Titration goes digital

New digital solutions for titration

Dr Ilona Matus
Life Science | Applied Solutions SMI | Advanced Analytics |
Analytical Sciences Specialist
August 2019
1
Digital Solution for
Mettler Toledo titrators

2 Digital Solution for

Metrohm titrators
 Titration goes digital
A joint project
between
Mettler Toldeo GmbH, Nänikon, Schweiz
&
Merck KGaA, Darmstadt, Germany

3 Titration goes digital | Dr Ilona Matus | Jakarta, Indonesia | August 2019

 Titration today
 Manual data integration from the CoA
and label into the Titrator software
 Control with four eyes principle

disadvantages
− human typing errors
− time consuming process
− writing the first opening date on the bottle
− additional paper documentation

4 Titration goes digital | Dr Ilona Matus | Jakarta, Indonesia | August 2019

Titration of the future
Connect your SmartTitrants & SmartStandards with the titrator.

5
Titration goes digital | Dr Ilona Matus | Jakarta, Indonesia | August 2019
6

Seamless
data transfer
via
Transfer of data for
method execution,
calculation &
documentation
RFID tag Ensures maximum data
integrity

Scan RFID chip

User in the lab
Integrity of the
data from the
titrant and standard
in the instrument
software
Data transfer from
RFID tag on the
Smart Chemicals & reagents bottle to the
Smart Standards with instrument software
RFID tag in one touch
Titrator with scanner
19
Titration goes digital | Dr Ilona Matus | Jakarta, Indonesia | August 2019
7 Titration goes digital | Dr Ilona Matus | Jakarta, Indonesia | August 2019
Product label

8 Titration goes digital | Dr Ilona Matus | Jakarta, Indonesia | August 2019

Products label

9 Titration goes digital | Dr Ilona Matus | Jakarta, Indonesia | August 2019

Product label

10 Titration goes digital | Dr Ilona Matus | Jakarta, Indonesia | August 2019

Read Smart Chemcials – touch the tag

Smart Chemcials with tag External reader Integrated reader

11 Titration goes digital | Dr Ilona Matus | Jakarta, Indonesia | August 2019
 Integrated data

12 Titration goes digital | Dr Ilona Matus | Jakarta, Indonesia | August 2019

Data integrity

Data management & monitoring

• Initial opening date – first opening (on the chip)

• Supplier of the chemicals
• Type of the titration
• Monitoring Life span (expiry date of the solution/standard)
(defined by the customer after opening)
• Shelf life of unopened bottle
• Compliance – according to regulations like EP / USP / ISO
17025 / ISO Guide 34
• Titer & determination date (on burette chip)

Titration goes digital | Dr Ilona Matus | Jakarta, Indonesia | August 2019

13
Product Portfolio
will be introduce until end of 2019

Smart Standards Smart Titrants Smart Titrants in Titripac®

 Certipur® volumetric standards  Titripur® volumetric solutions  Titripur® volumetric solutions

− 11 APNs − ready-to-use solutions in 1 L bottles − ready-to-use solutions in 4 and 10 L
Titripac
− different solutions in different
 Aquastar® Karl Fischer concentrations − different solutions in different
standards − about 120 APNs concentrations
− 8 APNs − about 25 APNs
 Aquastar® Karl Fischer Reagents
− 6 Titrants - 11 APNs
− in 0.5 L / 1 L / 2.5 L bottles

14 Titration goes digital | Dr Ilona Matus | Jakarta, Indonesia | August 2019

Products available

Titripur® Volumetric solutions

1090651003 Perchloric acid in acetic acid 0.1 mol/L
1091141003 Potassium hydroxide solution in ethanol 0.5 mol/L
1091151003 Potassium hydroxide solution in ethanol 0.1 mol/L

Certipur® volumetric standards

1024000083 Potassium hydrogen phtalate
1024010063 Benzoic acid
1024080083 Tris(hydroximethyl)aminomethane
1024090103 Zinc

Aquastar® Karl Fischer Titrants

1880051003 CombiTitrant 5

15 Titration goes digital | Dr Ilona Matus | Jakarta, Indonesia | August 2019

 Further product introductions:

Titripur® Volumetric solutions

1090601003 Hydrochloric acid solution 0.1 mol/L
1090601003 Hydrochloric acid solution 1 mol/L
1090511003 Sodium hydroxide solution 0.1 mol /L
1091371003 Sodium hydroxide solution 1 mol/L
1090811003 Silver nitrate solution 0.1 mol/L
1091471003 Sodium thiosulfate solution 0.1 mol/L
1084311003 Titriplex III solution 0.1 mol/L

Certipur® volumetric standards

1024040103 Potassium iodate
1024060083 Sodium chloride

16 Titration goes digital | Dr Ilona Matus | Jakarta, Indonesia | August 2019

 Further product introductions:

Aquastar® Karl Fischer Titrants

1880021003 CombiTitrant 2
1880011003 CombiTitrant 1
1880061003 CombiTitrant 5 Keto
1880101003 Titrant 5
1880111003 Titrant2

Aquastar® Karl Fischer Standards

1880521013 Water standard 1 %
1880511013 Water standard 0.1 %
1880501013 Water standard 0.01%
1066640103 Sodium tartrate dihydrate 15,66% water

17 Titration goes digital | Dr Ilona Matus | Jakarta, Indonesia | August 2019

Mettler Titrators can be used with Smart Chemicals

30252669 G20S Compact Titrator

30267117 G10S Compact Titrator

30252667 V30S Compact Titrator

30252666 V20S Compact Titrator

30267116 V10S Compact Titrator

30252676 T9 Excellence Titrator

30252675 T7 Excellence Titrator

30252672 T5 Excellence Titrator

30486743 External SmartChemical Redaer

18 Titration goes digital | Dr Ilona Matus | Jakarta, Indonesia | August 2019

Benefits of the new technology of data integrity

Ease of use –
Secure data transfer – intuitive operation and
ensures complete convenient data transfer
and correct reagent data in one touch

Improved efficiency –
fast data transfer - safes
Extended quality time - no manual writing
management – and no four-eyes
titer determination, shelf principle necessary
life, compliance data,
initial opening date

19
Titration goes digital | Dr Ilona Matus | Jakarta, Indonesia | August 2019
 Smart Chemicals are the future of the titration lab! –
Connect your titrator with the smart chemicals!

20 Titration goes digital | Dr Ilona Matus | Jakarta, Indonesia | August 2019

 Titration goes digital
A joint project
between
Metrohm AG, Herisau, Switzerland
&
Merck KGaA, Darmstadt, Germany

21 Titration goes digital | Dr Ilona Matus | Jakarta, Indonesia | August 2019

3S Products for Volumetric Titration
Suitable for use with Metrohm’s OMNIS platform for potentiometric titration

Safe bottle opening

3S
Safe Smart
Minimized risk of contamination
Secure
✓ Enhanced Safety

Smart data transfer

Automated communication to instrument
✓ Enhanced ease-of-use

Secure data transfer

Of reagent data to instrument software
✓ Enhanced quality

Joint development project with Metrohm

22 Titration goes digital

Digital |- Dr
3S Ilona
reagents
Matus
for| Metrohm
Jakarta, Indonesia
Omnis platform
| August 2019
3S Adapter Technology
Closed end-to-end solution for chemical consumables

What is it?
• Ready-to-use volumetric solutions
Omnis software
• RFID chip on the cap
recognizes connected
• Absorber cartridge integrated
reagent automatically
How to use
• Cut open membrane (push down)
• Connect to instrument with single hand movement
• Automated transfer of reagent data

23 Titration goes digital

Digital |- Dr
3S Ilona
reagents
Matus
for| Metrohm
Jakarta, Indonesia
Omnis platform
| August 2019
3S Adapter Technology
Life cycle of single-use bottle cap Open & Connect
Membrane opened
Automatic data transfer
Originality seal
Membrane closed

2
1
Store after use

3
Lid closed

Remove cap after use

RFID Chip destroyed
4

24 Titration goes digital

Digital |- Dr
3S Ilona
reagents
Matus
for| Metrohm
Jakarta, Indonesia
Omnis platform
| August 2019
Available 3S Products
Volumetric titration solutions sealed with 3S cap

Product Brand Supelco

Description Cat.No.

Silver nitrate solution 3S, 0.1 M (1L) 1506891000

Perchloric acid solution in glacial acetic acid 3S, 0.1 M (1L) 1506951000

Hydrochloric acid solution 3S, 1 M (1L) 1506961000

Hydrochloric acid solution 3S, 0.1 M (1L) 1506771000

Iodine solution 3S, 0.05 M (1L) 1506901000

Sodium thiosulfate solution 3S, 0.1 M (1L) 1506911000

Sulfuric acid solution 3S, 0.25 M (1L) 1506921000

Cerium(IV) sulfate solution 3S, 0.1 M (1L) 1506931000

Further products under development

25 Titration goes digital

Digital |- Dr
3S Ilona
reagents
Matus
for| Metrohm
Jakarta, Indonesia
Omnis platform
| August 2019
Video (YouTube or sial.com/3S)

26 Titration goes digital

Digital |- Dr
3S Ilona
reagents
Matus
for| Metrohm
Jakarta, Indonesia
Omnis platform
| August 2019
Thank you for
your attention!

27 Titration goes digital | Dr Ilona Matus | Jakarta, Indonesia | August 2019