Xyloglucan for the Treatment of Acute Gastroenteritis in Children: Results of a

Randomized, Controlled, Clinical Trial

Abstract
Background: Xyloglucan, a film-forming agent, improves intestinal mucosa resistance to pathologic
damage. The efficacy, safety, and time of onset of the antidiarrheal effect of xyloglucan were assessed
in children with acute gastroenteritis receiving oral rehydration solution (ORS). Methods. This
randomized, controlled, open-label, parallel-group, multicenter, clinical trial included children (3
months–12 years) with acute gastroenteritis of infectious origin. Children were randomized to
xyloglucan and ORS, or ORS only, for 5 days. Diarrheal symptoms, including stool
number/characteristics, and safety were assessed at baseline and after 2 and 5 days and by fulfillment
of a parent diary card. Results. Thirty-six patients (58.33% girls) were included (/group). Patients
receiving xyloglucan and ORS had better symptom evolution than ORS-only recipients, with a faster
onset of action. At 6 hours, xyloglucan produced a significantly greater decrease in the number of
type 7 stools (0.11 versus 0.44; ). At days 3 and 5, xyloglucan also produced a significantly greater
reduction in types 6 and 7 stools compared with ORS alone. Xyloglucan plus ORS was safe and well
tolerated.
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Condratovici, C.P., Bacarea, V., & Piqué, N. (27, March 2016). Xyloglucan for the Treatment of
Acute Gastroenteritis in Children: Results of a Randomized, Controlled, Clinical Trial.
Gastroenterology Research and Practice, 2016(6874207).
http://dx.doi.org/10.1155/2016/6874207
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An Approach to the Child with Acute Glomerulonephritis

Abstract
Acute glomerulonephritis (AGN) is a common condition in childhood. Many children with AGN
can be managed in the primary care setting. The diagnosis is usually made on the basis of urinary
findings, especially the presence of red blood cell casts. One of the most important initial
investigations is determining the complement C3 level; hypocomplementemia is most characteristic
of post streptococcal AGN, while normocomplementemia is most often seen with IgA nephropathy.
Children whose AGN is accompanied by significant hypertension or renal insufficiency should be
assessed by a specialist immediately. The presence of serious extrarenal signs or symptoms also merits
urgent referral. Otherwise, serial follow up in the primary care office is appropriate.
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Weltch, T.R. (2011, October 13). An Approach to the Child with Acute Glomerulonephritis.
International Journal of Pediatric, 2012(426192). http://dx.doi.org/10.1155/2012/426192