AC Analytical Controls BV

Sample Name: UOP868 Calibration standard

Version 1.0
Effective Date: September 30, 2013
Regulation: 1907/2006/EC

Material Safety Data Sheet

1 IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE

COMPANY/UNDERTAKING
1.1 Product Identifier
Material Name : UOP868 Calibration standard
AC Sample No. : 00.02.710
1.2 Relevant identified uses of the substance or mixture and uses advised against
Product Use : Laboratory use only
1.3 Details of the supplier of the substance or mixture
Manufacturer/Supplier : AC Analytical Controls BV
Innsbruckweg 35
3047 AG ROTTERDAM
Netherlands
Telephone : +31 (0)10-4624811
Email Contact for MSDS : safety.netherlands@paclp.com
1.4 Emergency Telephone Number
Between 08.00-18.00u : +31 (0)10-2456207

2 HAZARDS IDENTIFICATION
2.1 Classification of substances or mixture
Regulation (EC) No 1272/2008
Hazard classes / Hazard categories
Flammable liquids, 2 H225
Reproductive toxicity, 2 H361d
Aspiration toxicity, 1 H304
STOT RE, 2 H373
Skin irritation, 2 H315
STOT SE, 3 H336
2.2 Label Elements
Labeling according to Regulation (EC) No 1272/2008

Symbol(s) :

Signal Words : Danger

CLP Hazard Statements

PHYSICAL HAZARDS
H225 Highly Flammable liquid and vapour

HEALTH HAZARDS
H304 May be fatal if swallowed and enters airways
H315 Causes skin irritation
H336 May cause drowsiness or dizziness
H361d Suspected of damaging the unborn child
H373 Causes damage to organs through prolonged or repeated exposure

ENVIRONMENTAL HAZARDS
-

CLP Precautionary statements

Prevention : P210; P261; P281

Response : P301+P310; P331

Storage : -

Disposal : -

Page 1 of 8 MSDS-00.02.710
 AC Analytical Controls BV
Sample Name: UOP868 Calibration standard

Version 1.0
Effective Date: September 30, 2013
Regulation: 1907/2006/EC

2.3 Other Hazards

Other information : none

3 COMPOSITION/INFORMATION ON INGREDIENTS
3.2 Mixtures
Preparation Description : solution in Toluene

Hazardous Components
Classification of components according to Regulation (EC) No 1272/2008

Chemical Name CAS No. EINECS REACH Registration No. Conc.

(%)
Toluene 108-88-3 203-625-9 601-021-00-3 72
Decane 124-18-5 204-686-4 4
Butylcyclohexane 1678-93-9 216-837-1 5
Nonane 111-84-2 203-913-4 - 5
Propylcyclohexane 1678-92-8 216-836-6 3
Octane 111-65-9 203-892-1 601-009-00-8 3
Ethylcyclohexane 1678-91-7 216-835-0 2
Heptane 142-82-5 205-563-8 601-008-00-2 2
methylcyclohexane 108-87-2 203-624-3 601-018-00-7 2
n-Hexane 110-54-3 203-777-6 601-037-00-0 1
Cyclohexane 110-82-7 203-806-2 601-017-00-1 1

Chemical Name Hazard Class & Category Hazard Statement

Toluene Flam. Liq. 2; Repr. Tox. 2; Asp. H225; H304; H315; H336; H361d;
Tox. 1; STOT RE 2; Skin Irrit. 2; H373
STOT SE 3
Decane Flam. Liq. 3; Asp. Tox. 1 H226; H304
Butylcyclohexane Flam. Liq. 3 H226
Nonane Flam. Liq. 3; Acute Tox., H226; H304; H315; H319; H332;
Inhalation, 4; Skin Irrit., 2; Eye H336
Irrit. 2; STOT-SE 3; Asp. Tox. 1
Propylcyclohexane Flam. Liq. 3 H226
Octane Flam. Liq. 2; Asp. Tox. 1; Skin H225, H304, H315, H336, H410
Irrit. 2; STOT SE 3; Aquatic Acute
1; Aquatic Chronic 1;
Ethylcyclohexane Flam. Liq. 2; Asp. Tox. 1; H225, H304
Heptane Flam. Liq. 2; Asp. Tox. 1; Skin H225, H304, H315, H336, H410
Irrit. 2; STOT SE 3; Aquatic Acute
1; Aquatic Chronic 1;
methylcyclohexane Flam. Liq. 2; Asp. Tox. 1; Skin H225, H315, H304, H336, H411
Irrit. 2; STOT SE 3; Aquatic
Chronic 2;
n-Hexane Flam. Liq. 2; Repr. 2; Asp. Tox. 1; H225; H304; H315; H336; H361f;
STOT RE 2; Skin Irrit. 2; STOT H373; H411
SE 3; Aquatic Chronic 2
Cyclohexane Flam. Liq. 2; Asp. Tox. 1; Skin H225; H304; H315; H336; H410
Irrit. 2; STOT-SE 3; Acute Aqua
Tox. 1; Chronic Aqua Tox. 1

Page 2 of 8 MSDS-00.02.710
 AC Analytical Controls BV
Sample Name: UOP868 Calibration standard

Version 1.0
Effective Date: September 30, 2013
Regulation: 1907/2006/EC

4 FIRST AID MEASURES

4.1 Description of First Aid Measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.

Inhalation : Remove to fresh air. If rapid recovery does not occur,

transport to nearest medical facility for additional
treatment.
Skin Contact : Wash with soap and water. Consult a physician.
Eye Contact : Flush eye with copious quantities of water. Consult a
physician.
Ingestion : If swallowed, do not induce vomiting; transport to
nearest medical facility for additional treatment.
4.2 Most important symptoms/effects, acute & delayed
Lung irritation, chest pain, pulmonary edema, inhalation studies on toluene have
demonstrated the development of inflammatory and ulcerous lesions of the penis, prepuce,
and scrotum in animals.
4.3 Indication of immediate medical attention and special treatment needed
No data available

5 FIRE FIGHTING MEASURES

Clear fire area of all non-emergency personnel.
5.1 Extinguishing Media
Foam, water spray or fog. Dry chemical powder, carbon dioxide.
5.2 Special hazards arising from substance or mixture
Carbon oxides
5.3 Advice for fire-fighters
Wear full protective clothing and self-contained breathing apparatus.

Additional Advice:
Keep adjacent containers cool by spraying with water.

6 ACCIDENTAL RELEASE MEASURES

Avoid contact with spilled or released material. For guidance on selection of personal
protective equipment see Chapter 8 of this Material Safety Data Sheet. See Chapter 13 for
information on disposal. Observe the relevant local and international regulations. Evacuate the
area of all non-essential personnel. Ventilate contaminated area thoroughly.
6.1 Personal precautions, Protective Equipment and Emergency Procedures
Use personal protective equipment. Do not breathe fumes, vapour. Ensure adequate
ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of
vapours accumulating to form explosive concentrations. Vapours can accumulate in low
areas.
6.2 Environmental Precautions
Shut off leaks, if possible without personal risks. Remove all possible sources of ignition in
the surrounding area. Prevent from spreading or entering drains, ditches or rivers.
6.3 Methods and material for Containment and Clean Up
Collect spillage with an electrically protected vacuum cleaner or wet-brushing in to a labeled,
sealable container for product recovery or safe disposal. Allow residues to evaporate or soak
up with an appropriate absorbent material and dispose of safely. Remove contaminated soil
and dispose of safely. Shovel into a suitable clearly marked container for disposal or
reclamation in accordance with local regulations.

Page 3 of 8 MSDS-00.02.710
 AC Analytical Controls BV
Sample Name: UOP868 Calibration standard

Version 1.0
Effective Date: September 30, 2013
Regulation: 1907/2006/EC

7 HANDLING AND STORAGE

General Precautions:
Avoid breathing vapours or contact with material. Only use in well ventilated areas. Wash
thoroughly after handling. For guidance on selection of personal protective equipment see
Chapter 8 of this Material Safety data Sheet. Use the information in this data sheet as input to
a risk assessment of local circumstances to help determine appropriate controls for safe
handling, storage and disposal of this material. Air-dry contaminated clothing in a well-
ventilated area before laundering. Properly dispose of any contaminated rags or cleaning
materials in order to prevent fires. Prevent spillages. Use local exhaust ventilation if there is
risk of inhalation of vapours, mists or aerosols. Never siphon by mouth. Contaminated leather
articles including shoed cannot be decontaminated and should be destroyed to prevent reuse.
For comprehensive advice on handling, product transfer, storage and tank cleaning refer to
the product supplier.
7.1 Precautions for Safe Handling
Avoid contact with skin and eyes. Avoid inhaling vapour and/or mists. Electrostatic charges
may be generated during pumping. Electrostatic discharge may cause fire. Extinguish any
naked flames. Do not smoke. Remove ignition sources. Avoid sparks. Earth all equipment.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent
leakage.
7.3 Specific End Uses
No data available

8 EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1 Control Parameters
Occupational Exposure Limits

Component Exposure Application Value

Type Area
Toluene TWA Europe. Indicative 50 ppm
occupational 192 mg/m3
exposure limit value

STEL Europe. Indicative 100 ppm

occupational 384 mg/m3
exposure limit value
Identifies the possibility of significant uptake through the skinIndicativ
8.2 Exposure Controls
General Information:
Handle in accordance with good industrial hygiene and safety practice. Wash hands before
breaks and at the end of workday.

Personal Protective Equipment

Personal protective equipment (PPE) should meet recommended national standards. Check
with PPE suppliers.
Eye Protection : Face shield and safety glasses. Use equipment for eye
protection tested and approved under appropriate
government standards such as NIOSH (US) or EN 166
(EU)
Hand Protection : Handle with gloves. Gloves must be inspected prior to
use. Use proper glove removal technique (without
touching glove’s outer surface) to avoid skin contact
with this product. Dispose of contaminated gloves after
use in accordance with applicable laws and good
laboratory practices. Wash and dry hands.
Body Protection : Complete suit protecting against chemicals, Flame
retardant antistatic protective clothing. The type of
protective equipment must be selected according to
the amount of the dangerous substance at the specific
workplace.

Page 4 of 8 MSDS-00.02.710
 AC Analytical Controls BV
Sample Name: UOP868 Calibration standard

Version 1.0
Effective Date: September 30, 2013
Regulation: 1907/2006/EC

Respiratory Protection : Where risk assessment shows air-purifying respirators

are appropriate use a full-face respirator with multi-
purpose combination (US) or type ABEK (EN 14387)
respirator cartridges as a backup to engineering
controls. If the respirator is the sole means of
protection, use a full-face supplied air respirator. Use
respirators and components tested and approved
under appropriate government standards such as
NIOSH (US) or CEN (EU).

9 PHYSICAL AND CHEMICAL PROPERTIES

9.1 Information on basic physical and chemical properties
Appearance : liquid
Color : colorless
Odor : no data available.
pH : no data available.
Initial Boiling Point and Boiling Range : 110-111 °C
Melting / freezing point : -93 °C
Pour point : no data available.
Flash point : 4,0 °C
Upper / lower Flammability or Explosion limits : 7-1,2 %(V)
Auto-ignition temperature : 535,0 °C
Vapour pressure : 29,1 hPa @ 20 °C
Water solubility : no data available.
Relative density : 0,865 g/mL @ 25 °C
Solubility in other solvents : no data available.
n-octanol/ water partition coefficient (log Pow) : no data available.
Kinematic viscosity : no data available.
Vapour density (air=1) : no data available.
9.2 Other information
Other information : no data available

10 STABILITY AND REACTIVITY

10.1 Reactivity : no data available
10.2 Chemical Stability : no data available
10.3 Possibility of Hazardous Reactions : no data available
10.4 Conditions to Avoid : Avoid heat, sparks, open flames
and other ignition sources.
Extremes of temperature and direct
sunlight.
10.5 Incompatible Materials : Strong oxidizing agents.
10.6 Hazardous Decomposition Products : no data available

11 TOXICOLOGICAL INFORMATION
11.1 Information on Toxicological effects
Acute Oral Toxicity : LD50-rat->5,580 mg/kg
Acute Dermal Toxicity : LD50-rabbit- 12,196 mg/kg
3
Acute Inhalation Toxicity : LC50-rat-12,500-28,800 mg/m
Skin Corrosion/Irritation : skin-rabbit-Skin irritation-24h
Serious Eye Damage/Irritation : no data available.
Aspiration Hazard : no data available.
Germ Cell Mutagenicity : Genotoxicity in vitro-rat-Liver
DNA damage
Carcinogenicity : 3-Group 3: Not classifiable as to its
carcinogenicity to humans
(Toluene).

Page 5 of 8 MSDS-00.02.710
 AC Analytical Controls BV
Sample Name: UOP868 Calibration standard

Version 1.0
Effective Date: September 30, 2013
Regulation: 1907/2006/EC

Reproductive and : Damage to fetus possible.

developmental Toxicity Suspected human reproductive
toxicant.
Reproductive toxicity-rat-inhalation
Paternal Effects: Spermatogenesis
(including genetic material, sperm
morphology, motility and count).
Experiments have shown
reproductive toxicity effects in male
and female laboratory animals.
Development Toxicity-rat-Oral
Effects on Embryo or Fetus:
Fetotoxicity (Except death, e.g.,
stunted fetus).
Specific target organ toxicity
– single exposure : no data available.
Specific target organ toxicity
– repeated exposure : no data available.

Signs and Symptoms of Exposure:

Lung irritation, chest pain, pulmonary edema. Inhalation studies on toluene demonstrated
the development of inflammatory and ulcerous lesions of the penis, prepuce, and scrotum in
animals.

Additional Information:
RTECS: XS5250000

12 ECOLOGICAL INFORMATION
Basis for Assessment : Information given is based on
knowledge of the main component
Toluene.
12.1 Toxicity
Acute Toxicity to fish : LC50-Lepomis macrochirus (Bluegill) – 74.00-340.00 mg/l-96h
LC50-Oncorhynchus mykiss (rainbow trout) – 7.63 mg/l-96h
NOEC-Pimephales promelas (fathead minnow) – 5.44 mg/l-7d
LOEC-Pimephales promelas (fathead minnow) – 8.04 mg/l-7d
Other Invertebrates : EC50-Daphnia magna (Water flea) – 8.00 mg/l-24h
Immobilization EC50-Daphnia magna (Water flea) – 6 mg/l- 48h
Algae : EC50-Chlorella vulgaris (Fresh water algae) – 245.00 mg/l-24h
EC50-Pseudokirchneriella subcapitata (green algae) – 10.00
mg/l-24h
12.2 Persistence and degradability : no data available
12.3 Bioaccumulative Potential : no data available
12.4 Mobility : no data available
12.5 Result of the PBT and vPvB assessment : no data available
12.6 Other Adverse Effects : Toxic to aquatic life.

13 DISPOSAL CONSIDERATIONS

13.1 Waste Treatment Methods

Product:
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra
care in igniting as this material is highly flammable. Offer surplus and non-recyclable
solutions to a licensed disposal company.

Contaminated packaging:
Dispose of as unused product

Page 6 of 8 MSDS-00.02.710
 AC Analytical Controls BV
Sample Name: UOP868 Calibration standard

Version 1.0
Effective Date: September 30, 2013
Regulation: 1907/2006/EC

14 TRANSPORT INFORMATION
2 2 1, 2
ADR/RID IMDG IATA
14.1 Un No. : 1294 1294 1294
14.2 Proper shipping name : TOLUENE TOLUENE Toluene
14.3 Transport Hazard Class : 3 3 3
14.4 Packing group : II II II
14.5 Environmental Hazard : no no no
14.6 Special Precautions : - - -
1
This sample can also be transported under UN3316, Chemical kits.
2
This sample can also be transported as non-restricted
See Chapter 16 for additional transport information.

15 REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006
15.1 Safety, health and environmental regulations/legislation specific for the substance or
mixture
Other regulatory Information
No data available
15.2 Chemical Safety Assessment
A Chemical Safety Assessment was performed for this substance.

16 OTHER INFORMATION
1
Additional transport information
AC Analytical Controls B.V. uses Special Provision A163 from IATA, Dangerous Goods
rd
Regulations, 53 Edition to classify and ship our samples as UN3316, Chemical Kit.

Special Provision A163:

Chemical kits….. containing dangerous goods in inner packaging’s which do not
exceed the quantity limits for excepted quantities to individual substances…..

Chemical kits
Boxes, cases, etc., containing small amounts of one or more compatible items of
dangerous goods used for analytical or other purpose.
2
Non-restricted dangerous goods in de Minimis Quantities
Assigned dangerous goods in de Minimis Quantities with the specific code are not subject
to Transport Regulations:
 as per 2.6.10.1 (IATA DGR) – By Air
 as per 3.5.1.4 (ADR) – By Road
 as per 3.5.1.4 (IMDG -Code) – By Sea
when carried as cargo provided that:
1. The maximum net quantity of material per inner packaging is limited to 1 mL for
liquids and gases and 1 g for solids.
2. The maximum net quantity of dangerous goods per outer packaging does not exceed
100 mL for liquids and gases or 100 g for solids.

Recommended Restrictions on Use

(Advice Against) : This product must be used in applications other than
Additional Information
those recommended in Section 1, without first seeking
the advice of the supplier. This product is not be used
as a solvent or cleaning agent; for lighting or
brightening fires; as a skin cleanser.
: This document contains important information to
ensure the safe storage, handling and use of this
product. The information in this document should be
brought to the attention of the person in your
organization responsible for advising on safety
matters.

Page 7 of 8 MSDS-00.02.710
 AC Analytical Controls BV
Sample Name: UOP868 Calibration standard

Version 1.0
Effective Date: September 30, 2013
Regulation: 1907/2006/EC

Other Information

Further Information : This product is intended for use in closed systems

only.

MSDS Distribution : The information in this document should be made

available to all who may handle the product.

MSDS Version Number : 1.0

MSDS Effective Date : September 30, 2013

MSDS Revisions : A vertical bar (│) in the left margin indicates an

amendment from the previous version.

MSDS Regulations : Regulation 1907/2006/EC

Disclaimer : This information is based on our current knowledge

and is intended to describe the product for the
purposes of health, safety and environmental
requirements only. It should not therefore be construed
as guaranteeing any specific property of the product.
Exposure scenarios are available on request.

Page 8 of 8 MSDS-00.02.710