FBCA Biomarkers and Conditions

FUNCTIONAL BLOOD CHEMISTRY ANALYSIS
Biomarkers and Their Conditions
Introduction
There are few diagnostic tests that are truly diagnostic all on their own. It is important to see the trends and patterns that exist
between various tests. This guide is organized to provide that information by listing the individual biomarkers of the blood chemistry
screen and complete blood count. Beside each BIOMARKER, organized by high or low values, is a list of the most common
conditions seen with deviations from normal.
BIOMARKER HIGH LOW
• Insulin resistance • Hypoglycemia- reactive
• Early stage hyperglycemia/Diabetes • Hypoglycemia- Liver glycogen problem
• Metabolic Syndrome • Hyperinsulinism
Glucose • Thiamine Need • Adrenal hypofunction
• Cortisol resistance
• Fatty liver
• Liver congestion
• Diabetes mellitus • Hypoglycemia
Hemoglobin A1C
• Insulin resistance
• Metabolic Syndrome • Liver/biliary dysfunction
• Fatty liver • Thyroid hyperfunction
• Liver congestion • Autoimmune processes
• Insulin resistance • Adrenal hyperfunction
• Cardiovascular disease
• Atherosclerosis
• Poor metabolism and utilization of fats
Triglycerides
• Early stage hyperglycemia/Diabetes
• Hyperlipidemia/ Hyperlipoproteinemia
• Primary hypothyroidism
• Adrenal cortical dysfunction
• Secondary hypothyroidism- anterior pituitary
dysfunction
• Alcoholism
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BIOMARKER HIGH LOW
• Primary hypothyroidism • Oxidative stress
• Adrenal cortical dysfunction • Heavy metal body burden
• Cardiovascular disease • Liver/biliary dysfunction
• Atherosclerosis • Diet- malnutrition
• Biliary stasis • Thyroid hyperfunction
• Insulin resistance • Autoimmune processes
Cholesterol
• Poor metabolism and utilization of fats • Adrenal hyperfunction
• Fatty liver
• Early stage hyperglycemia/Diabetes
• Metabolic Syndrome
• Hyperlipoproteinemia
• Multiple sclerosis
• Diet- high in refined carbohydrates
LDL • Atherosclerosis
• Fatty liver/Hyperlipidemia
• Oxidative stress
• Autoimmune processes • Hyperlipidemia/Fatty Liver
• Atherosclerosis
HDL • Oxidative stress
• Heavy metals
• Hyperthyroidism
• Lack of exercise/sedentary lifestyle
• Renal disease • Diet- low protein
• Renal insufficiency • Malabsorption
• Dehydration • Pancreatic insufficiency
• Hypochlorhydria • Liver dysfunction
BUN • Diet- excessive protein intake
• Adrenal hyperfunction
• Dysbiosis
• Edema
• Anterior pituitary dysfunction
BIOMARKER HIGH LOW
• BPH • Muscle atrophy
• Urinary tract congestion • Protein insufficiency or impaired digestion
Creatinine • Renal disease
• Renal insufficiency
• Uterine hypertrophy
Bun/Creatinine • Renal disease • Diet- low protein
ratio • Posterior pituitary dysfunction
• Gout • Molybdenum deficiency
• Atherosclerosis/Oxidative stress • Anemia- B12/folate deficiency
• Arthralgias • Copper deficiency
Uric Acid
• Renal insufficiency/Renal disease
• Circulatory disorders
• Leaky gut syndrome
• Adrenal hypofunction • Adrenal hyperfunction
• Dehydration • Drug diuretics
Potassium
• Tissue destruction • Benign essential hypertension
• Metabolic acidosis
• Adrenal hyperfunction • Adrenal hypofunction
• Cushing’s disease • Addison’s disease
Sodium
• Dehydration • Edema
• Drug diuretics
• Metabolic acidosis • Hypochlorhydria
Chloride • Adrenal hyperfunction • Metabolic alkalosis
• Adrenal hypofunction
• Metabolic alkalosis • Metabolic acidosis
• Adrenal hyperfunction • Thiamine need
CO2
• Hypochlorhydria • Respiratory alkalosis
• Respiratory acidosis
• Thiamine need
Anion Gap
• Metabolic acidosis
• Dehydration • Hypochlorhydria
Total Protein • Digestive dysfunction and/or inflammation
• Liver dysfunction
BIOMARKER HIGH LOW
• Dehydration • Hypochlorhydria
Albumin
• Vitamin C need
• Hypochlorhydria • Digestive dysfunction and/or inflammation
• Liver cell damage • Immune insufficiency
Globulin
• Heavy metal toxicity
Albumin/ • Liver dysfunction
Globulin ratio • Immune activation
• Parathyroid hyperfunction • Parathyroid hypofunction
Calcium
• Thyroid hypofunction • Calcium need
• Impaired membrane health • Hypochlorhydria
• Parathyroid hypofunction • Parathyroid hyperfunction
• Bone growth and/or repair • Hypochlorhydria
Phosphorous
• Diet- excessive phosphorous consumption • Hyperinsulinism
• Renal insufficiency • Diet- high in refined carbohydrates
• Renal dysfunction • Epilepsy
Magnesium
• Thyroid hypofunction • Muscle spasm
• Biliary obstruction • Zinc deficiency
• Liver cell damage
• Bone: loss/increased turnover or bone growth
Alkaline
and/or repair
phosphatase
• Leaky gut syndrome
• Herpes zoster
• Metastatic carcinoma of the bone
• Liver/biliary dysfunction • Reactive hypoglycemia
• Cardiovascular disease
• Anemia- B12/folate deficiency, hemolytic
LDH
• Non-specific tissue inflammation
• Tissue destruction
• Viral infection
BIOMARKER HIGH LOW
• Dysfunction located outside of the liver and Biliary • B6 deficiency
tree • Alcoholism
• Developing Congestive Heart Failure
• Acute MI
• Cardiovascular dysfunction: Coronary artery
SGOT/AST
insufficiency
• Excess muscle breakdown or turnover
• Infectious mononucleosis, EBV, CMV
• Dysfunction located in the liver • B6 deficiency
• Fatty liver • Fatty liver (early development)
• Liver dysfunction • Liver congestion
SGPT/ALT • Biliary tract obstruction • Alcoholism
• Excessive muscle breakdown or turnover
• Cirrhosis of the liver
• Dysfunction located outside the liver and inside the • B6 deficiency
biliary tree • Magnesium need
• Biliary obstruction
• Biliary stasis/insufficiency
GGTP
• Alcoholism
• Acute/chronic Pancreatitis
• Pancreatic insufficiency
• Biliary stasis • Spleen insufficiency
• Thymus dysfunction
Total Bilirubin • Biliary tract obstruction or calculi
• RBC hemolysis
• Gilbert’s syndrome
BIOMARKER HIGH LOW
Direct Bilirubin • Biliary tract obstruction
• Biliary calculi/obstruction (usually extra hepatic)
• RBC hemolysis
Indirect Bilirubin
• Gilbert’s syndrome
• Liver dysfunction • Anemia- iron deficiency
• Hemochromatosis/hemosiderosis/iron overload • Hypochlorhydria
Serum Iron • Iron conversion problem • Internal/microscopic bleeding
• Viral infection
• Excess iron consumption
• Hemochromatosis/hemosiderosis/iron overload • Anemia- iron deficiency
Ferritin • Excess iron consumption
• Inflammation/liver dysfunction/oxidative stress
• Anemia- iron deficiency • Hemochromatosis/hemosiderosis/iron overload
TIBC • Internal bleeding • Microscopic bleeding
• Diet- protein malnutrition
% Transferrin • Hemochromatosis/hemosiderosis/iron overload • Anemia- iron deficiency
Saturation
• Primary hypothyroidism • Hyperthyroidism
• Secondary hypothyroidism- anterior pituitary
TSH dysfunction
• Tertiary hypothyroidism- hypothalamic dysfunction
• Heavy metal body burden
• Hyperthyroidism • Primary hypothyroidism
Total & FreeT-3
• Iodine deficiency • Selenium deficiency
Total & FreeT-4
• Thyroid hormone replacement • Iodine deficiency
• Thyroid hormone replacement • Secondary hypothyroidism- anterior pituitary
T-3 Uptake dysfunction
• Selenium deficiency
• Iodine deficiency
ESR • Non-specific tissue inflammation or destruction
COMPLETE BLOOD COUNT
BIOMARKER HIGH/LOW CONDITION

• Childhood diseases (Measles, Mumps, Rubella, • Chronic viral infections
Chicken pox etc.) • Chronic bacterial infections
White Blood Cell • Acute bacterial infection • Leukocytic auto-digestion
Count • Acute viral infection • Systemic Lupus Erythematosis (SLE)
• Stress • Decreased production from bone marrow
• Diet- High in refined carbohydrates • Diet- raw food diet
• Respiratory distress: Asthma or emphysema • Anemia- Iron deficiency
• Polycythemia (relative or absolute) • Anemia- B12/folate deficiency
Red Blood Cell
• Dehydration • Anemia- Copper deficiency
Count
• Internal bleeding
• Vitamin C need
• Respiratory distress: Asthma or emphysema • Anemia- iron deficiency
• Polycythemia (relative or primary) • Anemia- B12/folate deficiency
• Dehydration • Anemia- B6 deficiency anemia
Hemoglobin • Anemia- Copper deficiency
• Digestive inflammation
• Vitamin C need
• Respiratory distress: Asthma or emphysema • Anemia
• Polycythemia (relative or primary) • Anemia- Iron deficiency
• Spleen hyperfunction • Anemia- B12/folate deficiency
• Dehydration • Anemia- B6 deficiency
Hematocrit
• Anemia- Copper deficiency
• Digestive inflammation
• Thymus hypofunction
• Vitamin C need
• Anemia- B12/folate deficiency • Anemia- Iron deficiency
MCV • Vitamin C need • Anemia- B6 deficiency
BIOMARKER HIGH LOW
• Hypochlorhydria • Anemia- B6 deficiency
MCH • Internal bleeding
• Vitamin C need
• Hypochlorhydria • Anemia- B6 deficiency
MCHC
• Vitamin C need
• Anemia- Iron deficiency • Childhood diseases (Measles, Mumps, Rubella,
• Anemia- B12/folate deficiency Chicken pox)
RDW
• Pernicious anemia • Acute or chronic bacterial infection
• Inflammation
• Childhood disease (Measles, Mumps, Rubella, • Blood diseases (aplastic anemia, pernicious
Chicken Pox) anemia etc.)
Neutrophils
• Acute or chronic bacterial infection • Chronic viral infection
• Inflammation
• Recovery phase of infection
Monocytes
• Intestinal parasites
• Benign Prostatic Hypertrophy (BPH)
• Childhood diseases • Chronic viral or bacterial infections
• Acute and chronic viral infection • Free radical activity
Lymphocytes • Infectious mononucleosis • Active bacterial infection
• Inflammation • Suppressed bone marrow function
• Systemic toxicity
• Intestinal parasites • Increased adrenal steroid production
Eosinophils • Food and environmental allergies/sensitivities
• Asthma
• Tissue inflammation
Basophils
• Intestinal parasites
• Atherosclerosis • Idiopathic thrombocytopenia
Platelet count • Heavy metal body burden
• Free radical pathology

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FUNCTIONAL BLOOD CHEMISTRY ANALYSIS

Biomarkers and Their Conditions

BIOMARKER HIGH/LOW CONDITION

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