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PHAR

4 LECTURE
1ST Semester SY 2019-2020


PRACTICE SET: ISOTONIC SOLUTIONS

1. How much Sodium chloride is required to render
a) 30.0 mL of a 1.0% solution of Apomorphine HCl isotonic with the blood serum
b) 2.0 fluidounces of 1.7% solution of Apomorphine HCl isotonic with the blood serum?
‘D’ 1% Apomorphine HCl = 0.08°C

2. Calculate the quantity of NaCl needed to render 50.0 mL of a 1.5% Boric acid solution isotonic with
the lachrymal fluid. ‘D’ 1% H3BO3 = 0.29°C

3. Calculate the Sodium chloride Equivalent ‘E’ of the following coumpounds.
a) Non-electrolytes
1) Antipyrine (MW: 188.2)
2) Chlorobutanol (MW: 177)
a) Electrolytes dissociating 80%
1) Boric acid (MW: 61.8) – very weak electrolyte
2) Phenacaine HCl (MW: 353); 2-ion
3) Pilocarpine nitrate (MW: 271); 2-ion
4) Zinc chloride (MW: 136)

4. How many grams of NaCl should be used in compounding the following prescription?
Rx
Pilocarpine nitrate 0.300 g
Sodium chloride q.s.
Purified water ad 30.0 mL
Make isotonic sol.
Sig. For the eye

5. How many milligrams of H3BO3 should be used in compounding the following prescription?
Rx
Phenacaine HCl 1.0%
Chlorobutanol ½%
H3BO3 q.s.
Purified water ad 60.0 mL
Make isotonic sol.
Sig. One drop in the eye

6. How much H3BO3 should be used in compounding the following prescription?
Rx ‘D’ 1% solution
Tetracaine HCl 0.33% 0.62°C
Zinc sulfate 0.17% 0.62°C
H3BO3 q.s.
Purified water ad 30.0 mL
Make isotonic sol.
Sig. One drop into each eye

7. A local ophthalmologist is treating one of his patients for a post-LASIK eye infection that is not
responding to topical ciprofloxacin. These infections, although rare, can occur after laser in situ
keratomileusis (LASIK) surgery for vision correction. The ophthalmologist prescribes 60 mL of a 2.5%
amikacin sulfate isotonic solution, 2 drops in the affected eye every 2 hours.

Amikacin sulfate USP (C22H43N5O13•2H2SO4), m.w., 781.76, is an aminoglycoside-type antibiotic
containing 3-ions.

a) Determine the weight in grams of amikacin sulfate needed to prepare the solution.
b) Calculate the sodium chloride equivalent (E value) for amikacin sulfate.
c) Calculate the amount of sodium chloride needed to make the prepared solution isotonic.
d) How many milliliters of 23.5% sodium chloride should be used to obtain the needed sodium chloride?