Mindanao State University – Iligan Institute of Technology Student: SALIMBAGAT, CHRISTINE.

P Section: 262

PHARMACOLOGY

DRUG STUDY

Brand Name: Cleocin Generic Name: Clindamycin hydrochloride Drug Classification: Lincosamides
Dosage, Route & Frequency Drug-Drug &
Side Effects
Prescrib Drug Action Drug-Food Indications Contraindications Adverse Reactions (By System)
Recommended (By System)
ed Interactions
Moderate to Severe Infections Semisynthetic Drug: Chlora Serious History of GI: nausea, Body as a Whole: Fever, serum sickness,
Adult: PO 150–450 mg derivative of mphenicol, e infections hypersensitivity to vomiting, stomach sensitization, swelling of face (following
q6h IM/IV 300–900 mg q6–8h lincomycin with a rythromycin when less clindamycin or pain topical use), generalized myalgia,
(max: 2700 mg/d) greater degree of possibly are toxic lincomycin; history Skin: mild skin rash superinfections, proctitis, vaginitis, pain,
Child: PO 10–30 mg/kg/d q6– antibacterial activity mutually alternatives of regional enteritis, Urogenital: vaginal induration, sterile abscess (following IM
8h. IM/IV 25–40 mg/kg/d q6–8h in vitro, better antagonistic are ulcerative colitis, or itching or discharge injections); thrombophlebitis (IV infusion).
Neonate: IM/IV = 7 d: 10–15 absorption, and to inappropriat antibiotic-associated CV: Hypotension (following IM), cardiac
mg/kg/d divided q8–12h; >7 d: lower incidence of GI clindamycin; e. Topical colitis; pregnancy arrest (rapid IV).
10–20 mg/kg/d divided q6–12h adverse effects than neuromuscul applications (category B), GI: Diarrhea, abdominal pain, flatulence,
Acne Vulgaris lincomycin. ar blocking are used in lactation. bloating, nausea,
Adult: Topical Apply to affected Suppresses protein action treatment of Cautious Use: vomiting, pseudomembranous colitis;
areas b.i.d.; 1% foam qd synthesis by binding enhanced acne vulgaris. History of GI esophageal irritation, loss of taste,
application to 50 S subunits of by NEUROM Vaginal disease, renal or medicinal taste (high IV doses), jaundice,
Bacterial Vaginosis bacterial ribosomes, USCULAR applications hepatic disease; abnormal liver function tests.
Adult: Topical Insert 1 and, therefore, BLOCKING are used in atopic individuals Hematologic: Leukopenia,
suppository intravaginally at inhibits other AGENTS (atra treatment of (history of eczema, eosinophilia, agranulocytosis,
bedtime times 3 d, or insert 1 antibiotics (e.g., curium, tubo bacterial asthma, hay fever); thrombocytopenia.
applicator full of cream erythromycin) that curarine, pan vaginosis in older patients >60 y. Skin: Skin rashes, urticaria, pruritus,
intravaginally at bedtime times 7 act at this site. curonium). nonpregnant dryness, contact dermatitis, gram-negative
d women. folliculitis, irritation, oily skin.
Responsibilities in the Nursing Process (ADPIE) Responsibilities in the Nursing Process (ADPIE)
A - Assess for infection. Obtain specimens for culture and sensitivity prior to initiating therapy. MAR.
Monitor bowel elimination. Assess patient for hypersensitivity Provide patient education as necessary.
D - Risk for infection (Indications, Side Effects) I - First dose may be given before receiving results. Do not confuse Clindesse with Clindets. ● PO: Administer with a
Diarrhea (Side Effects) full glass of water. May be given with or without meals. Shake liquid preparations well. Do not refrigerate. Stable
P - Plan medication administration to avoid disruption. for 14 days at room temperature. ● IM: Do not administer 600 mg in a single IM injection
Prepare medications for ONE patient at a time. Check expiration date. E - Resolution of the signs and symptoms of infection. Length of time for complete resolution depends on the
Follow the SEVEN RIGHTS of medication preparation. organism and site of infection. ● Endocarditis prophylaxis. ● Improvement in acne vulgaris lesions. Improvement
Complete necessary focused assessments, lab values, and/or vital signs, and document on should be seen in 6 wk but may take 8–12 wk for maximum benefit.