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Journal of Pediatric Hematology/Oncology. 26(10):619-625, OCTOBER 2004

DOI: 10.1097/01.mph.0000140651.65591.b8,  PMID: 15454831
Issn Print: 1077-4114
Publication Date: October 2004

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Oral Glutamine Supplementation

Decreases Resting Energy Expenditure in
Children and Adolescents With Sickle Cell
Anemia
Ruth Williams;Stacie Olivi;Chin-Shang Li;Michael Storm;Lola Cremer;Paul Mackert;Winfred Wang;

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Abstract
Objectives:
To determine the effects of orally administered glutamine on the resting energy expenditure (REE)
and nutritional status of children and adolescents with sickle cell anemia.
Methods:
Twenty-seven children and adolescents (13 boys, 14 girls), 5.2 to 17.9 years old (median 11.0 years),
received orally administered glutamine (600 mg/kg per day) for 24 weeks. Measures of REE and
other nutritional parameters were compared at baseline and 24 weeks.
Results:
After 24 weeks, the patients’ median REE (kcal/d) decreased by 6% (P = 0.053) as indicated by the
Harris Benedict equations and by 5% (P = 0.049) as indicated by the modified equations. Patients
with less than 90% ideal body weight had even greater declines in REE after 24 weeks (P < 0.03
and 0.02, respectively). Improvements in nutrition parameters and in two amino acids in the
plasma were observed.
Conclusions:
After 24 weeks of orally administered glutamine, children and adolescents with sickle cell anemia
had a decrease in REE and improvement in nutritional parameters. Those who were underweight
had a greater decrease in REE than those of normal body weight. Lowering REE may be an
effective way to improve the growth of these children and adolescents.

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