Beruflich Dokumente
Kultur Dokumente
Biomolecules 100 4
Enzymology 100 4
Metabolism 100 4
Core Course
Core Course
BIOCHEMISTRY
B.Sc. (Hons) I Year
Semester I
Core Course
BIOMOLECULES
Credit: 4
Total Lectures: 48
NOTE: The course will be evaluated out of 100 marks and will have the following
components of evaluation: Sessional for 10 marks, mid-semester examination of one
hour duration for 30 marks, end-semester examination of two hours for 60 marks.
Water: Physical properties and hydrogen bonding of water; structure of liquid water
and its solvent properties; hydrophobic interactions; ionization of H2O and ion
product of water; the pH scale; relationship between pH and pKa (Henderson-
Hasselbalch equation); buffers
RECOMMENDED BOOKS
BIOCHEMISTRY
B.Sc. (Hons) I Year
Semester II
Core Course
Credit: 4
Total Lectures: 48
NOTE: The course will be evaluated out of 100 marks and will have the following
components of evaluation: Sessional for 10 marks, mid-semester examination of one
hour duration for 30 marks, end-semester examination of two hours for 60 marks.
Adaptation and mutation: types of mutations and their effects; Significance of Gene
transfer in bacteria; Methods of Lateral gene transfer: transformation, transduction
and conjugation; their discovery and mechanism, Generalised and specialised
transduction; Temperate and virulent phages, lysogenic and lytic cycles,
Characteristics of plasmids, Transposable elements: Insertion sequence and
transposons.
Definitions of virus, viroids, virusoids and prion; General properties of viruses; Virus
structure; variations in size and shape/symmetry, Cultivation and detection of
viruses; Plaque formation and Haemagglutination inhibition test, Replication of
bacteriophages, animal viruses and retroviruses.
UNIT IV: VIRAL INFECTIONS (12 Lectures)
Acute viral infections - Influenza, dengue and yellow fever viruses, persistent viral
infections- Herpes/Hepatitis and AIDS; transformation and Cancer ; Role of vaccines
in prevention of viral infections, types of Polio vaccines.
RECOMMENDED BOOKS
BIOCHEMISTRY
B.Sc. (Hons) 2nd Year
Semester III
Core Course
ENZYMOLOGY
Credits: 4
Total Lectures: 48
NOTE: The course will be evaluated out of 100 marks and will have the following
components of evaluation: Sessional for 10 marks, mid-semester examination of one
hour duration for 30 marks, end-semester examination of two hours for 60 marks.
Kinetics of zero and first order reactions, effect of enzyme concentration, substrate
concentration temperature and pH on enzyme activity; enzyme inhibition (reversible
and irreversible inhibition). Evaluation of Km, Ki and Vmax in the presence of
inhibitors. Significance and evaluation of energy of activation and free energy.
UNIT IV: BI-SUBSTRATE KINETICS, ALLOSTERIC AND ISOENZYMES
(08 Lectures)
Bi-substrate enzymes (rapid equilibrium, random bi-bi, ordered bi-bi and ping-pong
bi-bi reactions). Allosteric enzymes – definition, behavior and physiological
significance. Isoenzymes – physiological and diagnostic significance.
RECOMMENDED BOOKS
BIOCHEMISTRY
B.Sc. (Hons) 2nd Year
Semester III
Ability Enhancement Discipline Centric Course
Credits: 2
Total Lectures: 24
NOTE: The course will be evaluated out of 100 marks and will have the following
components of evaluation: Sessional for 10 marks, mid-semester examination of one
hour duration for 30 marks, end-semester examination of two hours for 60 marks.
RECOMMENDED BOOKS
1. Physical Biochemistry: Principles and Applications (2010) 2nd ed., Sheehan, D.,
Wiley Blackwell (West Sussex), ISBN:978-0-470-85602-4 / ISBN:978-0-470-
85603-1
2. Physical Biochemistry: Applications to Biochemistry and Molecular Biology (1982)
2nd ed., Freifelder, D., W.H. Freeman and Company (New York), ISBN:0-7167-
1315-2 /ISBN:0-7167-1444-2.
BIOCHEMISTRY
B.Sc. (Hons) 2nd Year
Semester III
Ability Enhancement Discipline Centric Course
BIOSTATISTICS AND DATA ANALYSIS
Credits: 2
Total Lectures: 24
NOTE: The course will be evaluated out of 100 marks and will have the following
components of evaluation: Sessional for 10 marks, mid-semester examination of one
hour duration for 30 marks, end-semester examination of two hours for 60 marks.
BIOCHEMISTRY
B.Sc. (Hons) 2nd Year
Semester IV
Core Course IV
METABOLISM
Credits: 4
Total Lectures: 48
NOTE: The course will be evaluated out of 100 marks and will have the following
components of evaluation: Sessional for 10 marks, mid-semester examination of one
hour duration for 30 marks, end-semester examination of two hours for 60 marks.
History and background of the tricarboxylic acid (TCA) cycle; oxidation of pyruvate to
acetyl CoA; individual reactions of the TCA cycle; energetic of the cycle, anabolic
nature of TCA cycle; regulation of TCA cycle, electron transport oxidative
phosphorylation; Energy coupling hypothesis.
Nitrogen balance studies in man (normal, negative and positive nitrogen balance);
Urea cycle (preliminary account), transamination and deamination reactions,
comparative biochemistry of nitrogen excretion; metabolism of purines and
pyrimidines including regulation (preliminary account); Synthesis of biologically
active amines (e.g. epinephrone, non-epinephrine, dopamine, serotonin, α-amino-
butyric acid & histamine), glutathione as cofactor.
RECOMMENDED BOOKS
BIOCHEMISTRY
B.Sc. (Hons) 2nd Year
Semester IV
Ability Enhancement Discipline Centric Course
CLINICAL BIOCHEMISTRY
Credits: 2
Total Lectures: 24
NOTE: The course will be evaluated out of 100 marks and will have the following
components of evaluation: Sessional for 10 marks, mid-semester examination of one
hour duration for 30 marks, end-semester examination of two hours for 60 marks.
RECOMMENDED BOOKS
1. Medical Laboratory Technology - a Procedure Manual for Routine Diagnostic
Tests Vol. I (2010), Mukherjee, K.L., Tata Mc Graw–Hill Publishing Company Limited
(New Delhi). ISBN:9780070076594 / ISBN:9780070076631
BIOCHEMISTRY
B.Sc. (Hons) 2nd Year
Semester IV
Ability Enhancement Discipline Centric Course
PROTEIN PURIFICATION AND CHARACTERIZATION TECHNIQUES
Credits: 2
Total Lectures: 24
NOTE: The course will be evaluated out of 100 marks and will have the following
components of evaluation: Sessional for 10 marks, mid-semester examination of one
hour duration for 30 marks, end-semester examination of two hours for 60 marks.
RECOMMENDED BOOKS
1. Physical Biochemistry: Principles and Applications (2010) 2nd ed., Sheehan,
D., Wiley Blackwell (West Sussex), ISBN:978-0-470-85602-4 / ISBN:978-0-
470-85603-1
2. Physical Biochemistry: Applications to Biochemistry and Molecular Biology
(1982) 2nd ed., Freifelder, D., W.H. Freeman and Company (New York),
ISBN:0-7167-1315-2 /ISBN:0-7167-1444-2.
3. An Introduction to Practical Biochemistry (1998) 3rd ed., Plummer D. T., Tata
McGraw Hill Education Pvt. Ltd. (New Delhi), ISBN:13: 978-0-07-099487-4 /
ISBN:10: 0-07-099487-0.
Department of Biochemistry
Faculty of Life Sciences
AMU, Aligarh
B.Sc. (Hons) Syllabus
(Effective from 2015-16)
Passed in BOS held on 26.10.2015
BIOCHEMISTRY
B.Sc. (Hons) 2nd Year
Semester IV
Open Elective Course
OUTLINES OF BIOCHEMISTRY
Credits: 4
Total Lectures: 48
NOTE: The course will be evaluated out of 100 marks and will have the following
components of evaluation: Sessional for 10 marks, mid-semester examination of one
hour duration for 30 marks, end-semester examination of two hours for 60 marks.
1. BIOCHEMISTRY by Berg and L. Stryer 4th Ed. (1995) W.H. Freeman Co.,
San Francisco, USA.
2. G.L. Zubay BIOCHEMISTRY 4th Ed. (1998) W.C. Brown Publishers, USA.
3. Lehninger Principles of Biochemistry by Nelson and Cox (2008) Freeman
Press.
Department of Biochemistry
Faculty of Life Sciences
AMU, Aligarh
B.Sc. (Hons) Syllabus
(Effective from 2015-16)
Passed in BOS held on 26.10.2015
BIOCHEMISTRY
B.Sc. (Hons) Final year
Semester V
Core Course V
CONCEPTS OF CELL BIOLOGY
Credits: 4
Total Lectures: 48
NOTE: The course will be evaluated out of 100 marks and will have the following
components of evaluation: Sessional for 10 marks, mid-semester examination of one
hour duration for 30 marks, end-semester examination of two hours for 60 marks.
(b) Structure of a typical plant cell. Cell wall – composition, structure and
functions. Ultrastructure of chloroplast. Preliminary idea of light and dark
reactions of photosynthesis; Photophosphorylations.
Eukaryotic cell cycle, restriction point, and checkpoints. Cell division. Apoptosis
and necrosis - brief outline. Salient features of a transformed cell.
RECOMMENDED BOOKS
BIOCHEMISTRY
B.Sc. (Hons) Final year
Semester V
Core Course VI
CONCEPTS OF IMMUNOLOGY
Credits: 4
Total Lectures: 48
NOTE: The course will be evaluated out of 100 marks and will have the following
components of evaluation: Sessional for 10 marks, mid-semester examination of one
hour duration for 30 marks, end-semester examination of two hours for 60 marks.
(a) Innate and adaptive immunity: Cellular and humoral immunity, clonal selection
hypotheses.
(b) Definition of antigen, antibody, hapten, antigenic and haptenic determent,
structure of antibody molecules, classes of antibodies, polyclonal and
monoclonal antibodies.
(c) Primary and secondary immune response, idea of vaccination, adjuvant.
General properties of effector cells, B cells T cells (Tc), natural killer cells;
NKT cells. Primary and secondry lymphatic organs, spleen, thymus,
lymphnodes.
Brief introduction of autoimmunity and its causes. Organ specific and systemic
autoimmunity. Brief introduction of primary and secondary
immunodeficiencies.
RECOMMENDED BOOKS
1. Kuby Immunology (2007) 6th ed., Kindt, T.L., Goldsby, R.A. and Osborne,
B.A., W.H Freeman and Company (New York), ISBN:13: 978-0-7167-8590-3 /
ISBN: 10:0-7617-8590-0.
2. Immunology: A Short Course (2009) 6th ed., Coico, R and Sunshine, G., John
Wiley& sons, Inc (New Jersey), ISBN: 978-0-470-08158-7.
3. Janeway’s Immunobiology (2012) 8th ed., Murphy, K., Mowat, A., and Weaver,
C.T., Garland Science (London & New York), ISBN: 978-0-8153-4243-4.
BIOCHEMISTRY
B.Sc. (Hons) Final year
Semester V
Discipline Centric Elective Course
HUMAN PHYSIOLOGY
Credits: 4
Total Lectures: 48
NOTE: The course will be evaluated out of 100 marks and will have the following
components of evaluation: Sessional for 10 marks, mid-semester examination of one
hour duration for 30 marks, end-semester examination of two hours for 60 marks.
RECOMMENDED BOOKS
BIOCHEMISTRY
B.Sc. (Hons) Final year
Semester V
Discipline Centric Elective Course
Credits: 4
Total Lectures: 48
NOTE: The course will be evaluated out of 100 marks and will have the following
components of evaluation: Sessional for 10 marks, mid-semester examination of one
hour duration for 30 marks, end-semester examination of two hours for 60 marks.
1. Bioethics and Biosafety, 1st edition (2008), M. K Sateesh, I K International Pvt Ltd,
ISBN-13: 978-8190675703.
2. The Cambridge Textbook of Bioethics, 1st edition (2008), Peter A. Singer and A.
M. Viens;Cambridge University Press, ISBN-13: 978-0511545566.
4. Social science: An introduction to the study of society, 14th edition (2010), Hunt,
E. F.,andColander, D. C. ; Peason/Allyn and Bacon, Boston, ISBN-13: 978-
020570271.
5. Principles of Biomedical Ethics, 6th edition (2011), Beauchamp Tl, Childress JF;
Oxford University Press, 2001. ISBN-13: 978-0195143317.
6. A Companion to Bioethics, 2nd edition (2012), Helga Kuhse, Peter Singer; John
Wiley and Sons, ISBN-13: 978-1444350845.
8. Genetically Modified Organisms and biosafety, 1st edition (2004), Tomme Young.
ISBN-13: 978-2831707983.
10. Biosafety and Bioethics, 1st edition (2006), Rajmohan Joshi; Isha Books ISBN-
13: 978-8182053779.
11. Bioethics and biosafety in biotechnology, 1st edition (2007), V. Sreekrishna; New
Age International (P) Ltd., ISBN-13: 978-8122420852.
Department of Biochemistry
Faculty of Life Sciences
AMU, Aligarh
B.Sc. (Hons) Syllabus
(Effective from 2015-16)
Passed in BOS held on 26.10.2015
BIOCHEMISTRY
B.Sc. (Hons) Final year
Semester V
Discipline Centric Elective Course
Credits: 4
Total Lectures: 48
NOTE: The course will be evaluated out of 100 marks and will have the following
components of evaluation: Sessional for 10 marks, mid-semester examination of one
hour duration for 30 marks, end-semester examination of two hours for 60 marks.
Overview of major and minor nutrient components in the diet. Balanced diet and the
concept of RDA. Nutrient deficiencies; Kwashiorkor and Marasmus, Scurvy, beri beri,
pellagra and B12 deficiency, Xerophthalmia and night blindness, vitamin D
deficiency, vitamin K deficiency; their symptoms.
Obesity and eating disorders like anorexia nervosa and bullemia. Diabetes mellitus
as metabolic syndrome and the relationship with hypertension, obesity,
hypothyroidism and stress. Cardio vascular disorders and atherosclerosis-defining
the ailments that fall in this category, understanding the factors that contribute to the
syndrome. Irritable bowel syndrome- influence of diet, stress and environment on the
condition.
RECOMMENDED BOOKS
1. Textbook of Biochemistry with Clinical Correlations (2011) Devlin, T.M. John Wiley
& Sons, Inc. (New York), ISBN: 978-0-4710-28173-4.
3. The World of the cell, 7th edition (2009) 4. Genetics (2012) Snustad and
Simmons,
5. Cooper, G.M. and Hausman, R.E. 2009 The Cell: A Molecular Approach. 5th
edition. ASM Press & Sunderland, Washington, D.C.; Sinauer Associates, MA.
Department of Biochemistry
Faculty of Life Sciences
AMU, Aligarh
B.Sc. (Hons) Syllabus
(Effective from 2015-16)
Passed in BOS held on 26.10.2015
BIOCHEMISTRY
B.Sc. (Hons) Final year
Semester VI
Core Course VII
MOLECULAR BIOLOGY
Credits: 4
Total Lectures: 48
NOTE: The course will be evaluated out of 100 marks and will have the following
components of evaluation: Sessional for 10 marks, mid-semester examination of one
hour duration for 30 marks, end-semester examination of two hours for 60 marks.
RECOMMENDED BOOKS
BIOCHEMISTRY
B.Sc. (Hons) Final year
Semester VI
Core Course VIII
CONCEPTS IN GENETICS
Credits: 4
Total Lectures: 48
NOTE: The course will be evaluated out of 100 marks and will have the following
components of evaluation: Sessional for 10 marks, mid-semester examination of one
hour duration for 30 marks, end-semester examination of two hours for 60 marks.
Allelic variation and gene function - dominance relationships, multiple alleles, lethal
alleles and null alleles. Pleiotropy gene interaction - epistatic and non epistatic.
Penetrance and expressivity. Hardy-Weinberg principle and its applications.
1. Genetics (2012) 6th ed., Snustad, D.P. and Simmons, M.J., John Wiley & Sons.
(Singapore), ISBN: 978-1-118-09242-2.
2. Genetics - A Conceptual Approach (2012), 4th ed., Pierce, B.A., W.H. Freeman &
Co. (New York), ISBN:13:978-1-4292-7606-1 / ISBN:10:1-4292-7606-1.
BIOCHEMISTRY
B.Sc. (Hons) Final year
Semester VI
Elective Discipline Centric Course
NUTRITIONAL BIOCHEMISTRY
Credits: 4
Total Lectures: 48
NOTE: The course will be evaluated out of 100 marks and will have the following
components of evaluation: Sessional for 10 marks, mid-semester examination of one
hour duration for 30 marks, end-semester examination of two hours for 60 marks.
Review of functions of proteins in the body, Digestion and absorption. Essential and
nonessential amino acids. Amino acid availability antagonism, Toxicity and
imbalance, Amino acid supplementation. Effects of deficiency. Food source and RDA
for different age group. Amino acid pool. NPU, Biological value , Nitrogen balance.
PEM and Kwashiorkor.
RECOMMENDED BOOKS
1. Textbook of Biochemistry with Clinical Correlations (2011) Devlin, T.M. John Wiley
& Sons, Inc. (New York), ISBN: 978-0-4710-28173-4.
4. The vitamins, Fundamental aspects in Nutrition and Health (2008); G.F. Coombs
Jr. Elsevier’s Publications. ISBN-13- 978-0-12- 183493-7.
BIOCHEMISTRY
B.Sc. (Hons) Final year
Semester VI
Elective Discipline Centric Course
NOTE: The course will be evaluated out of 100 marks and will have the following
components of evaluation: Sessional for 10 marks, mid-semester examination of one
hour duration for 30 marks, end-semester examination of two hours for 60 marks.
BIOCHEMISTRY
B.Sc. (Hons) Final year
Semester VI
Elective Discipline Centric Course
NOTE: The course will be evaluated out of 100 marks and will have the following
components of evaluation: Sessional for 10 marks, mid-semester examination of one
hour duration for 30 marks, end-semester examination of two hours for 60 marks.
Bacteria, viruses, protozoa and fungi. Past and present emerging and re-emerging
infectious diseases and pathogens. Source, reservoir and transmission of
pathogens, Antigenic shift and antigenic drift. Overview of viral and bacterial
pathogenesis. Infection and evasion.
Detailed study of malaria, history, causative agents, vectors, life cycle, Host parasite
interactions, Diagnostics, drugs and Inhibitors, resistance, vaccine development.
Other diseases including leishmaniasis, amoebiasis.
Fungal diseases, general characteristics. Medical importance of major groups,
pathogenesis,treatment.
RECOMMENDED BOOKS
1. Prescott, Harley, Klein's Microbiology (2008) 7th Ed., Willey, J.M., Sherwood,
L.M., Woolverton, C.J. Mc Graw Hill International Edition (New York) ISBN: 978-007-
126727. 44
2. Mandell, Douglas and Bennett.S, Principles and practices of Infectious diseases,
7th edition, Volume, 2. Churchill Livingstone Elsevier.