PMID- 31442679

OWN - NLM
STAT- Publisher
LR - 20190829
IS - 1096-0023 (Electronic)
IS - 1043-4666 (Linking)
VI - 125
DP - 2019 Aug 20
TI - Evidence for interactions between inflammatory markers and renin-angiotensin
system molecules in the occurrence of albuminuria in children with sickle
cell
anemia.
PG - 154800
LID - S1043-4666(19)30229-7 [pii]
LID - 10.1016/j.cyto.2019.154800 [doi]
AB - Sickle cell anemia (SCA) is an important cause of chronic kidney disease, but
its
pathophysiology is not completely understood. The aim of this study was to
compare inflammatory biomarkers in urine samples of SCA children with and
without
albuminuria, and to explore correlations with renin-angiotensin system (RAS)
molecules. A cross-sectional study of 213 children selected from the Minas
Gerais
state cohort were assigned to two groups: Group 1-89 children with SCA who
had
albuminuria; Group 2-124 children with SCA and normal albuminuria matched by
age
and sex with group 1. A subset of 89 children was prospectively followed for
a
median time of 1.1year. Inflammatory biomarkers (chemokines and cytokines) in
urine were measured using cytometric beads array, and RAS molecules were
measured
by ELISA. Children with albuminuria had significantly higher urinary levels
of
IP-10/CXCL10, MCP-1/CCL2, MIG/CXCL9, IL-8/CXCL8, IL-12p70, TNF, IL-10, and
IL-6
than patients with normal albuminuria. In the correlation analysis,
albumin/creatinine ratio was significantly and positively correlated with
IP-10/CXCL10, MCP-1/CCL2, MIG/CXCL9, IL-8/CXCL8, TNF, IL-10, and IL-6.
Significant correlations were found between inflammatory and RAS molecules.
In
the prospective analysis, cumulative risk of persistent albuminuria was
higher
for children with urinary levels of IP-10/CXCL10 or IL-6 above the 50th
percentile. Our data showed that inflammatory markers and RAS molecules might
contribute to the occurrence of albuminuria in children with SCA, suggesting
that
both pathways interact in sickle cell nephropathy.
CI - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Belisario, Andre Rolim
AU - Belisario AR
AD - Centro de Tecidos Biologicos de Minas Gerais, Fundacao Hemominas, Lagoa
Santa,
Minas Gerais 33400-000, Brazil; Laboratorio Interdisciplinar de Investigacao
Medica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG),
Belo
Horizonte, Minas Gerais 30130-100, Brazil; Faculdade de Medicina/Nucleo de
Acoes
 e Pesquisa em Apoio Diagnostico (NUPAD), UFMG, Belo Horizonte, Minas Gerais
30130-100, Brazil. Electronic address: andrebelisario@yahoo.com.br.
FAU - Vieira, Erica Leandro Marciano
AU - Vieira ELM
AD - Laboratorio Interdisciplinar de Investigacao Medica, Faculdade de Medicina,
Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais
30130-100, Brazil.
FAU - de Almeida, Jessica Alves
AU - de Almeida JA
AD - Laboratorio Interdisciplinar de Investigacao Medica, Faculdade de Medicina,
Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais
30130-100, Brazil.
FAU - Mendes, Fabiola Gomes
AU - Mendes FG
AD - Laboratorio Interdisciplinar de Investigacao Medica, Faculdade de Medicina,
Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais
30130-100, Brazil.
FAU - Miranda, Aline Silva
AU - Miranda AS
AD - Laboratorio Interdisciplinar de Investigacao Medica, Faculdade de Medicina,
Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais
30130-100, Brazil.
FAU - Rezende, Paulo Val
AU - Rezende PV
AD - Faculdade de Medicina/Nucleo de Acoes e Pesquisa em Apoio Diagnostico
(NUPAD),
UFMG, Belo Horizonte, Minas Gerais 30130-100, Brazil.
FAU - Viana, Marcos Borato
AU - Viana MB
AD - Faculdade de Medicina/Nucleo de Acoes e Pesquisa em Apoio Diagnostico
(NUPAD),
UFMG, Belo Horizonte, Minas Gerais 30130-100, Brazil.
FAU - Simoes E Silva, Ana Cristina
AU - Simoes E Silva AC
AD - Laboratorio Interdisciplinar de Investigacao Medica, Faculdade de Medicina,
Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais
30130-100, Brazil. Electronic address: acssilva@hotmail.com.
LA - eng
PT - Journal Article
DEP - 20190820
PL - England
TA - Cytokine
JT - Cytokine
JID - 9005353
SB - IM
OTO - NOTNLM
OT - Biomarker
OT - Inflammation
OT - Nephropathy
OT - Renin-angiotensin system
OT - Sickle cell anemia
EDAT- 2019/08/24 06:00
MHDA- 2019/08/24 06:00
CRDT- 2019/08/24 06:00
PHST- 2018/11/23 00:00 [received]
PHST- 2019/04/29 00:00 [revised]
PHST- 2019/08/05 00:00 [accepted]
PHST- 2019/08/24 06:00 [pubmed]
PHST- 2019/08/24 06:00 [medline]
PHST- 2019/08/24 06:00 [entrez]
AID - S1043-4666(19)30229-7 [pii]
AID - 10.1016/j.cyto.2019.154800 [doi]
PST - aheadofprint
SO - Cytokine. 2019 Aug 20;125:154800. doi: 10.1016/j.cyto.2019.154800.