Gustavo Camps-Valls Universitat de València, Spain
Manel Martínez-Ramón Universidad Carlos III de Madrid, Spain
José Luis Rojo-Álvarez
Universidad Rey Juan Carlos, Spain
INTRODUCTION ics (Mukherjee et al., 1998), the applications of these
methods have grown exponentially, and many novel In this chapter, we give a survey of applications of the and powerful methods have been developed (only in kernel methods introduced in the previous chapter. We 2004, more than 1000 papers have been devoted to this focus on different application domains that are particu- topic). The use of kernel methods in computational larly active in both direct application of well-known biology has been accompanied by new developments kernel methods, and in new algorithmic developments to match the specificities and the needs of the field, suited to a particular problem. In particular, we consider such as methods for feature selection in combination the following application fields: biomedical engineer- with the classification of high-dimensional data, the ing (comprising both biological signal processing and introduction of string kernels to process biological bioinformatics), communications, signal, speech and sequences, or the development of methods to learn image processing. from several kernels simultaneously (‘composite ker- nels’). The interested reader can find a comprehensive introduction in (Vert, 2006). KERNEL METHODS IN BIOMEDICINE AND BIOINFORMATICS KERNEL METHODS IN Kernel methods have been extensively used to solve COMMUNICATIONS biomedical problems. For instance, a study of predic- tion of cyclosporine dosage in patients after kidney There are four situations that make kernel methods transplantation using neural networks and kernel-based good candidates for use in electromagnetics (Martínez- methods was carried out in (Camps-Valls et al., 2002). Ramon, 2006): 1) No close solutions exist, and the Recently, (Osowski, Hoai, & Markiewicz, 2004) pro- only approaches are trial and error methods. In these posed a committee of experts formed by several sup- cases, kernel algorithms can be employed to solve the port vector machines (SVM) for the recognition of 13 problem. 2) The application requires operating in real heart rhythm types. time, and the computation time is limited. In these cases, The most impressive results of kernels have been a kernel algorithm can be trained off-line, and used in obtained in genomics and computational biology, due test mode in real time. The algorithms can be embedded to both the special characteristics of data and the great in any hardware device. 3) Faster convergence rates interest in solving biological problems since the Human and smaller errors are required. Kernel algorithms have genome sequencing. Their ability to work with high shown superior performance in generalization ability dimensional data, to process and efficiently integrate in many problems. Also, the block optimization and non-vectorial string data, make them very suitable to the uniqueness of solutions make kernelized versions solve various problems arising in computational biol- of linear algorithms (as SVM) faster than many other ogy. Since the early papers using SVM in bioinformat- methods. 4) Enough measured data exist to train a
(Lecture Notes in Computer Science 4488) JeongHee Cha, GyeYoung Kim, HyungIl Choi (auth.), Yong Shi, Geert Dick van Albada, Jack Dongarra, Peter M. A. Sloot (eds.)-Computational Science – ICCS 2007_ 7.pdf
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