1. Some of the functions of kidneys include water and electrolyte balance, plasma volume and osmolarity regulation, and hormone secretion. 2. Angiotensin and erythropoietin are hormones secreted by the kidneys. 3. Filtration, reabsorption, and secretion are three main processes occurred in nephron. 4. The ascending and descending limbs of the Loop of Henle are responsible for creating a counter-current multiplier system which concentrates urine. 5. The glomerulus and Bowman's capsule are responsible for collecting and producing initial filtrate from the blood. 6. The filtrate becomes less concentrated as it moves up the loop of Henle because the ascending limb is permeable to water. 7. The juxtaglomerular cells sense sodium content in urine of the proximal tubule. 8. The juxtaglomerular cells release renin in response to a low level of sodium in the filtrate. 9. Angiotensinogen is converted to angiotensin I by angiotensin converting enzyme (ACE) in the lung. 10. The collecting duct is usually relatively impermeable to water. Action of antidiuretic hormone causes the insertion of aquaporins in the collecting duct, allowing water to exit the filtrate into the extracellular space. 11. The bottom of the descending loop of Henle is the location where the filtrate is at the most concentrated state when ADH is not present. 12. Aldosterone acts in the collecting tubule to increase the rate of sodium reabsorption by increasing the number of sodium-potassium pump proteins implanted in the cells of this region. 13. To maintain electrical neutrality, when sodium is reabsorbed, potassium is secreted. 14. In a diabetes patient, the elevated glucose in the filtrate increases urine osmolarity and causes the filtrate to retain water. The result is an increase in urine volume, resulting in more frequent urination. 15. The distal tubule of the nephron is responsible for reabsorbing sodium and calcium and secreting potassium, hydrogen, and bicarbonate. 16. Increase in plasma sodium and fall in blood pressure will increase secretion of aldosterone through renin-angiotensin-aldosterone system. 17. Glucose, amino acids, and urea are secreted into the filtrate by proximal tubule. 18. Voluntary signals from cerebral cortex can override the micturition reflex or allow it to take place by contraction or relaxation of internal sphincter. 19. Under normal conditions, 99% of calcium filtered in the glomeruli is reabsorbed in the nephrons. 20. Most of the hydrogen ions in the body come from acidic substances in the foods we ingest.