Sie sind auf Seite 1von 9

The n e w e ng l a n d j o u r na l of m e dic i n e

Case Records of the Massachusetts General Hospital

Founded by Richard C. Cabot


Eric S. Rosenberg, M.D., Editor
Virginia M. Pierce, M.D., David M. Dudzinski, M.D., Meridale V. Baggett, M.D.,
Dennis C. Sgroi, M.D., Jo‑Anne O. Shepard, M.D., Associate Editors
Kathy M. Tran, M.D., Case Records Editorial Fellow
Emily K. McDonald, Sally H. Ebeling, Production Editors

Case 26-2019: A 27-Year-Old Woman


with Opioid Use Disorder and Suicidal Ideation
Mladen Nisavic, M.D., Efren J. Flores, M.D., Marilyn Heng, M.D., M.P.H.,
Nicholas J. Kontos, M.D., and Nadia Quijije, M.D.​​

Pr e sen tat ion of C a se

Dr. Andrew Cruz (Psychiatry): A 27-year-old woman was evaluated at this hospital From the Departments of Psychiatry
because of a suicide attempt. (M.N., N.J.K., N.Q.), Radiology (E.J.F.),
and Orthopedics (M.H.), Massachusetts
Approximately 3 months before admission, the patient became homeless and General Hospital, and the Departments
was staying intermittently with friends. Two months before admission, she began of Psychiatry (M.N., N.J.K., N.Q.), Radiol‑
to ingest clonazepam daily, and 3 weeks before admission, she began to use intra- ogy (E.J.F.), and Orthopedics (M.H.),
Harvard Medical School — both in Bos‑
nasal heroin daily. She had depression and anxiety, and 2 days before admission, ton.
she expressed that she felt “tired of living this life” and wanted “to end it all.”
N Engl J Med 2019;381:763-71.
On the evening of presentation, the patient reportedly smashed her cell phone DOI: 10.1056/NEJMcpc1904043
on the ground and ate the glass shards as a suicide attempt. Nausea and diffuse Copyright © 2019 Massachusetts Medical Society.
abdominal discomfort developed, and she reportedly had an episode vomiting, with
the vomit containing 2 teaspoons (10 ml) of blood. Three hours after the ingestion,
she presented to the emergency department of this hospital with throat, chest, and
abdominal pain. She reported that she had “regret” about the ingestion and
wanted “help” with her substance use and suicidality.
The patient reported past sexual trauma but did not provide details; she did not
report any previous suicide attempts, homicidal ideation, or hallucinations. A limit­
ed review of systems was notable for anorexia, diaphoresis, diarrhea, impaired
sleep, fatigue, mood lability, nightmares, and flashbacks. Her psychiatric history
included polysubstance use disorder (with the use of intravenous heroin, fentanyl,
benzodiazepines, and cocaine), cutting behavior during adolescence, and anxiety
and depression. She had never undergone psychiatric treatment or hospitalization.
Her medical history included hepatitis C virus infection, obesity, genital herpes
simplex virus infection, and a low-grade squamous intraepithelial lesion of the
cervix; in addition, a motor vehicle collision had led to open reduction and internal
fixation involving the left arm. She took no medications and had no known ad-
verse reactions to medications. She worked in a local store and had a small child.
She had smoked one and a half packs of cigarettes daily for the past 10 years and

n engl j med 381;8 nejm.org  August 22, 2019 763


The New England Journal of Medicine
Downloaded from nejm.org by David Pakpahan on September 1, 2019. For personal use only. No other uses without permission.
Copyright © 2019 Massachusetts Medical Society. All rights reserved.
The n e w e ng l a n d j o u r na l of m e dic i n e

was a current smoker. She drank 1 pint of vodka protrude posteriorly and medially without ecchy-
daily and reported no history of withdrawals or mosis. The patient was not able to move the arm
blackouts. Multiple relatives, including both of at the elbow, although range of motion was intact
her parents, had a history of substance use dis- at the shoulder and wrist.
order. Dr. Flores: A lateral image of the right elbow
On examination, the temperature was 36.8°C, (Fig. 2A) showed posterior dislocation of the el-
the pulse 70 beats per minute, and the oxygen bow with impaction of the olecranon process of
saturation 96% while the patient was breathing the ulna into the distal humerus outside the
ambient air. She appeared disheveled, tearful, olecranon fossa. An anteroposterior image of
and anxious. Abdominal examination revealed the right elbow (Fig. 2B) confirmed dislocation
mild tenderness on the right side on palpation. of the elbow with malalignment of the ulnotroch-
On examination by a psychiatrist, she had limited lear and radiocapitellar joints.
eye contact and mumbling speech, along with Dr. Cruz: After the administration of aceta­
poor concentration, depressed mood with a con- minophen, ibuprofen, oxycodone, and intrave-
gruent affect, and poor insight and judgment. nous morphine, the elbow was manually reduced
The complete blood count and levels of electro- and a splint was applied. Additional radiograph-
lytes, urea nitrogen, creatinine, lactate, bilirubin, ic images were obtained.
alkaline phosphatase, and albumin were normal; Dr. Flores: Lateral and anteroposterior images
the aspartate aminotransferase level was 162 U of the right elbow obtained after closed reduc-
per liter (reference range, 9 to 32), and the ala- tion and splinting (Fig. 2C and 2D) showed nor-
nine aminotransferase level was 52 U per liter mal alignment of the ulnotrochlear and radio-
(reference range, 7 to 33). Ethanol was not de- capitellar joints.
tected in the blood, and human chorionic gonado- Dr. Cruz: During the next 18 hours, the patient
tropin was not detected in the urine. A urine remained under observation, with a plan for
toxicology screen was positive for opioids and transfer to an inpatient psychiatric hospital for
cocaine metabolites. The findings on an electro- ongoing care. One hour before transfer, the pa-
cardiogram were normal and unchanged from a tient went to the bathroom without her observer
tracing obtained 10 years earlier. and then reported that she could not move her
Dr. Efren J. Flores: The results of radiography of right arm.
the neck, chest, and abdomen were normal, Dr. Flores: A lateral image of the right elbow
without a visible radiopaque foreign body. Com- showed that the splint was in place and showed
puted tomography (CT) of the abdomen and pel- posterior dislocation of the elbow with impaction
vis, performed after the administration of intra- of the olecranon process of the ulna into the
venous contrast material (Fig. 1), revealed distal humerus outside the olecranon fossa. An
gallbladder wall thickening and trace perihepatic anteroposterior image of the right elbow con-
fluid. These findings can be seen in patients with firmed dislocation of the elbow with predomi-
acute hepatitis. There was no evidence of pneumo- nant involvement of the radiocapitellar joint. There
peritoneum or of a radiopaque foreign body. was irregularity of the radial head and lateral
Dr. Cruz: Intravenous normal saline, morphine humeral epicondyle that was consistent with a
sulfate, and piperacillin–tazobactam were admin- nondisplaced fracture.
istered. The patient was evaluated by the surgery Dr. Cruz: Intravenous morphine was adminis-
and psychiatry services. Because of concern tered. The elbow was again reduced, and a cir-
about the patient’s risk of self-harm, an order cumferential fiberglass cast was placed.
that authorized temporary involuntary hospital- Dr. Flores: A lateral image of the right elbow
ization was implemented. obtained after the second closed reduction and
The next evening, the patient reported that casting showed normal alignment and the pres-
while she was trying to get out of a stretcher, she ence of a cast.
“heard a pop” in her right elbow, which was ac- Dr. Cruz: The next afternoon, after the plan for
companied by immediate pain without any numb- transfer to a psychiatric hospital was shared with
ness or tingling. On examination by an orthope- the patient, she was found in the bathroom with-
dic surgeon, the olecranon process appeared to out her observer, where she was banging her left

764 n engl j med 381;8 nejm.org  August 22, 2019

The New England Journal of Medicine


Downloaded from nejm.org by David Pakpahan on September 1, 2019. For personal use only. No other uses without permission.
Copyright © 2019 Massachusetts Medical Society. All rights reserved.
Case Records of the Massachuset ts Gener al Hospital

A Differ en t i a l Di agnosis

Dr. Mladen Nisavic: This 27-year-old woman with


active polysubstance use disorder (with the use of
alcohol, benzodiazepines, cocaine, and opioids)
presented to the hospital after a reported suicide
attempt by means of foreign-body ingestion.
During the initial safety evaluation and surgical
stabilization, a history of polysubstance use, anxi-
ety, depressed mood, and trauma was elicited; she
reported no previous suicide attempts.
The patient’s initial vital signs were normal,
and she had no physical findings consistent with
active alcohol withdrawal. The report of diarrhea,
B diaphoresis, and abdominal discomfort would
arouse concern about early opioid withdrawal,
given the recent use of opioids and reported his-
tory of opioid use disorder. Drug screening was
notable for the presence of opioids and cocaine.
Alcohol and benzodiazepines were not detected,
nor was the heroin-specific metabolite 6-mono-
acetylmorphine.
Initial plain radiography of the chest and
abdomen and abdominal CT did not reveal any
ingested foreign bodies. It is important to note
that small pieces of metal, glass, and plastic
(which are presumed components of most cell
Figure 1. CT Scan of the Abdomen and Pelvis. phones) may not be reliably detected on imaging
Coronal and axial images (Panels A and B, respectively) studies. However, in this case, the complete ab-
of the abdomen and pelvis, obtained after the adminis‑ sence of imaging findings raises the question of
tration of intravenous contrast material, show gallblad‑ whether the patient is being truthful about at-
der wall thickening (arrows) and trace perihepatic fluid tempting suicide.1 It is also important to note
(Panel A, arrowhead). These findings can be seen in
patients with acute hepatitis. There is no evidence of
that, despite the ultimate absence of trauma and
pneumoperitoneum or of a foreign body. of evidence of foreign-body ingestion, the pa-
tient reported clinically significant pain and in-
travenous opioids were administered.
arm against the wall. She reported pain, and oral My concern regarding this patient’s overall
oxycodone and intramuscular hydromorphone engagement and truthfulness with the team is
were administered. further confirmed on review of her subsequent
Dr. Flores: A lateral image of the left elbow stay in the surgery unit. Over the course of 3 days,
obtained hours after the second reduction and the patient had two episodes of seemingly spon-
casting of the right elbow (Fig. 2E) showed pos- taneous dislocation of the right elbow before she
terior dislocation of the left elbow and a frag- was observed actively attempting to dislocate her
ment from a displaced fracture of the trochlea. left elbow. Despite the presence of an observer,
There were two screws in the lateral humeral details regarding the way in which the first two
epicondyle from previous open reduction and injuries occurred are scarce; in both cases, the
internal fixation. patient reported afterward that the dislocation
Dr. Cruz: Intraarticular nerve block was per- was spontaneous and claimed to have no insight
formed. The left elbow was reduced, and a long- into the event. Despite prompt orthopedic treat-
arm circumferential fiberglass cast was placed. ment, she reported clinically significant pain
Additional management decisions were made. with each dislocation and intravenous opioids

n engl j med 381;8 nejm.org  August 22, 2019 765


The New England Journal of Medicine
Downloaded from nejm.org by David Pakpahan on September 1, 2019. For personal use only. No other uses without permission.
Copyright © 2019 Massachusetts Medical Society. All rights reserved.
The n e w e ng l a n d j o u r na l of m e dic i n e

A B

C D

766 n engl j med 381;8 nejm.org August 22, 2019

The New England Journal of Medicine


Downloaded from nejm.org by David Pakpahan on September 1, 2019. For personal use only. No other uses without permission.
Copyright © 2019 Massachusetts Medical Society. All rights reserved.
Case Records of the Massachuset ts Gener al Hospital

Figure 2 (facing page). Radiographs of the Elbows.


toward establishing the pertinent diagnosis and
A lateral image of the right elbow obtained after the
identifying any additional problems.
patient reported that she “heard a pop” (Panel A) shows In gaining an understanding of this patient’s
posterior dislocation of the elbow with impaction of the presentation, some of the major components of
olecranon process of the ulna into the distal humerus the history — such as depressed mood, anxiety,
outside the olecranon fossa. An anteroposterior image and post-traumatic stress disorder — are notable.
of the right elbow (Panel B) confirms dislocation of
the elbow with malalignment of the ulnotrochlear joint
Despite her initial endorsement of mood, anxiety,
(arrowhead) and radiocapitellar joint (arrow). A lateral and safety concerns, she quickly stopped report-
image of the right elbow obtained after closed reduc‑ ing these symptoms during her stay in the sur-
tion and splinting (Panel C) shows normal alignment. gery unit. In addition, there are few findings
An anteroposterior image of the right elbow (Panel D) that would allow us to ascribe the patient’s be-
confirms normal alignment of the ulnotrochlear and
radiocapitellar joints. A lateral image of the left elbow
havior to an episode associated with untreated
(Panel E) shows posterior dislocation of the elbow and major depressive disorder. An underlying thought
a fragment from a displaced fracture of the trochlea. disorder or acute mania may be considered, pri-
There are two screws in the lateral humeral epicondyle marily given the bizarre nature of her recurrent
from previous open reduction and internal fixation. injuries. However, neither of these diagnoses
appears to be consistent with the remainder of
the history. The patient did not have a history of
were administered. Furthermore, the second and clinically significant severe and persistent mental
third dislocations had a notable temporal correla- illness, and no cardinal symptoms of either acute
tion with the planned transfer to an inpatient mania or psychosis were described throughout
psychiatric facility, with the injuries occurring her hospitalization. No negative symptoms of a
mere hours before the transfer was meant to occur. major thought disorder were described, either.
In summary, a young woman with polysub- Personality vulnerability or frank personality
stance use disorder self-presented after a self- disorders could also be considered, especially
reported suicidal gesture, and ultimately, no given the patient’s history of trauma. However,
objective evidence of foreign-body ingestion was we do not have the necessary information to
discovered. During routine surgical observation support these diagnoses, and her brief hospital-
for clearance before planned transfer to an inpa- ization offers insufficient exposure to allow us
tient psychiatric facility, the patient appears to to make these diagnoses.
have engaged in repeated acts of self-harm, and Multiple substance use disorders were noted in
until she was discovered engaging in such an act, this case, and I strongly suspect that substance
she described each new injury as unintentional. use is playing a considerable role in this patient’s
With each incident, she reported clinically sig- presentation. Acute intoxication (e.g., with co-
nificant pain and intravenous opioids were ad- caine) may be associated with unusual behavior,
ministered. but repeated use while under strict observation
Which diagnosis or diagnoses may explain in the hospital would be unlikely. Withdrawal
this patient’s recurrent pattern of self-harm and from alcohol or benzodiazepines can be linked
limited engagement with the team? It is impor- with delirium, but the patient’s behavior appears
tant to construct a broad differential diagnosis to be deliberate, methodical, and devoid of acute
even if the diagnosis initially appears certain. confusion and of any other signs or symptoms
Maintaining a broad differential diagnosis can of acute withdrawal from one of these agents,
help us to adequately confirm the major problem such as tremor or changes in vital signs. She
and to potentially identify less active or obvious reported recent opioid use, and her initial ex-
contributors to the clinical situation. During amination was notable for some signs of early
psychiatric assessment, it is critical to consider opioid withdrawal. Furthermore, she requested
each major component of the psychiatric review intravenous opioids at the time of the initial pre-
of symptoms and the way in which each compo- sentation and with each episode of self-injurious
nent may apply to the case and help us to under- behavior. Could opioid use disorder be the unify-
stand the patient’s behavior and actions. Such an ing diagnosis in this case?
approach offers a thorough and methodical path In the presence of intentional and repetitive

n engl j med 381;8 nejm.org  August 22, 2019 767


The New England Journal of Medicine
Downloaded from nejm.org by David Pakpahan on September 1, 2019. For personal use only. No other uses without permission.
Copyright © 2019 Massachusetts Medical Society. All rights reserved.
The n e w e ng l a n d j o u r na l of m e dic i n e

self-harm, a diagnosis in the category of somatic address the patient’s goals than to distinguish
symptom and related disorders could also be between factitious disorder and malingering.
explored. A deception syndrome (factitious dis- There is minimal evidence-based guidance for
order or malingering) is a strong consideration, the identification of clinically significant decep-
given the multiple inconsistencies in the avail- tion, particularly that involving psychological
able information and ultimate evidence of de- symptoms. The method for making an action-
liberate self-infliction of injuries. To rule out an able diagnosis of malingering is unsettled, even
occult medical cause, I performed a literature in forensic situations, in which dedicated neuro-
search for spontaneous and recurrent elbow dis- psychological tests are used.7,8 It is not surpris-
locations. The review offered limited data but ing that underidentification of malingering in
provided reassurance that spontaneous elbow the clinical setting is common.9,10
dislocation is an uncommon finding outside This patient reported a specific suicide at-
specific populations (e.g., children and male tempt, with a motive and associated pain and
athletes), and when it occurs, it is often linked fear, and she later reported elbow pain and im-
with preexisting joint vulnerability.2-4 mobility. At face value, this patient’s history
The patient’s history offers minimal evidence warranted concern from clinicians who were
that her behavior reflects an unconscious need making decisions about safety precautions. How-
to maintain a sick role, a hallmark of factitious ever, because the patient did not have physical
disorder. Instead, there appears to be a strong findings (e.g., oropharyngeal lesions) or imag-
correlation between her behavior and opioid ad- ing findings that would support the reported
ministration, which would reflect secondary gain, ingestion and because she had disengaged from
a hallmark of malingering. I suspect that the subjects about which she had initially expressed
best explanation of this patient’s behavior lies at desperate concern, suspicions appropriately rose.
the intersection of substance use and deception Such suspicions might be inhibited by concerns
syndrome. about stigmatization, doctor–patient rapport, and
even liability.11 Allowing suspicion without cyni-
cism or premature closure is an early hurdle in
Dr . Ml a den Nis av ic’s Di agnosis
deception assessment.12
Severe opioid use disorder and malingering (de- Some experts advise and others discourage
ception syndrome). confrontation of patients who have possible de-
ception syndrome, and approaches to confronta-
tion are seldom defined. An approach that is
Ps ychi at r ic Di agnosis
incremental, honestly poses and compares con-
Dr. Nicholas J. Kontos: After multiple psychiatric flicting points of view, and attends to the ethical
interviews, the patient reported that she had lied implications of a potentially one-sided good-faith
about her suicide attempt and had intentionally relationship13 is consistent with a “feedback mod-
dislocated her elbows. She also reported that her el,” in which rapport and attention to reasons for
goal in both cases was to obtain opioids, con- deception are emphasized.14 In this case, con-
firming the diagnosis of malingering. frontation of the patient began with an unrecip-
The Diagnostic and Statistical Manual of Mental rocated attempt to engage and a statement of
Disorders, fifth edition,5 classifies malingering helpful intent. Then, inconsistencies in the avail-
among “other conditions that may be a focus of able information were addressed with curiosity
clinical attention.” Malingering is not a psychiat- and met with irritation from the patient. The
ric disorder. It can be distinguished from facti- next day, the patient explained her behavior but
tious disorder by the presence of behavior that is otherwise remained irritably disengaged. Con-
directed toward tangible gains, as opposed to tinued confrontation was eventually met with
behavior that is directed toward intangible sick- meaningful engagement, including participation
role gains. Sick-role gains include receiving care, in motivational interviewing.
being excused from duties, and being able to Most patients with deceptive behaviors do not
place blame on sickness.6 The line between tan- readily explain those behaviors. Yet, misrepre-
gible and intangible gains can be blurry; it is sented psychological symptoms are strongly sus-
sometimes more important to describe and try to pected in up to 20% of psychiatric emergency

768 n engl j med 381;8 nejm.org  August 22, 2019

The New England Journal of Medicine


Downloaded from nejm.org by David Pakpahan on September 1, 2019. For personal use only. No other uses without permission.
Copyright © 2019 Massachusetts Medical Society. All rights reserved.
Case Records of the Massachuset ts Gener al Hospital

department visits15 and reported anonymously by cal recommendations. In this situation, the gen-
8 to 10% of psychiatric inpatients.16-18 Nonethe- eral approach of the orthopedic surgeon would
less, it is important for physicians to remain be either to maintain prolonged casting or to do
skeptical of their own intuitions about and nothing while the issues behind the behavior
strong reactions against possible deception. Phy- leading to intentional dislocation are addressed.
sicians have no special aptitude for detecting
deception in unfamiliar patients.19 Medical rec­ Management of Deception Syndromes
ords may provide a longitudinal perspective that Dr. Kontos: Only case reports and experience guide
reveals consistencies across presentations or in- the clinical management of malingering. In prac-
consistencies within reports. A patient who is tice, management occurs in three domains: treat-
unfamiliar to an individual physician may be ment, shifting of the patient’s strategies, and
quite familiar at the institutional level. Close punishment. Treatment addresses the conse-
review of available records may be valuable when quences of self-harm; in this case, it involved
evaluating a patient with possible malingering. casting of the affected limbs. Treating an objec-
tive pathologic condition (e.g., an infection or
ingestion) must proceed independently of and
Discussion of M a nagemen t
in parallel with addressing its cause. Psychiatric
Orthopedic Management treatment for malingering focuses on possible
Dr. Marilyn Heng: Because the elbow joint has coexisting conditions (e.g., substance use or per-
bony stability with a deep ulnohumeral contour sonality disorder).
and capsular and ligamentous constraints, it is a The confrontation and feedback involved in
difficult joint to dislocate.20 Prompt restoration the detection of malingering can engage the
of articular alignment by means of closed reduc- patient in the work of shifting maladaptive life
tion is desired to reduce the risk of swelling, strategies in favor of adaptive ones. The goal is
damage to the articular cartilage, and neurovas- to “move the discussion from the traditional
cular compromise. Reduction of the dislocated reliance on medical or psychological causes to a
elbow usually results in pain relief for the pa- consideration of the reasons” behind malinger-
tient. The administration of narcotic pain medi- ing.14 Common reasons include addiction, legal
cation is not usually continued after reduction entanglements, and the need for food, shelter,
for simple elbow dislocation; at most, only a short and safety. In some cases, the health care system
course (1 to 2 days) is administered. Simple elbow is unable to meet these needs other than by di-
dislocation without associated fracture is usually recting the patient toward a different path. The
treated nonoperatively, with treatment followed application of clinical tools to purely social
by a period of immobilization. In this patient, the problems may do more harm than good.
results of clinical examination and the previous A patient’s inability or unwillingness to recip-
dislocation of the right elbow would lead to a rocate reasons-based engagement can necessitate
plan for a longer-than-usual period (2 to 3 weeks) interventions with the appearance of punish-
of immobilization. ment or actual punishment. Sometimes, the only
The patient’s active attempts to redislocate good outcome of malingering is the prevention of
her elbow resulted in breakage of her splint. iatrogenic harm and the nonparticipation of the
Conversion to a circumferential fiberglass cast clinician or institution in reinforcing maladap-
prevented her from intentionally dislocating the tive behaviors. A security-facilitated “therapeutic
right elbow but then provoked her to dislocate discharge”21,22 may be needed for recalcitrant
the left elbow. Closed reduction and long-arm patients. In extreme cases, criminal prosecution
casting of the left elbow was performed. Surgery for theft of service might be considered.11
for recurrent elbow dislocation consists of repair
of ligamentous structures, with or without exter- Management of Opioid Use Disorder
nal fixation. However, a cautious approach should Dr. Nadia Quijije: When treating a patient with
be taken for patients who intentionally, habitu- opioid use disorder and coexisting acute pain in
ally dislocate a joint for secondary gain. In such the inpatient setting, I keep three major compo-
patients, surgical treatment is associated with a nents in mind: opioid withdrawal, undertreated
high risk of failure due to nonadherence to medi- pain, and longitudinal treatment through medi-

n engl j med 381;8 nejm.org  August 22, 2019 769


The New England Journal of Medicine
Downloaded from nejm.org by David Pakpahan on September 1, 2019. For personal use only. No other uses without permission.
Copyright © 2019 Massachusetts Medical Society. All rights reserved.
The n e w e ng l a n d j o u r na l of m e dic i n e

cation-assisted strategies (suboxone or metha- acute pain and the longitudinal treatment of
done maintenance therapy). In this case, I was opioid use disorder.25 This patient was not inter-
concerned about the patient’s risk of opioid ested in receiving methadone; she was agreeable
withdrawal, given her consistent use of heroin. to the initiation of suboxone as medication-
When I met the patient, it had been 3 days since assisted treatment for opioid use disorder but
her last opioid use, so she was still within the not for the management of acute pain. It was
window for withdrawal symptoms but had been recommended that suboxone be initiated after
receiving short-acting opioids for pain along with immediate needs were resolved to allow for ad-
agents for the management of opioid withdrawal equate pain management and to avoid suboxone-
symptoms (dicyclomine for abdominal cramps induced opioid withdrawal.26 The inpatient set-
and acetaminophen for muscle aches). In the ting is a prime place to set up aftercare treatment
management of opioid withdrawal, it is impor- with intensive outpatient programs, methadone
tant to assess for both subjective symptoms maintenance clinics, suboxone prescribers, recov-
(anxiety, abdominal cramps, and muscle aches) ery coaches, or Narcotics Anonymous.27 We had
and objective symptoms (diaphoresis, dilated planned to transfer this patient to a dual-diag-
pupils, and piloerection). This patient reported nosis inpatient unit to obtain treatment for acute
and seemed most distressed about “sweats substance use disorder and to establish aftercare
and anxiety,” for which I recommended the addi- planning.
tion of clonidine, which can specifically relieve Dr. Cruz: The patient declined treatment for
these symptoms by means of norepinephrine substance use disorder and social-work assis-
dampening.23 tance with shelter. After discharge from the
During the treatment of this patient’s pain, hospital, she presented to the emergency depart-
she reported feeling comfortable with the pre- ment five times in the following week. On the
scribed oxycodone, and therefore, we did not final presentation, she asked that the arm casts
recommend changing the agent or adjusting the be removed, and she has not presented to the
dose. However, it is important to keep in mind emergency department in more than 6 months.
that patients with opioid use disorder are likely
to have a high tolerance for opioids and will Fina l Di agnosis
therefore probably need a high dose of opioids
for treatment, especially when they are undergo- Opioid use disorder and malingering.
ing surgical or medical procedures, as in this This case was presented at Psychiatry Grand Rounds.
case.24 This is also an opportunity to discuss Disclosure forms provided by the authors are available with
the full text of this article at NEJM.org.
medication-assisted treatments, such as suboxone We thank Dr. John Taylor for assistance with selection of this
and methadone, for both the management of case and organization of the conference.

References
1. Poynter BA, Hunter JJ, Coverdale JH, 7. Rogers R, Bender SD, eds. Clinical as- 12. Beach SR, Taylor JB, Kontos N. Teach-
Kempinsky CA. Hard to swallow: a sys- sessment of malingering and deception. ing psychiatric trainees to “think dirty”:
tematic review of deliberate foreign body 4th ed. New York:​Guilford Press, 2018. uncovering hidden motivations and de-
ingestion. Gen Hosp Psychiatry 2011;​33:​ 8. Young G. Malingering, feigning, and ception. Psychosomatics 2017;​58:​474-82.
518-24. response bias in psychiatric/psychological 13. Kontos N, Querques J, Freudenreich O.
2. O’Driscoll SW. Classification and eval- injury:​implications for practice and court. Fighting the good fight: responsibility
uation of recurrent instability of the elbow. New York:​Springer, 2014. and rationale in the confrontation of pa-
Clin Orthop Relat Res 2000;​370:​34-43. 9. Hamilton JC, Eger M, Razzak S, Feld- tients. Mayo Clin Proc 2012;​87:​63-6.
3. Sunderamoorthy D, Smith A, Woods man MD, Hallmark N, Cheek S. Somato- 14. Bass C, Halligan P. Factitious disor-
DA. Recurrent elbow dislocation — an un- form, factitious, and related diagnoses in ders and malingering: challenges for clini-
common presentation. Emerg Med J 2005;​ the National Hospital Discharge Survey: cal assessment and management. Lancet
22:​667-9. addressing the proposed DSM-5 revision. 2014;​383:​1422-32.
4. Waymack JR, An J. Posterior elbow dis- Psychosomatics 2013;​54:​142-8. 15. Rumschik SM, Appel JM. Malingering
location. Treasure Island, FL:​StatPearls, 10. Zubera A, Raza M, Holaday E, Aggar- in the psychiatric emergency department:
2019. wal R. Screening for malingering in the prevalence, predictors, and outcomes.
5. Diagnostic and statistical manual of emergency department. Acad Psychiatry Psychiatr Serv 2019;​70:​115-22.
mental disorders. 5th ed. Washington, DC:​ 2015;​39:​233-4. 16. Catalina ML, Gómez Macias V, de Cos
American Psychiatric Association, 2013. 11. Weiss KJ, Van Dell L. Liability for diag- A. Prevalence of factitious disorder with
6. Parsons T. The social system. Glen- nosing malingering. J Am Acad Psychiatry psychological symptoms in hospitalized pa-
coe, IL:​Free Press, 1951. Law 2017;​45:​339-47. tients. Actas Esp Psiquiatr 2008;​36:​345-9.

770 n engl j med 381;8 nejm.org  August 22, 2019

The New England Journal of Medicine


Downloaded from nejm.org by David Pakpahan on September 1, 2019. For personal use only. No other uses without permission.
Copyright © 2019 Massachusetts Medical Society. All rights reserved.
Case Records of the Massachuset ts Gener al Hospital

17. Rissmiller DA, Steer RA, Friedman M, 21. Kontos N, Taylor JB, Beach SR. The 25. Mojtabai R, Mauro C, Wall MM, Barry
DeMercurio R. Prevalence of malingering therapeutic discharge II: an approach to CL, Olfson M. Medication treatment for
in suicidal psychiatric inpatients: a repli- documentation in the setting of feigned opioid use disorders in substance use treat-
cation. Psychol Rep 1999;​84:​726-30. suicidal ideation. Gen Hosp Psychiatry ment facilities. Health Aff (Millwood)
18. Rissmiller DJ, Wayslow A, Madison H, 2018;​51:​30-5. 2019;​38:​14-23.
Hogate P, Rissmiller FR, Steer RA. Preva- 22. Taylor JB, Beach SR, Kontos N. The 26. Amass L, Pukeleviciene V, Subata E,
lence of malingering in inpatient suicide therapeutic discharge: an approach to et al. A prospective, randomized, multi-
ideators and attempters. Crisis 1998;​19:​ dealing with deceptive patients. Gen Hosp center acceptability and safety study of
62-6. Psychiatry 2017;​46:​74-8. direct buprenorphine/naloxone induction
19. Ekman P. Universals and cultural dif- 23. Gowing L, Farrell M, Ali R, White JM. in heroin-dependent individuals. Addic-
ferences in facial expressions of emotion. Alpha2-adrenergic agonists for the man- tion 2012;​107:​142-51.
In:​Cole J, Lincoln NB, eds. Nebraska agement of opioid withdrawal. Cochrane 27. Manuel JI, Yuan Y, Herman DB, et al.
symposium on motivation. Lincoln:​Uni- Database Syst Rev 2009;​2:​CD002024. Barriers and facilitators to successful
versity of Nebraska Press, 1999:​207-283. 24. Ward EN, Quaye AN, Wilens TE. Opioid transition from long-term residential sub-
20. Ring D, Jupiter JB. Fracture-disloca- use disorders: perioperative management stance abuse treatment. J Subst Abuse
tion of the elbow. J Bone Joint Surg Am of a special population. Anesth Analg Treat 2017;​74:​16-22.
1998;​80:​566-80. 2018;​127:​539-47. Copyright © 2019 Massachusetts Medical Society.

journal archive at nejm.org


Every article published by the Journal is now available at NEJM.org, beginning
with the first article published in January 1812. The entire archive is fully searchable,
and browsing of titles and tables of contents is easy and available to all.
Individual subscribers are entitled to free 24-hour access to 50 archive articles per year.
Access to content in the archive is available on a per-article basis and is also
being provided through many institutional subscriptions.

n engl j med 381;8 nejm.org  August 22, 2019 771


The New England Journal of Medicine
Downloaded from nejm.org by David Pakpahan on September 1, 2019. For personal use only. No other uses without permission.
Copyright © 2019 Massachusetts Medical Society. All rights reserved.

Das könnte Ihnen auch gefallen