Aspirin is an antiplatelet agent that improves blood flow and vascular formation in the placenta by

reducing the thromboxane and increasing the vasodilator prostacyclin. “Preeclampsia, of course, is a
disease of the placenta that results from a placenta not developing properly from very early in
pregnancy.

It has the potential to reduce medically indicated preterm birth by reducing the risk of preeclampsia,
small for gestational age, and placental insufficiency (9) and spontaneous preterm birth by decreasing
uterine contractility and inflammation via cyclooxygenase inhibition.

Tes Diagnostik

(1) women with a singleton pregnancy, (2) hospitalized for TPL between 24 and 34 weeks
gestational age with symptoms indicating threatened preterm delivery based on the presence of
regular uterine contractions and intact membranes with possible cervical change but without
advanced cervical dilation (< 3 cm), (3) with a preterm delivery (PTD) occurring within 7 days of
the initial hospitalization, and (4) without severe maternal disease such as severe gestational
arterial hypertension, pre-eclampsia, eclampsia, premature preterm rupture of the membranes,
and placenta previa, or cases of termination of pregnancy for maternal and fetal medical
reasons.
(2) Fetal fibronectin is a protein that's believed to help keep the amniotic sac "glued" to the lining of
the uterus. The amniotic sac is the fluid-filled membrane that cushions your baby in the uterus.
If this connection is disrupted, fetal fibronectin can be released into secretions near your cervix.
The connection can be disrupted by an infection, inflammation, the separation of the placenta
from the wall of the uterus, uterine contractions or shortening of the cervix. Periksa saat
kehamilan 24 minggu atau lebih.

Gejala PTB:

In addition to painful or painless uterine contractions, symptoms such as pelvic pressure, menstrual-
like cramps, watery vaginal discharge, and lower back pain have been empirically associated with
impending preterm birth. Such complaints are thought by some to be common in normal pregnancy
and are therefore often dismissed by patients, clinicians, and nurses.

Progesterone is a natural steroid produced by the corpus luteum

and the placenta, whereas 17-hydroxyprogesterone caproate is a
synthetic steroid. These authors reviewed the basic science of natural
and synthetic progestins vis-à-vis effects on the uterus and
cervix in pregnant women, animals, and in vitro experiments.
For example, natural progesterone suppresses myometrial contractility
in strips that were obtained at cesarean delivery, whereas
synthetic 17-OHPC did not. This report is an excellent source of
information on the issues involved with progestin use in preterm
birth.