THE EXPOSOME SHORT COURSES SERIES

EXPOSOME ADVANCED
LONDON
16-20 SEPTEMBER, 2019

EXPOSOME BASIS: EXPOSOME PRACTICE

EXPOSOME BASIS COURSE:
DATA & ANALYTICS
UTRECHT, THE NETHERLANDS Surf
Summer School
64
Advanced OMIC Profiling and Integration

XP Advanced:
Statistical Methods for
OMICs Profiling and Integration

XP ADVANCED:
STATISTICAL MODELS AND MACHINE LEARNING TECHNIQUES
FOR OMICS PROFILING AND INTEGRATION
IN EXPOSOME RESEARCH

Contact: Dr Marc Chadeau-Hyam m.chadeau@imperial.ac.uk +44(0)207 594 1637



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EXPOSOME BASIS COURSE:

DATA & ANALYTICS
UTRECHT, THE NETHERLANDS Surf
Summer School
64
Advanced OMIC Profiling and Integration

XP Advanced:
Statistical Methods for
OMICs Profiling and Integration

FORMAT
XP ADVANCED will take place at the Academy of Medical Sciences in London from the 16th
September to the 20th September, 2019. Throughout the 5 days, teaching is articulated as
follows: the day starts with lectures introducing the theoretical concepts. These are
subsequently illustrated on the same day by a seminar and a practical session.
LEARNING After XP ADVANCED, students will be:
OUTCOMES • familiar with most OMICs profiling approaches and their extensions
• able to implement these approaches to analyse real data, including in case of
complex study designs
• able to integrate different OMICs data in relation to an outcome of interest using
regression and correlation approaches
• able to infer network topologies for results interpretation and feature selection
• able to perform of validation, sensitivity and stability analyses using resampling
techniques

TARGET

XP ADVANCED will be of interest to academics (students, and researchers), and scientists
AUDIENCE from the industry (pharmaceutical companies, insurance companies, food industries…)
with background experience in analysing high throughput data (e.g. former MEC or Stat-XP
students), and willing to explore further this type of data towards improved
interpretability and integration. Experience in basic statistics, OMICs data and use of R
statistical software is desirable.
Participants should bring their own laptops. Up to 40 participants can register.
REGISTRATION/

REGISTRATION can be done online:
FEES http://www.imperial.ac.uk/school-public-health/study/short-courses/XP-series/
For any question please send an email to:
m.chadeau@imperial.ac.uk
Course fees:
• Early bird registration (until July 15th, 2019)
Academic: £1,000
Non-academic: £1,300
• Standard registration
Academic: £1,200
Non-academic: £1,500

CONTRIBUTORS
IMPERIAL COLLEGE LONDON (UK):
DR MARC CHADEAU-HYAM, Reader in Statistical Bioinformatics, Dept of Epidemiology
and Biostatistics. Honorary Reader, Utrecht University.
DR GIANLUCA CAMPANELLA, Honorary Research Fellow, Dept of Epidemiology and

Biostatistics.

DR MARYAM KARIMI, Research Associate, Dept of Epidemiology and Biostatistics

MRS BARBARA BODINIER, Research Assistant, Dept of Epidemiology and Biostatistics.

UNIVERSITY OF PAU ET PAYS DE L’ADOUR, (FR):
PROF BENOÎT LIQUET, Professor in Statistics, Member of LMAP. Affiliated to ACEMS,
Queensland University Technology.

UTRECHT UNIVERSITY (NL):
PROF ROEL VERMEULEN, Professor, Institute for Risk Assessment Sciences (IRAS).
Honorary Professor, Imperial College London.
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA-AGROPARISTECH) (FR):
DR JULIEN CHIQUET, Senior Researcher, Dept of Statistics
INSTITUT PASTEUR (FR):
DR BENNO SCHWIKOWSKI, Group Head, Systems Biology Group

INSTITUT NATIONAL POUR LA RECHERCHE MEDICALE (INSERM) (FR):
DR CYRILLE DELPIERRE, Senior Researcher, Université de Toulouse

VENUE: 170
QUEEN’S GATE, CLOSEST TUBE STATIONS: GLOUCESTER ROAD, SOUTH KENSINGTON

SOUTH KENSINGTON

MONDAY 16, INTRODUCTION: REFRESHER AND MODELLING EXTENSIONS:

SEPTEMBER 9.15-9:30 WELCOME AND REGISTRATION
9.30-12:00 PRE-COURSE SET-UP AND WARM-UP SESSION: Installing required packages
and hands-on real data
Facilitators: B Bodinier, M Karimi
13.00-14:30 LECTURE 1: Exposome in Practice: from OMICs profiling to integration
Speaker: M Chadeau-Hyam
14:30-15:30 SEMINAR: Introduction to Life Course Epidemiology
Speaker: C Delpierre
16:00-18:00 PRACTICALS: Univariate OMICs profiling – mixed models and extensions
Lead: B Bodinier, M Karimi, M Chadeau-Hyam

TUESDAY 17, PLS MODELS AND GROUP PENALISATION:

SEPTEMBER 09:30-11:00 LECTURE 1: Penalisation and group penalisation: theory and
implementation
Speaker: B Liquet
11:15-12:45 LECTURE 2: PLS in Practice: sparse and sparse group extensions
Speaker: M Chadeau-Hyam
14:00-16:00 TUTORIAL: PLS and multi-level PLS
Speaker: B Liquet
16:00-18:00 PRACTICALS: Real-life application of (s-sg)PLS models
Lead: B Bodinier, M Karimi

WEDNESDAY 18, OMICS INTEGRATION AND INTRODUCTION TO NETWORK:

SEPTEMBER 09:00-10:00 LECTURE 1: OMICs integration – objectives and possible approaches
Speaker: M Chadeau-Hyam
10:30 -12:00 TUTORIAL: Introduction to (differential) network models
Speaker: B Bodinier
13:00-14:00 SEMINAR: Introduction to network theory: definition – topology
Speaker: G Campanella
14:00-17:30 PRACTICAL: Individual and differential network inference in R
Lead: B Bodinier

THURSDAY 19, SUB-NETWORK ANALYSES:

SEPTEMBER 14:00-16:00 LECTURE 1: Introduction to Cytoscape and Sub-Network Models
Speaker: B Schwikowski
16:00-18:00 PRACTICAL: Using Cytoscape and LEANR for sub-network models
Lead: B Schwikowski




FRIDAY 20,
SEPTEMBER PENALISED GRAPHICAL MODELS:
09:30-11:00 LECTURE 1: Statistics on network data, graph partitioning, clustering
Speaker: J Chiquet
11:15-12:45 LECTURE 2: Network inference with sparse Graphical models
Speaker: J Chiquet
13:45 -16:00 PRACTICAL: Application of network models using OMICs data
Lead: J Chiquet
16:00-16:45 LECTURE: Advanced Statistics in Exposome Sciences: potential and
perspectives
Speaker: R Vermeulen
16:45-17:00 Q/A & CONCLUDING REMARKS
Speakers: M Chadeau-Hyam - R Vermeulen