio ns , co mp ariso n b etween fluo r imetr y an d
p h osp horimet ry
S ECTION - C
Chr o ma to gra phy
G en eral p rinc ip l es , t yp es o f ch ro mat ograp hy, ab sorp t ion ch ro ma tog ra p hy, p a rt it ion
ch ro ma to gra p hy, vap o ur p h ase chro mato gra p hy , p ap er an d t hin lay er ch ro ma to gra p hy,
reta rd ation fact o r, retent ion vo lu me , mech ani sm and e ff ic ien cy o f s ep a rat ions .
Io n-Ex cha nge
G en eral p rin cip les , ion ex cha ngers -na tur al and synt het ic, io n -ex chang e
ca p acit y, p urifi ca tion of wat er a nd ot h er a p p licat io ns.
So lve nt Extra c tio n
G en eral Prin cip les , ex t ract ion coeff ic ien ts , Batch, co nt inu ous , a nd cou n ter c u rren t
ex tract io ns, ap p licat io ns.
SECTI ON -D
Io n selec tiv e electrod es
Fu ndament al t yp es of elect ro d es , ga s s ens ors , ion s ens ors and enz y me
el ect rodes , p r inc ip le inv o lv ed in meas urement s wit h ion sel ect ive elect rod es wit h
sp ecial r ef er enc e t o ha lide, s u lp hid e an d o x yg en elect ro d es .
The rma l Te chniq ue s
T hermograv imet ry , d iffer ent ia l t her mal a nalys is (DT A) an d di ff erent ia l
scann in g ca lori met ry (DSC) p rin cip les and ap p lica t ions .
Boo ks Sug ges ted
1 . A T ex t b oo k of Q ua ntit ative Ino rgan ic Ana lys is , A . I. Vo g el; ELBS , Lond o n.
2 . Env iron menta l So lut io n An al ys is; S .M. Kh op ka r, W iley Ea st ern .
3 . Fu ndament als o f An al yt i ca l Chemist ry; D .A . Sko og, O .M. West an d F.J . Ho ller;
W.B. Saun ders .
4 . Inst ru ment a l met hod s o f Anal ys is ; L .L. Merits , R.H . W il lard an d J .A. D ean ; Va n
Nos trand -Re inh o ld .
5 . Ph ys ica l meth ods in Chemist ry; R.S . D ra go; Sa und ers .
46
6 . Dyn a mics of Chro ma tog rap hy Part I.; J .C. G i dd ing ; D ekk er, N ew York .
7 . Env iron menta l Che mis tr y; S. K. Ban erj i , Pren t ice - Ha ll .
M.Sc. Che mis tr y S emes ter I V

Ino rga nic C he mis try (Spec ia l) Pa per XV I II
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)

SECT ION -A
Electro a na ly tica l me tho ds o f A na ly s is
El ect ro gravi met ry: Cu rrent -v o lt ag e r elat io ns hip dur in g a n elect ro l ys is , d ec omp os it ion
p o ten tial, cons tan t cu rrent elect ro lys is , c ons ta nt cat hode p ot ent ial elect ro l ys is,
ap parat us, elect rod es , mercury cat hode , app lica t ions p h ys i ca l p ro p ert ies o f
el ect ro lyt ic p recip ita tes , ch emica l fact ors of i mp orta nce in elect rod ep o sit ion .
El ect ro lyt i cal meth ods with out cath ode p o ten tial cont ro l
Cou lo met ric ana lys is : C oulo met ric met ho d s of co nst ant electrod e p ot ent ia l a nd
co u lo met ri c t itrat ion s . Ap p arat us and ap p licat ion s .
Amp ero met r ic t it ra tions , ano di c st r ip p ing vo l ta mmet ry, a nd cy cli c vo lt ammet ry
SECTI ON -B
Ato mic Abs o rp tio n Spec tro sco py
G en eral p rin cip les , reso nan ce line , it s na tural widt h, Dop p ler effect , b ro adening
du e to p ress ur e, Ho l lo w cat hode la mp . Ap p licat ion t o a lkal i an d a lk a line eart h met a ls.
Fla me pho to metry
T heory o f fla me p hot omet r y, flame t emp erat ure, Emiss ion Fla me p ho to metr y -
intens it y of s p ect ral l ines , s e le ct ion of op ti mu m wo rk ing co n d itions , ap p licat io n o f
fla me p hot omet ry in trace met al anal ys is .
SECT ION -C
47
Spectro pho to metr y a nd Co lo rime tr y

Fu ndament al con cep ts , ins tru ment at io n for ab s orption meas ur ement s , int erf er enc es,
ap p lica tion of a b so rp t ion s p ectroscop y and Colo rimet ry to ana lys is o f in ogg an ic
su b st an ce.
Nuc le a r ma g ne tic Reso na nc e

Bas ic Pr in cip le of NMR, N u clear rela x at io n, Facto rs affect ing nu clea r relax a tion,
effect o f ch e mica l ex chan ge o n s p ectr um an d ev aluat io n o f reacti on rat e o f fas t
react ions , Doub le reso nanc e, La nth anid e s h if t reagents , an ov erv ie w of NMR o f ot h er
nu cli des wit h emp has is on 3 1 P, 1 9 F, 1 9 5 Pt and 1 1 9 Sn NMR. Ap p li cat ion in ino rg ani c
ch emistr y
SECT ION -D
Electro n Sp in Res o na nce Spe ctro sco py
Hyp erf in e cou p ling , sp in p olar iza tion for at o ms and t ra ns iti on met al i on s, sp in -
orb it cou p ling an d s ig n if icanc e of g-t enso r, ap p lica tion t o t ra ns it ion met al co mp lex es
(having on e unp a ired electron) a nd in org an ic free ra d icals su ch as PH 4 , F 2 - and [BH 3 ] - .
Dou b le res onan ce in E PR.
Circula r Dichr o is m a nd Optica l Ro ta tor y Dis pers io n
Po lariz ed l ig ht , fund ament al s y mmet r y r eq uire ment s , fo r op tica l act iv it y,
inte ra ct ion of p olariz ed light with op t ica l ly acti ve matt er, op t ica l ro tat ion , Cot to n
effect , con figurat io n o f T ris- che la ted co mp l ex es.
Boo ks Sug ges ted
1 . A T ex t b oo k of Q ua ntit a tive Ino rgan ic Ana lys is , A . I. Vo g el; ELBS, Lond o n.
2 . Fu ndament als o f An al yt i ca l Chemist ry; D .A . Sko og, O .M. West an d F.J . Ho ller;
W.B. Saun ders .
3 . Inst ru ment a l met hod s o f Anal ys is; L .L. Mer rit , R.H . W illard an d J .A . Dean; Va n
Nos trand -Re inh o ld .
4 . Ph ys ica l meth ods in Chemist ry; R.S . D ra go; Sa und ers .
5 . Dyn a mics of Chro ma tog rap hy Part I.; J .C. G i dd ing ; D ekk er, N ew York .
6 . NMR, NQ R, EP R an d MB Sp ect ros cop y in in org ani c Chemist ry, R.V . P arish , El lis
Hor wood .
7 . Modern O p t ical M et ho ds of Ana lys is; E .D . O lgen ; McG ra w H i ll .
8 . Introdu ct io n to Magn eti c Reso nan ce; McL a cha n an d Carring ton ; Ch ap ma n an d
Hal l.
48

I no rga nic C he mistry (S pecia l) Pa p er) XI X
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)

S ECTION – A
Meta l Sto ra ge Tra nspo rt a nd Bio mi ner a liza tio n

Ferr it in, trans ferrin, and s id erop hores
Ca lcium i n B io lo g y
Calcium in liv ing cells, t ran sp ort a nd regu la tion , mo le cu lar asp ect s o f
intra mo lecu lar p rocess es , ex t ra cellu lar b ind i ng p rot eins
Coenzy me v it amin B 1 2 , v ita min B 6 .
SE CTION - B
Meta llo e nzy me s
Zin c en zymes – carb ox yp ept id as e a nd ca rb o nic a nhyd ra se, a lk a l ine p hosp hat as e
an d a lco ho l d eh yd rog ena se, Co p p er enzymes – su p erox ide d is mut as e. Mo lyb denum
ox atran sfera se en z ymes – x ant hine ox ida se
S ECTION - C
Sup ra mo lec ula r Chemis try
Con cep ts a nd la ngua ge.
a) Molecu la r r ecog n itio n: Mo le cu lar recep tors for d ifferent t yp es o f mo l ecu les
inclu di ng anion ic sub st rat es , des ig n an d s ynt hes is o f co -recep t or mo lecu les an d
mu lt ip le recogn it io n .
b ) Su p ra mole cu lar rea ct iv it y a nd cat al ys is .
49
c) T ransp ort p rocesses and carr ier des ig n .

d) Su p ra mole cu lar d ev ices .
So me ex amp le of s el f-ass emb l y in s up ramo l ecula r che mis tr y
SECTI ON-D
Pr inc iples o f B io -Ino rg a nic Me dic ine
Eva lu at ion of mo d ern t h erap eut ica l, mea ns o f a dmin is t er in g ch emica ls t o
hu mans , conc ent ra t ion effects , and dos e -res p on se relat io nsh ip , fut u re dev elop ment s
an d trends in b i o-ino rga ni c t h erap y
Meta ls i n Medicine
Met al de ficienc y a nd d is ea se, t ox ic effects of metals , meta ls us ed fo r d ia gnos is an d
ch emot herap y with p art icu lar r eference t o ant icanc er d rugs
Boo ks Sug ges ted
1 . Prin cip les o f Bio ino rgan ic Chemist ry , S.J . Lip p a rd and J.M. Berg , Un iv ers it y
Scien ce Boo ks .
2 . Bio in organ ic Chemist ry , I. Bert in i , H.B . G ray, S.J. L ip p a rd and J.S. Va len t in e,
Univ ers it y S cien ce Bo oks .
3 . Su p ra mole cu lar chemist ry , J.M. L ehn , VCH.
4 . T he inorgan ic Che mist ry o f Bio log i cal Pro cess es; M.N . Huges , Jo hn Wi le y an d
So ns.

Ino rga nic C he mis tr y (Spe cia l) P a per XX
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)
S ECTION - A
Pho to c hemis try
Ab s orp tion, ex cita tion , p h oto che mica l la ws , q uan tu m yie ld , elect ron ica ll y ex cit ed
st at es - life t imes -meas urement s of t he t imes .
Ra dia tiv e a nd No n-rad ia tiv e Pro ces ses
Energ y d iss ip at ion b y rad iat iv e a nd non ra d ia tiv e p rocesses , b i mo lecu la r q uen ch in g,
ab sorp t ion s p ect ra, Fra nck co ndo n p rin cip le , p ho tochemi ca l k in et i cs , p ho tochemi cal
st ag es-p rimar y and s eco nda ry.
50
SECTI ON-B
Exc ited Sta te s o f Meta l Co mplex es
El ect ro ni cal ly ex cit ed st ates o f met al co mp lex es : c harge -t ran sfer sp ectra, ch arg e
t ran sfer t ra nsit ion , p h ot osu b st it ut io n react io ns , p ho to rea rrang emen ts ,
p h oto is omer is at ion , p hot oredo x p rocess es con dit ions o f ex c it ed st at es to b e usefu l
redox reacta nt Il lu st rat io n o f so me redu c in g a nd ox idis in g charact er o f Ru (2 + ) tris -
b ip yramidal co mp l ex . T ra nsfor mation o f chemica l ene rg y i nt o light en erg y
Meta l Co mplex Se ns i ti ze rs
Met al co mp lex sen s it izer , p hot osensit is ed react ions in meta l co mp lex es , wa ter
p h oto lys is , n it rogen fix at io n and ca rb on d io x ide redu cti on
S ECTION - C
So lid S ta te-I
Cryst a llin e and no n -c ryst all ine ma te rials , g l as s t ra nsit io n t emp erat ure T g an d
melt ing te mp erat ure T m, clas ses of comp o u nds of th e t yp e A 2 B 3 and AB 3 G la ss -
cera mics , st ru ct u res of p o lyme rs , g lass a nd cerami cs ino rgan ic chai ns an d r in gs .
Al lo ys - int erst it ia l, s ub s titu tiona l and su p er con duct ing, Meiss n er effect , Hu me -
Rot hery ru les .
S ECTION - D
So lid S ta te-II
Perf ect an d imp er fe ct cr yst als , int rins ic an d ex t rins ic def ects , p oint d ef ects ,
l ine and p lane d ef ects , va can ci es- schot t k y de fects and Franke l d efe ct s, co lou r
cent ers , no n -s t ioch io metr y and de fe ct s.
Met als, in su lat ors a nd semi con ducto rs, electron ic st ructu re o f so l id s - b an d t heo ry,
b a nd s truct ure of met a ls, in su lat ors an d semico ndu cto rs . Int rins i c a nd ex trin s i c
semicondu ct ors , dop ing s emicond u ct ors , p -n junct ions , su p ercon du ct ors , O p t ical an d
Magn et ic p rop ert ies .
Boo ks Sug ges ted
1 . Con cep ts of Ino rga n ic Pho to chemist ry , A . W. Ad a mso n an d P.D. F leis ch au er,
Wil ey.
2 . Ph oto che mis tr y o f coo rd ina tion comp ound s, K.Balza ni an d V.Carass ti,
Aca demic p ress .
3 . El emen ts of Ino rga nic P hot o ch emis tr y; G .J. F errau d i, Wi le y.
4 . An In t rodu ction t o Crys ta l Chemist ry; R.C . E van s, Ca mb rid g e Univ ers it y P res s .
5 . Introdu ct io n t o so l id s ta te Ph ysi cs ; C .Kitt el , Wil ey New Yo rk .
51
6 . So lid Sta te Ch emis t r y; N.B. Han na y; Prent ic
Or

Phy sica l C he mis tr y (Spe cia l) P a per XV I I
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)

cand ida tes are r eq u ir ed to at temp t fiv e q u est io ns in al l se le ct ing at lea st on e
q ues tion fro m each sect ion. A ll q u es tions carr y eq u al marks .
Sectio n – A
Po ly mer s
Recap it ula tio n o f b as ics o f p ol ymers a nd p o lymerizat io n. Prop erti es o f

co mmerc ia l p ol ymers : Pol yet h ylen e, p olyv in yl ch lor id e, p o lya mid es, p ol yes t ers ,
p h enol ic r es in s, ep ox y res ins an d s ili con p o lyme rs . B io deg rad ab le p olymers : T yp es o f
degra dab le p olymers , Chemical an d b iod egra dat io n . Ap p lica tio ns of d egrad ab le
p o lyme rs . Dendr imers , H yp erb ra nched – st ar p olymers a nd Plas ti cizers. Po l yme r
co mp os it es.
G lass trans it ion t emp erat ure ( T g) , fact o rs inf lu encin g t he g lass trans it ion
t emp erat ur e, i mp ortan ce o f g las s trans it io n t emp era tur e T g and mol ecu la r weig ht , T g
an d melt ing p oint . Brief d iscu ss ion on cr ys ta ll iz ation in p oly mers , a mo rp hou s
p o lyme rs .
Sectio n – B
The rmo dy na mics o f Po ly me r So lutio ns
Avera ge end-to -en d d is tan ce, a verage ra d iu s o f g yrat ion of p ol ymer chains ,
st at is ti ca l d ist rib u tion of end -t o -end d imensi ons , freel y jo int ed cha in in t h re e
di mens io ns , in f luen ce o f b o nd a ngl e r es tr ictions . Dis cus s ion a b ou t G a uss ia n chain
mod el, the wo rml ik e chain mode l.
Ent ro p y o f mix i ng and en tha lp y o f mix in g b y lat tice model , F lory Hug g in s
latt i ce th eo r y, l imitat ions o f lat t ice mod e l, e nt rop y o f mix i ng b y fr ee vo lu me t heo ry,
52
heat an d free en erg y of mix ing , p a rt ia l mo la r q ua nt it ies i. e., ch e mi ca l p ot ent ia l, h eat

of di lu t ion and p artial mo lar en trop y o f mix in g , ex c lud ed v ol ume, t h er mod yna mic
rela tions fo r d ilut e p o lymer s o lu t ions .
Sectio n – C
Pha se tr a ns it io n p heno mena in po ly me r so l ut io ns

Introdu ct ory d is cuss io n a b ou t Phas e trans it io n p hen omen a in p ol ymer s o lut ion s
(p has e sep aration , h yd rat io n, a sso ciat ion , gel at io n).
Deter mi na tio n o f Mo lecula r Ma s s o f Po ly mer s

Molecu la r mass d et ermi na tion of p oly mers . Sed iment at io n or
ultrac ent ri fu gat io n : Sed imenta t ion ve lo cit y met hod , sed ime nta tion eq uil ib ri um
met hod . L igh t scat te rin g: Sca tt er ing of l ight b y s mall mo l ecu les an d p olymer
so lu t ions , asy mmet r ic s cat tering, Deb ye met hod, Z i mm p lot met ho d, co mp ariso n o f
Zi mm an d Deb ye met hod , Smal l ang le X -ra y Sca tt er ing , d et er mina t ion of mo lecu la r
mas s b y G el P ermeat ion Ch ro ma tog ra p hy.
Sectio n – D
Adv a nced S ta tistica l Me cha nic s
Rea l ga ses , in termo l ecu la r p ot en tia l an d vir ia l co eff ic ient s .
St ru ctu re o f l iq u id s-d efin it ion o f d ist rib ut io n an d cor re lat ion fu n ct io ns,
T hermo d yna mic fun ct ions of a flu id an d rad ia l dist rib ut io n f unct ion , Pot ent ia l of mea n
forc e a nd s up erp o sition a pp rox imat io n , Kirk woo d integ ral eq u ation . S p ectros cop ic
t ech n iq ues fo r liq u id d ynami c stru ctur e st ud i es .T h eor y o f Bro wn ia n mot ion , Lang ev in
t heor y, F okk er-Planck eq ua tion and Ch and ras ekh ar eq uat ion.
Boo ks Sug ges ted

1 . Po lymer Chemist ry , P.J . F lor y.
2 . Ph ys ica l Ch emist ry o f P o ly mers, A .T ager.
3 . Ph ys ica l Ch emist ry o f Ma cro mo le cu les , C .T anford .
4 . Po lymer Chemist ry b y G o wal ika r
5 . Scali ng Co n cep ts in Po l ymer P h ys ics , Pi er re- G illes G en n es
6 . Introdu ct io n t o Pol ymers , T h ird Ed it ion, R ob ert J . Young a nd P et er A. Lo v el l
7 . Po lymer Ph ys ics (Ch emis t r y) , M . Rub ins te in, Ralp h H. Co lb y
8 . St at is tica l Mecha n ics b y Don ald A McQ ua rr ie

Phy sica l Che mis tr y (Spe cia l) Pa per XV I II
Time: 3 Hr s
53
Ma x. Ma rks : 6 0 +20(I A)

SECTI ON-A
So lid S ta te Che mis try
Free elect ro n t h eory o f met a ls, Q u ant um mecha n ical t rea t ment ex p la ining th e
orig in of b a nd gap s, dens it y o f s ta tes , Ban d t heory , B lo ch th eorem, Bri llou in zon es,
effect iv e mas s of ch arg e carri ers , Semico nd uct ors : D ir ect a nd ind i re ct b an d ga p
semicondu ct ors , h o le co ncep t, temp erat ure dep end enc e of mob i lit y, free ca rr ie r
co ncentrat io n in int ri ns ic an d ex trins i c semi con ducto rs, ma ss activ e la w, G ene rat io n
of ca rr iers and th eir r ec omb inat io n in s emico nd uct o rs. T yp es of jun ct ion s ( met al -
semicondu ct or, semicon d uctor -s emi con duct o r, ju n ct io ns in o rga ni c ma terials ), Sur face
an d int er fa ce st at es, Anal ys is o f p -n jun ct ion in clu d ing I-V charact er is t ics .
SECTI ON-B
Renewa ble ene rgy s o ur ces
Ren ewab le en erg y r es ou rces : B io mas s-Bio fue ls , H yd rog en, So lar energ y.
Relat ed en v i ron ment a l a nd eco no mi cal iss ues .
Int ro duct ion to Ph oto volta ics . Bas ic PV sys t em d es ign . Des ign and p h ysi cs o f
so la r cel ls , I- V character ist ics , ex tern a l and int ern al q u ant um eff ic ien cy.
T hermo d yna mics o f light co n vers io n . So la r radiat io n an d co nv ers ion eff ic ie ncy.
Fa cto rs in flu en cing s o lar cel l eff ic ie ncy . F utu re trend s in P V en erg y co nversi on.
Sili co n s o la r cel ls , alt erna t ives t o s il icon , III -V ma teria ls fo r so la r cel ls , t h in fi lm
so la r cells an d t hi rd gen erat ion s ola r cells . Conc ent ra to r p hot ovo lt ai cs.
T hermo d yna mic limit of l ig ht co ncentrat ors . Ph oto volta ics st o ra ge s yst em.
SECT ION – C
Adv a nced E lec tr oche mis try
Advan ced co n cep ts : O verp ot en t ial con cep t, Ex chan ge current den s it y, Bu tl er -
Vol mer eq ua tion, Po lariza b le and non-p olar iz ab le int erfaces . T afel eq uat ions.
El ect ro ch emical Proc ess es : D if fe re n ce b et ween k inet i ca ll y and ma ss t ra ns p ort
co ntro l led ele ct roc hemica l p ro ces s es. D ifference b et ween s ing le s tep a nd mult ip le s tep
el ect rode react io ns . Br ie f int ro du ct ion a nd app licat io ns o f var io us e lect roch emi ca l
met hod s : Pr in c ip le of elect ro che mica l meth ods su ch as chrono amp ero metr y, cycli c
vo lt ammet ry , chrono p ot ent io met ry, cou lomet r y, ac-i mp ed ance,
sp ect ro elect ro che mis tr y a nd h yd rod ynami c meth ods . E le ct rocat al ys is : Intr od uct io n t o
el ect roca ta lys is . Ho mog en eous a nd het erog en eou s elect ro cat alys is .
54
SECTI ON-D
Applied E le ctr ochemis tr y
Corro s ion : Fo rms of co rros ion , Corr os ion mon it orin g an d p rev ent io n meth o ds.
Bat t eries a nd Fu el cells : Int ro du ct ion . Nano structu red a nd su rface mo d if ied
el ect rodes : In t roduct ion and the ir ap p lica t ions . Env i ro n ment al ly or i ented
el ect roch emis tr y: E le ct ro chemist ry o f wa ter s p litt ing , el ect ro lys is of sea wat er,
el ect roch emica l reduct ion o f CO 2 , E le ctro ch emi cal s ewag e d is p os al, e le ct ro chemi cal
decon tamina t ion of s o il.
Io n Selectiv e Ele ctr odes
El ect ri ca l Prop ert i es o f memb rane, g lass e lec trode with s p ec ia l ref er enc e to H + ,
Na , K + ion s , op eratio n of so lid me mb ra ne el ect ro de, o p erat ion of l iq uid memb ran e
+
el ect rode , coat ed t yp e ion electrod e, Ap plica t ions of ion se lect ive elect ro d e in
determinat io n o f so me t ox i c met als and s o me anions (F - , C l - , Br - , I - a nd NO 3 - ).
Boo ks Sug ges ted
1. Prin cip les of t he Sol id St at e, H .V. Kee r, W i le y East ern.

2. So lid Sta te Ph ys i cs , C.Kit t el , J ohn W iley
3. So lid Sta te Ph ys i cs b y N e il W. As h cro ft and N. Da vid Mer min
4. T he Ph ysi cs of So lar Ce lls (Prop ert ies o f S emico nd uct o r Mat erials ) b y J enn y
Nelso n
5. Ph ys ics of So la r C ells : F rom Basi c Prin c ip les t o A dvan ced Con cep ts (Phys ics
T ex tb ook) b y Pet er Wü rfe l
6. Op t oelectron i cs of So la r C ells (SP IE Press Mono gra p h Vol. P M1 15 ) , G reg P.
Smest ad
7. El ect ro ch emical Met ho ds : Fun damen ta ls an d Ap p li ca tions , 2 n d E d ., A . J . Bard
an d L. R. Fa ulk ner J ohn W i ley & Son s : New Yor k, 2 002 .
8. Modern E lect ro che mis tr y 1 : Ion ics 2 nd Ed., Sp rin ger (1 9 98 ), J . O ’ M. Bock ris
& A. K. N. Redd y.
9. Modern E l ect ro ch e mist ry 2 B: E lectrod i cs in Ch emis tr y, E ng in eer in g , B io log y
an d E nvi ron ment al S cien ce 2 nd Ed. , Sp rin g er (2 00 1 ), J . O ’ M. Bockris & A . K.
N. Redd y.
10 . Modern E l ect ro ch emist ry 2 A: Fu nda ment als o f E lectrod i cs 2 n d Ed ., Sp ri nge r
(2 001 ), J . O ’ M . Boc kris, A. K. N . Red d y and M. E . G amb oa -Ald eco .
11 . Inst ru ment a l met ho ds o f an al ys is : W illa rd , Merr it t & D ean
12 . Adv anced Anal yt ical Ch emis tr y: Meit er and T h omas
13 . Inst ru ment a l met ho ds o f ch emi cal a nal ys is : B ra un
14 . Prin cip les of In st ru ment a l an alys is, 5 t h ed it io n, D. A. Skoo g , F. J . H ol ler, T . A.
Ni eman , Bro oks Co l e.
55

Phy s ic a l C he mistry (Spec ia l) Pa per XIX
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)

S ECTION - A
The rma l Metho d s o f A na ly s is -I
Introdu ct io n to t her mal ana lys is , T G a nd DT G , s ta tic t hermog rav imetr y an d

dyna mi c t h er mograv i met ry , Inst u men ta tion , th ermo gram, facto rs a ff ect ing
t her mogra ms, a pp licat ion o f t h er mog ravi met ry. R eact ion k in et ics– Kin et ics b y s ing le
an d mu lt ip le h eating rates . D i ff er ent ia l the rma l ana lys is , DT A t heo ries , DT A cu rv es ,
fact ors a ffe ct in g DT A curves , Ins tru ment at io n , app lica ti ons of DT A, si mu ltan eou s
determinat io n in th erma l ana lys is. Co rrela tio n of DT A an d T G A d at a wit h ex amp les .
Di ffere ntia l Sc a nning Ca lo r imetry (DSC)
Introdu ct io n , In st rumenta tion , P o wer co mp en sat ed DSC, Heat Flux DSC, DSC -
cu rv es, facto rs af fecti ng DSC cu rves , a p p lica tion s .
S ECTION – B
Ma teria l Che mis try
Def in it io n of n ano ma teria ls, v ariou s te chn iq u es fo r t he p rep ara tion o f

na nomat er ia ls ,T h er mod yn amics and Kin et i cs of Nuc leat ion , T hin Films and La ngmu ir -
Blodg ett f il ms - P rep aration techn iq ues , ev ap oration /s p ut tering , ch emica l p rocess es ,
MO CVD, so l-gel . La ng mu ir-Blo dg ett (LB) fi lm, gro wth te chn iq ues , p hot ol it ho g ra p hy,
p rop ert ies and ap p lica tions o f th in an d LB f il ms.
56
El ect ro ni c s tru ct ure an d p rop ert ies o f n anoma teria ls, op t ica l, elect rica l an d
mag net ic p rop ert ies, d if fu s io n and ch emica l b eha vio ur, ap p licat io ns o f n ano ma terials .
S ECTION – C
Pho to c hemis try
Rev is io n o f b as ic co n cep ts of p hot och emist ry, L ife t imes of ex cit ed electron i c
st at es o f ato ms and mo lecu les . Ch arg e t rans fer trans it io ns
T he F ran k-Condo n p rinc ip l e, emis s ion sp ect ra , en v iron ment effect o n

ab sorp t ion a nd emis s ion sp ect ra, W igne r’s s p in cons ervat io n r ul e.Mo des of d eca y o f
ex cited s ta tes , q u enching o f fluo res cen ce, delayed fluor es cen ce, co l lisio nal
q u enchin g , St ern– Vo lmer eq ua tion . Ex ci mer a nd ex cip l ex forma t ion an d de ca y.
T echniq u es fo r the s tu d y of tran s ient s p ec ies in p ho tochemi ca l rea ct io ns .Las ers

in p hot och emica l k in et ics .
Ex a mp les o f su p ra mo lecu lar p ho tochemist ry (V is ion , Phot os ynt h es is ) an d

p h oto chemical su p ra mol ecu lar d ev ices
S ECTION – D
Bio phy sica l Che mis tr y
Chemical b on ds in b io lo g ical s ys t ems; Pro p ert ies o f wat er; T her mod ynami c
p rin cip les in b i ol ogi cal s yst ems ; T her mod yn ami cs of B io p ol ymer So lu t ions , os mo t i c
p res sure, memb rane eq ui lib riu m, mus cu lar con tract io n an d energ y g en erat i on in
mechan och emical s yst em.
Introdu ct io n t o p ro te in fo ld ing p rob lem.
Cel l Me mb ra ne a nd T rans p ort o f Io ns : St ructu re a nd funct ions o f c ell

memb ran e. Act ive t rans p ort a cro ss cel l memb ra ne, irreversib le th ermo d yna mics
t rea tment o f memb ra ne tran sp ort .
Op t ical met hod s a nd a pp licat io ns : O p t ical techn iq ues in b io log i cal s yst ems :
Ab s orp tion sp ect ro s co p y, F lu orescence s p ect roscop y , L in ear a nd C ircu la r D ichro is m.
Boo ks Sug ges ted

1. Fu ndament als o f Pho toch emist ry, K.K. Roht a gi & Mukh erj ee , W il ey Eas tern .
2. Ph oto che mis tr y, J .G . Ca lve rt a nd J .N . P itt s, Wi le y.
3. Ph oto che mis tr y a nd Sp ect ros cop y, J .P. Simon s, W ile y Int ers ci enc e.
4. Prin cip les and Ap p li cat ions of P hot och emist r y b y B rian Ward l e
5. Inst ru ment a l met ho ds o f an al ys is : W illa rd , Merr it t & d ean
6. Adv anced Anal yt ical Ch emis tr y: Meit er and T h omas
7. Inst ru ment a l met ho ds o f ch emi cal a nal ys is : B ra un
8. Prin cip les of Bio ch emis t r y, A .L .Lehn ing er , Wo rt h Pub lis h ers .
9. Bioch emis tr y, L .St ryer, W.H .F ree man.
57
10 . Bioch emis tr y, J .Da v id Ra wn, N e il Pa tt erson .

11 . Bioch emis tr y, Vo et an d Vo et , Jo hn Wi ley.
12 . O ut lin es o f B io che mis tr y, E.E .Conn an d P.K. St ump f, Jo hn Wi l ey.
13 . Bioorgan ic Che mis tr y: A Chemica l Ap p roach to Enz yme A ct io n, H .Duga s
an d C. Pen n y, S p ring er- Ver lag .
14 . Macromo lecu l es : S tru ct ur e and Fu nct io n , F. Wold , Prent ice Hall .
15 . Biop hys ica l Ch emist ry, Vo l. 1 -3 , C. R . Ca nt o r & S ch immel
16 . Ph ys ica l B ioch emist ry : Ap p licat ion s to Bi och emis t r y and Mo lecu la r B io log y b y
D. M. Frei fe ld er
17 . Biop hys ica l Ch emist ry: Pr in cip les and T ech niq ues b y A . Up adh ya y, H ima la ya
Pu b lish ing Ho use

Phy sica l C he mistry (Sp ecia l) Pa pe r XX
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)

SECTI ON-A
Adv a nced C he mic a l Ki net ic s
Lon don -E yr ing-Po lany i met hod o f cal cu lat ion of en erg y of a ct iv ati on .
App li cat ion of act ivat ed co mp lex t heory of r eaction ra tes .T emp era tur e d ep enden ce o f
p re-ex p onen tial fa cto r. T hermod yna mi c a sp ect s of react io n rat es . Kas sel’s th eor y
(RRK), Ri ce-Rams p erger-Ka ss el-Marcus (R RKM) t heo ry , uni mo lecu lar react ions an d
its va lid it y.
SECTI ON-B
Rea ctio n Dy na mic s
Molecu la r b eams , p r inc ip le of cros s ed -mo l ecula r b ea ms . Mo lecu la r en co unt ers
an d p rin cip al p a rameters , e .g . Imp act p aramet er , Coll is ion c ros s-s ect ion , React io n
cros s-s ect ion a nd relat io n b etween react io n cros s-s ect ion and react io n rat e (s ing l e
veloc it y) . Dep end ence o f co l lis iona l cross -s ect ion on trans la tiona l en erg y.
Prob ing the trans it ion s tat e, D yn amics o f b a rrie rless ch emical k inet ics in
so lu t ion , d yna mics o f un i mo lecu lar rea ct ion s .
So lut io n K inet ic s
Ion- ion react ion, ion -d ip ole r eact ion and enz yme k in et ics (effect of p H an d
t emp erat ur e). L in eweane r-Burk p lot fo r t he ana lys is of enz ymo l ys is. R ea ct ion s
b etwe en p o lar mo lecu les , k in et ic sa lt , sa lt eff ect .
58
SECTI ON-C
Kinet ics o f Fa s t Rea c tio ns
G en eral t reat ment of cha in rea ct ion , a ppa ren t a ct iva tio n energ y o f chain
react ions , cha in lengt hs , th eor ies o f b ranchin g chain and ex p losion (h yd rogen -o x yg en
react ion) . Mo d ern t ech n iq ues i n g as p has e a nd in so lut io n, flash p h oto lys is , flo w
met hod s , re la x at io n t ech niq ues (t emp eratu re ju mp , p ress ure ju mp ) and sho ck tub e
t ech n iq ue.
SECTI ON-D
Liquid Cr y sta ls
Mes mo rp hic b ehaviou r, th ermo trop i c l iq uid cr yst a ls, p o sit iona l o rde r, b on d
orient ation a l ord er , ne mati c and s mect ic mes op has es; s mect ic – n emat ic t ra nsit ion an d
cl ea ring te mp eratu re – homeot rop ic, p lan ar an d s chl ie ren t ex tures , t wist ed n ema t ics ,
ch irals n emat ics , mo lecu la r arran gement in sme ct ic A a nd s mect ic C p h ases, op tica l
p rop ert ies of liq uid cr ys ta ls . Di ele ct ri c su scep t ib i l it y an d dielect ri c co nst an ts.
Lyo t rop ic p ha ses a nd t hei r d es cr ip t ion o f ord er in g in l iq u id cr ys tals .
Boo ks Sug ges ted
1. T heoret ica l Che mist ry , S. G las st one, A ff il ia ted E ast -Wes t Press .
2. Mic el les , T h eo ret ica l an d Ap p lied As p ects , V . Mo ro i, Plenu m.
3. Mat eria l Sci enc e Eng ineering , W.D. Cal l is ler , J r.
4. Chemical Kinet ics, K.J. L a id ler, McG ra w H il l
5. T heories o f Ch emi ca l Rea ct ion Ra tes , K.J. L a id ler , McG raw H il l.
6. T heory o f Ra te Process es, S . G las st one , K.J . Laid ler and H. Eyrin g, McG ra w
Hi ll .
7. Rea ct io n Kin eti cs O x ford P res s (1 997 ), M . J . Pil ling a nd P. W . S eakins .
8. T hermo trop i c L iq uid C r yst als , G .W . G ra y, J o hn W il ey.
9. Han db oo k of L iq uid Crys ta ls , Kelkar and Hat z, Ch emie V erlag .
10 . Sign ifica n ce of liq uid st ructu res , H. E yri ng
Or

Orga nic C he mis tr y (Spe cia l) Pa per XV I I
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)
can did at es ar e r eq u ir ed to at t emp t five q ues tions in a ll, \ s elect ing atl ea st on e
q ues tion fro m ea ch se ct ion . A ll q ues tions car ry eq u al ma rks .
S ECTION - A
59
Disco nnec tio n Appr oach -I

An int ro du ct ion o f s ynt hon s a nd s ynt het ic eq uiv alent s , general p rin c ip les of th e
disc onne ct io n a p p roach, fun ct iona l g ro up int erco nvers ions , th e imp o rt ance of ord er o f
ev ent s in organ ic s ynth es is, o n e gro up C -X and two group C -X dis conne ct io ns , on e
group C-C disconn ect io n , ch emos elect iv it y, reg ios e le ct iv it y, reg iosp ecifi cit y,
st ereos elect iv it y and s t ereo sp ecifi cit y.
SE CTION - B
Disco nnec tio n Appr oach -I I

Rev ersa l o f p olarit y, a mine s yn th es is ,Syn th e sis o f alk en es -us e o f w it tig r ea gent s,us e
of acet yl ene an d a l ip hat ic n it ro co mp ound s in o rg ani c s yn th es is, s ynt hes is o f t hree
memb ered r ing s, p ho to che mist r y in organ ic syn th es is -s yn th es is o f four memb ered
ring s , us es of keto n es in o rg ani c s ynth es is, s ynt h es is o f five a nd s ix me mb ered rin g s
S ECTION - C
Disco nnec tio n Appr oach -I II
Prin cip le of p rote ct io n o f a lco h ol ic, a min o , carb on yl and ca rb o x yl ic gr oup s , T wo

group C-C dis conn ect io n- D ie ls A lder react i ons , 1 ,3 -difunct iona lized comp ou nds a nd
, uns at ura ted ca rb o nyl co mp o und s, co nt ro l in carb on yl cond ens at ion s, 1 ,5 -
difu nct io nal iz ed co mp o und s- Mich ael a dditio n, a nd Ro b in son Ann ela tion .
disc onne ct io n a pp roach to ward s the s ynt h es is of J uva b ione and t heir re la tiv e mer it s
an d demer it s.
S ECTION - D
Pr inc iple o f Gr een che mis tr y a nd its a pplica tio ns
Bas ic Prin cip le an d ne ed of g reen ch e mis tr y, D if fe rent to o ls fo r green s yn th es is (

El emen ta ry id ea of gr een reag ent , green s o lv ent , gr een ca ta lys t, s o l id p h ase, mw an d
ultras oun d as sist ed) a tom eco no my, Ro le o f b ioca ta lyst s in g re en s ynt hes is - enz yme
ca ta lyz ed ox idat io n , redu cti on a nd h ydro l ytic rea ct ion s , s ynth es is inv o lv in g b a sic
p rin cip le o f g re en ch emis tr y-s yn th es is o f ad ip ic ac id an d BHC s ynt hes is o f Ib u p rofen.
Sup ra mo lec ula r che mistry
An id ea of su p ra molecular chemist ry, Phas e T ran sfer Cat alys is, C ro wn et h ers ,
cr yp t at es , cyc lo d ex t rins , cal ix arenes , an d mi ce lles
Boo k S ug ge te d
1 . Des ig n in g O rga nic S ynt hes is , S .Wa rr en , Wile y.

2 . So me Mod ern Met hod s o f O rg ani c S ynt h es is , W . Carrut hers, Ca mb ridg e Un iv .
Press .
3 . Han db oo k o f G reen Ch emis t r y- G re en Cat al ys is- Pa ul T . Ana sta s, Ro b ert H .
Crab t ree, W iley -VCH
60
4 . Met hod s a nd Reagents for green s ynt hes is : An int rod uct io n , Piet ro T u ndo,
Alv is e Peros a, F. Z ecch in , W iley

Org a nic C he mistry (Sp ecia l) Pa pe r XV II I
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)
can did at es are r eq u ir ed to at te mp t fiv e q ue st io ns in a l l sel ect ing at lea st on e
S ECTION - A
Rea ctio ns
A det ai led s tu d y in clud ing mech an is m or Arn dt -Eist ert s yn th es is Beck mann , Hof mann,
Curtius , Lo ss en , Sch midt , Favo rs k ii , Neb er, Frits ch -But en b erg-Wi ech ell, Baey er-
Vi ll ig er, Benz ilb en zil lic ac id rear ra nge ment s .
SE CTION - B
Rea ctio ns
A d et ailed st ud y in clud ing mechan is m Darzen s s ynt hes is , st ro ke enamin e synth es is,
Sh ap iro react ion; Sh arp lcss as ymmet ri c ep ox ida tion,Pr evo st an d Woo d ward
hyd ro x ylat ion
Fla vo no ids
O ccurren ce, n o men c la tu re, g enera l (ch emi cal a nd sp ect ros cop ic) meth ods of s tru ct ure
determinat io n of f la von o id s , Iso lat ion an d s ynt h es is o f Cyan in , Q uercet in , D iad zein
an d C hrys in . B ios ynth es is o f F lav ono ids : Acetat e p a thwa y and Sh ik i mic a cid p at hwa y,
b ios ynt h es is o f cat ech in .
S ECTION - C
61
Hetero cy c lic co mpo unds

Syste mat ic (Ha nt zsch-W id man ) n o men cla tu re fo r mo no c ylic and fu sed r ing s yst ems .
Met hod s of s ynt h es is an d Rea ct io ns inc lud in g mechan is m o f th e fo llo wing . Fiv e -
memb ered h et ero cyc les : p y raz ole, imid a zole, ox azo le, is oox a zole, t h iazo le,
isot h iazo le; the ir b asic ch ara ct er
S ECTION – D
Hetero cy c lic co mpo unds
Met hod s o f s ynt h es is o f t he fo ll o wing s ix -memb ered h et ero cyc les : p yr imid in es a nd
p u rines .
Aro ma ticity , Meta l lo c ene s a nd No nb enzeno id Aro ma tics Co mpo unds
Aro mat ic it y (aro mat ic , non -aro ma ti c, an d a nt ia ro ma tic), aro mat icit y i n cha rge d r ings,
ho moaro mat ic it y, p s ued o -a ro ma t icit y , HMO an d PMO fo r d et ermin ing aro mat ic, non -
aromat i c a nd ant i-aromat ic charact er o f annu le nes ha v ing var io us -e le ct ron s yst ems,
ap p lica tion o f 1 H -NMR in det ermin ing aro ma t ic ch aract er of annu len es .
G en eral co ns id erat io ns, s yn th es is and react io ns o f rep resen ta t ive co mp ound s
Ferro cen e, Az u len e, T ro p ones and T rop o lo n es .
Boo k S ug ge te d
1 . Des ig n in g O rga nic S ynt hes is , S .Wa rr en , Wile y.

2 . So me Mod ern Met hod s o f O rga ni c S ynt h es is , W . Carrut hers, Ca mb ridg e Un iv .
Press .
3 . Modern Sy nth et ic Rea ct io ns , H.O .Ho us e, W.A. Benz amin .
4 . Adv anced O rga nic Che mis tr y React ions , M echa n is ms a St ru ctu res , J. March,
Wil ey.
5 . Adv anced O rga nic Ch emis tr y P art B. F .A. Carey an d R.J . Su ndb erg , P lenum
Press .
6 . O rganic Ch e mis t r y, Vo l . 2 , I.L . F inar, ELBS.
7 . Het erocy li c Ch emist ry, T .L. G il ch rist , Lon g man Sci en ti fic T ech n i cal .
8 . Comp reh ens iv e Het ero c ycl ic Chemis t r y, A .R. Ka tr it zk y an d C.W. Rees , eds .
Perga man Pr ess .
9 . Po lyc ycl ic Aro mat ic H yd ro carb on s, E. C la r, Acade mic Press .
M.S c. Che mis try (Fina l) S emes ter I V

Orga nic C he mistry (Spec ia l) Pa per XI X
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)
62

ca ndidat es are req ui red t o a tt emp t five q u e st ions in al l se lect ing at least on e
S ECTION - A
Enzy mes
Introdu ct io n an d his to ri cal p ersp ect iv e, che mica l an d b iolog i ca l cat al ys is , rema rk ab le
p rop ert ies o f enz ymes l ike cata lyt ic p ower, sp ecifi cit y an d r egu la tion . No men clat ur e
an d cla ssi fica ti on, ex t raction an d p urifi ca tio n. F is cher's loc k a nd key a nd Kos h lan d 's
indu ced f it h yp ot hes is , con cep t an d ident ifi cat io n of act iv e s it e b y th e us e o f
inh ib itors , a ff in it y lab eling . Enz yme k in et ics , Michae lis-M ent en an d L ine weav er-Burk
p lot s, rev ers ib l e an d i rr ev ers ib le inh ib iti on.
Mecha nis m o f Enzy me Actio n
T rans it io n-s ta te th eo r y, or ien ta tion and st eri c effect, ac id -b as e cat al ys is , co val en t

ca ta lys is , st ra in or d is to rt ion
SE CTION - B
Mechanis m of a ct ion of ch ymo t r yp s in, carb ox yp ep tida se A and p ap ain.
Co -Enzy me C he mistr y
Cofactors a s deriv ed fro m v ita min s, co en zymes , p rost het i c gr oup s, ap oenzymes .
St ru ctu re an d b io lo g ical fu nct io ns of co enz yme A , th ia mine p yro p hos p ha te, p yr id ox al
p h osp hat e, NAD + , NADP + , FMN , FAD , Me cha nis ms o f rea ct io ns cat al yzed b y th e
ab ove co fa ct ors
Pr o stag la ndins : G ene ra l In t rodu ction , n omen clat ure a nd b io log ica l ro les o f
p rost ag la ndins. S ynt hes is o f PG E 2 a nd PG F 2 α .
S ECTION - C
Terpeno id s
G en eral as p ect s of st ru ct u re d ete rminat io n of t erp en o id s, st ru ct u re an d s ynt h es is o f
G eranio l, -t erp in eo l, -p in en e, ca mp hor a n d sq u alene . B iog enet ic is op rene ru le a nd
b iogenes is o f te rp enoids .
S ECTION – D
Stero ids
Is olat ion and n o menc la ture of st ero id s , s truct u re, s ynt h es is (Wood ward ) an d
st ereo ch emist ry o f cho les t ero l , met ho ds fo r t he fo l lo wing conv ers ion s .
i) Cho lest ero l  T est ost eron e
i i) Cho lest ero l  Progest ero n e
i ii) Cho lest ero l  5 - and 5 - cho lan ic ac id s.
iv) Jo hns on's h yd ro chr ys ene ap p roa ch t owards t h e s yn th es is o f, And ros terone .
63
Boo ks Sug ges ted

1 . O rganic Ch e mis t r y, Vo l 2 , I. L . F inar, ELBS.
2 . Nat ural Produ ct s : Che mis tr y a nd Bio lo g y Sig nifi can ce, J .Man n, R.S. Dav id s on,
J.B. Ho b b s, D.V . B ant hro p e an d J .B . Harb orne, L ong ma n, Es sex .
3 . Bioch emis tr y, A .L . Lehn ing er.
4 . O ut lin es o f B io che mis tr y, Co hn & St ump f.

Orga nic C he mistry (S pecia l) Pa pe r XX
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)
No te: Eight q ues tio ns wi ll b e s et, t wo fro m each of t h e se ct i on s A , B, C & D . T h e
can did at es are r eq u ir ed to at te mp t fiv e q ue st io ns in a l l sel ect ing at lea st on e
SECTI ON A
Drug De sig n
Class if icat io n and dis cov er y of n ew dru gs , h is to r y a n d develop me nt o f

ch emot herap eut ic a gent s , th era p eut i c ind ex , L D5 0 and ED5 0 , na ming o f (n e w) drugs .
El emen ta ry id ea ab o ut drug action : t h e recep to r ro le, n eurot ran s mitt ers and re cep to rs,
ion chan nels a nd t hei r con tro l, memb ran e b o und enz ymes -act iva tio n/ dea ct iva tion ,
ch emica l b a sis of mes sen ge r in du ced cha n ge of sh ap e b y the recep to r, des ign o f
ag onist s, a nta gon is ts a nd p artial a gon is ts
Drug d ev elo p men t : s cre en ing of n atu ra l p ro d uct s, is o la t ion and p urifi ca tion , s tru ct ur e
determinat io n, st ru ctu re-act iv it y relat io nsh ip s (SAR), s ynt h eti c a nalog u es , iso ste res
an d b io is ost er es, co nc ep t of lead co mp oun ds.
Brief o verv iew o f p ha rmacok inet ics and p h arma cod yna mics , con cep t of p rod rugs an d
syn erg is m.
SECTI ON B
64
Sy nthe sis, Ge nera l Mo de o f Actio n a nd Medicina l Use s o f I mp o rta nt Drug s in the

Fo llo w ing Ca te go ries .
Ant in eop las ti c Ag ent s : Mech lo ret hamin e, Ch lora mb ucil , c yclop h osp hamid e,
ca rmus t in e, aminop ter in , 6 -mercap top urin e, p aclita x el (s ynt hes is o f p a clit ax el
ex clud ed )
Ant ima la ria ls: Ch loroq u ine , p r ima q uin e, ch lo ro gua nid e, p y ri met hamin e’
Ana lg es i cs , Ant ip y rics an d Anti in flammat or y a gen ts : Morp hine and related comp ound s
(cod ein e a nd hero in), mep er id ine , met had on e, a sp irin , a cet aminop hen , i nd o met hac in ,
p h enylb u taz one, mef ena mic ac id , ib up rofen, diclo fena c, na p rox en , ce lecox ib .
Ant ifert i lit y agent s : O vulat ion in h ib it ors and rela ted h or mona l cont rac ep t ives -
no ret h ind rone , n o reth ynod rel , est ra dio l, mest ranol , n on h o rmon al con tracep tive -
cent chro man (s yn thes is of al l t he dru gs ex clu ded).
Cardiova scu la r Drug s : Ca lc iu m cha nne l b lock ers a nd -b lo ckers : sorb itrat e, d ilt iaze m,
at en olo l and v era p ami l.
A IDS an d d rug s a gains t H IV : Ho w H IV in fect s the s yst em, st ru ctu re an d mod e o f

action of i mp ortan t dru gs aga in st H IV (n u cl eo sid e rev ers e t rans cr ip t as e inh ib it ors ) -
AZT , dd I, ddC, d4 T and 3 T C (synth es is on l y of A ZT ).
SECT ION -C
Ant ib io tic s
Cel l wa ll b io sys nt hes is and p ro tein s ynt hesis inh ib it ors : Pen ici l lins a nd s emi -
synt h et ic p en icil l ins , s ynth es is , s tru ctur e elu cidat ion and med i cina l us es of p en ic il lin
G , p rob lems of se nsit iv it y t o acid s , -la cta mas es and narro w sp ect ru m of act iv it y,
so lv ing th ese p ro b le ms lead ing to th e d ev elop men t of p en ic il lin V , ox a ci ll in ,
clox a ci ll in , a mp ici ll in , a mox yci ll in , ca rb eni ci ll in an d carfecil l in .
Cep halos p orins - D is cove ry , st ructu re elu c id a tion an d s ynt hes is of cep halos p orin -C .
SECT ION -D
Al ka lo id s
Def in it io n , no men clatu re and p hys io lo g ical act ion , occurren ce, iso lat io n , g en era l
met hod s of st ru ctu re elu cidat io n , d egrad a tion, clas sifi cat io n b as ed o n n itrog en
hetero c ycl ic r in g , ro le o f alka lo ids in p lan ts .
St ru ctu re , st ereoch emis tr y, s ynt h es is an d b ios ynt h es is o f t he fo llo wing : Ep hedrin e,

(+)-Con i in e, N icot in e, Q u in in e an d Res erp in e.
Boo ks Sug ges ted
1. Peri cycli c R eact ions , S.M . Muk herj i Macmila n Ind ia .

65
2. Wilso n an d G is vo ld's T ex t b o ok o f O rganic Med icina l an d Ph arma ceu t ica l

Chemis tr y, Ed . Rob ert F . Dorg e.
3. Burger's Med icina l Ch emis t r y and Drug D is cov er y Vo l- I Ed. M .E. Wol f, Jo hn
Wil ey.
4. G oo dman an d G il man's Pha rmaco log ica l Basi s of T h erap eu tics , McG raw-
Hi ll .
5. O rganic Ch e mis t r y Vo l. -2 I.L. Fin ar, ELBS.
6. O rganic Pho to chemist ry , J Cox a n & B. Ha lt o n, Camb r id ge Un iv ers it y Pres s .
7. Introdu ct ory Ph oto ch emis t r y, .A . Co x and T . Ca mp McG raw Hi ll .
8. T he Con serva tio n o f O rb ita l S ymmet ry, R. B. Wo od wa rd and R . Ho ff mann "
Ver la g Ch emi e Acad emi c Press.
9. Prob lem So lv ing ap p roa ch to O rb ita l Symmet ry, R.E . Leh r and A.P . M er cha nd
10 . O rganic R ea ct ion s and O rb it al Sy mmetr y, T .L. G il ch rist a nd R.C. S tor r,
Camb ridge Un iv ers it y P ress , Camb r idg e, 2 n d Ed n. 1 9 79 .
Or

Pha rma c eutic a l C he mistry (Spec ia l) Pa per XV II
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)
ca ndidat es a re req uired t o a t temp t five q uest io ns in all s elect ing at l eas t one q u est io n
SECTI ON-A
Mecha nist ic a nd b io s y nthetic a ppro ach to p la nt sec o nda ry meta bo lites :
Aceta te -ma lona te p at hway : Bios ynt h es is o f p lan t fatt y acid s, b io s yn th es is a nd

ox ida tion of ricino l ei c a cid ). Po lyk et id es : Bios ynth es is of 6 -meth yls al ic ycl ic ac id ,
p enci ll ic a cid , g r is eo fu lvi n
Aceta te - mevalon ate p a th wa y: B ios ynt h es is of p soralen , g ib b erel lic a cid , ch o lest ero l,
co nes s in e
Sh ik imic-a cid p at hwa y: B ios ynt h es is o f chlor ogen ic ac id a nd c ichor iin , C yan in ,
Q uercet in ,
Bios ynth es is of P orp hyr in s
SECTI ON-B
Alka lo ids : D efin it ion , no me nclat ure a nd p hys io lo g ical act ion , o ccu rrence, is o la tion ,
general metho ds of s truct u re e lu cidat io n , deg ra dat io n, clas si ficat ion b as ed on nitrogen
hetero c ycl ic r in g , ro le o f alka lo ids in p lan ts .
St ru ctu re , s ynt h es is , b ios ynt h es is an d bio log ica l imp ort an ce o f t he fo llo wing :
Ep h edrin e, (+ )-Con i in e, N i co tin e, Q u in ine a nd Res erp in e.
66
Carot eno id s; St ru ctu re , s yn th es is and b iog en esis o f -carot ene a nd Vit a min-A
S ECTION – C
Carb oh ydrat es: Int ro du ct ion, s t er eo iso meris m, mu ta rot at io n o f mo nos acchar id es , r ing
st ru ct ure o f g lu cos e, s tr uct ur e elu cidat io n , o f d is acchar id es , s u cros e, malto s e, la cto se,
p o lys ac char ides , st ar ch, g lycos ides , g en eral s tructur e elucidat ion
T erp enes
G en eral in trodu ct ion , iso p ren e ru le , is o la tio n of terp enes , G en era l met h ods o f
st ru ct ure d et ermin at ion o f terp enes , s tru ct ure eluc ida t ion o f c it ra l, ment ho l an d
ca mp hor
S ECTION – D
St eroid s: Is o lati on , n omen cla tu re, s tru ct ura l elu cidat io n with sp ecia l ref er enc e t o
Cho lest ero l, ergo st ero l an d card ia c g l ycos id es
Met hod s for t he fo llo win g co nve rs ion s :
v) Cho lest ero l  T est ost eron e
vi) Cho lest ero l  Progest ero n e
Po rp h yrins
St ru ctu res e lu cidat io n o f ch lorop hy ll , G ene ra l st ru ctu ral fea tures o f haemo g lob in (not
st ru ct ure e lu cid at ion ).

1. O rganic Ch e mis t r y, Vo l 2 , I. L . F inar, ELBS.
2. Nat ural Produ ct s : Che mis tr y a nd Bio lo g y Sig nifi can ce, J .Man n, R.S. Dav id s on,
J.B. Ho b b s, D.V . B ant hro p e an d J .B. Harb orne, Lo ng ma n, Es sex .

P ha ra mceutica l C he mis tr y (Spe cia l) P a per XV I II
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)
S ECTION – A
Drug De sig n
Introdu ct io n , P ro cedu re fo l lo wed in d ru g desi gn -Screen in g of na tu ral co mp oun ds,
iso lat io n , p u ri ficat io n, s t ruct u re d et ermina t io n, S earch fo r lead Comp o unds , Mo lecu la r
Modifi ca tion of L ea d Co mp oun d, p rodrugs - u tilit y , dru g lat ent iation , carri er linke d
an d b iop recurso r p rodrugs , P ro dru gs of co mp ound s cont a in ing a lcoho ls , carb ox yl ic
acid s , amin es a nd carb onyl gro up s , dru g s ynerg is m, h ard an d s oft d rug s. St ru ctu re -
Act iv it y Relation sh ip (SAR) , is os teris m, B io is os ter is m, Facto rs af fe ct ing B ioacti vit y,
T heories o f Dru g A cti vit y; O ccu p an cy th eor y, Ra te t heo ry, Indu ced F it t h eo ry
67
S ECTION – B
Q ua ntit ative s truct u re -act iv it y relat io nsh ip s (QSAR) - Dev elo p men t of Q SAR,
Ph ys ico chemi ca l p arameters - L ip op hilicit y p aramet er , Po lariz ab ilit y, E lectron i c
p a rameter, Ion iz ation C ons tan ts , s t er ic Paramet ers - T aft’s st eric facto r, mo la r
refract iv it y, Verlo o p s teric p a ramete r, chelat io n p aramet ers , S urface act iv it y
p a rameter, r edo x p otent ia l, ha nsc h ana lys is , Cra ig p lot , T op liss Sch eme, F ree -W ilso n
App roa ch
Co-Enz yme Chemist ry
Cofactors a s deriv ed fro m v ita min s, co en zymes , p rost het i c gr oup s, ap oenzymes .
St ru ctu re an d b io lo g ical fu nct io ns of co enz yme A , th ia mine p yro p hos p ha te, p yr id ox al
p h osp hat e, NAD + , NADP + , FMN , FAD , Me cha nis ms o f rea ct io ns cat al yzed b y th e
ab ove co fa ct ors
S ECTION – C
Co mbi na to r ia l Che mis tr y
Introdu ct io n to Comb inat or ial ch emist r y, Comb ina toria l a p p roaches , s ol id p has e
t ech n iq ues , liq u id p has e s ynt hes is , Ch emica l Pep tid e and s ma ll mo lecu la r l ib ra ri es,
sp lit s yn th esis and p a ral lel s yn th es is- a p p lica tion s a nd meth odo log y, d econ v ol utio n,
Comb ina to ria l O rg ani c S ynt h es is , High t hro ught p ut s creen ing (HT S), Plann in g an d
desi gn ing a co mb in at orial s yn thes is -sca ffold s , X-ra y cr yst a l lo gra p hy, doc ki ng
p rocedur es .
S ECTION – D
Enzy mes
Introdu ct io n an d his to ri cal p ersp ect iv e, che mica l an d b iolog i ca l cat al ys is , rema rk ab le
p rop ert ies o f enz ymes l ike cata lyt ic p ower, sp ecifi cit y an d r egu la tion . No men clat ur e
an d cla ssi fica ti on, ex t raction an d p urifi ca tio n. F is cher's loc k a nd key a nd Kos h lan d 's
indu ced f it h yp ot hes is , con cep t an d ident ifi cat io n of act iv e s it e b y th e us e o f
inh ib itors , a ff in it y lab eling . Enz yme k in et ics , Michae lis -M ent en an d L ine weav er-Burk
p lot s. En z yme inh ib ito rs - rev ers ib le, ir rev ers ib le , su ic id e s ub s trat es.
Mechanis m of En z yme A ctio n
T rans it io n-s ta te th eo r y, or ien ta tion and st eri c effect, ac id -b as e cat al ys is , co val en t
ca ta lys is , st ra in or d is to rt ion

Pha rma ce utica l C he mistry (S pecia l) Pa pe r XIX
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)
68

SECTI ON-A
Pa tents
Brief int ro duct ion to IPR, Def in it io n , n eed fo r p at ent in g, T yp es of P at ent s, c ond it io n s
t o b e sat is fi ed b y a n inv ent io n t o b e p a tentable, f eat ures
Introdu ct io n t o “ T he Pat ent s Act 1 9 70” an d “ T he Pat ent Ru les 2 0 03 ” , “ T he Pat ent
Rules 2 0 05 ”wit h s p ec ia l e mp ha sis o n t he fo rms to b e su b mit t ed alo ng w it h a pat en t
ap p lica tion .
Drug & Co s met ic A ct wit h sp ecial r eference t o sch edu le Y and M .
G ATT , WT O
SECTI ON-B
St ab il it y t est i ng o f n ew d rug sub st ances and p roducts : D rug su b st ance – cr it er ia,

st orage con d it ions , lo ng term t es t ing , accel erat ed t es tin g, freq u en c y, eva lua t ion,
lab ell ing ; Drug p rodu ct – S elect io n o f b at ches crite ria, sp eci fica tio n, cond it ion s o f
st orage a nd t est ing , Cal cu lat ion of sh el f li fe an d ex p iry d at e of p roducts
Q ua lit y cont rol and Q ua lity As suranc e: Req uirement s o f G MP, cG MP, G LP, ISO -9 000 ,
regu lat or y req uirement s o f drugs and p ha rmaceut ical (USF D -NDA/ A NDA ), to tal
q u alit y ma nag emen t (T Q M) Co ncep t.
SECTI ON-C
Imp urit y an d St ab ilit y: N ew d ru g p rodu ct s – Dis solut io n , d is in tegra t ion , h ard nes s
friab ilit y , un ifo rmit y o f do sag e units , wat er co ntent s , mi cro b ia l li mits; O ral l iq uids –
un if ormit y of d osa ge un its , p H, micro b ia l li mit s, a nt imicro b ia l p rese rva tiv e con t ent,
an ti-o x id ant p res ervat iv e cont ent , ex t ra ct ables , a lc oho l cont ent , diss o lu t ion p articl e
size d ist rib u tion , r ed isp ers ib il it y, rh eo lo gical p rop erti es , sp eci fic g ra vit y,
recon st it ut io n t ime; P arent era l p ro ducts – u nifo r mit y of dos age un it s , p H, s teri lit y,
en dot ox ins , p yro g en s, p arti cu la te mat ter, wat er con t en t, an t imicrob ia l p ers ervat iv e
co ntent , an tiox ida nt p ers ervat iv e co nt ent, ex tr act ab les , funct iona lit y t es t ing o f
deliv er y s ys t ems os mo lar it y, p art icle s iz e d is tr ib ution , red is p ers ib i lit y an d
recon st it ut io n t ime. De cis io n t rees fo r accep ta nce cr it eria – New d ru g s ub s tan ce,
degra dat ion p ro duct , p art icle s iz e.
SECTI ON-D
Process ing o f T ab lets : T yp es of t ab les , g ran ulation -man ufa ct u re o f granu les , th eir
b a sic cha ract erist ic an d p ro p erti es with refe rence t o d if fe rent t yp es o f sub st ances.
Vario us a ddit iv es in clu d ed in fo rmu la t io n of ta b lets , Co mp ress ion o f t ab let s
co mp ress ing mach in es a nd t hei r too ling, p rocess ing p rob lems and t he ir re med y,
st an dardizat io n and ev aluat io n o f ta b lets a s p er o ff icial sta nda rds .
69
Coa ting of ta b let s : Pr in cip les and eq uip ment ; T as te mas kin g s uga r coat ing; t ens ile
st rengt h of f il ms, evaluat io n o f co ated ta b let s , d efects o f fi lms .
Process ing of cap s ules : Hare g elat in cap s ules , mat er ia ls and p ro duct i on, fi ll in g
eq uip ment , ha nd fill in g , s emi-aut oma ti c and au toma tic fi ll in g op erat io ns, for mu la ti on,
fin ish ing an d eva luat io n . So ft gela t in cap s ules , man ufa ct uring p roces s, n at ure e o f
ca p su le sh ell a nd cont en ts , p hys ical st ab il it y, p acking a nd eva lua tion .
Mic ro en ca p su la tion : It s imp ort ance and ap plica t ions in p harmaceut ica l formu lat io ns,
t ech n iq ues a nd eq u ip me nt for mi cro eneap s ula tion .

Pha r ma ceutica l C he mis tr y (Spe cia l) Pa per XX
Time: 3 Hr s
Ma x. Ma rks : 6 0 +20(I A)

ca ndidat es a re req uired t o at temp t five q uest io ns in all s elect ing at l eas t one q u e st ion
SECTI ON-A
Hea t T ran sfer: Int rodu ct ion , mo d es of hea t t rans fer, Four ier's la w of h eat flo w,
t her mal con du ct iv it y, s t ea d y st ate co nduct i on. Eq uip ment s : Fi nned t ub e (ex t ende d
su rface ) heat ex ch anger, p lat e hea t ex ch ang er, s p iral heat ex cha nger , sc rap ed hea t
ex cha nger and ai r co o led hea t ex chan ger .
Dist il la tion : Introd u ct ion , vap o ur – l iq uid eq uilib riu m, p a rt ia l vap o rizat ion , p a rt ial
co ndensa t ion, v o la t i lit y, re la tiv e vo lat il it y, meth ods o f d is ti llat io n fo r t wo co mp o nen t
syst ems– fract io na l d ist illat ion , a zeo trop ic d is t i llat io n , st ea m d is t i llat ion, ex tract iv e
dist il la tion .
Filt ra tion : Int rod uct io n , clas si ficat io n o f fi lt ers, p lat e & frame fi lt er p res ses , ca ndl e
filt er, fi lter med ia , fi lt er ai ds, wa sh ing of fi lt er cakes, filt ration th eor y – co nst ant
p res sure f iltrat io n, con st ant ra te fi lt ration , filtrat io n cycl e, cen tr if uges , b a tch top
driv en centr if uge , b a tch u nd er driv en c ent rifu ge, d is k t yp e cen tr ifuge .
SECTI ON-B
70
Dr yin g : In t roduct ion , rat e of d ryin g, con st ant rat e p erio d , crit ica l mo is tu re con t ent,
fall ing rat e p er iod , eq ui lib riu m mo istu re, fr ee mo ist u re , b ou nd and un b oun d mois tu re,
dr yi ng eq uip men ts – t ra y dr yers , dru m d ryers , rot ary dr yers , sp ray dr yers , flas h
dr yers.
Cryst a lliza tion : Int rod uct io n , su p ersa turat io n , mod es of gen erat io n o f sup ers at ura tion ,
nu cleat io n, p rimar y nu cl eat io n , second ary nuc leatio n , crys ta l g ro wt h , L la w o f
cyrs tal gro wth, gro wt h ra te a nd gro uth coeffi ci ent s , c rysta ll is at io n eq uip men ts – T an k
cr ys tal l ize rs , ci rcu la ting magma – vaccum cr yst al lizers , c ir culat in g l iq uid evap ora to r
cr ys tal l ize rs .
Flu id Flo w: In trodu ct ion , N e wto n ian and non -Ne wton ia n flu ids , vis co s it y, e ff ect o f
t emep rat ure o n v is cos it y, k ine mati c vis co s it y, laminar a nd tu rb u lent flo ws , Reyn o ld s
nu mb er , Bernou ll is eq uat ion wit hou t fr ict ion , o ri ficemete r, v ent uri met er , p ump s, t yp es
of p ump s
SECTI ON-C
Reacto rs: Int rodu ct io n to react o r des ig n , ideal b at ch react or , s p ace t ime , s p ace
veloc it y, s t eady s tat e mix ed flo w react or , st ead y st ate p lu g f lo w r eacto r
Chemical p rocess d evelop ment : P roc ess d es i gn develop ment, t yp es of des ig n p ro ces s
develop ment , p lan t loca ti on, p lan t layo ut , p lant op era tion and cont ro l, mat eria l
ha ndl in g.
Sa fet y and los s p reven tat ion : Healt h a nd sa fet y haz ards, s our ce of ex p o sure, ex p os ure
ev aluat io n, ex p os ure ha zard con trol , fi re an d exp los io n ha zard, s afet y regu la ti on, los s
p revent ation .
SECTI ON-D
Chromat og rap hic t ech n iq ues : P rinc ip les o f s ep ara tion, a p p licat ion s and recen t tr end s
in ch ro mat ograp h y:
Column , Pa p er, T hi n layer and ga s chr oma t ograp h y, HPLC , HP T LC, Size ex c lu s io n
ch ro ma to gra p hy, A ff in it y chr omat ograp h y, Io n-ex chang e chr omat ograp h y
Bio lo g ica l S tan dardizat io n : B ioas sa y a nd Radioi mmuno ass ay: E L ISA ,
radio i mmu noa ssa y of drugs l ik e D ig it alis & i ns ul in
Bo o ks Re co mme nded
1 . Coo p er an d G u nn’s D is p en sing for Pha rma ceu ti cal St ud ent s, Ed.S .J. Ca rt er,
CBS p ub lish ers & Dd ist rib ut ors.
2. Coo p er a nd G unn ’s , T ut orial Pharmacy .
3. L.Lach man, “T heory a nd Pra ct ice of In dus tr ia l Pha rmac y” Lea & Fab iger.
4. Ben tl ey and Drive rs, “ A tex t b ook of Pha rma ceu t i cal Ch emis tr y” , O x ford
Press .
5. ISO Rep orts .
6. Indian P harmaco p oeia, G ov t. of In d ia , Min is tr y of H ea lt h a nd Fa mil y
Welfa re.
7. Brit is h Pharmaco p oe ia .
8. Indian Pat en t A ct .
9. Sh arma P.P. , G MP, Va llab h p raka shan.
71
10 . A. O s ol, “ Remi ngt on ’s Ph arma ceu t ical s cien c e”. Mack Pub lis h ing co mp any .
11 . Introdu ct io n t o Chemica l E ng ine ering , B edg er et al. , M cG raw H il l.
12 . Unit O p erat ions o f C h emi cal E ng in ee ri ng, M c. Cab le & S mith
13 . Han db oo k of Che mical Eng in eer in g b y p arry.
14 . Prin cip les a nd met h ods o f P harmacy man ag ement , Harrg , A.; s mith Loa &
Feb ig er , Ph i la delp hia.
15 . Mat eria ls man agement b y G o p alkr is hna, P ren tice Ha ll , In d ia.
16 . W.d . Mc Cab e. J.C. S mit h & P. Ha rriot t, Unit O p erat io ns o f ch emica l
Rea ct or Des ig n and O p erat ion.”
17 . K.R. West ret erp , W .P . M. S waai j, AACM , Beana ckers , “ Chemi ca l R eacto r
Des ig n and O p erat iof” .
18 . W.L .Bad ger a nd J .T . Ben chard, In t rodu ct io n to ch emi cal En g in eer in g , M c
G raw H i l l.
19 . Max p eters, “ Elemen tar y ch e mical En g in eer in g”.
20 . D.G . Jo red en , “ Chemica l Pro ces s D ev elo p ment ” -Pt .l .
21 . M.S . Pete rs & K.D . T immerha ns, “ P la nt Design a nd Econ o mi cs fo r
ch emica l E n g ineers” .
22 . G rogging , P .H. (ed ) Un it Pro ces s in O rgan ic synt h es is ”. -M cG raw H il l.
23 . Sh rev e, R .N .,”Ch emica l P roc ess Indu st ri es” McG raw H i ll .
Refer ence b oo ks
Cou ls on & R ich ard son , “ Chemical En g in eer in g.
72
M.Sc. Che mis tr y (Fi na l) Se me ster II I & I V

Ino rga nic C he mis tr y P ra c tica l P a per s-XXI, XXI I a nd XXII I
Ti me: 1 8 Hr s
(Six s es sio ns, spr ead ov er 3 day s to a ll pa pe rs )
PAPER X XI
Ma x. Ma rks : 8 0 +20(I A)
Pr epara tio ns
Prep a rat ion of select ed ino rga nic co mp ou nds an d t heir st udy b y s p ectros cop ic
met hod s (IR, NMR, EPR et c)
1 . Chlorop enta ammin ec ob alt ( III) Ch lo rid e.

2 . Nitr o/N it ritop ent aa mmine cob alt (III) Ch lor ide (D is ti nct io n b etween n itro an d
nitr it o b y IR )
3 . Prep a rat ion of T in(IV ) Io d id e and T in( II) Io d id e (Ref In organ ic s yn t h es is 1 9 53 , 4 ,
11 9 ).
4 . Po tas sium tr iox olato fe rrate ( III)
5 . Chromou s aceta te
6 . Met al comp l ex es of d imet h yl su l fo x id e (IR): CuC l 2 .2 DMSO , RuCl 2 .4 DMSO
[J.Chem. Ed uc., 1 9 82 , 5 9 , 57 ).
7 . Cis and t ra ns [Co (en ) 2 C l 2 ].
8 . T ris (acet yl -acet ona to) ma nga nes e(III).
9 . Bromin at ion o f Cr( III) ac et ylaceton at o C r(a cac) 3 . [J.Ch em. Ed u . 1 9 86 , 6 3 ].
10 . Sep arat ion o f op t ical iso me rs o f c is [Co (en ) 2 C l 2 ]C l : J .Che m So c. 1 960 , 4 369 .
11 . Prep a rat ion and u s es o f Ferro cen e . J .Che m. E du. 1 9 66 , 43 , 7 3; 1 976 , 5 3 , 7 30 .
73
12 . Prep a rat ion of co p p er gly cine co mp lex -c is a n d trans b is(gl ycina to Cu( II); J . Ch e m.
So c. Dalt on 1 979 , 1 90 1 ; J .Chem E du . 1 982 ,59 , 10 52 .
13 . T ris (acet ylaceton at o) co b alta te ( II I).
14 . T ris (T h iou rea ) Cop p er(I) S ulp hat e. (Est ima t ion of Cu - Iod omed tr ica ll y) An y ot h er
co mp oun d p rep ared in t h e lab .
I Pr epa ra tio n 5 5 Ma rks
II La b. Reco rd 1 5 Ma r ks
III V iv a -v oce 1 0 Mar ks
PAPE R X XI I
Ma x. Ma rks : 8 0 +20(I A)
Ins tru menta tio n
1. Sp ect ro p hot omet ric D et ermin at ions

2. Con ductometr ic T it rat io ns
3. Flame Ph oto metr y
4. Po ten tio met ric/ p H-ana lys is
5. El ect ro gravi met ri c An a l ys is
6. Po larograp hic a nal ys is
7. Any ot h er te chn iq u es introdu ced
I I ns tr ume nta tio n 5 5 Mar ks
II La b. Re cor d 1 5 Ma r ks
III V iv a -v o ce 1 0 Ma r ks
P APER X XI II
Ma x. Ma rks : 8 0 +20(I A)
Q ua ntit ative an al ys is o f elemen ts or group s in th e co mp lex es , mix tu res, or es,

allo ys et c. b y ava ilab le ana lyti cal t echn iq ues .
I Q ua nt ita tiv e a na ly sis 5 5 Mar ks
74
II La b. Re cor d 1 5 Ma rks
III V iv a -vo ce 1 0 Mar ks
Boo ks Sug ges ted
1 . Synth es is and Ch ara ct eriza tion o f Inorgan ic co mp oun ds W.L . J o l ly, P ren t ice Ha l l,
Eng lo wood.
2 . Synth es is a nd P h ys ica l Stu dies o f Inorga nic C omp ou nds , C .F.Bel l, Perga mo n
Press .
3 . A T ex t Book of Q u ant it at iv e Ana l ys is; A .I. V oge l, E LBS. Lo ndon .
4 . Inorgan ic Prep a rat ions ; W.G . Pa lme r
Or
M.Sc . Che mis try (Se mester I II & I V )

P hy s ica l C he mistry Pra ctica ls Pa per -XXI, XXII a nd X XI II
Ti me: 1 8 Hr s
Ma x . Ma rks : 8 0 + 20(I A) , 8 0 +20(IA) & 8 0 +20(I A)
Pa per XXI
Po tentio metry
1. Det ermin at ion o f a ct iv it y co ef ficient of Ag + in a so lut io n o f s ilv er n it ra te an d
t o s tud y t h e effect o f p ot as siu m n it rat e o n t he act ivit y co ef fi cien t o f s ilve r
nitrat e.
2. Det ermin at ion of t he cel l Pt , H 2  HCl A gCl Ag wit h v ar iou s co nc ent ra tions o f
HCl a nd to ob ta in t he act i vit y coe ff ic ient o f HCl .
3. Det ermin at ion of s o lub i lit y o f s i lv er hal id es i n wat er.
4. Det ermin at ion of f irst and s econ d ion iz ation co nst an t of p h osp horic ac id .
5. St udy o f si lv er-ammon ia co mp lex and d etermin at io n o f th e s ta b i lit y co nst an t.
6. Det ermin at ion of s tren gth of fer ro us a mmon iu m su lp hat e us in g p o tas sium
dichro ma te o r c er ic su lp hat e and d eterminat io n o f redox p o tentia l.
7. Det ermin at ion of s tren gth o f HCl and CH 3 CO O H in a mix ture us ing Na O H.
8. T itrat ion o f weak/ st ro ng ac id with st ro n g b as e us in g q uinh y dro n e an d
determinat io n o f d isso ciation co nst an t of t he acid .
9. St udy o f eq u il ib riu m con sta nt o f th e react io n Fe + + + + Ag  Fe + +
+ Ag + .
10 . T o determin e th e d egr ee o f h yd ro l ys is o f a nil ine h yd roch lo ride.
75
11 . T itrat ion o f hal id es with Ag NO 3 ind iv idua ll y and in the mix t ure o f t wo ha lid es .
12 . Det ermin at ion of l iq ui d jun ct ion p o tent ial .
Che mica l Kine tics

13 . Det ermin at ion o f v elo cit y co nst ant o f the reaction o f et h y l acetat e wit h NaO H
an d act iv ati on energ y and t emp era ture coe ff icient of t he r eacti on.
14 . Det ermin at ion of t he v elo cit y co nst ant a nd en erg y o f act ivat io n o f th e rea ct ion s
b etwe en H 2 O 2 a nd H I.
15 . Inves t iga tion of t he react io n b et ween a cet on e a nd iod in e ( wit h resp ect t o H + , I 2
an d aceton e).
16 . Det ermin at ion of th e o rde r a nd v elo cit y o f th e react ion b et ween p o tas sium
p ers ulp hat e and p ota ss ium io d ide.
Exp eri ment Ma rks : 5 5
Lab r ecor d & V iv a -vo ce Ma rks : 1 5+10
Boo ks Sug ges ted
1. Pract ica l P h ys ica l Che mis tr y, A.M. Ja mes and F.E . Pr ichard , Lo ngma n .
2. Find ley ’s Pract ical P hys i ca l Che mist ry , B.P. Lav it t, Long ma n.
3. Pract ica l P h ys ica l Che mis tr y, S .R. Pa lit and S. K. D e, Scien ce.
4. Exp erimen ta l Ph ys ical Ch emis tr y, R .C. Da s a nd B . B eh era , T at a McG raw H i l l.
Pa pe r XXII
Co nducto metry
1. Det ermin at ion o f t h e eq u iv alent co ndu cta nce of weak ac id (b enz oic a nd aceti c
acid ) at s everal con cent ra tions a nd th e d is so cia tion co nst ant of t he acid.
2. Det ermin at ion of t h e eq uiva lent cond u ct an ce of s trong el ect ro lytes su ch a s HCl,
KC l , KNO 3 an d Na Cl an d t he v alid it y of O nsa gar eq uat ion.
3. Det ermin at ion of s o lub i lit y o f s i lv er hal id es .
4. St udy o f deg ree o f h ydro l ys is of a nil in e h yd roch lorid e.
5. Con ductometr ic t itrat io n of : ( i) St ron g acid v s. st ro ng b a se,
(ii ) Strong ac id vs . wea k b ase, (i ii ) W eak ac id vs . st ro ng b as e, ( iv) W ea k acid
vs . wea k b ase, (v ) CH 3 CO O H + HC l vs . NaO H, (v i) MgSO 4 v s . BaC l 2 .
6. Det ermin e t h e crit ica l mice lle con cent ra t io n (CMC) o f a s ur facta nt (s od iu m
laur yl s ulp hat e) b y cond u ct iv it y meth o d.
pH-metr y
7. Prep a rat ion of b uffer s ol ut io n o f var io us p H and th e d et ermina t ion o f t hei r p H

va lues .
8. p H-titrat io in s o f: (i ) A cet ic a cid v s. NaO H, (ii ) h yd roch lo ric acid v s . NaO H,
(ii i) a cet ic a cid v s . a mmo n iu m h yd rox id e an d (iv) HC l vs . NH 4 O H.
9. Det ermin at ion of t he d eg ree of h ydro lys is of an il in e h ydro ch lor id e.
76
10 . T o find d iss o ciat io n con st ant s o f wea k acids .
Co lo rimetry / Spe ctropho to me tr y
11 . Ver ificat io n of th e Lamb ert -B eer ’s la w u sing so lut ion s s u ch as K 2 C r 2 O 7 ,

CuS O 4 , KMnO 4 in wat er a nd I 2 in CCl 4 .
12 . St udy o f iron-t i ron a nd iron -sa licyl ic a cid co mp lex es .
13 . Det ermin at ion of t he co mp os it io n of va rious mix tu res sp ect rop h ot omet rical l y:
(i) Pot as siu m d ich ro ma te an d p ota ssiu m p ermang ana te (i i) Cr yst al v io let an d
au rine
14 . Det ermin e t he d iss ociat io n con st ant o f an in d icat or sp ect ro - p ho to metr ical ly.
Boo ks Sug ges ted
1 . Pract ica l P h ys ica l Che mis tr y, A.M. Ja mes and F.E . Pr ichard , L ong ma n.
2 . Find ley ’s Pract ical P hys i ca l Che mist ry , B.P. Lav it t, Long ma n.
3 . Pract ica l P h ys ica l Che mis tr y, S .R. Pa lit and S. K. D e, Scien ce.
4 . Exp erimen ta l Ph ys ical Ch emis tr y, R .C. Da s a nd B. Beh era,M cG ra w H i ll.
Pa per XXII I
Die le ctric C o nsta nt a nd D ipo le Mo me nt
1. Det ermin at ion o f d iel ect r ic co nst a nt s of s ome org an ic liq u ids an d co mp os it ion
of u nkn o wn mix t ures .
2. Det ermin at ion of d ip ole mo ment s of so me org anic liq u ids .
Po la rogra phy
3. T o determin e d isso lv ed ox ygen in a q ueous s o lu t ion of o rga n ic s o lven t.
4. Det ermin at ion of ha lf wa v e p ot ent ials o f so me ca t ions i n a q ueous an d in non -
aq ueo us so lut io ns .
5. Det ermin at ion of h al f wave p otent ials of ions in mix tures .
6. Amp ero met i rc t it ra tions invo lv ing : ( i) P b (NO 3 ) 2 v s. K 2 Cr 2 O 7 and (ii) Pb (NO 3 ) 2
vs . K 2 S O 4 .
Po la r imetry
7. Det ermin at ion of r elat iv e str en gth o f acids b y t he st ud y o f in vers ion o f s ucr ose .
8. Det ermin at ion of ve lo cit y con st ant of mu ta rot at io n o f g lu cos e i n th e p res enc e
of a cid o r alka l i.
77
Inter fe rro metr y

9. Det ermin at ion of s p eed o f so und of p ure l iq uids/ mix tures u s ing in terferromet er.
Fla me Pho to metry :

10 . Det ermina tion of Na + , K + Ca 2 + a nd Mg 2 + i n ta p wa ter, ju ice, elect ra l et c.
No te: Any ex p eri men t ma y b e in t rodu ced / deleted in t he p racti ca l cla ss b as ed o n

th e ava ilab i lit y/n on-ava ilab ilit y o f th e ins tru men ts / ch emi cals .
Boo ks Sug ges ted

1 . Pract ica l Ch emist r y, A .M . Ja mes an d F.E . Pri che rd , Long man.
2 . Pract ica l P h ys ica l Che mis tr y, B .P. Lev it t an d Z ind le y’s , Lon g man .
3 . Pract ica l P h ys ica l Che mis tr y, S .R. Pa lit and S .K. D e, Scien ce Book Ag enc y.
4 . Exp erimen ta l Ph ys ical Ch emis tr y, R .C. Da s a nd B. Beh ra , M cG raw H il l.
5 . Exp erimen ts in Phys ical Ch emis tr y, Sh oema ker a nd G aila nd McG ra w H i ll .
6 . Syste mat ic ex p erimen tal Ph ys i cal Che mis t r y, T .K. Cha nde rs hekh ar & S.K.
Rajb h oj
7 . Exp erimen ta l P h ys ical Ch emist ry, V .D .Ath awa le and Parul Mat hur, N ew Ag e
Interna t iona l.
Or
M . Sc Chemis try (F ia nl) Semes te r IV
Orga nic C he mistry Pr a ctica ls Pa per -XXI , XXII a nd X XI II

Ti me: 1 8 Hr s
Ma x . Ma rks : 8 0 + 20(I A) , 8 0 +20(IA) & 8 0 +20(I A)
Pa per XXI
1. Q ua lita tiv e Ana ly s is : Sep a ra tion o f comp ou nds of a b ina ry (l iq u id - liq u id,
l iq u id -so lid o r so l id-s o l id) o rgan ic mix t ure us ing p hys ical and ch emi ca l
met hod s a nd characte rizat io n of t he co mp o nen ts wit h t h e help o f chemi cal
78
an alys is a nd con firmat io n o f t heir st ru ctu res with th e h elp of IR and PMR
sp ect ra l da ta (IR & PMR sp ect ra t o b e p rov id ed ).
Boo ks Sug ges ted
1. "A Han db oo k of O rg anic A nal ys is Q ua lita t iv e an d Q u ant it at iv e" b y H.T . Clark e

an d rev is ed b y B .Ma yn es, Ed ward A rno ld (Pu b .)., Lt d . Lon don , 1 97 5 ).
2. "S yst ema ti c Q ua lita t ive O rga n ic A na lys is " b y H.M id d leton , E d ward A rno ld
(Pub lis h ers) L td ., Lo nd on 1 9 59 .
3. "A T ex t Bo ok of P ra ct ica l O rga nic Ch emis try inc lud in g Q ua lita ti ve O rg an ic
Ana lys is " b y A rt hu r I. Vo gel , Lon g mans G reen and Co . , Lt d . , Lon don 1 9 6 6 .
4. "E lement ary Pract ica l O rgan ic Che mis tr y" b y Art hur I. V og el, C BS Pu b lis h ers
& D is tr ib u tors.
5. "A G uid e t o s p ectros cop y in O rg an ic Chemist ry' b y PA VY
6. "S p ectro met ric Id ent if icat ion o f O rg anic Comp ound s", F ift h Ed . , R.M.
Silv ers t e in , G .S . Bas sl er an d T .C.Morr ile, J o hn W i ley a nd Son s , Ne w Y ork .
7. "O rga nic S p ect ros cop y', 3 r d Ed ., b y Wi ll ia m Ka mp . J ohn W iley & S ons .
8. "S p ectros cop ic" Met hod s in O rgan ic Che mis t r y, D .H . Wi l liam & Ian F lemin g .
9. Vog el's T ex t Bo ok o f P ractica l O rga nic C hemis t r y b y B.S. Furn ers et. a l.,
Lon gman G roup Lt d .
Pa pe r XXII
1. Pr epara tio n o f Or ga nic Co mpo und s: Prep arat ion of O rga n ic Comp ound s
invo lv ing t wo o r th ree s ta ges ; Is o la tion an d p urif icat ion o f n at ura l p rodu cts .
2. Tec hnique s o f P ur ific a tio n a nd Sepa ra tio n ; S epa rat ion o f mix t ures u s ing
T LC, vacuum d is t i llat ion and s ub l imat ion .
Boo ks Sug ges ted
1. T ex t Book of Vog el's Pract ical O rg an ic C h emist ry b y Long ma n G roup , B.S.

Fu rness et a l. , Lt d.
2. "E x p eriment s in O rg an ic Chemist ry" Lo u is F . Fies er O .C . Heath a nd Comp an y
Bos to n, 1 9 55 .
3. "O rga nic S ynt h es is " Co llectiv e Vo l. I.
4. 'Lab o ra tory Ma nua l in O rganic Che mis tr y' by R. K. Bans al, W iley Eas tern Lt d .,
New Delh i -1 9 80 .
79
Pa per XXII I
1. Q ua ntita tiv e estima tio n o f t he fo l lo w ing
Amino g ro u p , hyd rox yl group , a cet ox y gr o up , carb onyl g ro u p , uns at ura tion,
redu cin g a nd non -r edu cin g sug ars , sa p on if ica tion va lu e a nd io d in e va lue o f fat s
an d oils , for ma lin an d g ly cin e
2. Co lo rimetric determi na tio n o f the fo llo w ing
Carb oh ydrat es, ascorb ic a cid , a mino a cids , p rot eins , cho l es tero l u rea.
Boo ks Sug ges ted
1. "E lement ary Pract ica l O rgan ic Che mis tr y b y Arth ur I. Vo ge l L ong mans , G ree n
an d Co. 1 9 58 .
2. "An Int roduct ion t o Practi cal Bio che mis t r y", b y D avid T . Plu mmr, T at a
McG raw H ill Pub lish ing Co mp any, Ltd ., N . Delh i, 1 988 .
3. Pract ica l O rgan ic Ch emis tr y' b y Ma nn and Sa und ers .

Pha r ma ce utica l C he mistr y Prac tica ls
Pa pe r-XXI, X XI I a nd XXII I
Ti me: 1 8 Hr s
Ma x . Ma rks : 8 0 + 20(I A) , 8 0 +20(IA) & 8 0 +20(I A)
Pa pe r- XXI
1 ) P rep ara tions of organ ic co mp oun ds o f med ic in al inte rest .
2 ) T echn iq ues of Purif ica tion .
3 ) S ep arat io ns and id ent if icat io n o f co mp one nt s o f b ina ry organ ic mix t ure u s in g
chemica l meth ods a nd sp ect ra l dat a.
Boo ks Sug ges ted

1. "A Han db oo k of O rg anic A nal ys is Q ua lita t iv e an d Q u ant it at iv e" b y H.T . Clark e
an d rev is ed b y B .Ma yn es, Ed ward A rno ld (Pu b .)., Lt d . Lon don , 1 97 5 ).
80
2. "S yst ema ti c Q ua lita t ive O rga n ic A na lys is " b y H.M idd leton , E d ward A rno ld
(Pub lis h ers) L td ., Lo nd on 1 9 59 .
3. "A T ex t Bo ok of P ra ct ica l O rga nic Ch emis try inc lud in g Q ua lita ti ve O rg an ic
Ana lys is " b y A rt hu r I. Vo gel , Lon g mans G reen and Co . , Lt d . , Lon don 1 9 6 6 .
4. "E lement ary Pract ica l O rgan ic Che mis tr y" b y Art hur I. Vog e l, C BS Pu b lis h ers
& D is tr ib u tors.
5. Introdu ct io n t o Sp ectroscop y : G uid e fo r Stu den ts of O rgan ic Ch emis t r y b y D .L.
Pa via , G ary M. Lamp ma n , G eo rg e S . Kriz, D . L. Pa n ia.
6. "S p ectro met ric Id ent if icat ion o f O rg anic Comp ound s", F ift h Ed . , R.M.
Silv ers t e in , G .S . Bas sl er an d T .C.Morr ile, J o hn W i ley a nd Son s , Ne w Y ork .
7. "O rga nic S p ect ros cop y', 3 r d Ed ., b y Wi ll ia m Ka mp . J ohn W iley & S ons .
8. "S p ectros cop ic" Met hod s in O rgan ic Che mis t r y, D .H . Wi l liam & Ian F lemin g .
9. Vog el's T ex t Bo ok o f P ractica l O rga nic C hemis t r y b y B.S. Furn ers et. a l.,
Lon gman G roup Lt d .
Pa pe r-XXI I
1 ) Prep a rat ion and e valuat ion o f t h e fo l lo win g :

Emu ls ion , s imp le syrup , a q ueous idodin e s o lut ion , st ro ng iod in e s o lu t ion , cala min e
lot ion , b oro g l ycerin e, lann ic ac id/ g l ycerin e, p heno l/ g l ycerin e, p ip ermint wat er , ros e
swa te r, n on-st a in in g iod in e o int min d cum meth yl s a licy la te, fo r mu lation of s imp le an d
med icated o in tmen ts , magn es iu m h yd rox ide mix tu re ( milk o f magnes iu m), s imp le an d
co mp lex p owd ers .

Pa per-XXII I
(i) Det er min ation o f s p ec if ic rot at ion of ib u pro fen a nd det er min ation o f its p ercen tag e
in t he un kno wn s amp l e.
(ii ) Vo lumet ri c d et ermina t ion of ib up rofen in the g iven tab let.
(ii i) Sp ect ro p ho tomete r d et er mina tion of a sp irin con tent in t h e s o lu b l e a sp ir in t ab le.
(iv ) S p ect rop ho to met er det er min ation of Paracetamo l in t h e t ab let .
(v) Det er mina tion o f V ita min C in g iv en for mu la tion .
(vi) Det erminat io n of p henob arb ilone in th e g iv en cou gh s yrup .
(vii ) T o p erform I.P. mo n ograp h o f ta b let
(vii i) to p erfo rm I.P . mon og rap h of hard gela t ine cap s ule.
(ix ) Det erminat io n of Ch lora mp heni co l in g iv en ca p su le.

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1

1. Prof. Biman Bagchi

3. Prof. Ashok Mukharjee

6. Prof. Ashok Kumar Prasad

7. Prof. Isabel Rozas

9. Dr. Deepak Chopra

1. Panjab University, Chandigarh

V Inorganic Chemistry (General) 60+20 3 hrs.

XXI Inorganic Chemistry Practicals 80+20 18 hrs.

Tutorials 1/2 hr. per paper per group

M .Sc. Chemistry (Pre vious)

Sy mme try a nd Gro up The ory i n C he mistry

Stereochemis tr y a nd Bo nding i n Ma i n Gro up Co mpo und s

Meta l-Lig a nd Equil ibr ia i n So lutio n

Meta l-Lig a nd Bo nding

Boo ks Sug ges ted

M .Sc . Chemistry (Pre vio us) Se me ste r I

Rea l Ga se s: Co ncep t o f Fug a city a nd Ac tiv ity

Pa rt ia l molar q uan tit ies , ch emical p ot ent ia l an d G ib b s -Duhem eq ua tion,

Sur fa ce Che mistry a nd Ca ta ly sis

Study o f surfaces b y ST M, SEM. He terogeneou s catalysis, surfac e

Boo ks Sug ges ted

M.Sc. Che mis try (Prev io us) S e mes ter I

No te: Eight q ues tio ns wi ll b e s et, t wo fro m each of t h e se ct ion s A , B, C & D . T h e

Rea ctio n Mec ha nis m: Struc tur e a nd Rea ctiv ity

T yp es o f mech an isms , t yp es o f react io ns , th er mod yn a mic and ki net ic

M echa nis m of Nuc leo philic Alip hatic S ubstitution

M echa nis m of E liminatio n Reac tions

Elementary idea of principle cate gories of as ymmetric synthesis, Cram’s rule

Stere oche mistry o f d ecalins,

Che mical correlation of c onfiguration -de termination of re lative c onfigu ratio n o f

M.Sc. Che mis try (Prev io us) Se mes te r I

Cel l Struc tur e a nd Meta bo lis m

Ca rbo hy dra tes

St ructure a nd b io log ica l fu n ct ion s o f St ru ctu ra l p o lysaccha rid es - c el lu los e a nd

Het erop ol ys acchar id es-g lu co saminog lycans or mucop o lys acchar id es .

Pro p erties o f l ip id aggreg ates- micell es , b ilayers , lip o somes an d th ei r p o ssib le

Lip id met ab olis m - β-ox ida tion o f fatt y acids .

A mino -a cids, P ept ide s a nd Pro te in

Es sen t ial a mino a cid s, Is oe le ct ri c p H,chemi ca l and enzyma t ic h yd ro l ys is of p rot eins t o

Nuc le ic Ac ids a nd Ge net ic Co d e

St ru ctu re of n ucl eot id es , nu cleo s id es , DNA (Wa ts on -Crick mode l) RNA st ru ct u re an d

St udy o f pr o ka ryo tes

Boo ks Sug ges ted

3 . Bioch emis tr y, J . David Rawn , Nei l Pat ters on .

4 . Bioch emis tr y, Vo et an d Vo et , Jo hn Wi ley.

5 . O ut lin es o f B io che mis tr y, E. E .Co nn and P. K. St ump f, Joh n W i le y.

M.Sc. Che mis try (Prev io us) Se mes te r I

No te: Eight q u est io ns wil l b e s et, t wo f ro m s ect io n A and t hre e fro m ea ch of th e

Ex a mp les of sca la r a nd vectors , d efin it ions of ve ct ors in t wo , t hree s p aces ,

Ma tric es a nd De te rmina nts

Def in it io n o f matr ix , t yp es of ma trices , v iz . ro w mat rix , co lu mn ma tr ix ,

Need for lo garit h m in ch emist ry. T h eo r y a nd app licat ion o f logar it h ms fo r

Gra phica l Re pre senta tio n o f Equa tio ns

Eleme nts o f A lg eb ra ic a nd Trigo no metric Funct io ns

T he b inomial ex p ans io n, so me ex amp le from che mist r y, s in es , cos in es a nd

Di ffere ntia l Ca lc ulus

Di ffere ntia l Eq ua tio n

Boo ks Sug ges ted

M .Sc . Chemistry (Pre vio us) Se me ste r I

No te: Eig ht q u est ions wi ll b e s et , t wo wi ll b e set fro m s ect io n A an d t hr ee fro m each

Boo ks Rec o mmende d: