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been proposed, and one among them introduced the term “angle
Purpose: To study the change in intraocular pressure (IOP) and closure hypertension” to refer to patients with angle closure and
angle status after phacoemulsification in a cohort of primary angle high intraocular pressure (IOP) in the absence of glaucomatous
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closure hypertension (PACHT) patients. optic nerve head (ONH) and visual field changes.2 This group of
Setting: Tertiary Eye Care, India. patients are frequently met with in routine glaucoma practice,
and disregarding their IOP because of the presence of a healthy
Design: Prospective interventional case-series. ONH may end up in progression. In fact, 20% of treated pri-
Methods: Case-series of 18 eyes of 18 patients. Preoperative biometry mary angle closure hypertension (PACHT) eyes are known to
including axial length, anterior chamber depth (ACD), lens thickness, progress to primary angle closure glaucoma (PACG).3
and central corneal thickness were studied. Preoperative and post- Lens extraction for PACD is a topic of growing
operative IOP, number of topical glaucoma medications, angle swept interest, yet with unsettled conclusions. The ample research
source optical coherence tomography (SS-OCT) parameters of nasal available on this topic is primarily focused on PACG, or
and temporal angle opening distance, trabecular iris space area, poorly categorized PACD.4–8 Hence, we decided to review
scleral spur angle, lens vault and circumferential iridotrabecular
contact (ITC) were studied and their correlations derived.
and put forth the changes occurring postcataract surgery in
PACHT subgroup of PACD.
Results: The mean preoperative IOP, 31 ± 6 mm Hg, decreased to The standard practice for clinical diagnosis of angle
14 ± 1 mm Hg at 6-months postoperative period, P < 0.001, a fall closure is by gonioscopy. However, it is a contact procedure,
by 58 ± 14%. The number of glaucoma medications reduced from requires considerable experience and is subjective. The
4(3-5) to 2(1-3), P < 0.001. All SS-OCT studied parameters denoted recent noncontact diagnostic modalities such as Anterior
significant angle widening postsurgery. The ITC % reduced from 52
Segment Optical Coherence Tomography (ASOCT) with
(16-100) to 19(0-97), P < 0.001. The preoperative ITC showed
moderate to strong correlation with all preoperative nasal and the angle module help in objective assessment of angle and
temporal angle parameters. It also showed moderate positive corre- their quantification. A step ahead is the Swept-Source (SS)
lation with percentage fall in IOP at 1-month postoperative period. ASOCT, in which 3-Dimensional angle analysis is possible,
The preoperative ACD showed significant negative correlation with which computes percentage of circumferential irido-
preoperative and postoperative ITC. trabecular contact (ITC), shown to have good diagnostic
ability in picking up angle closure.9,10 Changes in the
Conclusions: PACHT patients benefit significantly from cataract
surgery with marked angle widening, IOP reduction and a decrease anterior chamber and angle parameters postiridotomy and
in the number of glaucoma medications. The SS-OCT derived cir- postcataract surgery have been widely studied on Time-
cumferential iridotrabecular contact index can be used as the single Domain and Fourier-Domain OCT (Visante, Carl Zeiss
best parameter to indicate the preoperative angle status and predict Meditec, Dublin, CA).11,12 Kasai et al13 studied angle
postoperative change in IOP, as against the numerous single section changes using SSOCT, however, ITC was not looked at.
measured angle parameters. Very few studies have characterized angle changes postir-
idotomy and postcataract surgery using SSOCT and cir-
Key Words: swept-source angle optical coherence tomography,
cumferential ITC.14,15 Our study adds to these by relating
iridotrabecular contact, primary angle closure hypertension,
their clinical bearing on intraocular pressure changes post-
phacoemulsification
cataract surgery.
(J Glaucoma 2019;28:105–110)
METHODS
It is a case series of 18 eyes of 18 patients. PACHT was
P rimary angle closure disease (PACD) constitutes a spectrum
of varying disease severity, ranging from mere suspect to
established angle closure glaucoma.1 Various classifications have
defined by the presence of shallow anterior chamber (AC)
with Van-Herick grade 1-2, an occludable angle ± synechial
angle closure of at least 180 degrees on indentation gonio-
scopy, IOP ≥ 22 mm Hg on 2 different occasions, ONH cup-
Received for publication July 18, 2018; accepted November 15, 2018. disc ratio (CDR) ≤ 0.6 with healthy rim and normal visual
From the Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All
India Institute of Medical Sciences, New Delhi, India.
fields. PACHT patients with immature senile nuclear scle-
Disclosure: The authors declare no conflict of interest. rosis ≥ grade II were included.16 We adhered to the tenets of
Reprints: Dewang Angmo, MD, DNB, FRCS, FICO, MNAMS, Dr. Declaration of Helsinki and a written informed consent was
Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of obtained from all the study participants. Ethical clearance
Medical Sciences, New Delhi 110029, India (e-mail: dewang45@gmail.
com).
was obtained from our Institutional Ethics Committee.
Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved. All cases were assessed by preoperative Snellen visual
DOI: 10.1097/IJG.0000000000001137 acuity chart, slit-lamp biomicroscopy, Goldmann applanation
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J Glaucoma Volume 28, Number 2, February 2019 Changes in IOP and Angle After Phaco in PACHT
ACD showed moderate negative correlation with both pre- causing angle closure has been quantified by the lens vault
operative and postoperative ITC (ρ = −0.52; −0.58; P = 0.02, (LV). Shabana et al20 divided PACG into 4 groups based on
0.01, respectively). In addition, the preoperative ITC corre- their mechanism of angle closure, and those because of
lated well with the postoperative ITC (ρ = 0.70, P = 0.001). exaggerated LV had a value of 1.05 ± 0.03. The mean LV in
our study was 0.75 ± 0.22 and when lens extraction was
DISCUSSION done, there was significant reduction in IOP and angle
The “primary angle closure” category of International opening, implying that PACD is a multifactorial disease.12
Society of Geographical and Epidemiological Ophthalmology Numerous parameters have been described in angle
(ISGEO) classification encompasses cases which have an OCT to determine their status and predict the IOP reduction
occludable angle and features suggestive of past angle closure postsurgery.21,22 These were primarily single section
attacks such as peripheral anterior synechiae (PAS), iris whirling, parameters, and do not necessarily reflect the 360 degrees
blotchy angle pigmentation, glaukomflecken and raised IOP.18 circumferential angle status. Moreover, even within the
However, this classification suits better for prevalence surveys, single section, the nasal and temporal parameters are not
and hence, practical circumstances such as the PACHT, more usually identical (Fig. 1), underscoring the variations in
often met in day-to-day practice, needs emphasis. angle within a single eye. Kong et al23 showed that appo-
PACD is commoner in India than the west, primarily sitional angle closure was maximal in the superior quadrant,
attributed to the smaller AL leading to an occludable angle. followed by inferior, nasal and temporal angles in that order
For the same reason, it is commoner in females also, being in primary angle closure suspects. Hence, a single section
reaffirmed by our observation.19 The contribution of lens in study of multiple angle parameters may still be misleading,
and a solitary parameter that would be able to connote the
circumferential angle status is highly desirable. By our
observations, the preoperative ITC had moderate to strong
TABLE 4. Correlation Between Preoperative Angle Parameters correlation with all preoperative studied angle parameters
and % Change in IOP at Postop 1 Month (Table 5) and hence, we propose that ITC may be used as
% Change in IOP the single best parameter to indicate the preoperative angle
status. Also correlating with the % change in IOP post-
Preoperative Variables Spearman Correlation Value P surgery, it may be helpful in predicting the IOP drop
Nasal AOD500 −0.46 0.05 expected after cataract surgery in PACHT patients.
Nasal AOD750 −0.52 0.03* The use of SS-OCT to assess ITC has the benefit of
Nasal TISA500 −0.83 < 0.001* being objective, avoiding interobserver variations, and gives
Nasal TISA750 −0.72 0.001* the overall circumferential status (Fig. 2) as compared with
Nasal SS angle −0.40 0.12 the other parameters that reflect the change in a single fixed
Temporal AOD500 −0.58 0.01* section. However, manually marking the scleral spur and
Temporal AOD750 −0.30 0.23 end-point in numerous sections is time-consuming and if
Temporal TISA500 −0.67 0.003* done by the same observer, would be more reliable.
Temporal TISA750 −0.63 0.006*
Liu et al12 had presented an ASOCT based case series
Temporal SS angle −0.34 0.19
Lens vault 0.02 0.92 with prototype examples for each mechanism of primary
Iridotrabecular contact 0.53 0.02* angle closure. They showed that the amount of ITC
remaining after cataract surgery may be because of
Spearman rank correlation applied. peripheral anterior synechiae or a plateau iris phenomenon.
IOP indicates intraocular pressure.
Bold values indicate statistically significant.
Our study included eyes with both occludable angles and
*P < 0.05 considered significant. synechial angle closure, and the SS-OCT derived ITC does
not differentiate between the two. Postphacoemulsification,
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Selvan et al J Glaucoma Volume 28, Number 2, February 2019
TABLE 5. Correlation Between Preop Iridotrabecular Contact (ITC) and Other Preoperative Angle Parameters
Nasal Temporal
AOD500 AOD750 TISA500 TISA750 SS Angle AOD500 AOD750 TISA500 TISA750 SS Angle
Preop ITC ρ (P) −0.50 −0.67 −0.69 −0.71 −0.61 −0.78 −0.62 −0.66 −0.78 −0.67
(0.032)* (0.002)* (0.001)* ( < 0.001)* (0.009)* ( < 0.001)* (0.006)* (0.002)* ( < 0.001)* (0.003)*
Spearman rank correlation test applied.
Bold values indicate statistically significant.
*P < 0.05 considered significant.
though the ITC decreased significantly with respect to their The preoperative and postoperative ITC showed significant
preoperative status, yet many eyes showed some amount of negative correlation with preoperative ACD, implying that a
residual ITC, directly proportional to their preoperative shallower AC may be associated with more extensive irido-
ITC (Fig. 3). It may most probably be because of persistent trabecular contact presurgery and postsurgery. Thus, the ACD
PAS or anteriorly placed ciliary body, in concordance with can be a preferable biometric parameter in place of ITC in the
Liu and colleagues’ findings. absence of SS-OCT facility.
FIGURE 1. Swept source anterior segment optical coherence tomography picture. A, Preoperative narrow-angle. B, Postoperative
widening of angle and their respective parameters. “x” indicates scleral spur and “+” indicates iridotrabecular endpoint. Figure 1 can be
viewed in color online at www.glaucomajournal.com.
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J Glaucoma Volume 28, Number 2, February 2019 Changes in IOP and Angle After Phaco in PACHT
FIGURE 2. Swept source anterior segment optical coherence tomography picture showing a decrease in iridotrabecular contact.
A, Preoperative image. B, Postoperative image. “x” indicates scleral spur and “+” indicates iridotrabecular endpoint. Figure 2 can be
viewed in color online at www.glaucomajournal.com.
The main limitation of our study is the small sample To conclude, PACHT patients benefit significantly from
size and short-term follow-up. Also, the novel iris parame- cataract surgery with marked angle widening, reasonable IOP
ters could have added more value to this observation. reduction and decrease in the number of glaucoma medi-
Phacoemulsification along with goniosynechialysis have also cations, however, a single best parameter to predict this event is
been studied in PACD24; however, our group of patients lacking at present. By our observation, the SS-OCT measured
have shown significant short-term success with the former preoperative ITC index correlated well with all other angle
alone. Nevertheless, the proportion of patients with persis- parameters studied on 2 quadrants, the nasal and temporal,
tent ITC because of PAS could have benefitted more from and may be used as the single best parameter to predict the
added goniosynechiolysis. On the other hand, lens extrac- postoperative percentage decrease in intraocular pressure. We
tion with/without goniosynechiolysis may not alone suffice also highlight that a study of single-section angle parameters
in cases of advanced trabecular meshwork damage. may not always be indicative of the entire angle status.
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Selvan et al J Glaucoma Volume 28, Number 2, February 2019
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