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Leg Pain Diagnosis

The evaluation of leg pain always begins with the health-care practitioner interviewing the patient and
performing a physical examination to help determine the potential cause of the leg pain and what direction
testing may need to take to confirm a diagnosis.

Blood tests

Infection and inflammation may be detected by blood tests, including a white blood cell count,
an erythrocyte sedimentation rate (ESR), and aC-reactive protein (CRP) measurement. These are
nonspecific tests that may give further direction to the health-care practitioner. Please note that the white
blood cell count may be elevated with an infection unless the patient has some immune compromise, at
which point it may be falsely normal. The ESR and CRP, if elevated, need to be interpreted in light of the
specific illness that is being considered.

If gout is a consideration, a blood test to measure uric acid may be done; however, in the acute attack,
the uric acid level may be high, low, or normal. The result is helpful if the level is high and may confirm a
gout flare if supported by the history and physical examination.

Other blood tests may be considered depending upon the underlying medical illnesses being considered.


• X-rays: If there is concern that a fracture or broken bone is present, plain X-rays may be
indicated. As well, X-rays may be taken as a screening to look for fluid in a joint.

• Ultrasound: Ultrasound may be helpful in making the diagnosis of deep vein thrombosis.
Superficial vein thrombosis is usually diagnosed clinically, and no imaging may be required.

• Arterial-brachial index: Arterial blood flow in the legs may be assessed by an arterial-brachial
index, in which blood flow is evaluated at rest and with exercise.

• Arteriogram: If further information is needed about the arteries, anarteriogram may be

performed to look directly at the arterial supply to the legs. This is accomplished by injecting contrast
dye directly into the arteries and watching it flow through the arteries in the legs via X-rays.
Arteriography may also be carried out using CT or MRI studies (see below).
• CT scan: Computerized tomography (CT) may be used in a variety of situations. CT
angiography may be able to take the place of arteriography is some situations to examine blood
vessels. CT may also be used to evaluate bone and joint anatomy, looking for hidden fractures.

• MRI: Magnetic resonance imaging (MRI) may be used to examine the back for the causes of
sciatica to evaluate bones, joints, and soft tissues such as muscles, tendons, and ligaments. MRI
angiography may also be considered in place of formal angiography to evaluate blood vessels in the

• Nerve conduction studies: Nerve conduction studies may be considered to evaluate nerve
function and measure the ability of specific nerves to carry electrical impulses. This is helpful in
deciding whether nerve pain is due to a central cause from the brain or spinal cord or due to a
peripheral nerve injury. (For example, inflammation of the ulnar nerve from hitting your funny bone can
cause the ring and little fingers to go numb.)

• Joint aspiration: If there is concern about infection or inflammation within a joint, a needle may
be introduced to aspirate fluid for analysis. Often this fluid is sent to a laboratory to analyze the white
blood cell count within the fluid (an elevated white blood cell count may signal inflammation), a gram
stain and culture looking for bacterial infection, and crystal analysis looking for uric acid or calcium
pyrophosphate crystals to make the diagnosis of gout or pseudogout, respectively.