ChemOffice v17.

1
Release Notes

Last Updated: January 4, 2018

Table of Contents

1 GENERAL DESCRIPTION...................................................................................................................................3
2 DISTRIBUTION LIMITATIONS.............................................................................................................................3
3 RELEASE QUALIFICATION ................................................................................................................................4
3.1 SCOPE OF TESTING .........................................................................................................................................4
3.2 TESTING ENVIRONMENT...................................................................................................................................5
4 INSTALLATION INSTRUCTIONS ........................................................................................................................5
4.1 PREREQUISITES AND SYSTEM REQUIREMENTS ...................................................................................................5
4.2 RELEASE INSTALLATION ...................................................................................................................................5
4.3 MANIFEST ......................................................................................................................................................6
5 KNOWN ISSUES, LIMITATIONS AND WORKAROUNDS .................................................................................12
6 TECHNICAL SUPPORT .....................................................................................................................................14
ChemOffice v17.1 Release Notes

1 General Description
ChemOffice17.1 is the latest release of the ChemOffice suite of productivity tools for chemists and biologists.
ChemOffice helps scientists efficiently capture and share their work, visualize and gain a deeper understanding of their
results, and correlate biological activity and other properties with chemical structures.

The release is qualified against the following:

• Windows 7 (32 bit and 64 bit), Windows 8.1 (64 bit) and Windows 10 (64 bit) including Creators Update
o On Windows 10, IE 11 is supported, no support for Microsoft Edge browser.
• Microsoft Office 2013, Microsoft Office 2016 and Microsoft Office 365
• Mac OS X 10.12 (Sierra) and Mac OS X 10.13 (High Sierra) – (for ChemDraw only)
• Adobe Acrobat 11

Highlights to this release:

• ChemDraw add-ins enable third parties to extend the capability of ChemDraw by integrating features
easily and quickly using the latest web based technologies. The add-ins are implemented using
Javascript/HTML for ease of integration and portability. The ChemDraw add-in platform provides access
to a ChemDraw JavaScript API which enable the add-ins to access the various features of ChemDraw.
For more information, see API reference guide.
• ChemDraw and ChemDrawJS support copy and paste from ChemDrawJS to ChemDraw using the
simple copy/paste paradigm (Ctrl+C/Ctrl+V on windows, Command+C/Command+V on Mac). Selecting
a structure in ChemDrawJS and copying it using the platform specific keyboard shortcut will paste into
ChemDraw using the platform specific keyboard shortcut.
You may copy from ChemDraw and paste directly into ChemDrawJS when you have the clipboard
extension installed. If the extension is not installed, you should use Edit>Copy As>CDXML Text
(Ctrl+D/Command+D) to place the CDXML data on the clipboard in text format that can be accessed by
the browser without needing the extension.
• ChemDraw now supports the naming of enhanced stereo centers. Names including ‘AND’ and ‘OR’
enhanced stereo centers and absolute stereo centers (in any combination) are supported.
• A new option has been added ("Hide Absolute Stereoflags."). When checked it will hide any "abs"
flags displayed on the stereo centers and the "Abs" stereoflag. If unchecked they would be displayed
again. It is therefore a display only preference. As such it applies to all file formats as the preference
setting does not alter the existing enhanced stereochemistry of the mode.
• A new option has been added ("Suppress Setting Default Abs Enhanced Stereochemistry for MDL
Format Files."). When enabled, this option allows you to suppress the writing of “Abs” stereoflag on
molecules with Enhanced Stereochemistry, when writing to MDL format files.
• ChemDraw now supports a new atom numbering scheme, where the numbers are derived from their
explicit or implicit values in the IUPAC name.
• ChemDraw will now detect meso-compounds (defined as a stereoisomer with an identical or
superimposable mirror image) and not place chiral flags on the atoms.

2 Distribution Limitations
N/A

© Copyright 1998-2018 PerkinElmer Informatics, Inc. All Rights Reserved. 3 of 14

ChemOffice v17.1 Release Notes

3 Release Qualification
3.1 Scope of Testing
For the ChemOffice17.1 release, the following testing conditions have been set and executed:
• Installations:
o Default mode
o Custom mode
o Side-by-Side compatibility modes

• Enhanced Functionality:
o The Flexera activation system is now used

• Third Party Compatibility:

o Operating Systems: Windows 10 (64 bit) including Creators Update, Windows 8.1 (64 bit), Windows 7 (32
bit and 64 bit), Mac OS X 10.13.1 (High Sierra), Mac OS X 10.12.5 (Sierra)
Note: Only ChemDraw is compatible with Mac systems, not ChemOffice Professional 17.1.
o MS Office: Office 365, 2016 (Mac & Windows), 2013 with SP1
o Browsers for ActiveX Controls: Internet Explorer 11 and 10
o Calculation Engines for Chem3D: Gaussian 09 Revision-D.01, MOPAC2016, Conflex7.2B, Autodock
4.2.6, MGL Tools 1.5.4 (for Autodock), msroll.exe (Archaic), and GAMESS 2013.
Note: Chem3D supports the 64-bit version of GAMESS only.
o Python for ChemScript: 3.2 and 2.5
o Visual C# for ChemScript: 2010
o Visual Studio 2010

• Regression Testing:
o Targeted regression testing of ChemOffice Professional package on Windows 10 64 bit and ChemDraw
Professional package on Mac OS X 10.13.1 (High Sierra).
o Verification of issue fixes and regression testing of related features.

• Backward & Forward Compatibility:

o Testing with files created using current and past versions of ChemOffice applications.

• Japanese Localization:
o Limited testing on Windows 10 (64-bit), High Sierra and Sierra systems.

• Release Candidate Qualification Testing:

o Digital signature verifications.
o Sanity/Smoke test executions with all packages in mixed environments.
o SciStore download tests.
o Qualification of the download executables.

© Copyright 1998-2018 PerkinElmer Informatics, Inc. All Rights Reserved. 4 of 14

ChemOffice v17.1 Release Notes

3.2 Testing Environment

The following table details the testing environments for ChemOffice v17.1:

Machine Operating Database MSOffice Browser Adobe IIS

Type System Version Version Version

Windows 10
Professional 64-
2016 (32-bit), 2013
Client bit (including N/A IE11 Acrobat 11 N/A
(32-bit) SP1
Creators
Update)

Windows 8.1
2016 (32-bit), 2013
Client Professional 64- N/A IE11 Acrobat 11 N/A
(32-bit) SP1
bit

Windows 7
Client Professional 32- N/A 2016, 2013 SP1 IE10, IE11 Acrobat 11 N/A
bit

Windows 7
2016 (32-bit), 2013
Client Professional 64- N/A IE10, IE11 Acrobat 11 N/A
(32-bit) SP1
bit

Mac OS X 10.13
(High Sierra)
Client N/A 2016 (15.25) Safari 10.0.1 Acrobat 11 N/A
(ChemDraw
only)

Mac OS X
10.12.5 (Sierra)
Client N/A 2016 (15.25) Safari 10.0.1 Acrobat 11 N/A
(ChemDraw
only)

4 Installation Instructions
4.1 Prerequisites and System Requirements
For information about system requirements please refer to the DT-17.1 Hardware Software Guide (part of this release
package).

4.2 Release Installation

Please note the following when installing ChemOffice v17.1:

• For a clean installation, we recommend running the main executable as Administrator.

• The Desktop 17.1 packages can be installed side-by-side with older Desktop packages.

© Copyright 1998-2018 PerkinElmer Informatics, Inc. All Rights Reserved. 5 of 14

ChemOffice v17.1 Release Notes

4.3 Manifest
The Desktop v17.1 release includes the following SKUs and components:

• ChemOfficeProfessional
o * DVD navigation
 autorun.inf
 ChemOfficeProfessional171.cdd
 ChemOfficeProfessional171.exe
 CO.ico
 lua5.1.dll
 lua51.dll
 autorun\dat01\ap1.dat
 autorun\dat01\ap10.dat
 autorun\dat01\ap11.dat
 autorun\dat01\ap12.dat
 autorun\dat01\ap13.dat
 autorun\dat01\ap14.dat
 autorun\dat01\ap15.dat
 autorun\dat01\ap16.dat
 autorun\dat01\ap17.dat
 autorun\dat01\ap18.dat
 autorun\dat01\ap19.dat
 autorun\dat01\ap2.dat
 autorun\dat01\ap20.dat
 autorun\dat01\ap21.dat
 autorun\dat01\ap22.dat
 autorun\dat01\ap23.dat
 autorun\dat01\ap24.dat
 autorun\dat01\ap25.dat
 autorun\dat01\ap26.dat
 autorun\dat01\ap27.dat
 autorun\dat01\ap28.dat
 autorun\dat01\ap29.dat
 autorun\dat01\ap3.dat
 autorun\dat01\ap30.dat
 autorun\dat01\ap31.dat
 autorun\dat01\ap32.dat
 autorun\dat01\ap33.dat
 autorun\dat01\ap34.dat
 autorun\dat01\ap35.dat
 autorun\dat01\ap36.dat
 autorun\dat01\ap37.dat
 autorun\dat01\ap38.dat
 autorun\dat01\ap39.dat
 autorun\dat01\ap4.dat
 autorun\dat01\ap40.dat
 autorun\dat01\ap41.dat
 autorun\dat01\ap42.dat
 autorun\dat01\ap43.dat
 autorun\dat01\ap44.dat
 autorun\dat01\ap45.dat
 autorun\dat01\ap46.dat
 autorun\dat01\ap47.dat
 autorun\dat01\ap48.dat
 autorun\dat01\ap49.dat
 autorun\dat01\ap5.dat
 autorun\dat01\ap50.dat
 autorun\dat01\ap51.dat
 autorun\dat01\ap52.dat

© Copyright 1998-2018 PerkinElmer Informatics, Inc. All Rights Reserved. 6 of 14

ChemOffice v17.1 Release Notes

 autorun\dat01\ap53.dat
 autorun\dat01\ap54.dat
 autorun\dat01\ap55.dat
 autorun\dat01\ap56.dat
 autorun\dat01\ap57.dat
 autorun\dat01\ap58.dat
 autorun\dat01\ap59.dat
 autorun\dat01\ap6.dat
 autorun\dat01\ap60.dat
 autorun\dat01\ap61.dat
 autorun\dat01\ap62.dat
 autorun\dat01\ap63.dat
 autorun\dat01\ap64.dat
 autorun\dat01\ap65.dat
 autorun\dat01\ap66.dat
 autorun\dat01\ap67.dat
 autorun\dat01\ap7.dat
 autorun\dat01\ap8.dat
 autorun\dat01\ap9.dat
 autorun\Icons\3D.ico
 autorun\Icons\CD.ico
 autorun\Icons\CF.ico
 autorun\Icons\CO.ico
 autorun\Icons\CS.ico
 autorun\Icons\EN.ico
 autorun\Icons\FO.ico
 autorun\Icons\IN.ico

o * Installation
 Windows\Install.exe
 Windows\Install.ini
 Windows\MSCOMCTL.OCX
 Windows\QProGIF.ocx
 Windows\RICHTX32.OCX
 Windows\PerkinElmer\Activation\Activate.exe
 Windows\PerkinElmer\Activation\activationhelp.html
 Windows\PerkinElmer\Activation\FlxComm.dll
 Windows\PerkinElmer\Activation\FlxCore.dll
 Windows\PerkinElmer\Activation\concrt140.dll
 Windows\PerkinElmer\Activation\msvcp140.dll
 Windows\PerkinElmer\Activation\vccorlib140.dll
 Windows\PerkinElmer\Activation\vcruntime140.dll
 Windows\PerkinElmer\Activation\FNEactivationhelp.html
 Windows\PerkinElmer\Activation\registerproduct.html
 Windows\PerkinElmer\Activation\registerproductemail.html
 Windows\PerkinElmer\Activation\registerproductfax.html
 Windows\PerkinElmer\Activation\registerredirect.html
 Windows\PerkinElmer\ChemOffice\PerkinElmer_ChemOffice_64-bit_Support_17.1.msi
 Windows\PerkinElmer\ChemOffice\PerkinElmer_ChemOffice_Professional_2017.msi
 Windows\PerkinElmer\ChemScript\PerkinElmer_ChemScript_17.1.msi
 Windows\ThirdParty\Microsoft\VCRedist\vcredist_x64.exe
 Windows\ThirdParty\Microsoft\VCRedist\vcredist_x86.exe
 Windows\ThirdParty\Microsoft\WinInstaller4.5\Windows6.0-KB942288-v2-x64.msu
 Windows\ThirdParty\Microsoft\WinInstaller4.5\Windows6.0-KB942288-v2-x86.msu
 Windows\ThirdParty\Microsoft\WinInstaller4.5\WindowsServer2003-KB942288-v4-x64.exe
 Windows\ThirdParty\Microsoft\WinInstaller4.5\WindowsServer2003-KB942288-v4-x86.exe
 Windows\ThirdParty\Microsoft\WinInstaller4.5\WindowsXP-KB942288-v3-x86.exe
 Windows\ThirdParty\NETInstaller\dotNetFx40_Full_x86_x64.exe
 Windows\ThirdParty\Python\python-3.2.2.msi
 Windows\ThirdParty\PythonExt\pywin32-217.win32-py3.2.exe

© Copyright 1998-2018 PerkinElmer Informatics, Inc. All Rights Reserved. 7 of 14

ChemOffice v17.1 Release Notes

 Windows\_images\progress.gif
o Docs\ChemOffice v17.1 Release Notes.pdf (This document)
o Docs\DT-17.1 Hardware Software Guide.pdf
o Manuals
 Chem3D.pdf
 ChemDraw.pdf
 ChemFinder.pdf
 ChemFinderForOffice.pdf

• ChemDraw Professional (Win/Mac)

o * DVD navigation
 autorun.inf
 CD.ico
 ChemDrawProfessional171.cdd
 ChemDrawProfessional171.exe
 lua5.1.dll
 lua51.dll
 autorun\dat01\ap1.dat
 autorun\dat01\ap10.dat
 autorun\dat01\ap11.dat
 autorun\dat01\ap12.dat
 autorun\dat01\ap13.dat
 autorun\dat01\ap14.dat
 autorun\dat01\ap15.dat
 autorun\dat01\ap16.dat
 autorun\dat01\ap17.dat
 autorun\dat01\ap18.dat
 autorun\dat01\ap19.dat
 autorun\dat01\ap2.dat
 autorun\dat01\ap20.dat
 autorun\dat01\ap21.dat
 autorun\dat01\ap22.dat
 autorun\dat01\ap23.dat
 autorun\dat01\ap24.dat
 autorun\dat01\ap25.dat
 autorun\dat01\ap26.dat
 autorun\dat01\ap27.dat
 autorun\dat01\ap28.dat
 autorun\dat01\ap29.dat
 autorun\dat01\ap3.dat
 autorun\dat01\ap30.dat
 autorun\dat01\ap31.dat
 autorun\dat01\ap32.dat
 autorun\dat01\ap33.dat
 autorun\dat01\ap34.dat
 autorun\dat01\ap35.dat
 autorun\dat01\ap36.dat
 autorun\dat01\ap37.dat
 autorun\dat01\ap38.dat
 autorun\dat01\ap39.dat
 autorun\dat01\ap4.dat
 autorun\dat01\ap40.dat
 autorun\dat01\ap41.dat
 autorun\dat01\ap42.dat
 autorun\dat01\ap43.dat
 autorun\dat01\ap44.dat
 autorun\dat01\ap45.dat
 autorun\dat01\ap46.dat

© Copyright 1998-2018 PerkinElmer Informatics, Inc. All Rights Reserved. 8 of 14

ChemOffice v17.1 Release Notes

 autorun\dat01\ap47.dat
 autorun\dat01\ap48.dat
 autorun\dat01\ap49.dat
 autorun\dat01\ap5.dat
 autorun\dat01\ap50.dat
 autorun\dat01\ap51.dat
 autorun\dat01\ap52.dat
 autorun\dat01\ap53.dat
 autorun\dat01\ap54.dat
 autorun\dat01\ap55.dat
 autorun\dat01\ap56.dat
 autorun\dat01\ap57.dat
 autorun\dat01\ap58.dat
 autorun\dat01\ap59.dat
 autorun\dat01\ap6.dat
 autorun\dat01\ap60.dat
 autorun\dat01\ap61.dat
 autorun\dat01\ap62.dat
 autorun\dat01\ap63.dat
 autorun\dat01\ap64.dat
 autorun\dat01\ap65.dat
 autorun\dat01\ap66.dat
 autorun\dat01\ap67.dat
 autorun\dat01\ap68.dat
 autorun\dat01\ap7.dat
 autorun\dat01\ap8.dat
 autorun\dat01\ap9.dat
 autorun\Icons\3D.ico
 autorun\Icons\CD.ico
 autorun\Icons\CF.ico
 autorun\Icons\CO.ico
 autorun\Icons\CS.ico
 autorun\Icons\EN.ico
 autorun\Icons\FO.ico
 autorun\Icons\IN.ico

o * Installation
 Windows\Install.exe
 Windows\Install.ini
 Windows\MSCOMCTL.OCX
 Windows\QProGIF.ocx
 Windows\RICHTX32.OCX
 Windows\PerkinElmer\Activation\Activate.exe
 Windows\PerkinElmer\Activation\activationhelp.html
 Windows\PerkinElmer\Activation\FlxComm.dll
 Windows\PerkinElmer\Activation\FlxCore.dll
 Windows\PerkinElmer\Activation\concrt140.dll
 Windows\PerkinElmer\Activation\msvcp140.dll
 Windows\PerkinElmer\Activation\vccorlib140.dll
 Windows\PerkinElmer\Activation\vcruntime140.dll
 Windows\PerkinElmer\Activation\FNEactivationhelp.html
 Windows\PerkinElmer\Activation\registerproduct.html
 Windows\PerkinElmer\Activation\registerproductemail.html
 Windows\PerkinElmer\Activation\registerproductfax.html
 Windows\PerkinElmer\Activation\registerredirect.html
 Windows\PerkinElmer\ChemOffice\PerkinElmer_ChemDraw_Professional_17.1.msi
 Windows\PerkinElmer\ChemOffice\PerkinElmer_ChemOffice_64-bit_Support_17.1.msi
 Windows\PerkinElmer\ChemScript\PerkinElmer_ChemScript_17.1.msi
 Windows\ThirdParty\Microsoft\VCRedist\vcredist_x64.exe
 Windows\ThirdParty\Microsoft\VCRedist\vcredist_x86.exe

© Copyright 1998-2018 PerkinElmer Informatics, Inc. All Rights Reserved. 9 of 14

ChemOffice v17.1 Release Notes

 Windows\ThirdParty\NETInstaller\dotNetFx40_Full_x86_x64.exe
 Windows\ThirdParty\Python\python-3.2.2.msi
 Windows\ThirdParty\PythonExt\pywin32-217.win32-py3.2.exe
 Windows\_images\progress.gif
o Docs\ChemOffice v17.1 Release Notes.pdf (This document)
o Docs\DT-17.1 Hardware Software Guide.pdf
o Manuals
 Chem3D.pdf
 ChemDraw.pdf
 ChemFinder.pdf

• ChemDraw Prime (Win/Mac)

o * DVD navigation
 autorun.inf
 CD.ico
 ChemDrawPrime171.cdd
 ChemDrawPrime171.exe
 lua5.1.dll
 lua51.dll
 autorun\dat01\ap1.dat
 autorun\dat01\ap10.dat
 autorun\dat01\ap11.dat
 autorun\dat01\ap12.dat
 autorun\dat01\ap13.dat
 autorun\dat01\ap14.dat
 autorun\dat01\ap15.dat
 autorun\dat01\ap16.dat
 autorun\dat01\ap17.dat
 autorun\dat01\ap18.dat
 autorun\dat01\ap19.dat
 autorun\dat01\ap2.dat
 autorun\dat01\ap20.dat
 autorun\dat01\ap21.dat
 autorun\dat01\ap22.dat
 autorun\dat01\ap23.dat
 autorun\dat01\ap24.dat
 autorun\dat01\ap25.dat
 autorun\dat01\ap26.dat
 autorun\dat01\ap27.dat
 autorun\dat01\ap28.dat
 autorun\dat01\ap29.dat
 autorun\dat01\ap3.dat
 autorun\dat01\ap30.dat
 autorun\dat01\ap31.dat
 autorun\dat01\ap32.dat
 autorun\dat01\ap33.dat
 autorun\dat01\ap34.dat
 autorun\dat01\ap35.dat
 autorun\dat01\ap36.dat
 autorun\dat01\ap37.dat
 autorun\dat01\ap38.dat
 autorun\dat01\ap39.dat
 autorun\dat01\ap4.dat
 autorun\dat01\ap40.dat
 autorun\dat01\ap41.dat
 autorun\dat01\ap42.dat
 autorun\dat01\ap43.dat
 autorun\dat01\ap44.dat

© Copyright 1998-2018 PerkinElmer Informatics, Inc. All Rights Reserved. 10 of 14

ChemOffice v17.1 Release Notes

 autorun\dat01\ap45.dat
 autorun\dat01\ap46.dat
 autorun\dat01\ap47.dat
 autorun\dat01\ap48.dat
 autorun\dat01\ap49.dat
 autorun\dat01\ap5.dat
 autorun\dat01\ap50.dat
 autorun\dat01\ap51.dat
 autorun\dat01\ap52.dat
 autorun\dat01\ap53.dat
 autorun\dat01\ap54.dat
 autorun\dat01\ap55.dat
 autorun\dat01\ap56.dat
 autorun\dat01\ap57.dat
 autorun\dat01\ap58.dat
 autorun\dat01\ap59.dat
 autorun\dat01\ap6.dat
 autorun\dat01\ap60.dat
 autorun\dat01\ap61.dat
 autorun\dat01\ap62.dat
 autorun\dat01\ap63.dat
 autorun\dat01\ap64.dat
 autorun\dat01\ap65.dat
 autorun\dat01\ap66.dat
 autorun\dat01\ap67.dat
 autorun\dat01\ap68.dat
 autorun\dat01\ap7.dat
 autorun\dat01\ap8.dat
 autorun\dat01\ap9.dat
 autorun\Icons\3D.ico
 autorun\Icons\CD.ico
 autorun\Icons\CF.ico
 autorun\Icons\CO.ico
 autorun\Icons\CS.ico
 autorun\Icons\EN.ico
 autorun\Icons\FO.ico
 autorun\Icons\IN.ico

o * Installation
 Windows\Install.exe
 Windows\Install.ini
 Windows\MSCOMCTL.OCX
 Windows\QProGIF.ocx
 Windows\RICHTX32.OCX
 Windows\PerkinElmer\Activation\Activate.exe
 Windows\PerkinElmer\Activation\activationhelp.html
 Windows\PerkinElmer\Activation\FlxComm.dll
 Windows\PerkinElmer\Activation\FlxCore.dll
 Windows\PerkinElmer\Activation\concrt140.dll
 Windows\PerkinElmer\Activation\msvcp140.dll
 Windows\PerkinElmer\Activation\vccorlib140.dll
 Windows\PerkinElmer\Activation\vcruntime140.dll
 Windows\PerkinElmer\Activation\FNEactivationhelp.html
 Windows\PerkinElmer\Activation\registerproduct.html
 Windows\PerkinElmer\Activation\registerproductemail.html
 Windows\PerkinElmer\Activation\registerproductfax.html
 Windows\PerkinElmer\Activation\registerredirect.html
 Windows\PerkinElmer\ChemOffice\PerkinElmer_ChemDraw_Prime_17.1.msi
 Windows\PerkinElmer\ChemOffice\PerkinElmer_ChemOffice_64-
bit_Support_for_ChemDraw_Prime_17.1.msi

© Copyright 1998-2018 PerkinElmer Informatics, Inc. All Rights Reserved. 11 of 14

ChemOffice v17.1 Release Notes

 Windows\ThirdParty\Microsoft\VCRedist\vcredist_x64.exe
 Windows\ThirdParty\Microsoft\VCRedist\vcredist_x86.exe
 Windows\ThirdParty\NETInstaller\dotNetFx40_Full_x86_x64.exe
 Windows\_images\progress.gif
o Docs\ChemOffice v17.1 Release Notes.pdf (This document)
o Docs\DT-17.1 Hardware Software Guide.pdf
o Manuals
 ChemDraw.pdf

• ChemDraw Active-X EntConst (admin/non-admin)

o * Installation
 PerkinElmer_ChemDraw_ActiveX_Enterprise_Constant_17.1.msi
 Install.exe
 Install.ini
 MSCOMCTL.OCX
 QProGIF.ocx
 RICHTX32.OCX
 ThirdParty\Microsoft\VCRedist\vcredist_x86.exe
 ThirdParty\Microsoft\NETInstaller\dotNetFx40_Full_x86_x64.exe
 _images\progress.gif
o Docs\ChemOffice v17.1 Release Notes.pdf (This document)
o Docs\DT-17.1 Hardware Software Guide.pdf

• CDAXEntConstNonAdmin
o *Installation
 PerkinElmer_ChemDraw_ActiveX_Enterprise_Constant_NA_17.1.msi

5 Known Issues, Limitations and Workarounds

The following list describes the known issues, limitations, and workarounds for ChemOffice17.1:

• IUPAC atom numbering scheme after Structure to Name conversion will be displayed only in the expanded
regions of the molecule.

• Persisting HELM sequences is only supported using the CDX and CDXML formats, due to various limitations
in other formats.

• The Paste as HELM feature does not support parsing of the following information in HELM strings:
o Monomer ambiguity
o Hydrogen parings for DNA
o List of polymer groups
o Extended annotations

• The latest version of GAMESS supported by Chem3D V17.1 is the 64 bit version of GAMESS 2013. Full
details of system prerequisites are given at
https://www.cambridgesoft.com/support/DesktopSupport/KnowledgeBase/FAQ/details/Default.aspx?TechNot
e=2145.

• The full representation of HELM sequences is only supported using CDX or CDXML files, and HELM strings.
Other file formats, such as mol or sdf, lack the ability to fully represent the sequences and are not supported
as a way to persist HELM sequences.

• The Enhanced Retrosynthesis feature may not provide all desired reaction results if:
o Query product contains stereochemistry undefined stereo-center atoms.

© Copyright 1998-2018 PerkinElmer Informatics, Inc. All Rights Reserved. 12 of 14

ChemOffice v17.1 Release Notes

Workaround: For optimum results, present such queries with all stereo-center atoms defined
using relevant stereo-bond connectivity.
o Query product contains erroneous atom definition (e.g., valence errors, wrong atom types etc.).
 Workaround: Make sure to rectify atom errors in the query product before doing enhanced
retrosynthesis.

• It has been observed that Copying and Pasting of structure from ChemDraw to MS Word 15.x version results
in pasting the structure as SMILES string if the system has a previous version of ChemDraw installed and/or
if the system was upgraded to the latest OS (Sierra/High Sierra).
o Workaround: Use Paste Special (Edit>Paste Special) option in MS Word 15.x to paste the structure
and then select “PDF” option. This way you can paste a ChemDraw structure in word and then copy it
back to ChemDraw for editing.
• Enhanced Retrosynthesis results will show only the queried product as the end product of each reaction even
if more side products are expected for any reaction.

• It was observed that ChemDraw OLE editing in MS Office 2010/2013/2016 applications failed to work after
installing Windows 10 Anniversary update (1607).
o This was later fixed by Microsoft update:
Cumulative Update for Windows 10 Version 1607 for x64-based Systems (KB4013429) (OS Build
14393.953)

• The ChemDraw & Chem3D Plugins are no longer part of any ChemOffice/ChemDraw 17.1 Windows
packages (ChemOffice Professional, ChemDraw Professional & Prime). However, users can continue to use
any older version of the ChemDraw & Chem3D Plugin along with ChemDraw 17.1 applications. The
ChemDraw & Chem3D ActiveX controls are still included and can be used with IE.

• When try to add/edit a structure in a ChemOffice sheet that was created in a system with opposite bit
architecture (32 or 64) compared to the current system bit architecture (64 or 32) via ‘Edit in Excel’ option
from Office 365 Online portal, a (1) ‘Cannot run Macro …’ error or (2) ‘Link update’ failure may appear by
blocking that operation.
o Workaround: (1) Keep your local MS Excel running before selecting the ‘Edit in Excel’ option from
Office 365 online portal.
or
(2) Choose Edit Links option and remove the existing *.xla link by clicking the Break Link button. Now
you will be able to edit the contents in that file and save the changes. This step may need to be
repeated in the other system if you want to edit the same document there.

• When a ChemDraw structure is copied from Keynote/Pages/Numbers document and pasted to ChemDraw
Document, it loses the structure information.

• Cannot embed Chem3D models in MS PowerPoint 2010, 2013 and 2016.

• The contents in a document uploaded to ChemDraw Cloud with a Japanese file name may lose when modify
contents in it and save. This issue will not appear if the file name is in English.

• The Search SciFinder feature may not provide accurate results for the following query types:
o Query bond types ‘Any’, ‘S/A’, ‘D/A’, and ‘S/D’
o Stereo bond types: Dashed, Hashed, Bold, Hollow Wedged, and Wavy
o Multiple bond types: Quadruple, Dative, Tautomeric (Dashed Double), Aromatic (Double Dashed
Double), and Double Either
o Resonance delocalized ring forms
o Chemical Symbols Radical, Lone Pair, Radical Cation, and Radical Anion
o Isotopic labels
o Multiple Group Bracket Repeat Patters ‘Either/Unknown’ and ‘Head-To-Head’
o Multiple Group Brackets crossing multiple bonds or no bonds of the query structure
o Nested bracketed groups
o Anonymous alternative group labels with more than (1) non-H atoms
o Generic atom labels for Exact Search

© Copyright 1998-2018 PerkinElmer Informatics, Inc. All Rights Reserved. 13 of 14

ChemOffice v17.1 Release Notes

• ChemScript17 may not work properly after installing ChemOffice Professional on a Windows 8.1, 64-bit
machine.
o Workaround: Reboot your machine after installing ChemOffice Professional on a Windows 8.1, 64-bit
system. ChemScript should operate normally.

• With systems running Windows 8.1 (64 bit) and Visual Studio C# 2010 Express, the demo (Demo.csproj)
might crash due to a possible error in VS 2010 Express conversion process.
o Workaround: Manually remove the "Demo.exe.config" file from the
"C:\ProgramData\PerkinElmerInformatics\ChemOffice2017\ChemScript\Examples\Demo”. This will
prevent this issue from recurring on systems with Visual C# 2010 Express.

• There are few known issues with NMR computations with the default GAMESS installer- “2013-GAMESS-
PGI-LINUX-Blas.msi”.
o Workaround: Install “2013-GAMESS-PGI-FAST.msi” installer from the GAMESS download page.

6 Technical Support
PerkinElmer Informatics Support supports this software. Please contact your Sales or Services representative for
further information about ChemOffice v17.1.
www.perkinelmer.com/informatics/support
PerkinElmer Inc. | For the Better
HUMAN HEALTH | ENVIRONMENTAL HEALTH
940 Winter Street | Waltham, MA 02451

© Copyright 1998-2018 PerkinElmer Informatics, Inc. All Rights Reserved. 14 of 14