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R E L I A B L E I N F O R M A T I O N F O R A H E A L T H I E R L I F E
VOLUME 23 NUMBER 2 FEBRUARY 2005
Coming in March
DEPRESSION Ascending
A definable medical disorder. Descending
colon colon
MEDITATION
Tuning the mind to help heal the Area of
body. diverticulosis
DELAYING DEMENTIA
Current evidence and future study. Cecum
PRESCRIBED VITAMINS
Sometimes the drug of choice.
Sigmoid
Rectum
colon
In most people with diverticulosis, there’s evidence of thickening of the muscle layers in the
sigmoid colon. This may lead to increased pressure in this region of the colon, which can cause
weak spots to balloon out, resulting in the formation of tiny pouches (diverticulosis).
2 M AYO C L I N I C H E A LT H L E T T E R
FEBRUARY 2005
Fatigue
News and our views
A cue to rest, or a sign
Cardiac rehabilitation after heart attack improves survival
of something more?
A Mayo Clinic study found that people who participated in a med-
ically supervised exercise program after having had a heart attack Lately, you’ve been so exhausted
improved their chances of surviving at least three years by more than you can barely drag yourself out of
50 percent. bed in the morning. Throughout the
The study, published in the Sept. 1, 2004, issue of the Journal of day, you find yourself longing for a
the American College of Cardiology, involved more than 1,800 peo- good nap. Why are you so tired all
ple who’d had heart attacks between 1982 and 1998. In the three of the time?
years after their heart attacks, nearly half of the deaths were attributed There are a number of reasons
to not participating in cardiac rehabilitation. By comparison, those why fatigue may be dragging you
who did participate in cardiac rehabilitation had the same three-year down. Most often, it’s a result of
survival rate as would be expected among people of the same age lifestyle factors, including poor
and sex who’d never had a heart attack. The study also found that sleep, stress or a schedule that’s too
older adults and women of all ages were less likely to participate in full. But dramatic or prolonged
cardiac rehabilitation programs after a heart attack. fatigue may be a sign of an under-
Mayo Clinic cardiologists say their findings point to the poten- lying medical problem that requires
tial for improved survival among a large proportion of people who’ve a doctor’s care.
had heart attacks, especially among women and the elderly. ❒
The daily drag
A combination treatment for localized prostate cancer Fatigue — also referred to as
It’s estimated that over 230,000 new prostate cancer cases were diag- weariness, tiredness, exhaustion,
nosed in 2004. For some men, external radiation therapy is the treat- lethargy or lack of energy — is a
ment of choice for prostate cancer that hasn’t spread. This is espe- condition that challenges doctors.
cially true for older men and for those who can’t have surgery due It’s hard to define because it can feel
to other health problems. Radiation therapy allows for a good chance different for each individual.
of survival. However, a recent study shows that a combination of radi- Fatigue can accompany many
ation therapy and hormone therapy may provide even better results. physical ailments. It can also be
The study, in the Aug. 18, 2004, Journal of the American Medical related to everyday lifestyle. A lack
Association, followed 206 men who had been diagnosed with inter- of sleep may leave you drowsy and
mediate- or high-risk prostate cancer that hadn’t spread. Half the group unable to manage your daily rou-
was given radiation therapy alone. The other half was given a six- tine. Stress and anxiety may wear
month regimen of androgen suppressive hormone therapy, then radi- you down. Little physical activity
ation. This hormone therapy suppresses or blocks the male sex hor- may cause you to run on “low,”
mones that can stimulate the growth of prostate cancer cells. while too much physical activity can
Researchers found a significant survival advantage linked to the exhaust you. And poor eating habits
combination treatment. Almost five years after treatment, 88 per- deprive your body of the fuel it
cent of the men who received the combination treatment were still needs to make it through the day.
alive, with no deaths due to prostate cancer. Of those who had radi- Certain medications, including
ation alone, 78 percent survived, with six prostate-related deaths. many anti-anxiety drugs, antihista-
Combination treatment has become increasingly recognized as a mines, and some heart and blood
preferred choice for some men. Mayo Clinic doctors say that the study, pressure drugs such as beta block-
which shows improved outcomes, further supports the use of radia- ers, can also cause fatigue. Cold
tion and hormones together. However, data on this treatment over an medications and pain relievers that
extended number of years aren’t yet available. contain caffeine and other stimu-
If you have prostate cancer, your doctor can help determine which lants can interfere with sleep.
option may be best for you. ❒ Talk to your doctor if you’re
extremely tired or unable to regain
M AYO C L I N I C H E A LT H L E T T E R 5
FEBRUARY 2005
Second opinion
Questions and our answers rated fat in the liver and has neutral Beta blockers also reduce car-
effects on cholesterol levels. Despite diovascular complications among
Q: Are certain types of chocolate this, if a chocolate’s ingredients list high-risk people undergoing major
healthier than others? includes milk or the words “hydrog- surgeries that aren’t heart-related.
enated” or “partially hydrogenated,” If you’re already taking a beta
A: Yes, recent studies have sug- it’s typically more likely to contribute blocker before surgery, your doctor
gested that there may be health ben- to higher cholesterol. likely will have you continue taking
efits to eating certain types of choco- While chocolate may have some it. If you don’t normally take a beta
late in moderation. benefits, it’s best to keep it as an blocker, but have hypertension or
Chocolate contains flavonoids. occasional snack. ❒ are at high risk of other complica-
These natural antioxidants — also tions, your doctor may prescribe
found in tea, red wine, and some Q: I’m about to have elective sur- one. Although several factors may
fruits and vegetables — help limit gery. My doctor recommended that affect when to start beta blocker
the negative effects of lipoproteins, I start taking a drug called metopro- therapy, doctors typically recom-
which are components of the “bad” lol a few days before surgery to pro- mend starting a few days before
type of cholesterol, low-density tect my heart. How does this work? surgery. Therapy may continue while
lipoprotein (LDL) cholesterol. Flavo- you’re in the hospital, and may con-
noids may protect arteries and pre- A: Metoprolol (Lopressor) is in a tinue for a time after you’re home.
vent heart disease, stroke and ath- drug class known as beta blockers. However, this therapy may not
erosclerosis, a disease characterized Beta blockers are traditionally pre- be recommended if you have cer-
by clogged arteries. scribed to treat high blood pressure tain pre-existing conditions, includ-
The amount of flavonoids in (hypertension) and — more recent- ing asthma and significant low blood
chocolate depends largely on pro- ly — coronary artery disease. They pressure. Your doctor can determine
cessing. Chocolate products are de- block the effects of certain adrena- if the risks outweigh the benefits. ❒
rived from cocoa beans. To be made line-related hormones, slowing the
into their final product, though, vary- heart rate and lowering blood pres- Have a question or comment?
ing amounts of cocoa powder, co- sure. Other drugs in this class in- We appreciate every letter sent to Second
coa butter, milk (typically whole clude atenolol (Tenormin), propran- Opinion but cannot publish an answer to each
milk), sugar and other ingredients olol (Inderal) and others. question or respond to requests for consultation
on individual medical conditions. Editorial
are added. This often adds fat and Studies show that those who comments can be directed to:
reduces flavonoid content. The dark- take beta blockers before coronary Managing Editor, Mayo Clinic Health Letter,
er the chocolate, the higher it’s like- artery bypass surgery have lower 200 First St. S.W., Rochester, MN 55905, or
send e-mail to HealthLetter@Mayo.edu
ly to be in flavonoids. For example, death rates within 30 days than do
For information about Mayo Clinic services,
a bar of dark chocolate contains an those who don’t. Beta blocker ther- you may telephone any of our three facilities:
average of 53.5 milligrams (mg) of apy decreases the risk of major com- Rochester, Minn., (507) 284-2511;
flavonoids. A milk chocolate bar plications, and may help control an Jacksonville, Fla., (904) 953-2000;
Scottsdale, Ariz., (480) 301-8000 or visit
contains less than 14 mg. White irregular heartbeat (atrial fibrillation) www.MayoClinic.org
chocolate contains no flavonoids. — a common complication. Over-
The type of fat is also key. Cocoa all, outcomes tend to be improved Check out Mayo Clinic Health Information’s
butter is converted into an unsatu- even for those at higher risk. Web site, at www.MayoClinic.com