!

(https://www.lauric-
arginate.com/)
Lauric Arginate is the term that has been accepted by the Food and Drug Administration
(FDA) for labelling purposes of Ethyl lauroyl arginate HCl. Other names commonly used to
refer to this substance are LAE ® and Lauroyl arginine ethyl ester HCl.

Ethyl lauroyl arginate HCl is a synthetically produced cationic substance manufactured in

LAMIRSA GROUP premises, according to processes patented by the company. The main
particularity of Ethyl lauroyl arginate is that its building blocks are naturally occurring
substances: L-arginine, ethanol and lauric acid. Once Ethyl lauroyl arginate HCl is ingested by
consumers, it is easily hydrolysed within a few minutes in the human body into natural
compounds commonly found in the diet. This property is not shared by the other food
preservatives currently found in the marketplace such as sorbates, benzoates, sulphites,
nitrites and nitrates.
 Effective against Gram positive and Gram negative
bacteria, yeasts and moulds

Ethyl lauroyl arginate HCl is effective as a preservative against bacteria, yeast

and moulds in a wide range of food and cosmetic products because it is able to
disrupt the integrity of the cell membranes of these microorganisms (J. Appl. Microbiol.,
2004, 96 (5) 903-912). EQcacy shown through out MIC’s (Minimum Inhibitory
2004
Concentration) is high. For instance, against Gram positive and Gram negative bacteria
MIC’s are between 8 and 64 μg/ml as an average, and against yeast and mould are between
16 and 128 μg/ml. In spite of those MIC values, the doses of application of LAE® in the Xnal
food and cosmetic products are usually higher. This is due to the differences in composition,
conditions and requirements that those products have compared to the one of an in vitro
test.
 Investigations have proved that Ethyl lauroyl arginate HCl causes the inactivation or
neutralisation of the endotoxins released by Gram negative bacteria, such as Escherichia
coli, which might mitigate the damage caused by endotoxins in animals and human beings.

Safe and effective products for the treatment of viral infections are constantly needed. In
this sense, VEDEQSA commissioned several investigations to study the eLcacy
of Ethyl lauroyl arginate HCl against certain viruses. The results of these
investigations proved a strong antiviral activity against viruses of Vaccinia, Herpes simplex
and bovine parain]uenzae virus types.

VEDEQSA highlights the fact that Ethyl lauroyl arginate HCl has applications in cosmetics
as an active ingredient as well as a preservative.

The following tables show the MIC’s values of LAE ® against different types of
microorganisms, also pathogens, which gives an insight into LAE ® wide range of activity
and great effectiveness. The results were obtained by Dr. Manresa, from the Facultat de
Farmàcia of Universitat de Barcelona:

LAE ®
GRAM POSITIVE BACTERIA
( µ g/ml)

Alicyclobacillus acidiphilus DSMZ 14558 8

Arthrobacter oxydans ATCC 8010 64

Bacillus cereus var mycoide ATCC 11778 32

Bacillus subtilis ATCC 6633 16

Clostridium botulinum ATCC 19397 64

Clostridium estertheticum ATCC 51377 32

Clostridium perfringens ATCC 77454 16

Clostridium perfringens ATCC 12917 16

Lactobacillus curvatus ATCC 25601 16

Lactobacillus delbrueckkii ssp lactis ATCC 10705 16

Lactobacillus paracasei ATCC 25302 16

Lactobacillus plantarum ATCC 8014 16

Listeria monocytogenes B4/97 [1] 8

Listeria monocytogenes ATCC 15313 32

Leuconostoc mesenteroides ATCC 19255 32

Microccocus luteus ATCC 9631 128

Mycobacterium phlei ATCC 41423 2

Staphylococcus aureus ATCC 6538 8

LAE ®
GRAM NEGATIVE BACTERIA
( µ g/ml)

Alcaligenes faecalis ATCC 8750 64

Bordetella bronchiseptica ATCC 4617 128

Campylobacter jejuni ATCC 29428 8

Citrobacter freundii ATCC 22636 64

Enterobacter aerogenes ATCC 13048 32

Enterobacter faecalis ATCC 27285 4

Enterobacter sakazakii ATCC 29544 32

Escherichia coli 0157H7 ATCC 35150 32

Escherichia coli ATCC 8739 32

Klebsiella pneumoniae var pneumoniae ATCC 4352 32

Proteus mirabilis CECT 170 32

Pseudomonas aeruginosa ATCC 9027 32

Pseudomonas ]uorescens ATCC 13430 32

Salmonella choleraesuis ATCC 13076 8

Salmonella typhimurium ATCC 14028 32

Shigella dysentariae ATCC 13313 8

Serratia marcescens ATCC 10759 32

Yersinia enterocolitica ATCC 27729 16

Vibrio parahaemolyticus ATCC 17802 128

LAE ®
YEASTS
( µ g/ml)

Candida albicans ATCC 10231 16

Rhodotorula rubra CECT 1158

 16

Saccharomyces cerevisiae ATCC 9763 32

LAE ®
MOULDS
( µ g/ml)

Aspergillus niger ATCC 14604 32

Aureobasidium pullulans ATCC 9348 16

Glicocladium virens ATCC 4645 32

Chaetomium globosum ATCC 6205 16

Penicillium chrysogenum ATCC 9480 128

Penicillium funiculosum CECT 2914 16

[1] Isolated from polluted meat by Microbiology Unit, Facultat de Farmàcia, Universitat de
Barcelona.

CONTACTO

VEDEQSA
Géminis, 4
Pol. Ind. Can Parellada
08228 Terrassa – Barcelona,Spain
Tel: (+34) 937 315 094
comercial@vedeqsa.com

CONTACT
VEDEQSA INC
201, North Forest Ave., Suite #220
Independence (MO) 64050, USA
Tel: (+1) 816 336 9263
info@vedeqsainc.com

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