Important Drug Dosages & Frequency(NICU)

S.no Generic Names,Dosages & Frequency

1 Acetylcysteine;Available Preparation: 2ml (200mg/ml),
Dose and Administration: Route: as nebulisation, Lung Disease: 0.5mL twice daily,To be diluted with 0.5ml or
required amount of 0.9% sodium chloride and nebulised via CPAP, ETT or mask.
IV Infusion:Paracetamol poisoning: Give 150mg/kg of IV acetylcysteine during the first hour and then 50mg/kg over
the next 4hours, followed by 100mg/kg over 16hours.
2 Aciclovir; Available Preparation: (250mg/10mL inj), I.V Infusion:
1)Herpes simplex treatment:
Corrected Gestational Age Dose Frequency
<30 weeks 20mg/kg/dose every 12 hours
≥30 weeks 20mg/kg/dose every 8 hours
2)Chickenpox (varicellazoster):10-15mg/kg/ every 8hrs for 7days IV over 1hr. Preterm infant less than 33 weeks
gestational age:give usual IV dose every 12hours.
Preparation and Administration:Intravenous:Dilute 2ml of the 25mg/ml aciclovir injection with 8ml sodium chloride
0.9% (to a total volume of 10ml). The resulting solution contains 5mg/ml aciclovir(50mg/10ml). Shake well to ensure
thorough mixing,Infuse over 1 hour.
3 Adenosine;Available Preparation: 2ml(6mg/2ml),
Supraventricular tachycardia (SVT):Initial dose: 100 microgram/kg, increase dose in 50mcg/kg increments every 2
minutes until return of sinus rhythm. maximum dose: 300 microgram/kg/dose, Administered by direct IV injection
followed by a rapid sodium chloride 0.9% flush.PREPARATION: For doses < 0.2ml (600 microgram) solution may be
diluted.Diluent: 0.9% Sodium chloride, Take 1ml Adenosine(3mg/ml) and dilute to 10ml = 300mcg/ml (0.3mg/ml/).

4 Adrenaline (EN);Available Preparation: 1ml(1mg/ml),

1)Nebulisation: 0.5mL/kg/dose,Using 1 in 1000 ampoule only. Dilute to 2-4mL with saline.
2)Acute cardiovascular collapse (bradycardia, CPR): 0.1-0.3 ml/kg of 1:10,000 preparation by IV push, (Repeat dose
every 3-5 minutes as necessary)Preparation: 1:10,000 concentration (1ml Adrenaline +9ml,NS) =10ml. For I.V
Infusion: Usual Dilution: 3mg/kg in 50ml D5W, D10W,NS.
flow rate: 0.1-0.5ml /hr = 0.1-0.5mcg /kg/min.
5 Amikacin;Available Preparation: 100mg,250mg vials,
Dose and Administration: Neonatal:
<29wk: GA
0-7days: 15mg/kg/every 48hrs,
8-28days: 15mg/kg every 36hrs,
>29days: 15mg/kg/every 24hrs,
30-34wk:GA
0-7days: 15mg/kg/every 36hrs,
>8dyas: 15mg/kg/every 24hrs,
>35wk:GA:15mg/kg/every 24hrs,
PREPARATION: Diluent: Water for Injections, Glucose 5%, NS,
Draw up contents of vial, make up to10mg/ml.ADMINISTRATION: Infuse over 20 to 30 minutes.

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 6 Aminophylline:(Inj:Aminophylline 250mg/10ml) Loading dose: 8 mg/kg IV infusion over 30 minutes, or
orally.Maintenance dose: 1.5 to 3 mg/kg/dose orally, or IV slow push every 8 to 12 hours (start maintenance dose 8
to 12 hours after the loading dose). In preterm infants, changing from IV aminophylline to oral theophylline requires
no dose adjustment. Severe acute asthma in patients not
previously treated with theophylline
BY SLOW IV INJECTION: Child: 5mg/kg (max.500mg/dose), to be followed by IV infusion.
Severe acute asthma: BY IV INFUSION: Child 1 month–11 years: 1 mg/kg/hour, adjusted according to
7 Amoxicillin & Pot.Clavulanate;Available Preparation: Vials:300mg inj,600mg (500mg amoxicillin; 100mg
clavulanic acid) powder for reconstitution; Oral: 200+28.5mg/5ml(30ml); Dose and Administration: By
Intravenous: Neonate-0-6days: 30mg/kg every12hours , >7days: 30mg/kg/every 8hrly over 3-4minutes. Oral Dose:
Neonate: 22.5mg/kg/dose 12 hourly,(The dose is calculated with regard to the amoxycillin content).Oral
preparation:To make upto 30ml sterile water/SWI,close the cap&shake well untill powder is suspended.For IV:
RECONSTITUTION Co-amoxiclav (GSK, Wockhardt) Reconstitute a 600mg vial with 9.5ml Water for Injection to give
600mg in 10ml solution (Displacement Volume 0.5ml/600mg).This gives a 60mg in 1ml solution,DILUTION No further
dilution required;ADMINISTRATION: By slow IV injection over 3-4 minutes,Solution compatibility:Sodium chloride
0.9%(NS) ,
Solution Incompatibility:Glucose 5%, Glucose 10% TPN, Intralipid
IV Line Incompatibility:Aminoglycoside antibiotics, Lidocaine, metronidazole, midazolam, sodium bicarbonate.
STORAGE: Oral: After reconstitution keep in 2-8c (refrigerator),use within 7 days.

8 Amphotercin-B Liposomal; Available Preparation: (AMBISOME)50mg vial ,

Systemic fungal infections:Dose: 5 to 7mg/kg per dose every 24 hours.
PREPARATION: 50mg vial, Reconstitute by adding 12 ml of sterile water for injection to a yield a concentration of
4mg/ml. Immediately shake vial vigorously for 30 seconds. Check for complete dispersion. Reconstituted suspension
stable for 24 hours refrigerated. Do not freeze. Protect from light. Before administration, AmBisome® must be
diluted with D5W to a final concentration less than 2mg/ml. ADMINISTRATION: IV infusion by syringe pump over 2
hours.If line requires flushing use glucose solutions only. Do not use solutions containing sodium chloride(NaCl).

9 AMPHOTERICIN B; Available Preparation:50mg vial(inj:Amphotin 50mg,sodium deoxycholate),Dose: IV Infusion: 1

to 1.5 mg/kg(0.5mg/kg On D1,1mg/kg D2 then 1.5mg/kg D3) every 24 hours. Preparation: Available as powder for
injection in 50-mg vials. Reconstitute with 10mL of D5W or preservative free sterile water to a concentration of
5mg/mL,then dilute further using D5W to a concentration no greater than 0.1mg/mL for infusion. Reconstituted
solution stable for 24 hours at room temperature or 7 days in refrigerator.Do not flush IV or mix Amphotericin- B
with saline solution(NS); precipitation will occur. ADMINISTRATION: IV infusion over 2 to 6 hours.

Amphotericin B 50mg vial: Nebulisation reference: Nebulizing

The amphotericin mixture needs to be further diluted before nebulizing. Sterile;Water for Inhalation unit dose
packets are used for this purpose.
1. Sterile Water for Inhalation 2.5ml (1/2 packet) is poured into the medicine reservoir of the nebulizer.
2. Then draw up 0.5 mL (2.5mg) of amphotericin B with a 3mL syringe and put into the Sterile Water for Inhalation in
the nebulizer cup.
3. Gently swirl to mix. Do not use saline (salt water) to mix with amphotericin, because it is not compatible.
4. Put the nebulizer together and start the treatment.
5. Discard the remaining Sterile Water for Inhalation packet.
6. You have been instructed to nebulize 2.5mg (0.5ml) of amphotericin 2 times daily.Ref by:Copyright © 3/2017
University of Wisconsin Hospitals and Clinics Authority.

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 10 Ampicillin: 500mg vial , BY INTRAVENOUS INFUSION

Listerial meningitis: 100mg/kg/dose. Dosing interval as per table below

▶:Standard infections: 50mg/kg/dose. Dosing interval as per table below
CGA Postnatal age Dose Frequency
<30 weeks 0-28 days 50mg/kg 12 hourly
≥29 days 50mg/kg 8 hourly
30-36 weeks < 14 days 50mg/kg 12 hourly
≥15 days 50mg/kg 8 hourly
37-44 weeks 0-7 days/>7 50mg/kg 12 hour/8hour
≥45 ALL 50mg/kg 6 hourly
Preparation/Dilution:IV: Add 4.7ml of water for injection to the 500mg vial for reconstitution to make 100mg/ml
solution. FURTHER DILUTED: Draw up 5ml (500mg of ampicillin)of solution and add 5ml sodium chloride 0.9% to
make a final volume of 10ml with a concentration of 50mg/mL solution.Administration:IV: Infusion over 5−10
minutes into the proximal cannula site with a max rate of 100mg/minute.Separate from aminoglycosides by clearing
the lines with a flush as ampicillin inactivates them. Higher doses should be diluted to 30mg/ml and infused over 30
minutes.
11 Atropine Sulphate; Available Preparation: 1ml (0.6mg/ml),
Dose and Administration:
Premedication: IM: 10 -20 microgram/kg/dose,IV: 10 -30 microgram/kg/dose
Bradycardia: IV or IM: 10 – 30 microgram/kg/dose ,
PREPARATION: Dilute 1ml (600microgram) with 5ml Water for Injections,(600 mcg in 6ml,100 mcg/ml).
ADMINISTRATION:Intravenous: Over 1 minute,Dose may be repeated every 10 -15minutes to achieve desired
effect. Maximum total dose 40microgram/kg.
12 Azithromycin, Available Preparation: (Syp:100mg,200mg/5ml,iv:500mg vial).
DOSE: ORAL: 1)For Pertussis infections: 10mg /kg /dose once daily for 5 days;2)For Chlamydia trachomatis,
conjunctivitis, pneumonitis:20mg/kg/dose once daily for 3 days.
Prophylaxis CLD dosing : < 25kg weight : 30mg/kg per week (may be given in divided doses on a daily basis, three
times weekly or as a single weekly dose,Ref By:Children’s Health Queensland) PREPARATION: Diluent:
Water for Injections, ORAL: Give on empty stomach.

13 Budesonide; Available Preparation: 0.5mg/2ml,Respules; Bronchopulmonary dysplasia (BPD): Starting Dose:

0.5 mg (500mcg)/every 12 hourly(BD) for six weeks until improved and stable. Usual maintenance dose: 0.25 mg 12
hourly. If no response increase to 0.5 mg 12 hourly.
14 Caffeine Citrate; Available Preparation:3ml( 20mg/ml), Neonatal apnoea: IV/Oral: Loading dose: 20 to 25
mg/kg of caffeine citrate IV over 30 minutes or orally.(Equivalent to 10 to 12.5 mg/kg caffeine base). Maintenance
dose: 5 to 10mg/kg/dose of caffeine citrate IV slow push or orally every 24 hours. (Equivalent to 2.5 to 5 mg/kg
caffeine base).Maintenance dose should be started 24 hours after the loading dose. PREPARATION: Intravenous
doses may be given undiluted, or diluted with compatible fluid for ease of administration. Compatible Fluids:Glucose
5%, glucose 10%, sodium chloride 0.9%. ADMINISTRATION: IV loading doses as an infusion over at least 30
minutes.IV maintenance doses as a bolus injection over at least 3 minutes. Oral: Give dose with feeds.

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 15 Calcium Gluconate:Available Preparation: Ampoule: 1g in 10mL, (10%)
(calcium gluconate 100mg/ml, equivalent to elemental calcium 9.3mg (0.465 mEq) ):
1)Neonatal Symptomatic Hypocalcemia (eg, increased neuromuscular irritability/activity, seizures),Acute
treatment:100 to 200 mg/kg/dose (1 to 2 mL/kg/dose, equivalent to 9.3 to 18.6mg/kg elemental calcium) .Dilute in
D5W, then infuse in IV over 10 to 30 minutes while monitoring for bradycardia.
Maintenance dose: 180 to 720 mg/kg/day (2 to 8ml/kg/day, equivalent to 18.6 to 74.4mg/kg elemental calcium)
.Administer by continuous IV infusion. Treat for 3 to 5 days .May also be given orally in the same dose.PICC Line: 5-
8ml/kg/day. PREPARATION: For continuous infusion: Withdraw 5ml/kg of 10% calcium gluconate. Dilute to 25ml
with D5W. ADMINISTRATION: Administer by slow IV push for cardiac arrest; infuse over 30 to 60 minutes for other
indications . May dilute in D5W for intermittent or continuous infusion. Infusion through central line is preferred.
Administer slowly as bolus,about 1.5 ml over 1 minute , do not exceed 2ml/min as an intermittent infusion or
continuous infusion . Administer into a large vein through a small needle to avoid hypercalcemia, extravasation, and
necrosis .Not for IM or subQ use. Solution Compatibility : D5W, D10W, and NS.

16 Syp:Calcimax plus(+),200ml; strength: Each 5ml=elemental calcium=250mg, elemental

magnesium=75mg,elemental Zinc=2mg,Vit D3=200 IU;(1ml=50mg calcium),Dose: elemental calcium: 20 to
80mg/kg/day orally in divided doses scheduled around oral feedings (0.4 to 1.6ml/kg/day).
17 Syp:Calcimax-P, 200ml; strength: Each 5ml=elemental calcium=150mg, elemental
magnesium=37.5mg,elemental Zinc=2mg,Phosphorus 75mg,Vit D3=100 IU;(1ml=30mg calcium) Dose: elemental
calcium: 20 to 80mg/kg/day orally in divided doses scheduled around oral feedings.(0.67 to 2.67ml/kg/day)Calcium
deficiency: BY Mouth : Neonate: 0.25 mmol/kg 4 times a day, adjusted according to response.

18 Caspofungin;Available Preparation: 50mg,70mg inj,Dose: Neonate&Child 1-2months: 25mg/m2 (1-2mg/kg)

once daily over 1hour.
PREPARATION: Diluent: SWI/NS, Intravenous: Add 10.5ml of diluent to a 50mg vial = 5.2mg/ml (must be further
diluted)Further dilute this concentrated solution to 0.5mg/mL or weaker with NS(sodium chloride 0.9%).
ADMINISTRATION: For intravenous infusion.Infuse over 60 minutes.
Caspofungin is incompatible with glucose.
19
CefaLEXin,Sporidex drops 10ml(100mg/ml); Syp:Phexin 125mg
Treatment of mild infections due to susceptible strains of bacteria.
Prophylaxis of urinary tract infections in patients at risk (e.g., vesicoureteric reflux).Treatment:
Postnatal Age (Days) Dose Interval
0─7 days 25 mg/kg 12 hourly
8─28 days 25 mg/kg 8 hourly
29+ days 25 mg/kg 6 hourly
Prophylaxis: 12.5 mg/kg/dose DAILY(Night)
20 Cefotaxim,500mg,1gm. DOSE: 50mg/kg/dose IV 12H (preterm),8H(1st wk life),6H(2-4 wk).PREPARATION:
use the following process to prepare a 100mg/mL solution.Add 9.6 mL Water for Injections(SWI) to 1 g vial =
100mg/mL, IM: Add 3.4 mL (SWI) diluent to 1 g vial 300mg/mL. ADMINISTRATION: IV Injection: over 3-5 minutes,
IM Injection: As per NICU policy.
21 Ceftazidime IP 1gm vial, Dose: Age: < 7 days: 30mg/kg/dose 12 hourly,>7 days 30mg/kg /dose 8 hourly,Severe
infection: < 7 days: 50mg/kg/dose 12 hourly. >7 days: 50mg/kg/dose 8 hourly. PREPARATION:Intravenous:Add
8.9ml Water for Injections(SWI) to vial = 100mg/ml; Intramuscular: Add 3ml Water for Injections (SWI) or 1%
lignocaine to a vial = 260mg/ml, ADMINISTRATION: IM: As per NCCU policy.Intravenous: over 3-5minutes.

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 22 Clindamycin USP 300mg(300mg/2ml) ,DOSE: All pre-term and <7 days
5 mg to 7.5 mg/kg/dose every 12 hours
≤ 29weeks, >28days 5 - 7.5mg/kg/dose 8 hourly
30-36weeks >14 days 5 - 7.5mg/kg/dose 8 hourly
37-44 weeks > 7 days 5 - 7.5mg/kg/dose 8 hourly.Severe inftn (>28 days): 15-20 mg/kg 8H IV over 1hr. Acne soltn
1%: 12H.PREPARATION:Withdraw 150mg (1mL) and dilute to 30mL= 150mg/30mL,= 5mg/mL.May be further diluted
if required
Diluent:NS&D5W, ADMINISTRATION:Intravenous infusion over 30 minutes.
23 Colistimethate Sodium 10Lakhs units/1MU, DOSE:40,000IU/kg/dose 8H, Preparation: 1 vial(1MU)
dilute in 10ml of sterile water for injection, after dilution each 1ml=100000 IU(1lakh),0.4ml/kg/dose further dilute
to 30ml of D5W. IV infuse over 1hour. Inhaled Dose: 30,000-60,000 u/kg/dose 8H. Reconstitution for Inhalation:
The required amount of powder is dissolved, preferably, in 2-4 mL of NS solution and poured into the nebulizer.
Alternatively, water for injections may be used. Ref:Frankshann drug doses

24 Co-trimoxazole(Trimethoprim(TMP)&Sulphamethoxazole(SMX)) (Syp:200+40/5ml,iv:400+80mg/5ml ). Dose:IV:

Trimethoprim 3mg/kg /dose, Sulphamethoxazole(TMP) 15 mg/kg/dose 12 hourly. Oral: Treatment: 0.3 - 0.5 mL/kg
/dose 12 hourly Equivalent to:Trimethoprim 2.4 – 4mg/kg/dose -Sulphamethoxazole 12 - 20mg/ kg/dose 12
hourly.Prophylaxis: 0.25ml/kg/dose at night oral. PREPARATION: IV Infusion: Take 1ml from ampoule(16/80mg).
Dilute to 25ml (with D5W).Now 25ml contains 16mg TMP& 80mg SMX.Withdraw required dose from the diluted
solution.ADMINISTRATION: Intravenous infusion over 60 minutes.Oral: May be given with or after feeds.

25 Clotrimazole 1% mouth paint 20ml: Topical: 1% cream or solution 8-12H.

26 Inj: DEXMEDETOMIDINE 100mcg,200mcg(1ml,2ml)
All Indications: IV: > 36 weeks CGA: Loading Dose: 0.05 – 0.2 microg/kg over 30 minutes
Maintenance Dose: 0.05 to 0.6 microgram/kg/hour
Dosing should be tapered after 24 hours as tolerance may develop and not given for longer than 2-3 days.
Monitoring: Monitor heart rate,MAP,CVP,blood pressure,oxygen saturation,respiratory rate,urine output
Preparation: Compatible Fluids: Sodium chloride 0.9%(NS) or glucose 5%(5%D)
IV Infusion:Dilution: Dilute 50 mcg (0.5mL) with 49.5 mL of appropriate infusion fluid
Final concentration is 1mcg/mL; Ref by:KEMH & PCH Pharmacy / Neonatal Clinical Care Unit

27 Dexamethasone Sodium Phosphate 2ml (Inj:8mg/2ml)

For Chronic Lung Disease: (DART-Regimen)
Time Dose Frequency
Days 1 to 3 0.075mg/kg/dose 12-hourly
Days 4 to 6 0.050mg/kg/dose 12-hourly
Days 7 and 8 0.025mg/kg/dose 12-hourly
Days 9 and 10 0.01mg/kg/dose 12-hourly
For subglottic oedema: 0.15 mg/kg/dose IV, PO 8 hourly for 3 doses.
First dose administered approximately 4 hours before the scheduled extubation. PREPARATION: Draw up 0.5 mL (2
mg) of drug and dilute to 20mL with Water for Injections = 100microgram /mL, calculate the dose as per body
weight, ADMINISTRATION: IV Push: over 3-5 minutes.
28 DIAZOXIDE (Proglycem 30ml Susp:50mg/ml): For hypogylcaemia: Initial dose is 5-10mg /kg/day in 2-3 doses, For
hypoglycaemia secondary to hyperinsulinaemia: 10-15mg/kg/day in 8-12 hourly. For severe hypertension: 1-
3mg/kg Can be given every 5-15 minutes. Dose is titrated according to blood pressure response Concurrent
administration of a diuretic (e.g. hydrochlorathiazide) is recommended.

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29 Digoxin; Oral: 60ml (50mcg/1ml); IV: 2ml (500mcg/2ml); Loading dose is especially recommended when
treating arrhythmias.Give over 24 hours as 3 divided doses: Initially half of the total dose is given, then quarter of
total dose every 8-12 hours x 2. Administer by slow IV infusion over 30 minutes.
Postmenstrual Age (weeks) Total Loading Dose
IV (mcg/kg) PO (mcg/kg)
≤29 15 20
30 to 36 20 25
37 to 48 30 40
≥49 40 50

Postmenstrual Age (weeks) Maintenance Dose Interval

IV(mcg /kg) PO(mcg/kg) hrs
≤29 4 5 24 hrs
30 to 36 5 6 24 hrs
37 to 48 4 5 12 hrs
≥49 5 6 12 hrs.
30 Dobutamine Hcl 5ml( 50 mg/ml), Dose range: 5-25 micrograms /kg/minute by continuous IV infusion. Usual
Dilution: 30 mg/kg(0.6 ml/kg) Dobutamine to make 50 ml with NS or D5W. flow rate= 0.5 -1ml/hour = 5-10
micrograms/kg/min.
31 DOMPERIDONE: Oral suspension: 1mg/mL, Dose range: 100 to 300microgram//kg/dose(0.1-0.3mg/kg/dose) 4 to 6
times daily.ADMINISTRATION: Give prior to feeds.
32 Dopamine Hcl 5ml(40mg/ml), Dose range: 5-20 micrograms/kg /minute by continuous IV infusion, Usual
Dilution: 30 mg/kg (0.75 ml/kg) Dopamine to make 50 ml with Normal Saline(NS) or D5W, flow rate= 0.5-1ml/hour =
5-10 micrograms /kg/minute.
33 Enoxaparin Sodium, PFS 0.4ml,0.6ml(20mg/0.2ml),Enoxaparin:(1mg=100u);Treatment of Thrombosis:
Term/Preterm infants: initial, 1.5mg/kg per dose subQ every 12 hours.
Adjust dosage to maintain anti-factor Xa level between 0.5 and 1unit/mL. It will
usually take several days to attain levels in the target range.
Dosage requirements to maintain target anti-factor Xa levels in preterm infants are quite
variable, ranging from 0.8 to 3mg/kg every 12 hours.
34 Erythromycin ,(Althrocin,Syp:125mg/5ml);
DOSE: Oral: Preterm infants: 10 mg/kg /dose 6 hourly,
Term infants:12.5mg/kg/dose 6 hourly.Treatment of feeding intolerance due to dysmotility: 10mg/kg per dose
orally every 6 hours for 2 days,followed by 4 mg/kg per dose orally every 6 hours for 5 days.Treatment of
pneumonitis & conjunctivitis due to Chlamydia trachomatis:12.5mg/kg per dose orally every 6 hours for 14 days.
Other infections& prophylaxis: 10 mg/kg per dose orally every 6 hours.
By Intravenous:Severe infections when oral route unavailable: 5 to 10 mg/kg per dose IV infusion by syringe pump
over at least 60 minutes every 6 hours.Do not administer IM.
35 FAT EMULSION 20% (SMOF):(1g=5mL of fat emulsion):
Commencing Dose: 5-10mL/kg/day(target 2g fat/kg/day).
Second & ongoing dose: 10-17.5 mL /kg /day (target 3-3.5g fat/kg/day).
3.5g/kg/day is equivalent to 17.5 mL/kg/day. ADMINISTRATION: Do not dilute.IV infusion: Infants<34 weeks: 0.5-
1ml/hour; Infants>34 weeks: 0.5-3mL/hour.

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 36 Fentanyl Citrate 2ml; 50mcg/ml, Preparation1: 2ml=100mcg,Take 2ml in 8ml NS, thus 1ml=10mcg.
Preparation 2:Take 50 mcg (1mL) of fentanyl from an ampoule and make up to 5mL
with a compatible fluid.Concentration is 10 microg/mL fentanyl
IV Infusion:Use Fentanyl 100microg/2mL ampoules to prepare.
Withdraw 50mcg (1mL) of fentanyl per Kg of babies weight and dilute to 50 mL with a compatible fluid. 1 mL/hr
= 1mcg/kg/hour Dose&Administration: IV Infusion: 0.1-0.4ml /kg/hr(1-4mcg/kg/hr).
Dose range&Indications: Sedation and analgesia:1-4 mcg/kg/dose IV slow push,IM.
For intubation, use 4 mcg/kg,Repeat as required (usually every 2-4 hours).
May be given as a continuous infusion: 1-5mcg/kg/hour.
Anaesthesia: 5-50 micrograms/kg/dose.
Minor surgery: 5-20 micrograms/kg/dose.
Major surgery: 30-50 micrograms/kg/dose. Flush before and after administration of fentanyl with NS.
ref:http://www.adhb.govt.nz/newborn/DrugProtocols/Fentanyl
37 Inj:Fentanyl 100 mcg /2mL; Dose and Indications: Analgesia in Self-ventilating Patients
IV Bolus: 0.5 to 1 mcg/kg, a repeat dose may be given at the discretion of the treating consultant
Analgesia and Sedation in Ventilated Patients: IV Infusion: 1 to 5 mcg/kg/hour (titrate to response)
Intubation for Ongoing Ventilation: Intravenous Bolus: 4 mcg/kg/dose
In-Out Intubation for Surfactant Therapy:Intravenous Bolus: 1-2 micrograms/kg/dose
Preparation-1: Fentanyl 4 mcg/mL,Recommended for neonates weighing < 1kg
To make a 25mL syringe: Dilute 2mL fentanyl (100mcg/2mL) with 23mL of compatible fluid (total of 25mL).
Preparation-2: Fentanyl 8mcg/mL,To make a 25mL syringe: For Neonates weighing: 1 to 3kg: Dilute 4mL fentanyl
(100mcg/2mL) with 21mL of compatible fluid (total of 25mL). Preparation-3:
Fentanyl 16mcg/mL;Recommended for neonates > 3kg
To make a 25mL syringe: Dilute 8mL fentanyl (100microgram/2mL) with 17mL of compatible fluid (total of 25mL).
Compatible Fluids: Glucose 5%, glucose 10% (Y-site only), sodium chloride 0.9%(NS)

38 Fluconazole 100ml inj (200mg/100ml); Invasive Candidiasis: 12 to 25 mg/kg loading dose, then 6 to 12
mg/kg/ dose IV/orally.
Invasive Candidiasis Dosing Interval Chart
Gest. Age (weeks) Post Natal (days) Interval (hours)
≤29 0 to 14 48
>14 24
30 and older 0 to 7 48
>7 24
Prophylaxis: 3mg/kg per dose via IV infusion twice weekly, or orally.
A dose of 6 mg/kg twice weekly may be considered if targeting Candida strains with
higher MICs (4 to 8 mcg/mL). Thrush: 6 mg/kg on Day 1, then 3 mg/kg per dose every 24 hours orally.
ADMINISTRATION: Intravenous: Infuse at concentration of 2mg/mL over 1 to 2 hours (maximum rate
200mg/hour).Oral: May be given with or without food. Ref by:NeoFax Essentials 2014.

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 39 Furosemide 2ml inj(10mg/ml)&30ml Drops(10 mg/ml),
<32 weeks: IV: 1mg/kg/dose 24hrly,
Oral: 1-2mg/kg/dose 24hrly.
≥32 weeks: IV: 1mg/kg/dose 12-24hrly,
Oral: 1-2mg/kg/dose 12-24hrly.
By slow IV:Over 3-4minutes.
IV Infusion: Commence at 0.1mg/kg/hour, then double the dose every 2 hours until urine output > 1ml/kg /hour. An
aggressive yet controlled diuresis is usually achieved with a dose below 0.4 mg/kg/hour. However, higher doses up
to maximum of 1 mg/kg/hour have been used in infants.
Preparation: 25mg/kg furosemide to make 25ml with D5W.
1ml/hour = 1mg/kg/hour.
Ref:www.adhb.govt.nz/newborn/DrugProtocols
40 Ganciclovir 250mg,500mg; (Available Preparation: Inj: Natclovir 500mg;Cap:Natclovir 250mg) Dose:
6mg/kg/dose IV every 12 hours. Treat for a minimum of 6 weeks if possible. Reduce
the dose by half for significant neutropenia (less than 500 cells/mm3).
Chronic Oral Suppression: 30 to 40 mg/kg/dose orally every 8 hours.
Administration: Solution Compatibility(Diluent fluids): NS, D5W,& LR. Reconstituted solution in the vial is stable at
room temperature for 12 hours. Do not refrigerate, may cause precipitation Use proper procedures for handling
and disposal of chemotherapy; drug is potentially carcinogenic and mutagenic. Terminal Injection Site
Incompatibility: Fat emulsion. Aztreonam, cefepime, and piperacillin/tazobactam;
Intravenous: Infuse over a period of 1 hour in compatible solution at a concentration < 10mg/mL .

41 G-CSF (FILGRASTIM);Available Preparation: Inj:Neukine PFS(300mcg/ml); Inj:Neupogen1ml vial (0.3mg/ml);

Indications:1)Neonatal neutropenia: DOSE:10 mcg/kg, daily. Discontinued if WBC count exceeds 50X109/L (BNF).
2) for AML: DOSE: 5 mcg/kg/day subcutaneous injection , short intravenous infusion (15 to 30 minutes) , or
continuous intravenous infusion. Preparation: diluted in 5% Dextrose Injection, from a concentration of 300mcg/ml
to 5 mcg/ml ( from 5 mcg/ml to 15 mcg/ml).
Do not dilute with saline at any time because the product may precipitate.
Ref: NEUPOGEN leaflet, (BNFC-2016).

42 Gentamicin Sulphate;Available Preparation: 2ml(40mg/ml):

1) <29wk gestational age: (Neonatal):
0-7days: 5mg/kg/dose every 48hrs,
8-28days: 4mg/kg/dose every 36hrs,
>29days: 4mg/kg/dose every 24hrs;
2)30-34wk: gestational age:
0-7days: 4.5mg/kg/dose every 36hrs,
>8dyas: 4mg/kg/dose every 24hrs,
3)>35wk: gestational age: 4mg/kg/dose every 24hrs.
PREPARATION: to prepare a 10mg/mL solution,Take 2mL and dilute to 8mL NS.
ADMINISTRATION: IV Infusion: Give over 10 minutes.
43 Glycopyrolate: Available Preparation: Tab:1mg,2mg; IV: 0.2mg/1ml;
DOSE: IV/IM: 4– 10 microgram/kg /dose every 3 to 4 hours. Oral: 40-100microgram/kg/dose 3 to 4 times
daily. ADMINISTRATION: Oral: May be given at any time with regard to feeds.

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44 Glucagon;Available Preparation: 1ml (1mg/ml):
To treat hypoglycaemia:Dose: IV, IM, SC: 200microgram/kg (Max Dose 1mg),Dose may be repeated in 20 mins if
required.Intravenous Infusion: 5-20 microgram/kg/hour.
PREPARATION:Dilute the contents of reconstituted vial to 50ml with D5W solution to make a 1000 microgram
/50ml solution. flow rate: 0.5ml/kg/hour = 10 mcg/kg/hour.
ADMINISTRATION: Intravenous: over 3-5 minutes,
Intravenous infusion: Begin with 0.5-1ml/hour(10 to 20 mcg/kg/hour);
45 HMF Sachet ( Human Milk Fortifier)
Each 1 g of powder contains protein 0.25 g, fat 0.04 g, carbohydrate 0.58 g, multi vitamis &minerals. Human Milk
Fortifier (HMF) protein source is whey (milk) protein concentrate. It contains milk and soy products.Preparation:1)
Pour 25ml of human milk into sterile container. 2) Add entire content of one sachet(1gm) to the container.Cap the
container,shake well & feed.3) Cover & store unused fortified human milk in refrigerator. Use fortified human milk
within 8hours of preparation.4) Shake well before use.

46 Heparin Sodium 5ml (5000 IU /5ml), Maintenance of patency of arterial and/or central venous catheters:
Continuous infusion: 0.5 unit/ml ,In IVN solutions - all solutions contain 0.5 units/ml.
Intermittent heparin flushes: use 0.7ml of 10U Heparin per ml flush after each medication.After insertion, flush
with 0.5ml of 10U/ml Heparin.Full dose heparinisation for anticoagulation: Loading dose 75units/kg by IV injection
over 10 minutes. maintenance dose at 28units/kg/hour by continuous intravenous infusion and titrate dose by
assessment of clinical effects. Preparation: 500u/kg in 50ml Diluents 1ml/hr=10u/kg/hr (i.e, for 1kg wt,1000u/ml,
0.5ml in 49.5ml Diluents (NS,5D)Flow rate: 1ml/hr =10u/kg/hr).
47 Hepatitis B Immune Globulin (Human),Inj:1ml,2ml,(100IU/1ML); Dose: 0.5 ml IM in the anterior-lateral
thigh.
1) Term and preterm newborns born to HBs Ag-positive mother:Give within 12 hours of birth.
2) Term and preterm newborns born to HBs Ag status unknown mother with BW > 2000gms: Give as soon as it is
determined that the mother is HBsAg-positive, within 7 days of birth.
3) Preterm newborns born to HBs Ag status unknown mother with BW <2000gms:
give within 12 hours of birth. When given at the same time as the first dose of hepatitis B vaccine, use a separate
syringe and a different site.Care should be taken to draw back on the plunger of the syringe before injection to be
certain the needle is not in a blood vessel.
Preparation: Refrigerate, Supplied in 1-ml and 2-ml single-dose vials
Use within 6 hours after vial has been entered.
48 Hydrocortisone Sodium succinate 100mg vial,Oral:5mg,10mg, DOSE: 1)Physiological Replacement:
Oral : 8 to 18 mg/m2 per day divided into 3 doses, IV: 8 to 18 mg/m2 per day divided into 4 hourly doses,2)Relative
Adrenal Insufficiency: Term neonate >35/40 gestation: 1mg/kg/dose 6-8 hourly. Preterm neonate <35/40
gestation: 1mg/kg/dose 12 hourly.Stop if random cortisol >414nmol/L. Use for least possible duration,until stable
off inotropes. Usually 2-5 days. 3)Intractable hypoglycaemia: IV/ Oral:1-2mg/kg/dose 6 hourly. PREPARATION:
Diluent:WFI/NS; Add 1.5mL of diluent to each vial, then withdraw and dilute to 2mL= 100mg/2mL May be further
diluted if required, that is, take 2mL of the above solution and dilute it to 10mL = 10 mg/mL, ADMINISTRATION: IV:
Over 3-5 minutes,Oral: Given with or immediately after feeds.*BSA (m2) = (0.05 x kg)+0.05.

49 Hydrochlorthiazide Tab:12.5mg, Dose: 1-2mg/kg/dose every 12 hours.

50 Hydroxyzine Hcl(Drops 15ml:6mg/ml;Syp 100ml:10mg/5ml) Dose:0.5-2 mg / kg/dose 6-8 h oral.

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 51 Hydroxocobalamin: 1) Macrocytic anaemia without neurological involvement:▶ By IM Injection:▶ Child:
Initially 0.25–1mg 3 times a week for 2 weeks,then 0.25 mg once weekly until blood count normal,then 1 mg every 3
months
2)Macrocytic anaemia with neurological involvement:
▶ By IM Injection:▶ Child: Initially 1mg once daily on alternate days until no further improvement, then 1mg every
2 months.Prophylaxis: Child:1mg every 2–3 months.
3)Leber’s optic atrophy:▶ By IM Injection:▶ Child: Initially 1mg daily for 2 weeks, then 1mg twice weekly until
no further improvement,then 1mg every1–3months. 4)Congenital
transcobalamin II deficiency:By IM Injection: Neonate&Child: 1mg 3 times a week for 1year, then reduced to 1mg
once weekly,adjusted as appropriate. 5)Methylmalonic acidaemia and homocystinuria:By IM Injection:▶ Child:
Initially 1mg daily for 5–7 days, then adjusted according to response to up to 1mg 1–2 times a week.6)Poisoning
with cyanides:By IV infusion;▶ Child(Weight 5kg&above): Initially 70mg/kg (max:5gm/dose), to be given over 15
minutes, then 70mg/kg (max.5gm/dose) if required, this second dose can be given over 15 minutes–2 hours
depending on severity of poisoning and patient stability. DIRECTIONS FOR ADMINISTRATION:For IV infusion,given
intermittently in Sodium chloride 0.9%, reconstitute 5gm vial with 200mL NS; gently invert vial for at least 1 minute
to mix (do not shake).injection solution may be given orally; it will not have prolonged effect via this route.

52 Ibuprofen (Ibuprofen lysine) 20mg/2 ml: Closure of patent ductus arteriosus(PDA). 5-10mg/kg 4-8H oral.
PDA: 10mg/kg stat, then 5mg/kg after 24 and 48 hr IV over 15min.IV: Post-
natal Age Day 1 Day2 Day3
< 72 hours 10mg/kg/dose 5mg/kg/dose 5mg/kg/dose
≥ 72 hrs(Higher dose) 20mg/kg/dose 10mg/kg/dose 10mg/kg/dose
≥ 72hrs (lower dose) 10mg/kg/dose 5mg/kg/dose 5mg/kg/dose
Consider a second course 4-days later if duct does not close within 48 hours of the last dose or if it re-opens.

53 Indomethacin; 1mg dry powder vial, Dose: Closure of Ductus Arteriosus:

Usually three doses per course, maximum two courses. Give at 12- to 24-hour intervals, with close monitoring of
urine output. If anuria or severe oliguria occurs, subsequent doses should be delayed.
Longer treatment courses may be used: 0.2 mg/kg every 24 hours for a total of 5 to 7
days.
PDA Closure Dose (mg/kg)
Age at 1st dose 1st 2nd 3rd

0.2 0.1 0.1

2 to 7 days 0.2 0.2 0.2

> 7 days 0.2 0.25 0.25

Prevention of Intraventricular Hemorrhage (IVH): 0.1mg/kg every 24 hours for 3
doses, beginning at 6 to 12 hours of age.
Administration:IV infusion by syringe pump over at least 30 minutes to minimize adverse effects on cerebral,
gastrointestinal, and renal blood flow velocities.

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 54 Insulin(soluble insulin;Inj:Human Actrapid 10ml (40u/ml),Inj:Human Insulatard 10ml: Isophane insulin (Human
insulin 40u/ml),Inj:Human Mixtard 10ml(40U/ml): (30% Soluble insulin & 70% Isophane insulin) ; 1.Actrapid Flexpen
3ml(short acting insulin): Each ml contains:100IU(3.5mg)of Human insulin; 2.Novorapid flexpen 3ml(Rapid-acting
insulin): Each ml contains 100IU(3.5mg) of Insulin aspart;3.Insulatard flexpen 3ml (Intermediate-acting): Each ml
suspension contains: 100IU(3.5mg) of Human insulin Dose:Continuous IV infusion: 0.01 - 0.1 U/kg/hr (starting dose
usually 0.05 U/kg/hr).Preparation: 5U/kg in 50ml dilution 0.5-1ml/hr=0.05-0.1U /kg/hr.

55 Intravenous Immune Globulin (Human):(Inj:Iviglobex 0.5gm/10ml; 2.5gm,5gm/100ml)

Usual Dosage: 500 to 750 mg/kg per dose over 2 to 6 hours.
For neonatal alloimmune thrombocytopenia, doses have ranged from 400mg to 1g/kg Most studies have used a
single dose, although additional doses have been given at 24 hour intervals.Administration: Rate of administration
varies by product; refer to the IVIG Product-Specific information.
56 Iron drops 15ml,Trifer drops 15ml,Iron hydroxide polymaltose(Elemental Iron 50mg/1ml);Orofer-XT 15ml
Ferrous Ascorbate (Elimental iron 10mg/1ml). DOSE: Neonate: Prophylaxis: 3mg/kg/day of elemental iron in two
divided doses.Treatment: 6mg/kg/day of elemental iron in two divided doses.
57 Lactulose 3.35gm/5ml, DOSE: laxative :0.5 ml/kg 12-24h oral.hepatic coma:1ml/kg until bowel cleared than 6-8
hr. (Syp:Duphalac 60ml, 100ml).
58 Lansoprazole 15mg, Dose: 0.75 to 1.5mg/kg once daily.
59 Levetiracetam (IV/Oral:100mg/ml,Syp:100ml,IV:5ml vial), This guideline covers in neonates 36 weeks
gestation and over.Loading Dose: 20mg/kg
Maintenance Dose: Intraveous / Oral
Postnatal Age Dose Dosing Interval
< 7 days 10mg/kg q 8h
>7 days 20mg/kg q 12h
Preparation: Take 1mL (100mg) and dilute it to 20mL NS/D5W(5mg/mL).Administration: IV: Infuse over 15 minutes.
Oral: May be given without regards to feedings.The first maintenance dose is to be given 8 hours after the loading
dose.
60 Levocarnitine; inj: 5ml(200mg/ml); Oral:30ml(500 mg/5ml), Dose: Primary Cornitine deficiency: By IV
Infusion:Initially 100mg/kg, over 30min followed by 4mg/kg/hour. By slow IV :up to 100mg/kg/day 2-4 divided
doses over 3-4minutes. Oral: upto 200mg/kg/day in 2-4 divided doses.max:3gm/day. Preparation: dilute with
D5W/NS.
61 levosalbutamol 0.31mg resp, NOTE:Dose reference with respect to SALBUTAMOL
Dose:Bronchodilation: via nebulizer: 0.1 to 0.5mg/kg/dose every 2 to 6 hours.
1 MDI actuation per dose (approx 0.1mg or 100 mcg) every 2 to 6 hours via
MDI with spacer device placed in the inspiratory limb of the ventilator circuit.
Simulated neonatal lung models suggest greater delivery when using a spacer with the
MDI. Use chlorofluorocarbon free preparations when administering to neonates.
Oral: 0.1 to 0.3mg/kg/dose orally every 6 to 8 hours.
Treatment of hyperkalemia: Preterm neonates: 0.4 mg/dose every 2 hours via nebulization until serum potassium
decreases to desired safe level (eg, less than 5 mmol/L) [1] . Consider alternative
potassium-lowering therapies for potassium levels greater than 7.5 mmol/L.
62 Levothyroxine: Dose: Initial Oral dose: 10 to 14 mcg/kg/dose orally every 24 hours.
(37.5 to 50mcg/dose for an average term infant).Dosage is adjusted in 12.5-mcg increments. Always round upward.

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 63 Linezolid 100ml inj(2mg/ml)&Oral:30ml(20mg/ml)susp,Tab:100mg,600mg; Dose: Preterm and <1 week of
age: 10mg /kg /dose every 12 hours, Term or >1 week of age: 10mg /kg /dose every 8th hours. PREPARATION: IV
Infusion: Use undiluted. ADMINISTRATION:IV infusion: Over 30 to 120 minutes.
64 Magnesium Sulphate 50%w/v 2ml(500mg/ml,4mmol magnesium in 2mL), Dose: Hypomagnesaemia:IV:
0.1 - 0.2 mmol /kg /dose 12 hourly(equivalent to 25 – 50mg/kg/dose). Persistent pulmonary hypertension of the
newborn: IV:Loading dose: 0.8 mmol/kg (200mg/kg) over 30 minutes,Maintenance dose:0.08 - 0.3 mmol/kg/hour
(20 – 75mg/kg/hour) to maintain plasma magnesium concentration between 3.5 – 5.5mmol/L.May be used for up to
5 days. PREPARATION: Infusion:Diluent:D5W/NS,Take 1mL(2 mmol)and dilute to 20mL,(1 mmol in 10mL) May be
further diluted if required Minimum dilutions: IV:Take 1mL (4mmol in 2ml) solution and dilute to 5mL,(0.4
mmol/ml). IM:Take 1mL(4mmol in 2ml)solution diluted to 2.5mL,(0.8 mmol/mL). ADMINISTRATION: Intravenous –
over 30-60 minutes.

65 Meropenam,125mg dry powder, Intra abdominal and NON CNS infections:

CGA Postnatal age Dose Frequency
<32 weeks < 14 days 20mg/kg 12 hourly
<32 weeks ≥14 days 20mg/kg 8 hourly
≥ 32 weeks < 14 days 20mg/kg 8 hourly
≥ 32 weeks ≥14 days 30mg/kg 8 hour
Meningitis:
CGA Postnatal age Dose Frequency
<32 weeks < 14 days 40mg/kg 12 hourly
<32 weeks ≥14 days 40mg/kg 8 hourly
≥ 32 weeks All ages 40mg/kg 8 hourly
PREPARATION:To prepare a 25mg/mL solution.
Diluents: WFI,NS,D5W.Add 4.6mL WFI to vial = 25mg/mL, ADMINISTRATION:IV: Infuse over 30 minutes.
66 Metronidazole (Oral:200mg/5ml) , (IV: 500mg/100ml)Dose & Administration:
Loading dose: 15 mg/kg orally or IV infusion by syringe pump over 60 minutes.
Maintenance dose: 7.5 mg/kg/dose orally or IV infusion over 60 minutes. Begin one dosing interval after initial dose.
PMA(weeks) Postnatal(days) Interval(hours)
≤29 0 to 28 48
>28 24
30 to 36 0 to 14 24
>14 12
37 to 44 0 to 7 24
>7 12
≥45 ALL 8
Preparation: Available in 5 mg/mL concentration in (500mg/100mL) single-dose plastic ready-to-use solution
containers.

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 67 Midazolam 5ml (IV:5mg/1ml,5mg/5mL,Oral:2mg/ml), Dose and Administration: Sedation:IV: 0.05 to 0.15
mg/kg over at least 5 minutes. Repeat as required, usually every 2 to 4 hours. May also be given IM.Continuous IV
infusion: 0.01 to 0.06 mg/kg per hour (10 to 60 mcg/kg/hour). Preparation: 3mg/kg in 10ml diluent, 0.1-0.2ml/hr
(30-60mcg/kg/hour).Intranasal: 0.2 to 0.3 mg/kg per dose, Oral: 0.25 mg/kg per dose. Anticonvulsant: Loading
dose: 0.15mg /kg (150 mcg/kg) IV over at least 5 minutes, followed by Maintenance infusion: 0.06 to 0.4mg /kg per
hour(1 to 7 mcg/kg per minute). Special Considerations/Preparation: Stable for 24 hours when diluted with NS or
D5W to a concentration of 0.5mg/mL; stable for 4 hours in RL .Injectable formulation is used for intranasal, buccal,
or rectal administration.
Solution Compatibility: D5W, NS, and sterile water for injection. Terminal Injection Site Incompatibility:Fat
emulsion. Albumin, ampicillin, bumetanide, cefepime, ceftazidime, dexamethasone,fosphenytoin, furosemide,
hydrocortisone succinate, micafungin, nafcillin, and sodium bicarbonate. Ref:Neofax

68 Milrinone 10ml(vial:10mg/10ml), Dose and Administration:Short-term (less than 72 hours) treatment of acute
low cardiac output after cardiac surgery or due to septic shock: Loading dose: 75 mcg/kg IV infused over 60
minutes, immediately followed by Maintenance infusion: 0.5 to 0.75 mcg/kg per minute. Premature infants < 30
weeks GA:Loading dose: 135 mcg/kg IV infused over 3 hours,followed by Maintenance infusion: 0.2 mcg/kg per
minute. Preparation: 1.5mg/kg in 50ml of 5%Dextrose/NS: flow rate:1-1.5ml/hr. (0.5-0.75mcg/kg/min).

69 Inj:Morphine; Ampoule=15mg/ml, Dose: 0.05 to 0.2mg/kg/dose IV over at least 5 minutes, IM,or subQ.
Repeat as required (usually every 4 hours).
Continuous infusion:Give a loading dose of 100 to 150 mcg/kg over 1 hour followed
by 10 to 20 mcg/kg/ hour. Solution Compatibility: D5W, D10W, and NS.
For continuous infusions of morphine containing heparin: Use only NS; maximum
morphine concentration 5mg/mL. Terminal Injection Site Incompatibility:
Azithromycin, cefepime, micafungin, pentobarbital, and phenytoin. Ref:Neofax
70 MULTIVITAMINS:Vitamins:A-1500 IU,D-400IU,C-35mg,Iron- 10mg,Thiamine(B1) ...1.5mg,Riboflavin(B2)...
1.2mg,Niacin- 10mg,Pyridoxine(B6) ... 0.5mg/1mL. DOSE:Reference Daily Intakes 1 mL every 24 hours.*Iron product
contains no vitamin B12 due to instability with iron and vitamin C concentrations.
71 3%Nacl(3%Sodium Chloride) 3gm/100ml=0.5mmol/ml, Oral sodium supplements:Usually start at
3mmol/kg/day(6ml/kg/day)additional NaCl Occasional infants will require ≥12mmol/kg/day(24ml/kg/day) NaCl.
IV:To calculate dose,Required mmol of sodium = weight (kg) x 0.6 x {140 – infant’s sodium level (mmol/l)}.NaCl MW
= 58.45, 1g NaCl = 17.1mmol Na, NaCl 3% = 0.51mmol/ml.
72 Naloxone1ml(0.4mg/ml), DOSE: Narcotic over dose:0.1-0.2 mg/kg/dose IM (0.25-0.5ml/kg of 0.4mg/ml
concentration). May also be given IV, intratracheally or subcutaneously.May repeat in 3-5 minutes if no response
during resuscitation. PREPARATION: DO NOT DILUTE, ADMINISTRATION: Give IV over 3 minutes;IM, SC: As per
NCCU policy.Onset of action:IV:within 2-3 minutes,IM/SC: within 2-5 minute

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 73 Nor-adrenaline(Nor-epinephrine)2ml (2mg/2ml): Dose: Septic Shock
GA> 35 weeks: Initial dose, 0.2 to 0.5 mcg/kg/min by IV infusion; titrate every 30 minutes to target blood pressure.
Usual Infusion rate 0.2 to 2 mcg/kg/min; higher rates may be required.Administration:Must be diluted before
infusion and administered via central venous route,at a concentration of 16 to 100 mcg/mL . Avoid the
catheter tie-in technique. Constantly watch the flow rate and never leave patient unattended.Special
Considerations/Preparation:Available for IV infusion in 2mL ampules containing 1mg/mL. Protect ampules
from light. Mix norepinephrine in dextrose solutions (dextrose 5% in water, dextrose 5% in saline) since
dextrose-containing solutions protect against excessive oxidation and subsequent potency loss
Administration in saline alone is not recommended. Final concentration of 100 mcg/mL; Terminal Injection
Site Incompatibility:Aminophylline, amphotericin B conventional colloidal, amphotericin B lipid
complex,azathioprine, diazepam, diazoxide, foscarnet, ganciclovir, indomethacin,
pentobarbital,phenobarbital, phenytoin, sodium bicarbonate, sulfamethoxazole/trimethoprim;Ref:Neofax

74 Ondensetron (Oral:2mg/5ml,IV:4mg/2ml) , Dose and Administration: IV: Prophylaxis 0.15mg/kg/dose;

Treatment: 0.2mg/kg over 5 min,or 0.2-0.5mcg /kg/min. Oral: 0.1-0.2mg/kg 6-
12H.
75 Oseltamivir Phosphate 75ml(60mg/5ml), Dose and Administration: Treatment Dose:<38 weeks: 1
mg/kg/dose twice daily for 5 days,38-40 weeks: 1.5 mg/kg/dose twice daily for 5 days,>40 weeks: 3 mg/kg/dose
twice daily for 5days. A longer duration of therapy may be considered for patients who remain severely ill after 5
days of treatment.May be given with or without food.Preparation: Add 46ml of SWI/ make up the volume with
water up to the mark, close the bottle& shake well to obtain a homogenous suspension. Store: Reconsituted susp
keep in refrigerator at 2-8C &use within 10 days.
76 Paracetamol Bag:1g/100mL,IV(10mg/mL), Syp:120mg/5ml,240mg/5ml, Drops:100mg/1ml; Dose and
Administration: Analgesia:IV Infusion: CGA ≥ 32 Weeks:7.5mg/kg/dose every 8 hours for a maximum of 48 hours,
Preferable to use on an as required (”PRN”) basis.Analgesia/Antipyretic: Oral:

Gestational Age Dose Maximum dose

28 to 32 weeks 10-15mg/kg/dose 30mg/kg/day
>32 weeks 10-15mg/kg/dose 60mg/kg/day. Haemodynamically
significant ductus arteriosis (DA):IV: 25mg/kg loading followed by maintainence 15mg/kg/dose TID for 4-
days.Preparation/Dilution:Intravenous: Use undiluted. Can be diluted to 2 mg/ml for use in ELBW infants using
(NS)sodium chloride 0.9%(5%D) or glucose 5%. If diluted, the solution should be used immediately.Administration:
Intravenous: Administer over 15 minutes via syringe driver.Oral: Can be given with or without feeds. Shake bottle
well before measuring dose. Rectal: Dilute oral mixture 1:1 with water for rectal doses. Low dose suppositories are
not commercially available but can be prepared by selected pharmacy departments.
77 Pheniramine Maleate 22.75mg/ml(Inj:Avil 2ml), Dose and Administration: 0.5-1mg/kg 6-8hr Oral/IV.

78 Phenobarbitone Tab:30mg,60mg,Syp:30ml(5ml=20mg),vial 1ml(200mg); Neonatal Seizures:Loading dose:

20mg/kg/dose. If no response, a further 10- 20mg/kg may be given. Maintenance dose: 3 – 5 mg/kg/dose once
daily commencing 24 hours after loading dose.Neonatal Jaundice: 5mg/kg/dose daily. PREPARATION: IM : Use
undiluted;IV : Dilute 200mg ampoule to 10mL, with Water for Injections = 20mg/mL. ADMINISTRATION:
Intravenous, umbilical arterial / venous: Give over 10 to 15 minutes.

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 79 Phosphorus(P)500mg (Addphos 3.2gm sachet):The solution provides elemental phosphorus 500 mg (16.1
mmol phosphate). In addition each Sachet provides sodium 469 mg (20.4 mmol Na+ ), potassium 123 mg (3.1 mmol
K+ ), and citric acid - anhydrous 800 mg,orange flavour and sodium saccharin. Each sachet has a calorific value of
2.5kcals.DOSE:for Hypophosphatemia: ▶ By Mouth: Neonate: 1 mmol/kg daily in
1–2 divided doses, dose can be taken as a supplement in breast milk—caution advised as solubility in breast milk is
limited to 1.2 mmol in 100mL if calcium also added,▶ Child 1 month–4 years: 2–3 mmol/kg daily in 2–4 divided
doses, dose to be adjusted as necessary, dose can be taken as a supplement in breast milk—caution advised as
solubility in breast milk is limited to 1.2 mmol in 100mL if calcium also added. Ref:Neofax&BNFC-2016-17

80 Phosphorus(P)&Potassium(K):(Inj:Potphos 15ml,Each ml contains, Phosphorus(P)93mg,Potassium(K)

170mg/ml)P=3mmol,K=4.25mmol/1ml; INDICATIONS &DOSE: Hypophosphataemia | Hypophosphataemic rickets |
Osteomalacia: BY IV INFUSION:▶ Neonate: 1 mmol/kg daily of Phosphorus, dose to be adjusted as necessary. ▶
Child 1 month–1 year: 0.7 mmol/kg daily of Phosphorus, dose to be adjusted as necessary. Ref:BNFC-
2016-17
81 Phenytoin:vial:2ml(100mg/2ml), DOSE: Loading dose: 15-20mg/kg, Maintenance Dose:Commence 12 hours
after loading dose.<37 weeks ≤14days 2mg/kg/dose 12 hourly, >14days 5mg/kg/dose 12 hourly;≥37weeks ≤14 days
4mg/kg/dose 12 hrly, >14 days 5mg/kg/dose 8 hourly.PREPARATION:IV: Withdraw required the dose.Dilute 1 part
to 10 with NS only.Infusion must be completed within one hour of preparation. ADMINISTRATION: IV Infusion:
Over30-60 mins. Flush line with NS,before &after administration.

82 Piperacillin 2g& Tazobactam 0.25g,Dose and Administration: By I.V Infusion:Neonate: 100mg/kg every 8
hours.Dose expressed as piperacillin component.
CGA Postnatal Age Dose Frequency
<30 weeks ≤28 days 100mg/kg/dose 12 hourly
>28 days 100mg/kg/dose 8 hourly
30-36 weeks ≤14 days 100mg/kg/dose 12 hourly
>14 days 100mg/kg/dose 8 hourly
>36 weeks ≤7 days 100mg/kg/dose 12 hourly
>7 days 100mg/kg/dose 8 hourly
Preparation:Available as powder for injection 2.25gm,Add 9mL of Water for Injections to a 2g vial =
100mg/mL(make up the total 10ml volume). take required dose make final conc of 10 to 40 mg/mL with
D5W.(piperacillin component). Administration:Infuse IV over at least 30 minutes.
83 Potassium Chloride (KCL)10ml vial(Ampoule: Potassium chloride 1.5g/10mL
Contains: 2mmol of Potassium per 1mL,Oral Solution:Syp:200ml;1.5gm/15ml. 20mmol/15mL(1mmol/0.75mL);Dose
:Oral:Initial oral replacement therapy: 0.5 to 1 mEq/kg per day divided and administered with feedings (small, more
frequent aliquots preferred).Acute treatment of symptomatic hypokalemia: IV:Begin with 0.5 to 1 mEq/kg IV over 1
hour, then reassess. DILUTION:Solution must be diluted to 1mmol/25ml if given via a peripheral line, or
1mmol/12.5ml via central line. PREPARATION:IV: Infusion:Withdraw 1mL/kg (2mmol/kg) of potassium chloride,
Dilute to 25mL with appropriate diluent.Compatible fluids: 5%,10% glucose/ NS, ADMINISTRATION:IV: Infusion Run
the infusion at the rate of 1mL per hour (0.08mmol/kg/hour)Max infusion rate:0.2mmol/kg/hr,Oral:Give after feeds.
Dilute before administration with milk or water.Terminal Injection Site Incompatibility:
Amphotericin B, diazepam, and phenytoin.Ref:Neofax

84 Prednisolone: Available formulations:Tab: Omnacortil 5mg,10mg; Syp:Omnacortil 60ml (5mg/5ml) Dose:

Oral: 0.5-2 mg/kg/day divided every 12-24 hrs. Ref
by:Neonatal Dosage and Practical Guidelines Handbook 2n d Edition

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 85 Probiotics- bifidobacterium breve M-16V (Rescunate Sachet/granules)
Dose: Feeds: <50ml/kg/day; One sachet-(1billion CFU)+2.5ml EBM Once daily(OD).
Feeds: >50ml/kg/day; One sachet-(1billion CFU)+2.5ml EBM Twice daily(BD).

86 Propranolol:Hypertension and Tachyarrhythmias: Starting oral dose: 0.25 mg/kg per dose every 6 hours.max 3.5
mg/kg/dose every 6 hours. Starting IV dose: 0.01 mg/kg every 6 hours over 10 minutes.max: 0.15mg/kg/Dose every
6 hours. Effective dosage requirements will vary significantly.Infantile Hemangiomas:Usual maintenance doses 2 to
3mg/kg/day orally in 3divided doses. Therapy should continue until full involution of the lesion has occurred or until
1 year of age. Recurrences have been reported with early discontinuation of therapy. Tapering periods have ranged
from 2weeks to 1 month. Administration For infants receiving propranolol, regular, frequent food intake (every 3 to
4hours) is an important consideration with regards to risks for hypoglycemia.

87 Prostaglandin E1,1ml vial(500mcg/ml)(Alprostadil), Dose and Administration: (PDA): 0.05-0.1 mcg/kg/min ;

Maintenance dose: 0.01mcg/kg /min,Preparation: Mix 1 ampule (500 mcg) in 49 mL of D5W/NS final concentration
of 10 mcg/mL. Infuse at a rate of 0.6 mL/kg per hour to provide a dose of 0.1mcg/kg per minute.

88 Pyridoxine Tab:40mg,vial:100mg/2mL with combination(Vit-B6), Pyridoxine-Dependent Seizures:Initial

diagnostic Dose: 50 to 100mg IV push,or IM. Maintenance dose: 50-100mg orally every 24 hours. High doses may
be required during periods of intercurrent illness. Fitting: 10-15mg/kg daily IV or oral.Sideroblastic Anaemia:2-
8mg/kg (max 400mg) daily IV or oral.Preparation:Compatible Fluids,D5%,NS, ADMINISTRATION: Intravenous:Over 3
– 5 minutes,May use injectable form orally; mix in simple syrup if desired.

89 Ranitidine hcl,Oral: Syp:Rantac 100ml(75mg/5ml),Inj:50mg/2ml, Dose:Treatment:By mouth: Neonate: 2-

3mg/kg every 8 hours.Infant 1–6 months: Start at 1mg/kg every 8 hours. May be increased to 3mg/kg every
8 hours.IV administration: Neonate: 0.5mg/kg given slowly IV twice a day will usually keep the gastric pH >4 in
babies <32 weeks’ gestation in the first week of life.Term babies may need 1-1.5mg/kg every 6–8
hours. administration:take 1ml (25mg) from this ampoule and dilute to 50ml with 5% glucose to get a preparation
containing 500 mcg/ml.To give a continuous infusion of 50mcg/kg/hour(0.1ml/kg/hr).
90 Ribavirin:1) Bronchiolitis: BY INHALATION OF AEROSOL, OR BY INHALATION OF NEBULISED
SOLUTION: Child 1–23 months: Inhale a solution containing 20 mg/mL for 12–18 hours for at least 3 days, maximum
of 7 days, to be administered via small particle aerosol generator. 2)Life-
threatening RSV, parainfluenza virus, and adenovirus infection in immunocompromised
children(administered on expert advice)
▶ BY IV INFUSION: Child: 33 mg/kg for 1 dose, to be administered over 15 minutes, then 16 mg/kg every 6 hours for
4 days,then 8 mg/kg every 8 hours for 3 days. Chronic
hepatitis C (in combination with interferon alfa or peginterferon alfa) in previously untreated children without
liver decompensation
BY MOUTH: Child 3–17 years: 15 mg/kg daily in 2 divided doses
91 Rocuronium 5ml(vial:50mg/5ml); Dose: 0.3 to 0.6 mg/kg per dose IV push over 5 to 10 seconds.
Preparation:for IV is available in 5mL multiple-dose vials containing 10mg/mL.Each mL contains 10mg Rocuronium
bromide and 2 mg sodium acetate,To prepare a mg/mL solution, dilute 1 mL of the 10mg/mL solution up to a final
volume of 10 mL with NS. Dilution stable for 24 hours. ADMINISTRATION:IV push over 5 to 10 seconds. Do not give
IM. Must be accompanied by adequate analgesia and/or sedation.

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92 Salbutamol(oral:100ml(2mg/5ml),Neb:Resp:2.5mg/2.5ml. DOSE: Bronchodilator dose:Using aerosol via a
spacer device (eg Aerochamber®),200 microgram (2 puffs)6 hourly Nebulisation
only: Starting dose: 150microgram (0.03mL) /kg/dose 4-6 hourly Max dose: 500microgram (0.1mL) /kg/dose 4-6
hrly. Neonatal hyperkalaemia.IV: 4 microgram/kg/ dose. Dose may be repeated once after a minimum of two
hours.Nebulisation: 400mcg /kg/dose 2 hrly. PREPARATION: Nebulisation Diluent: Sodium Chloride 0.9%,Dilute to
3mL (or an appropriate volume).ADMINISTRATION: Nebulisation:Aerosol via a spacer device,Shake canister well
before use Nebulised via endotracheal tube,The expiratory block of ventilators should be changed on a weekly basis
when nebulised drugs are used.
93 Sildenafil citrate(Tab:25 mg,50mg,inj:10mg/12.5ml); Dose and Administration: Pulmonary hypertension:
IV:Administer a loading dose of 0.4 mg/kg over 3 hours, followed by a continuous infusion of 1.6mg/kg/day (0.067
mg/kg/hour) .Oral: 0.5 to 3mg/kg/dose every 6 to 12 hours. Preparation:single-use vial containing 10 mg (12.5 mL)
of sildenafil, equivalent to 0.8mg/mL.Each mL of solution also contains 50.5 mg dextrose and water for injection.

94 Tab:SIROLIMUS-1mg; Prophylaxis of Renal Transplant Rejection:Dose: Oral: Loading dose: <40 kg: 3 mg/m².
Maintenance:1 mg/m² /day, if <40 kg on day 2 and thereafter; obtain trough levels between 5-7 days.Dose
adjustments: Dose should be adjusted to maintain trough concentrations within desired range based on clinical
state and concomitant therapy; further dose adjustment should not be done sooner than 7-14 days following a dose
adjustment. Oral Administration:Administer sirolimus dosage at approximately the same time each day. To
minimize variations in bioavailability, administer consistently with or without food.In renal transplant patients,
administer 4 hours after cyclosporine oral solution or capsules.

95 Tab:Spironolactone 25mg ,Dose and Administration: Oral: Treatment of CHF and BPD: 0.75 to 1.5
mg/kg/dose 12 hourly oral(PO).
96 Sodium bicarbonate:10ml (7.5% w/v,10ml=8.9meq,1ml=0.89meq), inj,
Tab:500mg(5.95meq),300mg(3.57meq); Dosage based on base deficit: HCO3 needed (mEq) = HCO3 deficit (mEq/L)
x (0.3 x body wt [kg]),Administer half of calculated dose, then assess need for remainder.Usual dosage: 1 to 2
mEq/kg IV over at least 30 minutes
1) Emergency neonatal resuscitation: Dose: 1-2mmol/kg by slow IV push.
2) Metabolic acidosis: A) Documented metabolic acidosis during prolonged resuscitation after establishment of
effective ventilation: Administer half calculated dose then assess need for remainder. Administered by slow IV
infusion over 30 mins.
B) Bicarbonate deficit caused by renal or gastrointestinal losses: Slow correction orally. Sodium bicarbonate dose
(ml) = base deficit x 0.6 x weight (kg).
3)Persistent pulmonary hypertension of the newborn. 0.25-0.50 mmol/kg/hour. Continuous IV infusion.
Administration: Slow IV Infusion: Dilute prior to use 1:1 with sterile water for injection. Filter prior to administration
through a 5 micron filter. Administer by slow IV infusion over 30 minutes using a syringe pump. Incompatible with
calcium. Compatible with NS, D5W, D10W. Flush with NS before and after administration of sodium bicarbonate.
Ref by: www.adhb.govt.nz/newborn/DrugProtocols,Neopox
97 Sodium polystyrene sulfonate,(Kayexalate 454gms) (Cation - Exchange Resin, Jar:454gms.): Neonates:
Dose and Administration: Rectal:0.5 -1gm /kg every 20 minutes PRN, have infant retain dose for 15-20 minutes.
Rectal Preparation:Mix each gram in 4 ml of water/glycerine. Do NOT heat mixture prior to administration. May
change exchange properties. Administer via an 8 Fr, feeding tube,Insert 2.5-3.5cm into rectum.Elevate hips during
administration. May need to hold buttocks together so body retains enema for approximately 20 minutes.Special
Considerations:1)Sodium content 100 mg/gm.2)Administration with sorbitol facilitates passage through GI tract,
prevents constipation.3)For severe hyperkalaemia (>7.5 mmol/L) consider emergency therapy such as IV glucose
and insulin or IV sodium bicarbonate. 4)Monitor serum electrolytes for hypernatraemia,
hypokalaemia,hypocalcaemia.
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98 Surfactants:(BOVINE) – BERACTANT (SURVANTA)Vial:4mL,8ml,Each ml contains, Phospholipids 25mg; DOSE:
4mL/kg/dose Up to four doses may be administered, at 6 hourly intervals.ADMINISTRATION: For intratracheal
administration only.Survanta is administered via a 5fg end hole catheter shortened to protrude just beyond the end
of the ETT, above the carina. Survanta should NOT be instilled into a main stem bronchus.SURFACTANT (PORCINE) –
PORACTANT ALFA(CUROSURF):Vials: 120mg/1.5 mL, 240mg/3mL, DOSE: Rescue treatment Initial dose: 2.5mL/kg
(200mg/kg), Subsequent doses: 1.25mL/kg (100mg/kg). Up to 2 subsequent doses at 12 hourly intervals may be
administered. Max total dose: 400mg/kg. Prophylaxis:Initial dose: 1.25mL-2.5mL/kg 100mg – 200mg/kg)
administered within 15 minutes of birth.Subsequent doses of 1.25mL (100mg) /kg may be given 6-12 hours after the
first dose and then 12 hours later in babies who remain ventilator dependent. Max total dose: 300-
400mg/kg.ADMINISTRATION: For intratracheal administration only.Poractant is administered via a 5fg end hole
catheter shortened to protrude just beyond the end of the ETT, above the carina. Poractant should NOT be instilled
into a main stem bronchus.

Ticarcillin with clavulanic acid:

Infections due to Pseudomonas and Proteus spp.
▶ BY INTRAVENOUS INFUSION: Preterm neonate < 2 kg): 80 mg/kg every 12 hours.
▶ Preterm neonate (2 kg &above): 80 mg/kg every 8 hours; increased if necessary to 80 mg/kg every 6 hours,
increased frequency used for more severe infections.
▶ Neonate: 80 mg/kg every 8 hours; increased if necessary to 80 mg/kg every 6 hours, increased frequency used for
more severe infections.
99 Tigecyclin (50mg dry powder,vial ),Dose and Administration: 2mg/kg iv over 1 hr stat then 1 mg/kg 12 hrly iv
over 30 mints. Preparation: Each vial of TYGACIL should be reconstituted with 5.3 mL of NS/5DW to achieve a
concentration of 10 mg/mL of tigecycline. (Note: Each vial contains a 6% overage. Thus, 5 mL of reconstituted
solution is equivalent to 50 mg of the drug.) The vial should be gently swirled until the drug dissolves. Withdraw 5
mL of the reconstituted solution from the vial and further dilute to 1mg/ml concentration with NS/5DW. solution
should be yellow to orange in color; Administration: iv over 30 to 60 minutes.flushed before and after infusion
with NS/5DW Injection.
100 Tobramycin 2ml(inj:80mg/2ml)Dose and Administration, IV/IM: PMA(weeks) Postnatal(days)
Dose(mg/kg) Interval(hours)
≤29* 0 to 7 5 48
8 to 28 4 36
≥29 4 24
30 to 34 0-7 4.5 36
≥8 4 24
≥35 ALL 4 24
Nebulisation: 20mg every 12 hours. Preparation:Take 2ml vial & dilute to 8ml NS (10mg/ml).Nebulisation: Dilute
dose to 2mL. (or an appropriate volume).Administration:IV infusion by syringe pump over 30 minutes.

101 Topiramate(Tab: 25mg,50mg), Dose and Administration: Loading 10mg/kg folled by maintenance dose 5-
8mg/kg/day; Updated dosage: Dose: Begin at 1 to 3 mg/kg/day as a single (nightly) dose for the first week. The
dosage should then be increased by 1 to 3 mg/kg/day at weekly or longer intervals to the recommended total daily
dose of 5 to 10mg/kg/day in 1–2 divided doses.
Daily doses over 10 mg/kg in infants over 1 month age have been studied and were generally well
tolerated. The daily dosage should be given as two divided doses.
Ref by:Neonatal Medicines Formulary Consensus Group

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102 Triclofos Sodium (500 mg/5ml syp:Pedicloryl),
Dose and Administration: Child: 50mg/kg/dose (0.5ml/kg/dose-STAT)
103 Ursodeoxycholic acid (Tab:150mg,300mg ), Dose and Administration:10-15mg/kg 12 hr oral.
104 Valganciclovir 450mg (Tab:450mg)
Treatment of infants with symptomatic congenital CMV infections Dose: 16mg/kg per dose orally every 12hours.
Treat for a minimum of 6 weeks; longer-term treatment may be appropriate. Ref by:Neofox

105 Vancomycin 500mg vial, single dose use only., Dose:

Gestational Age Postnatal Age Dose Frequency
< 30 weeks 0-7 days 10mg/kg/dose 12 hourly
>7 days 10mg/kg/dose 8 hourly
30-37 weeks 0-7 days 15mg/kg/dose 12 hourly
>7 days 15mg/kg/dose 8 hourly
37-44 weeks All ages 25mg/kg/dose 12hourly.
PREPARATION:use the following process to prepare a 5mg/mL solution.
Step 1 – Reconstitution:Diluent: (SWI)Water for Injections,Add 9.8mL of diluent to a 500mg vial.Step 2 -
Dilution,Withdraw 1mL (50mg/mL) of this solution.Further dilute to 10mL with NS/5DWS solution, 50mg/10mL, or
5mg/mL. ADMINISTRATION:IV infusion by syringe pump over 1 to 2 hours.STORE:Cool dry place.

106 Inj:Vecuronium(4mg/2ml,10mg/5ml): Indication: Muscle paralysis for intubation or ventilation

Dosage: 0.1mg/kg STAT-Dose followed by 0.03 - 0.15mg/kg /hr infusion ADMINISTRATION IV as a push or as an
infusion. Preparation: To reconstitute add 2 mL Water for Injection to the ampoule (= 2 mg/mL) For STAT dose no
further dilution; For infusion add 5mg/kg to make up to 50mL with normal saline(NS)or 5% glucose (5%D); 1 mL/hr =
0.1mg/kg/hr.COMPATIBILITY Fluids & Solutions: NS, D5W, DNS, Hartmann’s, Ringers,
Incompatibility: Diazepam, frusemide, ibuprofen, phenobarbitone, phenytoin, sodium bicarbonate ADVERSE
EFFECTS Respiratory depression, apnoea, skeletal muscle weakness, acidosis, hypotension, electrolyte imbalance
ANTIDOTE:Effects can be reversed by neostigmine and atropine. STORAGE: Store at room temp and protect from
light.
107 Vitamin K1 (Phytomenadione)1mg/0.5mL, DOSE: Prophylaxis: IM, IV, UA, UV:weight:<1500g: 0.5mg (0.05mL)
as a single dose,>1500g: 1mg (0.1mL) as a single dose,Oral: 3 doses to be administered Day 1: 2 mg (0.2mL),Day 2: If
first dose not retained, repeat dose.Day3-5: 2 mg (0.2mL),Week 4 : 2mg (0.2mL) Neonatal biliary atresia and liver
disease:1mg daily.PREPARATION: IV: May be diluted to 0.5mL if required for ease of administration, Diluent :
Glucose 5, 10%, Glucose / saline,Sodium chloride 0.9%. ADMINISTRATION: IV : Give slowly over5-10
minutes,Umbilical arterial or venous injection.
108 Vitamin D(Cholecalciferol),Drops:1ml=400IU,Sachet=60,000 IU; Dose: Supplementation: 400 units per day orally.
Treatment of vitamin D deficiency:1000 units per day orally.Recent data indicate that administration of high doses
of vitamin D (4000 to 6400 units daily) to breastfeeding mothers is capable of raising 25(OH)-D levels in the infant to
levels similar to those seen with infant supplementation without causing hypervitaminosis D in the mother.

109 Vitamin-A,B,C,D&E complex (Multivitamin Products),Inj:MVI 10ml, Drops:Zincovit,Visneral-Z, Zincovit Drops

contains Each mL vitamin A 1000 IU, vitamin D3 200 IU, vitamin C 40 mg, vitamin B3 8 mg, zinc 3 mg, vitamin E 2.5
IU, vitamin B1 0.8 mg , vitamin B2 0.6 mg, vitamin B6 0.5 mg, Lysine hydrochloride 10 mg , nicotinamide 8 mg, D-
panthenol 1 mg, Biotin 20 mcg, carbohydrates 0.595 g, fat 0.003 g, choline 25 mcg, polyunsaturated fatty acids 1.98
mg,monounsaturated fatty acid 0.6 mg, saturated fatty acids 0.28 mg and flaxseed oil 3mg. DOSE:1 mL every 24
hours.

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110 VITCOFOL 15ml oral drops: Folic acid(vit B9) 5mcg, Vit- B12 200mcg, Nicotinamide (vit-B3) 20mg/1mL. May be taken
with or without food.Child upto 1 yr: 0.5ml daily; >1 yr: 1 ml daily or as reqd
111 Voriconazole:(Tab:50mg,200mg); BY MOUTH: Child 2–11 years: Treatment should be initiated with
intravenous regimen, and oral regimen should be considered only after there is a significant clinical
improvement; maintenance 9 mg/kg every 12 hours,adjusted in steps of 1mg/kg and increased if necessary up to
350 mg every 12 hours, then adjusted in steps of 50 mg as required By Intra venous
Infusion: Child 2–11 years: Initially 9 mg/kg every 12 hours for 2 doses,then 8mg/kg every 12 hours; adjusted in
steps of 1 mg/kg as required; for max. 6 months

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