1.

In page 1, in introduction paragraf 1 line 3 “migrain particularly migraine with aura

has been consistenly associated with incresed stroke risk”, please more explain the
mechanism migrain can increased stroke risk
2. In page 6 left column paragraf 1 line 4 “as both condition are associated with
family history genetic marker play a role ...” please explain what genetic marker
play arole in migraine
3. In slide 14, disebutkan tentang prophylactic medication, please more explain about
prophylactic medication and when the time we can start to give prophylactic
medication
4. In page 6 left column paragraf 1 line 21 “ repetitive or chronic pain can also alter
blood pressure and lead to hypertension. Please more explain about the
mechanism chronic pain can lead hypertension
5. Based on the title in this journal “ migrain and the risk of incident hypertension
among women”. Is there any relationship between sex difference in migrain