Libro 1

University of Florida ........................................
Veterinary Medical Center
FORMULARY
University of Florida
2010
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University of Florida ........................................ Veterinary Medical Center
DISCLAIMER
This formulary is intended for use by the students, faculty,

and staff of the University of Florida, College of Veterinary
Medicine, and Veterinary Medical Center.
The Veterinary Medical Center makes no warranty with

respect to, or assumes no responsibility for, any results
which may be obtained from any information provided here.
All infonnation and doses provided were compiled with
faculty and resident input, as well as numerous reference
sources. The Veterinary Medical Center shall not be liable
for any damage resulting from reliance on any information
provided herein, or by reason of any misstatement or error
contained within this work.
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PREFACE
The formulary is a tool designed to provide basic

information for products stocked in our pharmacy. Many
products are included with the notation "special order." This
means we can obtain these products on an as needed basis;
due to cost factors or limited use of the product they are not
routinely stocked.
The dosages included are meant to serve as a guide; do not

use these dosages blindly. The dosages and infonnation
included come from a variety of sources including common
use in this hospital, manufacturer package inserts, other
formularies, textbooks, and past veterinary experience with
the product. Some of the dosages have not been updated in
many years.
We can only provide one copy to each student at the

beginning of clinic rotations in junior year.
The formulary has been proofread many times; however

errors and typos may persist. Please Jet us know of any
errors you identify. Forward all comments to the Manager
of Pharmacy Services.
Sandy Still, Pharm.D., FSVHP

Manager of Pharmacy Services
University of Florida
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University of Florida "',""'''''''''''''''''' '"'''''''''' Veterinary Medical Center
PHARMACY TALK - terms commonly used
SDV single dose vial; usually has no preservativcs - discard contents

24 hours after entering vial.
MDV - multi-dose vial; has preservatives; may be used for multiple

withdraws not to exceed expiration date on vial (some use shorter shelf
life - 30 days to 12 months),
DOSETTE vial- a small vial designed to provide one standard human

dose; mayor may not have preservatives,
CARPUJECT - a long cylindrical vial with needle attachment designcd

for administration usually as one dose via the carpuject injection device,
AMPule - a sealed glass vial that must be broken at the neck to

withdraw drug; solution should be filtered to prevent administration of
glass particles,
Capsule -- a football shaped oral dosage form, usually containing drug in

non-liquid form, Most capsules may be pulled open to release contents,
Tablet - a solid dosage fonTI, manufactured by compressing powders

into a tablet mold; can be round, diamond, triangular, pentagonal, square,
football shaped.
Caplet - a capsule-shaped tablet.
Pill - an "old fashioned" solid dosage form prepared by rolling

components on a pill tile into a round ball shape,
Diluent -liquid Llsed to dissolve the aclive, dry drug (aka reconstitute)
into a tormulation for injection or oral administration; drugs that must be
prepared by reconstitution will have a shortened shelf life and may need
to be refrigerated to maintain potency,
Bacteriostatic Diluent has preservatives and may provide the

reconstituted drug a longer shelf life with protection from bacterial
growth. Some drugs may not be physically compatihle with the diluent's
bacteriostatic agent and therefore cannot be used to reconstitute such a
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drug - check the label! Likewise, benzyl alcohol is a commonly used

bacteriostatic agent BUT is not advisable to be used for all patients.
Preservative free diluent provides no protection to the reconstituted

drug product against microbial growth.
Strength - the amount of drug per unit, i.e. mg/ml, mg/g, units/ml,
IU/ml, mEq/ml. Strength for some drugs is measured in units - beware -
all units are not 'International Units' or I.D.. There is usually a
conversion factor to change units to milligrams - which varies with the
drug!
Dose or Dosage - the amount of drug to be administered to the patient,

i.e. mg/kg, mg/lb, mg/m2, in some cases - mg per cat, rat, dog, horse.
Misbranding - labeling a drug by a brand name is okay ONLYifyolJ

are dispensing that brand name, otherwise you are misbranding, which is
illegal. All diazepam in NOT ValiumR !
Abbreviations Used in Prescription Writing - DO NOT create your

own. "Creative" abbreviations lead to medication errors.
gtt - drop
Sig - take thou
PO - per os - by mouth - orally
PR - per rectum - rectally
IV - by intravenous route
SQ - by subcutaneous route
1M - by intramuscular route
IC - by intra-cardiac route
QOD, EOD - once every other day, once every 48 hours.
QD - once a day, once every 24 hours
Ql2H - twice a day, once every 12 hours
Q6H - 4 times a day, once every 6 hours
Q4H - 6 times a day, once every 4 hours
Q24H=QD
SID - do not use in prescription writing
CRI - constant rate infusion (vs a bolus administration) may be
expressed as mg/kg/min, mcg/kg/min, mglkglhr, mg/hr, etc
Ears: AU - eachlboth ear(s); AD - right ear; AS -left ear
Eyes: OU - eachlboth eye(s); OD - right eye; OS -left eye
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TABLE OF CONTENTS
Disclainlcr ............................................................................. 4
Preface ................................................................................... 5
Pharn1acy Talk ...................................................................... 6
Abbreviations Use in Prescription Writing ........................... 7
Fonnulary (Acepromazine through Zinc Oxide) .................. 9
Appendix ........................................................................... 212
Conversion Table Body Weight to Meters Square ........... 213
Conversion Table for Metric Measurements ..................... 215
Table of Small and Large Volume Fluids ......................... 216
Table of Pharmacy Biologicals ......................................... 217
Cortrosyn Protocol. ............................................. 222
Expiration Dating ............................................... 223
Vaccine Guidelines: VMC Outpatient Medicine .............. 218
Olnnicell Notes ................................................................. 224
Heartworm Prevention Product Lis1.. ................................ 228
Shampoos, Rinses and Sprays ........................................... 230
Ophthalmic Product List ................................................... 230
Otic Product List ............................................................... 232
Flea Control Product LisL ................................................ 232
Fentanyl Patches ................................................................ 234
Soaker Catheter Notes ....................................................... 235
Diets and Iron Supplementation ........................................ 238
Energy Requirements ........................................................ 239
TPN Calculation Sheets for Dog, Cat ............................... 241
TPN Completed Prescription Examples ............................ 243
Index .................................................................................. 246
Notes ................................................................................. 270
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Acepromazine maleate PROMACE
USE: Phenothiazine tranquilizer
DOSE: Dog, Cat: 0.01 to 0.02 mg/kg IV, 1M, SQ; 0.55 to 2.2
mg/kg PO. Give IV doscs SLOWLY. Allow 15
minutes to effect. Allow 30 to 60 minutes to effect
when given orally.
Horse: 0.1 mg/kg IV, 1M, SQ for heavy sedation 0.04 to

0.06 mg/kg IV prior to general ancsthesia
FORMULATION: 10 mg (pink) and 25 mg (yellow) tablets; 10

mg/ml solution (yellow) fiJr injection; 1 mg/ml
solution for injection prepared in pharmacy
NOTE: 1. Phenothiazines can precipitate seizures in epileptic animals,

may potentiate the toxicity of organophosphates.
2. Hypotension can occur after rapid IV injection causing
cardiovascular collapse.
Acetazolamide
USE: A non-bacteriostatic sulfonamide that inhibits carbonic

anhydrase; acts as a potassium wasting diuretic useful in the
prevention ofhyperkalemic periodic paralysis (HYPP) in
Quarter Horses.
DOSE: Horse: 2 to 5 mg/kg PO BID to QLD.
FORMULA TION: 250 mg tablet
Acetic Acid 2%, Boric Acid 2% with surfactants MALACETIC Otic

Flush, MALACETIC Wet WipeslDry Bath
USE: An ear/skin cleanser.
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University of Florida ,. ...................................... Veterinary Medical Center
FORMULATION: Otic flush, apple scent - 4 and 16 oz bottles; wipcs

are 5" x T' 100 per jar
Acetylcvsteine MUCOMYST, generics
USE: Mucolytic; antidote to acetaminophen toxicity
DOSE: Ophthalmic: 20% solution diluted to 10% with artificial tears;

also, an ingredient in KCS solution.
Acetaminophcn toxicity: Dog, Cat: 140 mg/kg (ofa 5%
solution) IV loading dose, repeated q4h at 70 mg/kg (of 5%
solution) for 3 to 5 treatments.
Meconium impaction in foals: 8 g acetylcysteine, 2 oz sodium
bicarbonate, 20 cc water, given by retention enema. May repeat
in 2 to 4 hours.
FORMULATION: 20% solution, NOT FOR INJECTION in 10 ml

and 30 ml vials. This product is not listed for IV
injection, but clinicians dilute this product to a 5%
solution in 0.9% saline and administer it IV for life
threatening cases of acetaminophen toxicity. Filter
upon admixture for IV administration.
NOTE: Per manufacturer instructions - stable for 96 hours after opening

if stored in refrigerator
ACTH (Cosyntropin) CORTROSYN
USE: Diagnostic test for adrenocortical insufficiency, pituitary

dependent Cushing's disease.
DOSE: Dog, Cat: Body weight> 10 lb - give 0.25 mg I V or

Body weight < 10 Ib - give 0.125 mg IV or 1M
FORMULA nON: 0.25 mg per vial (single dose); dilute with 1 ml

0.9% saline for injection, discard any remaining
solution
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NOTE: 1. HUMAN PRODUCT

2. 0.25 mg approximately equal to 25 units
3. Post injection cortisol samples taken 45 to 60 minutes (dogs)
and 30 to 45 minutes (cats).
4. refer to VMC Policy in Appendix p221
Acyclovir
USE: An antiviral agent.
FORMULA TION: 800 mg tablet

2. Check for product availability
Adhesive STOMAHESIVE Paste
USE: Adhesive used to seal dressings for wound management with

vacuum assisted closure.
FORMULATION: 2 ounce tube
Albumin (l-luman)
USE: A natural colloid used clinically as a volume expander
DOSE: For IV administration only in dogs.
FORl'vlULATlON: 25% solution in ]00 ml bottle (contains 96'%

albumin, no clotting factors)· Special Order
Albumin (Canine)
USE: Indicated for treatment of hypovolemic shock or

hypoalbuminemia.
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DOSE: Hypovolemic shock: Dilute to 16% and administer IV at a fate

of I ml/minute. Total recommended dose is 2.5-5mllkg.
Hypoalbuminemia: Dilute to 1G% and give a total of 5-6ml/kg.

Maximum daily recommended dose is 2gm/kg . Administer as
an isotonic solution (5%) in normovolemic patients.
FORMULA nON: Canine albumin 5gm lyophilized powder in vial

(contains 98'% canine albumin)
Notes fiJT reconstitution:

I. Reconstitute with Normosol, 0.9% saline, or 5% dcxtrose (see
table below).
• DO NOT USE STERILE WATER to reconstitute.
2. At1er addition of diluent, gently swirl product until all powder is
rehydratcd.
3. Use reconstituted product within 24 hours.
Concentration Amount of Diluent

1--. 16% 30ml
1--
10% 49ml I
5% lOOml ,
Albuterol
USE: Bronchodilator (beta-adrenergic) for symptomatic relief of

reversible bronchospasm associated with bronchial asthma,
bronchitis
DOSE: Dog, Cat: O.J mg/kg PO q 12h

Horse: I actuation per 100 kg BID
FORMULA nON:
0.4 mg/ml symp;
for inhalation, as an aerosol in a metered dose inhaler providing
200 inhalations per canister 120 mcg albuterol delivering from
mouthpiece 108 mcg (much more expensive due to new
propellant)
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Alprazolam XANAX, generic
USE: A benzodiazepine used as an anxiolytic agent; in hospitalized

patients with excessive barking, out-patients with storm phobia,
separation anxiety.
DOSE: Cat: 0.125 to 0.25 mg per cat PO q12 - 24h

Dog: 0.02 to 0.05 mg/kg PO q4 - 6h, give 30 to 60 minutes
prior to anxious event
FORMULATION: 0.25mg,0.5mg, 1.0mg football shaped tablet
NOTE: HUMAN, CIV controlled substance

In humans, peak: plasma concentrations occur in I to 2 hours
Alteplase Cathflo ACTIVASE
USE: A tissue plasminogen activator, or tpa, (HUMAN product) for

treatment of acute thrombus formation of various causes.
DOSE: Dog: OAmg/kg IV hourly PRN

Cat: 0.25 to 1 mg/kg/hr IV as CRI (total dose 1 to 10mg)
FORMULATION: 2 mg (refrigerated)
PREPARATION: Mix just prior to administration - solution contains

no preservatives. Prepare solution using 2.2 ml of Sterile Water for
Injection - DO NOT use Bacteriostatic Water fot Injection. Inject into
vial, directing stream onto powder. Allow to sit and let large bubbles
dissipate. DO NOT SHAKE - Gently swirl vial to dissolve all contents,
should be within 3 minutes. Solution should be used within 8 hours.
Altrenogest 0.22% REGU-MATE
USE: To suppress estrus in mares.
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DOSE: ~on-pregnant mare: 0.044 mg/kg PO daily fiJf 8 to 12

consecutive days; follow with
PGF2alpha for estrus.
Horse: 0.044 mg/kg QD to control aggressive behavior.
Swine: Estrus synchronization in cyclic sows, 15 to 20
mg/day for 14 to ]8 days.
FORMULATION: 2.2 mg/ml ORAL solution; LIGHT SENSITIVE
NOTE: USE CAUTION WHEN HANDLING. Do not allow contact

with human skin. Pregnant women and women of childbearing
age should not administer this product or should use extreme
caution. Wear rubber gloves. Others who should NOT handle
this product include: anyone with thrombophlebitis or
thromboembolic disorders; anyone with cerebral-vascular or
coronary-artery disease; anyone with estrogen dependent
neoplasia, or benign or malignant tumors which developed
while Oil oral contraceptives or estrogen-containing products, or
carcinoma of the breast; women with undiagnosed vaginal
bleeding; anyone with liver dysfunction or disease.
Aluminum Hydroxide Gel
USE: An oral antacid used in the treatment of esophagitis, gastric

hyperacidity, gastritis, byperphosphatemia
DOSE: 50 mg/kg PO TID to QID
FORMULATION: Available as oral suspension, each 5 ml contains

320 mg of aluminum hydroxide gel in a mint
flavored suspension.
NOTE: HUMAN PRODUCT - available OTC at retail stores
Amikacin AMIGLYDE-V
USE: Aminoglyeoside antibiotic
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DOSE: Dog: 5 mg/kg q8h 1M, IV

Horse: 10 mg/kg q24h IMIIV
Neonatal Foals: 25 mg/kg IMlIV q24h. Measurement of
peak and trough levels recommended with
chronic administration.
Psittacines: Pseudomonas resistant to gentamicin: 13 to 20
mg/kg IMBlD
AUigator: 2.25 mg/kg q96h
Tortoise: 5 mg/kg q48h
Snakes: 5 mg/kg for first dose, then q72h 2.5 mg/kg
FORMULATION: 50 mg/ml (unavailable), 250mg/ml
NOTE: Contraindicated in impaired renal function. Aminoglycosides

are nephrotoxic and ototoxic; consider the risk of neuromuscular
blocking and respiratory paralysis when given with or after
anesthetics, neuromuscular blocking agents, and
succinylcholine.
Aminocaproic Acid
USE: Fibrinolysis inhibitor (urokinase inhibitor). Inhibits plasminogen

activator substances; used to control excess clot dissolution
caused by increased plasmin activity. Used to arrest
postoperative urinary bleeding.
Also used for supportive treatment of degenerative myelopathy

in German Shepherd dogs. Thought to act as an anti-
inflammatory drug by inhibiting extracellular enzyme activity.
DOSE: Urinary bleeding: Dog: 80 mg/kg IV over 1 hour then 20

mg/kg/hr IV hourly. 80 mg/kg PO initially then 20 mg/kg PO
hourly for 8 hours.
Degenerative myelopathy in German Shepherds: 15 mg/kg (or
500 mg/dog) PO q8h
Horse: hemorrhage: 20 to 80 mg/kg IV diluted 1 part

aminocaproic acid to 9 parts saline; administered over 30 to 60
minutes
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FORMULATION: 250 mg/ml, solution for injection in 20 ml vial.
NOTE: Rapid IV injection may cause hypotension, bradycardia and

arrhythmias
Aminophylline
USE: Bronchodilator with mild diuretic and positive inotropic

(cardiac) effects.
DOSE: Dog: 4 to 8 mg/kg IV, 10 mg/kg PO q6 to 8h

Cat: 5 mg/kg PO q8 to 12h
Horse: 4 to 7 mg/kg PO, 1M TID
FORMULATION: 500 mg/20 ml vial for injection - LIGHT SENSITIVE
NOTE: 1. For IV use, dilute in 10 to 20 ml of saline or D5W and

administer SLOWLY!
2. The oral dose should be decreased by 30 to 50% with hepatic
congestion or cirrhosis.
COMMON SIDE EFFECTS: Restlessness, nausea, vomiting,

tachycardia.
RARE SIDE EFFECTS: Arrhythmias, tremors, seizures, tachypnea.
DRUG INTERACTIONS: Cimetidine, erythromycin, and beta-blockers

may decrease hepatic metabolism.
Phenobarbital and diphenylhydantoin may
increase the clearance of aminophylline.
Amiodarone HCr injection
USE: An antiarrhythmic which prolongs the action potential duration

and refractory period in myocardial cells, also acts as a non-
competitive inhibitor of alpha- and beta-adrenergic receptors.
Indicated only for life-threatening, recurrent, ventricular
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arrhythmias that are not responsive to other anti-anythmic

agents. Also used to convert atrial fibrillation; treatment of
ventricular fibrillation refractory to shock.
DOSE: Dog: For acute conversion of atrial fibrillation: 0.33-0.5

mg/kg/min short term IV infusion; 10-20 mg/kg q24h
PO for 7-10 days (loading dose); 3-15 mg/kg q24h
(maintenance dose).
Bolus dose for VTNF in CPR: 5mg/kg IV over 10
minutes, followed by 2.5mg/kg over 3-5 minutes if
necessary.
Horse: IV: 5mg/kg/hour for 1 hour, followed by

0.83mg/kg/hour for up to 48 hours.
FORMULATION: 50 mg/ml in 18 ml vial
NOTE: For IV usc, add 5ml of amiodarone (50 mg/ml) to 45 ml of 5%

dextrose in water to make a solution of 5 mg/ml of amiodarone.
Check for dmg interactions.
SIDE EFFECTS:
1. CAUTION: Short tel111 hypotension, hyperemia, superficial
phlebitis, pmritus can be seen during IV USE due to the solvents
(polysorbate 80, benzyl alcohol). May premedicate with
corticosteroid and/or diphenhydramine to prevent these reactions.
2. Oral use can be proarrhythmic and may result in reversible
hepatopathy, blood dyscrasia, and thyroid abnormalities.
Amitriptyline HCI
USE: A tricyclic antideprcssant with anticholinergic, antihistaminic

and local anesthetic properties; used for prevention of idiopathic
(interstitial) cystitis in cats; and narcolepsy and separation
anxiety in dogs.
DOSE: Cat: 2.5 to 5 mg PO qI2 to 24h

Dog: 1 to 2 mg/kg PO qI2 to 24h
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FORMULATION: 10 mg tablet; check for availability.
CONTRA INDICA TIONS:

Should not be used in animals with cardiac disease, urinary retention,
seizure activity, angle-closure glaucoma or increased intraocular
pressure. Use with caution in animals with diabetes mellitus,
hyperthyroid disease, hepatic or renal disease. Check for drug
interactions.
Amlodipinc NORVASC
USE: A calcium channel blockers used in the treatment of systemic

hypertension in dogs and cats.
DOSE: Cat: Less than 5 kg - 0.625 mg PO q24h; greater than 5 kg-

1.25 mg PO q24h
Dog: 0.06 to 0.1 mg per pound PO g24h
FORlvHJLA nON: 2.5 mg tablet; reformulated to 0.625 mg capsule -

check with phannacy for availability
NOTE: HUMAN PRODUCT
Ammonium Chloride Powder UROEZE
USE: Urinary acidificr. Used to prevent struvite crystalluria and

adjunct treatment to prevent urinary tract infection. Also used to
assess liver function
DOSE: Urinary acidification:

Dog: 50 to 100 mg/kg PO q 12h mixed with food
Cat: 80 to 120 mg/kg PO q12h mixed with food
Goat, l>ot-bcllicd Pig: 50 to 200 mg/kg, adjust dosage to
achieve desired pH
Ammonia tolerance test: Dog, Cat: 0.5 mIlkg of 20% solution

PO up to 15 ml maximum.
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FORMULATION: As powder in a 4 ozjar, providing 400 mg

ammonium chloride per y'level teaspoonful
NOTE: Ammonium chloride fed to kittens at therapeutic levels can be

fatal. Some adult cats develop weakness, metabolic acidosis and
hypokalemia. Dogs tend to have diarrhea at these doses.
Amoxicillin AMOXI-DROP, AMOXI-TAB
USE: Semi-synthetic penicillin antibiotic
DOSE: Dog, Cat: 11 to 22 mg/kg PO q8 to 12h. There is wide

variation of dosages used.
FORMULATION: 100 mg, 400 mg film-coated tablets; 50 mg/ml oral

suspension, in 15 ml and 30 ml bottles with
calibrated dropper
NOTE: Oral suspension retains potency for 14 days after mixing-

refrigeration recommended.
Amoxicillin with Clavulanic Acid CLA VAMOX
USE: Antibiotic combination containing amoxicillin (a penicillin

antibiotic), and clavulanate potassium (a B-lactamase inhibitor)
DOSE: Dog: 14 mg/kg PO BID

For staphylococcal skin infection: 22 mg/kg PO BID
Cat: 62.5 mg per cat PO BID
FORMULATION: 62.5 mg, 125 mg, 250 mg, 375 mg tablet in foil
sealed strips; 62.5 mg/ml, in 15 ml bottle with
calibrated dropper
NOTE: 1. Tablets should not be cut - MOISTURE SENSITIVE.
- 19 -
2. Suspension retains potency for 10 days after mixing - must be

refrigerated. If left at room temperature, stable for only 48
hours per manufacturer.
Amphotericin B
USE: Systemic antifungal antibiotic
DOSE: Dog, Cat: 0.25 mg to 1 mg/kg 2 to 3 times a week on alternate

via SLOW IV or IP injection with D5W
Horse: 0.3 mg/kg day 1, 0.45 mg/kg day 2,0.6 mg/kg day
3 then 0.6 mg/kg every 2nd day for 28 days. Dilute in lL of
D5W and infuse over 1 hour.
Raptors: 1.5 mg/kg IV TID for 3 days; nebulize: 1 mg/ml

sterile saline, at 15 mg BID; intra-tracheal: 1 mg/kg, dilute to 2
ml with sterile saline
Psittacincs: nebulize: 1 mgiml sterile saline, at 15 mg BID;

intratracheal: 1 mg/kg, dilutc to 2 ml with sterile saline
FORMULATION: 50 mg/vial to be reconstituted.
ADVERSE REACTIONS: Monitor BUN for signs of renal toxicity.
POTENTIAL SIDE EFFECTS: Cardiac arrhythmias, phlebitis, anemia,

anorcxia, fevcr, nausea, and
hypokalemia
NOTE: I. HUMAN PRODUCT.

2. Light sensitive.
3. Read insert - very specific directions for reconstitution..
4. In Rill2tQ]3, used in conjunction with 5-flucytosine.
Ampicillin
USE: Broad-spectrum bactericidal, semi-synthetic penicillin antibiotic
- 20 -
DOSE: Dog, Cat: 5 to 25 mg/kg PO q8h; 5 to 25 mg/kg 1M, IV, or

SQ.
Horse, neonatal foal and adult: 20 mg/kg IV q6h
Bovine: 4 to 11 mg/kg 1M QD. Do not treat for more than 7

days; 48h milk withdrawal; 6 day slaughter withdrawal.
Tortoise: 50 mg/kg q12h
Amazons: Pasteurella, Streptococcus: 150 to 200 mg/kg PO

TID, QID. Systemic disease: 100 mg/kg 1M q4h
Pigeons: 25 mg/kg 1M BID
FORMULATION: 250 mg, 500 mg capsule
For INJECTION: Ampicillin sodium is available in 1 gram vials;

Ampicillin trihydrate suspension (POL YFLEX)
*IM only* in 10 gram, 25 gram vials
NOTE:
1. Stability: the stability of sodium ampicillin is concentration
dependent. As the concentration increases, the stability decreases.
Sodium chloride is a suitable diluent for preparing sodium
ampicillin for IV use ... dextrose greatly decreases the stability.
Temperature and pH also affect the stability.
2. Sodium ampicillin mixed with sterile water to 100 mg/ml is stable
for up to 1 hour at room temperature. Diluting further (up to 20
mg/ml) and refrigerating increases the shelf life to 72 hours.
3. POLY FLEX (ampicillin trihydrate) has a long shelf life after
reconstitution; may only be administered 1M.
Ampicillin sodium with sulbactam sodium UNASYN
USE: An ampicillin with a spectrum extended by sulbactam to include

beta-Iactamase producing strains.
DOSE: Dog, Cat: 15 mg/kg IV TID. Give at 30 mg/ml over 20 to 30

minutes slow infusion.
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FORMULA nON: 1.5 gram vials (1 gram ampicillin and 0.5 g

sulbactam, as sodium salts)
NOTE:
1. For Reconstitution, add 3.2 ml sterile water or 0.9% saline to the
1.5gram vial, yields 375 mg/ml.
2. Immediately further dilute solution with 46ml of diluent
(saline), yields 30 mg/ml solution.
3. Stable in 4°C retrigerator for up to 72 hours.
4. Solution can be made to 45 mg/ml, stable in 4°C refrigerator for
48 hours.
Antivenin Coral Snake
USE: Antivenin for North American Eastern Coral Snake (Micrurus

fulvius)
DOSE: 1 to ] 0 TV, given as soon as possible after envenomation
FORMULATION: HUMAN PRODUCT - NO LONGER

AVAILABLE FOR VETERINARY USE
Antivenin (Crotalidae) Polyvalent ImmuneFAB (ovine) - CROFAB
USE: A lyophilized preparation of ovine Fab immunoglobulin

fragments, providing binding and neutralizing for venom toxins of
the Western and Eastern Diamondback, and Mojave rattlesnakes,
and the Cottonmouth or Water Moccasin.
DOSE: Administer at 1 vial CroFab = 5 vials Ft Dodgt~ Crotalidae

Polyvalent Antivenin
In HUMANS - CroFab is repeated every 6 to 8 hours during the first 24

hour period, because the venom tends to leach out of muscle and fe-exert
its fibrinogenolytic effect. This may also occur in dogs. One vial may be
adequate. Altematively, the dose may be divided and Y:, given initially
and the second 1/2 given 6 hours later.
- 22 -
In HUMANS - the initial dose should be given at rate of25-50 mllhr (of
diluted product) for the first 10 minutes, then if no allergic reaction-
increase rate to 250mllhr until done.
NOTE:
1. HUMAN
2. Refrigerated
3. Cost approx $1300 per vial
4. CroFab is still anaphylactogenic, but to a lesser extent than Ft
Dodge Polyvalent Antivenin.
5. To Reconstitute: mix with 10ml of sterile water for Inj, by
continuous gentle swirling. Further dilute contents in 250ml if
Saline 0.9% and mix by gentle swirling. Reconstituted and diluted
product should be used within 6 hours.
Antivenin (Crotalidae) Polyvalent by Fort Dodge
USE: Antivenin for Eastern diamondback rattlesnake, copperhead,

and cotton mouth moccasins
DOSE: 1 to 10 vials, IV, depending on severity of symptoms, time-lapse

after envenomation, size of animal, and snake.
5 to 10 vials usually needed for Eastern diamondback

rattlesnake envenomation. Antivenin is best given within 4
hours of envenomation.
FORMULATION: 10 ml vial with diluent, Equine origin
NOTE:
1. Glucocorticoids will inhibit the effect of antivenin; therefore do
not use in the setting of antivenin administration.
2. Reports of anaphylactic shock in dogs who had been previously
treated with antivenin (from a prior exposure).
3. Cats may be predisposed to anaphylaxis.
4. To reconstitute: shoot stream of diluent directly onto cake. DO
NOT shake - causes foaming. May take up to 30 minutes to
dissolve.
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Apomorphine
USE: Centrally acting emetic used in dogs and cats
DOSE: Dog: 0.03 to 0.04 mg/kg IV; 0.04 - 0.08 mg/kg 1M or SC; 0.25
mg/kg per conjunctival sac
Cat: 0.04 mg/kg IV; 0.08 mg/kg 1M or SC
FORMULATION: Packaged as a kit with powder, diluent and

instructions to prepare for administration
Artificial Tears Solution
USE: Ophthalmic lubricant
DOSE: Instill in eye(s) PRN
FORMULA TTON: 15ml, 30 ml, with dropper tip; polyvinyl alcohol

1% and polyethylene glycol 400 1%
Artificial Tears Solution
FORMULATION: 25 ml, with dropper tip; hypromellose 0.3%
Artificial Tears Gel GENTEAL GEL
- 24-
University of Florida ............................ '" .......... Veterinary Medical Center
FORl\1ULATION: 10 ml; hypromellose 0.3%
Artificial Tears Ointment
USE: Ointment base, lubricant, moisturizer
DOSE: To the eye as needed
FORMULA nON: 3.5 gram tube: 83% Petrolatum White, 15%

Mineral Oil, Lanolin Oil
Ascorbic Acid VITA'\Hl'< C
USE: Nutritional supplement; also used for antioxidant properties in

the treatment of reperfusion injury to the optie nerve in
glaucoma patients.
DOSE: Dog: Ophtho: 500 mg PO QD

Horse: 30 mg/kg BID; IV J1uids
FORMULATION: 250 mglml for injection
L-Asparaginase ELSP AR
USE: Antineoplastic agent, commonly use as an induction drug, or as

a rescue drug for relapsing lymphoma
DOSE: Dog, Cat: 400 IU/kg 1M or SQ; 20,000 1U/m2 in dog
CONTRAINDICA TIONS: Pancreatitis and hypersensitivity to

asparagmase.
TOXICITIES: I. Anaphylaxis has been reported following injection.

2. Rare, fatal hemolThagic pancreatitis has been
reported following injection.
3. Contraindicated in patients with history of
pancreatitis.
- 25 -
COMMENTS: Does not suppress the bone marrow response.
FORMULA nON: 10,000 IU/vial
NOTE: 1. HUMAN PRODUCT.

2. Must be refrigerated.
~spirill Acetylsalicylic Acid; ASA
USE: Anti-inflammatOlY, antipyretic, analgesic, prevent or reduce

thromboembolism.
DOSE: Dog: Analgesic: 10 mg/kg PO ql2h: Anti-inflammatory: 25

mg/kg PO ql2h; AntiJ;ili!~l91J!ggLegation: 5 1l1g/kg PO
q2411 to 48h
Cat: Analgesic: 10 1l1glkg PO q52h; Anti-inflammatory: 40
mg/kg PO q72h; AntiplateJet aggregation: 5-20 1l1g/cat
PO q72h
FOIZl\1ULATlON: 325 mg buffered tablet, 81 mg tablet (children's

chewable), 240 grain bolus (15,600 mg)
NOTE:
1. Contraindicated in von Willcbrand's disease.
2. Can cause upper gastrointestinal ulceration and bleeding.
Discontinue if melena occurs.
------------------------_._------
AtenoloI
USE: A beta adrenergic blocking agent with specificity for [\1 receptor
(except at higher doses). Indicated for usc in hypertrophic
cardiomyopathy, ventricular arrhythmias, atrial fibrillation,
hyperthyroid heart disease, hypertension.
DOSE: Dog: 0.25 - 1 mg/kg PO q12 - 24h

Cat: 6.25 - 12.5 mg per cat q 12h (appro x 3 mg/kg)
- 26 -
FORMULATION: 25 mg tablet; compounded suspension upon request.
Atipamezole ANTISEDAN
USE: A specific alpha-2 antagonist with greater selectivity and

receptor affinity than yohimbine; used as a reversal agent for
medetomidine, dexmedetomidine.
DOSE: Dog: use 3 to 5 times the dose (not the volume) of

dexmedetomidine/medetomidine administered; given IM, at
equal volume as dexmedetomidine/medetomidine.
FORMULATION: 5 mg/ml; 10 ml vial
NOTE: This product may be dosed at the same volume as the volume of
dexmedetomidine/medetomidine administered.
SIDE EFFECTS: 1. Occasional vomiting may occur.

2. Rarely, a brief state of excitement or
apprehensiveness may occur.
3. Hypersalivation, diarrhea and tremors.
Atracurium Besylate TRACRIUM
USE: Short-acting, non-depolarizing muscle relaxant used to produce

muscle relaxation in anesthetized patients undergoing short
procedures
DOSE: Dogs, Cats, Horses: 0.4 to 0.5 mg/kg; maintenance dose is

0.1 mg/kg.
CAUTION: Use only in conjunction with. a general anesthetic.
FORMULATION: 10 mg/ml injection, 10 ml, HUMAN PRODUCT.
Atropine Sulfate
- 27-
USE: Anticholinergic agent
DOSE: Dog, Cat: Acute organophosphate intoxication: Dose at 0.22

mg/kg, with one-half of dose to be given IV and
remainder to be 1M; repeat q15 to 30 minutes until
atropinization occurs; then give q6h for an
additional 48 hours
Horse: 0.02 to O.l mg/kg IV, 1M, SQ
Bovine, Swine, Sheep: As pre-anesthetic: 2 mg per 100 Ib ill

reduce hypermotility: 10 mg/lOO lb.
Antidote for organophosphate toxicity: Bovine: 0.1 to Img/kg
IV, 1M, SQ
FORMULATION: 0.54 mg/ml injection; 15 mg/ml injection for large

animal
NOTE: Availability problems with small animal product.
Atropine 1% Sulfate Ophthalmic
USE: Cycloplegic and mydriasis
DOSE: 1 to 2 drops, or a small strip, into eye as needed
FORMULATION: Sterile ophthalmic ointment in 3.5 gram tube;

sterile ophthalmic solution in 15 ml dropper tip
bottle.
CONTRAINDICATION: Glaucoma
Azathioprine IMURAN, generic
USE: Immunosuppressive agent
DOSE: Dog: 2.2 mg/kg PO q 1 to 2d

Cat: 0.3 mg/kg PO q 1 to 2d
- 28 -
CONTRAINDICATIONS: Hypersensitivity to azathioprine, neutropenia

<2,000/f.t!.
DRUG INTERACTIONS: Allopurinol decreases hepatic metabolism of

azathioprine by inhibition of xanthene
oxidase; reduction of azathioprine dose by 66
to 75% is indicated when the drugs are used
concurrently.
TOXICITIES: Leukopenia, thrombocytopenia, macrocytic

anemia and bone marrow suppression.
Hematologic toxicities are dose-related.
FORMULATION: 50 mg scored tablet. Must be reformulated for very

small animals.
NOTE: HUMAN PRODUCT.
Azithromycin ZITHROMAX
USE: An azalide antibiotic (a subclass of macrolide antibiotics). Used

in treatment of resistant R. equi infection
DOSE: Foal: 10 mglkg PO once daily; OR 10 mg/kg PO once daily

for 4 days then every other day]
Cat: 7 to 10 mglkg PO q24h x 14 days, then 5mg/kg q24h x

7 days, then 5 mg/kg q48h x 14 days.
Rodent: 20 mg/kg PO q24h (periodontal abscesses)
Rabbit: 30 mg/kg PO q24h (periodontal abscesses)
FORMULATION: 250 mg tablet; cherry flavored oral suspension

20mg/ml, 15ml (when mixed) with a 10 day shelf
life after mixing
- 29-
Bacitracin, Neomycin, Polymyxin B TRIOPTICP, Triple Antibiotic

Ophth Oint Plain
USE: Triple antibiotic ophthalmic ointment
DOSE: Apply in affected eye TTD to QID
FORMULATION: Sterile ophthalmic ointment in 3.5 gram tube
Bacitracin, Neomycin, Polymyxin B, Hydrocortisone 1% TRIOPTIC

S, Triple Antibiotic Ophth Oint with Steroid
DOSE: Apply a small amount into eye TlD to QlD
FORMULATION: Sterile ophthalmic ointment in 3.5 gram tube
CONTRAINDICA TION: Comeal ulceration
Benazepril HCl LOTENSIN
USE: An ACE inhibitor; used in the treatment of heart failure,

hypertension, chronic renal failure, and protein losing
nephropathies.
DOSE: Dogs: 0.25 - 0.5mg/kg PO once a day to

twice a day.For hypertension: 0.25 mg/kg PO twice a day.
Cats: EQl' heillU'<lillJ[~: 0.25 mg!kg PO once a day.
FORMULATION: 5 mg, IOmg tablets (other strengths manufactured)
NOTE: Remind clients not to abmptly discontinue medication; and to

report signs of weakness, anorexia, vomiting, dianhea to
veterinarian.
Benzocaine 14%, Butyl Aminobenzoate 2%, Tetracaine HCI2%

CETACA['fE SPRAY
- 30 -
University of Florida ................................... " ... Veterinary Medical Center
USE: Topical anesthetic for mucous membrane
FORMULA nON: As a spray; 56 g bottle with propellant. SPECIAL

ORDER
Benzoic, Malic, Salicylic Acid DERMA-CLENS
USE: To aid in wound debridement and healing
DOSE: Apply twice daily
FORMULATION. 14 ounce jar

------------------_._-_._-------------
Benzoyl Peroxide 2.5% MICROPEARLS BEXZOYL PLUS

SHAMPOO for DOGS & CATS
USE: A non-drying antimicrobial, keratolytic, antipruritic shampoo

for topical therapy of pyodenna, folliculitis and sebOlThea
complex
DOSE: Dog. Cat: Shake well, wet coat thoroughly, lather, let stand for
10 minutes, rinse well. Repeat if needed. May be used daily or
weekly.
FORMULATiON: 8 oz bottle
NOTE: May bleach colored fabric
Bellztropine mesylate COGENTIN
USE: A muscarinic receptor antagonist used in horses to relieve

priapism/paraphimosis orthe penis caused by the administration
of acepromazine or general anesthesia **This product has been
discontinued. Alternate treatment is lOmg of 1(Yo phenylephrine
into erect corpus cavemosum penis
- 31 -
DOSE: Horse: 8 mg/1 000 pounds IV or 1M
NOTE: HUMAN PRODUCT. Use caution in hot weather- may produce

anhidrosis (in humans)
Bethanechol Chloride URECHOLINE
USE: Cholinergic agent; used to stimulate bladder contraction in

atonic bladder
DOSE: Dog: 5 to 25 mg PO q8h

Cat: 2.5 to 5 mg PO q8h
Horse: 0.4 mg/kg TID to improve gastric emptying
Reptile: 2.5 mg/kg SQ
FORMULATION: 25 mg tablet - check for availability
NOTE:
1. Try lower dose first.
2. Give on an empty stomach.
3. Always try conservative dose first. High doses may cause
vomiting, diarrhea and colic. Only give when there is no
urethral outflow obstruction. May be given in combination with
alpah-adrenergic antagonists to simultaneously increase detrusor
muscle tone and reduce urethral resistance.
4. Toxicity shows with cholinergic signs. Atropine is antidote.
Bifidobacterium animalis AHC7 PROSTORA MAX
USE: A probiotic nutritional supplement for dogs of any age, to help re-
establish micro flora balance in acute enteritis, antiobiotic therapy,
food intolerance, stress due to travel, weaning, boarding, intestinal
disturbances due to long-term illness.
DOSE: Day 1: 2 chews in AM and 1 chew in PM; Day 2 thru 7: 1

chew in AM and 1 chew in PM
FORMULATION: 15 chewable supplements per package.
- 32-
NOTE: When using partial tablets, store remainder of tablet in sealed

ziplock bag in cool dry place and use remainder at next dosing
interval.
Bismuth Subsalicylate PEPTO-BISMOL
USE: Symptomatic control of diarrhea in dogs and cats
DOSE: Dog, Cat: 2.2 mllkg PO divided q4h. Do not use for more than 3
days.
Horse: I to 2 liters per 450 kg PO BID
FORMULATION: 262 mg swallow caplets (provides 99 mg

salicylate); and 262 mg per 15 ml oral suspension
(total salicylate = 130 mg per 15 ml).

2. Causes black, tarry stools
3. Cats dislike product
4. More acceptable when refrigerated
Bismuth Subsalicylate 1.75% GASTRO-COTE
USE: Symptomatic control of diarrhea
DOSE: Bovine: 4 to 8 oz PO q6h up to 32 oz q12h

Calves, Foals: 0.5 ml/k:g PO QID
Horses: 0.25 to 0.5 ml/kg PO QID
FO RMULA TlON: Order by the ounce
Bleomycin
USE: A rescue agent for canine and feline lymphoma. An antimicrobial

cytotoxic agent.
DOSE: Dogs, cats: 0.54 units/k:g SQ
- 33 -
FORMULATION: 15 units/5ml vial (3 units/mll
CONTRAINDICATlONS: Pre-existing non-tumor related pulmonary

disease or signs of pulmonary effects developing hom previous
treatment. Pulmonary toxicity may be fatal but is potentially reversible if
treatment is stopped. Do not exceed a maximum dose of 125-200mg/m 2
to avoid development of pulmonary toxicity. Use with caution and
reduce dose in patients eith renal impairment.
TOXICfTIES: Toxicity may be acute or delayed. Acute toxicity

includes fever, anorexia, vomiting, anaphylaxis. Delayed toxicity
includes dermatologic effects, stomatitis, pulmonary fibrosis.
Bupivacaine ReI 0.75%, Dextrose 8.25'% SENSORCAINE - MPF

SPINAIJ, generic
USE: Local anesthetic, long acting
FORMULA nON: 2 ml ampule
NOTE: Can be cardiotoxic in TV administration or with high doses
Bupivacainc 0.25%
USE: Local anesthetic, long acting; for usc in soaker catheter
FORMULA nON: 2.5 mg/ml; 50 1111 MDV
NOTE: For infiltration and nerve bloaek. Do NOT use for caudal
epidural or spinal anesthesia. Se APPENDIX for Soaker
Catheter Notes from Dr. Davis.
Buprenorphine
USE: Semisynthetic partial opiate agonist, used as an analgesic
- 34-
DOSE: Dog: 0.01 mg/kg - 0.02 mg/kg SQ q8h; alternative (per Plumb)
for analgesia: 0.005 mg/kg to 0.02mg/kg 1M, IV, SQ q6-12H
Cat: Kitten: 0.01 mg/kg SQ q8h. Adult: 0.02 mg/kg SQ q8h;

for buccal mucosa absorption - 0.01 to 0.02 mg/kg on tongue,
under tongue, on gums q8h; alternative (per Plumb) for
analgesia: 0.005 to 0.01 mg/kg 1M, IV, SQ q6-12H
Reptile: 0.03 mg/kg QD
FORMULATION: 0.3 mg/ml in I ml ampule
NOTE: HUMAN PRODUCT, Controlled substance - cm

Conflicting reports regarding withdrawal syndrome in humans
upon discontinuance of therapy
Butorphanol TORBUGESIC, TORBUGESIC - SA, TORBUTROL
USE: A synthetic opiate partial agonist
DOSE: Dog: antitussive: 0.05 to 0.1 mg/kg SQ q6 to 12h; 0.55 to

1.lmg/kg PO q6 to 12h
analgesic: 0.05 to 0.4 mg/kg IV, SQ q6 to 12h; O.22mg/kg PO
ql2h; OR give 17.8 mcg/kg loading dose, then give 23.7
mcg/kg/hr as CRi
Cat: analgesic: 0.4 to 0.8 mg/kg SQ q6h; 1 mg per cat PO q12h
Horse: 0.05 mg/kg to 0.1 mg/kg IV OR as constant rate

infusion: 15 mg/ 450 kg then 13.2 mcg/kg/hr
Avian: begin at 0.5 mg/kg up to 2.0 mg/kg for small parrots
FORMULATION: 2 mg/ml inj (Torbugesic SA) - Indefinite

backorder as of April 2010
10 mg/ml inj (Torbugesic);
1 mg tablet (Torbutrol)
- 35 -
University of Florida.. ..................... " ............... Veterinary Medical Ccnter
NOTE: Controlled substance - C-IV. May cause excitement when

administered alone to horses.
N-hutylscopolammomium bromide BUSCOPAN
USE: An anti-spasmodic, indicatcd for use in horses for spasmodic

(gas) colic. May also be used to assist in rectal examination to
decrease straining.
DOSE: Horse: O.3mg/kg IV bolus
FORMULA TlON: 20mg/ml solution for injection; order byml or

50ml MDV
Caffeine
USE: Respiratory stimulant, indicated for treatment of eNS -

associated hypoventilation.
DOSE: Neonatal foal: 10 mg/kg PO on day 1, then 2.5 rug/kg PO daily.
FORMULATION: 200 mg tablet- Special Order Only
Calcitonin-Salmon MIACALCIN
USE: Treatment of hypercalcemia. Preferred treatment for

cholecalciferol rodenticide intoxication.
DOSE: 4 MRC units/kg IV; 4 to 8 MRC units/kg SQ q 12 to 24h (human

dose).
FORMULATION: 2 ml vial containing 200 IU per m!
NOTE:
1. STORE IN REFRIGERATOR 2° to 8 0 (36 0 to 46° F).
2. HUMAN PRODUCT.
- 36-
3. Use of this drug usually preceded by parenteral saline,

furosemide and prednisone.
4. MRC = Medical Research Council (British).
5. 1 MRC unit = 4 mcg pure porcine calcitonin
6. Expensive.
Calcitriol Dihydroxycholecalciferol
USE: Used in the management of hypocalcemia, also used in the

treatment of renal secondary hyperparathyroidism in chronic
renal failure.
DOSE: Dog: hypocalcemia: 20 to 30 nanogram/kg/d PO, divided BID

for 2 to 3 days, then 5 to 15 nanogram/kg/d divided BID (from
Chew and Nagode 2000).
Dog: renal failure: 2.5 to 3.5 nanogram/kg/d PO, divided ql2h,

adjust based on serial iCa and PTH measurements, ending
between 0.75 to 5.0 nanogram/kg/d.
Alternative "pulse-dosing" regimen: use when PTH is > 10 times

normal or lack of appropriate response to daily dosing. Start
does is 20 nanogram/kg twice a week. Monitor calcium levels
closely. Eventually, these patients are switched to daily dosing.
Hypoparathyridism: Dog: 20 to 40 nanogram/kg/d - start slowly

and titrate to effect. Cat: 10 to 40 nanogram/kg/d - titrate to
effect.
Hyperparathyrodism secondary to renal failure: Dog: 20 to 40

nanogram/kg/d - start slowly and titrate to effect. Cat: 10 to 40
nanogram/kg/d - titrate to effect.
FORMULATION: 0.25mcg capsule
NOTE:
1. Also known as dihydroxyvitamin D3
- 37 -
Calcium Borogluconate 23% CAL-NATE 1069, generics
USE: A hypertonic solution, used to treat hypocalcemia
DOSE: Horse: To effect IV; 100 to 300 ml IV for synchronous

diaphragmatic flutter. May also be administered as 125
m! per 5 L TV fluids.
Bovine: 500 to 1000 ml 23% IV, 1M or SQ
Sheep: 25 to 50 m! 23% IV, 1M or SQ
Swine: 50 to lOO 1111 23% TV, 1M or SQ
Divide injection sitcs when giving 1M or SQ
FORMULATION: 23% solution, 500 ml bottle; provides calcium

21.4 mg/ml, and boric acid as a solubilizing agent.
Calcium Glubionate 1.8 g/5ml, Svrup
USE: A supplement for the prevention of calcium deficiency
FORl'v1ULATION: Oral solution contains 115 mg of calcium per 5 ml

(as calcium glubionate); order by the ml; provides
calciwn 23 mg/ml.
Calcium Gluconate
USE: Eclampsia, hypocalcemia, EM-dissociation during cardiac

arrest. cardio-protectant witb severe hyperkalemia
DOSE: Dog, Cat: Acute Hypocalcemia: 0.5 to 1.5 mllkg SLOWLY

IV over 5 to 10 minutes, then maintain on 5 ml/kg
rv over 24 hours or 2 ml/kg q6h IV infusion
Eclampsia: 1 mllV stat, followed by 0.5 ml q30
seconds. Discontinue when the tetany ceases or
when the animal vomits.
Psittacines: Treatment of hypocalcemia: 0.1 to 0.2 mg/g of
- 38 -
body weight 1M, IV as needed. In diet: 100 mg to

200 mg/kg/day
FORMULATION: 10% solution (0.45 mEq Ca++ per ml) in 10 ml

vial. Do not add to bicarbonate-containing
solutions.
NOTE:
1. ECG-monitoring during the infusion is advisable; discontinue if
bradycardia or vomiting occurs at the acute dose.
2. Wildlife: can cause muscle irritation when injected undiluted.
SIDE EFFECTS: Cardiac arrhythmias
Carhoplatin PARAPLATIN, generics
USE: Antineoplastic agent
DOSE: Dog: 300 mg/m2 IV every 21 to 28 days

Cat: 180 - 250 mg/m2 IV every 21 to 28 days
FORMULATION: 50 mg/5 ml and 450 mg/45 ml MDV.
NOTE:
1. HUMAN PRODUCT
2. Advantages over cisplatin include: less enviromnental toxicity,
pretreatment diuresis not required, lower renal toxicity.
Carprofen RIMADYL
USE: A non-steroidal anti-inflammatory drug (NSAID), the same type

that includes ibuprofen, naproxen, and ketoprofen. Shows
greater selectivity for COX II inhibition than COX I (in vitro)
Indicated for the relief of signs associated with osteoarthritis in
dogs, and for the relief of pain and inflammation in dogs.
DOSE: Dog: 1 mg per pound PO, SQ ql2h, OR 2 mg per pound PO, SQ

q24h. For control of post-operative pain, administer dose
approximately 2 hours before procedure.
- 39 -
Horse: 1 mg/kg PO q24h
FORMULATION: 25 mg, 75 mg, 100 mg oblong, scored tablets; 50

mg/ml solution for injection in 20 ml MDV (stored
in refrigerator - discard contents 28 days after first
entry into vial)
NOTE: DO NOT USE IN CATS

Owners should be advised to watch for signs of intolerance of
the medication: inappetence, vomiting, diarrhea, melena,
PUIPD, jaundice, lethargy, ataxia, seizure or behavior changes.
Aspirin containing products &/or other NSAIDS should not be
used while treating with carprofen.
Cefadroxil CEF A-TABS, CEF A-DROPS
USE: First generation cephalosporin antibiotic
DOSE: Dog, Cat: 11 to 22 mg/kg PO BID
FORMULATION: 50 mg/ml in 15 ml bottle with calibrated dropper
NOTE:
1. Oral suspension stable for 14 days after mixing; must be
refrigerated.
2. Vomiting is a common side effect. Giving with food
recommended.
Cefazolin Sodium generics
USE: First generation cephalosporin, bactericidal
DOSE: Dog, Cat: 15 to 35 mg/kg IV q6 to 8h

Horse: 20 mg/kg IV q6h (MacKay)
FORMULATION: I gram vial for reconstitution (stable for 24 hours

at room temperature, and for 10 days in
- 40-
refrigerator. Stability varies from manufacturer to

manufacturer. )
20 gram vial for reconstitution (to reconstitute -

add 87 ml {results in 200 mg/ml} of Sterile Water
for Injection, 0.9% Saline Injection. Refer to insert
for diluents for further dilutions. **20gm vial
SPECIAL ORDER only**
Reconstituted solutions may range in color from

pale yellow to yellow with no change in potency;
solutions should be inspected for particulate matter
prior to use.
NOTE: HUMAN PRODUCT. Protect from light
Cefepime MAXIPIME
USE: A 4th generation cephalosporin for treatment of susceptible

bacterial infections. Improved efficacy against Enterobacter and
Pseudomonas spp in neonatal foals.
DOSE: Neonatal foals: 11 mg/kg IV q8h, administer over 30 minutes
FORMULATION: 2g vial
NOTE:
1. HUMAN PRODUCT.
2. Stability: When mixed to concentration between 1 and 40 mg/ml
with 0.9% saline, 5% dextrose, Normosol-R, solutions are stable
for 24 hours @ room temp (68 to 77F) or 7 days in refrigerator
(36 to 46 OF)
Cefotaxime CLAFORAN
- 41 -
University of Florida" .. " .......... " .... "." ............. Veterinary Medical Center
USE: A third generation cephalosporin (injectable only); requested for

neonatal foals with gram-negative sepsis unresponsive to
conventional antibiotics.
DOSE: Neonatal Foal: 40 mg/kg IV q6h. Inject over a minimum of 3 to

5 minutes, or may be diluted for infusion (reconstitute with
D5W or 0.9% saline)
FORMULA nON: Available in 109 bottle for reconstitution

(refrigerate, discard any remainder after 7 days).
NOTE: Refer to package insert for freeze/thaw instructions, stability and

compatibility information.
Cefovedn CONVENIA
USE: A third generation cephalosporin, approved for dogs with

secondary superficial pyoderma, abscesses, and wounds in dogs
caused by susceptible strains of Staphylococcus intermedius,
Streptococcus canis (GroupG); in cats for wounds and absccsses
caused by susceptible strains of Pasturella multocida.
DOSE: Dogs, Cats: Greater than 4 months of age: 8 mg/kg SQ.
FORMULAnON: Reconstituted to 80mg/ml.
NOTES:
1. Therapeutic drug concentrations persist for 7 to 14 days,
depending on infectious agent (refer to insert)
2. Solution may change in color from pale yellow to amber over 28
days.
3. Refrigerate, protect from light, discard 28 days after mixing
Ccfoxitin
USE: A second generation cephalosporin, effective against anerobes,

including Bacteroides; for dogs and cats
- 42 -
DOSE: Administer IV over 3 to 5 minutes or as CRl; refer to Plumb's

V cterinary Drug Handbook
FORMULATION: I gram vial
NOTE:
1. Reconstitute with 10 ml of diluent resulting in 10.5ml of final
volume = 95.2mg/ml. Diluents for initial reconstitution are:
water for inj, bacteriostatic water for inj ,0.9% saline for inj, or
D5W. The resulting solution is stable for 6 hours @ room temp
or 7 days if refrigerated. The concentrated solution should be
fi.!rther diluted in 50 to 1000ml, potency maintained for an
additional 18 hours @ room temp or an additional 48 hours if
refrigerated. Suitable diluents for further dilutions are:
.. 0.9% saline for inj
.. D5W orDlOW
.. D5W + 0.9% saline
.. D5W + 0.45% saline
.. LRS
.. 5% Sod Bicarb
2. Painful if administered 1M.
3. Patients in renal failure may requires dosage adjustments.
Cefpodoxime proxetil SIMPLlCEF
USE: A third generation cephalosporin
DOSE: Dog: 5 to 10 mg/kg PO q24h for 5 to 7 days, or 2 to 3 days after

cessation of clinical signs, up to a maximum of 28 days. May be
given with or without food.
FORMULATION: 100 mg and 200 mg tablet
Ceftazidime FORT AZ, T AZICEF
USE: Third-generation, bactericidal cephalosporin
- 43 -
DOSE: Dog: 500 to 1000 mg IV q8h for large size dogs.

Snakes: 20 mg/kg q72h
:Foals: 20 to 25 mg/kg IV or 1M q8h
FORMULATION. 2 gram vial for reconstitution
NOTE:
l. HUMAN PRODUCT. VelY expensive.
2. Powder and solutions may darken on storage, however potency
is not adversely affected.
'1
.1. Has caused phlebitis when given IV push in canines.
4. PROTECT FROM LIGHT.
Ceftiofur Sodium NAXCEL
USE: Respiratory disease and shipping fever in cattle; swine

respiratory disease; equine respiratOlY infections; urinary traet
infections in dogs; E. Coli associated with early chick mortality;
canine urinary tract infections associated with E. Coli and P.
Mirabilis.
DOSE: Dog: 2.2 mg/kg SQ q24h for 5 to 14 days

Cattle: 1 to 2 mg/kg 1M q24h for 3 treatments, additional
doses may be given on day 4 and 5 if needed.
Horse: 2.2 to 4,4 mg/kg IM q24h; per manufacturer - treatment
should not exceed 10 days
Neonatal Foal: 5 mg/kg IV q12h OR 5 mg/kg 1M q12·~ 24h
FORMULA TlON: 1 gram and 4 gram vials, powder for reconstitution

to 50 mg/ml, with sterile water for diluent; 50
mg!ml ready to use suspension (EXCENEL RTU -
do not stock)
NOTE:
I. Reconstituted product is stable if refrigerated at 36° to 46°F for
7 days or at 59° to H6° F for up to 12 hours. Do not use D5W for
diluent - will cause viscous gel formation (per Pharmaeia).
2. PROTECT FROM LIGHT.
- 44-
University of Florida .... " .................... " ........ " .. Veterinary Medical Center
3. Residue wamings: no pre-slaughter drug withdrawal period is

required; no milk discard time is required, when product is used
as labeled.
4. EXCENEL RTU - for IM or SQ in cattle; 1M in swine. DO
NOT USE IN HORSES.
CephaJexin
USE: First generation cephalosporin, bactericidal
DOSE: Dog, Cat: 30 mg/kg PO q 12h

Psittaeines, ducks, pigeons: 35 to 50 mg/kg PO QrD
FORMULATION: 250 mg, 500 mg capsule; 125 mg/5 1111 in 100 ml

bottle and 250 mg/5 ml in 100 ml bottle. Stable for
14 days - refrigerate after reconstitution (only
stable for up to 8 hours if left at room temperature
~ Ranbaxy brand)
NOTI;:: HUMAN PRODUCT
Cephapirin Sodium CEFA-LAK, TODAY
USE: A first generation cephalosporin for use in lactating cows for

treatment of mastitis due to susceptible strains of Streptococcus
agalactiae and Staphylococcus aureus.
DOSE: Cow: one syringeful in affected qUaJ1cr q 12h for 2 treatmcnts
FORMULATION: 10 ml syringe equivalent to 200 mg cephapirin
NOTE:
L Milk taken during treatment and for 96 hours after last treatment
must not be used for food.
2. Animals must llot be slaughtcred for food until 4 days after last
treatmcnt.
45
Charcoal Activated, Sorbitol, Kaolin TOXIBAN, TOXIBAN with

Sorbitol
USE: An adsorbent used in poisonings; inhihits absorption of the

drug/chemical by the gastrointestinal mucosa.
DOSE: Dog, Cat: Givc via stomach tube, cither as is or mixed with a
small amount of cold water. Administer 10 to 20 ml per kg (5 to
10 tnl per pound). Rinse the container holding the suspension
and administer rinsings. Repeat with lower dose every 6 to 8
hours for 3 treatinents.
FORMULATION: 240 ml bottle
NOTE:
1. Induce emesis before giving activated charcoal.
2. Do not administer concomitantly with symp of ipecac.
Chew StOI! Bitter Apple
USE: Prcvention of chewing in dogs and cats
FORMULA TION: 8 oz liquid in spray bottle
Chlorambucil LEUKERAN
DOSE: Dog, Cat: 2 to 4 mg/m 2 PO q2days; For CLL: 6 mg/m 2 PO

q24h or 20 mg/m 2 PO q7days
CONTRAINDICA nONS: Ncutropcnia <2,OOO/f-tl and

thrombocytopenia <80,OOO/J..Ll.
TOXICITIES: This dmg is relatively nontoxic. Expected toxicities

includc a mild ncutropcnia and thrombocytopcnia,
nadir of7 to 14 days. Following discontinuation of
drug, lcukogram recovery noted in 10 to 14 days.
- 46 -
Syndrome of bronchopulmonary dysplasia and

pulmonary fibrosis similar to that seen with busulfan.
Run CBC every 1 to 2 weeks until stable.
FORMULATION: 2 mg sugar-coated tablet; new formulation-

requires refrigeration
NOTE:
1. HUMAN PRODUCT
2. Very poisonous - Do not allow contact of powder with skin. Do
not inhale powder or particles. Do not cut tablets to expose
powder.
Chloramphenicol Ophthalmic
DOSE: Ophthalmic: Use in eye TID to QID
FORMULATION: Sterile ophthalmic ointment 1% in 3.5 gram tube
NOTE:
1. Do not use in food animals.
2. Use caution when handling products containing
chloramphenicol.
3. WEAR RUBBER GLOVES WHEN HANDLING
Chloramphenicol
USE: Bacteriostatic antibiotic
DOSE: Dog: 25 to 50 mglkg PO, IV, 1M, SQ qSh

Cat: 25 to 50 mg/kg PO, IV, 1M, SQ q 12h
Snakes: 50 mg/kg q12 to 72h depending on species
Psittacines: 50 mglkg PO TID; 50 mg/kg 1M TID (propylene
glycol base); SO mglkg 1M TID (succinate)
Macaws, Conures: 50 mg/kg 1M QID (propylene g
lycol base)
Bald Eagle, Peacock: 50 mg/kg SID, BID
Horse: 25 mglkg q6 to Sh IV, 1M
- 47-
FOl"tci\.1ULATION: 500 mg tablet, 1000 mg tablct; 1 gram vial for

injection to be reconstituted (as sodium succinate).
Solution is stable at room temperature for 30 days.
NOTE:
1. Use caution when handling products containing
chloramphcnicol.
2. Do not use in food animals.
3. Can cause bone marrow suppression in cats when used for
treatment duration of greater than 2 weeks.
4. WEAR RUBBER GLOVES WHEN HANDLING
5. Do not CRUSH tablets
6. To mix for administration to horses: Place tablets in large
capped syringe, add water, allow to dissolve with shaking.
Prepare as usual for administration.
Chlorhexidinc NOLVASAN, ResiCHLOR, ResiKETOCHLOR
USE: A disinfectant effective against a variety of vegetative Gram

positive and Gram negative bacteria. Ineffective against acid-
fast bacteria. Some pseudomonas species can live in
chlorhexidine solutions unless 7% ethanol is added.
DOSE: Wound irrigating solution: dilute 2% Nolvasan solution in

sterile water to 0.05% (24 mllliter) and use to flush affected
arcas.
Psittacines: for treatment or prevention of candidiasis when on

long term antibiotic tbcrapy, 10m! per gallon of water
FORMULATION:
1. Chlorhcxidine diacetate: 2% solution (Nolvasan Solution);
2. Chlorhcxidine gluconate: 0.12% oral solution
0.3% Chlorhexidille Flusb 80z; ResiChlor (2%), ResiKetoChlor
(2,3%)
3. Chlorhexidinc acetate 1% ointment - can be ordered
NOTE:
- 48 -
1. Chlorhexidine should NOT be used on perforated ear drum,

brain, or meninges. Ototoxic; irreversible nerve damage may
result.
2. Can be irritating to tissues.
Chlorhexidine gluconate 2.3%, Ketoconazole 1%, Spherulites,

chitosanide KETOCHLOR Medicated Shampoo
USE: An antiseptic shampoo used to aid in management of bacterial

pyoderma and/or malassezia dermatitis.
DOSE: Dogs, cats, horses: Wet coat, lather, and allow 5 to 10 minutes
contact time before rinsing. May use initially 2-3 times per week
for 4 weeks, and then reduce to once weekly. SHAKE WELL
BEFORE USE.
FORMULATION: 80z. bottle
Chlorhexidine gluconate 2.3%, Ketoconazole 1 %, Spherulites,

chitosanide RESlKETOCHLOR Leave-On Lotion
USE: An antiseptic leave-on lotion, for dogs, cats, horses
DOSE: After bathing, or wetting the coat, apply as needed, massage into
skin and hair coat. Wash hands after using
FORMULATION: 80zbottle
Chlorhexidine 3%, phytosphingosine salicyloyl (0.05%), Lipacide R

C8G (2.5%), DOUXO Shampoo
USE: For dogs and cats with folliculitis due to bacterial infection with
underlying allergic dermatitis due to poor barrier function of skin
DOSE: Wet coat with warm water, lather, allow to sit 5 to ] 0 minutes,
rinse well
- 49-
FORMULATION: 500 ml
Chlorpromazine HCI
USE: Phenothiazine, used as a broad spectrum anti-emetic
DOSE: Dogs, Cats: 0.2 to 0.5mg/kg 1M, SQ, IV q8h
FORMULATION: 25 mg/ml, 1 ml ampule
NOTE: For IV use, dilute to Img/ml and give slowly
(Human) Chorionic Gonadotropin HCG, CHORULON
DOSE: Bovine: 10,000 units as a single deep 1M injection

Horse: 2,500 units IV
FORMULATION: 10,000 u/vial for reconstitution.

CHORULON should be used immcdiately aftcr
reconstitution, do not store unused portion for
future use.
NOTE: 0.1 mg = I international unit
Ciprofioxacin 0.3% Ophthalmic Solution
USE: A fluoroquinolone antibacterial agent for use in resistant

infectious keratitis.
DOSE: One drop in eye q2 to 6h depending on severity of ulcerative

condition.
FORMULA nON: 0.3% solution, 5 ml dropper tip bottle
NOTE: HUMAN PRODUCT
- 50 -
University of Florida .............................. " ........ Veterinary Medical Center
USE: Supplement for casein based enteral diets for cats
DOSE: Cats: 500 mg/day
FORMULATION: Crystalline, 99%
Clarithromycin
USE: A macrolide antibiotic for the treatment of Rhodococcus equi or

Streptococcus equi subspecies zooepidemicus infection.
DOSE: Foal: 7.5 mg/kg PO q12h (Giguere)
FORMULA TTON: 250 mg tablet
Clindamycin ANTlROBE, CLINTABS, generic
USE: Treatment of susceptible anaerobic bacterial infections, and

toxoplasmosis in dogs and cats.
DOSE: Dog, Cat: 5.5 mg/kg up to 11 mg/kg PO q12h

For toxoplasmosis, Dog: 11 mg/kg PO q12h
For toxoplasmosis, Cat: 10 to 40 mg/kg per day PO divided into
a qgh schedule.
FORMULATION: 25 mg and ISO mg capsules, 75 mg tablet, 25

mg/ml oral liquid in a 20 ml bottle with dropper
(most cats find liquid unpalatable); 300mg vial
Clostridium Botulinum (Polyvalent) Antitoxin
USE: For treatment of botulism in horses
- 51 -
DOSE: Horses: 250 ml per foal, 500 ml per adult horse. Administer
SLOWLY IV, using same set used to administer plasma.
FORMULATION: 2 x 250 ml frozen bags.
Clomipramine CLOMICALM
USE: A tricyclic antidepressant, which acts in the CNS to inhibit re-

uptake of serotonin. It is approved for use as part of a behavioral
management program to treat separation anxiety in dogs greater
than 6 months of age. It may also be used to alleviate
inappropriate barking, destructive behavior, and inappropriate
elimination, in conjunction with behavior modification. It may
be used in cats (not FDA approved for cats) for urine marking
and compulsive disorders.
DOSE: Dog: 2 mg/kg to 4 mg/kg per day - divide this dose and
administer BID
Cat: 0.5 mg/kg per day - divide this dose and administer
BID
Doses may be administered with a small amount of food. It is
recommended that the dose be tapered with continued
monitoring.
FORMULATION: 20 mg, 40 mg, and 80 mg tablets
NOTE:
1. Many potential drug and disease interactions. Review before
prescribing.
2. Should not be used in male dogs used for breeding.
3. Should not be used in dogs with seizure disorders or with other
drugs that may lower the seizure threshold.
4. Safety in pregnant or lactating dogs has not been established.
5. Safe use for more than 12 months has not been evaluated.
Clotrimazole 1%
- 52 -
USE: A broad spectrum antifungal agent with primary action against

dividing and growing organisms
DOSE: Large dog: for nasal aspergillosis - bilateral nasal infusion of 1

gram total clotrimazole (in 100 ml volume)
FORMULATION: Available as 1% solution (10 mg/ml) in non-

aqueous vehicle of polyethylene glycol 400; 30 ml
bottles; 1% cream 15g tube
Cobratoxin
USE: A reversible, post-synaptic receptor inhibitor
FORMULATION: 1 mg lyophilized powder per vial
Colloidal Oatmeal. Sunflower Oil ResiSOOTHE Leave-On Lotion
USE: To provide temporary relief of dry, irritated, itchy skin in

dogs, cats and horses of any age.
DOSE: After bathing or wetting the coat, apply as directed,

massage into skin and hair coat. Wash hands after using.
FORMULATION: 8ozbottle
Colon Electrolyte Lavage Solution COLYTE, GO-LYTELY
USE: Evacuation of the whole bowel for gastrointestinal examination
DOSE: 80 ml/kg PO via stomach tube in divided, equal doses given at

least 1 hour apart. Colonic evacuation can be hastened with an
enema and with concurrent bisacodyl therapy. Allow at least 12
hours from administration to colonoscopy. Walk dogs regularly
and place in run. Be sure cats have litter.
- 53 -
The solution occasionally causes vomiting. If this occurs give

metoc1opramide 0.5 mg/kg slow IV 5 minutes before repeating
the dose of colonic lavage solution.
The solution is isotonic and iso-osmotic and causes no

dehydration or electrolyte imbalance.
FORMULATION: Order by the ml- pharmacy requires 30 minutes

preparation time. Contains PEG, sodium chloride,
potassium chloride, sodium bicarbonate, sodium
sulfate (a total of69.5 grams of powder dissolved
in water to 1 liter final volume).
Copper Naphthenate 37.5% KOPPERTOX, CUPRINOX
USE: Topical antibacterial and antifungal
FORMULATION: 16 oz bottle - Special order only.
NOTE: May cause hair loss if contact occurs - use sparingly.
Cyanocobalamin Vitamin 812
USE: Vitamin B12 is essential to growth, cell reproduction,

hematopoiesis, and nucleoprotein and myelin synthesis.
DOSE: Dog, Cat: 250 mcg to 500 mcg per week, 1M or SQ
FORMULATION: 1000 mcg/ml
Cyclophosphamide
USE: Antineoplastic and immunosuppressive agent
DOSE: Dog, Cat: 50 mg/m2 PO QD for 4d and repeated weekly; or 200
- 54-
mg/m2 IV q7d. May be given PO, IV, 1M or intracavitary. Dose

adjustment may be required based on serum creatinine
concentration.
FORMULATION: 25 mg and 50 mg tablets; 500 mg vials
NOTE:
1. HUMAN PRODUCT
2. Tablets should not be cut - may loose potency (active ingredient
is is a small inner tablet encased in the outer tablet shell). For
smaller doses, the manufacturer recommends using injection in
aromatic elixir.
CONTRA INDICA TIONS: Pregnancy, neutropenia <2000/111,

thrombocytopenia <80,000/111 and previous
incidence of cyclophosphamide-induced
hemorrhagic cystitis.
TOXICITIES: Leukopenia, thrombocytopenia, and gastroenteritis;

when administered as bolus dose q21d, leukopenia
nadir 7 to 14 days post dosage with recovery noted by
21 days. Metabolite of cyclophosphamide may induce
sterile hemorrhagic cystitis and/or transitional cell
carcinoma ofthe bladder. Drug best given in the
morning to pernlit patient several opportunities to
effectively void the metabolite from the bladder lumen.
Some clinicians concurrently prescribe prednisone the
mornings of cyclophosphamide administration to
induce an associated polydipsia and polyuria.
DRUG INTERACTIONS: Phenobarbital therapy increases ilie rate of

metabolism and leukopenia activity of
cyclophosphamide. Allopurinol and thiazide-
type diuretics enhance bone marrow toxicity.
COMMENTS: Frequently used concurrently or sequentially with oilier

antineoplastic drugs. Must be activated by the liver and
is excreted primarily by the kidney. Metabolites are
protein bound. Dosage adjustment may be necessary in
states of hypoproteinemia or hypoalbuminemia.
- 55 -
University of Florida ........ " ...... " ........ " .... " ...... Veterinary Medical Center
Cyclosporine ATOPICA, NEORAL, SAND IMMUNE
USE: Immunosuppressant (primarily cell-mediated immunity) used in

the treatment of immune diseases such as graft rejection in renal
transplant patients, anal fistulas, immune-mediated hemolytic
anemia, inflammatory bowel disease, feline asthma. ATOPICA
is approved for use in dogs (>4 Ibs and >6 moths) for atopic
dermatitis.
DOSE: Absorption from the intestine varies widely between patients

and between preparations so dose should be individualized for
each patient based on clinical response and measurement of
blood concentrations >48 hrs after a changc of dose (ideal
trough scmm conccntration approx 200-500ng/mL) . Absorption
can be affected by food in the stomach so administcr orally two
hours before a meal. Bioavailability ofNeoral should be similar
to that of Atopica but is usually approximately twice that of
Sandimmune so recommended dose of Sandimmune dose is
usually approximately twice that ofNeoral. The following doses
are recommended starting doses:
Dogs: ATOPfCA for atopic dermatitis - 5 mg/kg (3.3-6.7

mg/kg) daily PO for 30 days then taper by decreasing
frequency to every other day or twice weekly.
Dogs, Cats: NEORAL or ATOPICA: Fistulas and immune

mediated diseases: 2 - 5 mg/kg PO q 12h.
Dogs,Cats: SANDIMMUNE: for acute kidney rejection in

transplant patients: 6.6mg/kg diluted with D5W to 50 mg/20 mL
of fluid volume given IV.
FORMULA nON:
Neoral-lOO mg/ml oral emulsion, 50 ml (discard any remaining 60 days
after opening bottle) human product;
Atopica - J0 mg, 25 mg, 50 mg, and 100 mg capsules - veterinary
product
Sandiruruune - 50 rug/ml inj in 5 ml ampule - human product mustdilute
- 56-
University of Florida ....................................... , Veterinary Medical Center
before administration - see package insert
NOTE:
1. Do not interchange between Sandimmune and Neoral:
Bioavailability is not equivalent between the two products. Per
Novartis - Neoral is equivalent to Atopica.
2. Dispense in glass if dispensing partial bottle amounts.
3. Sangcya, a generic for Neoral is no longer available.4. Review
drug therapy for drug - drug interactions.
4. Review drug therapy fir drug - drug interactions.
5. Vaccinate with killed vaccines.
6. Do not use in reproducing dogs, or dogs with malignant
neoplasia.
Cyclosporine 0.2% Ophth Ointment OPTIMMUNE
USE: Immunosuppressant; used in treatment of keratoconjunctivitis

sicca in canine
DOSE: Dog: Apply a 114 inch strip OU BID. One tube should last
approximately 5 to 6 weeks.
FORMULATION: 0.2% ophthalmic ointment, dispensed in 3.5 g tube
NOTE: BE SURE TO WIPE OVERFLOW FROM EYELIDS; WASH

HANDS IMMEDIATELY AFTER USE. Ointment should be
stored at 36° to 86°F.
Cyproheptadine
USE: An HI receptor antihistamine, which also has serotonin

antagonist properties. Has been used as an appetite stimulant,
and for the treatment of pituitary tumors in horses.
DOSE: Dog: Antihistamine - 1.1 mg/kg PO Q8 to 12H or 0.5 mg/kg

PO TID
Cat: Appetite stimulant - 1 to 2 mg/kg PO q 12 to 24h or 2
mg per cat q12h
- 57 -
Horse: 0.6 mg/kg PO initially, increase over several weeks to

1.2 mg/kg given in the morning.
FORMULATION: 4 mg tablet
Cytarabine (Cytosine Arabinoside) CYTOSAR-U, generic
USE: Lymphoma, CNS lymphoma
DOSE: Dog, Cat: 100 mg/m2 IV (as continuous infusion for 48 hours)
or 100 mg/ m2 SQ divided into 2 doses (Q12h) for 2
to 4 days (2 days in cats );or 20 mg/ m 2
intrathecally for 1 to 5d
Cat: Myelodysplastic/proliferative disease: 10 mg/m2
SQ q24h for 14 days.
May be given IV, SQ or intrathecally.
FORMULATION: 100 mg vial
CONTRAINDICATIONS: Neutropenia <2000/f..ll and thrombocytopenia

<80,000/f..ll
TOXICITIES: Leukopenia most commonly associated with prolonged

infusions; nadir 5 to 7 days with recovery noted 7 to 14
days. Other less common toxicities include nausea,
vomiting, diarrhea, abdominal pain, oral ulceration and
hepatic dysfunction.
COMMENTS: Acute pancreatitis has occurred in patients treated with

cytosine arabinoside who have had prior treatment with
L- asparaginase. Will cross the blood brain barrier.
Dacarbazine (DTIC)
USE: Rescue agent for refractory canine lymphoma. Alkylating

agent.
- 58 -
DOSE: Dogs: 800-1000mg/m2 as an IV CRI over 2 to 4 hours. Repeat

every 3 weeks.
FORMULATION: 200mg vial
CONTRAINDICATIONS: Neutropenia ::;2500/111 or thrombocytopenia

::;100,000/111
TOXICITIES: Thrombocytopenia is principal toxicity; nadir 7-14

days after treatment. Neutropenia nadir 7 days after
treatment. Mylesuppression is dose related; may
decrease or delay dose depending on grade of
myelosupression. Less serious toxicities include
anorexia, vomiting, lethargy. Gastrointestinal adverse
effects appear soon after infusion and persist for 12-24
hours.
Dactinomycin COSMEGEN
USE: A cytotoxic antibiotic used in the treatment oflymphoma,

sarcomas (also known as actinomycin D)
DOSE: Dog: 0.5 - 0.7 mg/m2 IV q7days
FORMULATION: 0.5 mg per single dose vial for reconstitution-

very limited availability from manufacturer
NOTE:
l. Sterile water, preservative free must be used for reconstitution.
2. SPECIAL ORDER - due to prohibitive cost.
TOXICITIES:
1. Anemia, neutropenia and thrombocytopenia may occur.
2. Gastrointestinal.
3. Caustic if administered perivascularly.
Dantrolene DANTRIUM
- 59 -
USE: Skeletal muscle relaxant, direct acting; also for treatment of

malignant hyperthermia.
DOSE: Dog, Cat: malignant hyperthermia: 1 to 10 mg/kg IV
Horse: aeute myopathy: For maintainanee: Give 10 mg/kg

PO loading dose, then 2.5 mg/kg PO every 2 hours.
For prevention: 1 to 2 mg/kg PO once daily.
malignant hyperthermia: 1 to 4 mg/kg IV; 10 mg/kg
PO
Swine: malignant hyperthermia: 2 to 5 mg/kg IV
FORMULATION: 20 mg vial (stocked in anesthesia)
NOTE: HUMAN PRODUCT
Darbepoetin Alfa ARANESP
USE: A biosynthetic erythropoietic agent lIsed to treat anemia due to

chronic renal failure.
DOSE: Dog: 0.5mcg!kg once every 7 days.

Cat: 5 mcg/cat oncc cvcry 7 days.
FORMULATION: 100mcg/lml vial, PRESERVATIVE-FREE
Deracoxib DlmAMAXX
USE: A non-stcroidal anti-inflammatory dmg (NSAID) of the coxib

class for use in dogs only. In vitro studies indicate COX.·2
activity, while sparing COX-1. Use for control of post-operative
pain and inf1ammation associated with orthopedic surgery, and
osteoarthritis pain and inflammation.
DOSE: Dog: Osteoarthritis pain: 1 to 2 mg/kg once daily

Orthopedic post-op pain (in dogs greater than 4 pounds): 3
to 4 mg/kg once daily not to exceed 7 days
- 60 -
University of Florida ........................................ Veterinary Medical Centcr
FORMULATION: Beef-flavored chewable tablets, 25 mg and 100 mg

half-scored, round tablets.
NOTE: Monitor patients for renal and GI toxicity. Aspirin containing

products &/or other NSAIDS should not be used while treating
with deracoxib.
Deslorelin Implant OVUPLANT
USE: Sustained release gonadotropin releasing hormone (GnRH)

analog for ovulation induction in mares
DOSE: Horse: one implant per maTe during a given estrus
FORMULATION: 2.1 mg implant with pTeioaded implanter

(refrigeration required). SPECIAL ORDER
Desmopressin Acetate lni
USE: A synthetic analog of natural pituitary hormone 8-arginine

vasopressin (ADH) Indicatcd for treatmcnt of patients with central
diabetes insipidus in small animals and also causes smaller
increases in factor V-Tn-related antigen and ristocetin cofactor
activities.
DOSE: Refer to Plumb's Veterinary Drug Handbook
FORMULA TION: 4 111cg/ml- 1 1111 ampule or vial; stored in

refrigerator
Desoxycorticosterone Pivalate PERC ORTEN-V
USE: Mineralocorticoid replacement therapy for primary and

secondary adrenocortical insufficiency in Addison's disease and
for the treatment of salt-losing adrenogenital syndrome.
- 61 -
University of Florida" ...................................... Veterinary Medical Center
DOSE: Dogs: 1.5 to 2.0 mg/kg 1M every 25 to 30 days.
FORJ\rIULATION: 4 ml multi-dose vials 25 mg/ml for 1M injection
NOTE: Prednisone needed to provide glucocorticoid requirements.
Detomidine DORMOSEDAN
USE: Alpha-2 sympathetic agonist which produces profound sedation

and analgesia in horses
DOSE: Horse: 0.005 to 0.02 mg/kg TV
FORMULATION: 10 mg/ml for injection in 5 ml vials
NOTE: May usc yohimbine to reverse the effects of detomidine; usc

cautiously at initial dose of 0.03 mg/kg
Dexamethasone
USE: Steroid responsive inflammatory conditions
DOSE: Dogs, Cats: 0.1 to 0.2 mg/kg 1M or IV q12 to 24h

Psittacines, Raptors: 0.4 to 2 mg/kg IV, 1M, SQ, PO pm
Horse: 0.02 to 0.2 mg/kg IV, IM, PO
FORMULA TION: Veterinary labeled product: 2 mg/ml for injection

J00 ml vials; 0.75 mg tablet.
NOTE:
1. Large parenteral doses have been associated with
gastrointestinal bleeding and colonic perforation.
2. The use of dexamethasone is a risk factor for development of
laminitis in horses.
Dexamethasone sodium phosphate
- 62 -
University of Florida .............. " ......................... Veterinary Medical Center
USE: Steroid responsive inflammatory conditions of rapid onset and

short duration
DOSE: For IV or 1M use, 4 mg/kg
FORMULATION: Human product: 4 mg/ml for injection (equivalent

to 3 mg dexamethasone), 30 ml multi-dose vial.
NOTE: Protect from light
Dexmedetomidine DEXDOMITOR
USE: An alpharadrenoreceptor agonist with sedative and analgesic

properites.
DOSE: Dog: Sedation: 10 - 20 mcg/kg 1M OR

2-5 mcg/kg IV
Note: Usual IV dose for sedation is 2-5mcg/kg IV. May
go as high as 2-1 Omcg/kg IV. Increase in dose will result
in longer duration of sedation. but not an incrcase in
level of sedation.
CRI for post-op sedation: 0.25 . - 2.5mcg/kg/hour. Dilute

Lo 10mcg/ml with 0.9% saline. Use the least possibJe
dose to provide sedation; adjust rate based on dog's
response.
Cat: Sedation: 20 - 40 mcg/kg 1M
FORMULATION: 500mcg/ml
NOTE:
1. It is recommended that dogs be fasted 12 hours prior to dose.
2. An eye lubricant should be applied to cats to prevent cOl11i~al
desiccation.
3. Dexmcdetomidine can be absorbed through skin, eye, and oral
mucosa may be ilTitating and may produce systemic effects
wash area, remove contaminated clothing, seek medical attention
immediately.
- 63 -
4. Use caution when handling sedated animals handling or sudden

stimuli may produce a defense reaction in an apparently heavily
sedated animal.
5. Doses submitted by UF VMC Anesthesia Service.
6. Atipamezole is reversal agent.
Dexrazoxane
USE: A derivative of EDTA, useful in the treatment of doxorubicin

extravasation, and as a cardioprotective agent for use in
conjunction with doxorubicin.
DOSE: For extravasation: use 30mg dexrazoxane: Img doxorubicin;

administer IV as a separate infusion (Milner)
FORMULA TION: 250mg single dose vial; stable for 6 hours at room
temp or refrigerated after mixing.
NOTE. Wear rubber gloves and handle as chemotherapy agent.
Dextrose
USE: Treatment of hypoglycemia
DOSE: Dog, Cat: Give 0.5 gm/kg IV PUSH for emergency

hypoglycemia; or 1 mllkg ofD-SO-W.
Horse: 1 gram/kg in Jess than 20% solution for dextrose
tolerance test
Bovine: 500 to 1000 ml of 50% solution/WOO Ib for
treatment of ketosis IV
Psittacines, Raptors: Acute hypoglycemia: 1 glkg slow IV

bolus. Do not cxceed 132 mg/kg/hr IV
FORMULATION: Bulk powder, non-sterile; 50% solution for

injection in 50 1111 vial and 500 Illi bag
NOTE:
- 64 -
University of FloridL ...................................... Veterinary Medical Center
1. Severe tissuc irritation associated with extravascular injection of

hypertonic dextrose solutions.
2, By using D-50-W, a 2,5% dextrose solution can be made by
adding 12,5 ml to 250 ml ofNaCI 0,9% or LRS, Stronger
solutions can he made with proportionally increased amounts.
Diazepam
USE: A benzodiazepine used as an anxiolytic agent, muscle relaxant,

anticonvulsant, anesthetic premedication
DOSE: Dog: Anticonvulsant: 0.5 mg/kg IV bolus; repeat qlO minutes 3

times ifno effect; for CRr: nm diazcpam @ O,8ml
(5mg/ml diazepam) per 10 ml offluid/hour (Clemmons)
Anxiolytic: 0,5 to 1.5 mg/kg IV
Premed: 0.25 to 0,5 mg/kg 1M or IV
Sedation: Give 1 ml per 20 pounds of equal parts diazepam
5 mg/ml and ketamine 100 mg/ml
Cat: Spraying: 1 mg PO gl2h for 14 days, then 0,5 mg PO q12h

for 14 days, then 0.5 mg PO g2d for 14 days
Muscle relaxant: 1,25 to 2,5 mg PO BID
Horse: 0,03 to 0.25 mg/kg TV; repeat in]O minutes if

necessary
FORMULATION: 2 mg, 5 mg, 10 mg scored tablet; 5 mg/ml solution

for injection in 2 ml pre-filled syringe/vial, 10 ml
MDV
NOTE:
1. Controlled substance - C-JV
2, Give IV boluscs slowly (1 minute/5 mg).
3. May cause sphincter relaxation in post-obstructive cats
4. Maximum dose is 15 mg for canine
5. Appetite stimulant effect is of questionable efficacy
6. Insoluble in aqueous solutions
7. Precipitates when injected 1M
8, Adsorbs to PVC bags and tubing (ref. Handbook on Injectabe
Drugs 13 th editionp463)
- 65 -
Dicalcium Phosphate Powder (a mixture of monocalcium and

dicalcium phosphate)
USE: As a calcium supplcmcnt
DOSE: Refer to dermatology service for specific hypoallergenic diets
FORMULATION: Thc powder provides 19- 22.8'% calcium, 18.5%

(min) phosphorus, providing 11.63 mEq Calcium
per gram.
Available fi'om the pharmacy in 150 g containers.

There are approximately 40 level teaspoonsful in
each 150 g containcr. One Icvel teaspoonful
wcighs approximately 3.5 grams.
Diclofenac 0.1 % VOLTAREN, generic
USE: A non-steroidal, anti-inflammatory agent for ophthalmic use
DOSE: Dog, Cat: I drop in eye once daily to 4 times daily for uveitis.
FORMULATION: 2.5 ml or 5.0 ml dropper tip bottle
Diclofenac 1% SIJRPASS Cream
USE: A non-steroidal, anti··inflammatory (NSAID) agcnt for topical

application in horses; for control of pain and inflammation
associatcd with ostcoarthritis in tarsal, carpal,
mctacarpophalangeal, metatarsophalangeal, and proximal
interphalangeal joints.
DOSE: Horse: Apply a 5 inch ribbon of cream over the affected joint
BID; rub in well until the cream disappcars.
FORMULA TION: 124g tube
- 66-
University of Florida ............. ,..... ", ....... ,.... ,.. ,.. Veterinary Medieal Center
NOTE:
1. WEAR RUBBER GLOVES Wash hands after use,
2. One 5 inch ribbon delivers approximately a 73 mg dose.
3. Do not use with corticosteroids or other NSAIDS.
Digoxin LANOXIJ\
USE: Positive inotropic cardiac drug, antiaJThythmic drug for

supraventricular tachyrhythmias, especially atrial fibrillation
DOSE: Dog: LOADING doses are obsolete, Maintenance doses: 0.003-

0.005 mg/kg PO q12h or 0.22 mg/m2 PO q12h, LEAN
body weight must be used. Because of superior absorption
of the alcohol-based elixirs, the dose ofliquid digoxin
should also be reduced by 10 to 20%.
Cat: 0,007 mg/kg PO q24-48h; see Plumb's Veterinary Drug

Handbook for alternate dosing regimens
Horse: 0.06 to 0,08 mg/kg PO for digitalization, 0,01 to 0.02

mg/kg PO maintenance
FOR1\1lJLATlON: 0.125 tablet (scored); 0.05 mg/ml elixir, in 60 ml

bottle with calibrated dropper
NOTE:
1. Dosage recommendations are guidelines only and must be
adjusted to individual needs and tolerancc.
2, Serum digoxin levels must be measured 5 to 10 days after initial
dose. Draw level8-l0 hours after dosing. Therapeutic level: 0,5
to 1.5 nanogram/mL
3. With renal disease, the dosage should be reduced by 30 to 50%
for every doubling of the BUN,
4. HYPOthyroidism reduces digoxin clearancc, HYPERthyroidism
increases digoxin's myocardial effects.
5, Reduce dose by 50 to 75%, when using with quinidine.
- 67 -
SIDE EFFECTS: Nausea, anorexia, vomiting, diarrhea. ECG: AV-

blocks, ventricular bigeminy, any arrhythmia
DRUG INTERACTIONS:
1. Quinidine raises serum digoxin levels by competitive binding on
the receptor sites.
2. Antacids reduce the absorption of digoxin.
3. High doses of diuretics (furosemide) may raise serum digoxin
levels.
4. Phenylbutazone and Barbiturates may increase digoxin
clearance.
5. Chloramphenicol and Tetracyclines may decrease digoxin
clearance.
CONTRAINDICATIONS: Known digoxin intolerance, high grade AV-

blocks, severe hypokalemia
Dihydrotachysterol DHT
USE: Effective in the elevation of serum calcium by stimulating

intestinal serum calcium absorption and mobilizing bone
calcium in the absence of parathyroid hormone and functioning
renal tissue.
DOSE: Dog, Cat: 0.01 mg/kg/day increase to 0.02 to 0.03 mg/kg/dayas

necessary
FORMULATION: 0.2 mg/ml oral solution (20% alcohol)

November 2005 - discontinued by manufacturer
NOTE: Overdosing can cause hypercalcemia
Diltiazem CARDIZEM, DILACOR XR, generic
USE: Calcium channel blocker, used in the treatment of

supraventricular tachycardia and atrial fibrillation; in cats with
hypertrophic cardiomyopathy.
- 68 -
DOSE: Dog: 0.5 to 1.0 mg/kg PO TID; 0.4 to 0.9 mg/kg IV

bolus; or 10 to 30 mcg/kg/min fOT IV infusion
(experimental); elimination half·life is 1.7 hours.
Dilacor XR (or generic) .. 1.5 to 6 mg/kg PO BID.
Cat: 7.5 mg PO TID; OR ifusing Cardizem CD, 10

mg/kg PO once daily; 0.2 mg/kg IV or DilacoT XR
(or generic) - 30 to 60 mg/kg q12h to 24h
FORMULA TlON: 30 mg tablct; 240 mg XR capsule; 5 mg/ml

injection in 5 ml single dose vials (in refi·jgerator)
NOTE:
I. HUMAN PRODUCT
2. Diltiazem may result in decreased contractility and should be
used in caution in animals with severe myocardial failure.
3. CARDIZEM 30 mg tablet should not be cmshed or broken,
tablets time·release (over 2 to 4 hours) per Marion Merrell Dow
4. Dilaeor XR and some generics contain 4 x 60 mg pcllets inside
the capsule (pellets should not be cmshed)
5. Monitor for dmg interactions
6. 6. Best on an empty stomach
Dimercaprol BAL in Oil
USE: For the treatment of arsenic, gold, and mercury poisoning; and
in acute lead poisoning when used with edetate calcium
disodium injection
DOSE: Dog: For IMMITICIDE toxicity: 3 mg/kg 1M

Horse: 2.5 to 5 mg/kg 1M q4h for 2 days, then BID until
recovery.
FORMULATION: Available in 3 ml ampules, supplying dimercaprol

100 mg/ml, benzoyl benzoate 20%, in peanut oil·
SPECIAL ORDER
Dimethyl Sulfoxide DMSO, DOMOSO
- 69 -
USE: Anti-int1ammatory
DOSE: 1 gram/kg as a 10% solution given rapidly IV
FOIZl\1ULATION: 99% solution, 16 OZ; 90% gel, 120 g
Dinoprost tromethamine LUT ALYSE
USE: A prostaglandin used for uterine evacuation in pyometra, an

abortifacient and luteolytic
DOSE: Dog, Cat: Pyometra: 0.1 to 0.25 mg/kg SQ, QD for 5 days
Horst~: I mg/l 00 Ib 1M once
Bovine: 25 mg IM for luteolytic action
Swine: Sows - 10 to 12.5 mg 1M on no earlier than thc
111 th day of pregnancy, parturition should occur 22
to 34 hours post-injection
To cause abortion: 15 mg 1M followed in 12 hours by 10 mg 1M
Diphenhydramine HCL BENADRYL, generics
USE: An ethanolamine antihistamine, HI receptor blocker; useful for

therapy for acute allergic reactions (but not a substitute for
epinephrine) and to dcerease the likelihood of anaphylaxis-like
events associated with the administration of certain
antineoplastic agents. Thought to help reverse the nicotinic
effects of organophosphatc intoxication.
DOSE: Dog, Cat: 2 to 4 mg/kg PO q8h; 5 to 50 mg IV q 12h; 1.1

mg/kg 1M 15 minutcs prior to cCliain antincoplastic
drug administrations
Horse: 0.05 mg to I mg/kg TV
- 70 -
FORMULATION: 25 mg and 50 mg capsule; 50 mg/ml solution for

injection (order by ml or 10 ml vial)
NOTE:
1. HUMAN PRODUCT
2. Common side effects include sedation, CNS depression,
incoordination.
3. Use caution giving IV in dogs - administer over 1 to 2 minutes.
Diphenoxylate, atropine
USE: An opioid derivative used in the treatment of diarrhea and also

in the treatment of cough due to collapsing trachea in dogs.
DOSE: Dog: Diarrhea: 0.1 to 0.2 mg/kg PO q8h

Collapsing trachea: 0.2 to 0.5 mg/kg PO q l2h
FORMULATION: 0.5mg/ml diphenoxylate with atropine 0.005

mg/ml, a1cohoI15%; available in 60 ml bottle
(expires 90 days after opening)
Tablet, 2.5 mg diphenoxylate with 0.025 mg
atropine
NOTE:
l. Controlled - C-V.
2. Use in cats is poorly documented.
Dipotassium EDTA SEQUESTER-SOL
USE: To aid in the dissolution of corneal calcium deposits
DOSE: I drop 4 to 6 times daily
FORMULATION: Diluted in artificial tears solution to approximately

0.5%
Di-tri-octahedral (DTO) smectite BIO-SPONGE
- 71 -
USE: A natural hydrated aluminomagnesium silicate that binds to

mucosa in the digestive tract and increases resistance to
bacterial damage by binding toxins produced by C. difficile and
C. perfringens.
DOSE: Horse: Colitis: initially administer 3 pound dose via NGT,

then 1 pound dose every 6 hours. May also be
administered chronically at 1 pound twice daily.
FORMULATION: 4 pound jar; 60cc oral paste
NOTE: Studies indicate that BIO-SPONGE does not bind metronidazole
Dobutamine DOBUTREX, generic
USE: Positive inotropic drug (primarily B)-agonist) for acute CHF,

vasoconstrictor for hypotension
DOSE: Dog: 2.5 to 15 mcg/kg/min as CRI

Cat: 2 to 10 mcg/kg/min (usually 2 to 5 mcg/kg/min) IV
CRI.
Horse: 2 to 10 mcg/kg/min IV
Two useful drip concentrations are:

(125 mcg/ml): Add 10 ml dobutamine into 1000 ml D5W
(250 mcg/ml): Add 20 ml dobutamine into 1000 ml D5W
ECG-monitoring is advisable.
SIDE EFFECTS: Sinus tachycardia, VPC's and ventricular

tachyrhythmias at rates greater than 5 mcg/kg/min.
Vasoconstriction and hypertension with high doses.
Monitor for abnormal neurologic activity and seizures
in cats.
FORMULATION: 250 mg/20 ml single dose vial
Docusate Sodium, DSS, Dioctyl Sodium Sulfosuccinate
- 72-
USE: Surfactant, used as a laxative, ear wax softener
FORMULATION: 5% water miscible solution
NOTE: Capsules available over-the-counter at retail stores.
Domperidone EQUIDONE
USE: A dopamine antagonist with actions and uses similar to

metoclopramide. In veterinary medicine, used for the prevention
and treatment of fescue toxicosis and related agalactia in
periparturient mares.
DOSE: Fescue toxicosis: 5 ml per 500 kg mare body weight by mouth

daily, starting 10 days prior to the expected foaling date and up
to foaling. In some cases, dosing should be initiated 15 to 25
days prior to foaling. Treatment may need to be continued for at
least 5 days after foaling in some mares.
Agalactia: 5 ml per 500 kg mare body weight BID for 2 days,
then once a day for at least 3 more days.
FORMULATION: Available as 11 % oral gel, provides 5 doses for a

500 kg mare.
NOTE:
1. This is a gastrointestinal prokinetic drug, do not use in mares
with suspected or confirmed 01 blockage.
2. The use of this drug may cause a false positive reading on thc
milk calcium test used to predict foaling.
3. Contact Dr. Dee Cross with questions/comments 864-646- 2703
4. Available from Equi-Tox 864-646-6443
5. This is not an FDA approved product
Dopamine HCL
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University of Florida" ............. " ..... " ................ Veterinary Medical Center
USE: Vasoconstrictor for raising artcrial blood prcssurc, positivc

inotropic cardiac drug. Shock therapy after adequate volume
replacement. Selective increase of renal blood flow.
DOSE: Dopaminergic receptors: 1 to 3 mcg/kg/min, Beta receptors: 3 to

5 mcg/kg/min, Alpha receptors: 5 to 10 mcg/kg/min.
Dog, Cat: 2 to 5 mcg/kg/min as a continuous rate infusion

Horse: 1 to 20 mcg/kg/min: drip to effect
A useful drip concentration is 250 mcg/m!. To achieve this

concentration add 6.25 ml of dopamine into 1000 ml D5W.
FORMULATION: 400 rng/lO ml single dose vial; the drug should be

mixed just prior to usc, although it may be stable
up to 24 hours in a solution with pH less than 6.4.
NOTE:
l. HUMAN PRODUCT
2. ECG and blood pressure monitoring is advisable, as well as
urine flow.
3. Extravasation with dopamine can lead to necrosis and sloughing
of tissue.
SIDE EFFECTS: Tachycardias and arrhythmias may develop at

infusion rates greater than 5 mcg/kg/min.
Vasoconstriction and hypertension at high doses.
Dorzolamide 2% TRUSOPT
USE: Carbonic anhydrase inhibitor fonnulated for topical use in the

eye to decrease production of aqueous humor. resulting in a
reduction of intraocular pressure
DOSE: Place I drop in the eye TID
FORMULATION: 2'% solution in a 10 ml bottle with a droppcr tip.
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University of Florida ............. " ..... "" ................ Veterinary Medical Center
Doxapram HCL DOPRAM V
USE: Respiratory stimulant
DOSE: Horse: 0.5 to 1.0 mg/kg at 5 minute intervals. DO NOT

EXCEED 2 mg/kg in foals.
Neonatal foal resuscitation: 0.02 to 0.05 mg/kg/min
FORMULATION: 20 mg/ml in 20 lIll multi-dose vial
Doxorubicin ADRIAMYCIN, generic
USE: Sarcomas, lymphoma, other carcinomas
DOSE: Dog: 30 mg/m2 IV q2ld or 10 mg/m2 JV q7d to maximum

dosage 40 mg/m 2
Cat: 20 to 30 mg/m2 IV q21 d, or 25 mg/m 2 q21 to 28 days or 10
mg/m2 IV q7d to maximum dosage 240 mg/m2 ; reduce
dosc for renal insufficiency
Dose adjustment may be required based on bilimbinemia,

neutropenia or thrombocytopenia.
IV or diluted, intracavitary: Pretreat with 0.5 mg/lb

diphcnhydramine IM 15 minutcs prior to doxombicin
administration. Secure IV catheter and administer over 7 to 10
minutes at final concentration of 0.5 mg doxorubicin/ml sterile
saline. Flush catheter with sterile saline for injection. Caution:
(1) Heparin will precipitate doxorubicin. (2) If drug is
extravasated during injection severe cellulitis and/or slough may
occur.
FORMULATION: 10 mg and 50 mg vials, as 2 mg/ml solution
CONTRAINDlCATlONS: Cardiac arrhythmias, cardiomyopathy,

neutropenia <2000/p.l, thrombocytopenia
<80,000/pl and bilirubinemia >6.0 mg/dl.
TOXICITIES:
- 75 -
1. Cardiotoxicity manifested by progressive dilated

cardiomyopathy unrcsponsivc to mcdical management; this
phenomenon is dose dependent and generally does not occur
until a cumulative dose of 180 to 250 mg/ni. General guidelines
suggest that no more than 5 doses of 30 mg/m 2 be given, unless
clinical judgment dictates otherwise.
2. Anaphylaxis-like event has been reported following IV
injcction. Bc ccrtain to pretreat patient with diphcnhydramine,
dilute doxorubicin to 0.5 mg/ml sterile saline for injection and
administer slow over 7 to 10 min. If signs of anaphylaxis
develop, stop injection and treat appropriately.
3. Leukopenia and thrombocytopenia possible with nadir
responses noted 10 to 14 days post injection. Hemogram
recovery generally complctc by 21 days post injcction;
occasional rebound leukocytosis noted.
4. Gastrointestinal disturbance (manifested) by vomiting, dianhea
and anorexia) generally affects about 40% of patients 3 to 5
days post injection. The gastroenteritis is considered mild and
should be treated conservatively: bland diet and PeptoBismoi.
Occasional bloody dianhea has been noted. Treat with
PeptoBismol PO TID for 7 days has been effective. Pre-
treatment with 5 days of PeptoBismol has been reported to
prevent GJ signs.
5. Epilation and alopecia reported mostly in curly coated dogs.
Cats lose whiskers.
6. Nephrotoxic in cats at 30 mg/nl.
Doxycycline hyclate VlBRAMYCIN, generics
USE: A lipid-soluble tetracycline antibiotic, drug of choice for

Ehrlichia canis, Lyme disease. Treatment tor Chlamydiosis in
birds.
DOSE: Dog: EhrIichia canis acute: 5 mg/kg PO QD for 7 to 10 days

Ehrlichia canis chronic: 10 mg/kg PO QD for 7 to 10 days,
*follow dose with 6 ml of water
Tortoise: 50 mg/kg for first dose, then 25 mg/kg q72h
- 76··
Psittacines: 8 to 16 mglkg PO BID; 50 mglkg q72h

(cockatiels); 10 mglkg IV SLOW (do not use 1M - irritating)
Horse: 10 mglkg PO BID; DO NOT give parenterally to horses.
FORMULATION: 100 mg tablet; doxycycline (calcium) 10 mg/ml

oral suspension (raspberry/apple) flavored,
dispensed by the ml; 100 mg per vial for injection.
Has been imported for Zoological Medicine

Service (with FDA approval): long-acting
injection, 100 mg/5 ml amp Vibraveineuse by
Pfizer - check for availability.
NOTE: Do not inject 1M or SQ. Avoid rapid administration - minimum

infusion time for 100mg (0.5mgiml concentration) is 1 hour.
Edetate calcium disodium (EDT A) CALCIUM DISODIUM

VERSENATE
USE: Acute and chronic lead poisoning and lead encephalopathy
DOSE: Dog, Cat: 110 mglkg/day in divided doses SQ for 5 days; use
a 10 mg/ml solution in D5W
Horse: 1.1 ml (220 mg) per kg IV as a total daily dose;
may be divided q8 to 12h for 3 to 5 days. If further
treatment required, rest for 2 days, repeat for a
second 3 to 5 day therapy
Psittacines, Raptors: 27 to 35 mglkg 1M BID for 5 days, skip 5

days, repeat
NOTE:
1. HUMAN PRODUCT
2. Nephrotoxic. Use with caution in combination with other
nephrotoxic compounds.\
3. Should not be used for mercury poisoning because mercury is
carried to the kidney and released there (too weakly bound).
- 77-
4. Avoid concomitant administration of barbiturates or

sulfonamides.
5. Renal toxicity may be enhanced with co-administration of
glucocorticoids.
FORMULATION: 5 ml ampule, 200 mg/m!. Manufacturer

recommends a 24 hour expiration after the ampule
has been opened (concern is sterility - not
stability).
Edrophonium Chloride TENSILON, ENLON
USE: A short-acting anticholinesterase used in the differential

diagnosis of myasthenia gravis
DOSE: Dog: 0.1 to 0.2 mglkg IV

Cat: 0.5 to 1 mg IV
FORMULATION: 10 mg/ml in 15 ml MDV
Electrolytes, Oral HE-SORB
USE: Control of dehydration associated with diarrhea in calves
DOSE: Bovine: Scouring calves - give 2 quarts of solution BID for 2

days, then give 1 quart of solution with 1 quart milk
(milk replacer) for next 2 days.
FORMULATION: One packet to make 2 quarts of solution in water

provides: glucose 44 gram, sodium chloride 8.82
gram, potassium phosphate 4.2 gram, citric acid,
anhydrous 0.5 gram, potassium citrate 0.12 gram,
and aminoacetic acid (glycine) 6.36 gram.
NOTE: No buffering effect.
Emodepside / Praziguantel PROFENDER
- 78 -
USE: For treatment and control of ascarids, hookworms, and

tapeworms in cats and kittens at least 8 weeks of age.
DOSE: Part hair and apply entire contents of tube on skin on back of
neck at the base of the head as a one time treatement. May re-
apply after 30 days ifre-infection occurs.
FORMULATION: Topical solution available in the following sizes (4

tubes / box).
Cat Weight* Tube Volume Emodepside Praziquantel

2.2 - 5.5 Ibs Small 0.35ml 7.5mg 30mg
5.6······ 11 Ibs Medium 0.7ml 15mg 60.1mg
11.1 - 17.6 Ibs Large 1.12ml 24mg 96.1mg I
I
*Cats over 17.6lbs should be treated WIth appropnate
combination of tubes
Enalallli! V ASOTEC, ENACARD, generics
USE: An angiotensin-converting enzyme (ACE) inhibitor, used for

treatment of congestive heart failure, systemic hypertension,
renal disease.
DOSE: Dog, Cat: 0.25 to 0.5 mg/kg PO q12 to 24 h
FORMULATION: All sizes ofENACARD will be discontinued by

manufacturer by the end of 2008 if not before: all
strengths except lmg are available as HU MAN
generics. 2.5 mg, 5 mg, 10 mg and 20 mg tablets.
NOTE:
1. Should have less gastrointestinal side effects than captopril.
2. Overdose can cause weakness and syncope associated with
hypotension.
Enrofloxacin BA YTRIL
- 79 -
University of Florida ....................................... Veterinary Medical Center
USE: Quinolone antibacterial for the treatment of serious multi-

resistant gram negative infections.
DOSE: Dog: 5 to 20 mg/kg PO Q24H or may divide dose and give BID:
for 10 to 30 days
Cat: 5 mg/kg PO Q24H, or divide dose and administer Q12H
Box Turtle: 5 mg/kg IM q96 to 120h
Hermann's Tortoise: 10 1M mg/kg q24h
Horse: 7.5 mg/kg PO q24h; or 4 mg/kg PO q12h; or 5 mg/kg
SLOW IV q24h
Cattle: Give one dose SQ of7.5 to 12.5 mg/kg OR give one
dose SQ of2.5 to 5 mg/kg q24h for 3 days; if necessary
may give additional doses on day 4 and day 5.
FORMULATION: Tablets: flavored 22.7 mg, 68 mg, 136 mg; 68 mg

purple tab (non-llavored); oral suspension
20 mg/ml (compounded from purple tablets-
suspension has lA day expiration date);
Small Animal Injection: 22.7 mg/ml injection, 20

ml vial;
Cattle Injection: 100 mg/ml, 100 ml vial
NOTE:
1. CONTRAINDICATED in immature animals. May cause
articular cartilage damage.
2. Safety in breeding bitches not established.
3. Small animal injection is approved for [M only.
4. This product is NOT approved by FDA for usc in horses.
5. Not for use in cattle intended for dairy production or in calves to
be processed for veaL Meat withdrawal time is 28 days from last
treatment.
6. In cattle, do not exceed 20 ml per injection site.
7. Baytril inj 100 mg/ml should be given SLOWLY or may be
diluted prior to administration. Stability is a potential problem
(due to arginine base) and crystals form easily. Check for
particulates before administering drug. May usc saline to dilute,
discard any remaining after 24 hours (per manufacturer).
8. Avoid use of Baytril lOOmg/ml via any route (1M, IV, SQ, PO)
in small animals. The high pH (approx 11) and benzyl alcohol
- 80
University of Florida ................. " ....... " ... ".""" Veterinary Medical Center
content of this formulation can cause serious advcrse rcactions

(abscesses, sloughing, tissue irritation and injury, injection site
reactions potentially leading to leg amputation,
thrombophcbitis).
9. Cat doses in excess of 5 mg/kg may result in mild to severe
retinal and/or visual changes, the most severe being blindness.
10. The 22.7 mg/ml injection has been diluted 3 parts salinc to I
part Baytril to be given IV to dog.
11. Wash hands after use.
12. Usc with caution in animals with known or slIspected CNS
disorders - rarely may precipitate seizures.
13. Check for food-drug interactions, and drug-drug interactions.
14. Oral suspension is compounded from purple tablet following
proccdure in Plumb's Veterinary Drug Handbook 5th Edition.
Refrigerate, discard after 14 days.
Enteral Nutrition CLINICARE CANINE/FELINE Liquid Diet
USE: A ready to feed diet designed to for the intermittent or

supplemental feeding of dogs and cats.
DOSE: Cat: may be given orally or by tube feeding
FORMULATION: 8 fl oz (237 1111) can, provides 1.0 kcal/mL Shake

well before opening can. Once opened store in
refrigerator, discard after 5 days.
Enteral Nutrition VIVONEX PLUS
USE: 100% elemental high nitrogen diet for oral or tube feeding
(human product).
DOSE: May be given orally Of by tube feeding.
FORMULATION: Each packet of unflavored powder provides 300

ml; providing 1 calorie per 1111 (300 calories per
packet), distributed as 13.5 g (18%) protein
amino acids), 57.0 g (76%) carbohydrate, and 2 . 0
- 81 -
University of Florida .......... " .. " ................. " ..... Veterinary Medical Center
g (6%) fat. To prepare formula: add 250 ml of

warm water to 16 ounce container, add 1 packet,
cover and shake for 20 seconds. May be
blenderized if desired.
NOTE: After mixing, the fonnula may be left at room temperature for
up to 8 hours, or refrigerated for up to 48 hours.
Ephedrine Sulfate
USE: Sympathomimetic which stimulates both alpha and beta

receptors having cardiovascular and bronchial muscle effects
FORMULATION: 50 mg/ml for injection in 1 ml ampules
NOTE: HUMAN PRODUCT
Epinephrine HCI Adrenalin Chloride
USE: Emergency management of anaphylaxis and in cardiac

resuscitation
DOSE: Dog, Cat: 0.05 to 0.5 mg. May be given SQ, IM, IV, intra-
cardiac and intra-tracheal
Low Dose CPR: 0.01 mg/kg
Horse: 0.01 to 0.02 ml/kg SQ, 1M using 1:1000
Foal resnscitation:0.01 mg/kg IV, 1M, SQ; 0.1 mg/kg
endotracheal
Bovine: 0.02 to 0.03 mg/kg SQ, 1M, IV
FORMULA TION: 1 mg/1 ml ampule; 1 mg/ml in 30 ml vial.

[1 mg/ml = 1:1000J
NOTE:
1. Light sensitive and air sensitive.
2. Do not use if solution is discolored.
- 82 -
3. Contraindicated in epinephrine hypersensitivity, narrow angle

glaucoma, non-anaphylactic shock, and general anesthesia with
halogenated hydrocarbons.
4. Toxicities include cardiac arrhythmias and excessively elevated
blood pressure.
Epoetin Alpha PROCRIT-2
USE: Treatment of anemia of chronic renal failure
DOSE: Dog: 150 u/kg 3 times a week

Cat: 100 u/kg 2 to 3 times a week, maintain on one treatment
per week.
FORMULATION: 2,000 unitsll ml vial
NOTE:
1. HUMAN PRODUCT
2. Stored in refrigerator
3. Expensive
EQUALIZER
USE: Carpet stain and odor eliminator
FORMULATION: Contains 2-Butoxyethanol, Isopropyl alcohol in a

spray can, 14 oz
Ervthromycin
USE: Macrolide antibiotic, may be bactericidal or bacteriostatic

depending on concentration of drug
DOSE: Dog, Cat: 8.8 to 17.6 mg/kg PO TID with a small amount of
food
Foals: For Rhodococcus cqui pneumonia: 37.5 mg/kg PO
BID, uSlIally given in combination with rifampin.
- 83 -
Horse: To enhance gut motility: Using lactobionate: 0.1

mg/kg per hour IV. DO NOT administer IV push.
FORMULATION: 500 mg vial (as lactobionate) - mix with 10ml

sterile water, preservative-free (other diluents will
cause ppt); store in refrigerator, this concentrate is
stable for 14 days. To dilute further for infusion to
1 mg/ml or 5 mg/ml, use saline, LRS or
NormosolR (other diluents may be used but
require buffering - see insert); this diluted solution
is only stable for 8 hours.
NOTE:
I. HUMAN PRODUCT.
2. Drug of choice for Rhodococcus infections\
3. Use of erythromycin is a risk factor for clostridial enterocolitis
in horses .. .it should not be given to adults.
SIDE EFFECTS: 70% of dogs at VMTH vomited stearate the first time it
was given, generally tolerate drug after 2nd or 3rd
administration with food.
DRUG INTERACTIONS: Erythromycin can reduce serum clearance of

theophylline in man. Serum digoxin levels
may increase when drugs used together.
Check for other interactions.
Esmolol
USE: A beta-adrenergic receptor blocking agent. Esmolol is cardio-

sclective and preferentially inhibits BJ receptors. For supra-
ventricular tachycardia, and as a negative inotropic agent.
DOSE: Dog, Cat: 50 to 200 mcg per kg IV over I minute (some

references dose up to 500 mcg per kg , followed by
constant rate infusion of 100 mcg per kg per minute
if necessary.
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FORMULATION: 10 mg/ml in 10 ml single dose vial (preservative

free)
NOTE: HUMAN PRODUCT
Essential Fatty Acid Shampoo
USE: A pH balanced shampoo and conditioner formulated to enhance

dermal renourishment and control odor.
DOSE: For use in dogs and cats of any age. Shake well. Thoroughly
wet animal's coat. Lather. Allow lather to stand for 5 to 10
minutes. Rinse well.
FORMULATION: 16 oz. bottle contains ammonium lauryl sulfate,

lauramide DEA, methylchloroisthiazolinone, sun
ripened raspberry infusion, borage oil.
Ethiodized Oil ETHIODOL
USE: Ethidized oil (also known as Iodised oil) is an iodine addition

product of the ethyl esters of the fatty acids obtained from poppy-
seed oil. It contains about 37% (475mg/ml) of iodine, used for
interventional radiology procedures.
DOSE: Dog, Cat: Up to 3 mllkg MAX
FORMULATION: 37% (47Smg/ml) of iodine in IOml ampules
NOTE: Because of its solvent action on polystyrene, iodised oil

injection should not be given in syringes made with
polystyrene
Ethyl Lactate 10% ETIDERM Shampoo
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University of Florida ......................... " .. " ......... Veterinary Medical Center
USE: An antiseptic, keratoplastic shampoo for dogs and cats of any

age. An alternative shampoo for dogs that develop reactions to
other antibacterial shampoos.
FORMULA TTON: 8 oz bottle; gallon available as special order.
Ethylenediamine Dihydroiodide 3.65% in Dextrose
USE: Iodine feed supplement
FORMULATION: Powder available in a 1 pound pack:

1) Organic Iodine Dextrose - SPECIAL ORDER
Etodolac ETOGESIC
lJSE: A non-steroidal, anti-inl1ammatory agent (NSATD) with greater

selectivity for COX II inhibition than COX I (in vitro). For use
in dogs with degenerative joint disease, spinal arthritis, post-
operative analgesia particularly in orthopedic cases
DOSE: Dog: 10 - 15 mg/kg PO q24h
FORMULATION: 150 mg and 300 mg scored round tablet
NOTE: Owners should be advised to watch for signs of intolerance of

the medication: inappetence, vomiting, diarrhea, melena,
PU/PD, jaundice, lethargy, ataxia, seizure or behavior changes.
Aspirin containing products &/or other NSAIDS should not be
used while treating with etodolac.
USE: A non-barbiturate hypnotic with no analgesic activity, used for

anesthesia induction in patients in shock and with
cardiovascular disease.
DOSE: 0.3 mg/kg IV
- 86
University of Florida ....... " ........................ " .. ". Veterinary Medical Center
FOR1\1ULATION: 2 mg/ml in 10 ml vials.
NOTE: HUMAN PRODUCT
Famotidine PEPCID, PEPCID AC, generics
USE: An H2 receptor antagonist, uscd for the treatment and

prophylaxis of gastric, and duodenal ulcers, uremic gastritis,
stress induced gastritis, esophagitis, duodenal gastric reflux and
esophageal reflux.
DOSE: Dog, Cat: 0.5 to 1 mg/kg PO or IV ql2 to 24h

Cat: 0.5 mg/kg slow IV ovcr a minimum of 10 minutes
q 12h (watch for hemolysis as complication).
FORMULATION: 10 mg/ml for injection (20 ml multi-dose vial in

refrigerator); 10 mg tablet
NOTE:
1. A vailable aTe in 10 mg and 20 mg strength.
2. Famotidine does not appear to inhibit the hepatic cytochrome
PASO enzyme systems therefore, dmg interactions are reduced
(for other dmgs metabolized by the P-450 system).
Fat Emulsion INTRALlPlD 20%
USE: A source of calories and essential fatty acids for patients

requiring parenteral nutrition for extended periods
DOSE: Amount given should not exceed 50% oflhe calculated non-
protein calories/day; should not be given when serum
triglyccrides exceed 300 mg/d. For foals, refer to "Equine
Clinical Neonatology" by Koterba, et al.
See TPN formulas in Appendix
87 -
FORMULATION: As 20% emulsion - 250 ml; 260 mOsmollliter of

emulsion; emulsified fat particles of 0.5 micron
size; 2 kcallml
NOTE:
1. HUMAN PRODUCT
2. Do not use if separation of the emulsion can be visibly
identified by yellowish streaks or accumulation of yellowish
droplets in the admixed emulsion.
Fatty Acids Dietary Supplement OMEGA-3 EPA, MARINE LIPID

CONCENTRATE, CATALYST 3 MAXIMUM LIQUID
USE: Dietary supplement for the skin, used for anti-inflammatory

activity
DOSE: 1 capsule per 20 lb body weight daily.

0-60 lbs: One pump daily (on food)
60-100 lbs: Two pumps daily (on food)
> 100 lbs: Three pumps daily (on food)
FORMULATION: Each oil filled capsule contains: eicosapentaenoic

acid (EPA) 360 mg, docosahexaenoic acid (DHA)
240 mg, E (d-alpha tocopherol) 5 IV.
Per 2 pumps: EPA 540 mg, DHA 360 mg, Vitamin
E 8 IV; Vitamin A 400 IV; Vitamin D 100 IV. 237
ml bottle with pump.
NOTE: 1. STORE IN A COOL, DRY PLACE.

2. Do not use with lAMS Therapeutic diets because these diets
already contain fatty acids.
Fenbendazole PANACUR, PANACUR C
DOSE: Dog: 50 mg/kg PO daily for 3 days, repeat in 3 months for

whipwonns
Bovine: 5 mg/kg to 7.5 mg/kg orally 10 mg/kg PO for arrested
O. ostertagia larvae
- 88 -
Horse: 5 mg/kg orally; 10 mg/kg for ascarids; 10 mg/kg PO

for 5 days or 50 mg/kg PO for 3 days or 60 mg/lcg PO
once for mesenteric strongyles; 10 mg/kg PO for 5
consecutive days for larval cyathastomiasis.
Sheep: (not approved) 5 mg/kg orally
Goats: (not approved) 10 mg/kg PO as paste or drench
Swine: (not approved) 3 mg/kg daily in feed for 3 days; no
withdrawal time
Psittacines, Raptors: 25 to 50 mg/kg PO TID for 3 to 5 days
Repti.les: Nematodes: 50 to 100 mg/lcg, repeat in 2 weeks
FORMULATION: 100 mg/ml oral suspension; Power Pack Pastc

10% (5 x 57 g tubes), may purchase by the tube;
c,ranu es f or dogs order by tle pack et:

Dog Weight Packet Size
10 pounds 1 gram
20 pounds 2 gram
30 pounds I gram + 2 gram
40 pounds 4 gram
50 pounds 1 gram + 4 gram
60 pounds 2 gram + 4 gram
80 pounds Two 4 gram
Over 80 pounds Use combinations to obtain
recommended daily dose. ------~ ...
NOTE: For non-lactating dairy cattle only; 8 day slaughter withdrawal.
Fentanyl
USE: A narcotic analgesic used as a supplement in general or regional

anesthesia
DOSE: Dog: 1 to 10 mcg/kg IV to effect

Cat: 1 to 5 mcg/kg IV to effect
Horse: 1 to 2 mcg/kg IV (Valverde)
- 89 -
University of Florida ................. " ..................... Veterinary Medical Center
Dosing guidelines for trans dermal patch:
Cat 1.25mg or 2.5mg patch
Dog < 10 kg 1.25mg or 2.5mg patch

Dog 10 kg ~ 20 kg 5.0 mg patch --
Dog 20 kg - 30 kg 7.5 mg patch
Dog > 30kg 10 mg patch
Horse: 10 mg patch per 150 kg body weight
FORMULATION: 50 mcg/ml preservative-free solution, 5ml & 10 ml

vials; 1.25 mg, 2.5 mg, 5 mg, 7.5 mg and 10 mg
patches
NOTE:
1. HUMAN PRODUCT, controlled substance cn.
2. Atropine should be concurrently administered with injection.
3. A handout for clients is available for patients leaving the
hospital with a patch in place - see appendix.
4. When using the patch - be sure to REMOVE the clear backing
before applying the patch.
5. Retum patches to pharmacy for disposaL
6. Allow approximately 12-14h after application to reach adequate
serum levels; cats may be 6 hours.
7. Use generic patch by Sandoz other brand of generic has
sticking problems.
8. DO NOT cut patches. Do not cut part of the backing use
appropriate patch size .- cutting the backing may alter thc rate of
delivery and result in toxicity.
Ferrous sulfate
USE: To treat iron deficiency; chronic blood loss (as in blood donors)
- 90 -
DOSE: For maximum blood regeneration: up to 5 mg/kg/dayof

elemental iron or 25 mg/kg/day offerrous sulfate (1 mg
iron/kg/% increase in PCV)
NOTE: Problems with gastric irritation are probably exaggerated.

Continue for 6 months to replace storage iron. Equivalent Pet-
Tinic dose = 0.3 ml/kg/day
Ferrous sulfate is 20% elemental iron;

324 mg ferrous sulfate = 65 mg elemental iron
Filgrastim (rhG-CSF) NEUPOGEN
USE: Granulocyte colony stimulating factor, indicated for severe

neutropenia in chemotherapy patients
DOSE: Dog, Cat: 5 mcg/kg Q24H SQ
FORMULATION: 300 mcg/l ml vial- not stocked in pharmacy.

SPECIAL ORDER ONLY.
Fiptonil FRONTLINE SPRAY, FRONTLINE PLUS
USE: For dogs, cats, puppies and kittens older than 8 weeks, for the
control of fleas and ticks
DOSE: Spray at a rate of 1 to 2 pumps per pound. Apply FRONTLINE

PLUS directly on the skin between the shoulder blades. Apply
either product every 30 days for control of ticks and every I to 3
months for control of fleas.
FORMULATION: Spray is fipronil 0.29% in 250 ml bottle

(approx.160 pumps per bottle) and 500 ml bottle;
FRONTLINE PLUS is fiproniI9.8% +
methoprene, in packs of 3 pipettes.
- 91 -
All Cats (8 weeks and older): 0.5 ml pipettes

Dogs up to 22 pounds - 0.67 m! pipettes
Dogs 23 to 44 pounds - 1.34 ml pipettes
NOTE:
l. Wear rubber gloves when applying.
2. Dogs greater than 132 pounds, use appropriate combination.
3. Wait 2 days after shampooing to apply and wait 2 days after
application before shampooing.
4. Sunlight, rain and non-medicated shampoos do not significantly
shorten duration of protection.
5. Do NOT use in bunnies.
Firocoxib PREVICOX
USE: A non-steroidal anti-inflammatory drug of the coxib class;

indicated for the control of pain and inflammation associated
with osteoarthritis in dogs.
DOSE: Dogs greater than 7 months old: 5 mg/kg PO Q24H. Pcr

manufacturer _. may be administered with or without food.
FORMULA nON: 57 mg and 227 mg, round, scored chewable tablet.

227mg tablets available in a sample pack of 10
tablets. Refills will not be recognized for sample
packs.
NOTE:
1. The safe use offirocoxib in pregnant, lactating or breeding dogs
has not been evaluated.
2. This product cannot be accurately dosed in dogs < 3.2kg of
body weight.
3. Exceeding dose of 5mg/kg has been associated with serious
adverse reactions, including death.
4, Do not use in dogs taking aspirin containing products, other
NSAIDS, or corticosteroids.
·,92
Florfenicol NUFLOR
USE: A synthetic, broad spectrum antibiotic for treatment of

susceptible bacterial infections in cattle, sheep and goats.
Approved for 1M, SQ use in cattle only. Primarily bacteriostatic.
DOSE: Cattle, Sheep, Goats: 20 mglkg 1M q48h; or 40 mglkg SQ as

single dose
FORMULATION: 300 mg/ml, in 100ml MDV, may order by the ml.
NOTE:
1. Do not administer more than 10 ml per site; injections should be
given only in the neck.
2. Do not use in calves intended for veal.
3. Do not use in female dairy cattle 20 months of age or older.
4. Animals intended for human consumption must not be
slaughtered with 28 days oflast 1M injection or 38 days oflast
subcutaneous injection.
Fluconazole
USE: A synthetic triazole antifungal
DOSE: Horse: 5 mg/kg PO q24h

Foal: Candida, 4 mglkg PO q24h
Fludrocortisone Acetate
USE: A mineralocorticoid used to treat chronic adrenocortical

insufficiency; also has glucocorticoid activity
DOSE: Dog: 0.1 mg/5 kg body weight per day or 0.1 mg/lO pounds per
day or 0.05 mglkg per day divided every 12 hours.
Monitor serum sodium and potassium levels.
- 93 -
University of Florida ......................................... Veterinary Medical Center
Cat: 0.1 mg PO per day to start, then titrate to effect
FORMULATION: 0.1 mg tablet
Flumazenil ROMAZICON
USE: Competitive inhibitor at the benzodiazepine recognition site on

the GABA/benzodiazepine receptor complex.
FORMULATION: O.lmg/ml solution for injection in 5 m1 MDV
F'lunixin Meglumine BANAMINE, FLIJNIXAMINE
USE: Non-steroidal, anti-inflammatory, analgesic approved for usc in

inflammation and pain in horses
DOSE: Dog: 0.3 mg/kg 1M daily for not more than 3 days
Horse: 1 mg/kg IV or 1M BID treatment should not exceed 5
days; 0.5 mg per pound by mouth once a day up to 5
days.
Al1Ji:~llQgtQ:;{ill.dose: 0.25 mgfkg IV or 1M TID
FORMULA nON: 50 mg/ml solution for injection; 1500 mg pastc-

each calibration on syringe doses 250 pounds of
body weight.
NOTE: May cause gastric ulceration - dogs arc very sensitive to this
effect; use great caution if corticosteroids must also be used.
FluocinoJone acetonide, UMBO SYNOTIC
USE: Anti-inflammatory used in treatment of otitis externa.
DOSE: Dogs: 4 to 6 drops in ear BID for a maximum of 14 days.
- 94 -
FORMULATION: Each ml contains 0.01% fluocinolone acetonide

60% DMSO in propylene glycol and citric acid; in
8 ml dropper bottle
NOTE: Wear gloves when using this product.
Fluorescein Sodium
USE: Ophthalmic diagnostic aid
FORMULATION: Strips for ophthalmic use from Central Stores;

10% injection in 5 ml amp - special order only
Fluorouracil
DOSE: Dog: 150 mg/m2 IV or intracavitary q7d

Cat: Severe neurotoxicity precludes usage
FORMULATION: 500 mg per 10 ml vial.
NOTE: HUMAN PRODUCT
CONTRAINDICATIONS: Poor nutritional status. Depressed bone

marrow function. Discontinue if stomatitis
andlor esophago- pharyngitis appear, if
WBC < 3,500/111 or if platelets < 100,000/111.
TOXICITIES: Cerebellar ataxia.
COMMENTS: May cause hypoalbuminemia secondary to fluorouracil

induced protein malabsorption. May also cause
increased serum alkaline phosphatase, alanine
aminotransferase, aspartate aminotransferase and lactic
dehydrogenase activities as well as hyperbilirubinemia.
Capable of crossing blood brain barrier.
- 95 -
Fluoxetioe RECONCILE
USE: A selective serotonin reuptake inhibitor (SSRI), approved for

the treatment of canine separation anxiety in conjunction with a
behavior modification plan.
DOSE: Dog: 1 - 2 mg/kg PO QD, with or without food.
FORMULATION: Chewable, flavored tablet in Smg, 16mg, 32mg,

64mg
NOTE:
1. The efficacy and safety for long-term use (greater than S weeks)
has not been evaluated.
2. To discontinue therapy, it is not necessary to taper or reduce
doses because of the long half-life of the drug (Tl/2 ranges from
3 to 12.9 hours, active metabolite (norfluoxetine) has Tl/2 from
33 to 64 hours).
3. 3. Allow a six week wash out period after stopping fluoxetine
before beginning any drug that may interact adversely with
fluoxetine or its active metabolite norfluoxetine.
4. 4. If a dose is missed - the next dose should be on schedule - do
not increase or double the dose.
5. Contraindicated for use in dogs with epilepsy or in conjunction
with drugs that lower seizure threshold.
6. RECONCILE is not recommended for the treatment of
aggression.
7. Studies have not been done to determine the effects of
RECONCILE in breeding, pregnant or lactating dogs, and in
patients less than 6 months of age.
S. Do NOT use in combination with MAOI (selegiline, amitraz) or
within a minimum of 14 days of discontinuing a MAOI.
9. Metabolized in the liver by cytochrome P-450 enzyme system-
watch for drug interactions .
.Flurbiprofeo 0.03% Ophth Solo
- 96-
Univcrsity of Florida ........................................ Vcterinary Medical Center
USE: A topical NSAID for use in inflammation in the eye, for dogs,
cats, and horses.
DOSE: Use every 8 to 12 hours
FORMULATION: 2.5 ml dropper tip bottle
Fluticasone Propionate Inhaler FLOVENT HFA
USE: A synthetic, tritluorinated glucocorticoid used in the treatment

of inflammatory airway disease and chronic obstructive
pulmonary disease (COPD)
DOSE: Horse (adult): 220 mcg per puff, 9 puffs BID by mask for 14
days for non-septic airway inflammation.
FORMULATION: 12 g canister containing 120 actuations of220 mcg

per actuation - SPECIAL ORDER
Fomepizole ANTIZOLE-VET, 4-methylpyrazole
USE: An inhibitor of alcohol dehydrogenase, used for the trcatmcnt of

ethylene glycol poisoning in dogs only.
DOSE: Dog: 20 mg/kg IV initially, then 15 mg/kg at 12 and 24 hours,

and 5 mg/kg at 36 hours after the first dose.
FORMULA TION: As a kit containing one vial of 1.5 g Antizole-Vet

and one vial of diluent (30 ml 0.9% saline)
NOTE: Storc thc rcconstitutcd vial at room temperature; discard aftcr 72

hours.
:Furosemide SALIX, generic
USE: Loop diurctic, pulmonary vascular dilator, weak carbonic

anhydrase inhibitor. Used as a diuretic for the correction of
- 97 -
University of Florida ........................................ Veterinary Medical Ccnter
hypercalcemia, treatment of acute renal failure and as

antihypeliensive agent.
DOSE: EllimQI!i.u:yedema - acute: Dog: 2 to 8 mg/kg IV or IM pm (ql-

8h), Cat: 1 to 4 1l1g/kg IV or 1M pm
Pulmonary edema - chronic: Dog, Cat: 2 to 4 mg/kg PO q8h to
q12h
Hypercalcemia: 5 mg/kg IV bolus; then 5 mg/kg/h infusion
(maintain full hydration throughout treatment)
Acute renal failure with oliguria: Rehydrate first. then give 2
lng/kg IV. rf no response in I hour give 4 mg/kg IV. If no
response in I hour give 6 mg/kg IV (may be used in conjunction
with IV dopamine at 3 meg/kg/min).
Horse: I mg/kg IV or IM qI2 to 24h

For epistaxis prevcntion prior to racing: 0.5 mg/kg 4 hours prior
to racing
Bovine: I mg/kg IV, 1M qI2 to 24h

DO NOT ADMINISTER TO CATTLE AFTER 48 HOURS
POST-PARTURITION.
FORi\;fULA nON: 12.5 mg tablet, 50 mg tablet, 10 mg/ml oral symp

in 60 1111 bottle with calibrated dropper - expires 60
days after opening bottle; 50 mg/ml injection - do
not use if solution for injection is darker than light
beer colored.
NOTE:
1. Will induce extreme ECF volume depletion and Na+, Cl-Ca++,
and K+ imbalance. Anorectic patients should be supplemcnted
with potassium if hypokalemia is likely. Ototoxicity may occur.
Enhances the nephrotoxic effect of gentamicin.
48 hour milk withdrawal; 48 hour slaughter withdrawal
Gabapentill
- 98 -
USE: Indicated for treatment of refractory or partial seizure,

neuropathic pain and nerve root pain. Also useful for IVDD,
spinal tumors.
DOSE: Dog, Cat: 10 to 30mg/kg PO q8h
FORMULATION: 100mg, 300mg capsule
Note: HUMAN PRODUCT
Gentamicin
USE: Broad-spectrum aminoglycoside antibiotic. Binds to 30s

ribosome of bacteria thereby blocking protein synthesis. Most
effective against gram negative bacteria including Pseudomonas
sp. Most Staphylococcus sp. are susceptible but Streptococcus
sp. can be resistant. Not effective against many anaerobes.
DOSE: Dog, cat: 1.5 mg/kg IM, SC or IV q8h

Horses: 3.3 mg/kg IV or IM ql2h, or 6.6 mg/kg IV or 1M q24h
Horses: Intrauterine: 2.0 to 2.5 grams in 200 to 500 ml sterile
saline per day for 3 to 5 days during estrus; via uterine infusion.
Foal7 mg/kg IV or IM q24h
Alligator: 1.75 mg/kg q72 to 96h
Aquatic Turtles: 6 to 10 mg/kg q48 to 120h
Snakes: 2.5 mg/kg q72h
Pigeons, quails: 10 mg/kg IM, SQ QID
Cranes, pheasants: 5 mg/kg 1M, SQ TID
Psittacines: 2 to 3 mg/kg 1M, SQ BID to TID
Red-tailed Hawk, Great Horned Owl, Golden Eagle: 2.5
mg/kg 1M, SQ TID
FORMULA TION: 100 mg/ml (veterinary - approved for intrauterine

use in horses)
NOTE:
1. Aminoglycoside - nephrotoxic and ototoxic.
2. Nephrotoxicity: Monitor urine for cylindruria and a drop in
urine SG. Toxicity can be expected to develop after 10 to 14
- 99 -
days of treatment. Toxicity is enhanced by dehydration,

concurrent furosemide treatment, concun'ent administration of
other nephrotoxic drugs.
3. Depresses equine gut motility.
4. Neuromuscular blockage: Rapid IV administration can induce
respiratory arrest Synergistic with other neuromuscular
blocking agents.
5. NOT FOR USE fN ANIMALS fNTENDED FOR FOOD.
6. Wildlife: High doses may produce transient or prolonged
polyuria/polydypsia. Concomitant suppleulental fluid therapy
and oral electrolytes may be indicated.
Gentamicin Sulfate 0.3% Ophthalmic
USE: A bactericidal aminoglycoside antibiotic used in the treatment

of conjunctivitis.
DOSE: Dog. Cat: usc in affected eye q4 to 8h
FORMULATION: Ophthalmic solution, 5 ml with droppcr tip
Gentamicin sulfate 0.3%, Betamethasone 0.1 % Otic Solution
USE: A b<.!ctericidal antibiutic cumbincd with a synthctic

corticosteroid; used in the treatment of acute and chronic canine
otitis cxtcma and canine and fcline supcrficial infected lesions.
DOSE: Otic: 3 to 8 drops into car canal q8 to 12h for I to 2 weeks
FORMULA nON: 7.5 ml with dropper tip
Glucagon
USE: To treat hypoglyccmia when oral sugar solution is

contraindicated.
100
DOSE: Dog: Hypoglycemia: 0.03 mg/kg IV or 1M; duration is usually

for 30 minutes
FORMULATION: I unit (1 mg) per vial, lyophilized
NOTE:
1. HUMAN PRODUCT
2. Should be used immediately after reconstitution; but may be
refrigerated for 48 hours. Solutions should be clear and of
water-like consistency.
Glucosamine HCI, Sodium Chondroitin Sulfate, Manganese

Ascorbate COSEQUIN, COSEQUIN DS
USE: A nutraceutical which provides components necessary for the

synthesis of synovial fluid, and the complete cartilage matrix,
for use in degenerative joint disease.
DOSE: Dogs, and Cats: Dose per manufacturer recommendation for an

initial period of 4 to 6 weeks, followed by a gradual reduction in
dosage to a maintenance dose.
FORMULATION: Cosequin (regular strength) for cats and dogs

under 25 pounds; Cosequin DS (double strength)
for dogs over 25 pounds.
Glycerin
USE: Emollient, systemic osmotic agent.
FORMULATION: 82.5% suppositories; liquid by the ml
Glycopyrrolate ROBINUL-V, generic
USE: An anticholinergic used pre-op to decrease secretions and block

vagal inhibitory reflexes.
- 101 -
DOSE: Dog: (Ull mg/kg 1M or SQ
FORc\;[ULATION: 0.2 mg/ml injection in 20 ml vial
Gonadorelin CYSTORELIN
USE: For the treatment of cystic follicles in cows
DOSE: Dog: 2 mcg/kg 1M only

Bovine: 100 mcg IV or 1M
FORMULATION: 50 mcg/ml in 10 m] vial
NOTE: Store under refrigeration.
Guaifcnesin
USE: Orally as an expectorant; parenterally as a skeletal muscle

relaxant.
DOSE: Horse, Bovine: 3 to 4 g/50 kg IV as skeletal muscle relaxant. A

concentration of 5% will cause hemolysis in
bovines.
FORMULA nON: **Currently unavailable from manufacturer. **

Ready mixed 50 grams in 32 oz bottle, in dextrose
50 mg/mI, propylene glycol 20 mg/ml,
dimethylacetamide 50 mg/ml
Hemoglobin Glutamer 200 (bovine) OXYGLOBIN
USE: Treatment of anemia in dogs by increasing systemic oxygen

content and improving clinical signs for at least 24 how's
regardless of the cause of the anemia
DOSE: Dogs: A one time dose of 10 to 30 mllkg of body weight, IV
- 102-
at a rate of up to 10 ml/kg/hr (greater than 10 ml/kg/hr

may lead to circulatory overload)
Foal: 4 bags per foal
FORMULATION: 125 ml single use bag
NOTE:
1. Store at room temperature or under refrigeration ... do not freeze.
2. Once the overwrap has been removed from the bag, the bag
must be used within 24 hours.
3. Dispose of any remaining as veterinary medical waste.
4. PVC and RBC are not accurate for 24 hours after
administration.
5. A transient discoloration of mucous membranes, sclera, urine
and skin may be observed.
Heparin Sodium Injection
USE: Inhibits reactions which lead to the clotting of blood and the
formation of fibrin clots
DOSE: For IV, SQ use
FORMULATION: 1000 u/ml in 10 ml vials, and 10,000 u/ml in 5 ml

vials.
Hetastarch 6% in 0.9% Sodium Chloride
USE: For plasma volume expansion in the treatment of shock
DOSE: Dog, Cat: 10 to 20 ml/kg/day

Horse: 10 mVkg IV as slow bolus
FORMULA TION: 500 ml bag
Hyaluronate Sodium HYLARTIN V, LEGEND
- 103 -
USE: Equine osteoarthritis associated with non-infectious synovitis.

Also used to reinflate anterior chamber in dogs, cats, and horses.
DOSE: Equine: Intra-articular HylartinV: Carpal, fetlock joints: 2 ml;

Hock and stifle joints: 4 ml
Intravenous LEGEND: 4 ml slowly in jugular vein, may repeat
for total of 3 treatments (see manufacturer insert for IA
administration)
FORMULATION: HYLARTIN-V: 2 ml pre-filled syringe 10 mg/ml,

MW 3,000,000D; LEGEND: 10 mg/ml, 4 ml vial
NOTE: Store HYLARTIN V at 2° to 8°C, protect from freezing, protect

from light; store LEGEND at room temperature. Discard any
unused portion of the drug.
Hydralazine
USE: Arterial vasodilator useful in the treatment of CHF due to severe

mitral insufficiency that is refractory to conventional therapy;
also used for acute hypertensive crisis.
DOSE: Dog: 0.5 to 3.0 mg/kg PO q8-12h, 0.5 to 3.0 mg/kg IV or SQ

q12h or as CRI @ 1.5 to 5.0 mcg/kg/min, after a loading
dose of 0.1 mg/kg
Cat: 2.5mg per cat SQ
FORMULATION: 10 mg tablets; 20 mg/ml in 1 ml vial
Hydrocodone Bitartrate TUSSIGON, HYCODAN, generic
USE: Opiate antitussive
DOSE: Dog: 0.22 mg/kg PO BID to QID
FORMULATION: Hydrocodone bitartrate 5 mg per 5 ml syrup, or

hydrocodone bitartrate 5 mg per tablet, both
- 104-
formulations also contain homatropine

methylbromide
NOTE:
1. HUMAN PRODUCT, Schedule III controlled substance
2. Can cause behavioral abnormalities
Hydrocortisone 1 %
USE: For the treatment of inflammatory and pruritic skin disorders
FORMULATION: 1 ounce tube cream
Hydrocortisone 1% Conditioner ResiCORT Conditioner
USE: A leave on conditioner for dogs and cats; formulated to relieve

pruritus and inflammation associated with corticosteroid
responsive dermatoses.
DOSE: Apply after shampooing or wetting the coat; may also be used in
localized areas between shampoos.
FORMULATION: 8 oz bottle
NOTE:
1. Shake well before using.
2. Wear rubber gloves &/or wash hands and exposed skin after
applying to animal.
Hydrocortisone sod. succinate injection SOLU-CORTEF
USE: A glucocorticoid, with salt-retaining properties and potent anti-

inflammatory effects in disorders of many organ systems.
DOSE: Horse: For septic shock, ARDS: 1 mg/kg IV q6h (given with
fludrocortisone 0.5 mcg/kg PO q24h)
- 105-
FORMULATION: 250 mg vial, single dose vials - discard any

remaining after 72 hours.
Hydrogen Peroxide 3%
DOSE: SA and LA: Apply topically as needed (3%); may dilute 1 part
hydrogen peroxide to 3 parts water
FORMULATION: Available in 16 oz bottles
Hydromorphone
USE: A semi-synthetic morphine analog, providing analgesia similar

to morphine and oxymorphone, less expensive than
oxymorphone. Hydromorphone may infrequently cause mild
histamine release in dog, cat after IV injection.
DOSE: Dog: 0.2 mg/kg IM, IV, SQ Q2 to 4 hours
FORMULATION: 2 mg/ml solution for injection in 1 ml vial; 20 ml

MDV
NOTE:
l. C-II controlled substance.
2. May cause hyperthermia in cats.
Hydroxyzine
USE: Piperazine antihistamine of choice in many dermatologic

conditions
DOSE: Dog: 2.2 mg/kg PO BID or TID

Horse: 0.5 to I mg/kg PO BID
Avian: Feather chewing skin disease - 2 mg/kg PO TID - QID
FORMULATION: 25 mg, and 50 mg (pamoate) capsule; 2 mg/ml oral

syrup (with alcohol 0.5%).
- 106-
NOTE:
I. HUMAN PRODUCT
2. May cause sedation, antihistamines have anticholinergic actions
(dry mouth, headache, dysuria) which may be prolonged by
MAO inhibitors.
Contraindicated for use in conjunction with MIT ABAN dip.
Hypo-Allergenic Shampoo HYL YTefa CREME RINSE
USE: Hypo-allergenic, moisturizing creme rinse for dogs and cats to

be used after shampooing with drying medicated shampoo.
DOSE: Dog and cat: Use atter medicated shampooing. Apply evenly
and thoroughly into hair coat, allow to sit for 10 minutes, rinse
well. May use as otten as necessary.
FORMULA TION: 8 oz. bottle contains emollients, emulsifiers, and

natural moisturizing factors.
Imidadoprid 9.1 % ADVANTAGE
USE: An insecticide for dogs ands cats used to kill adult Heas; acts by
binding to the insect's nicotinyl receptor sites on the post-
synaptic neuron.
DOSE: Dog and Cat: a topical solution applied to the skin between the
shoulder blades of dogs and at the base of the neck of cats;
applied approximately evelY 4 weeks.
FORMULATION: Available in packs of 4 tubes;
~-~
Cats Less than 9pounds 0.4 ml tubes
(----
, greater then 9 pounds 0.8 ml tubes
~l- 10 pounds and under 0.4 m} tubes
___ I IlJ:c.l20 pClUnds I ml tubes_
I 21 to 55 2<?unda 2.5 ml tubes
- 107 -
L _] 56 pOllnds and lI"-JILJ_-"..1_4_1_11_I_tll....;b__e-,-s---,

NOTE:
1. For use in puppies 7 weeks and older and kittens 8 weeks and
older.
2. Bathing and grooming my decrease duration of affect; re-apply
no more often than once per week.
3. Kills 98 to 100% of existing fleas in 24 hours; lasts up to 4
weeks in cats and at least 4 weeks in dogs.
4. Contains benzyl alcohol; may be washed off in case of adverse
reaction.
5. Bunnies (not FDA approved): Less than 5 lbs lise 0.2 ml (use
syringe); greater than 5 lbs use 0.4 tnl.
6. Ferrets (not FDA approved): use 0.2 ml (use syringe)
lmidacloprid 10% + Moxidectin 1 % ADVANTAGE MOL Tl for

CATS
USE: A topical insecticide for kittens and cats used to prevent

hcartworm disease (L3 & L41arvae); kill adult fleas (c. felis);
treat and control ear mite infestations (Otodectes cynotis), and
intestinal parasites (Ancylostoma tubaeforme, Toxocara cati);
also, used in treatment strategy of FAD.
DOSE: Cat: a topical solution applied to the skin at the base of the neck
of cats; applied approximately every 4 weeks.
FORMULATION: Available in packs of6 tubes:

Cats 5.1 to 9 pounds - 0.4 ml tubes
Cats 9.1 to 18 pounds - 0.8 1111 tubes
NOTE:
l. Cats should be dosed a 0.11111 Ikg.
2. Do not use in kittens less than 9 weeks old OR cats less than 2
pounds.
3. Small kitten/cat size currently not stocked.
4. SafCiy has not been established in breeding, pregnant, or
lactating cats.
108 -
University ofFlorida"",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Veterinary Medical Center
5, Children should not come in contact with the application site for
30 minutes after application,
6, A Iter application of product - wash hands thoroughly with soap
and water.
Imidacloprid 10% + Moxidectin 2.5% ADVANTAGE MULTI for

DOGS
USE: A topical solution for dogs used to prevent heartworm disease

(L3 & L4 larvae); kill adult fleas (C, feEs); treat and prevent
hookworms (Ancylostoma canium, Unicaria stenoeephala),
roundworms (Toxocara canis, Toxascaris Leonia), and
whipworms (Trichuris vulpis); treatment of ear mites, sarcoptic
mange, demodicosis; also, used in treatment strategy of FAD,
DOSE: Dog: Apply topical solution to the skin between the shoulder
blades every 4 weeks,
FORMULATION: Available in packs of 6 tubes:

Dogs 3 to 9 pounds - 0.4 ml tubes
Dogs 9.1 to 20 pounds - I ml tubes
Dogs 20,1 to 55 pounds - 2,5 ml tubes
Dogs over 55,[ to 88 pounds - 4 ml tubes
NOTE:
1. Do not use in puppies less than 7 weeks of age; or less than 3
pounds
2. Dogs should be heartworm tested prior to initiation of treatment
with this product. This product is not effective for microfilariae
clcarancc,
3. Do not use the canine product to treat cats,
4, Contains benzyl alcohol; may be washed otf in case of adverse
reaction,
5, After application of product - wash hands thoroughly with soap
and water.
6, For the first 30 minutes after application of product: Do not
allow dogs to lick treated areas, Do not allow children to come
in contact with application site for 2 hours after application,
- 109 -
University of Florida ,. ...................................... Veterinary Medical Center
7. Safety has not been established in breeding, prcgnant, or

lactating dogs
8. Shampooing 90 minutes after application does not reduce the
effectiveness of this prodnet in the prevention ofheartwonn
disease. Shampooing or swimming 4 days after application docs
not decrease effectiveness of this product in the treatment oftlea
infestations. Shampooing as often as once a week may reduce
the effectiveness of this product in the treatment of flea
infestations.
9. Use caution in avermeetin sensitive dogs.
Irnidacloprid 9.1 %, Perrnethrin 44% ADVANTIX
USE: Topical prevention and treatment ofticks, fleas and mosquitoes

for monthly application on dogs and puppies 7 weeks of age and
older.
DOSE: Dog: a topical solution applied to the skin between the shoulder
blades of dogs (and along the back oflarge dogs) approximately
every 4 weeks.
FORMULATION: Available in packs of4 tubes;

Dogs 10 pounus and under OA m! tubes
Dogs 11 to 20 pounds 1 ml tubes
Dogs 21 to 55 pounds 2.5 ml tubes
Dogs over 56 pounds 4 ml tubes
NOTE:
L For use in puppies 7 weeks and older.
2. DO NOT USE THIS PRODUCT ON CATS. Do not allow cats
to groom recently treated dogs.
3. 4 ml will cover up to 200 pound dog - per Baycr.
lrnidocarb dipropionate IMIZOL
USE: Indicated for the treatment of dogs with clinical of

babesiosis and/or demonstrated Babesia organisms in the blood.
- 110 -
DOSE: Dog: 6.6mg/kg 1M, SQ; repeat dose in 2 weeks.
FORMULATION: 120mg/ml, lOml multi-dose vial. SPECIAL

ORDER.
NOTE:
1. DO NOT administer IV
2. In the event of human exposure, call 800-228-5635 ext. 113 for
medical advice.
Imipenem-Cilastatin PRIMAXIN I.V.
USE: A potent, broad-spectrum antibacterial agent with bactericidal

activity, and a high degree of stability against beta-Iactamases
including certain gram-negative bacteria which show resistance
to most beta-Iactanl antibiotics.
DOSE: Dog, Cat: 3 to 5 mg/kg TID to QID, IV SLOW infusion

Horse: 5 to 15 mg/kg IV over 20 minutes, q6h
FORMULATION: Primaxin I.V. 250 provides 250 mg ofimipenem

and 250 mg of cilastatin. SPECIAL ORDER.
NOTE:
1. HUMAN PRODUCT. Expensive.
2. Solutions may be colorless to yellow.
3. When reconstituted per package insert directions, stability is 24
hours under refrigeration; solutions should not be frozen. To
reconstitute: add 10 ml of diluent, shake well, (this concentrate
is not for direct infusion), transfer the suspension into the
infusion solution container. Diluents include saline, D5W,
D5W with 0.45& saline, D5W with 0.15% K Cl. Per Trissel's
Handbook on Injectable Drugs lith ed, imipenem in saline to
2.5mg/ml results in 7% loss in 72 hrs @ 4°C (39°F); 5mg/ml in
saline results in 11 % loss in 72 hrs @ 4°C (39°F).
4. This antibiotic should not be used indiscriminately, to avoid
development of "super-bugs".
- 111 -
Imipramine
USE: A tricyclic antidepressant used to treat cataplexy and urinary

incontinence in dogs, and narcolepsy and ejaculatory
dysfi.mction in horses
DOSE: Refer to Vcterinary Drug Handbook, Don Plumb
NOTE: Special ordcr - chcck for availability.
Immune Globulin (Human)
CSE: An immune serum containing immune globulin form human

serum or plasma. Provides antibodies that bind and neutralize
pathogenic autoantibodies and immediate antibody levels against
bacterial, viral, parasitic, and mycoplasmic antigens.
FORMULATION: Vial size is variable, depending availability.
DOSE: Dogs, Cats: Initial dose 0.5 units/kg SQ QD. Best to give the
dose divided BID (i.e. start with O.25unitslkg SQ BID) and
increase to maintain blood glucose within acceptable range.
ProZinc and glargine not recommended for use in dogs.
Glargine initial dose in cats is 0.25 - 0.5 units/kg per day.
divided BID. Adjust dose after 5 to 7 days, then as needed.
Horses: Humulin is preferred insulin
Classification Type Onset" Peaka Durati(j,lliL_

Rapid Regular 0.5 - 1 hr 2-4 hr 6 - 8 hr
Intermediate NPH b, 1- 2 hr 6 - 8 hr 18 - 24 hI
VctsuIin 1 3 hr 4-11 hr 12 - 24 hr
Long ProZinc c • I 3 hr 4 --12 hr 8 -- 24 hr
Glargincd 2 4 hr 8 - 12 hr 20 - 30 hr
- 112 -
a = Onset, peak, and duration based on SQ injection. Longer duration

with renal and hepatic insufficiency.
b = Durations are derived from activity in humans, in the cat peak effect
can occur in 2 to 4 hours and duration can only last 12 hours, calling for
split dosage.
c = Approved for use in cats.
d = When switching from PZI to glargine, some animals will not be
covered for 24 hours, characterized by an early peak action with late AM
or early PM hypoglycemia and marked glycosuria detected on the
following morning, requires a split dosage regimen.
NOTE:
I. Regular insulin can be given SQ, 1M, IV. Preferred for the sick,
decompensated diabetic.
a. SO use for DKA in dogs and cats: May use SQ in
DKA if animal is minimally dehydrated (5 to 7%).
Begin with 0.5units/kg and titrate to effect Q6h.
b. IV CRI: Only for regular insulin. Initial dose is 0.1
unit/kg IV followed by O.lunit/kg/HOUR.
c. 1M: Dogs: 0.2units/kg 1M once, then 0.1 units/kg
one hour later, then titrate to response.
Cats: 1 unit per cat 1M once, then titrate hourly
according to response.
2. NPH, glargine (Lantus), PZI, Vetsulin, ProZinc must be given
SQ only.
3. Vetsulin is similar to Lente which is similar to NPH. All may be
used interchangeably.
4. Diluting insulin: Pharmacy stocks insulin diluent for Humulin N
and Humulin R. In an emergency where no diluent is available,
preservative-free nOlmal saline injection may be used. These
solutions should be used immediately as they are not stable, and
also have a lower pH which may result in stinging at injection
site. Do NOT dilute Glargine.
5. Can use insulin glargine in cats, use BID as you would PZI or
ProZinc.
6. Vetsulin is Pork-Lente U40; dose SQ BID.
7. PZI VET (PZI Insulin) U40 was discontinued by manufacturer
(Idexx) in 2008.
8. Use U-40 syringes to accurately measure U40 insulin dose.
- 113 -
9. Caution - Vetsulin works similarly to Lente and it has an early

peak action component from its amorphous insulin fraction.
Begin similarly to NPH (Humulin-N) at a starting does 01'0.5
units per kg per day divided and titrated to effect. Do not try to
give the entire dose in one injection due to potential for causing
hypoglycemia in many cats and dogs.
FORMULATION: 10 ml vial: Humulin R U-IOO, Humulin N U-lOO,

PZI pork (PZIVET) U-40 - until inventory IS
depleted, then switch to Vetsulin, ProZine
40unit!ml
U-IOO means 100 units of insulin per m1.

• USE A U-100 SYRINGE ONLY.
U-40 means 40 units of insulin per ml.
• USE A U-40 SYRINGE ONLY.
Iodine Tincture, strong
FORMULATION: Iodine 7%
Potassium Iodide 5%
Isopropyl alcohol 85% v/v
Iron dextran
USE: Injectable hematinic
DOSE: 0.02 ml!kg/% deficit in PCV.
Half as much again is needed to replace storage iron. To replace

10% deficit in 10 Ib pup would require 0.25 ml daily for 4 days.
Has induced sarcomas in lab animals. Can cause anaphylaxis
especially if given IV. Painful 1M. (Hill 1996)
FORMULA TION: 100 mg/ml elemental iron. 100 ml vial
- 114 -
University of Florida .................................. " .... Veterinary Medical Center
Isotlupredone acetate PreDEF 2X
USE: A fluorinated steroid for 1M or intra-synovial use. Also, an

ingredient in Pharyngeal Flush.
FORMULATION: 2 mg/ml suspension (SHAKE WELL) for injection
Isotlurane ISO FLO
USE: lnhalation anesthetic. Rapid induction and recovery MAC 1.5%,
Isoproterenol HCI ISUPREL
USE: 13 1 and 132 adrenergic agonist
DOSE: Dog, Cat: 0.4 mg in 250 ml Dextrose 5% Water, drip slowly

to effect.
Horse: 0.4 meg/kg by SLOW IV infusion - discontinue when
heart rate doubles.
Foal resnscitation:0.05 to 1.0 mcg/kg/min IV.
FORMULATION: 1 mg/5 m] ampule
NOTE: HUMAN PRODUCT
Isoxsun rine
USE: A vasodilator; used in treatment of navicular disease and acute

laminitis
DOSE: Horse: 0.6 mg/kg PO q12h for 30 days, then 0.6 mg/kg PO
daily for 30 days
FORMULATION: 20 mg tablel- SPECIAL ORDER
- 115 -
U ni versity of Flori da ........................................ Veterinary M edi cal Center
NOTE: HUMAN PRODUCT
ltraconazole SPORANOX, generic
USE: A synthetic triazole antifungal agent indicated for treatment of

susceptible fungal infections including blastomycosis and
histoplasmosis
DOSE: Dog: 5 mg/kg QD

Cat: Ringworm:, 10 mg/kg PO QD for up to 3 months.
Horse: 3 mg/kg PO BID for up to 2 months
FORMULATION: 100 mg capsules; oral solution 10 mg/m! - discard

contents 60 days after opening bottle.
NOTE:
1. To maximize absorption:
a. Capsules should be administered with food.
b. Oral solution should be administered on empty
stomach.
2. Oral solution should not be used interchangeably with capsules.
3. HUMAN PRODUCT. VERY EXPENSIVE.
4. Double check for dmg interactions.
5. May cause nausea and vomiting in cats.
6. Light sensitive.
lvermectin IVOMEC, EQVALAN, HEARTGARD, HEARTGARD-

PLUS, HEARTGARD For Cats, generics
USE: I. Healiwofm preventative

2. Microfilaricide (not FDA approved)
3. General anthelmintic in canines (not FDA approved)
4. Large animal anthelmintic
DOSE: Dog:
Heartworm preventive: 6 mcg/kg PO once monthly
Microfilaricide: 50 meg/kg once or twice, 14 days apart
Anthelminti«: 100 to 250 meg/kg as PO once
- 116 -
Demodex: 400 to 600 meg/kg PO QD (not FDA approved)

Side effects: Salivation, nausea, weakness. DO NOT USE IN
COLLIES.
Cat: Heartworm preventive: 24 meg/kg PO once monthly
Horse: 0.3 mg/kg PO as paste or drench
Bovine: 0.2 mg/kg SQ - DO NOT USE 1M. For non- lactating
dairy cattle only - 35 day, slaughter withdrawal. Should not be
used within 60 days of calving.
Swine: 0.3 mg/kg subcutaneously. 18 day slaughter withdrawal
Sheep, Goats: (not approved) 0.2 mg/kg PO or subcutaneously
Reptiles: Nematodes: 200 meg/kg, repeat in 2 weeks
DO NOT USE IN TURTLES!
FORMULATIONS: EQVALAN: Equine - 1.87% paste, 1%(10

mg/ml) oral solution
IVOMEC: Cattle - 1% (10 mg/ml) for injection in
50ml
HEARTGARD (unflavored) tablets (ivermectin

only):
68 mcg for up to 25 pounds;
136 mcg for 25 to 50 pounds;
272 meg for 51 to 100 pounds
HEARTGARD PLUS Chewable for DOGS:

68 mcg + 57 mg pyrantel, for up to 25 pounds;
136 mcg + 114 mg pyrantel, for 25 to 50 pounds;
272 mcg + 227 mg pyrantel, for 51 to 100 pounds
HEARTGARD For Cats Chewable (ivermectin

only):
165 mcg, for 5 to 15 pounds
NOTE:
1. PROTECT FROM LIGHT
2. Dilutions from Ivomec and Eqvalan for oral use should be
diluted just prior to use, due to uncertain stability.
3. May be used in ferrets.
4. Vomiting after administration:
- 117 -
a. If vomiting is less than I hour after administration:

repeat the dose.
h. If vomiting is greater than 1 hour after administration,
no need to repeat the dose. Peak blood levels occur
within 2 hours of administration.
Ketamine
USE: Dissociative anesthetic/analgesic
DOSE: Cat: Anesthesia: 2 to 5 mg/kg IV or 10 to 20 mg/kg TM. Usc

lower dose for very sick cat.
Dog: Sedation: see diazepam
Horse: 2-2.5 mg/kg lV after 0.8 to 1.1 mg/kg xylazine
FORMULATlON: 100 mg/ml in 10 ml multi -dose vial
NOTE: LIGHT SENSITIVE. C-III controlled substance
Ketoconazole
USE: Imidazole antifungal agent, etfective against camlidiasis,

blastomycoses, coccidiomycosis, cryptococcosis, sporotrichosis.
DOSE: Dog: 10 mg/kg PO QD (may use up to 30 mg/kg QD); 10 to 20

mg/kg PO q 12h
Cat 10 mg/kg PO QD, give with food
Dog, Cat: FiJr malass~zig: 5 mg/kg po BID
Horse: 10 mg/kg PO (dissolved in O.2N HCI) q24h
Psittacines: Dissolve 200 mg tablet in 0.2 rnl HCI and 0.8 ml
water; give 0.05 ml to 0.1 1111 PO BID; dissolve I
tablet per quart or water.
Tortoise: 15 to 30 mg/kg q24h
FORMULA nON: 200 mg tablet
NOTE:
1. HUMAN PRODUCT
- 118 -
2. May cause nausea and anorexia - divide the dose and administer
BID.
3. Idiosyncratic hepatotoxicity can occur.
4. Requires an acidic environment tor absorption - do not
administer with antacids.
5. Double check for drug interactions.
6. May cause anorexia, vomiting in cat.
Ketoconazole, chlorhexidine gillconate, acetic acid MAL-A-KET

Pledgets
USE: An anti-fungal, anti-bacterial effective against a variety of

Gram positive and Gram negative bacteria and flll1gi. For LIse
in intertriginous dermatitis, skin folds at all locations (neck,
lip, face, anal, axillary, etc.), pododermatitis & interdigital
dcnnatitis, hot spots, and focal Malassezia & pyoderma
DOSE: Dogs, cats, horses: Wipe affected areas 2 to 3 times daily or

as directed. Use pledget (pad) once and
discard.
FORMULATION: Dispensed in jars of 50 pads; each pledget

applicator (pad) contains approximately 10 mg
ketoconazole, 20 mg of chlorhexidine glue onate,
and 20mg acetic acid.
Ketoprofen KETOFEN
USE: A non-steroidal, anti-inflammatOlY agent (NSAID), used peri-·

or post-operatively to reduce int1ammation.
DOSE: Dog: 2 mg/kg IM once, peri-op or immediately post-op

Cat: I mg/kg 1M once, peri-op or immediately post-op
FORMULA nON: 100 mg/ml in arginine vehicle (approved for usc in

horses)
- 119 -
Lactase enzyme LACT AID ULTRA
USE: For use in foals with enteritis & brush border destruction, with
relative lactase deficiency.
DOSE: Foals: 1 tablet by mouth per feeding
FORMULATION: A human over the counter product each caplet

contains 9000 FCC units
Lactic Acid, Salicylic Acid EPI-OTIC ADVANCED
USE: Cerumenolytic, antibacterial cleanser for the ear
FORMULA TION: Available in a 4 oz and 8 oz squeeze bottle
NOTE: Shake well
Lactulose CEPHULAC, CHRONULAC, generic
USE: In the treatment of hepatic encephalopathy and to reduce blood

ammonia levels
DOSE: Encephalopathy: 5 to 15 ml PO TID, can also be administered

as retention enema in comatose animal
(onstipation: 0.5 mllkg PO q8 to 12h
FORMULATION: Each 15 ml provides 10 grams oflactulose
NOTE: HUMAN PRODUCT
USE: A prostaglandin F2 alpha analogue; indicated in dogs, cats, and

horses decrease elevated intraocular pressure in patients with
open.. angle glaucoma and ocular hypertension intolerant or
insufficiently responsive to other medication .
.. 120 ..
DOSE: Place I drop in eye QD in the evening
FORMULATION: 0.005% solution in 2.5 ml dropper tip bottle
NOTE:
1. HUMAN PRODUCT - EXTREMELY EXPENSIVE
2. Protect from light.
3. Refrigerate until opened, then store at room temperature below
77°F for up to 6 weeks.
4. May cause a possibly permanent increase in brown pigment in
the iris over months to years.
Laxative - Petrolatum, Linoleic Acids, Iron LAXA TONE
USE: Laxative and lubricant used as an aid in prevention or removal

or hairballs
DOSE: Dogs: 0.5 to 2 inch ribbon of ointment 2 to 3 times a week.

Cats: 0.5 to 1.5 inch ribbon of ointment QD for 2 to 3 days,
then 0.5 to 1 inch 2 to 3 times a week
FORMULATION: 2.5 ounce tube contains white petrolatum, light

mineral oil, soybean oil, com syrup, malt syrup,
cane molasses, gelatin by-product, sodium
benzoate, iron proteinate, artificial flavors.
NOTE: Remember that most hairballs in cats are associated with

inflammatory bowel disease
Levothyroxine Sodium (T4) SOLOXINE
USE: Synthetic thyroid supplement for the treatment of

hypothyroidism
DOSE: Dog: 0.02 mg/kg ql2h, as starting dose. (For emergency

hypothyroid myxedema - 0.02mg/kg)
Cat: 0.05 to 0.1 mg PO QD, as starting dose
- 121 -
Horse: 10 mg/SOO kg PO QD
FORMULATION: 0.1 mg, 0.2 mg, 0.3 mg, 0.4 mg, O.S mg, 0.6 mg,
0.7 mg, 0.8 mg tablets; SOO mcg vial (powder for
injection)
NOTE:
1. WATCH brands - possible variations in absorption with
different brands in specific animals.
2. Powder for injection is reconstituted to 100 mcg/ml preservative
free - discard remainder.
Lidocaine 2% HCI
USE: Local anesthetic, class IB antiarrhythmic drug for ventricular

tachyrhythmias
DOSE: Dog: 2 to 6 mg/kg as a slow IV bolus over several minutes; 30

to 80 mcg/kg/min as a constant rate infusion; dilute with
NaCI or D5W to obtain a 0.2% solution (2 mg/ml)
Cat: Dose not well established, tolerates little lidocaine
Horse: Colic-loading dose 1.3 mg/kg of 2% solution over 5-
10 minutes, then 0.05 mg/kg/min (of 2%) as CRl.
FORMULA nON: 50 ml vials (human), 250 ml vials (veterinary);

jelly, 30ml tube
NOTE: Goats, especially kids, are sensitive to lidocaine; recommended

to dilute to 0.5% or 1% for nerve blocks.
CONTRAINDlCA nON: Seizures
Lidocaine 2.5% and Prilocaine 2.5% Cream
USE: Local anesthetic
122 -
DOSE: For proper application of cream - apply and cover with

occlusive dressing. Allow 1-2 hours for absorption into the
epidermal and dermal layers.
FORMULATION: 30 g tube
Lidocaine 5% Patch LIDODERM
USE: To provide localized analgesia for dogs and cats to assist in

management of incisional pain, skin and superficial muscle
pain, peripheral neuropathic pain
DOSE: Dog, Cat: 1.5 to 2.3 kg use 1/6 to y:; patch; 2.7 to 4.5 kg use 12
patch; 5 to 9.1 kg usc 1 patch; 9.5 to 18.2 kg usc 2
patches; 18.6 to 27.3 kg use 212 to 3 patches; 27.7
to 45.5 kg use 3 to 4 patches
FORMULATION: I patch (10 cm x 14 cm) provides 700mg lidocaine
NOTE:
l. Patches should be applied once during 24 hour period (human).
2. Used patches still contain large amounts of lidocaine - store and
dispose of patches out of the reach of children and pets.
3. Cut patches before removing the backing.
4. Fold used patches in half and dispose of properly.
5. Wash hands after handling patches.
6. Do not store patch outside of the scaled envelope.
Lime Sulfur 97.8% Concentrate LIMEPLUS DIP
USE: As aid in treatment ofsarcoptic mange, ringworm.
DOSE: Dogs, Cats: Dilute I oz with 1 pint to 1 quart of water and

apply topically as a dip q5 to 7 days.
FORMULATION: 4 oz bottles.
NOTE:
- 123··
University ofFlorida ........................................ Veterinary Medical Center
1. Do not store in cold areas (will precipitate).

2. Will stain; remove jewelry before using.
3. Foul odor remains 011 anything in contact with dip.
Lincomycin HCI LINCOCIN
USE: Lincosamidc antibiotic with activity against Gram negative and

Gram positive
DOSE: Dog, Cat: 10 mg/pound PO q 12 h, or 7 mg/pound PO TID
FORMULATION: 100 mg, 200 mg and 500 mg scored tablet
Lomustine (CCNU) CEENU
USE: Treatment of central nervous system neoplasia, lymphoma, mast

cell tumor
DOSE: Dog: 90 mg/m 2 every 3 weeks
FORMULATION: 10 mg capsule
TOXICITIES:
1. Neutropenia common, delayed nadir (3 to 6 weeks after drug
administration). Cumulative neutropenia reported.
2. GI toxicity infrequent
Loperamide HCIIMODJUM, generic
USE: Symptomatic control of diarrhea only
DOSE: Dogs, Cats: 0.1 mg/kg q 12h or q6h pm

Horse: 0.1 to 0.2 mg/kg PO QlD
NOTE:
- 124 -
1. HUMAN PRODUCT
2. Do not use for more than 3 days.
Lufenuron PROGRAM
USE: An insect development inhibitor which breaks the flea life cycle
by interference with chitin synthesis, polymerization, and
deposition thereby inhibiting egg development. Lufenuron has
no effect on the adult flea.
DOSE: Dog, Cat: given orally with a full meal once a month for dogs,
cats, puppies and kittens older than 6 weeks.
FORMULATION: Packaged in 6 month packs; dispensed per pack of

6 or per dose.
For DOGS* Tablet strength

11 to 20 pounds 90mg
21 to 45 pounds 204.9 mg
*Dogs are dosed at a minimum of 10 mg/kg

**Cats are dosed at a minimum ono mg/kg
NOTE:
1. MUST BE GIVEN WITH A FULL MEAL for complete
absorption which provides a full month's protection.
2. Manufacturer recommends that all dogs and cats in household
be treated to achieve greatest benefit from this product.
Lysine (L-Lysine) ENISYL-F LYSINE TREATS
USE: For use in cats to reduce the severity and duration of feline
herpes virus infection and to reduce the incidence of active
infections.
DOSE: Cats: 5 treats (250mg) by mouth twice daily for prevention
- 125 -
of infection. 10 treats (500mg) by mouth twice daily

for treatment of active infection. May give as a range
of 5 to 20 treats daily.
FORMULATION: Each treat contains 50mg L-Lysine flavored with

poultry. See package label for other additives.
Magnesium Sulfate Epsom Salts
USE: Saline laxative
DOSE: Horse: 0.5 to 1.0 gram/kg

Sheep, Swine: Adults - 25 to 125 grams po
FORMULATION: I Ib carton
Magnesium Sulfate 50% Injection
USE: For the treatment of hypomagnesemia in horse and cattle; for

the treatment of ventricular arrhythmias in horses, specifically
ventricular tachycardia.
DOSE: 10 to 20 grams IV, MUST BE DILUTED BEFORE IV USE
FORMULATION: Available as 5 gm (40.6 mEq) per 10 ml vial
Mannitol
USE: Diuretic in acute renal failure with oliguria; osmotic agent in

glaucoma - decrease intraocular pressure; to reduce cerebral
edema.
DOSE: Dog: Diuretic in oliguric acute renal failure: must fully

rehydrate the patient before treatment 0.25 g/kg IV (take 5
minutes), if oliguria persists, repeat the dose
Cerebral edema: 1 to 2 g/kg IV (take 30 to 60 minutes);
repeat q12 to 24h for next 48 hours
- 126-
Acute glaucoma: lOP> 40 mmHg: 1 to 2 g/kg IV over 30 to

60 minutes, may be repeated once in 24 hours period
Horse: 0.25 to 2 g/kg as 20% solution (200 mg/ml) by SLOW

IV infusion
FORMULATION: 12.5 gm!50 ml vial
NOTE:
1. Excessive use may induce neurological signs secondary to
hyperosmolality.
2. Contraindicated in congestive heart failure and pulmonary
edema.
3. Dissolve any crystals in vial by heating in a water bath, or
heating pad.
Marbofloxacin ZENIQUIN
USE: A synthetic, broad-spectrum anti-bacterial of the

fluoroquinolone class; with bactericidal activity against many
gram-negative and gram-positive bacteria. For use in
pseudomonas otitis media, folliculitis, furunculosis,
mycobacterium and other infections caused by susceptible
organisms.
DOSE: Dog: 1.25 to 2.5 mg/lb PO once daily; alternatively - 5 mg/kg

PO q24h (for mycobacterium)
Cat: 2 mg/kg PO once daily.
FORMULATION: 25 mg, 50 mg, 100 mg, 200 mg scored oval tablets
Note:
1. CONTRAINDICATED in dogs in the rapid growth phase and
cats less than 12 months of age due to risk of development of
arthropathies.
2. Use with caution in animals with known or suspected CNS
disorders - rarely may precipitate seizures.
3. Check for food-drug interactions, and drug-drug interactions.
- 127 -
4. The safety ofmarbof1oxacin in pregnant, lactating or breeding

animals has not been demonstrated.
5. Can be made into oral suspension.
Maropitant CERENIA
USE: A neurokinin (NKl) receptor antagonist that blocks the

pharmacologic action of substance P in the CNS, both in emetic
center and CRTZ, in dogs only.
DOSE: Dogs:
For prevention & treatment of acute vomiting: 1 mg/kg SQ q24h
for up to 5 consecutive days; onset within 1 hour.
For prevention ofacutc vomiting: minimum dose of2mg/kg PO
q24h for up to 5 consecutive days. May use tablets
interchangeably with injection for once daily dosing.
Vomiting due to motion sickness: minimum dose of 8 mg/kg PO
q24h for up to 2 consecutive days. Admininster 2 hours before
travel to dogs fasted for 1 hour prior to administration.
FORMULA nON: 10 mg/ml in 20 ml MDV; tablets, peach colored,

scored 16mg, 24mg, 60mg (blister packs of 4
tablets -- but sold by the tablet at VMC)
NOTE:
1. Vial must be Llsed within 28 days of first puncture; store
between 68 _77° F (excursions permitted between 59 and 86° n.
2. Injection is for SQ administration only.
3. The safe use of this dmg in breeding dogs, pregnant or lactating
bitches has not been evaluated.
4. The safe use of this dmg in dogs with GI obstruction, or
ingested toxins has not been evaluated.
5. Metabolized in the liver - use with caution in dogs with hepatic
dysfimction.
6. The concomitant lise of CERENIA with other protein bound
drugs (including NSAlDS, cardiac, anticonvulsant, behavior
modifying drugs) has not been evaluated·~ use with caution.
- 128 -
Medetomidine DOMITOR
USE: An alpha-2 agonist, with an alpha-2/alpha-l selectivity ratio that

is S to 10 times higher than detomidine, clonidine, xylazine;
approved in the US for sedation and analgesia in dogs.
DOSE: Dog: 10 to 40 mcg/kg 1M; S to 10 mcg/kg IV

Dog: Sedation for painful procedures - 0.1 mgllO kg (O.l mUlO
kg) IV with 3 mglkg ketamine (do NOT reverse because
dogs become catatonic due to ketamine - Milner).
FORMULATION: 1 mg/ml; 10 ml vial DISCONTINUED BY

PFIZER
SIDE EFFECTS:
1. Bradycardia with occasional A V blocks will occur together with
decreased respiratory rates.
2. Urination occurs during recovery (90 to 120 minutes post-
treatment).
3. Approximately 10% of dogs will vomit S to IS minutes post-
treatment.
4. An increase in blood glucose concentration is seen due to
insulin secretion inhibition.
MeIarsomine IMMITICIDE
USE: For the treatment of heartworm disease caused by immature

(LS) to mature adult infections ofD. Immitis in dogs
DOSE: Dog: Asymptomatic to moderate disease: 2.5 mg/kg twice, at 24

hour intervals; severe disease: 2.S mglkg once and 30 days
latcr use 2.S mglkg twicc at 24 hour intcrva1s
Administer by deep 1M injection in the epaxial muscles

(L3 - LS) ONLY. Use a 23G x 1 inch needle for dogs less
thc 10 kg; use a 22G x I liz inch needle for dogs greater
than 10 kg.
FORMULATION: SO mg vial offrcezc-dricd powdcr for reconstitution
- 129-
with 2 ml of provided diluent (sterile water)
NOTE: The reconstituted solution is stable for 24 hours if refrigerated

and kept out of the light. Return remainder to pharmacy for
hazardous waste disposal.
Meloxicam METACAM
USE: A non-steroidal anti-inflammatory drug (NSAID), of the oxicam

class. Shows selectivity for COX II inhibition, this selectivity is
diminished at higher doses. Indicated for control of pain and
inflammation associated with osteoarthritis in dogs.
DOSE: Dogs: O.2mg/kg PO, IV, SQ on Day 1, then decrease to

O.lmg/kg PO qd
Cats (not FDA approved): 0.1 mg/kg to 0.2 mg/kg PO SQ
initially, then decrease to O. I mg/kg PO qd for 2 to 4 days, then
stop OR continue at 0.025 mg/kg 2 to 3 times per week.
Alternatively: 0.1 mg/kg PO on Day 1, then 0.05 mg/kg/d
thereafter.
Cats (FDA - approved): one time dose 0.3 mg/kg SQ
Exotic Mammals: 0.05 mg/kg to 0.3 mg/kg PO, SQ once daily
(Wellehan)
Birds: 0.2 mg/kg to 0.3 mg/kg PO, SQ q12-24h
Reptiles: 0.2 mg/kg q24-48h
FORMULATION: Oral suspension (SHAKE WELL) 0.5 mg/ml and

1.5 mg/ml; solution for injection 5 mg/ml
NOTE:
1. Nearly 100% bioavailable when administered with food.
2. Peak concentrations occur approximately 7.5 hours after oral
administration.
3. Approximately 97% bound to plasma proteins
4. Safety has not been evaluated in puppies under 6 months of age,
pregnant or lactating dogs, or dogs used for breeding.
5. Use caution in dogs that are dehydrated, hypovolemic or
hypotensive - they are at increased risk for renal toxicity.
- 130-
6. Aspirin containing products &/or other NSAIDS should uot be

used while treating with meloxicam.
7, To dilute oral suspension - may use water or saline -~ dilute only
24 hours supply due to dilution of suspending agent and
preservative.
8. Dilution of injectable: because of calcium- an insoluble
precipitate is formed with drug. Dilute just prior to use,
9_ Advise owners to contact veterinarian if anorexia, vomiting or
diarrhea develops.
Meperidine HC} DEMEROL, generic
USE: Narcotic analgesic
DOSE: Dog: 5 to 10 mg/kg 1M

Cat: 2 to 10 mg/kg 1M
Horse: 2 to 4 mg/kg 1M, SQ
FORMULATION: 50 mg/ml in 30 ml vial, C-Il
NOTE:
1. May cause excitement in some horses if given IV
2, Short-acting, may require dosing every 2 to 4 hours
Mepivacaille CARBOCAINE-V
USE: Local anesthetic agent
FORMULATION: 20 mg/ml in 50 m] multi-dose vial
Methadone
USE: A potent synthetic u-opiate agonist; indicated for short term pain
control in dogs and cats; pre-anesthetic medications; in
combination with accpromazine for neuroleptanalgesia.
Provides similar analgesic properties to hydromorphone with
less vomiting and sedation.
- 131 -
University of Florida ,. ........................... ,." ....... Veterinary Medical Center
DOSE: Dog: 0.1 to 0.3 mg/kg IV q4 to 6h; 0.1 to 0.5 mg/kg 1M q4 to

6h.
Cat: O. J mg/kg JM, IV q4 to 6h.
FORMULATION: J 0 mg/ml, 20 m] multidose vial; cn.
Methazolamide
USE: Carbonic anhydrase inhibitor
DOSE: Dog, Cat: 2.5 to 10 mg/kg PO q12h
FORMULATION: SO mg scored tablet
NOTE: HUMAN PRODUCT
Methimazole
USE: For treatment of hyperthyroidism in cats; inhibits the synthesis

of thyroid hormone
DOSE: Cats: Loading dose - S mg PO BID to TID for 7 days;

maintenance dose - 2.S to S mg PO BID, begin at low
end of range and titrate to effect.
SIDE EFFECTS: Vomiting, anorexia, lethargy, granulocytopenia,

thrombocytopenia, positive ANA.
FORMULA nON: 5 mg scored tablet
NOTE: HUMAN PRODUCT
Methocarbamol
USE: A centrally acting skeletal muscle relaxant
- 132 -
University of Florida,. ...................................... Veterinary Medical Center
DOSE: Dog: 15 to 20 mg/kg PO TID

Dog and cat: 50mg/kg IV q2h for pyrethrin toxicity. 50mg/kg
IV q8-12h for other indications requiring
musele relaxation or tremor control. Maximum
daily dose 2S0mg/kg.
Horse: IS to 25 mg/kg IV slow infusion
Administer slowly IV: Do not exceed 2ml/minute in dogs and

cats. Avoid extravasation; do not administer subeutancously.
FORMULA nON: 500 mg tablet; 100 mg/mI solution for injection in

10mI Single Dose Vial.
Methotrexate
USE: Antineoplastic agent, lymphomas - crosses the blood-brain

barrier
DOSE: Dog, Cat:

1. 0.5 mg/kg (dog), 0.8 mg/kg (cat) IV q7 days for
combination lymphoma protocol.
2. 12 mg/m 2 intrathecally q2 to 5 days until CSF cellularity
decreases to normal. Concentration of injection shoLlld be I
mg/ml in preservativc free saline for injection.
3. 2.5 mg/m2 PO q24h (dog); 2.5 mg/m2 PO every other day to
every 3rd day (cat)
Dog: 0.5 mg/kg PO once.
CONTRAINDICA nONS: Neutropenia <2,000/j.1I and

thrombocytopenia <80,OOO/I.t!. Creatinine
>2 mg/dl
TOXICITIES:
1. Renal tubular necrosis has been observed with high dose
methotrexate therapy.
2. GI toxicities most common.
FORt\lIULATION: 50 mg/2ml vial; preservative free.
133 -
COMMENTS: This drug may cross the blood brain barrier and may
also be administered intrathecally.
Methylene Blue
USE: Nitrite poisoning; indicated for treatment of

methemoglobinemia
DOSE: Dog: 0.1 mg/kg IV

Bovine, Sheep: 8 mg/kg IV as 1% solution by slow IV infusion
FORMULATION: 1% (10 mg/ml) in 10 ml vial; 1% solution -16 oz.
NOTE: Contraindicated in cats: will cause the Heinz body hemolytic

anemia.
Methylprednisolone Acetate DEPO-MEDROL
USE: A glucocorticoid with repository effects
DOSE: Dog: 1 mg/kg 1M may repeat q21 to 30 days

Cat: 5 mg/kg 1M may repeat q21 to 30 days to a maximum of
20 mg per cat
Horse: Intra-articularly; 80 to 120 mg. Anti-inflammatory; 200
mgIM.
FORMULATION: 40 mg/ml suspension for injection, in 5 ml vial.

SHAKE WELL.
Methylprednisolone Sod. Succ. SOLU-MEDROL
USE: For IV treatment of pemphigus foliaceous
DOSE: Dog: 5 mg per lb IV in D5W dripped over Y2 hour

Horse: Acute CNS trauma: 30 mg/kg IV, then 5.4 mg/kg/hr for
- 134-
23 hours; anti-inflammatory: 2 to 4 kg/kg IV or 0.5

mg/kg IV, 1M
FORMULATION: 125 mg, 500 mg vial
NOTE:
1. HUMAN PRODUCT.
2. Solution may be stored at room temperature after mixing and
used within 48 hours or 72 hours (check label).
Metoclopramide
USE: Antiemetic, raises lower esophageal sphincter pressure, and

promotes gastric emptying
DOSE: Dog, Cat: 0.2 to 0.4 mg/kg PO or SQ TID

Foal: To stimulate GI: 0.02 to 0.1 mg/kg 1M, IV TID to QID;
DO NOT use in adults.
FORMULATION: 10 mg tablets; 1 mg/ml syrup; 5 mg/ml injection in

2 ml SINGLE DOSE vial. Protect from light
Metronidazole
USE: Nitroimidazole used to treat giardia and other protozoal

infections. Very effective against anaerobic bacterial infections.
DOSE: Dog: Giardia and other protozoal infections: 30 to 60 mg/kg PO

QD for 5 days. Bacterial overgrowth and anaerobic
infections: 12 to 20mg/kg PO QD or BID; 15 mg/kg
loading dose IV, then 7.5mg/kg IV q6h
Cat: Giardia and other protozoal infections: 25 to 30 mg/kg PO
QD for 5 days.
Horse: 25 mg/kg PO ql2h, OR 35 mg/kg PR q12h.
Raptors: Trichomoniasis: 16.5 mg/kg PO BID for 5 days.
Reptiles: Amoeba: 100 mg/kg PO, repeat in 2 weeks (except
Indigo and Milk Snakes, dose at 40 mg/kg).
Flagellates: 100 mg/kg PO, repeat in 2 weeks
- l35 -
University ofFloridL ...................................... Veterinary Mcdical Ccnter
FORMULATION: 250 mg and 500 mg tablet. Compounded (from

benzoate) to 100 mg/ml oral suspension; For
injection - 500 mg per 100 ml Preservative-FREE.
PROTECT FROM LIGHT
NOTE:
1. Prolonged high doses particularly witb the IV form can cause
neuropathies
2. Recommend to begin at lower dosage range.
MexHetine
USE: An antirrhythmic agent, similar to lidocaine, usc to trcat

ventricular tachyrrhythmias.
DOSE: Dog: 4 to Smg/kg PO q8h
FORMULATION: 150mg, 200mg, 250mg capsule
NOTE: HUMAN PRODUCT
Miconazole CONOFITE, ResiZOLE, MONIST AT 7
USE: Antifungal with activity against cryptococcosis, candidiasis,

coccidiomycosis, malassezia pachydermatis (sbampoo).
DOSE: Topical: apply daily for 2 to 4 weeks

Shampoo: 1 to 2 times a week
FORMULATION: 1'% lotion (CONOFITE) in 30 ml dropper tip

bottle; 2% cream in 30 gram tube; 2% Leave-on
conditioner RESIZOLE 8 oz
Miconazole nitrate, polvrnvxin B sulfate, prednisolone acetate

SUROLAN
.. 136 -
USE: For the treatment of canine otitis externa associated with

Malassezia pachydermatis and bacteria Staphylococcus
pseudo intermedius.
DOSE: Dogs: instillS drops into ear canal twice daily. Massage the ear
after application. Treat for 7 consecutive days.
FORMULATION: Otic suspension; 30ml bottle with applicator tip.
NOTE:
l. Shake well before use.
2. Verify eardrum is intact before beginning therapy.
3. Thorougly clean and dry external ear before intitiating
treatment.
Midazolam
USE: Short-acting, water soluble benzodiazepine, used for sedation,

as a premedicant for general anesthesia, or for status epilepticus.
Use in combination with opiods or ketamine for more
predictable level of sedation.
DOSE: Dog, Cat: 0.1 to OAmg/kg IV or 1M.

Bird: 0.5 mg/kg 1M
Horse: For seizure control in foals: 2 to Smg total dose for a
SOkg foal given slowly IV or 1 to 3 mg/hour as a CRI
for a SOkg foal.
FORMULATION: S mg/ml in 1 ml and 10 ml vial
NOTE:
l. HUMAN PRODUCT, C-IV controlled substance.
2. Labeled for use in human IV, 1M.
3. Stings on injection.
4. Implicated in increased aggression in Felidae.
MicroLactin DURALACTIN
- 137 -
USE: A natural milk protcin from thc milk of hyperimmunized cows

that contains factors that appear to block cytokines to inhibit
ncutrophil participation in the inflammatory response.
DOSE D og:
Under 40 pounds Y, tablet twice a day
40 to 80 pounds 1 tablet twice a day
81 to 120 pounds 1 Y, tables twice a day
Over 120 pounds _ 2 tablcts twice a day
FORMULATION: 1OOOmg vanilla flavorcd chew tablct
Milbemycin Oxime INTERCEPTOR Flavor Tabs
USE: In dogs, a once a month heartworm preventative, that also

provides control of hookworm infestation, and removal and
control of roundWOnll and whipworm infestation. In cats, a once
a month heamvorm preventative, a Iso for removal of hookworm
and roundworm infestations.
DOSE: Dog: Once a month, PO, at a rate of 0.5 mg/kg

1---------------------------
Tablet strength
j
Wcight
51 to 100 pounds 123 mg
For demodicosis: 1 to 2 mg/kg PO QD, maximum dose of

2.5 mg/kg
Cat: Oncc a month, PO, at a ratc of 2 mg/kg
- 138 -
FORMULATION: Flavor tabs; may be purchased per tablet or per 6

tablel strip
NOTE:
l. Recommended for puppies at least 8 weeks of age and 2 pounds,
and kittens at least 6 weeks of age and 1.5 pounds
2. Vomiting after dose: if 1 hI' or less after administration- repeat
dose; if longer than 1 hr - DO NOT need to repeat dose - dose
is absorbed, peak blood levels in 2 hrs after administration.
]\1i1bemycin Oxime/Lufenuron SENTINEL Flavor Tabs
uSE: A combination product used to prevent heartworm disease, as

well as to control hookworms, roundworms, whipwOfms and
flea populations in dogs.
DOSE: Dog: Once a month, PO, at a rate 01'0.5 mg/kg milbemycin

oxime and 10 mg/kg lufenuron; given with or immediately after
a full meal.
,-----------------.--------
Wei ht Tablet stren -th milb/luf
2 to 10 pounds 2.3 mg/46 mg (brown)
11 to 25 pounds I 5.75 mgll15 mg (green)
26 to 50 pounds I 11.5 mgl/230 mg (yellow)
5] to 100 ollnds I 23 mg/460 m ' (white)
FORMULA nON: Flavor tabs; may be purchased per tablet or per 6

tablet strip
NOTE: Do not usc in puppies less than 4 weeks of age or less than 2
pounds of body weight
Milk Thistle Seed Extract
USE: Primarily used as a hepatoprotectant and antioxidant
DOSE: Dog: 0.25 ml (small), 0.5 ml (medium), 1 ml (large) PO q8 to

12h
- 139 -
Cat: 0.25 ml to 0.5 ml PO q8 to 12h
FORMULATION: Organic milk thistle seed providing dry herb

strength of 1000 mg/ml
Milrinone
USE: A bipyridine compound that acts primarily to inhibit

phosphodiesterase in myocardial and arteriolar smooth muscle
cells, leading to its affects as a positive inotropic and systemic
arterilar dilating agent.
DOSE: For treatment of acute congestive heart failure or cardiogenic

shock in humans and possibly dogs; administer IV as CRI @ 1
to 3 mcg/kg/min.
FORMULATION: 50 mg/50 ml SDV
NOTE: Loading dose my be administercd undiluted, solution should

be diluted prior to maintenance dose administration. May use
0.9% saline, D5W for diluents.
Misoprostol CYTOTEC, generic
USE: A synthetic prostaglandin E1 analog, which has both

anti secretory and mucosal protective properties. Used for the
prevention on NSAID (including aspirin) induced gastric ulcers.
Misoprostol does not prevent duodenal ulcers.
DOSE: Dog: 3 to 4 mcg/kg BID to TID; 100 mcg per large breed dog.
Doses should be administered with food to minimize
incidence of diarrhea.
Horse: 1 to mcg/kg PO q 12h
FORMULATION: 100 mcg tablets - SPECIAL ORDER
NOTE:
1. Misoprostol has ABORTIFACIENT properties
- 140 -
2. Common adverse reactions include: a dose-related diarrhea,

which may be self-limiting or may require discontinuation of the
drug; abdominal pain
3. Can NOT be made into a suspension/solution per manufacturer
- NOT stable. Crush tablet, add water and give dose
immediately, do not save any remainder.
Mitotane LYSODREN, o,p'-DDD
USE: Adrenocorticolytic agent
DOSE: Dog: Endogenous hypercortisolism: 50 mg/kg PO QD to effect

(generally 7 to 10 days), then 25 mg/kg PO q3 days.
Recommend giving prednisone at 0.3 mg/kg/day during loading
period.
Dose adjustments may be necessary in patients with liver

diseases as up to 60% of the drug is excreted unchanged in the
stool. Very old debilitated or diabetic dogs should receive 25 to
35 mg/kg as loading and maintenance dose.
FORMULATION: 500 mg scored tablet
CONTRAINDICATIONS: Hypersensitivity and adrenocortical

insufficiency.
TOXICITIES: Nausea, anorexia, vomiting, diarrhea and CNS

depression. Treat with glucocorticoids primarily; give
FLORINEF ifhyperkalemiaihyponatremia occur.
COMMENTS: Discontinue temporarily following shock or severe

trauma since the prime action of mitotane is adrenal
suppression. Adrenal insufficiency may develop.
Consider adrenal steroid replacement for these patients.
Morphine Sulfate
USE: Narcotic analgesic
- 141 -
University of Florida ............. " ......................... Veterinary Medical Center
DOSE: Dog: Analgesia: 0.5 to 1.0 mg/kg SQ, 1M; or 0.25 mg to 0.3
mg/kg SQ, 1M q4 to 6h PRN; 0.5 ~ 4 mg/kg PO q6 to 8h
Pre-anesthesia: 0.1 to 0.2 mg/kg SQ
Cat: Analgesia: 0.05 to 0.1 mg/kg SQ; 1 mg!kg q6 to 8h (oral
solution)
Horse: 0.2 to 0.4 mg/kg IM......,.duration I to 2 hours (must be in
addition to sedative such as xylazine 0.5 mg/kg IV)
Swine: 0.2 mg/kg up to 20 mg total dose
Sheep, goat: Uup to 10 mg total dose
FORMULATION: 10 mg/ml in 1 ml vial or MDV; 1 mg/ml

preservative free (DURAMORPH), 10 ml ampules
NOTE:
1. HUMAN PRODUCT. C-II controlled substance
2. High concentration morphine (lOmg/ml) may affect red cell
morphology, K+, or enzyme levels in transfused blood (human).
I mg/ml or lower (in saline) does not (J Pain Symptom Manage
2001; 22(2):668-71).
Moxideetin 2% QUEST GEL
USE: Treatment of ivennectin resistant Haemonchus ssp in goats -

unapproved. A dewormer and boticide in horses and ponies.
DOSE: Horse: 0.4 mg/kg PO

Goat: One notch on syringe per 50 pounds (unapproved)
FORMULA nON: 20 mg/ml oral gel, 11.3 g tube is marked in 50

pound increments.
NOTE: Do not use in horses and ponies under 4 months of age. Do not
use in horses intended for food. Wash hands after
administration.
Moxidectin 2%, Praziquantel12.5% QUEST PLUS
- 142 -
University ofFlorida ..... « ............ « ...... " ••••••• " •• Veterinary Medical Center
USE: An equine dewormer indicated for treatment of roundworms and

tapeworms in horses and ponies.
DOSE: Horse: Refer to dosing nodules on oral syringe.
FORMULA TION: Oral gel; syringe treats 1250 pounds
NOTE:
I. Do not use in horses and ponies under 4 months of age.
2. Do not use in horses intended for food.
3. Wash hands after administration.
Mupirocin 2% Ointment
USE: Topical antimicrobial agent
FORMULATION: 22 gram tube
Mvcobacterium Cell Wall Fraction (BCG)
USE: Immunostimulant
FORMULA.TION: 10 ml vial
Naloxone HCL
USE: Pure narcotic antagonist - use in the treatment of opiate

toxicities
DOSE: Dogs, Cats: 1M, IV, or SQ

Horse: 0.01 to 0.02 mg/kg IV
FORMULA nON: 0.4 mg/m1 in 10 ml multi-dose vial
NOTE: Since the duration of action is 1 to 4 hours - which may be

shorter than that of the narcotics being reversed - observe the
animal until all signs ofnareotic toxicity are gone.
- 143 -
University of Florida ........................................ Veterinary Medical Ccntcr
Natamycin NATACYN
USE: Ophthalmic antifungal agent for fungal and yeast keratitis
DOSE: 0.2 ml4 to 6 times a day, via lavage or topically to the eye.
FORMULA TION: 5% suspension, 15 ml bottle with dropper
NOTE: For lavage systems, the sllspension is diluted to 3.33% with

sterile water to facilitate movement through the lavage system
Neomycin Sulfate
USE: The only indication for this drug in dogs and cats is as
adjunctive therapy in the control of hepatic encephalopathy. Can
cause intestinal mucosal damage and diarrhea. Also used in a
0.25% solution in saline for wound flush.
DOSE: Dog, Cat: 20 mg/kg PO q8 to 12h

For hepatic encephalopathy: as an enema at 15
mg/kg q6h
Psittacines: 7 to 10 mg/kg PO, divide total dose TID for enteric
infections
Note: no systemic absorption unless mucosal ulcerations

present. toxic if absorbed. Use preparations without
anticholinergics, may be used with kaolin/pectin preparations.
FORMULATION: 200 mg/ml (140 mg neomycin base)
NOTE:
1. Aminoglycoside-0poorly absorbed following oral
administration,
2. Neomycin-methscopolamine products have been withdrawn
from the market.
- 144 -
University of Florida ... 0< . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Veterinary Medical Center
Neomycin, Polymyxin D, Dexamethasone 0.1 % Ophthalmic
USE: For steroid responsive int1ammatory ocular conditions for which

a corticostcroid is indicated, and where bacterial ocular infection
exists
DOSE: Use 1 to 2 drops, or a small strip, in eye QD to QID, or 0.2 cc

via lavage (equine)
FORMULA TION: Ophthalmic suspension (SHAKE WELL) in 5 ml

dropper tip bottle; ophthalmic ointment in a white
petrolatum and mincral oil base, 3.5 gram tube
NOTE: HUMAN PRODUCT

-----_._---
Neomycin, Polymyxin S, Gramicidin Ophth Solution Triple

Antihiotic Ophthalmic Solution
USE: Fo[ the trcatment of corneal ulcers, conjunctivitis
DOSE: Apply 1 drop QID in affected eye(s), or 0.2 cc per lavage

(equine).
FORMULATION: Supplied in 10 ml dropper tip plastic bottle.
Note: HUMAN PRODUCT
Neomycin, Polymyxin E, Hydrocortisone 1% Otic Solution
USE: For the treatment of superficial infections of the external

auditory canal.
DOSE: Apply TID to QID.
FORMULATION: Supplied in 10 ml glass bottle with dropper
NOTE: Contains metabisulfite as a preservative.
- 145 -
HUMAN PRODUCT. EXPENSIVE.
Neostigmine Methylsulfate
USE: Cholinesterase inhibitor; use in treatment of myasthenic crisis or

botulism. As a reversal agent for non-depolarizing muscle
relaxants.
DOSE: Small Animal reversal of non-depolarizing muscle relaxants:

0.01 to 0.02 mg/kg IV in conjunction with
atropine/glycopyrrolate to avoid fatal bradycardia
Horse: 0.4 mg to 2 mg per 100 kg SQ treatment of paralytic
ileus oflarge colon: 0.02 mg/kg SQ (may delay gastric
emptying)
FORMULATION: 1 mg/ml in 10 ml multi-dose vial
NOTE: Do not administer to animals in late pregnancy or those with

gastrointestinal or urinary tract obstructions. Milk will be
contaminated - only for non-lactating cattle.
Nitenpyram CAPSTAR
USE: An ORAL treatment of flea infestations on dogs and cats
DOSE: Dogs and Cats 2 to 25 pounds: one 11.4 mg tablet

Dogs 25 to 125 pounds: one 57 mg tablet
Dogs 125 to 150 pounds: one 11.4 mg and one 57 mg tablet
Dogs over 150 pounds: two 57 mg tablets
FORMULATION: 11.4 mg and 57 mg tablets; available by the single

tablet, or boxes of 6 doses
NOTE:
1. Safe for dogs and cats over 4 weeks of age and greater than 2
pounds, pregnant or nursing.
2. Tablets may be administered daily if needed.
- 146 -
3. Begins killing fleas in 30 minutes.
Nitrofurantoin macrocrystals MACRODANTIN, generic
USE: For the treatment of urinary tract infections due to susceptible

strains ofE. Coli, enterococci, S. aureus, and certain susceptible
strains of Klebsiella, Enterobacter, and Proteus species.
DOSE: Dog: 4 mg/kg PO qSh, should be given with food
FORMULATION: 50 mg capsule - SPECIAL ORDER
Nitrofurazone Soluble Dressing
USE: For prevention or treatment of surface bacterial infections of

wounds, bums
DOSE: Apply to lesion q6 to 24h
FORMULATION: 16 ounce jar
Nitroglycerin Ointment 2%
USE: Venous vasodilator; used for acute laminitis and congestive

heart failure.
DOSE: Dog: 0.25 to I inch cutaneously q6-Sh.

Horse: Apply 15 to 20 mg of ointment to each digital vessel, up
to 0.3 mg/kg/day, once daily [2 limbs = SO mg total; 4 limbs =
160 mg total]. Monitor effectiveness by tail cuff blood pressure;
dose dependant response in systemic blood pressure should be
seen.
FORMULA TION: 1 gram tube with calibrated application papers; I

inch delivers approximately IS mg (per
manufacturer)
- 147 -
NOTE: HUMAN PRODUCT. Wear rubber gloves. Wash hands after

use.
Nitroprusside NITROPRESS
USE: An immediate acting intravenous hypotensive agent that causes

peripheral venous and arterial dilation independent of autonomic
innervation.
DOSE: Dog: 0.5-10 mcg/kg/min CRI, titrate as needed.
FORMULATION: 50 mg/2 ml vial
NOTE: Must be DILUTED before IV infusion. Add 2 to 3 ml D5W to

50 mg vial to dissolve powder. Add dissolved solution to 1000
ml ofD5W and promptly protect solution from light.
EXTREMELY light sensitive! Wrap infusion in foil or other
opaque material. Resultant solution contains 50 microgram/ml
of nitroprusside. Higher concentrations may be necessary in
treating larger animals. Discard solution after 24 hours.
SIDE EFFECTS: Excessive doses, prolonged therapy, a depleted hepatic

thiosulfate (sulfur) supply, or severe hepatic or renal
insufficiency may lead to profound hypotension,
cyanogen or thiocyanate toxicity. Metabolic acidosis
and tolerance to therapy may indicate early cyanogen
toxicity.
Norepinephrine bitartrate LEVOPHED Injection
USE: A powerful peripheral vasoconstrictor acting on arterial and

venous beds (alpha adrenergic), and a potent inotropic on the
heart (8 1 adrenergic). Requested by LAM for hypotension in
foals unresponsive to fluid therapy and 8 1 agonists.
DOSE: Foal: 0.03 to 3.3 mcg/kg BW per minute. (Highest reported

dose used 1.5 mcg/kg BW per minute - Franklin)
- 148 -
FORMULATION: 4 mg/4ml ampule
NOTE: lnh.lse into a large vein to prevent extravasation, which can

cause necrosis and sloughing - phentolamine as antidote to
cxtravasation. Dilute in D5W or D5W in saline. According to
manufacturer, 0.9% saline alone as diluent may cause
signitlcant loss of potency from oxidation. See Handbook On
Injectable Drugs for additional (contradictOlY) stability
information.
Nystatin
USE: Treatment of candida infections
DOSE: Dog, Cats: 100,000 units PO q6h

Psittacines: 200,000 to 300,000 unitslkg TID, QID
Reptiles: 100,000 u/kg q24h
FORMULA TION: 100,000 units per ml oral suspension, dispensed by

the ml
Nystatin, :,<eomycin Sulfate, Thiostrepfon. Triamcinolone Acetonide

ANIMAX
USE: Treatment of topical, otic bacterial and/or fungal infections

which also require an anti-inflammatory agent
DOSE: 3 to 5 drops (or a thin film) from BID to TID to once a week as
needed.
FORl\1ULATION: 15 gram crcam; 15 ml, 30 ml, 240 ml ointment-

check with pharmacy for availability
Omeprazo]e PRlLOSEC-OTC, GASTROGARD
USE: Suppresses gastric acid secretion by specific inhibition of

H1'/K + ATPase enzyme system at the gastric parietal cell; used
- 149 -
in the treatment of gastric ulcer disease, severe gastritis, reflux

esophagitis.
DOSE: Dog, Cat: 0.7 to 1.0 mg!kg PO once daily

Horse: 4 mg!kg PO once daily for 28 days (treatment) then 2
mg/kg for 30 days (to prevent recurrence).
FORMULATION: 20 mg delayed release tablet; Paste: 37%w!w as a

tlavored paste in an adjustable dose syringe; each
tube contains 2.28 grams of omeprazole, sufficient
to treat a 12S0-1b horse.
9ndansetron
USE: A SlIT 3 receptor antagonist, used as an antiemetic
DOSE: Dog: Antiemetic - 0.1 to 1 mg/kg PO q 2 to 24 h.

Intractable vomiting - 0.11 to 0.176 mg/kg slow JV push
q 6 to 12 h
Cat: Antiemctic for intractable vomiting· 0.1 to O.lSmg/kg
slow IV push q 6 to 12 h
FORMULATION: 2 mg/1ll1 solution for injection.
NOTE: Check for incompatibilities in syringe. and Y.·site.
Ophthalmic Irrigation Solution
USE: Eye wash
DOSE: To rinse, flush or irrigate eyes
FORMULA TION: 4 oz bottle contains purified water, sodium

phosphate, potassium chloride, sodium hydroxidc,
and sodium chloride. Preserved with EDTA and
benzalkonium chloride,
150 -
Oxytetracycline HCI
USE: A bacteriostatic antibiotic with activity against many gram

positive and gram negative bacteria, several rickettsiae,
mycoplasma and spirochetes
DOSE: Beef and non-lactating dairy: 3 to 5 mg/pound 1M or IV q24h

using 100 mg/ml
FORMULATION: 100 mg/ml in 500 ml injection bottles;
NOTE: DO NOT USE IN LACTATING DAIRY CATTLE. Refer to

product label for meat withdrawal times
Oxytetracycline base LA 200
USE: A bacteriostatic antibiotic with activity against many gram

positive and gram negative bacteria, several rickettsiae,
mycoplasma and spirochetes
DOSE: Beef, non-lactating dairy: 3 to 5 mg/pound 1M q3d; no more

than 10 cc per site
Swine: 9 mg per pound 1M; no more than 5 cc per site
Foal: For tendon contracture: 2 grams slow IV, diluted in
500 ml saline
FORMULATION: 200 mg/ml in 100 ml injection bottle
NOTE: DO NOT USE IN LACTATING DAIRY CATTLE. Refer to

product label for meat withdrawal times
Oxytetracycline, Polymyxin B sulfate Ophthalmic Ointment

TERRAMYCIN
USE: For the treatment of superficial ocular infections
DOSE: Dog, Cat, Sheep, Cow, Horse: Apply to the eye BID TO QID
- 151 -
FORMULA nON: 3.5 g tube
NOTE: Do not use in veal calves. A withdrawal period has not been
established in prennninated calves.
Oxytocin
USE: A posterior pituitary honl1one; used to induce parturition,

evacuate uterine contents and decrease uterine hemorrhage
following parturition; also used to stimulate milk let-down
DOSE: Dog: 3 to 20 units 1M; repeat evcry 30 minutes for 3 total

treatments
Cat: 2.5 to 5 units 1M every 30 minutes for 3 total treatments
Cattle: 60 units IV, 1M or SQ for adults (100 units IV by slow
infusion)
Horse: 10 to 20 units IV, 1M to promote uterine clearance
For csophagcal obstmction (choke): 0.11 to 0.22
units/kg IV
Sheep, swine: 5 to 10 units IV, 20 to 50 units 1M or SQ
For milk let-down:

Bovine: 20 to 40 u IV, 1M or SQ
Swine: 5 to 10 u IV, 20 to 50 u 1M or SQ
FORMULATION: 20 units/ml in 100 ml multi-dose vials, refrigerated
Pamidronate disodium
USE: A bisphosphonate used for treating hypercalcemia with Vit D

analog toxicity or hypercalcemia of malignancy; also,
investigational use as adjuvant treatment of osteosarcomas.
DOSE: Dog: Malignant bone diseasc - 1 mg/kg IV as a 2 hour constant

rate infusion.
Dog: Hypercalcemia - 1.3 to 2 mg/kg IV as a 2 hour infusion
(diluted in 150 ml 0.9% saline)
- 152 -
FORMULATION: 30mg/l0 ml vial to be further diluted for infusion.
NOTE: Do not mix with calcium containing solutions. Administer in a

single IV solution; in a line separate form all other drugs.
Pancreatic Enzymes PANCREZYME
USE: Pancreatic enzymes from porcine pancreas, for animals with

deficient exocrine pancreatic secretions
DOSE: Dog: 2 teaspoonsful with meals (in food) for 20 kg dog

Cat: lj, teaspoonful with meals (in food) for 4 kg cat
Mix well with food. Frequent smaller meals usually give best
results.
FORMULATION: Available in 4 oz and 12 oz bottles; powder to be

added to food: each teaspoonful contains, lipase
71,400 USP units, protease 388,000 USP units,
and amylase 460,000 USP units.
NOTE: Wash any powder off skin, avoid inhaling dust
Pancuronium Bromide
USE: A nondepolarizing neuromuscular blocking agent.
DOSE: Dog, cat: O.Ol-O.lmg/kg IV.

CAUTION: Use only in conjunction with a general anesthetic.
Use with caution in patients with renal insufficiency.
FORMULATION: 1 mg/ml, 10 ml vial, HUMAN PRODUCT
NOTE:
1. To be used only by professionals familiar with using
neuromuscular blocking agents.
2. Provide adequate ventilator support
- 153 -
Penicillamine CUPRIMINE
USE: For chelation of cystine, lead, and copper; used in the

management of cytine urolithiasis, lead poisioning and hepatitis
associated with lead accumulation.
DOSE: Birds: 52 mg/kg PO BID
NOTE: HUMAN PRODUCT
Penicillin G Potassium
USE: Bactericidal antibiotic with activity against many gram positive

organisms, anaerobes, and fusospirochetosis
DOSE: Dog, Cat: 20,000 u/kg IV, 1M, SQ q4h

Horse: 20,000 to 40,000 u/kg SLOW IV q6h.
Cattle: 20,000 u/kg IV q6h
FORMULATION: 20 million unit as powder for reconstitution to

500,000 units per ml.
NOTE: 1 million units contain 1.7 mEq of potassium.
Penicillin G Procaine
USE: Bactericidal antibiotic with activity against many gram positive

organisms, anaerobes, and fusospirochetosis; longer acting but
with lower blood levels than penicillin G potassium
DOSE: Dog, Cat: 20,000 u/kg 1M, SQ q12 to 24h

Horse: 22,000 to 40,000 u/kg 1M q12 to 24h
Bovine: 20,000 u/kg 1M q12 to 24h (72 hours milk and 10 day
slaughter withdrawal)
- 154 -
University of Florida .................... " .................. Veterinary Medical Center
FORMULATION: 300,000 u/ml suspension, in 100 rnl and 250 ml

multi-dose viab
NOTE:
l. STORE IN REFRIGERATOR & SHAKE WELL.
2. Food Animals - extra-label dosage, withdrawal times may be
variable.
Penicillin G, Procaine/Benzathine
FORMULATION: 150,000 units procaine penicillin G plus 150.000

units benzathine penicillin G per ml
NOTE:
1. NOT FOR USE IN LACTATING DAIRY CATTLE.
2. STORE IN REFRIGERATOR & SHAKE WELL.
Pentobarbital NEMBUT AL
USE: Sedation and anesthesia, pre-medication for myelogram
DOSE: Dog, Cat: Status epilepticus: 3 to 15 mg/kg IV slowly to effect.

Pre-med for myelogram: 5 mg/kg 1M
General anesthesia: 20 to 30 mg/kg IV, inject second
half of dose slowly to effect
Horse: 3 to 15 mg/kg IV single dose
Ruminants, swine: 15 to 30 mg/kg IV single dose
FORMULA nON: 50 mg/ml MDV - HUMAN
NOTE: 1. HUMAN PRODUCT. C-fI controlled substance.

2. Veterinary product is 65 mg/ml - we do not stock.
Pentobarbital, Phenytoin BEUTHANASIA-l) SPECIAL
USE: Euthanasia solution for IV or intra-cardiac usc, labeled for dogs

only
- 155 -
DOSE: 1 ml for each 10 pounds of body weight (most clinicians use

several ml's extra)
FORMULATION: Each ml contains: 390mg pentobarbital sodium,

50mg phenytoin sodium in 10% ethyl alcohol,
18% propylene glycol, rhodamine B, benzyl
alcohol, water for injection. Available in 100 ml
vials. This is a non-sterile solution.
NOTE: C-III controlled substance. Very thick~use 18 G or 14 G

needle; consider LuerLock syringe. Avoid contact with broken
skin and self-inflicted injections
PentoxifyUine
USE: A hemorrheologic agent for treatment of horses at risk for

developing endotoxemia, treatment of endotoxemia, laminitis,
microvascular thrombosis, aortic - iliac thrombosis
DOSE: Horse: 8.5 mg/kg PO q8 to 12h

Bird: 15 mg/kg to 25 mg/kg PO Q8H to Q12H
FORMULATION: 400 mg coated tablet
NOTE: HUMAN PRODUCT
Permethrin 45% KIL TIX
USE: Insecticide for dogs only, provides tick control for up to 3 to 4

weeks.
DOSE: Dogs less than 33 pounds: One tube (1.5ml) between shoulder
blades once every 3 weeks.
Dogs greater than 33 pounds: One tube between shoulder blades
and one tube at base of tail.
- 156-
FORMULATION: Individually sealed tubes of 1.5ml each. No charge

for patients also using ADVA NTAGE for i1ea
control.
NOTE:
I. DO NOT USE ON CATS. Toxic to cats when wet, minimum
drying time of 8 hours should be allowed - once dry, not toxic to
cats (per Bayer)
2. Do not use in dogs less than 12 weeks of age.
Permethrin 2% FLYPEL Spray for Horses
USE: Spray for horses, provides protection against biting and nuisance
insects, ticks, mosquitoes and gnats.
DOSE: Spray to wet hair thoroughly; avoid spraying directly on face,

apply with cloth or sponge. Repeat as needed.
FORMULATION: I gallon bottle will be discontinued when

inventory is depleted
NOTE: Do not use on horses to be used for food. Contains sunscreen

and silicone.
Permethrin 2%, I>yriproxyfen 0.05% Spray KNOCKOUT with

Nylar
USE: Insecticide spray with growth regulator to kill fleas and ticks for
ADUL T DOGS ONLY
DOSE: Dog: Wct the coat to the skin every 2 weeks. Allow to air dry,
or blow dry.
FORMULATION: 16 oz bottle with sprayer
NOTE:
1. DO NOT USE ON CATS.
2. Avoid inhaling spray mist, do not get on skin or in eyes.
~ 157 -
Petrolatum White VASELINE, generic
USE: Ointment base, lubricant, moisturizer.
DOSE: Topically
FORMULATION: 1 lb jar
Pharyngeal Flush Solution
USE: For flushing equine pharynges
FORMULATION: Compounded in Pharmacy following one of below

recipes. Please specify formulation desired on
each written prescription.
1. Neomycin sulfate, isoflupredone acetate inj, glycerin, sterile

water; dispensed in 350ml quantities- 50ml of99% DMSO
may be added.
2. Neomycin sulfate, dexamethasone sodium phosphate 4mg/ml
inj, glycerin, sterile water; dispensed in 350ml quantities --
SOml of 99% DMSO may be added.
NOTE: Wear rubber gloves when handling solution after DMSO is

added.
Phenobarbital
USE: Barbiturate used in treatment of seizure disorders
DOSE. llorse: Loading dose: 20 mg/kg slow IV illfusion, then 1 to 10

mg/kg IV or PO q8 to 12h
Dog, Cat: Begin with 2 mg/kg PO BID
FORMULA nON: Tablet: 15 mg (v" gr). 30 mg (/2 gr), 60 mg or 64.8

mg (I gr)
- 158 -
Oral Liquid: 20 mg/5 ml (a1cohol13.5%)

Injection: 65 mg per I ml vial for injection
NOTE:
1. C-IV controlled substance.
2. 1 gram causes serious poisoning in adult human; 2 to 10 grams
can be lethal in adult human.
3. Monitor serum levels after steady state reached (14 - 16 days in
dog, 9 days in cat). Pull serum sample just before next
scheduled dose - effective serum range 14 to 40 mcg/ml.
Phenoxybenzamine
USE: A halo alkylamine that blocks both presynaptic and postsynaptic

a-adrenergic receptors. Forms a stable covalent bond with the
receptor site and; once attached, the effect is not antagonized by
competitive inhibitors. Blocks both ~l and ~2 receptors. Used to
inhibit smooth muscle contraction of the urethra in detrusor
sphincter dyssynergia and following urethral obstruction in cats.
DOSE: Dog: 0.25 to 0.5 mg/kg PO q8h

Cat: 2.5 to 5.0 mg PO q12h
Horse: 0.7 to 1.2 mglkg IV, then 0.6 mg/kg PO q8h for 2 doses
FORMULATION: Available as a compounded product, 5 mg/ml.

Mininum amount that can be compounded is 24m!'
NOTE:
1. Hypotension and tachycardia may occur at high doses. Always
start with low doses.
2. Insoluble in water; soluble in alcohol, propylene glycol (per
SKB 4/96)
Phentolamine mesylate
USE: Indicated for prevention or control of hypertensive episodes that

may occur during surgery in patients with pheocromocytoma;
also used for treatment or prevention of dermal necrosis and
- 159 -
University of Flori da ........................................ Veterinary Medical Center
sloughing due to IV administration or extravasation of

norepinephrine; also used in the diagnosis of
pheochromocytoma by the phentolamine blocking test.
DOSE: TM or IV
FORMULATION: 5 mg to be reconstituted in 1 011 sterile water, use

immediately, discard remainder
Phenylbutazone
USE: Non-steroidal anti-inflammatory, with analgesic and antipyretic

actions
DOSE: Horse: 2 to 4 mg/kg IV or PO BID

Cattle, swine: PO 4 to .8 mg/kg every 2 days or IV 2 to 5mg/kg
FORMULATION: 1 gram tablet; 200 mg/ml injection (refrigerator);

12 g paste for horses
NOTE: Cannot be given 1M to horses. Can cause bone marrow

dyscrasia and G1 ulceration. Do not use in animals intended for
human consumption.
Phenylephrine
USE: A postsynaptic alpha-receptor stimulator with strong peripheral

vasoconstrictive action, used as a second line treatment for
equine hypotension nOll-responsive to treatment of first choice
dming anesthesia.
DOSE: By infusion, to eficct.

Horse: 5 mglV slow infusion
Horse- wi~m: 10mg of 1% solution injected directly into
erect corpus cavcl110sum penis (ref Priapism in Horses
Compcndium April 2005, p311)
FORMULATION: 10 mg/ml in 1 ml vials
- 160 -
NOTE: HUMAN PRODUCT
Phenylephrine 0.5% Nasal Spray
USE: Nasal decongestant
FORMULATION: 15 ml squeeze bottle
Phenylephrine Ophthalmic Solution
USE: A mydriatic agent; also used in the symptomatic treatment of

Homer's syndrome.
DOSE: Use 1 drop every 4 to 6 hours.
FORMULATION: 2.5% in 15 m); 10% in 5 ml dropper tip bottle.
NOTE: HUMAN PRODUCT
Phenylpropanolamine HCL PROIN
USE: A sympathomimetic amine used for the treatment of urethral

sphincter hypotonus and associated incontinence
DOSE: Dog: 0.5 to 1.5 mg/kg PO q8 to 12 h

Horse: 0.5 to 2 mg/kg PO q12h
FORMULA nON: 25 and 50 mg flavored tablets (flavoring is poultry

liver, whey, garlic powder)
Pheromone, Dog Appeasing D.A.P.
USE: Appeasing pheromones are produced by the mother in the first

few days after she gives birth. The reassuring properties of the
appeasing pheromones persist throughout life. D.A.P. relieves
- 161 -
stress related behaviors by simulating natural dog appeasing

pheromones.
DOSE: Use in conjunction with other behavior modification practices as

directed by veterinarian.
FORMULA nON: 17 and 27 inch collars; electric diffuser (plug in);

601111 spray.
Phytonadione Vitamin Kl
USE: Treatment of anticoagulant-induced prothrombin deficiency;

hypoprothrombinemias due to interference ofK, absorption,
metabolism
DOSE: Dog, Cat: Warfarin intoxication: 2.5 mg/kg SQ initially, then

1.25 mg/kg SQ BID; SLOW IV infusion of 5 to 25 mg may be
waITanted if time is of importance and bleeding severe - not to
exceed a rate of 1 mg/minute
~£ond g~eratiQILanticoagulant rodenticide: 5 mglkg SQ

initially, then 5 mg/kg divided q8 to 12h for 2 weeks.
Post crisis maintenance: 0.25 to 2.5 mg/kg PO divided q8 to 12h

for 5 days in cases of warfarin intoxication and for 4 to 6 weeks
for second generation anticoagulant rodenticide.
Horse: 0.5 to 1 mg/kg q 4 to 6 h SQ. Do not administer IV

Cattle, Sheep, Goats, Swine: 0.5 to 2.5 mg/kg IM
FORMULA nON: 25 mg capsule (veterinary); 10 mg/ml in 1001111

multi dose vial
NOTE:
1. Rapid IV injection will cause anaphylaxis; give SQ using 25 g
needle.
2. FRESH WHOLE BLOOD IS INDICATED INITIALLY
WHEN BLEEDING IS LIFE THREATENING.
3. MEPHYTON is a trade name for the human phytonadione
- 162 -
Pilocarpine
USE: Topical use indicated for glaucoma, KCS. Oral use for KCS
only.
DOSE: 1 to 2 drops into eye q8 to 12h as needed. Place 2 drops of2%

(per 25 lb) onto food ql2h. Six drop maximmn.
Cats: place 1 drop of 0.5% solution onto food q 12h
FORMULATION: Pilocarpine 2% sterile ophthalmic solution, 15 ml

bottle with dropper tip.
Pimobendan VETMEDIN
USE: Approved for use in dogs, an inotropic drug with vasodilatative
properties. Pimobendan exerts a stimulatory myocardial effect
by inhibition of phosphodiesterase Type 3 and 5, and increasing
calcium sensitivity of cardiac myofilaments. Used for
congestive heart failure associated with myocardial failure.
DOSE: Dog: 0.2 to 0.3 mg/kg PO q12hrs
FORMULATION: 1.25 mg and 5 mg chewable tablet. Tablets are

capsule shaped and scored for splitting into halves.
Piroxicam
USE: Nonsteroidal anti-inflammatory
DOSE: Dog: 10 mg per large dog (over 50 pounds) PO QD for 3 days

Antitumor: 0.3 mglkg PO Q24H
- 163 -
NOTE: HUMAN PRODUCT. As with all NSAlDs, gastric ulceration.

platelet inhibition is a common complication; should only be
uscd intcm1ittcntly for pain rclicL.not for long tem1 use.
Poloxalene Drench THERABLOA T Drench Concentrate
USE: For the treatment oflegume (alfalfa, clover) bloat in cattle
DOSE: For oral use, prepare the drench as directed on label. For animal
up to 500 pounds usc 1 oz of concentrate, for animals over 500
pounds use 2 oz of concentrate
FORMULATION: 207 of drench concentrate -SPECIAL ORDER

ONLY
Polymyxin B Sulfate
USE: In the treatment of equine endotoxemia as in severe colic,

pleuropneumonia. metritis ... to bind endotoxin.
DOSE: Horse: 6000 u/kg IV gI2 to 24h as long as continued endotoxic

insult persists
FORMULATION: 500,000 units per vial for reconstitution
NOTE:
1. HUMAN PRODUCT.
2. Before reconstitution store at room temperature (below 86" F).
After reconstitution refrigerate and discard any remaining after
72 hours
Polymyxin B, Bacitracin Ointment DOUBLE ANTIBIOTIC

OINTMENT
Polymvxin B, Bacitracin, Neomycin Ointment TRIPLE
ANTIBIOTIC OINTMENT
USE: Antibiotic ointment for topical usc.
- 164 -
FORMULATION: Double available in 15 gram tube; triple in 30 gm

tube.
NOTE: HUMAN PRODUCT - available OTC
Polysulfated Glucosaminoglycan (PSGAG) ADEQUAN 1M,

ADEQUAN CANINE
USE: Intra-articular lubricant
DOSE: Horse: 250 mg intra-articularly once a week for 5 weeks or

500 mg to 750 mg 1M q4 to 7 days for 4 to 7 treatments
Dog: 2 mg/pound 1M twice a week
FORMULATION: ADEQUAN im 500 mg/5 ml vial

ADEQUAN CN 100mg/ml in MDV
Ponazuril15% MARQUIS Paste
USE: For treatment of equine protozoal myeloencephalitis (EPM)

caused by Sarcocystis neurona.
DOSE: Horse: 5 mg/kg PO once a day for 28 days.

For relapse ofEPM (excluding pregnant mares): potentially
effective - increase to 35 mg/kg/day for 4 doses (one tube of
paste for 500kg horse), then follow with standard 28-day course.
(ref Compendium Equines Jan/Feb 2008 pg 24)
FORMULATION: Available in pack of 4 tubes + plunger, each tube

should provide 7 doses for average adult horse
NOTE: In-patients may be dispensed I tube at a time
Potassium Bromide
- 165 -
USE: Experimental anti-convulsant therapy, used in conjunction with

phenobarbital or as sole anti-convulsant.
DOSE: Dog: with phenobarbital - 33 mg/kg PO QD, preferably given in

the evening. As sole anti-convulsant - 22 mg/kg PO Q12H
FORMULATION: Compounded in pharmacy to 250 mg/ml
NOTE:
1. ONL Y FOR DOGS IN WHICH ROUTINE
ANTICONVULSANT THERAPY IS INEFFECTIVE, requires
signature on release form.
2. A void contact with skin, mucus membranes.
3. Bromide levels should be checked at one month and again at 2
months. Any dosage adjustments should be done after the
second month levels. Serum levels should be between 1200 and
2000 mcg/ml (above 2000 mcg/mlleads to toxicity). See
Neurology Website for more infonnation.
Potassium Chloride Injection
USE: As a parenteral supplement to treat or prevent potassium

deficits. MUST DILUTE PRIOR TO IV/SQ
ADMINISTRATION.
DOSE: Dog,Cat: Add to fluids and administer at 0.05 -

0.5mEq/kg/hour
Horse: 45 mEq per 5 liters of fluid
FORMULA TION: 60 mEq/30 m! vial
NOTE: Maximum rate not 10 exceed 0.5 mEq/kg/hr.
Potassium Gluconatc TUMIL K
USE: As an oral supplement in potassium deficient states in dogs and

cats.
. 166 -
University of FloridL ...................................... Veterinary Medical Center
DOSE: Dog, Cat (Adult): t;;, level teaspoonful of powder or Yo

teaspoonful of gel or I tablet per 10 pound (4.5 kg) BID with
food. Dosage may be adjusted to satisfy patient's need.
FORMULATION: 2 mEq (468mg) pertablet; 5 02 tube of gel for PO.

SPECIAL ORDER ONLY: 4 02 powder, 2 mEl}
(468mg) per level y" teaspoonful.
Degree of Dose of KCI to infuse I

Hypokalemia Semm K + mEq/L slowly IV over 24 hours
Mild 3.0 to 3.5 mEq/L I to 3 mEq,q'g I
Moderate 2.5 to 3.0 mEq/L 3 to 5 l11Eq/kg
Severe <2.5l11EQ/L 5 to 10 l11Eq/kg
NOTE:
1. Do not administer in diseases where high potassium levels may
be encollntered sllch as severe renal insufficiency Of adrenal
insufficiency.
Use with caution in prcscnce of cardiac disease, particularly in
digitalized patients or in the presence of renal disease.
Potassium Phosphate Injection
USE: In fluid therapy, to treat or prcvcnt hypophosphatemia
FORMULATION: Each ml contains equivalent to phosphorous 93 l11g

or 3mM; potassium 170 mg or 4.4 mEq; in 5 ml
single-dose vial.
Povidone-Iodine
USE: Topical antibacterial
FORMULATION: Ointment ~c 1% available iodine; in 1 oz. tube, 4 02

jar. Solution = I '% available iodine, dispensed by
the ml, oz.
- 167 -
University of Florida "','" .. ,", .. " ...... ".,."., ....... ' Veterinary Medical Center
NOTE: May be bandaged over.
Pralidoxime Chloride 2-PAM, PROTOPAM
USE: Antidote for poisoning due to organophosphate pesticides and

other chemicals with anticholinesterase activity. Releases bound
acetylcholinesterase.
DOSE: Dogs, Cats: 20 mg/kg IV over 2 minutes q8 to 12h until all

evidence of poisoning disappears, Should be used
in conjunction with atropine,
Horse: 20 mg/kg rv q4 to 6h
FORMULATION: 1 gram vials (powder to be reconstituted) -

SPECIAL ORDER
NOTE:
1. IV Injection should be given slowly, Rapid injection can cause
death,
2, Not recommended for carbamate intoxication.
Pramoxine 1%, Novasome microvesicles DERMAL SOOTHE Spray
USE: Designed to provide itch relief, lasting moisture and coat luster.
DOSE: Spray liberally onto damp or dry coat, allowing spray to reach
the skin, repeat as needed. Wear mbber gloves when applying,
FORMULATION: 12 oz spray
Pramoxinc Hydrochloride 1 %, Colloidal Oatmeal DERMAL

SOOTHE SHAMPOO
USE: To provide rapid and prolonged relief ofpruritus in dogs and

cats.
- 168 -
DOSE: Dog, Cat: Shampoo, rinse, while still wet apply creme rinse
liberally and work in well, allow 5 to 10 minutes contact time,
rinse well, repeat as needed. Wear rubber gloves when applying
FORMULATION: Shampoo 8 oz.
Praziguantel DRONCIT
USE: Cestocide for removal of Dipylidium eaninum, Taenia

pisiformis and Echinococcus from dogs and Dipylidium
caninum and Taenia taeniae formis from cats.
species Tablet weight Dose

Dog 34mg < 5lb Yz tablet
6 -10 Ib 1 tablet
11-15Ib 1 Yz tablets
16 - 30 Ib 2 tablets
31-451b 3 tablets
46 -60 Ib 4 tablets
> 60 Ib 5 tabs (max)
Cat 23 mg <41b Yz tablet
5 - llib 1 tablet
> 11 Ib 1 Yz tabs (max)
Injectable weight Dose
Dog 56.8 mg/ml < 51b 0.3 ml
6 -10 Ib 0.5ml
11-25Ib 1.0 ml
> 251b 0.2 ml/Slb
Max = 3 ml
Cat <51b 0.2 ml
5 -10 Ib OAml
> 10 Ib 0.6 ml
Max = 0.6 ml
Cats: Liver Flukes: 20 mg/kg PO once daily for 3 days

Reptiles: Trematodes: 8 mg/kg 1M or PO, repeat in 2 weeks
FORMULATION: CANINE, 34 mg scored tablet
- 169 -
FELINE, 23 mg scored tablet

INJECTION, 56.8 mg/ml (may appear slightly
pink - OK to use)
NOTE: NOT f()r puppics < 4 weeks or kittens < 6 weeks
Pl'ednisolone
USE: For sterile inflammation and immune-mediated diseases
DOSE: Dog: 0.5 to 1 mg/kg PO QD; 2.2 mg/kg PO QD as

immunosuppressant
Cat: 0.5 to 2 mg/kg PO QD; 2.2 to 6.6 mg/kg PO QD as an
immunosuppressant
Horse: 0.5 to 1.0 mg/kg PO or 1M QD
FORMULATION: 5 mg scored tablet. I\lso as prednisolone sodium

phosphate 15 mg/5 ml- alcohol-free, dye-free, oral
solution
Prednisolone Acetate 1%
USE: Topical corticosteroid for use in the eye.
DOSE: 1 drop QID.
FORMULATION: 1% ophthalmic suspension (SHAKE WELL) in

10011 bottle with dropper tip.
CONTRATNDICATION: Corneal ulceration
NOTE: HUMAN PRODUCT
Prednisolone Sodium Succinate SOLU-DELTA-CORTEF
US E: Glucocorticoid use in treatment of shock and acute

hypersensitivity reactions.
- 170 -
DOSE: Dog, Cat: SHOCK: 5 to 10 mg/kg IV as initial dose.

Acute Hypersensitivity: 1 to 2 mg/kg IV as initial dose
Horse: 2 to 4 mg/kg IV
FORMULATION: 100 mg, 500 mg ACT -0- VIAL (single dose)
NOTE: Solutions should be used immediately after mixing, but solution

stable for 48 hours after mixing if refrigerated - before using a
stored solution be sure solution is clear of particulates and has
not undergone a color change, if so discard.
Prednisone
USE: Antineoplastic agent, immunosuppressive agent, anti-

inflammatory agent
DOSE: Dog: Antineoplastic and immunosuppressive: 1 to 4 mg/lb PO

QD for 21 days, then q2days thereafter. Anti-
inflammatory: 0.25 mg/lb PO QD.
Cat: Antineoplastic and immunosuppressive: 1 to 3 mg/lb PO
QD. Anti-inf1ammatory: 0.25 mg!lb PO QD.
Horse: 0.02 to 4.4 mg/kg PO q 12 to 24h. Immunosuppressive
dose: 2 mg/kg PO QD
FORMULATION: J mg,5 mg, 20 mg, and 50 mg tablets (other

strengths are manufactured)
CONTRAINDICA TIONS: Severe bacterial or fungal infection.
TOXICITIES: Pancreatitis, diarrhea and Cushingoid state with

chronic administration.
-----_._---_._----------
PREPARATION H
USE: To aid in the healing of decubital ulcers and open wounds;

reported benefits may include increased tissue oxygen
- 171
consumption, increased collagen production, mild antibacterial

properties, stimulation of granulation tissue.
DOSE: Topically
FORMULA TION: I oz tube of ointment containing: mineral oil,

petrolatum, phenylephrine, shark liver oil
NOTE: HUMAN PRODUCT, available OTC
Procainarnide HCL
USE: Ventricular arrhythmias
DOSE: Dog: Ventricular tachycardia: 6 to 15 mg/kg IV over 5 minutes,

then give by constant rate infusion at 25-40 mcg/kg/min or
6 to 20 mg/kg 1M q 4 to 6h
Maintenance: 8 to 20 mg/kg PO q6h for regular tablets or
q8h if extended release tablets are used.
Horse: I mg/kg/minute IV to a maximum of 20 mg/kg
FORMULA nON: 100 mg/ml injection in 10 ml multidose vial.
Proparacaine HCL 0.5%
USE: Topical, ophthalmic anesthetic. For diagnostic use only.
FORMULA nON: 15 ml bottle with dropper tip SPECIAL ORDER
NOTE:
l. Delays corneal wound healing.
2. Store at 46° to 75°F before opening, store at 35° to 46° F after
opening.
3. Protect from light.
4. Do not use if solution is more than faint yellow.
172 -
University of Florida ................... ,........ ,.......... Veterinary Medical Center
Propofol PROPOFLO
USE: A hypnotic agent used in the induction and maintenance of

anesthesia
DOSE: This product should only be used by persons Imowledgeable in

the administration of general anesthesia. Facilities for
maintenance of patent airway, artificial ventilation, and oxygen
enrichment and circulatory resuscitation must be immediately
available.
FORMULATION: 10 mg/ml emulsion, 20 ml single dose vial.

Contains no preservative, contents of vial for
single patient use only; any remaining MUST BE
DISCARDED.
Propranolol
USE: Non-selective f31 and 132 adrenergic blocking agent. Class II

antiarrhythmic drug (~-blocker), especially for supraventricular
and stress-induced (catecholamine) alThythmias. As
cardioprotective with feline hyperthyroidism and hypertrophic
cardiomyopathy.
DOSE: Dog: I to 3 mg SLOWLY IV; 0.5 to I (2) mg/kg TID

maintemmce, titrate to effect.
Cat: 2.5 to 5 mg TID
For detrusor atony: Dog, Cat: 0.25 to O.S mg/kg PO TID
Horse 0.38 to 0.78 mg/kg PO q8h; or O.OS to O.I 6 mg/kg IV
gl2h
FORMULATION: 1 mg/ml injection in I ml single dose vial
SIDE EFFECTS: Bradycardia, AV -blocks, weakness, decreased cardiac

contractility, bronchospasm, GI-upset
CONTRAINDICATlONS: Congestive heart failure, high grade AV-

blocks, severe bradycardia, asthma,
hypoglycemia
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NOTE: Reduce the dose with liver disease. High doses can cause
depression and lethargy.
Propylene Glycol
USE: 1. As a glucogenic agent in the treatment of ketosis.

2. As a dermatologic agent:
a. For desquamation of horny layer of skin. Dilute to
30-40% with water.
b. As an antibacterial and antifungal agent. Dilute to
40-50% with water.
DOSE: Cow (for ketosis): 225 g (8 oz) BID for 2 days then 110 g (4
oz) BID for 2 days.
For dermatologic use: Apply as directed. Consult
Dermatologist.
FORMULATION: 160z
ADVERSE EFFECTS: Diarrhea, decreased rumen motility. Prolonged

use can result in devitalization of rumen
micro flora. Do not use topically in cats:
ingestion may cause Heinz body formation.
Protamine Sulfate
USE: Treatment of heparin overdose.
DOSE: 1 mg/lOO USP units of heparin by SLOW IV infusion.
FORMULA TION: 250 mg/25ml single dose vial
NOTE:
1. This drug is used to counter bleeding caused by heparin
overdose.
2. Do NOT exceed 50 mg/l 0 minutes.
- 174-
3. Blood or plasma transfusions may be necessary to dilute

heparin.
4. Do NOT mix in solutions containing cephalosporins penicillin.
5. Since heparin is cleared rapidly from the circulation, the dose of
protamine S04 required also decreases rapidly with the time
lapse following IV heparin injection. Example, if the protamine
S04 is administered 30 minutes after the heparin, one-half of
the usual dose may be sufficient.
6. HUMAN PRODUCT
7. Can cause anaphylaxis
Psyllium Hydrophilic Muciloid Powder KONSYL
USE: Bulk laxative, useful in control of both diarrhea and

constipation.
DOSE: Dog: Mix 1 teaspoonful to 2 tablespoonfuls with food ql2 to

24h.
Horse: 1 g/kg q12 to 24h; for prevention use 1 g/kg PO q24h
for 1 week per month. Use with extreme caution in
painful animals, especially if a complete large
intestinal obstruction has not been ruled out.
FORMULATION: KONSYL -15.9 oz (450g) bottle, sugar free;

provides per rounded teaspoonful 6g of 100%
natural psyllium hydrophilic mucilloid (equal to 4
g of soluble fiber).
Pyrantel Pamoate STRONGID T
USE: Anthelmintic effective against roundworms, hookworms; not

effective against whipworms.
DOSE: Dog and Cat: 5 to 22 mg/kg PO repeat in 21 days.

Horse: 6.6 mg/kg orally; 13.2 mg/kg PO for tapeworms
Psittacines, Doves: 5 mg/kg; repeat in 21 days
FORMULATION: 50 mg/ml oral suspension, yellow
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Pyridostigmine MESTINON
USE: Anticholinesterase use to control myasthenia gravis.
DOSE: Dog: 0.5 to 2 m1 per day

Cat: 0.25 to 1 ml per day
FORMULATION: 12 mg/ml oral syrup (raspberry flavored) alcohol

5%. 60 mg tablet- we do not stock
NOTE:
1. Atropine is an antidote.
')
"-. Extcmporaneously compounded product should 110t be made
with methylcellulose vehicle as this will inhibit drug absorption
(per NCSU).
Pyrimethamine DARAPRIM
lJSE: Folic acid antagonists used in the treatment of toxoplasma, and

Equine Protozoal Myeloencephalitis.
DOSE: Dog, Cat: 0.5 to 1 mg/kg PO QD for 3 days then 0.5 mg/kg
PO QD (in combination with oral TMP-Sulfa)
Horse: 2 mg/kg PO QD for 7 days then 1 mg/kg PO QD
FORMULA TION: 25 mg scored tablet
NOTE:
1. Can cause bone marrow suppression.
2. Must be given on an empty stomach - I hour minimum before
and 2 hours after green hay; can feed with brown hay, grain due
to lower folic acid content.
Pyriproxyfen, Tetramethrin Area Treatment KNOCKOUT AREA

TREATMENT
- 176 -
USE: A flea spray for use on carpets, drapes, upholstery, pet bedding;
kills both adult and pre-adult fleas, also kills ticks.
DOSE: A fine mist applied uniformly 2 to 3 feet from surfaces.
FORMULATION: 14 oz aerosol can
Pythium Insidiosum Allergenic Extract
USE: Immunotherapy for the treatment ofPythium insidiosum

infection.
DOSE: Iml SQ on Day 1; I ml SQ on Day 7; 1 ml SQ on Day 21
FORMULATION: An aqueous extract 0.2mg/ml (USDA Biologic

#9540), 3ml per vial SPECIAL ORDER
NOTE: Observe animal for 30 minutes after injection.
Quinapril
USE: Angiotensin Converting Enzyme (ACE) inhibitor. Quinapril is

metablolized to the active metabolite, quinaprilat. Indicated for
the treatment of hypertension.
DOSE: Horses: 120 mg/horse.
Quinidine
USE: Antiarrthymic drug, class IA; for supraventricular as well as

ventricular arrhythmias; for conversion of atrial fibrillation to
sinus rhythm in selected cases.
DOSE: Dog: 6 to 20 mg/kg q6 to I2h PO or 1M as maintenance dose.

IV quinidine is very hypotensive and should be avoided.
- 177 -
Horse: Sulfate: 22 mg/kg via nasogastric tube q2h up to total

of 6 doses or until signs of toxicity develop. Must usc
NG tube - do not give orally. Gluconate: 0.5 to 2.2
mg/kg TV q 10 minutes up to a total dose of 12 mg/kg
STDE EFFECTS: Nausea, anorexia, vomiting, diarrhea, seizures, nasal

edema in horses. ECG: widening of the QRS,
prolongation of the PR-interval, new aIrhythmias.
DRUG INTERACTIONS: CIMETIDINE reduces quinidine absorption

and elimination. Quinidine raises serum
DIGOXIN levels. There may be additive
effects of quinidine with anticholinergics.
Reduced quinidine plasma levels may result
from HEPATIC ENZYME INDUCING
DRUGS.
CONTRAINDICATIONS: Idiosyncrasy or hypersensitivity to

quinidine, complete AV -block, arrhythmias
secondary to digitalis- intoxication,
myasthenia gravis
FORMULA nON: Quinidine sulfate 200 mg; Quinidine gluconate 80

mg/ml inj in 10 ml vial- SPECIAL ORDER
NOTE: Reduce dose with liver disease, CHF, hypoalbuminemia.
Ranitidine ZANTAC, generic
USE: H2 blocker
DOSE: Dog, Cat: 2 mg/kg BID, PO, IV

Horse: 4.4 to 6.6 mg/kg TID PO; 1 to 2 mg/kg IV TID
FORMULA TION: 150 mg tablet; 15 mg/ml oral syrup; 25 mg/ml, 40

rn! vial
NOTE: The drug has a greater affinity for H2 receptors than cimetidinc
and needs only BID dosage (in dog, cat).
- 178 -
Remifentanil UL TIVA
USE: A mu opiod agonist with rapid onset and peale effect, and shori
duration. Useful in perioperative and postoperative analgesia.
Eliminated via non-specific bUod and tissue esterases. Useful in
patients with impaired metabolism, rapidly eliminated.
DOSE: Dog: For anesthesia: 0.1 to 2 mcg/kg/min

For pain: 1-5 mcg/kg/hour
FORMULATION: 1 mg vial as powder for reconstitution.

Reconstitute with Iml, then further dilute to 20,
25,50, or 250 mcg/ml prior to administration.
*Recommendation is to reconstitute to 50mcg/ml.
Note: HUMAN PRODUCT, CII controlled substance
Reserpine
USE: Anti-adrenergic agent, to stimulate milk production in mares
DOSE: Horse: 2.5 mg PO QD for 7 to 60 days.
FORMULATION: 0.25 mg tablets - special order product.
NOTE: HUMAN PRODUCT
Rifampin
USE: Antibiotic with broad antibacterial spectrum
DOSE: Horse: 5 mg/kg PO q12h
FORMULATION: 300 mg capsules
NOTE:
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University of Florida ........ " .............................. Veterinary Medical Ccnter
1. HUMAN PRODUCT.
2. Capsule contents will discolor skin. Wear Rubber Gloves.
3. Will discolor urine, sweat, saliva, vomit, feces orange/Red
Romitidine HC) SEDIVET
USE: An alpha-2-adrenoreceptor agonist, sedative and analgesic

properties
DOSE: Horse: Sedation and analgesia: SLOW IV, 40 to 120 mcg/kg.

Onset in 30 seconds to 5 minutes, duration 2-4 hours.
FORMULATION: 10 mg/ml for injection
NOTE: Duration of analgesia is shorter than duration of sedation.

Solution will precipitate with other drugs in syringe.
Salicylic Acid, Aloe Vera, DSS SWEET PEA & VANILLA EAR
CLEANSER
USE: An otic cleanser designed to clean, dry, acidity and deodorize the
ear canal.
DOSE: Apply liberally into ear canal. Massage base of ear. Allow to
shake head. Remove excess with cotton ball. Use 2-3 times daily
for excessively dirty cars. Use 1-2 times weekly to maintain
healthy ears.
FORMULATION: 8 oz squeeze bottle
Salmeterol xinafoate SEREVENT Inhalation Aerosol
USE: A long-acting ~"l-adrenergic agonist selective for B-2 receptors;

jClt' use
in severe bronchospasm that is poorly responsive to
short- acting ~-2 agonists.
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University of Florida ..... ,.... ,............................. Veterinary Medical Center
DOSE: Horse: 1 actuation per 50 kg twice daily, by Equine Aeromask
FORMULATION: Each canister (13 g) provides 120 metered

actuations - SPECIAL ORDER
NOTE:
1. HUMAN PRODUCT
2. Shake canister well before using
3. Use only with the Serevent adapter
4. Do not use more frequently than 2 times a day
5. Do not use to relieve sudden asthma symptoms
SAMe DENOSYL SD4, s-adenosylmethionine
USE: A nutraceutical. "Recommended to improve hepatic glutathione

levels in compromised patients to help maintain and protect
liver function."
DOSE: Dog, Cat: 18 mg/kg of body weight PO daily, may be divided.

Round dosage to the nearest whole tablet. Give on
an empty stomach, at least one hour before feeding.
FORMULATION: Enteric coated tablets, 90 mg, 225 mg, and 425

mg. Do not cut or crush the tablet. Tablets are
moisture sensitive - do not remove from blister
pack until ready to administer.
Selamectin REVOLUTION
USE: A semi-synthetic avermectin, applied topically to dogs and cats,

effective against internal and exterual parasites
DOSE: Dogs, cats: Dosage range is 6 mg/kg to 12 mg/kg; may be used

on dogs and cats 6 weeks of age and older
Dog Weight Dose

Up to SIb 15 mg tube (mauve)
5.1-10Ib 30 mg tube (purple)
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I 10.1 - I 60 mg tube (brown) ~

("dL-""L
20 lb
20.1 - 40 lb
120 mg lub,
I 40.1 - 851b 240 mg tube (teal)
85 - 130 Ib 240mg + 120mg (combo)
Cat Weight
Up to 5 lb 15 mg tube (mauve)
5.1 - 15 Ib 45 mg tube (blue)
Over 15 Ib use combination of tubes
FORMULATION: See above; colors indicate packaging color. There

are two different strength solutions of selameetin,
60 mg/ml and 120 mg/ml; the mauve pack comes
with 3 tubes all others come with 6 tubes. May
purchase by the individual dose or by the pack.
NOTE:
1. Use with caution in sick, debilitated, or underweight animals.
2. Safe for brecding males and females, as well as pregnant and
lactating females.
3. Stiff hair, clumping of hair, hair discoloration, or powdery
residue may be seen. These effects are temporary and do not
alIecl safety of effectiveness.
4. May divide total volume (large dogs) over 2 spots.
5. Only cffcctivc against Dermacentor variabilis.
6. May be used in ivermectin-sensitive collies.
7. May be used in heartworm positive dogs and cats.
8. Wait 48 hours after applying Advantage, Frontline Spray or
Frontline Plus before applying Revolution.
9. For tick problems - PREVENTIC (amitraz) collars available for
dogs at no charge.
SeJegiline hydrochloride ANIPRYL
USE: A MAO inhibitor, approved for control of signs of canine

cognitive dysfunction (CDS) and control of uncomplicated
canine pituitary dependent hyperadrenocorticism (PDH). It is
also used for cognitive dysfunction in eats (not FDA approved).
DOSE: Dog: 0.5 mg/kg to I mg/kg PO once daily in the morning.
- 182 -
Cat: 0.5 mg/ml to 1 mg/kg PO once daily in the morning.
FORMULATION: 10 mg, 15 mg, 30 mg tablets - check for

availability
NOTE:
1. Review literature and insert - serious drug interactions and
contraindications
2. Safe use in breeding males and females, and pregnantand
lactating females has not been established.
Do not use for treatment of other behavioral problems.
- - - - - - - - - - - - - - - - - - - - - - - - _....._ - -
Sevoflurane SEVOFLO
USE: An inhalation anesthetic, for induction and maintenance of

general anesthesia; providing quicker induction and recovery
when compared to isoflurane
DOSE: Dog: MAC 2.1 to 2.4%

Cat: MAC 2.6%
FORMULA nON: 250 ml
Sildcnafil
USE: Phosphodiesterase Type 5 inhibitor. Used for vasodilation of

pulmonary arteries with pulmonary hypertension.
DOSE: Dog: 2 to 3 mg/kg PO qg to 12hrs
FORMULATION: 100mg; also, can be compounded into suspension

from tablets 2.5 mg/mI, expires after 90 days
NOTE: Monitor blood pressure
Silver Sulfadiazine 1'l{, cream SILV ADENE, generic
- 183 -
USE: Topical antimicrobial
FORMULATION: 1% silver sulfadiazine available in 50 gram jars;

1000 gram jars are available by special order.
NOTE: HUMAN PRODUCT
Sodium Bicarbonate
USE: 1. To correct metabolic acidosis.

2. To alkalinize the ECF and urine.
3. Adjunct treatment in hyperkalemia
DOSE: Acidemia due to metabolic acidosis: (pH <7.2)

Blood gases available:
mEq HC03 = 0.3 x base deficit x BW(kg) IV
(give half over 5 minutes and remainder over next 3 to 4 hours)
Blood gases unavailable:

2 to 4 mEq/kg IV over 3 to 4 hours
Metabolic alkalosis of chronic renal failure and to alkalinize the

unne:
8 to 12 mEq/kg PO TID
(adjust dose to achieve TC02 > 18 mEq/L)
FORMULATION: 8.4% injection in 50 ml vial (l mEq/ml)
NOTE:
1. Rapid administration can induce seizures (hypocalcemia and
paradoxical CNS acidosis
2. Excessive administration can cause fatal alkalemia.
3. Care with CHF due to high sodium level.
4. Avoid mixing with Ca++ containing solutions (includes Ringer's
solutions).
5. Can promote hypokalemia.
6. Never administer a bolus of7.5 - 8% IV push to any animal
less than 1 to 3 kg this will cause acute hypertonic (hyperNa)
- 184 -
encephalopathy, tearing the pia mater vessels causing diffuse

hemorrhage.
1 gram NaHC03 = 11.9 mEq sodium and 11.9 mEq bicarbonate

Isotonic NaHC03 = 13.75 gil
8.4% NaHC03 = 1 mEq/ml
Sodium Chloride 5% Ophthalmic MURO 128
USE: Hypertonic ophthalmic product for corneal edema.
DOSE: Place a thin film into affected eye(s) a minimum of q24h to help
alleviate corneal edema; QlD required for severe corneal edema.
FORMULATION: Sterile solution, 15 ml bottle with dropper tip;

sterile ointment, 3.5 gram tube
NOTE:
1. HUMAN PRODUCT.
2. Brand name preferred over generics.
Sodium Chloride
FORMULATION: 0.9% injection in 10 ml vial, preservative free.
NOTE: See also Parenteral Fluids in Appendix.
Sodium Citrate 4%
USE: Anticoagulant for use in intra-articular infusion pumps blocks

coagulation by chelating calcium.
FORMULATION: 250 ml bag - SPECIAL ORDER
NOTE: NOT FOR DIRECT INFUSION
- 185 -
Sodium Hypochlorite, Sodium Thisulfate SURFACE SAFE
USE: A product used to clean and inactivate most anti-cancer drugs

form inert surfaces (floors, counter tops, etc).
FORMULATION: Contains sodium hypochlorite (Packet No.1) and

sodium thiosulfate (Packet No.2). Carefully read
instructions for proper use and disposal of used
towelettes.
Sodium Iodide 20%
USE: Treatment of actinomycosis and actinobacillosis in cattle, sheep

and as an expectorant.
DOSE: 30 mg/pound, may repeat at weekly intervals, give slowly IV.
NOTE: Not for use in lactating dairy animals.
Sotalol HCI
USE: A P-blocker used in the treatment of atrial and ventricular

arrhythmias.
DOSE: Dog: 1 to 3 mg/kg PO BID
Spino sad COMFORTIS
USE: Indicated for the prevention and treatment of flea infestations

(Ctenocephalides felis) on dogs.
- 186-
DOSE: Chewable tablets are fonnulated to provide a minimum dose of

30 mg/kg (13.5 mg/lb). Administer weight appropriate dose by
mouth once a month, preferably with a meal.
FORMULATION: 6 tablets per box. May buy tablets by the each.
140mg 5 to 10 pounds
270mg 10.1 to 20 pounds
Combination of tabs over 120 pounds
NOTE:
1. Administer with food for maximum effectiveness
2. If vomiting occurs within 1 hour of administration - redose
with a full dose. Can avoid vomiting by giving Yo dose in
morning and 'l2 dose in evening.
3. If a dose is missed - administer dose with food and resume
monthly schedule.
4. Use only in dogs 14 weeks and older, use with caution in
breeding females, safety in breeding males has not been
established.
5. The spino sad milk: reference plasma exposure ratio
calculated from a pilot study (refer to insert) ranged from
2.2 to 3.5.
6. Starts killing fleas in 30 minutes.
7. Kills fleas before they can lay eggs.
8. For dogs ONLY.
9. Avoid using in dogs on high doses of ivennection.
Concurrent use of spinosad in dogs on iverrnection doses
for demodectic mange has been reported to result in mild
to moderate ivennection toxicity.
Spironolactone
USE: 1. An aldosterone competitive antagonist used as a weak

diuretic usually used in conjunction with other more powerful,
potassium wasting diuretics because spironolactone prevents
- 187 -
University of Florida ....... ., .............. ., ............... Veterinary Medical Center
potassium loss. May be important in liver disease when

hypokalemia may sustain metabolic alkalosis. Most useful as a
diuretic in hyperaldosteronemic states. e.g. congestive heart
failures, nephrotic syndrome.
2. Hirsutism
DOSE: Dog, Cat: I to 2 mg/kg PO qI2 to 24h
NOTE: Blocks testosterone effect and has weak estrogen activity.

Combine use with K+ supplementation may induce
hyperkalemia, particularly in patients with reduced renal
function.
Stannous Fluoride 0.4% MEDEQUINE TOPICAL SPRA Y
USE: Topical therapy for susceptible bacterial infections unresponsive

to systemic therapy. For use dogs and horses. To be used as a
substitute for systemic antibiotic therapy for MRSA skin
infections.
DOSE: Spray a liberal amount topically onto affected areas twice daily
for 3 to 4 weeks or until affected area shows signs of good
health.
FORMULA nON: 22 oz. bottle contains Glycerin, Purified water, Zinc

gluconate, Stannous fluoride.
Sucralfate CARAFA TE, generic
USE: For use in the treatment of gastrointestinal tract ulceration,

usually in combination with an H2 antagonist.
DOSE: Dogs, Cats: Under 20 kg: give 500 mg PO q6h on an empty

stomach. Over 20 kg: give 1 gram PO '16h on an
empty stomach
- 188 -
Horse: 20 to 40 mg/kg PO TID to QID
FORMULATION: 1 gram scored tablet; 100 mg/ml oral suspension
NOTE:
1. HUMAN PRODUCT
2. Sucralfate may potentially bind to some extent with syrup, use
water only to dissolve tablets into slurry prior to administration.
Sulfadiazine, Pyrimethamine REBALANCE
USE: Antibacterial combination product for the treatment of EPM.
DOSE: 4 ml per 50 kg by mouth once daily (20 mg/kg sulfadiazine and

1 mg/kg pyrimethamine); duration oftreatment ranges from 90
to 270 days. Administer at least 1 hour before feeding hay or
grain.
FORMULATION: Oral suspension provides sulfadiazine 250mg/ml

and pyrimethamine 12.5mg/ml- check for
availability - as of April 2007 product
UNAVAILABLE FROM MANUFACTURER.
Sulfadimethoxine ALBON
USE: A long-acting sulfonamide used in the treatment of coccidiosis.
DOSE: Dogs, Cats: 50 mg/kg PO on day 1, then 25 mg/kg QD for 5 to

20 days until symptoms disappear OR 55 mg/kg IV
loading dose, then 27.5 mg/kg once daily; For CNS
infections: 15 mg\kg BID
FORMULATION: 125 mg tablets; 50 mg/ml oral suspension
Sulfadimethoxine, Ormetoprim PRIMOR
- 189 -
University of Florida ......................... ., .. ., ......... Veterinary Medical Centcr
USE: A potcntiated sulfonamide antibiotic, for the treatment of

susceptible skin and soft tissue infections in dogs.
DOSE: Dog: First day dose at 55 mg/kg (25 mg/lb) PO QD, then
dccrcasc to 27.5 mg/kg (12.5 mg/lb) PO QD.
FORMULATION: 1200 mg tablet = 1000 mg sulfadimethoxine, 200

mg ormetoprim;
600 mg tablet = 500 mg sulfadimethoxine, 100 mg
orl11etoprim;
240 mg tablct = 200 l11g sulfadil11ethoxitlc, 40 mg
ormetoprim;
120 mg tablet = 100 mg sulfadimethoxine, 20 mg
ormetoprim.
NOTE:
1. Manufacturer suggests to continue treatment for at lcast 2 days
after absence of clinical signs, but no longer than 21 consecutive
days
2. Safety in breeding dogs not established.
3. Do not use in dogs with signs of parenchymal damage, blood
dyscrasias, or history of sulfonamide hypersensitivity
Sulfasalazine
USE: In the treatment of colitis and proctitis in both dogs and cats.
DOSE: Dogs: 20 to 30 mg/kg PO qRh

Cats: 20 mg/kg PO ql2 to 24h
NOTE:
I. Cats metabolize more slowly so a lower dose is required. In cats
watch for anorexia. If this occurs stop administration for 24
hours and change to QOD therapy. Do NOT use for longer than
30 days in dogs or cats.
2. Can cause keratoconjunctivitis sicca.
3. Will STAIN.
- 190 -
Taurine
USE: Nutritional requirement of cats
DOSE: Cat: 125 mg/day
FORMULATION: Crystalline, 99%; to be added to enteral diets
Terbutaline BRETHINE
USE: Bronchodilator, beta-agonist; also used in equine intradermal

sweat test
DOSE: Dog: 0.625 mgll 0 pound PO q8h

Cat: 1.25 mg PO ql2
For acute asthma: 0.01 mg/kg SQ or 1M
FORMULATION: 5 mg tablets, 1 mg/J ml vial
Tetracyc!ine HCLPANMYCIN, generic
USE: Bacteriostatic agent
DOSE: Dogs, Cats: 20 mg/kg PO q8h

Psittacines: 50 mg/kg PO TID for Mycoplasma, (second drug
of choice for chlamydiosis.
Cattle, sheep: 11 mg/kg PO BID for up to 5 days.
Swine: 22 mg/kg PO daily in water.
FORMULATION: Capsules, 250 mg, 500 mg.
NOTE:
1. NEVER USE EXPIRED TETRACYCLINE: NEPHROTOXIC
2. Commonly causes vomiting in cats.
3. Can cause high fever in cats.
- 191 -
CONTRAINDICATIONS: NOT for use in young animals. Not to be

given with calcium containing products.
Theophvlline anhydrous
USE: A xanthine derivative indicated for symptomatic relief or

prevention of bronchial asthma, reversible bronchospasm
associated with chronic bronchitis, pneumonia.
DOSE: Dog: 20 mg/kg PO q12h

Cat: 25 mg/kg PO q24h
FORMULATION: 200 mg tablet, extended release
NOTE: Therapeutic blood level for dog: 10 - 20 mcg/mt. Numerous

drugs interact with theophylline - check! Inform owner of signs
of overdosage.
Thiabendazole, Dexamethasone, Neomycin Sulfate TR]<;SADERM
USE: Treatment of bacterial, mycotic, and inflammatOlY dennatoses;

otitis extern a in dogs and cats.
DOSE: Dog, Cat: 5 to 15 drops in ear BID

For dermatoses: 2 to 5 drops per square inch BID.
FORMULA nON: 7.5 ml and J 5 ml bottles with dropper tip; STORE

TN REFRIGERATOR-dexamethasone loses 1%
efficacy per day at 1200 (per MSD)
NOTE: Manufacturer recommends that treatment should not exceed 7

consecutive days, however some clinicians may use for 10 to 14
days or treat for 7 Of 10 days, stop fix 7 or 10 days, then repeat
treatment for 7 or I 0 days.
Thiamine HCI Vitamin HI
- 192 -
USE: Vitamin Supplement
DOSE: Cats: 50 to 100 mg 1M once initially, then 50 mg 1M QD.

Raptors, Psittacines: 1 to 2 mg/kg 1M, PO once daily. Do not
exceed 100 mg total dose, can cause encephalitis.
FORMULATION: 200 mg/ml
NOTE: Painful 1M injection. Do not give by IV push.
Thiopental Sodium PENTOTHAL
USE: Ultra short-acting barbiturate for anesthesia; C-IJI controlled

substance
DOSE: Dogs, Cats: 13.2 to 26.4 mg/kg IV (from package insert)

Horse: 6 to 12 mg/kg IV with pre-anesthetic tranquilization.
Cattle: 8 to 11 mg/kg IV after sedation; calves less than 2
weeks of age: 15 to 20 mg/kg slowly to effect
FORMULATION: 1 gram vial
Ticarcillin, clavulanate potassium
USE: An extended spectrum penicillin anti biotic requested as an

alternative to polymyxinB for topical treatment of psuedomonas
in the ear.
DOSE: Dog: Otitis externa: O.Sml of prepared solution in each ear BID
FO RMULA TION: 3g bottle, as powder for reconstitution
Directions for mixing:

1. Add 13ml of sterile water or 0.9% saline for injection to
make concentrate - stable for 6 hrs at room temp or 72 hrs
in refrigerator
- 193 -
2. Further dilute to 10mg/mi up to 100mg/ml with LRS, 5%

dextrose or 0.9% saline- stable for 24 hrs at room temp or
7 days in refrigerator, or 30 days frozen
3. Thaw frozen solution in refrigerator or at room temp - DO
NOT use microwave or water bath. Do not refreeze.
Discard thawed solution after 24 hours at room temp or 7
days in refrigerator.
4. If 5% Dextrose is used to prepare solutions, the life span is
shorter - 24 hours at room temp, 3 days in refrigerator or 7
days tj'ozen.
NOTE:
1. HUMAN PRODUCT
2. Stop other solutions during infusion. Do not mix in same.
IV solution with sodium bicarbonate, gentamicin,
a111ikacin, or tobramycin
Tiletamine, Zolazepam TELAZOL
USE: Non-narcotic, non-barbiturate, injectable anesthetic agent;

primarily used in exotic species.
DOSE: Variable; carnivores 4 mglkg.
FORMULATION: After reconstitution each 51111 vial provides 250

mg tiletamine and 250 mg zolazepam; solution
may be stored at room temperature for 4 days or
refrigerated for 14 day&. Solution may vary from
colorless to light amber.
NOTE: C-III controlled substance
Timolol TIMOPTIC, generic
USE: B-adrenergic blocker (non-selective for glaucoma therapy)
DOSE: Dogs, Cats: 1 drop in the eye '112 to 24h
- 194 -
University of Florida "" .. """'" .... "',.,"'"""', .. ,'""', .... , Veterinary Medical Center
FORlvIULATION: 0,5% ophthalmic solution 5 ml bottle; 0,5% gel

fonning solution 5 mL
NOTE: HUMAN PRODUCT
Tobramycin 0.3% Ophthalmic Solution
USE: Ophthalmic aminoglyeoside solution.
DOSE: Small Animal: I drop QID in affected eye(s)

Horse: 0.2 ml via lavage up to q Ih in severe bacterial
(melting) keratitis.
FORMULATION: 5 ml dropper tip bottle,
NOTE: H1JMAN PRODUCT
Tocopherol Vitamin E, VITAL E - 300
USE: For use in equine myopathies and acutc neurologic diseasc
DOSE: Administer injection 1M or SQ only, Equine. adult: 5 to 10

capsules once daily, capsule contents squeezed onto feed
FORMULATION: 1000 lU capsule (dl-alpha tocopheryl acetate); 300

IU d-alpha-tocopherol per ml, with 20% ethyl
alcohol and 1% benzyl alcohol
conversion for common forms of vitamin E:

1 USP or lU = 1 mg dl-alpha tocopheryl acetate '"
0,91 mg dl- alpha tocopherol = 0,735 mg d-alpha
tocopheryl acetate = 0,671 111g d-alpha tocopherol
Toothpaste C.E.T. Poultry Flavored
USE: Enzymatic toothpaste
- 195 -
DOSE: May be used daily or as directed
FORMULATION: C.E.T. poultry flavored contains Glucose Oxidase,

Lactoperoxidase, Sodium Monofluorophosphate in
a 70 g tube
Trace Elements MULTITRACE-4 Concentrate
USE: Trace elements to be added to TPN solution
DOSE: 0.2 to 0.5 ml per liter ofTPN solution
FORMULATION: Available in 1 m1 single dose vial each ml

provides:
zinc 5 mg
copper 1 mg
manganese 0.5 mg
chromium 10 mcg
NOTE: Must be diluted before use.
Tramadol HCL
USE: An analgesic which binds to certain opiod receptors and inhibits

reuptake of norepinephrine and serotonin - exact mechanism of
action is unknown. Useful in the treatment of acute or chronic
pain, may be used in combination with NSAIDS.
DOSE: Dog: 2.5 mglkg PO q4h; OR 5 mg/kg PO q6h. May lower dose
ifused in combination with NSAIDS(UF Pain
Management). Alternate dose: 4 mg/kg PO BID to QID.
Note, in humans the drug is started at 25 mg/dayand
gradually increased to a maximum of 400 mg/day.
Cat: 2 mg/kg PO q6 to 8h or q12h.
- 196 -
FORMULATION: 50 mg tablet; 10 mg/ml oral suspension

compounded in pharmacy - not very palatable, can
add Karo Syrup prior to administration.
Triamcinolone Acetonide 0.015% GENESIS TOPICAL SPRAY
USE: A glucocorticoid indicated for control of pruritus associated

with allergic dermatitis in dogs only. Recommend prior to use of
systemic steroids.
DOSE: Dogs: WEAR RUBBER GLOVES WHEN APPLYING

PRODUCT. Apply sufficient solution to wet area BID
for 7 days, then QD for 7 days, then QOD for an
additional 14 days.
FORMULATION: 0.015% aqueous solution containing propylene

glycol, denatured alcohol, and DMDM hydantoin.
Available in 16 oz bottle with trigger sprayer.
NOTE: Topical preparations can cause suppression of the hypothalamic-

pituitary-adrenal axis - wear rubber gloves when applying and
wash hands after use.
Triamcinolone Acetonide VETALOG
USE: A glucocorticoid with potent anti-inflammatory and prolonged

adrenocortical suppressive effects.
DOSE: Dog, cat: 0.05 to 0.1 mg/pound 1M, SQ, or PO daily. May
want to reduce dosage after 7 to 10 days.
lntralesional: 1 mg/cm diameter tumor (contraindicated in a
non-healed surgical wound).
Horse: 12 to 18 mg 1M or SQ; 2 to 6 mg per synovial cavity.

Total dose should not exceed 18 mg per horse
regardless of route of administration, may induce
laminitis.
- 197 -
FORt\1ULATION: 18 mg/3ml vial, suspension for injection
NOTE:
1. Can cause prolonged suppression of the hypothalamic- pituitary-
adrenal axis.
2. Can cause acute laminitis in horse.
Trifluridine 1 % Ophthalmic Solution VIROPTIC, and generic
USE: A fluorinated pyrimidine nucleoside with activity against

Herpes simplex virus, types I and 2, and vaccinia virus
DOSE: Use q2h during waking hours for the first 2 days then decrease
to 4 to 6 times a day; continue for 1 week beyond resolution of
clinical signs.
FORMULATION: 7.5 ml bottle with dropper tip, thimerosal as

preservative - SPECIAL ORDER
NOTE:
l. HUMAN PRODUCT.
2. Velyexpensive.
3. Store under refrigeration:
2 weeks@!). room temp (77°F) = 0% loss in potency
4 weeks@ room temp (77°F) = 7% loss in potency
8 weeks@ room temp (77°F) = 10% loss in potency
2.7 weeks @ body temp = 10% loss in potency
Also, pH decrcases over time and this may cause stinging (per
manufacturer)
Trilostane VETORYL
USE: An orally active synthetic stcroid analogue that selectively

inhibits 3 beta-hydroxysteroid dehydrogenase in the adrenal
cortex; approved for use in dogs for pituitary-dependent
hyperadrenocorticism and hyperadrenocorticism due to
adrenocortical tumor.
198 -
DOSE: Starting dose: Administer once daily. Follow guidelines

below:
Wei2ht ran2e in k2 Starting dose mg

> or = 4.5 to < 10 30
> or = 10 to < 20 60
> or = 20 to < 40 120 (2 x 60mg)
> or = 40 to < 60 180 (3 x 60mg)
After 10 to 14 days, perform physical examination and administer 4 to 6

hours post-dosing ACTH stimulation test; proceed as below:
Post-ACTH serum Post-ACTH serum I

I
cortisol mC2/dL cortisoinmol/L
<1.45 <40 Stop treatment; re··start
at decreased dose
1.45 to 5.4 40 to 150 Continue on same dose
>5.4 to 9.1 >150 to 250 Based on exam -
maintain dose or
incrcasc dosc
>9.1 >250 I Tncrease in itial dose
FORMULATION: 30mg and 60mg capsules
NOTE:
l. Do not use in dogs with primary hepatic disease or renal
insutIiciency
2. Do not use in pregnant dogs. Trilostane has been shown to be
teratogenic and may also lead to early pregnancy loss
3. for HUMANS: Wash hands after use; do not empty capsule
contents or attempt to divide capsules; woman who are pregnant
or may become pregnant should not handle capsules (see 2.
above)
4. Refer to insert for dosing patients whose clinical signs are not
controlled on once daily dosing.
- - - - - _ . _ - - - . _ - - - _...
Trimeprazine, prednisolone TEMARIL P
- 199 -
USE: Approved for use in dogs for relief of itching - regardless of

cause; caugh; and inflammation.
DOSE: Dog: Administer twice daily for 4 days then decrease dose by '12
of initial dose.
Dog up to 10 pounds - '12 tablet

Dog 11 to 20 pounds - 1 tablet
Dog 21 to 40 pounds - 2 tablets
Dog over 40 pounds - 3 tablets
FORMULATION: each tablet provides 5 mg trimprazine and 2 mg

presdnisolone
NOTE: Phenothiazine may precipitate seizures in epileptic patients; may

potentiate organophosphate toxicity.
Trimethoprim, Sulfa SMZ-TMP, generics
USE: Combination antibiotic
DOSE: Dog, Cat: Usual dose: 15 mg/kg of combination PO BID or

30 mg/kg PO QD (BID is recommended in some
dermatologic conditions).
Cat: 15 mg/kg IV BID, over 1 hour; human product diluted in
D5Wat 1 ml per 15 m! D5W
Horse: 15 to 25 mg/kg PO q l2h. It is suggested that for horses,
the tablets be administered at least one hour before
feeding hay.
Reptile: 30 mg/kg repeat dose in 24 hours, then q48h
Psittacine: 30 to 100 mg/kg/day PO, 1M, SQ, divide dose BID,
TID for gram negative enteric infections,
coccidiosis.
FORMULATION: Trimethoprirn/sulfamethoxazole:
Tablet: 480 mg, 960 mg
Oral suspension: 48 mg/m! of combination -
cherry flavored
- 200-
Injcction: IMP 80 mg/SMZ 400 mg per 5 ml vial;

or TMP 160 mg/SMZ 800 mg per 10 ml vial
NOTE:
I. Chronic use of sulfonamides and/or sensitivity may cause KCS.
2. May be linked to thrombocytopenia in Dobermans and
polyarthritis.
3. Occasionally causes diarrhea in horses.
4. Can cause pronounced sulfonamide crystalluria.
5. Liquid sulfa preps likely to be unacceptable to cats due to flavor
Tris-EDTA Otic Solution TrizEDTA
USE: A chelating agent used as a pre-soak in the ear 15 minutcs prior

to medicated therapies; to incrcasc thc cfficacy of the antibiotic
against pseudomonas infection
FORMULATION: 4 and 16 oz bottle; water based solution, pH 8
NOTE: Also refcrrcd to as tromethamine HCl and tctrasodium cdetatc
Tropicamide 1'Yo Ophthalmic Solution
USE: Topical product producing pupil dilation of shorter duration

than atropinc
DOSE: Onc drop 4 times daily
FORMULATION: 15 ml dropper bottle
NOTE: HUMAN PRODUCT
USE: A bacteriostatic macrolide antibiotic. It has becn used to manage

canine and feline colitis.
- 201 -
DOSE: Dog: Chronic colitis:40 to 80 mg/kg/day in 2 to 3 divided doses.

Mix with food or as a bolus mixed with watcr. Continuc
for 2 weeks, then taper.
FORMULA TION: Container of powder equivalent to 100 g of tylosin

base; 1 level teaspoonful (cooking measure) equals
2.7 grams of tylosin base (with actual weight of
approximately 4 grams). Can also be packed into
capsules.
Ursodiol
USE: May be useful as adjunctive therapy for the medical

management of cholesterol-containing gallstones and/or in
animals with chronic liver disease, especially where cholestasis
plays an important role - Veterinary Dmg Handbook, D. Plumb.
DOSE: Dog: 10 15 mgikg PO q24h; or 5 to 15 mg/kg PO q 12h with

immunosuppressive therapy.
Cat: 10- 15 mg/kg PO q24h
Give with food.
FORMULATION: 250 mg film coated, football shaped, cutable tablet
Valacyclovir VALTREX
USE: A human antiviral; a pro-drug that in humans is rapidly

converted to acyclovir; with activity only against actively
replicating viruses. Indicatcd fell' the treatment of EHV
neurological signs.
DOSE: 30 mg/kg PO q 12h
FORMULATION: lOOO mg tablet
Vasopressin
,,202 "
USE: Synthetic antidiuretic hormone (ADH). Increases the

permeability to water of the renal distal tubule and collecting
duct. Has a vasopressor effect. Aqueous fonn: diagnosis of
diseases of water metabolism.
DOSE: Dogs: Aqueous vasopressin 1 to 2 units SQ q4 to 6h.

Cats: Aqueous vasopressin 1 unit SQ q4 to 6 h.
Monitor water consumption, urine volume and specific gravity.
Alternative to epinephrine for CPR in small animals - 0.8 u/kg
FORMULATION: 20 units per I ml vial
Vinblastine VELBAN, generic
USE: Antineoplastic agent, lymphoma, mast cell tumor, some

carcinomas
DOSE: Dogs, Cats: 2 mg/m2 IV q7 days
FORMULATION: 10 mg vial
CONTRAINDICATIONS: Neutropenia <2,000/111 and bilirubinemia

>3.0 mg/dl.
TOXICITIES:
1. Leukopenia nadir 4 to 9days post injection with recovery noted
7 to 14 days.
2. Diarrhea and/or constipation has also been reported in animals;
diarrhea appears to be more frequent than constipation.
3. Perivascular slough.
Vincristine
USE: Antineoplastic agent, lymphoma, TVT, some carcinomas,

sarcomas, mast cell tumor
- 203-
DOSE: Dog and Cat: 0.5 to 0.75 mg/m2 IV q7 to 14 days. Use

butterfly catheter to administer drug. Inject drug over 5 to 10
seconds at final concentration of 1 mg vincristine/ml diluent.
Flush catheter with sterile saline.
For TVT: 0.5 mg/m2 IV every 7 days for 4 to 6 weeks
To increase platelet count: 0.025 mg/kg IV
CONTRAINDICATIONS: Neutropenia <2,000/111 and bilirubinemia

>3.0 mg/ml.
TOXICITIES:
I. Vincristine has been observed to induce a peripheral neuropathy
2. Diarrhea and/or constipation has also been reported in
animals; diarrhea appears to be more frequent than constipation.
2. Mild neutropenia.
3. May increase platelet count.
FORMULATION: 1 mgll ml vial
NOTE: HUMAN PRODUCT. Store in refrigerator.
Vinorelbine
USE: Antineoplastic agent used for treatment ofMCT and also

demonstrates increased efficacy against bronchoalveolar
carcinoma
DOSE: 15 to 20 mg/m2 IV every 1 to 2 weeks.
FORMULATION: 10mg/ml, I ml vial
NOTE: Solution must be further diluted prior to administration. Vials

are stable at room temperature for up to 72 hours; diluted
solutions are stable for 24 hours @ 41 to 86 degrees F.
Vitamins for Infusion INFUVITE
- 204-
USE: Multivitamins for dilution in infusions only.
FORMULATION: 2 vials per set once opened discard remainder.
NOTE: Vitamins should be added to parenteral nutrition immediately

prior to administration; to be administered within 24 hours.
Dilute into minimum of 500 ml IV fluids. Store in refrigerator.
Vitamin A and Vitamin D Ointment
USE: Ointment for protection of minor burns, skin irritations,

chapping.
DOSE: PRN
FORMULATION: 2 oz tube
NOTE: HUMAN PRODUCT. May be covered with bandage or

dressing.
Vitamin A, D3 Injection
USE: For prevention and correction of vitamin A and D deficiency

states.
DOSE: Dog: 0.5 to 2 ml 1M

Cat: 0.25 to 0.5 ml 1M
Psittacines, Raptors: 5,000 to 10,000 IV/kg vitamin A, 1M
every 3 days for 3 treatments, then once every 2 weeks for 2 to 3
weeks
FORMULATION: 100 ml multiple dose vials, supplying per ml:

Vitamin A 500,000 IU, Vitamin D3 75,000 IV,
and Vitamin E added as an antioxidant in a base
with polyoxyethylated castor oil and benzyl
alcohol 2%
NOTE: Store opened vials in refrigerator.
- 205-
University of Florida ............................. " ......... Veterinary Medical Center
Vitamin A, D, E, B Complex, Folic Add NUTRI-CAL
USE: High calorie palatable dietary supplement in a low volume form

for dogs and cats.
DOSE: As a supplement: Give 1Y2 teaspoonful pcr 10 Ib daily. As a

food source when animal is off'feed: Give I tablespoonful per
10 Ib daily.
FORMULA TION: 41/. oz tube contains vitamins, minerals; supplies

per teaspoonful fat 34.5%, protein 1.5%, and 26.5
kcal/6 g (teaspoonful)
WARNING: Excessive supplementation can result in protein deficiency

and vitamin A toxicosis
Vitamin B Complex
USE: An injectable nutritional supplement
DOSE: Cattle, sheep, horses: 1 ml to 5 ml per 100 pounds 1M or IV
FORMULATION: Aqueous solution provides per m!: Thiamine Hel

150 mg, riboflavin 2 mg, niacinamide 150 mg, d-
panthcnol 10 mg, pyridoxinc HCI 10 mg, inositol
20 mg, choline chloride 20 mg with benzyl alcohol
2'10.
NOTE:
1. Anaphylactogenesis to parenteral thiamine Hel has been
rep01ied; administer slowly and with caution in doses over
50mg.
2. Intravenous route best administered over several hours mixed
with the maintenance Huid thcrapy.
Vitamin D
- 206-
University of Florida ..................................... ". Veterinary Medical Center
USE: Vitamin D is a fat-soluble vitamin (also considered to be a

hormone) available from natural sources (fish liver oils) or from
conversion of7-dehydrocholesterol and ergosterol.
DOSE: One USP unit or one IU Vitamin D activity is equal to 0.025mg

vitamin D (lmg = 40,000 units). "Vitamin D" refers to both
ergocalciferol (D2) and cholecalciferol (D3).
Ergoca1ciferal = pure vitamin D2; available for oral or 1M

adnlinistration
dihydrotachysterol (DHT) - 1 mg approximately equal to 3 mg

vitamin D2 (120,000 IV); available for oral administration
cholecalciferol CD3) - 1mg provides 40,000 IU vitamin D

activity; available for oral administration
FORMULA nON: 400 IlJ Vitamin D as cholecalciferol - SPECIAL

ORDER
Vitamin E 50 mg/ml, Selenium E-SE, MU-SE
USE: Selenium, Vitamin E (tocopherol) combinatiolls:

E-SE 2.5 mg selenium, 50 mg (68 IlJ) d-alpha tocopherol per
m1. For prevention and treatment of selenium-tocopherol
deficiency (myositis) in horscs; for TV, 1M usc.
MU-SE 5 mg selenium, 50 mg (68 IlJ) d-alpha tocopherol per

m1. For prevention and treatment of selenium-tocopherol
deficiency in weanling calves and breeding beef cows; for SQ,
1M use.
WITHDRA WAL TIMES: MU-SE: 30 day withdrawal time for beef

cattle.
NOTE: NOT FOR LACTATING DAIRY CATTLE
- 207 -
DOSE: Raptors: 0.06 mg/kg 1M of selenium once a week; 10 to 50

IU/kg/day 1M of vitamin E
Vitamin/Mineral Hvpoallergenic Supplement TOT ALFORMULA
USE: Vitamin and mineral supplement, contains no yeast, wheat,

com, soya, sugar, phenol, added salicylates, animal/dairy
products, artificial color or flavoring agents.
DOSE: Dog: One tablet PO per 30 pounds of body weight, per day.
FORMULATION: 90 tablets per bottle; each tablet contains vitamins

as well as minerals, choline, hesperidin complex,
bioflavinoids, rutin, inositol, PABA, calcium
pantothenate.
NOTE: HUMAN PRODUCT
Vitamin, Mineral Supplement PET-TABS, PET-TINIC
USE: Oral vitamin/mineral supplement.
DOSE: Dogs, Cats: 0.5 to 2 tablets daily or 2.5 ml per 25 lb BID

Foals and Horses: 0.5 to 2 ounces per day.
FORMULATION: Pet-tinic in 4 OZ; Lixotinic in gallon - special order
LIXOTINIX
Contents er 5 ml
- 208-
I Vitamin A 1,000 lU
Vitamin D ]00 lU
Niacin 10 mg 10 mg 10 mg
Thiamine (B 1) 810 mcg 2.0 mg 2.0mg
Riboflavin (B2) 1 mg I mg 1 mg
Pyridoxine (B6) 100 mcg 1 mg 1 mg
Cyanocobalamin(B12) 0.5 mcg 2.1 mcg 2.1 mcg
Vitamin E 2IU
Iron, elemental 2.25 mg 12.5 mg 12.5 mg
Zinc 1.4 mg
Potassium 0.4%
Copper 100 mcg 0.2mg 0.21 mg
Magnesium 0.15%
Manganese 25 mcg
Iodine 52mcg
Calcium 2.5-3.5% 0.0 - 0.5'%
Phosphorus 2.5'% 0%
Salt 0.1-0.6% 0.0 - 0.5'%
chloride 0.1%
Voriconazolc, VF'END
USE: A triazole antifungal agent fOI11mlated into an ophthalmic

preparation used for the treatment of equine fungal keratitis.
DOSE: O.2mL in the eye or via palpebral lavage catheter Ltp to every 4
hours.
FORMULATION: 1% ophthalmic solution, 20ml in MDV
Xylazine, ANASED
USE: An alpha-2 agonist, non-narcotic, centrally acting sedative.

analgesic with muscle relaxant effects. Its use in food animals is
extra-label.
- 209 -
DOSE: Dogs, Cats: 0.2 to 1.1 mg/kg IV or 0.44 to 2.2 mg/kg 1M or SQ

(premedication with atropine recommended)
Horse: 0.5 to l.0 mg/kg IV, 1 to 2 mg/kg 1M;
Bovine: 0.02 to 0.1 mg/kg standing dose IV, 1M
Swine: 0.5 mg/kg IV
FORMULATION: 20 mg/ml, 100 mg/ml
TOXICITY: May be reversed with YOHIMBINE. Dogs require

O.lImg/kg TV and cats require 0.5 mg/kg IV. May be
reversed with TOLAZOLINE.
NOTE:
l. Use 20 mg/ml preparation in cows.
2. Will cause bloat and abolishes swallowing reflex in bovines
(regurgitation and aspiration).
3. CONTRAINDICATED in Brahmans due to sudden death.
4. Emesis commonly occurs in cats and occasionally in dogs.
5. Dogs might develop severe aerophagia.
6. Can cause A V block.
Yohimbine YOBINE
USE: Competitive alpha-2 adrenergic receptor antagonist, crosses the

blood-brain barrier, used as xylazine reversing agent and
antidote approved for use in dogs only
DOSE: Dog: 0.11 mg/kg IV slowly. Effects should be seen in 1 to 3

minutes.
Horse: To prevent or treat intestinal ileus: 75 mcg/kg slow
infusion over 20 minutes.
NOTE: Use with caution in epileptic dogs or dogs prone to seizures
Zinc Oxide, Cod Liver Oil, Petrolatum Ointment DIAPER RASH

OINTMENT
- 210-
University of Florida ............ " ........ " .... "" ...... " Veterinary Medical Center
USE: Mild astringent, protective and antiseptic action.
DOSE: Small and Large Animals: Apply topically q8 to 12h.
FORMULATION: 4 oz tube
NOTE: DO NOT USE rN CATS, or any animal likely to lick it off.
- 211 -
University of Florida ........................................ Veterinary Medical Ccntcr
APPEl\DIX
Conversion Table Body Weight to Meters Square ............................... 213

Conversion Table for Metric Measurements ........................................ 215
Table of Small and Large Volume Fluids ............... ,............... ,.. ,., ....... 216
Table of Pharmacy Biologicals ............................................................ 217
Cortrosyn Protocol .... , ... ,., ......... , , , " ........... , ... "'" . , ., ... , ... , .... 222
Expiration Dating, ............................. , ... , .......... , ................ ,223
Vaccine Guidelines: VMC Outpatient Medicine ................................. 218
Omnicell Notes ....................................... ,....................... ,.................... 224
Heartwonn Prevention Product List.. ................................................... 228
Shampoos, Rinses and Sprays .............................................................. 230
Ophthalmic Product List ...................................................................... 230
Otic Product List ............................. ,.............. " .................................... 232
Flea Control Product List ..................................................................... 232
Fentanyl Patches, ............ ,.......... ,..... ,., .... ,........................ ,........... ,........ 234
Soaker Catheter Notes .................................... ,............................ " ....... 235
Diets and Iron Suppiementation ........................................................... 238
Energy Requirements ...................................................... ,.................... 239
TPN Calculation Sheets for Dog, Cat .................................................. 241
TPN Completed Prescription Examples ................... , .............. ,243
- 212 -
Conversion Table Weight to Meters Square - Dogs
kg m2 kg m"
0.5 0.06 26 0.88
1 0.10 27 0.90
2 0.15 28 0.92
3 0.20 29 0.94
4 0.25 30 0.96
5 0.29 31 0.99
6 0.33 32 1.01
7 0.36 33 1.03
8 0.40 34 l.05
9 0.43 35 1.07
10 0.46 36 1.09
11 0.49 37 1.11
12 0.52 38 1.13
13 0.55 39 1.15
14 0.58 40 1.17
15 0.60 41 1.19
16 0.63 42 1.21
17 0.66 43 1.23
18 0.69 44 1.25
19 0.71 45 1.26
20 0.74 46 1.28
21 0.76 47 l.30
22 0.78 48 l.32
23 0.81 49 l.34
24 0.83 50 1.36
25 0.85 51 l.38
- 213 -
Conversion Table Weight to Meters Square - Cats
kg m" kg m2
2.3 0.165 4.9 0.270
2.4 0.170 5.0 0.273
2.5 0.175 5.1 0.278
2.6 0.180 5.2 0.282
2.7 0.185 5.3 0.286
2.8 0.187 5.4 0.290
2.9 0.192 5.5 0.294
3.0 0.197 5.6 0.297
3.1 0.202 5.7 0.300
3.2 0.207 5.8 0.303
3.3 0.211 5.9
3.4 0.215 6.0 0.311
3.5 0.219 6.1 0.315
3.6 0.222 6.2 0.319
3.7 0.227 6.3 0.323
3.8 0.232 6.4 0.326
3.9 0.237 6.5 0.329
4.0 0.238 6.6 0.332
4.1 0.244 6.7 0.335
4.2 0.247 6.8 0.338
4.3 0.250 6.9 0.342
4.4 0.253 7.0 0.345
4.5 0.256 7.5 0.360
4.6 0.261 8.0 0.379
4.7 0.264 8.5 0.394
4.8 0.267 9.0 0.408
- 214-
University of Florida ............................ " ....... ". Veterinary Medical Center
Weight, Length, Volume Conversion Equivalents
kilogram kg 1000.0 g
decigram dg 0.1 g
milligram mg 0.001 g
microgram flg O.OOO,OOlg
--
Weight
1 mg 1160 gr (grain)
15mg 1/4 gr (grain)
30mg 12 gr (grain)
60mg I g1' (grain)
1000 mg 1 g (gram)
1000 g 1 kg 2.21b
loz 28.35 g
80z 0.51b 226.8 g
1602 1 Ib 453.6 g
Length
1 mm
lcm
0.04 in
0.4in
cm- - - -_ _ I
I;
I in 2.54
Ll
Volume
1 tsp (tcaspoonful) 5 ml
I tb,p (tabl"poooful)
I f1 oz (fluid ounce) 30 ml
I cup 237ml 8 ounces
1 pt (pint) 473 ml 16 ounces
1 qt (quart) 946 ml 32 ounces
1 gal (gallon) 3785 ml 128 ounces
- 215 -
Small and Large Volume Fluids
Generic name Volume

Empty TPN bag 1L
Empty TPN bag 4L
Amino Acids 8.5% w Electrolytes 500ml
Calcium Borogluconate 23% 500ml
Dextrose 2.5% and Saline 0.45% 1000 mI
Dextrose 5% 1L
Dextrose 50% (in glass or plastic) 50ml, 500 ml
Fat Emulsion 20% (INTRALIPID) 250 ml
Hetastarch 6% in 0.9% Saline 500ml
Lactated Ringers 500 mI, I L
Plasmalyte 56 +D5W 1L
Plasmalyte 148 +D5W or Normosol R +D5W 1L
Plasmalyte 148 or Normosol R 1L
**Normosol R 3L
Plasmalyte A or Normosol 5L
Saline 0.9% 10 mI, 100 ml, 250 ml,
500 ml, 1 L, 5 L
Saline 0.9% for lITigation 1 L pour bottle
Saline 7.2% HYPERTONIC IL
Sodium Bicarbonate 8.4% 50 ml
Sterile Water 10 mI, 50 mI, 1 L, 5 L
Sterile Water for Irrigation 1 L pour bottle
** We will use 3L untiI5L Nonnosol becomes cost effective.
- 216 -
Biologicals
CN DA2P - CPV Vaccine - VANGUARD PLUS 5
CN A2P, Bordetella bronchiseptica (mod. live) - Intra-Trac 3ADT
(in tranasal)
CN Borrelia burgdorferi - bacterial extract - RECOMBITEK LYME
CN Leptospirosis 4 serovars - VANGUARD L4
CN Influenza Vaccine, H3N8
EQ Encephalomyelitis EE/WE/VE Killed w Tetanus Toxoid
EQ Encephalomyelitis EEIWE Killed w Tetanus Toxoid
EQ Influenza (modified live) - FLU AVERT LN. - intranasal
Pythium Insidiosum AllerginicExtract 3 ml (*SPECIAL ORDER
ONLY*)
EQ Rhinopneumonitis Vaccine killed - PNEUMABORT-K + 1b
EQ Rhinopnemonitis (Modified Live) - RHINOMUNE
FE Immunodeficiency Virus Vaccine - Killed - FEL-O-VAX FIV
FE Leukemia Vaccine - FEL-O-VAX LvK
FE Rabies (live canarypox vector) - PUREVAX Feline Rabies
FE Rhino, Calici, Panleuk Vaccine (modified live) - ECLIPSE 3
FE Rhino, Calici, Panleuk Vaccine (killed) - FEL-O-VAX PCT
FERRET Distemper (live canarypox vector) - PUREVAX Ferret
Rabies Vaccine (killed) - IMRAB 3 TF
Rabies Vaccine (killed) Livestock - IMRAB 3
SW ER Bac/L5 Gold (**SPECIAL ORDER ONLY**)
Tetanus Antitoxin 1500 unit or 10,000 unit vial
Tetanus Toxoid Single Dose (Aluminum Precipitated) - should be
refrigerated, but stable ifleft at room temperature 24 to 48 hours
West Nile Vaccine (killed) - Fort Dodge
West Nile Vaccine - Live flavivirus chimera - PreveNile
- 217 -
2010 Canine and Feline Vaccination Guidelines*

University of Florida, College of Veterinary Medicine
FELINE VACCJ~ATIONS
Core Vaccines
1. FVRCP
• Begin vaccination at 6 - 8 weeks of age
• Booster every 2 - 4 weeks until 14 - 16 weeks of age
• Revaccinate in I year then every 3 years (or sooner if 'at risk')
• Administer subcutaneously (under theskin) over the right
forelimb as distally as possible
(Modified live, parenteral vaccine)
2. RABIES
• Vaccinate at 12 - 16 weeks of age
• Revaccinate in 1 year, then every 3 years (if killed parenteral
product)
• Alachua County requires 3-year rabies as of January 2001
• Administer subcutaneously in right rear leg as distally as possible
• Can use nan-adjuvanted I-year duration of immunity vaccine
(canary pox vectored, parenteral)
Non-Core Vaccines
I. FELINE LEUKEMIA
• Recommended for 'at risk', FeLV negative cats only
• Vaccinate at 8 - 10 weeks & booster in 3 - 4 weeks
• Revaccinate annually if 'at risk'
• Administer subcutaneously in lcft rear leg as distally as possible
• Consider as CORE for all kittens and then 'at risk' after 1 year
• Killed, parenteral and canary-pox-vectored, intradermal available
2. CHLAMYDOPHILA
• Not used - consider for 'at risk' cattery
3. FELINE INFECTIOUS PERITONITIS

• Not used - consider for 'at risk' cattery
- 218 -
4. BORDETELLA
• ).[ ot used - consider for 'at risk' cattery
5. FELINE IMMUNODlFFICiENCY ViRUS

• Not used - consider for "at risk" cats
• Reconsider Lise when there is not interference with testing
CANINE VACCINA nONS
Core Vaccines
1. DA 2PP
• Bcgin vaccination at 6 - 8 weeks of agc
• First vaccination using recombinant distemper antigen (6-8 weeks
of age)
• Booster every 2 - 4 weeks until 14 -16 weeks of age (using high
titer parvo vaccine)
• Revaccinate in 1 year then every 3 years (or sooncr if 'at risk')
• Administer subcutaneously over thc right forelimb as distally as
possible
(Modified live, parenteral vaccinc)
2. RABIES
• Vaccinate at 12 -16 weeks of age
• Revaccinate in 1 year thcn every 3 ycars (killed, parenteral)
• Alachua County requires 3-year license as ofJanuary 2001
• Administcr subcutaneously in right rear leg as distally as possible
Non-Core Vaccines
1. Bordctella/Parainfluenza
• Begin vaccination at > than 3 weeks of agc if using intranasal
product (or 7 -10 days prc-boarding) (Modified live, intranasal)
• If using the killed, parenteral product, givc subcutaneously in the
left rear leg as distally as possible (starting at 6-8 weeks of age)
and booster 3 weeks later
• Boostcr every 6- 12 months as needed depending on risk
2. Leptospirosis
- 219-
• 4-way leptospirosis vaccine

• Start at 12 weeks of age and booster at 16 weeks of age, then every 6
to 12 months depending on risk
• Miniatme dachshunds and some toy breeds may be more at
risk for anaphylaxis
• Administer subcutaneously in left front leg as distally as possible
• Fractionated, microfiltered bacterin, parenteral
3. Lyme
• Vaccinate at 12 weeks of age, booster in 3-4 weeks
• Revaccinate yearly
• Record site used for vaccination
• Only used if at risk or traveling to at risk areas
• Recombinant, parenteral
4. Periodontal Disease Vaccine

• Not used routinely - have in stock and consider if "at risk" as an
adjunctive control
5. Canine Inf1uenza
• Available for usc in at risk patients or when required by boarding
kennel
• Vaccinate at 12 weeks of age, booster in 3 --- 4 weeks.
• Revaccinate yearly
• Adults must be boostered 2 - 3 weeks after initial vaccination
• Only used if at risk (show dogs, boarding in at risk areas) or
traveling to at risk areas
• May only be prescribed by VMC Outpatient Medicine/Dentistry
Veterinarians
• Killed, parenteral
6. Corona
• Not used - consider for "at risk" dogs
7. Giardia
• Not used - consider if"at risk" as an adjunctive control
*These are only recommendations and should be used in light of each
- 220 -
University ofFlorida ......... « ............................. Veterinary Medical Center
indi vidual Vctcrinarian' s doctor/patient/client relationship and indi vidual

risk assessment of each patient. Vaccination is critical in the prevention
and elimination of disease. In general, veterinary vaccines are safe and
efficacious and the benefits outweigh the risks. Recognize that vaccina-
tion is a medical procedure that should include the same considerations
and reasoning skills required for any other medical treatment or surgical
proccdurc.
REFERENCES:
Greene's Infectious Diseases of the Dog and Cat, Chapter 100

Immunoprophylaxis, Appendix 1 and 2
Current AAFP and AAHA Vaccination Guidelines
- 221 -
VMC Cosyntropin Policy
Rationale: Aliquots should be admixed under sterile conditions and

stored under controlled conditions to protect our clients from inaccurate
charges and to protect our patients from receiving improperly admixed /
stored product.
Admixture instructions: Aseptically reconstitute 1 x 0.2Smg vial with

1ml 0.9% sodium chloride for injection. Final concentration of solution is
0.2Smg/ml.
Stability: 1. Stable 6 months at -20 degrees C

2. Stable 24 hours at room temperature
3. Stable 21 days under refrigeration (2-8 degrees C)
Procedure:
1. DVM to write prescription for cosyntropin 0.2Smg vial.
• DVM to specify the following on original prescription:
o Dose in mcg/kg
o Request for pharmacy to mix if more than one
dose to be used out of vial
o Remainder to be drawn up and stored for future
use
2. For repeat doses, syringes will be properly labeled for specific
patient use and stored in freezer for up to 6 months in pharmacy.
StudentlDVM to request extra doses at future dates as needed.
Put request on in-patient prescription form (there will be no
charge).
3. Pharmacy will automatically waste expired doses.
Charging: Patient/client will be charged for 1 vial Cosyntropin with

dispensing fee on initial prescription. An extra compounding fee will be
applied only if more than 7 doses are requested out of a vial.
- 222-
Expiration dating
Prescription labels must contain an expiration date for the dispensed

product. Generally, a date of one year is defaulted to unless:
a) the manufacturer's date is less than one year

b) the product has been reconstituted
c) the product has special instructions to be followed after entering
the vial for the first time, or is a single dose vial/ampule
d) the product has been repackaged, drawn into syringes or
otherwise manipulated
The following information serve as a guideline for assigning expiration

dates.
Injectables (preserved 48 to 72 hours

solutions) drawn into
syringes
Ivermectin injection for oral 30 days
use (in syringes)
Ophthalmic solutions 3 to 6 months
packaged into sterile vials
Compounded products Variable - refer to specific
formulation instructions
Mixed lots/expiration dates Use shortest datingor one
year whichever is sooner
Unreconstituted product No date - provide
instructions to assign date
unpon reconstitution
Repackaged injectable 30 to 90 days
solutions with preservatives
Repackaged preservative- 24 hours
free injectable solutions
- 223 -
Omnicell
Omnicell training will be done by the System Administrator or the

Pharmacy Omnicell Technician. No user will be given Omnicell
privileges without training.
The Omnicell should be used to obtain medications only if the patient is

currently being treated at the VMC. Any medications needed for a non-
hospitalized patient should be prescribed and dispensed from the
pharmacy. The Omnis are designed to be used for emergency
medications, supply items and first doses - until medications can be
pulled from the pharmacy, after hours controlled substances, or
outpatient treatments, and secured storage of patient specific controlled
substances. The Omnis have sufficient inventory for a four day weekend
(if used as described above
Students and technicians may only remove medications from the

Omnicell pursuant to an order from the veterinarian providing care to the
patient. The ordcr may be written and signed off on by the veterinarian,
or the order may be verbal. Verbal orders should be documented in the
patient record as soon as possible. Any other use of medications
constitutes practicing veterinary medicine without a license.
Medications should not be transferred between patients without notifying

the Pharmacy so that appropriate corrections to the medical history and
the patient's bill can be made
Omnis have a bin/drawer available for secured storage of prescribed

controlled substances - known as the LOCKBOX.
All activity at the Omnicell unit is recorded by date, time, location, user,
patient and medication. Automatic reports are generated for every
"event" at the unit, and reviewed daily. Irregularities, null transactions,
and discrepancies will be addressed by the pharmacy manager/system
administrator
- 224-
Omni Words for the Wise
1. RETURNS - RETURN an item to the Omni from which it came,

preferably within 24 hours of the original issue from the Omni. RETURN
to the EXACT same patient it was issued for. There must be a
corresponding previous issue or the return will not be credited off the
client's account. If you are unsure - return directly to the Pharmacy.
Usable returns - items may be returned to the Omnicell and the

client's account will be adjusted. This applies only to items that
came from the Omnicell. Usable returns DO NOT include opened
single dose vials, opened and reconstituted multiple dose vials,
injectables that have been pulled up into syringes, fluids out of the
overwrap.
Unusable items include opened single dose vials, opened and

reconstituted multiple dose vials, injectables that have been pulled
up into syringes, fluids out of the overwrap. Unusable items should
be returned to the pharmacy. Unusable controlled substances should
be returned to the pharmacy, labeled and placed in the Omnicell
Return Bin or Lockbox Bin
2. GREEN BUTTON AND FLASHING LIGHT - to remove any item

inside the glass doors - you must "TOUCH THE GREEN BUTTON"
under the item.
3. PLEASE READ THE PROMPTS ON THE SCREEN, they will

guide you through the transaction and tell you if the drug is issued by the
MG, by the ML, or by the VIAL.
4. FINDING THE PATIENT IN THE OMNI- Patient fields are

populated from Cornerstone to the Omnicell Server and then out to each
Omncell Unit. For patients that are admitted to the hospital and entered
into Cornerstone, the medical record # will populate the Room # on the
Omnicell. This allows user to search by patient name (last name, patient
name) or by medical record # (Room # field on Omnicell).
5. After Hours - the patient fields will not be populated by Cornerstone

after hours. Each patient admitted to the VMC after hours will need to be
manually entered at each Omnicell unit (the units communicate to the
- 225-
Omniserveer but not to one another). These patients are known as TEMP
PATIENTS. On the following business day, the pharmacy will reconcile
TEMP PATIENTS with Cornerstone and the Omnicell charges will flow
across the interface to Cornerstone.
6. TEMP PATIENTS - Refrain from the use of "Emergency,

Emergency" as a temp patient name. Please provide as much info as
possible, especially if you do not know the medical record (emergency
pack number). "Emergency, colic" and "HBC" are also poor choices.
One weekend can have multiple "Emergency, colic" admissions, making
con-ect reconciliation nearly impossible on Monday morning. If the
patients are not reconciled correctly with Cornerstone, patients may not
be charged for items they did use or charged for items they did not use.
Provide the most information you can to help identify the patient. Include
the record # if known.
7. RECEIPT - If you do not get a "receipt" from the Omni, you probably
missed a prompt and did not answer a question. Unless the printer is out,
no receipt means your transaction will not charge properly, a NULL
transaction will result and we will be calling you!!
8. RECEIPT tear off the receipt DOWNWARD against the cutting edge
to avoid a JAM!
9. (GENTLE) TOUCH SCREENS - The touch screens work very well

if you use only your fingertip to touch the center of the spot! Using the
tip of a pen or syringe, or striking the touch pad roughly will damage the
sensitivity of the touch screen. If you have a screen that is not responsive
- please call xt 4820
10. LA-ICu/FOAL UNIT Fluids and Plasma - when issuing fluids

that are not stored in the Omnicell itself (as in Foal Unit and 5000ml
fluid bags) return the key by choosing RETURN FLUID KEY from the
menu. I fyou choose the fluid and the RETURN ITEMS button ---you
will create an inaccurate client charge and and inaccurate inventory level.
11. MATRIX DRAWERS - low security you can pull a lot out of a
matrix drawer. Please remember to select each item that you remove -
otherwise the inventory will be inaccurate, which means it may not get
restocked, and the patient is not charged for items/medications that were
- 226-
used.
Pharmacy will be happy to assist you (ext 4-4614) or retrain as needed.

Please contact us to get the correct answer to your question.
We will contact you if we see any problems with your name as the user.
Ifwe continue to see problems (null transactions, discrepancies, etc) after
retraining, Omnicell privileges may be revoked.
DO NOT allow others to use your log-in - You will both loose Omnicell
privileges.
- 227-
HEARTWORM PREVENTATIVE PRODUCTS
Heartgard tablets for dogs (no flavoring added)

All strengths indefinitely backordered as of April 2010
68mcg up to 25 pounds None available

136 mcg 25 to 50 pounds While supplies last
272 mcg 51 to 100 pounds None available
In terceptor
2.3 mg Up to 10 pounds Brown
5.75 mg 11 to 25 pounds Green
11.5 mg 26 to 50 pounds Yellow
23 mg 51 to 100 pounds White
Revolution for DOGS

15 mg tube Up to 5 pounds Mauve pack
30mg tube 5.1 to 10 pounds Purple pack
60mg tube 10.1 to 20 pounds Brown pack
120mg tube 20.1 to 40 pounds Red pack
240mg tube 40.1 to 85 pounds Teal pack
240mg + 120mg tube 85.1 to 130 pounds Combination pack
Revolution for CATS

15mg tube Up to 5 pounds Mauve
45mg tube 5.1 to 15 pounds Blue pack
Combination of tubes Over 15 pounds Combination
- 228 -
Sentinel (dogs only) = Intercejltor + Program

2.3 mg/46 mg 2 to 10 pounds Brown
5.75 mgl115 mg 11 to 25 pounds Green
11.5 mg/230 mg 26 to 50 pOlmds Yellow
23 mg/460 mg 51 to 100 pounds White
- 229-
University of Florida ........................................ V eterinaryMedieal Center
SHAMPOOS, RINSES and SPRAYS

BENZOYL PLUS Shampoo 8 02
DERMAL SOOTHE Shampoo 8 02
DOUXO Shampoo 500 ml
ESSENTIAL FATTY ACID Shampoo 1602
ETIDERM Shampoo 8 oz
HYDRA-PEARLS Shampoo 1202
KETOCHLOR Shampoo 8 02
HYLYTefa Cream Rinse 80z
Dermal Soothe Cream Rinse 12 oz

ResiCHLOR Leave-On Lotion 8 oz
ResiCORT Leave-On Lotion 8 02
ResiKETOCHLOR Leave-On Lotion 8 02
ResiSOOTHE Leave-On Lotion 8 oz
MicroPearls DERMAL-SOOTHE Spray 12 oz
OPHTHALMIC PRODUCTS (topical)

Antibiotic!Antiviral!Antifungal
Chloramphenicol 0.5% Ophthalmic Ointment
Ciprot1oxacin 0.3% Ophthalmic Solution 5 ml
Gentamicin sulfate 0.3% Ophthalmic Solution 5 ml
Natamycin 5% Ophthalmic Suspension 15 1111
Neomycin-PolymyxinB-Gramicidin Ophth Solution 10 ml
Oxytetracycline-PolymyxillB Ophthalmic Ointment (Backordered
indefinitely as of April201O)
Tobramycill Ophthalmic Solution 5 1111
Trioptic P Ophthalmic Ointment (Neo-PolyB-Bae)
Voricona201e 1% Opthalmic Solution 20ml (Compounded)
Anti-Inflammatory
Prednisolone Acetate 1% Ophthalmic Suspension 10 ml
Diclofenac 0.1 % Ophthalmic Solution 2.5 ml or 5 ml
Flurbiprofen 0.03% Ophthalmic Solution 2.5 ml
- 230 -
Antibiotic - Anti-Inflammatory Combinations

Neomycin-Polymyxin-Dex 0.1 % Ophthalmic Ointment
Neomycin-Polymyxin-Dex 0.1 % Ophthalmic Suspension 5 ml
Trioptic S Ophthalmic Ointment (Neo-PolyB-Bae HC 1%)
(Backardered indefinitely as afApril 20J 0)
Glaucoma
Pilocarpine 2% Ophthalmic Solution 15 ml
Timololmaleate 0.5'1'0 Ophthalmic Solution 5 ml
Dorzolmnide 2% Ophthalmic Solution 10 ml
Xalatan Ophthalmic Solution 2.5 ml
Artificial Tears/Lubricants
ArtificialT ears 15 ml
HypoTears Ophthalmic Solution 30 ml
GenTeal 0.3% Ophthalmic Gel 10 ml
GenTeal Ophthalmic Solution 25 ml
Lubricant Eye Ointment 3.5g
Mydriatic Agents
Atropine 1% Ophthalmic Solution 15 ml
Atropine 1% Ophthalmic Ointment
Phenylephrine 2.5% 15 ml, 10% 5 ml
Tropieamide 1% Ophthalmic Solution 15 m1.
Misc
Cyclosporine 0.2% Ophthalmic Oimment 3.5 g
Proparacaine 0.5% Ophthalmic Solution 15 ml- SPECIAL ORDER
Ophthalmic Juigating Solution 4 oz
Sodium Chloride 5'% Ophthalmic Solution 15 ml
Sodium Chloride 5% Ophthalmic Ointment
- 231 -
OTIC PRODUCTS
Conofite 1% Lotion 30 ml
Ear Syringe
EpiOtic Advanced 4 OZ, S oz
Gentamicin, Betamethasone Otic 7.5 ml
Malacetic Solution 4 OZ, 16 oz
Neomycin-Polymyxin B-HC 1% Solution lO ml
Panalog Ointment 15 g, 30 g
Surolan Otic Suspension 30ml
Sweet Pea & Vanilla Otic Cleanser SOZ
Synotic 8 1111
Tresaderm 7.5 ml, 15 ml
TrizEDTA Otic Solution 4 OZ, 16 oz
FLEA CONTROL PRODUCTS
Topical
Frontline Spray 250 ml, 500 ml
Knockout Spray F or Dogs 16 oz
Advantage (4 per pack):

Cats less than 9 pounds 0.4 ml tubes
Cats greater than 9 pounds 0.8 ml tubes
Dogs less than 10 pounds 0.4 ml tubes
Advantix (4 per pad.):

Dogs less than 10 pounds 0.4 ml tubes
Advantage Multi (6 per pack):

Cats 5.1 to 9 pounds 0.4 ml tubes
Cats 9.1 to IS pounds O.S ml tubes
- 232 ..
University of Florida ........................................ Veterinary Medica! Center

Dogs 9.1 to 20 pounds 1 m! tubes
Dogs 20.1 to 55 pounds 2.5 ml tubes
Dogs over 55.1 to 88 pounds 4 m! tubes
Frontline Plus with methoprene (3 per pack)

All Cats 0.5 ml pipettes
Dogs 0 to 22 pounds 0.67 ml pipettes
Dogs 23 to 44 pounds 1.34 ml pipettes
Dogs 45 to 88 pounds 2.68 m) pipettes
Dogs 89 to 132 pounds 4.02 m) pipettes
Revolution - see Heartworm Preventative Products
Comfortis for DOGS

140mg 5 to 10 pOlmds
270mg lO.1 to 20 pounds
Program for DOGS

90 mg 11 to 20 pounds
204.9 mg 21 to 45 pounds
Program for CATS

90 mg Up to 6 pounds
Sentinel for dogs - see Heartworm Preventative Products

See also nitenpyram (CAPSTAR) and spinosad (COMFORTIS)
- 233 -
University of Florida .............. "" ..... " ............... Veterinary Medical Center
CLIENT HANDOUT: Fentanyl Transdennal Systems
Your pet is being sent home with a Fentanyl patch to help control pain. Fentanyl is a potent
drug. and it is important that you understand a little about it.
Fentanyl:
>- Fentanyl is a narcotic analgesic, which means that it is a morphine like dmg. ft
is used to control severe pain which is unresponsive to milder drugs and which
is expected to last more than a few days.
The Patch:
j;> The patch is designed to release a constant amount of fentanyl throngh the skin
into the bloodstream every hour. rt takes abont twelve bours to reach therapeutic
blood levels, and the e±leets last for about 72 hours.
j;> Although the patch will not lose it efficacy ifit comes into contact with water,
we recommend that you check with your veterinarian before bathing your pet.
y Heat may increase the mTIOllnt of fentanyl released by the patch, which may lead
to severe side effects from the drug. Hence we would recommend that you not
allow your pet to sleep on a electric blanket, heating pad, heated waterhed or
allow your pet to spend a lot of time outdoors or in a closed vehicle during the
hottest part of the day. If your pet develops a fever. please seck veterinary
advice immediately.
Side effects:
r Slow, shallow or difficult breathing

? Severe sedation (may be worsened by using other sedative drugs at the same
time, so check with your veterinarian about possible drug interactions)
>- Excessive scratching, licking and chewing
Management of the Patch:
? Fentanyl is a schedule [] controlled drug, which means that its usc is highly
regulated by the DEA, and because of its abuse potentiaL it is most important
that you take the management of the patch very seriously.
? Check frequently (several times daily) to be cert.ain that the patch is still in
place.
j;> Do not allow children or strangers to touch the patch (it may be prudent to keep
children away from the pet while the patch is in place)
? If you suspect your child or pet has ingested the patch, seek immediate medical
or veterinary advice.
rAfter 72 hours, carefully remove the patch. There may be some active drug
remaining in the patch. and so it is important that it not get into tbe wrong hands.
There arc several appropriate methods for disposal.
Take the patch to your veterinarian
Take (he patch to your phamlacist
Cut the into small pieces and flush down the toilet
your hands after removing the patch.
·234 -
Soal(er Catheter Notes from Dr. Kechia Davis, former lecturer SAS
1. Drug: Bupivicaine 0.25%

-Comes in SOml multi-dose vial, available in pharmacy or through
anesthesia.
-I will NOT use open vials from anesthesia and will either have them
open a new vial for me from their stock for the first loading dose in the
OR - or - if I'm on my game, I'll order a bottle for the patient prior to
surgery and bring it into the OR. Either way, the patient gets their very
own new bottle and there is no risk of cross-contamination. They keep
this vial with them in Recovery/lCU. IT's really cheap (i think S7 per
SOml vial). Most animals only need one vial per entire visit.
-1 rarely use the 0.7S% Bupivicaine* that anesthesia has because it is
more concentrated and expensive and the volume is usually too low to
give an adequate spray. *Bupivacaine 0.7S% ~ Dextrose 8.2S%
When ordering bupivicaine from pharmacy, just order the whole bottle
and not individual doses. Again, it is cheap and there is some concern
that individually loaded syringes may be accidentally given IV. This can
be fatal (obviously). Also, it assures that you are giving a sterile product
(at least initially). And r usually put a wear gloves sign on the cage and
on the orders just to remind people.
-Kechi a
2. Dose:
~ats: No more than 2mg/kg/day. In older cats, cats with heart or liver
problems, I will sometimes use Img/kg/day. O.Smg/lcg/dose has no
apparent CV affect on normal cats
P-W"; No more than 4 mg/lcg/day. Most large dogs get <2mg/lcg/day
because of volume issues (see below)
Take the daily dose and divide by 3 or 4 and give every 6-8 hours.
usually give every 6 hours for the first 24 hours, then every 8 the next
day (with the same volume so that you arc essentially tapering the dose),
then every12h the next if needed.
- 23S -
3. Volume:
Tusually do NOT exceed 10ml per dose regardless of the maximum dose
they may receive. I find that when I give more than 10ml/dose, they get
awful seromas. I Also tly to load them prior to leaving the OR to give me
an idea ofwbat volume to give while l'm staring at the incision. If the
volume I put in looks like it may be too much, I'll drop the volume on
the orders to a more appropriate amount (so instead of lOml, give 5) to
avoid seroma/leakage. Apparently, volume, not actual dose helps
determine regional efficacy in soaker catbs (see Dr. Johnson for further
details ).
4. Timing:
In the OR, try to give the first dose 20 minutes prior to when you think
the animal is going to be extubated. I try to give the first dose before the
towels are off. If I wait until they hit ICU .. they usually wake up
screaming and then I'm playing catchup. If I don't have a full 20 minutes,
I mix in a little lidocaine so that they have coverage until the marcaine
works. Make sure to drop that initial dose ofbupivicaine accordingly if
you add lidocaine to avoid toxicity.
5. Suturing in:
After many trials and errors at NCSU, the attached photo is the best way
we've found to secure these. They cycle and break with just lingertraps.
* sorry no photo included with this-- check with SAS
-viable options for suturing:
1. purse string + fingertrap + tape as shown in picture. They can kink
and break in the fingertrap if the fingertrap is too tight FYI
2. Purse string + tape as shown in picture with NO fingertrap. We've
tried these for the last 2 and it works nicely. Just make sure to tape right
whcrc thc cathcter exits the skin so it won't loop out.
] highly advise taping as shown in the picture or using option #2 - as I've

seen many many many other methods fail. BUT if you develop
something cooler that works, send me a pic.
6. Bandaging:
Not needcd for the soaker caths (especially in cats!) as seen in the
picture unless you need the bandage for something else. I highly advise
suturing the catheter in as shown in the pic EVEN IF YOU place a
- 236-
bandage. The filter is pretty heavy and will kink the catheter under the
bandage.
That's it. Let me know if you have any other questions. I'm thrilled you
guys are using these. Also, if you have any complications, send me an
email. I like to keep a running list. Complications I've seen so far:
1. Catheter sutured into the wound in sx. I haven't done this since my
new initials, but I have done it once. Trust me, you'll only do it once.
2. Dog chewed out cath
3. Cath breaks at interface between leur stub (that needle end that you
attach the tilter to) and the actual catheter. Good taping/suturing avoids
this.
4. Dozens of catheter kinks/breaks (outside ofthe wound) from
inadequate taping (method in pies avoids this for the most part)
Kechia Davis, DVM, DACVS

Lecturer
Small Animal Surgery
< 237 <

Diets and Iron Supplementation

Alternative low fat recipe for cats with pancreatitis (28%en):
1 pkt Vivonex TEN (300 kcal)
ISO ml X.S% parenteral Amino Acids
2S0 mg Taurine
Make up to 300 ml with water
Deliver at 7 ml/hr to deliver 200 kcallday
Ferrous sulfate: IS mg/kg/day (S mg/kg/day iron, lmg iron/kg/%

increase in PC). Problems with gastric irritation are probably
exaggerated. Continue for 6 months to replace storage iron. Equivalent
Pet-Tinic dose = 0.3 ml/kg/day
Iron Dextran: 0.02 ml/kg/% deficit in PC. Half as much again is needed
to replace storage iron. To replace 10% deficit in 10 Ib pup would require
0.2S ml daily for 4 days. Has induced sarcomas in lab animals. Can cause
anaphylaxis especially if given IV. Painful 1M.
- 238 -
Energy Requirements:
Dogs and Cats (Submitted by Dr. Hill)
UF Definitions (dogs)
(in, 9/1000 kCQI ME)
V. Low Low Mod!'. High,
Pro-tein <30 30.. 60 60 ... 90 >90
Fot <25 30-40 >50
Ce/P 1... 1.5 3 >5
Ne <0.5 0.5-1 1... 2 >2
- 239-
Estimated Mean Resting Fed Energy

Requirements of Dogs in Cages
2~0r-~==~===========c======~-, BCS
2000 <519
1&00 819
>; 1&00 719
1119
:Eiii 919
!
a:
~
1%
o 5 10 15 ~ 25 3(l 35 40 45 50 55 60 65 70
Current Body Weight (kg)
:VIeau Daily Energy Requirements of D{}gs and Cats

EndofPrcgmln<J· u , r.m~pcak J."tatkm J.4 .lIm~Strc." I.I, r.mR
3000
2aoo
non
2400
2200
i 2000
1:l 1800
:;; 1600
j 1400
- 1200
ffi 1000
:::E 800
600
ADO
200
o
10 15 20 25 30 35 40 45 50 55 6~
Body we ig ht(kg)
- 240 -
TPN Calculation Sheet
Energy Requirement
1) Dogs (cage rest) = 1500 x BSA kcal/day (BSA= body surface area in
meters from the meter-squared tables at the back of student formulary) or
use a graph.
Cats: 200 kcal (150-300) kcal/day Daily Requirement = .................. kcal
2) Allowance for stress: You may increase these estimates by 25% but it
is better to be conservative initially as it is easy to kill from over feeding.
Daily Requirement = .................. kcal
3) Amount of standard TPN solution in ml is about the same as energy

requirement in kcal because standard TPN contains"" I kcal/ml.
Total Daily Requirement = .................. ml
Rate of Delivery: divide total ml by 24 = ............. mllhr

Use half rate for first and last 6 - 24 hrs = ............. ml/hr
Rate of delivery should be adjusted up or down to suit animal's response.

The standard solution is then delivered in constant proportions. The
standard mixtures below are easier for preparation by the pharmacist.
May order TPN to make up several days at a time (to use up contents of
bottle or bag with minimal waste).
Standard Mixture Dog Dog Dog Cat

Ingredients 100b 30lbs 50lbs 8lbs
8.5% Amino Acids with elec. 200ml 500ml 700ml 150ml
50% Dextrose 100ml 250ml 350ml 60ml
20% Lipid Emulsion 50ml 125ml I 75ml 30ml
Concentrated Trace Minerals O.1ml 0.2ml O.3ml 0.05ml
± Heparin (1000 IU/ml) O.3ml Iml Iml 0.2ml
± 10% Calcium Gluconate (pm) 3m1 8ml 12ml 2ml
Vitamins (9+3) (add fresh daily) 2ml 4ml 6ml Iml
Total energy (kcal) 340 850 1200 210

Delivery rate (ml/hr) 14 35 50 10
- 241 -
This mixture contains:

Dog: 20% protein; 50% carbohydrate; 30%en fat, 40 mEqlL sodium, 34
mEq/L potassium, 40 mEqlL chloride, 6 mEqlL magnesium, 19 mmollL
phosphate, 80 mEq/L acetate.
Cat: 48% carbohydrate; 28% fat, 44 mEq/L sodium, 37 mEqlL

potassium, 44 mEq/L chloride, 6 mEqlL magnesium, 21 mmol/L
phosphate, 107 mEqIL acetate.
Both ± 5 mEqlL calcium, 1 mglL zinc, 0.2 mg/L copper, 0.1 mg/L
manganese, 21lg/L chromium, 121lg/L selenium, 15 IlgIL iodide, 1650
IU/L vit A, 100 IUIL vit D, 5 IUIL vit E, 50 mglL vit C, 1.5 mglL vit B),
1.8 mgIL B2, 20 mg/L B 3, 2 mg/L B6 , 2.5 mg/L B 12 , 7.5 mg/L
pantothenic acid, 200 IlglL folate.
- 242-
University of Florida .............................. " ..... ". Veterinary Medical Center
TPN Completed Prescription Examples
PRESCRIPTION
VEniRINARY MFDICAL CENTER
UNIVERSITY of FLORID,\
2i11, SW 16" AVENUE SMALL .i\N'IMA1. c1J:-.IIC ph0l1C 3~2/.i9Z"410{j ex!. 48-20
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··243 -
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UNIVERSITY nf F1 DRlnA
2015 SW 16'" AVENUt~ SMALL ANIMAL ('UNIC phort.£' ~:"i2./:lo92-4_700 ext 482.0
GAINESV1ILE. FLORIDA ,1,2t)lO _ T.A.RGE ANIMAL. cr -INIC' phone ;:S:::2B92-4700exL ~non
OUTPAT\\iNlrNI~'l DISCHARGLc 1 5"_~.~1~7 CI:;;;r'
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CHARGE
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EXP. DATE/LOT NO
EXP. DATE/LOT NO
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- 244-
PRESCRIPTION
VETERINARY MEDICi\L CENTER
UNIVERSITY of FJ.ORlDA
:2Ul~ SW 16'" AVENUE SMALL ANIMAl, CI.lNlC pholle! :ti2J392-4700 ~xr. 4t)20
GAINESVILLE. FWIUI>A 32610 LARGE ANIMAL CUNIC pbo"e 352!39Z·4700 ext. 3000
I OUTPATIENT \ 'INHO~i
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lH~U~.,. -:;T(Hll .
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'CHARGE
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EXP, DA'rE/LOT NO,
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PRESCRIPTION NO.
R
CHARGE
EXP. DATE/LOT Ne)'
o REHLLABLli _ __
SERVICE STUDENT
Wbile-Phatmft(!)' YeU('IW-C!ient
·245 -
INDEX
2
2-PAM, - 168 -
3
3V FREE FORM LIQUID, - 88 -
4
4-methylpyrazole, - 97 -
A
Acepromazine maleate, - 9 -
Acepromazine maleate PROMACE, - 9 -
Acetazolamide, - 9 -
Acetic Acid 2%, Boric Acid 2% with surfactants, - 9 -
Acetylcysteine, - 10 -
Acetylsalicylic Acid, - 26 -
ACTH (aka Cosyntropin), - 10 -
ACTIVASE, - 13 -
Acyclovir, - 11 -
ADEQUAN CANINE, -165-
ADEQUAN 1M, - 165-
Adhesive, - 11 -
Adrenalin Chloride, - 82 -
ADRIAMYCIN, - 75 -
ADVANTAGE, - 107 -
ADVANTAGE MULTI for CATS, - 108 -
ADVANTAGE MULTI for DOGS, - 109 -
ADVANTIX, - 110-
ALBON, - 189-
Albumin (Human), - 11 -
- 246-
Albuterol, - 12 -
Allergenic Extract, - 177 -
Alprazolam, - 13 -
Alteplase, - 13 -
Altrenogest 0.22%, - 13 -
Aluminum Hydroxide Gel, - 14 -
AMIDATE, - 86 -
AMIGLYDE-V, - 14-
Amikacin, - 14 -
Aminocaproic Acid, - 15 -
Aminophylline, - 16 -
Amiodarone HCI injection, - 16 -
Amitriptyline Hel, - 17 -
Amlodipine, - 18 -
Ammonium Chloride Powder, - 18 -
Amoxicillin, - 19 -
Amoxicillin with Clavulanic Acid, - 19 -
AMOXI-DROP, AMOXI-TAB, - 19-
Amphotericin B, - 20 -
Ampicillin, - 20 -
Ampicillin sodium with sulbactam sodium, - 21 -
ANASED, - 209 -
ANIMAX, - 149-
ANIPRYL, - 182-
ANTIROBE, - 51 -
ANTISEDAN, - 27 -
Antivenin (Crotalidae), - 22 -
Antivenin (Crotalidae) Polyvalent, - 23 -
Antivenin Coral Snake, - 22 -
ANTIZOLE-VET, - 97-
Apomorphine, - 24 -
ARANESP, - 60 -
Artificial Tears Gel, - 24 -
- 247-
University of Florida ........................ "............... Veterinary Medical Center
Artificial Tears Ointment, - 25 -

Artificial Tears Solution, - 24 -
ASA, - 26-
Ascorbic Acid, - 25 -
Aspirin, - 26 -
Atenolol, - 26 -
Atipamezole, - 27 -
ATOPICA, - 56-
Atracuriml1 Besylate, - 27 -
Atropine] % Sulfate Ophthalmic, - 28 -
Atropine Sulfate Injection, - 27 -
Azathioprine, - 28 -
Azithromycin, - 29 -
B
Bacitracin, Neomycin, Polymyxin B, - 30 -
Bacitracin, Neomycin, Polymyxin B, Hydrocortisone 1%, -
30 -
BAL in OiL - 69 -
BANAMINE, - 94 -
BAYTRIL, - 79 -
BENADRYL, -70-
Benazepril HCI, - 30 -
Benzocaine 14%, Butyl Aminobenzoate 2%, Tetracaine HC]
2%, - 30-
Benzoic, Malic, Salicylic Acid, - 31 -
Benzoyl Peroxide 2.5%, - 31 -
Benztropine mesylate, - 31 -
Bethanechol Chloride, - 32 -
BEUTHANASfA-D SPECIAL, - 155 -
Bifidobacterium animalis, - 32 -
BIO-SPONGE, - 71 -
Bismuth Subsalicylate, - 33 -
- 248 -
Bismuth Subsalicylate l.75%, - 33 -

Bitter Apple, - 46 -
BRETHINE, - 191 -
Bupivacaine 0.25%" - 34 -
Bupivacaine HCI 0.75%, Dextrose 8.25%, - 34 -
Buprenorphine, - 34 -
BUSCOPAN, - 36 -
Butorphanol, - 35 -
butylscopolammomium bromide, - 36 -
C
C.E.T. Poultry Flavored, - 195 -
Caffeine, - 36 -
Calcitonin-Salmon, - 36 -
Calcitriol, - 37 -
Calcium Borogluconate 23%, - 38 -
CALCIUM DISODIUM VERSENATE, - 77 -
Calcium Glubionate, - 38 -
Calcium Gluconate, - 38 -
CAL-NATE 1069, - 38 -
CAPSTAR, - 146-
CARAFATE, - 188-
CARBOCAINE-V, - 131 -
Carboplatin, - 39 -
CARDIZEM, - 68 -
Carprofen, - 39 -
CCND, -124-
CEEND, - 124 -
CEFA-DROPS, - 40 -
Cefadroxil, - 40 -
CEFA-LAK, - 45-
CEFA-TABS, - 40-
Cefazolin Sodium, - 40-
- 249-
Cefepime, - 41 -
Cefotaxime, - 41 -
Cefovicin, - 42 -
Cefoxitin, - 42 -
Cefpodoxime proxetil, - 43 -
Ceftazidime, - 43 -
Ceftiofur Sodium, - 44 -
Cephalexin, - 45 -
Cephapirin Sodium, - 45 -
CEPHULAC, - 120 -
CERENIA, - 128-
CETACAINE SPRAY, - 30-
Charcoal Activated, Sorbitol, Kaolin, - 46 -
Chew Stop, - 46 -
Chlorambucil, - 46 -
Chloramphenicol, - 47 -
Chloramphenicol Ophthalmic, - 47 -
Chlorhexidine, - 48 -, - 49 -
Chlorhexidine gluconate, - 49 -
Chlorpromazine HCI, - 50 -
Chorionic Gonadotropin, - 50 -
CHORULON, - 50 -
CHRONULAC, -120-
Ciprofloxacin 0.3% Ophthalmic Solution, - 50 -
Citmlline, - 51 -
CLAFORAN, - 41 -
Clarithromycin, - 51 -
CLAVAMOX, - 19-
Clindamycin, - 51 -
CLINICARE CANINEIFELINE Liquid Diet, - 81 -
CLINTABS, - 51 -
CLOMICALM, - 52 -
Clomipramine, - 52 -
- 250-
University of Florida .................... " .................. Veterinary Medical Center
Clostridium Botulinum (Polvvalent) Antitoxin, - 51 -

Clotrimazole 1%, - 52 -
Cobratoxin, - 53 -
COGENTTN, - 31 -
Conoidal Oatmeal, - 53 -
Colon Electrolyte Lavage Solution, - 53 -
COL YTE, - 53 -
COMFORTIS, - 186 -
CONOFITE, - 136 -
CONVENIA, - 42 -
Copper Naphthenate 37.5%, - 54 -
CORTROSYN, - 10 -
CO SEQUIN, - 101 -
COSEQUIN DS, - 101 -
COSMEGEN,- 59 -
CROFAB, - 22 -
CUPRIMINE, - 154 -
CUPRINOX, - 54 -
Cyanocobalamin, - 54 -
Cyclophosphamide, - 54 .-
Cvclosporine, - 56 -
Cyclosporinc 0.2% Ophth Ointment, - 57 -
Cyproheptadine, - 57 -
CYSTORELIN, - 102 -
Cytarabine, - 58 -
CYTOSAR-U, - 58 _.
Cytosine Arabinosidc, - 58 -
CYTOTEC, - 140 -
D
D.A.P., - 161 -
Dactinomycin, - 59 -
DANTRIUM, - 59 -
- 25] -
Dantrolene, - 59 -
DARAPRIM, - 176 -
Darbepoetin Alfa, - 60 -
DEMEROL - 131 -
DENOSYL SD4, - 181 -
DEPO-MEDROL, - 134 -
Deracoxib, - 60 -
DERAMAXX, - 60 -
DERMA-CLENS, - 31 -
DERMAL SOOTHE RINSE, - 168 -
DERMAL SOOTI-IE SHAMPOO, - 168-
DERMAL SOOTHE Spray, - 168 -
Deslorelin Implant, - 61 -
Desmopressin Acetate Inj, - 61 -
Desoxycorticosterone Pivalatc, - 61 -
Detomidine, - 62 -
Dexamethasone, - 62 -
Dexamethasone sodium phosphate, - 62 -
DEXDOMITOR, - 63 -
Dexmedetomidine, - 63 -
Dexrazoxane, - 64 -
Dextrose, - 64 -
DHT, - 68-
DIAPER RASH OINTMENT, - 210-
Diazepam, - 65 -
Dicalcium Phosphate Powder, - 66 -
Diclofenac 0.1 %, - 66 -
Diclofenac 1%, - 66 -
Digoxin, - 67 -
Dihydrotachysterol, - 68 -
Dihydroxycholecalciferol, - 37 -
DILACOR XR, - 68 -
Diltiazem, - 68 -
- 252 -
DimQrC:§.PL()L - 69 -
Dimethyl Sulfoxide, - 69 -
Dinoprost tromcthaminc, - 70 -
Dioctyl Sodium Sulfosuccinate, - 72 -
Diphenhydramine HCL, - 70 -
Diphenoxylate, atropine, - 71 -
Dipotassium EDT A, - 71 -
Di-tri-octahedral (DTO) smectite, - 71 -
DMSO, - 69-
Dobutamine, - 72 -
DOBUTREX, -72-
Docusate Sodium, - 72 -
DOMITOR, - 129-
DOMOSO, - 69 -
Domperidone, - 73 -
Dopamine HCL, - 73 -
DOPRAM V, -75 -
DORMOSEDAN, - 62 -
Dorzolamide 2%, - 74-
DOUBLE ANTIBIOTIC OINTMENT, - 164-
Doxapram HCL, - 75-
Doxorubicin, - 75 -
Doxycycline hyclate, - 76 -
DRONCIT, - 169 -
DSS, - 72-
DURALACTIN, - 137 -
E
Edctatc calcium disodium, - 77 -
Edrophonium Chloride, - 78 -
EDTA, -77-
Electrolyte§., Oral, - 78 -
ELSP AR, - 25 -
- 253 -
University of Florida ..... " ................................ Veterinary Medical Center
ENACARD, - 79 -
Enalapril, - 79 -
ENLON, -78-
Enrofloxacin, - 79 -
Enteral Nutrition, - 81 -
EPA, - 88-
Ephedrine Sulfate, - 82 -
Epinephrine HCl, - 82 -
EPI-OTIC, - 120 -
Epoetin Alpha, - 83 -
Epsom Salts, - 126 -
EQUALIZER, - 83 -
EQUID ONE, - 73 -
EQVALAN, - 116-
Erythromycin, - 83 -
E-SE, - 207 -
Esmolol, - 84 -
Ethiodized Oil, - 85 -
ETHIODOL, - 85 -
Ethyl Lactate 10%, - 85 -
Ethylenediamine DihyQroiQ.Qid~, - 86 -
ETlDERM Shampoo, - 85 -
Etodolac, - 86 -
ETOGESIC, - 86 -
Etomidate, - 86 -
F
Famotidine, - 87 -
Fat Emulsion, - 87 -
Fatty Acids Dietary Supplement, - 88 -
Fenbendazole, - 88 -
Fentanyl, - 89 -
Ferrous sulfate, - 90 -
- 254 -
Filgrastim, - 91 -
Fipronil, - 91 -
Firocoxib, - 92 -
Florfenicol, - 93 -
FLOVENT, - 97 -
Fluconazole, - 93 -
Fludrocortisone Acetate, - 93 -
Flumazenil, - 94 -
FLUNIXAMINE, - 94-
Flunixin Meglumine, - 94 -
Fluocinolone acetonide DMSO, - 94 -
Fluorescein Sodium, - 95 -
Fluorouracil, - 95 -
Fluoxetine, - 96 -
Flurbiprofen 0.03% Ophth Soln, - 96-
Fluticasone Propionate Inhaler, - 97 -
FLYPEL Spray for Horses, - 157 -
Fomepizole, - 97 -
FORTAZ, - 43-
FRONTLINE PLUS, - 91 -
FRONTLINE SPRAY, - 91-
Furosemide, - 97 -
G
Gabapentin, - 98 -
GASTRO-COTE, - 33 -
GASTROGARD, - 149-
GENESIS TOPICAL SPRAY, - 197-
Gentamicin, - 99 -
Gentamicin Sulfate 0.3% Ophthalmic, - 100 -
Gentamicin sulfate 0.3%, Betamethasone 0.1 % Otic
Solution, - 100 -
GENTEAL GEL, - 24 -
- 255 -
Glucagon, - 100 -
Glucosamine Hel, Sodium Chondroitin Sulfate, Manganese
Ascorbate, - 101 -
Glycerin, - 101 -
Glycopyrrolate, - 101 -
Gonadorelin, - 102 -
Guaifenesin, - 102 -
H
RCG, - 50-
HEARTGARD, - 116 -
HEARTGARD For Cats, - 116-
HEARTGARD-PLUS, - 116 -
Hemoglobin Glutamer 200 (bovine), - 102 -
Heparin Sodium Injection, - 103 -
Hetastarch 6% in 0.9% Sodium Chloride, - 103 -
Hyaluronate Sodium, - 103 -
HYCODAN, - 104 -
Hydralazine, - 104 -
Hydrocodone Bitartrate, - 104 -
Hydrocortisone 1%, - 105 -
Hydrocortisone 1% Conditioner, - 105 -
Hydrocortisone sod. succinate injection, - 105 -
Hydrogen Peroxide 3%, - 106 -
Hydromorphone, - 106 -
Hydroxvzine, - 106 -
HYLARTIN V, - 103-
HYL YTefa SHAMPOO, - 107 -
Hypo-Allergenic Shampoo, - 107
Imidacloprid 10% + Moxidectin J %, - 108 -

Imidacloprid 10% + Moxidectin2!.5%, - 109 -
- 256 -
Imidacloprid 9.1 %, - 107 -

Imidacloprid 9.1 %, Permethrin 44%, - 110 -
Imipenem-Cilastatin, - 111 -
Imipramine, - 112 -
IMMITICIDE, - 129 -
Immune Globulin (Human), - 112 -
IMURAN, - 28 -
INFUVITE, - 204 -
Insulin, - 112 -
INTERCEPTOR Flavor Tabs, - 138 -
INTRALIPID 20%, - 87 -
Iodide, - 86 -
Iodine Tincture, strong, - 114 -
Iron dextran, - 114 -
ISOFLO, - 115 -
Isoflupredone acetate, - 115 -
Isoflurane, - 115 -
Isoproterenol HCI, - 115 -
Isoxsuprine, - 115 -
ISUPREL, - 115 -
Itraconazo1e, - 116 -
Ivermectin, - 116 -
IVOMEC, - 116-
K
Ketamine, - 118 -
Ketoconazo1e, - 118 -
KETOFEN, - 119-
Ketoprofen, - 119 -
KILTIX, - 156 -
KNOCKOUT AREA TREATMENT, -176-
KNOCKOUT with Nylar, - 157-
KONSYL, - 175 -
- 257-
KOPPERTOX, - 54 -
L
LA 200, - 151 -
LACTAID ULTRA, - 120-
Lactase enzyme, - 120 -
Lactic Acid, Salicylic Acid, - 120 -
Lactulose, - 120 -
LANOXIN, - 67-
L-Asparaginase, - 25 -
Latanoprost, - 120 -
Laxative, - 121 -
LAXATONE, - 121 -
LEGEND, - 103 -
LEUKERAN, - 46 -
LEVOPHED, - 148-
Levothyroxine, - 121 -
Lidocaine 2% HCI, - 122 -
Lidocaine 2.5% and Prilocaine 2.5% Cream, - 122 -
Lidocaine 5% Patch, - 123 -
LIDODERM, - 123 -
Lime Sulfur 97.8% Concentrate, - 123 -
UNCOCIN, - 124-
Lincomycin HCl, - 124 -
Lomustine, - 124 -
Loperamide HCI, - 124 -
LOTENSIN, - 30-
Lufenuron, - 125 -
LUT ALYSE, - 70 -
LymDYP, - 123 -
LYSODREN, - 141 -
- 258 -
M
MACRODANTIN, - 147 -
Magnesium Sulfate, - 126 -
Magnesium Sulfate 50% Injection, - 126 -
MALACETIC OTIC FLUSH, - 9 -
MALACETIC Wet Wipes/Dry Bath, - 9-
MALASEB Pledgets, - 119 -
Mannitol, - 126 -
Marbofloxacin, - 127 -
M~TNE LIPID CONCENTRATE, - 88 -
Maropitant, - 128 -
MARQUIS Paste, - 165 -
MAXIPIME, - 41 -
Medetomidine, - 129 -
Melarsomine, - 129 -
Meloxicam, - 130 -
Meperidine HCI, - 131 -
Mepivacaine, - 131 -
MESTINON, - 176 -
METACAM, - 130-
Methadone, - 131 -
Methazolamide, - 132 -
Methimazole, - 132 -
Methocarbamol, - 132 -
Methotrexate, - 133 -
Methylene Blue, - 134 -
Methylprednisolone Acetate, - 134 -
Methylprednisolone Sod. Succ, - 134 -
Metoc1opramide, - 135 -
Metronidazole, - 135 -
Mexiletine, - 136 -
MIACALCIN, - 36 -
Miconazole, - 136 -
- 259 -
University of Florida .... " ........... " ................. " .. Veterinary Medical Center
Miconazole. chlorhcxidinc gluconatc, - 119 -

MicroLactin, - 137 -
MICROPEARLS BENZOYL PLUS SHAMPOO, - 31 -
Midazolam, - 137 -
Milbemycin Oxime, - 138 -
Milbemycin Oximc/Lufenuron, - 139 -
Milk Thistle Seed Extract, - 139 -
Milrinone, - 140 -
Misoprostol, - 140 -
Mitotane, - 141 -
MONISTAT 7, - 136-
Morphine Sulfate, - 141 -
Moxidectin 2%, - 142 -
Moxidectin 2%, Prazi.mlanteIJ2.5%, - 142··
MUCOMYST, - 10 -
MUL TITRACE-4 Concentrate, - 196 -
Mupirocin 2% Ointment, - 143 -
MURO 128, - 185 -
MU-SE, - 207 -
Mycobacterium Cell Wall Fraction (BCG), - 143 -
N
Naloxone HCL, - 143 -
NATACYN, - 144
Natamycin, - 144 -
NAXCEL, - 44 -
NEMBUTAL, - ]55-
Neomycin Sulfate, - J44 -
Neomycin, Polymyxin E, Dexamethasone 0.1 % Ophthalmic,
- 145-
Neomycin, Polymyxin B. Gramicidin Ophth Solution, - 145 -
Neomycin, Polymyxin B, Hydrocortisone 1% Otic Solution,
- 145 -
- 260 -
University of Florida ..... " ...... " .... "" .......... " ... " Veterinary Medical Center
NEORAL - 56-
Neostigmine Methylsulfate, - 146-
NEUPOGEN, - 91 -
Nitenpyram, - 146 -
Ni trofurantoin macrocrystals, - 147 -
Nitrofurazone Soluble Dressing, - 147 -
Nitroglycerin Ointment 2%, - 147 -
NITROPRESS, - 148 -
Nitroprusside, - 148 -
NOLVASAN, - 48-
Norepinephrine bitartrate, - 148 -
NORVASC, - 18-
NUFLOR, - 93 -
NUTRI-CAL, - 206 .-
Nystatin, - 149 -
Nystatin, Neomycin Sulfate, Thiostrepton, Triamcinolone
Acetonide, - 149 -
o
o,p'-DDD, - 141 -
OIVrEGA-3 EPA, - 88 -
Omeprazole, - 149 -
Ondansetron, - 150 -
Ophthalmic Irrigation Solution, - 150 -
OPTIMMUNE, - 57 -
OVUPLANT, - 61 -
OXYGLOBIN, - 102 -
Oxytetracycline base, - 151 -
Oxytetracycline HCI, - 151 -
Oxytetracycline, Polymyxin B sulfate Ophthalmic Ointment,
- 151 -
Oxytocin, - 152 -
··261 -
P
Pamidronate disodium, - 152 -
PANACUR, - 88 -
PANACUR C, - 88-
Pancreatic Enzymes, - 153 -
PANCREZYME, - 153 -
Pancuronium Bromide, - 153 -
PANMYCIN, - 191 -
PARAPLATIN, - 39 -
Penicillamine, - 154 -
Penicillin G Potassium, - 154 -
Penicillin G Procaine, - 154 -
Penicillin G, Procaine/Benzathine, - 155 -
Pentobarbital, - 155 -
Pentobarbital, Phenytoin, - 155 -
PENTOTHAL, - 193 -
Pentoxifylline, - 156 -
PEPCID, - 87 -
PEPCID AC, - 87 -
PEPTO-BISMOL, - 33 -
PERCORTEN-V, - 61 -
Permethrin 2%), - 157 -
Permethrin 2%, Pyriproxyfen 0.05% Spray, - 157 -
Permethrin 45%, - 156 -
Petrolatum White, - 158 -
PET-TABS, - 208-
PET-TINIC, - 208-
Pharyngeal Flush Solution, - 158 -
Phenobarbital, - 158 -
Phenoxybenzamine, - 159 -
Phentolamine mesylate, - 159 -
Phenylbutazol:}~, - 160 -
Phenylephrine, - 160 -
- 262-
University of Florida " .... " ..... " ........ " ... " ........ " Veterinary Medical Center
Phenvlenhrine 0.5% Nasal Spray, - 161 -

Phenylephrine Ophthalmic Solution, - 161 -
Phenylpropanolamine HCL, - 161 -
Pheromone, Dog Appeasing, - 161 -
Phytonadione, - 162 -
Pilocarpine, - 163 -
Pimobendan, - 163 -
Piroxicam, - 163 -
Poloxalene Drench, - 164 -
Polymyxin B Sulfate, - 164 -
Polymyxin B, Bacitracin Ointment, - 164 -
Polymyxin B, Bacitracin, Neomycin Ointment, - 164 -
Polysulfated Glucosaminoglycan, - 165 -
Ponazuril 15%, - 165 -
Potassium Bromide, - 165 -
Potassium Chloride Injection, - 166 -
Potassium Gluconate, - 166 -
Potassium Phosphate Injection, - 167 -
Povidone-Iodine, - 167 -
Pralidoxime Chloride, - 168 -
Pramoxine 1%, Novasome microvesicles, - 168 -
Pramoxine Hydrochloride 1%, Colloidal Oatmeal, - 168 -
PraziquanteI, - 169 -
PreDEF 2X, - 115 -
Prednisolone, - 170 -
Prednisolone Acetate 1%, - 170 -
Prednisolone Sodium Succinate, - 170 -
Prednisone, - 171 -
PREPARATfONH, - 171 -
PREVICOX, - 92 -
PRILOSEC, - 149 -
PRIMAXfN I.V., - 111 -
PRIMOR, - 189-
- 263 -
eniversity ofFJorida .... " ....... " ......................... Veterinary Medical Center
Procainamide HCL - 172 -

PROCRIT-2, - 83 -
PROGRAM, - ] 25 -
PROfN, - 161 -
PROMACE, - 9-
Proparacaine HCL 0.5%, - 172 -
PROPOFLO, - 173 -
Propofol, - 173 -
Propranolol, - 173-
Propylene Glycol, - 174 -
PROSTORA MAX, - 32 -
Protamine Sulfate, - 174 -
PROTOP AM, - 168 -
PSGAG, - 165 -
Psyllium Hydrophilic Muciloid Powder, - 175 -
Pyrantel Pamoate, - 175 -
Pyridostigmine, - 176 -
Pyrimethamine, - 176 -
Pyriproxyfen, Tetramethrin Area Treatment, - 176 -
Pythium Insidiosum, - 177 -
Q
QUEST GEL, - 142-
QUEST PLUS, - 142 -
Quinapril, - 177 -
Quinidine, - 177 -
R
Ranitidine, - 178 -
REBALANCE, - 189 -
RECONCILE, - 96-
REGU-MATE, - 13-
RemifentaniJ, - 179 -
- 264-
University of Florida" ..................... ,.......... ,.. ,.. Veterinary Medical Center
Reserpine, - 179 -
ResiCHLOR, - 48 -
ResiCORT Conditioner, - 105 -
ResiKetoChlor, - 49 -
ResiZOLE, - 136 -
RE-SORB, - 78 -
REVOLUTION, - 181 -
rhG-CSF, - 91 -
Rifampin, - 179 -
RIMADYL, - 39 -
ROBINUL-V, - 101 -
ROMAZICON, - 94 -
Romifidine HCl, - 180 -
S
s-adenosylmethionine, - 181 -
SALIX, - 97-
Salmeterol xinafoate, - 180 -
SAMe, - 181 -
SANDIMMUNE, - 56 -
SEDIVET, - 180-
Selamectin, - 181 -
Selegiline hydrochloride, - 182 -
SENSORCAINE - MPF SPINAL, - 34 -
SENTINEL Flavor Tabs, - 139 -
SEQUESTER-SOL, - 71 -
SEREV ENT Inhalation Aerosol, - ] 80 -
SEVOFLO, - 183 -
Sevof1urane, - 183 -
Sildenatil, - 183 -
SILVADENE, - 183-
Silver Sulfadiazine 1% cream, - 183 -
SlMPLlCEF, - 43 -
- 265 -
University of Florida ....... ., .............. ., ............... Veterinary Medical Center
SMZ-TMP, - 200-
Sodium Bicarbonate, - 184 -
Sodium Chloride, - 185 -
Sodium Chloride 5% Ophthalmic, - 185 -
Sodium Citrate, - 185 -
Sodium Hypochlorite, Sodium Thisulfate, - 186 -
Sodium Iodide 20%, - 186 -
SOLOXINE, - 121 -
SOLU-CORTEF, - 105-
SOLU-DELTA-CORTEF, - 170 -
SOLU-MEDROL, - 134-
Sotalol HCI, - 186 -
Spino sad, - 186 -
Spironolactone, - 187 -
SPORANOX, - 116-
STOMAHESIVE Paste, - 11 -
STRONGID T, - 175 -
Sucralfate, - 188 -
Sulfadiazine, Pyrimethamine, - 189 -
Sulfadimethoxine. - 189 -
Sulfadimethoxine, Ormetoprim, - 189 -
Sulfasalazine, - 190 -
SURFACE SAFE, - 186 -
SURPASS Cream, - 66 -
SYNOTIC, - 94-
T
T8 SOLUTION, - 201 -
Taurine, - 191 -
TAZICEF, - 43-
TELAZOL, - 194 -
TEMARIL P, - 199-
TENSILON, - 78 -
- 266 -
University of Florida", .................................. ,.. Veterinary Medical Center
Terbutaline, - 191 -
TERRAMYCIN, - 151 -
Tetracycline HCL, - 191 -
Theophylline anhydrous, - 192 -
THERABLOAT Drench Concentrate, - 164 -
Thiabendazole, Dexamethasone, Neomycin Sulfate, - 192 -
Thiamine HCl, - 192 -
Thiopental Sodium, - 193 -
Ticarcillin, - 193 -
Tiletamine, Zolazepam, - 194 -
Timolol, - 194 -
TIMOPTIC, - 194 -
Tobramycin 0.3% Ophthalmic Solution, - 195 -
Tocopherol, - 195 -
Toothpaste, - 195 -
TORBUGESIC, - 35 -
TORBUGESIC - SA, - 35 -
TORBUTROL, - 35 -
TOTAL FORMULA, - 208-
TOXIBAN,- 46 -
tpa, - 13 -
Trace Elements, - 196 -
TRACRIUM, - 27 -
Tramadol HeL, - 196 -
TRESADERl'vl, - 192 -
Triamcinolone 6.cetonid~, - 197 -
Triamcinolone Acetonide 0.015%, - 197 -
Trifluridine 1% Ophthalmic Solution, - 198 -
Trimeprazine, prednisolone, - 199 -
Trimethoprim, Sulfa, - 200 -
TRIOPTIC P, - 30-
TRIOPTIC S, - 30 -
TRIPLE ANTIBIOTIC OINTMENT, - 164 -
- 267 -
Triple Antibiotic Ophth Oint Plain, - 30 -

Triple Antibiotic Ophth Oint with Steroid, - 30 -
Triple Antibiotic Ophthalmic Solution, - 145 -
Tris-EDTA Otic Solution, - 201 -
Tropicamide 1% Ophthalmic Solution, - 201 -
TRUSOPT, - 74-
TUMIL K, - 166-
TUSSIGON, - 104 -
Tylosin Tartrate Powder, - 201 -
U
ULTIVA, - 179-
UNASYN, - 21 -
URECHOLINE, - 32 -
UROEZE, - 18 -
Ursodiol, - 202 -
v
Val acyclovir, - 202 -
VAL TREX, - 202 -
VASELINE, - 158-
Vasopressin, - 202 -
VASOTEC, - 79 -
VELBAN, - 203 -
VETALOG, - 197-
VETMEDIN, - 163 -
VIBRAMYCIN, - 76 -
Vinblastine, - 203 -
Vincristine, - 203 -
Vinorelbine, - 204 -
VIROPTIC, - 198 -
VITAL E - 300, - 195 -
Vitamin A and Vitamin D Ointment, - 205 -
- 268-
Vitamin A, D, E, B Complex, Folic Acid, - 206 -

Vitamin A, D3 Injection, - 205 -
Vitamin B Complex, - 206 -
Vitamin B 1, - 192 -
Vitamin B 12, - 54 -
VITAMIN C, - 25 -
Vitamin D, - 206 -
Vitamin E, - 195 -
Vitamin E 50 mg/mI, Selenium, - 207 -
Vitamin Kl, - 162 -
Vitamin, Mineral Supplement, - 208 -
Vitamin/Mineral Hypoallergenic Supplement, - 208 -
Vitamins for Infusion, - 204 -
VIVONEX PLUS, - 81 -
VOL TAREN, - 66 -
x
XALAT AN, - 120 -
XANAX, - 13 -
Xylazine, - 209 -
y
YOBINE, - 2] 0 -
Yohimbine, - 210 -
Z
ZANTAC, - 178-
ZENIQUIN, - 127 -
Zinc Oxide, Cod Liver Oil, Petrolatum Ointment, - 210 -
ZITHROMAX, - 29-
- 269 -
Notes
- 270-
Notes
- 271 -
Notes
- 272-

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University of Florida ........................................

Veterinary Medical Center

This formulary is intended for use by the students, faculty,

The Veterinary Medical Center makes no warranty with

The formulary is a tool designed to provide basic

The dosages included are meant to serve as a guide; do not

We can only provide one copy to each student at the

The formulary has been proofread many times; however

Sandy Still, Pharm.D., FSVHP

PHARMACY TALK - terms commonly used

SDV single dose vial; usually has no preservativcs - discard contents

MDV - multi-dose vial; has preservatives; may be used for multiple

DOSETTE vial- a small vial designed to provide one standard human

CARPUJECT - a long cylindrical vial with needle attachment designcd

AMPule - a sealed glass vial that must be broken at the neck to

Capsule -- a football shaped oral dosage form, usually containing drug in

Tablet - a solid dosage fonTI, manufactured by compressing powders

Caplet - a capsule-shaped tablet.

Pill - an "old fashioned" solid dosage form prepared by rolling

Bacteriostatic Diluent has preservatives and may provide the

drug - check the label! Likewise, benzyl alcohol is a commonly used

Preservative free diluent provides no protection to the reconstituted

Dose or Dosage - the amount of drug to be administered to the patient,

Misbranding - labeling a drug by a brand name is okay ONLYifyolJ

Abbreviations Used in Prescription Writing - DO NOT create your

Index .................................................................................. 246

Notes ................................................................................. 270

Acepromazine maleate PROMACE

USE: Phenothiazine tranquilizer

Horse: 0.1 mg/kg IV, 1M, SQ for heavy sedation 0.04 to

FORMULATION: 10 mg (pink) and 25 mg (yellow) tablets; 10

NOTE: 1. Phenothiazines can precipitate seizures in epileptic animals,

USE: A non-bacteriostatic sulfonamide that inhibits carbonic

DOSE: Horse: 2 to 5 mg/kg PO BID to QLD.

FORMULA TION: 250 mg tablet

Acetic Acid 2%, Boric Acid 2% with surfactants MALACETIC Otic

USE: An ear/skin cleanser.

FORMULATION: Otic flush, apple scent - 4 and 16 oz bottles; wipcs

Acetylcvsteine MUCOMYST, generics

USE: Mucolytic; antidote to acetaminophen toxicity

DOSE: Ophthalmic: 20% solution diluted to 10% with artificial tears;

FORMULATION: 20% solution, NOT FOR INJECTION in 10 ml

NOTE: Per manufacturer instructions - stable for 96 hours after opening

ACTH (Cosyntropin) CORTROSYN

USE: Diagnostic test for adrenocortical insufficiency, pituitary

DOSE: Dog, Cat: Body weight> 10 lb - give 0.25 mg I V or

FORMULA nON: 0.25 mg per vial (single dose); dilute with 1 ml

NOTE: 1. HUMAN PRODUCT

USE: An antiviral agent.

FORMULA TION: 800 mg tablet

NOTE: 1. HUMAN PRODUCT

Adhesive STOMAHESIVE Paste

USE: Adhesive used to seal dressings for wound management with

FORMULATION: 2 ounce tube

USE: A natural colloid used clinically as a volume expander

DOSE: For IV administration only in dogs.

FORl'vlULATlON: 25% solution in ]00 ml bottle (contains 96'%

USE: Indicated for treatment of hypovolemic shock or

DOSE: Hypovolemic shock: Dilute to 16% and administer IV at a fate

Hypoalbuminemia: Dilute to 1G% and give a total of 5-6ml/kg.

FORMULA nON: Canine albumin 5gm lyophilized powder in vial

Notes fiJT reconstitution:

Concentration Amount of Diluent

USE: Bronchodilator (beta-adrenergic) for symptomatic relief of