Anti-inflammatory: IBUPROFEN DRUGS

Drug Name Dosage Indications Mechanism of Action Contraindications
100mg/5ml 5ml o Mild to moderate pain Unknown. Produces anti- o Contraindicated in
Name: Ibuprofen PRN, Oral o Fever inflammatory, analgesic, patients hypersensitive
o Juvenile arthritis and anti-pyretic effects, to drug and in those with
Brand Name: possibly by inhibiting angio-edema, syndrome
Children’s Motrin prostaglandin synthesis. of nasal polyps, or
bronchospastic reaction
Classification: to aspirin or other
Non-steroidal anti- NSAIDs.
inflammatory drugs o Contraindicated in
pregnant women.
o Use cautiously in
patients GI disorders,
history of peptic ulcer
disease, hepatic or renal
disease, cardiac
decompensation,
hypertension, preexisting
asthma, or known
intrinsic coagulation
defects
Adverse Reaction
CNS: headache, dizziness,
nervousness, aseptic
minigitis
CV: peripheral edema, fluid
retention, edema
EENT: tinnitus
GI: epigastric distress,
nausea, occult blood loss,
peptic ulceration, diarrhea,
constipation, abdominal
pain, bloating, GI fullness,
dyspepsia, flatulence, heart
burn, decreased appetite
GU: acute renal failure,
azotemia, cystitis, hematuria
Hematologic: prolonged
bleeding time, anemia,
neutroenia, pancytopenia,
thrombocytopenia, aplastic
anemia, leucopenia,
agranulocytosis
Metabolic: hypoglycemia,
hyperkalemia
Respiratory:
bronchospasm
Nursing Responsibilities
o Established rapport
o Vital sign taken and
recorded
o IVF checked
o Check renal and hepatic
function periodically in
patients on long-term
therapy.
o It may take 1 or 2
weeks before full anti-
inflammatory effects
occur
o Serious GI toxicity,
including peptic ulcers
and bleeding, in patient
taking NSAIDs, despite
lack of symptoms
o If patient consumes
three or more alcoholic
drinks per day, use of
ibuprofen may lead to
stomach bleeding
o Alert: don’t confuse
Trendar with Trandate