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practical and experimental pharmacology

Book · January 2012

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Ali Esmail Al-Snafi

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 THI QAR UNIVERSITY COLLEGE OF MEDICINE

Practical and Experimental Pharmacology

Prof Dr Ali Esmail Al-Snafi

2012
PREFACE
This laboratory Guide represent a blend of ideas from other
laboratory manuals, text books, and one’s past experience in
pharmacology laboratories . The Guide is written for the third year
students .It is intended to be an adjunct to pharmacology lectures
and text-book materials .
The experiments are designed to acquaint the student with various
pharmacological and toxicological principles or concepts . A brief
introductory material is provided in the experiments in order to
understand the theoretical background .
Many well – known procedures for preparing animals or isolated
organs are not described in full detail . The procedures have been
kept as simple as possible , since the experiments depend on student
participation . The doses given throughout the guide are usually
effective doses and may have to be adjusted to give the desired
responses .
The students are expected to read each experiment thoroughly before
attending the lab . and collect data carefully ; then tabulate and
explain the results . They should discuss the results in detail with the
instructor.
We welcome any comments on the experiments from our colleagues
which would improve the quality of the guide for pharmacology and
toxicology instruction .
 THI QAR UNIVERSITY COLLEGE OF MEDICINE
Practical and Experimental Pharmacology
Experiment Page
1-GENERAL INSTRUCTIONS TO STUDENTS
2-ROUTE OF ADMINISTRATION OF DRUGS IN LABOROTORY ANIMAL
3-ROUTE OF DRUG ADMINISTRATION OF DRUGS IN HUMAN
4-DRUG FORMULATION AND DOSAGE FORMS
5- HOUSEHOLD MEASURES, METROLOGY, AND DOSE ESTIMATION
6-PRESCRIPTION ORDER WRITING
7- ABSORPTION AND EXCRETION OF DRUGS
8 –EFFECTS OF CNS STIMULANT DRUGS
9- ACTIVITY OF NON-STEROIDAL ANTIIFLAMMATORY AGENTS
10- EVALUATION OF ANALGESICS
11- EFFECT OF ANTIPYRETICS ON INDUCED FEVER IN RATS
12- GENERAL ANAESTHESIA
13- LOCAL ANAESTHESIA
14- DRUGS ANTAGONISM MORPHINE- NALORPHENE
15- ANTAGONISM OF ORGANOPHOSPHORUS CHOLINESTERASE INHIBITORS BY
ATROPINE AND 2-PAM
16- TOXICITY OF ACETYLSALICYLIC ACID ( ASPIRIN) AND
ACETAMINOPHEN ( PARACETAMOL )
17- DOSE RESPONSE RELATIOSHIP : DETERMINATION OF THE ED50 AND LD50 FOR
THIOPENTAL
18- ACTIONS OF DRUGS ON THE EYE
19- THE DIURETIC ACTIVITY OF SOME DRUGS IN THECONSCIOUS RAT
20- EXPREIMENTS WITH INTESTINAL SMOOTH MUSCLE
21- DRUGS AND THE RAT UTERUS
22- TESTS FOR INVESTIGATION OF ACTIVE PRINCIPLES OF PLANTS..
23- DRUGS AND PERFUSED RABBIT HEART
24- EFFECTS OF DRUGS ON THE BLOOD PRESSURE IN ANESTHETIZED RAT..
25- ANALYTICAL TECHNIQUES AND DRUGS MEASUREMENTS
26-MUSCLE RELAXANT PROPERTIES OF DIAZEPAM IN MICE
27-THE COMPULSIVE BEHAVIOUR INDUCED BY APOMORPHINE AND ITS
MODIFICATION BY CHLORPROMAZINE

SIX PRESCRIPING CESSIONS

PRESCRIPTION OF CNS DRUGS
PRESCRIPTION OF GIT DRUGS
PRESCRIPTION OF RESPIRATORY SYSTEM DRUGS
PRESCRIPTION OF CARDIOVASCULAR DRUGS
PRESCRIPTION OF HORMONES PREPARATIONS
PRESCRIPTION OF ANTIMICROBIAL DRUGS

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