LIPIDS LESSON LAYOUT

Chemical reactions of fatty acid: COMPLEX LIPIDS

1. Esterification 1. Lipoproteins
2. Acid hydrolysis Consists of:
3. Saponification Ø Core: Hydrophobic Lipids (TAG,
4. Reaction at the double bond: Cholesteryl Ester)
Ø Hydrogenation Ø Surface: Amphipathic proteins,
Ø Partial Hydrogenation Phospholipids, Cholesterol,
5. Oxidation Apolipoprotein
Ø Apolipoproteins
GLYCERIDES
2 classes of glycerides: Classification of lipoproteins based
1. Neutral glycerides on ultracentrifugation:
2. Phosphoglycerides Ø Chylomicrons
3. Fats Ø Very low density lipoprotein
4. Oil Ø Low density lipoprotein
5. Phospholipids Ø High density lipoprotein
Ø Phosphatidylcholine (Lecithin)
Ø Phosphatidylethanolamine
(Cephalin)
6. Phosphogylcerides
(Glycerophospholipids)
7. Sphingophospholipid
Ø Sphingomyelin
8. Sphingoglycolipid
Ø Cerebrosides:
Glucocerebroside
Galactocerebroside

NONGLYCERIDE LIPIDS
1. Steroids (Terpene)
Ø Cholesterol
2. Bile Salts
3. Steroid Hormones
4. Eicosanoids (Messenger lipids)
3 principal types of Eicosanoids:
Ø Prostaglandins
Ø Thromboxanes
Ø Leukotrienes
5. Biological waxes