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Radiation Risk of Medical Imaging During Pregnancy

Health professional information

Authors: Mr Anthony Wallace*


Ms Anne Hayton *

What is radiation?

Background radiation

Background radiation is always present in our environment. It is inescapable and provides


each of us with a continuous, small radiation dose.
The sources of background radiation in our environment are cosmic rays from the universe,
naturally occurring radioactive substances in the food and water we eat and drink, the air
we breathe, in the ground, in building materials and so on.

The amount of background radiation varies in different parts of the world due to the
radioactivity of the soil, latitude, height above sea level and lifestyle (predominantly indoors
or outdoors). Some countries have background radiation that is 10 times greater than
generally found in Australia.

Every year, everyone living in Australia receives background radiation that is equivalent to
the radiation dose from 50–100 simple chest X-rays.
X-rays are part of the electromagnetic range of energy that includes radio waves, visible
light and gamma rays. Visible light and X-radiation (X-rays) both travel in straight lines and
cast a shadow when they interact with a solid object.

When the path of an X-ray is altered by coming into contact with an object, the X-ray
deposits some of its energy to the object (including the human body). This deposit of energy
is called a radiation ‘dose’.

X-rays, gamma rays and some other high-energy forms of radiation can deposit enough
energy into the human body to change molecules or proteins, which are the building blocks
of the body. These high-energy particles or rays are referred to as ionising radiation, or
sometimes simply as ‘radiation’.

X-rays
X-rays have more energy than visible light and can therefore penetrate much deeper into
and through objects. An X-ray beam is absorbed differently by different structures in the
body. A dense structure, such as bone, absorbs a high percentage of the X-ray beam;
whereas low-density structures, such as soft tissue, absorb a small amount. Metal objects in
the body (such as a swallowed coin, a bullet or a surgical plate used to fix a fracture) will
usually appear as white. Air in the lungs will be black, because it absorbs so little radiation.
These differences in X-ray absorption can be used to create a picture of the different
structures, organs or tissues in the body that allow a radiologist (specialist doctor) to
diagnose and treat disease.

X-rays are electrically generated and are only present when the X-ray machine is switched
on, just like a light bulb. Once the X-ray machine is switched off, there is no residual
radiation coming from the X-ray machine. Having an examination using ionising radiation
does not make people radioactive.

Nuclear medicine

Nuclear medicine is a medical speciality that diagnoses and monitors disease by giving
patients small amounts of a radioactive material, in the form of a ‘radiopharmaceutical’.

A radiopharmaceutical is a combination of a radioactive part and a pharmaceutical (or drug)


part.

After a nuclear medicine test, where a patient will swallow, breathe in or receive an injection
of a radiopharmaceutical, they will be very slightly radioactive for a short time. This small
amount of radiation is picked up by a special camera called a gamma camera (see item on
Nuclear Medicine). The pictures produced by the gamma camera are interpreted by a
nuclear medicine specialist (specialist doctor). The amount of radioactivity that remains in
the body and the length of time a patient remains slightly radioactive depends on the test
carried out (for more information see nuclear medicine).

What tests/procedures are associated with radiation?

Table 1: Types of medical imaging


Types of radiology and nuclear medicine tests, and the use of ionising radiation.

Procedure Uses ionising


radiation?

CT – computed tomography Yes

Fluoroscopy Yes

General X-ray Yes


Radiology
Mammography Yes

MRI – magnetic resonance imaging No

Ultrasound No

General nuclear medicine Yes

Nuclear PET CT – positron emission tomography computed


Yes
medicine tomography

Therapy Yes

Reference:
Wagner L, Lester R, Saldana L. Exposure of the pregnant patient to diagnostic radiations,
2nd ed Medical Physics Publishing, Madison, 1997

What are the risks of having diagnostic imaging during pregnancy for
the mother?

A pregnant woman is no more sensitive to radiation than a woman who is not pregnant. The
risk associated with a diagnostic imaging procedure to a pregnant woman will be the same
for any woman of the same age who is not pregnant (see nuclear medicine).

Women of reproductive age who are referred by their doctor for computed tomography (CT)
scanning, nuclear medicine, angiography and some simple X-ray examinations should let
their doctor and the radiology practice know if there is any chance they may be pregnant.
This may affect decisions about which test to do and whether the test should be delayed
until after a pregnancy test has been carried out.

There are two main types of risk when anyone, including a pregnant woman, is exposed to
ionising radiation:

1. Short-term risk
Examples of short-term (or deterministic) damage include burns to the skin and/or
hair loss on areas of the body that have been exposed to a very large dose of X-
rays. Short-term damage is usually the result of very long and complex CT or
interventional fluoroscopic procedures that are carried out on seriously ill patients.
There is a substantial radiation dose threshold that must be exceeded before short-
term damage occurs. It does not normally occur in diagnostic imaging.

2. Long-term risk
This is also known as ‘stochastic’ risk. There is a very small increase in the
possibility of cancer or genetic damage being caused as a result of medical ionising
radiation.
The amount of risk associated with ionising radiation can be a difficult concept to
imagine, because it is so small. Risk is expressed as chances per million, much the
same way as you would think about the chance of winning the first prize in a lottery,
the chance of dying in a car crash on the way to work or the chance of developing
lung cancer if you smoke five cigarettes.

It is very important to understand that risk cannot be calculated for any individual person
undergoing a procedure involving radiation. Risk estimates refer to large populations of
people and are ‘average’ risks across that whole population. We all have different sensitivity
to the effects of radiation as a result of our genetic or inherited characteristics. For the most
part, we cannot measure or calculate the effect that our genes have on our personal
sensitivity to the effects of radiation.

It is also important to realise that much of our knowledge about the potential small increase
in the risk of cancer that might be associated with exposure to medical sources of radiation,
such as CT scanning and nuclear medicine, is based on data collected from survivors of the
Japanese atomic bombs in 1945 during the final stages of the Second World War, as well
as from people who have been exposed to high doses of radiation from fluoroscopy. From
this data, estimates have been made of the potential risk associated with the far lower
levels of radiation associated with medical tests. These remain only estimates. To date, no
study has been carried out that follows large numbers of people who have been exposed to
CT scanning to see if they actually have a real increased risk of cancer.
Ref: radiation risk of medical imaging for adults and children
What are the risks for the foetus of the mother having diagnostic
imaging during pregnancy?

It is very important to realise that almost all imaging tests expose the foetus to such low
levels of radiation that they are not a cause for concern. However, it is good practice if
possible to avoid those tests and procedures that directly expose the uterus or abdomen to
radiation if a woman could be or is pregnant. As with all medical imaging, the risk to mother
and foetus should be outweighed by the benefit of the test or procedure.

Please note that these comments DO NOT apply to radiation therapy for cancer. Radiation
used for cancer treatment involves radiation doses that are thousands of times higher than
those delivered by diagnostic tests.

In general terms, the risk to the unborn foetus from ionising radiation used for medical
diagnosis (X-rays, CT, nuclear medicine and angiography, for example) is dependent on:

 the part of the mother’s body exposed to the radiation

 the stage of pregnancy

 the radiation dose received

If you are pregnant and you are scheduled to have any kind of medical imaging, you must
tell your doctor and the practice or hospital where you are having the test.

It is understandable that most women who have had exposure to medical sources of
radiation when they are pregnant or who have found out they are pregnant soon after a test
or procedure involving ionising radiation are worried about whether this will affect their
foetus. If you have any concerns at all regarding exposure to medical sources of radiation,
please discuss these with your doctor.

1. 1. Short-term risk
Because the foetus is rapidly growing and developing, short-term risks (or
deterministic risks) are different for a foetus (or embryo, as the foetus is known in the
first 8 weeks after conception) compared with a child or adult. They include death,
slowing of normal growth, abnormal growth (resulting in deformities) and being
intellectually or emotionally underdeveloped. The International Commission on
Radiological Protection (ICRP) has stated that deterministic risks such as these
would not be expected to occur in an embryo or foetus that had been exposed to
less than 100 mGy of radiation.
Table 2 provides an indication of the expected dose of radiation to a foetus or
embryo associated with various examination types. The foetal dose estimates
provided apply only to the early stages of pregnancy when the foetus is small. It can
be seen that even for the highest dose examinations at the bottom of the table, the
expected dose to the foetus or embryo for a single examination is well below the 100
mGy threshold.

2. 2. Long-term risk
This is also known as stochastic risk. As explained above, currently it is only possible
to estimate potential risks. These are the theoretical risks of cancer some time after
birth (as a child or adult) and the risks of hereditary diseases occurring in the
descendants of someone who was exposed to radiation as a foetus.
The scientific information available about the effect of small amounts of radiation on
the fertilised egg before it implants in the uterus (in other words, within hours to days
of conception) and in the first 3–4 weeks after conception is limited. For most
diagnostic radiation exposures of women in the first 3–4 weeks after conception
when the pregnancy is unrecognised, the risks of childhood cancer will be very small
(and probably much smaller than if the exposure had occurred later in pregnancy).

Approximately 1 in every 500 children develops cancer during childhood (even in the
absence of any exposure to radiation as a foetus). For the examinations in the lowest dose
range in Table 2, the estimated potential additional risk (over and above the normal lifetime
risk of developing a cancer) for the foetus is approximately 1 in 1,000,000 and for the
highest dose examinations at the bottom of the table, the additional risk (over and above the
normal lifetime risk of developing a cancer) is thought to be approximately 1 in 1000 to 1 in
200. This means that for a foetus exposed to one of the highest doses of radiation after the
first 4 weeks, the risk of childhood cancer might be increased to 3 in 500.
This is still considered to be a very low risk. If a higher dose examination is needed,
because the risk of not doing the test is very significant for the mother, then this is
appropriate. If a woman has one of the higher dose tests before she knows she is pregnant,
the increased risk to the foetus is still considered to be small. This would not be a reason on
its own to consider pregnancy termination, because of fears about cancer risks for the baby
or child.
Table 2: Typical foetal doses and risks of childhood cancer for common radiology tests and
procedures*
Grouped according to foetal dose, from lowest to highest

Table 2 provides an indication of the expected dose of radiation to a foetus or embryo


associated with various examination types. The foetal dose estimates provided apply only to
the early stages of pregnancy when the foetus is small. It can be seen that even for the
highest dose examinations at the bottom of the table, the expected dose to the foetus or
embryo for a single examination is well below the 100 mGy threshold.
2. Long-term risk
This is also known as stochastic risk. As explained above, currently it is only possible to
estimate potential risks. These are the theoretical risks of cancer some time after birth (as a
child or adult) and the risks of hereditary diseases occurring in the descendants of someone
who was exposed to radiation as a foetus.

The scientific information available about the effect of small amounts of radiation on the
fertilised egg before it implants in the uterus (in other words, within hours to days of
conception) and in the first 3–4 weeks after conception is limited. For most diagnostic
radiation exposures of women in the first 3–4 weeks after conception when the pregnancy is
unrecognised, the risks of childhood cancer will be very small (and probably much smaller
than if the exposure had occurred later in pregnancy).

Approximately 1 in every 500 children develops cancer during childhood (even in the
absence of any exposure to radiation as a foetus). For the examinations in the lowest dose
range in Table 2, the estimated potential additional risk (over and above the normal lifetime
risk of developing a cancer) for the foetus is approximately 1 in 1,000,000 and for the
highest dose examinations at the bottom of the table, the additional risk (over and above the
normal lifetime risk of developing a cancer) is thought to be approximately 1 in 1000 to 1 in
200. This means that for a foetus exposed to one of the highest doses of radiation after the
first 4 weeks, the risk of childhood cancer might be increased to 3 in 500.

This is still considered to be a very low risk. If a higher dose examination is needed,
because the risk of not doing the test is very significant for the mother, then this is
appropriate. If a woman has one of the higher dose tests before she knows she is pregnant,
the increased risk to the foetus is still considered to be small. This would not be a reason on
its own to consider pregnancy termination, because of fears about cancer risks for the baby
or child.

Table 2: Typical foetal doses and risks of childhood cancer for common radiology
tests and procedures*
Grouped according to foetal dose, from lowest to highest

Typical foetal Risk of childhood cancer


Examination type
dose (mGy) per examination
Group 0:
Ultrasound 0 0
Magnetic resonance imaging (MRI)

Group 1:
X-ray skull
X-ray chest
X-ray thoracic spine 0.001–0.01 < 1 in 1,000,000
Mammogram
Head or neck CT scan

1 in 1,000,000
CT pulmonary angiogram
Lung ventilation scan 0.01–0.1 to
1 in 100,000

Group 2:
X-ray of abdomen, pelvis or hip or barium meal 1 in 100,000
CT scan of the chest and upper abdomen
Nuclear medicine scans using technetium-99m 0.1–1.0 to
including: thyroid scan, lung perfusion scan, renal 1 in 10,000
scan (MAG3, DMSA) or white cell scan

Group 3:
Lumbar spine X-ray
Barium enema
Intravenous pyelogram or urogram
CT abdomen or CT lumbar spine 1 in 10,000
Nuclear medicine scans using technetium-99m 1.0–10 to
Bone scan 1 in 1,000
Cardiac blood pool scan
Myocardial scan
Renal scan
Thallium-201 myocardial scan

CT of pelvis, or pelvis plus abdomen


PET-CT 10–50 1 in 1,000
Technetium-99m myocardial SPECT
(rest – exercise protocol) to
1 in 200
Natural childhood cancer
risk:
1 in 500

*Advice from the (UK): Health Protection Agency, the Royal College of Radiologists and the
College of Radiographers

What are the benefits for the mother?

Before referring a pregnant woman for an imaging test or procedure, the woman’s doctor
will consult with her and make an assessment that the benefits outweigh any possible risks.
The radiologist or nuclear medicine specialist carrying out the test or procedure will also
assess if it is the most appropriate test or procedure, taking into account the information the
referring doctor has written on the request form together with the patient’s medical history
(see Radiation Risk of Medical Imaging for Adults and Children)

What if a woman has had a test involving radiation and then finds out
she is pregnant?

If a woman undergoes a radiology or nuclear medicine procedure and then finds out she is
pregnant, it is important the woman talks to her doctor about theoretical risks. This will avoid
needless worry or inappropriate consideration of pregnancy termination as a result of fears
about the wellbeing of the foetus because of exposure to ionising radiation.

It is entirely appropriate that the woman talks to her referring doctor about any worries or
concerns. The information provided in this publication will for the vast majority of women be
reassuring. The information is also designed to inform the discussion about potential risk
between a woman and her doctor.

What should a woman of reproductive age consider if referred for a test


involving ionising radiation?

This depends on the kind of test the woman has been referred for. In Table 2, it can be seen
that the tests have been grouped from lowest to highest in terms of the radiation dose that
is given to the uterus (and if a woman happens to be pregnant, to the foetus in the uterus).
When having any kind of nuclear medicine test or a radiology test or procedure that involves
exposing the abdomen or pelvic area to radiation, it is very important for a woman to know if
she is pregnant.

If a woman is definitely not pregnant (in other words, not sexually active) it is safe to
proceed with the test.

If a woman is definitely pregnant, she must tell her doctor and the practice where she is
having the procedure. Medical staff will assess the potential risk of not having the test and
balance this against the potential risk to the foetus from the radiation. It may be decided that
the procedure can wait until after the baby is born or that another test not involving radiation
exposure of the foetus is more suitable.

If a woman cannot be certain that she is not pregnant because she is sexually active, but
her period is not overdue AND she has been referred for one of the lower dose procedures
involving a dose of less than 10 mGy to the uterus (groups 1, 2 or 3 in Table 2), it is
generally considered safe to proceed without having a pregnancy test.

If a woman’s period is late, she should follow the recommendation for probably or definitely
pregnant patients until she has a pregnancy test and it is negative.

If a woman has been referred for one of the higher dose tests (more than a 10-mGy dose to
the uterus), it is more important to be sure she is not pregnant. A woman may be sure
because she is not sexually active. It is also very unlikely a woman is pregnant if she is in
the first 10 days of the menstrual cycle (from the first day of the last period). If a woman is
sexually active, in her reproductive years (in other words, has not gone through
menopause) and in the last half of the menstrual cycle, it is best not to have a higher dose
procedure without consultation between the radiology practice and the referring doctor. If
the test is not a medical emergency, it is advisable to wait and schedule the test or
procedure after the period starts up to 10 days from the beginning of menstrual bleeding.
The chance of becoming pregnant during this time is extremely low.

The list of tests and procedures provided in Table 2 is not complete. A woman should check
with her referring doctor or the practice or hospital where she is having the test or procedure
about possible radiation exposure to the uterus if she thinks she could be pregnant.

What do I need to consider if I am trying to become pregnant?

Preconception radiation exposure of either parent’s reproductive organs has not been
shown to result in increased cancer or abnormalities of children.
If you are trying to become pregnant, and you need to have a medical imaging test involving
radiation, you need to consider the timing of this test in relation to your menstrual period see
what are the radiology referral guidelines for women of reproductive age?

What if a woman is breastfeeding and needs to have a nuclear medicine


procedure?

When a radiopharmaceutical is given as part of a nuclear medicine procedure, it spreads


throughout the body. Some organs will collect a higher concentration of the
radiopharmaceutical than others, but it will be distributed throughout the body. Some
radiopharmaceuticals can enter the breast milk of nursing mothers and be consumed by an
infant.

Usually, to avoid unnecessary exposure of an infant to the radiopharmaceuticals,


breastfeeding will have to be suspended for a short period of time after the nuclear
medicine procedure. The length of the period of time will depend on the type and amount of
radiopharmaceutical used (see InsideRadiology item on Nuclear Medicine). If breastfeeding
at the time of a nuclear medicine procedure, a woman needs to inform the imaging staff
before the procedure and seek advice from the nuclear medicine specialist as to when
breastfeeding can resume. The facility where the woman is having the test or procedure will
normally be able to provide advice concerning the possibility of expressing and storing
breast milk before the procedure is carried out.

Women due to undergo therapy with radioiodine may find it beneficial to stop breastfeeding
2–3 weeks before receiving therapy. This is because breast tissue that is producing milk will
receive a higher dose of radiation than the breast tissue of a woman who is not
breastfeeding. Again, specific advice needs be sought from the nuclear medicine specialist.

Where can I find more information?

Diagnostic Imaging Pathways


International Atomic Energy Agency (IAEA)
Health Physics Society
Duke University
Perinatology
Centre for Disease Control
Health Protection Agency (HPA)

References:
Wagner L, Lester R, Saldana L. Exposure of the pregnant patient to diagnostic radiations,
2nd ed. Medical Physics Publishing, Madison, 1997.
Wallace A, Cain T. Radiation Risk of Medical Imaging for Adults and Children. Royal
Australian & New Zealand College of Radiology, Sydney, 2009
ARPANSA. RPS 14.2 Safety Guide for Radiation Protection in Nuclear Medicine. Australian
Radiation Protection & Nuclear Safety Agency, Yallambie, 2008; Contract No.: 2.
Release of patients after therapy with unsealed radionuclides. Ann ICRP 2004; 34:v–vi, 1–
79.
Vock P (ed). X-Ray Imaging & Pregnancy: Justification and Optimisation of Exposure.
European Society of Radiology, Vienna, 2010.
Health Protection Agency (HPA), “Protection of pregnant patients during diagnostic medical
exposures to ionising radiation: advice from the health protection agency,” Documents of
the Health Protection Agency: Radiation, Chemical and Environmental Hazards RCE 9, The
Royal College of Radiologists and the College of Radiographers, 2009.

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