PHARMACOLOGIC SHEET

DRUG ACTION INDICATION/S CONTRAINDICATIONS ADVERSE EFECTS NURSING

RESPONSIBILITIES
Domperidone Antidopaminergic Symptomatic Contraindicated in Serum prolactin level Teaching points:
(Motillium) Antiemetic management of patients with known may increase resulting in Proper dosing:
1 tab TID upper sensitivity or intolerance galactorrhoea in females Missed dose: Take
gastrointestinal to the drug. (increasing of milk as soon as possible;
motility disorders Domperidone should not production, probably by not taking if almost
associated with be used whenever increasing prolactin time for next
chronic and gastrointestinal production by the pituitary scheduled dose; not
subacute gastritis stimulation might be gland) & less frequently doubling doses.
and diabetic dangerous, i.e., gynaecomastia in males. Obtaining medical
gastroparesis. gastrointestinal CNS: dry mouth (1.9%), attention if fainting,
May also be used hemorrhage, mechanical headache/migraine dizziness, irregular
to prevent obstruction or (1.2%), insomnia, heartbeat or pulse,
gastrointestinal perforation. nervousness, dizziness, or other unusual
symptoms Also contraindicated in thirst, lethargy, irritability symptoms occur.
associated with the patients with a prolactin- (all<1%).
use of dopamine releasing pituitary tumor Gastrointestinal (2.4%):
agonist (prolactinoma). abdominal cramps,
antiparkinsonian diarrhea, regurgitation,
agents. changes in appetite,
nausea, heartburn,
constipation (all<1%).
Endocrinological (1.3%):
hot flushes, mastalgia,
galactorrhea,
gynecomastia, menstrual
irregularities.
Mucocutaneous (1.1%):
rash, pruritus, urticaria,
stomatitis, conjunctivitis.
Urinary (0.8%): urinary
frequency, dysuria.
Cardiovascular (0.5%):
edema, palpitations.
Musculoskeletal (0.1%):
leg cramps, asthenia.
Miscellaneous (0.1%):
drug intolerance.
Laboratory parameters:
elevated serum prolactin,
elevation of AST, ALT and
cholesterol (all<1%).
Extrapyramidal
phenomena are rare in
adults; they reverse
spontaneously as soon
as treatment is stopped.
When the blood-brain
barrier is immature (as in
infants) or impaired, the
possible occurrence of
neurological side effects
cannot be excluded.