INTERNATIONAL ISLAMIC UNIVERSITY MALAYSIA

COURSE OUTLINE
Kulliyyah Engineering
Department Biotechnology Engineering
Programme B. Eng (Biochemical-Biotechnology)
Course Title Biochemical Kinetics
Course Code BTE 2520
Status Core
Level 2
Credit Hours 3
Contact Hours 3
Pre-requisites MTH 2212
(if any)
Co-requisites Nil
(if any)
Instructor(s) Assoc. Prof. Dr. Ibrahim Ali Noorbatcha
Semester Offered All Semesters
Course Synopsis Thermodynamics of biochemical systems, biochemical and biological
dynamics, kinetics of biochemical systems, biochemical spectroscopy
and structure determination, statistical thermodynamics and transport
properties, electrochemistry in the biological context, membrane
biophysics, and bioinstrumentation analysis.
Course The objectives of this course are:
Objectives 1. To introduce and develop the principles of physical chemistry for
applications into biological processes.
2. To provide an understanding in the area of fundamental biological
processes which are applicable to engineering system.
3. To correlate practical applications of physical chemistry and
engineering principles to biological processes.
Learning Upon completion of this course, students should be able to:
Outcomes 1. Calculate the energy that is required for or release from one
biological reaction using the knowledge of enthalpy, entropy and
Gibbs free energy.
2. Determine the property values of macromolecules such as binding
abilities, sedimentation coefficient, viscosity, diffusion etc.
3. Calculate and evaluate the rate of chemical reaction, especially for
biological reactions such as enzyme reaction etc (for engineering
design purpose).
4. Outline and describe the molecular structures and interactions, the
molecular distributions and statistical thermodynamics.
5. Evaluate the theoretical equations used behind advanced
bioinstrumentation equipments for calculating the specific data.
Instructional Lectures and tutorials
Strategies
Course LO Method %
Assessment 1,2,3, Mid-term Test 30
1,4,5 Quizzes 20
All Assignments 10
2,3,4,5 Final Examination 40
Total 100

Course Outlines / Week Topics Reading

Contents Assignment
1 Introduction to biophysical chemistry and Chapter 1, 2
first law of thermodynamics in relation to
chemical reactions: Heat effect, temperature
dependence, energy change for a reaction,
standard enthalpies of formation, and
molecular interpretations of energy and
enthalpy
2,3 Free energy and chemical equilibria: Gibbs Chapter 4
free energy and the chemical potential,
reactions of gases, non ideal systems,
equilibrium constant and standard Gibbs free
energies of reactants and products, galvanic
cells, biochemical applications of
thermodynamics, and redox reactions.

4,5 Free energy and physical equilibria: Phase Chapter 5

equilibria, membranes, active and passive
transport, colligative properties, and
molecular weight determination by using
free energy and physical equilibria.
6,7 Molecular motion and transport properties: Chapter 6
Sedimentation, determination of molecular
weights using molecular motion and
transport properties, measurement of
viscosity, electrophoresis, and size and shape
of macromolecules.
 8,9 Rate of chemical reactions: Kinetics, Chapter 7
reaction mechanisms and rate laws,
temperature dependence, transition state
theory, electron transfer reactions (Marcus
theory), ionic reactions and salt effects,
isotopes and stereochemical properties, very
fast reactions.
10 Enzyme kinetics: Michaelis-Menten Chapter 8
kinetics, competition and inhibition.
11,12 Molecular structures and interactions: Chapter 10
Spectroscopy, electromagnetic spectrum,
colour and refractive index, adsorption and
emission of radiation, proteins and nucleic
acids, fluorescence, optical rotatory
dispersion and circular dichroism, vibrational
spectra, infrared absorption, and Raman
scattering, and nuclear magnetic resonance
and its interactions.

13 Molecular distributions and statistical Chapter 11

thermodynamics: Binding of small
molecules by a polymer, random walk, helix-
coil transitions, statistical thermodynamics,
Boltzmann distribution.
14 Discussing the actual applications of the Handouts
selected theories and principles covered
above.
References Required:

Tinoco, I, Sauer, K, Wang, J. C. & Puglisi, J.D. (2002), Physical

Chemistry: Principles and Applications in Biological Sciences,
Prentice Hall, Inc.

Recommended:

Devoe, H. (2001), Thermodynamics & Chemistry, Prentice Hall,

Inc.
Hammes, G. G. (2000), Thermodynamics and Kinetics for the
Biological Sciences, John Wiley & Sons, Ltd.
Raff, L. M. (2001), Principles of Physical Chemistry, Prentice Hall,
Inc.
Sheehan, D. (2000), Physical Biochemistry: Principles &
Applications, John Wiley & Sons, Ltd.
Woodbury, G. (1997), Physical Chemistry, John Wiley & Sons, Ltd.
Proposed Start Semester III, 2005-2006
Date (Semester)
Batch of Students 2005 intake and onwards
to be Affected

Prepared by: Checked by: Approved by:

__________________ __________________ ______________

(Dr. Faridah Yusof ) (Prof. Suleyman A. Muyibi) (Prof. Ahmad F. Ismail)
 COURSE ASSESSMENT MATRIX: BTE2520
Course Code and Name
BTE2520 Biochemical Kinetics Biochemical - Biotechnology Engineering Programme Learning Outcomes

Outcome 1

Outcome 2

Outcome 3

Outcome 4

Outcome 5

Outcome 6

Outcome 7

Outcome 8

Outcome 9

Outcome 10

Outcome 11

Outcome 12

Outcome 13
NO.

Course Learning outcome

Calculate the energy that is required for or release from one biological reaction 3 2 2 3 2
1 using the knowledge of enthalpy, entropy and Gibbs free energy.
.

Determine the property values of macromolecules such as binding abilities, 3 3 2 2 3

2 sedimentation coefficient, viscosity, diffusion etc.
.

Calculate and evaluate the rate of chemical reaction, especially for biological 3 2 3 2 2
3 reactions such as enzyme reaction etc (for engineering design purpose).
.

Outline and describe the molecular structures and interactions, the molecular 3 2 2 3 2
4 distributions and statistical thermodynamics.
.

Evaluate the theoretical equation used behind the very advance bioinstrumentation 2 2 2 2
5 equipments for calculating the specific data. 3
.

Index of Biotechnology Engineering Programme Learning Outcomes

1. The ability to acquire and apply knowledge of Mathematics, science and engineering fundamentals.
2. To have acquired a broad based education necessary to understand the impact of engineering solutions in a global and societal context.
3. The ability to have in depth understanding and technical competency in Biochemical - Biotechnology Engineering.
4. The ability to undertake problem identification, formulation and solution.
5. The ability to design a system, component or process for operational performance.
6. The ability to design and conduct experiments as well as to analyze and interpret data.
7. The ability to understand the principles of sustainable design and development.
8. The ability to effectively communicate orally, in writing and using multimedia tools.
9. The ability to function effectively as an individual and in group with the capacity to be a leader or manager as well as an effective team leader member.
10. The ability to recognize the need for life long learning and posses the ability to pursue independent learning for professional development.
11. The ability to understand the social, cultural, global and environmental responsibilities of a professional engineer and the need foe sustainable development.
12. The ability to understand and commit to professional and ethical responsibilities.
13. The ability to understand the expectations of an engineer who practices in an industrial or governmental organization.