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Evidence-Based Guidelines and Scripting to Support Nurses in Sepsis


Recognition, Reporting, and Treatment

Article  in  Critical Care Nurse · April 2015

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Scripting Nurse Communication to


Improve Sepsis Care
Dawn Marie Drahnak
Marilyn Hravnak
Dianxu Ren
Alice J. Haines
Patricia Tuite

epsis is caused by overwhelm-

S ing immune response to


infection. Risk factors include
baseline immunocompetence of the
Providing nurses with current evidence to inform practice for treat-
ment of patients with sepsis, coupled with appropriate tools (elec-
tronic screening and scripting) for report of positive screens, forms
patient, presence of comorbid con- a strong foundation on which to build an interprofessional and
ditions, and patient age (Kleinpell &
Schorr, 2014). Severe sepsis can
organizational sepsis treatment program.
cause damage to and failure of mul-
tiple organ systems. In sepsis, chem-
icals released by the body to fight 24.0 per 10,000 patients, with in- screening, nurses must be familiar
infection trigger widespread inflam- hospital mortality of 15%-30%; with a patient’s sepsis risk factors
mation. Chemical mediators re- mortality associated with severe and predisposition for infection
leased through the sepsis response sepsis ranged even higher at 30%- (e.g., chronic disease, impaired
damage the endothelial lining of 60% (Hall, Williams, DeFrances, & immunocompetence), as well as
blood vessels and lead to increased Golosinskiy, 2011). A brief by Torio factors likely to contribute to organ
capillary leakage. Cytokine release and Andrews (2013) reported sepsis dysfunction (e.g., causative organ-
prompts production of adhesion resulted in an aggregate healthcare ism, genetic composition, preexist-
molecules on vascular endothelial cost of $20.3 billion in 2011. Hall ing organ dysfunction, timely ther-
cells and neutrophils, causing fur- and colleagues (2011) identified the apeutic intervention, extremes of
ther endothelial injury through estimated annual inpatient cost of age [infants and elderly]) (Angus &
release of the neutrophil compo- sepsis nationwide in 2008 as $14.6 van der Poll, 2013).
nents. Activated neutrophils release billion.
nitric oxide, a potent vasodilator Nurses play a vital role in early
that contributes to septic shock sepsis recognition and initiation of Literature Review
(Opal & van der Poll, 2015). These targeted treatment. Nurses’ ability A literature review (2009-2016)
events collectively can cause vasodi- to assess a patient’s vital signs and using keywords sepsis, evidence-
lation, hypotension, misdistribu- physical condition is key to early based practice, nurse-driven, sepsis
tion of blood flow, and hypoperfu- sepsis recognition (Kleinpell & screening, scripting, guidelines, and
sion and dysfunction. Sepsis severi- Schorr, 2014). For knowledgeable sepsis bundles was conducted using
ty and the time to sepsis recogni-
tion and treatment impact the like-
Dawn Marie Drahnak, DNP, RN, CCNS, CCRN, is Assistant Professor, University of Pittsburgh
lihood of mortality from organ dys-
function (Kleinpell & Schorr, 2014). at Johnstown, Johnstown, PA.
Marilyn Hravnak, PhD, RN, CRNP, BC, FCCM, FAAN, is Professor, University of Pittsburgh
Severe sepsis is a significant prob-
School of Nursing, Pittsburgh, PA.
lem, with an incidence of 300 to

Dianxu Ren, MD, PhD, is Associate Professor, University of Pittsburgh School of Nursing,
more than 1,000 cases per 100,000
Pittsburgh, PA.
persons annually in the United

Alice J. Haines, DNP, RN, CMSRN, is Assistant Professor, University of Pittsburgh School of
States (Gaieski, Edwards, Kallan, &

Nursing, Pittsburgh, PA.


Carr, 2013). For 2000-2008, the rate
of hospitalized patients with a prin-
Patricia Tuite, PhD, RN, CCNS, is Assistant Professor, University of Pittsburgh School of
Nursing, Pittsburgh, PA.
cipal diagnosis of septicemia or sep-
sis more than doubled from 11.6 to

July-August 2016 • Vol. 25/No. 4 233


CINAHL and Ovid MEDLINE. Early Within 6 hours, vasopressor treat- sample (n=71) of total patient med-
goal-directed therapy involving ment is initiated to control hypo- ical records (N=492) for July 2012-
fluid resuscitation and appropriate tension unresponsive to fluid resus- March 2013 revealed sepsis as one
antibiotic administration has been citation. Monitoring of central of the hospital’s top-10 diagnoses
reported to improve patient out- venous pressure, central venous (Diagnosis-Related Groups 870,
comes, including significantly de- oxygen saturation, and lactate val- 871, & 872). The audit found nurses
creased mortality (Angus et al., ues (if initially elevated) also is rec- were not completing the sepsis
2001; Gaieski et al., 2010). From the ommended (Dellinger et al., 2013). screen consistently (once per day
most recent studies (ProCESS, A nurse manager survey devel- recommended); adherence to IHI’s
ARISE, ProMISe), some clinicians oped by the American Association 3- and 6-hour bundles also was
agree early identification impacts of Critical-Care Nurses (AACN) inconsistent. When the sepsis
patient outcomes more than specif- focused on current practice for the screen was implemented in 2010,
ic goal-directed algorithms that fol- management of sepsis. More than process improvement follow up was
low initial treatment/resuscitation half of hospital respondents appear- not implemented to determine if
(Mouncey et al., 2015; The ARISE ed to have a systematic approach the screening tool was reliable, user-
Investigators and the ANZICS for the identification and screening friendly, or being used. Also, failure
Clinical Trials Group, 2014; The of patients with severe sepsis. Direct to develop supporting resources,
ProCESS Investigators, 2014). patient care providers (e.g., pulmo- such as nursing policy and physi-
One initiative to improve sepsis nologists, critical care physicians/ cian order sets, may have con-
care is the Surviving Sepsis Cam- nurses) were involved most com- tributed to nurses’ poor guideline
paign (Dellinger et al., 2013), which monly in process development and adherence. Nurse administrators
advocates systematic application of implementation (Durthaler, Ernst, called for action to improve patient
routine sepsis screening and early & Johnston, 2009). However, once care and nurses’ involvement in
patient treatment. This campaign procedures were developed, nurses SSC compliance.
was initiated in 2004 and updated reportedly had minimal responsibil- Overall goal of this project was to
in 2008 by the Society of Critical ity to identify patients with severe improve sepsis care by adopting the
Care Medicine; a third edition of sepsis. This trend remains true to SSC guidelines and IHI bundles,
evidence-based recommendations date; having nurses at the point of applying a nurse education inter-
was published in 2013 (Surviving care to implement sepsis bundles vention, and using an electronic
Sepsis Campaign [SSC], 2013) to based on current evidence may health record (EHR) sepsis screening
improve patient care and outcomes. result in less variability in screening and documentation tool.
Moore and co-authors (2009) and fewer missed opportunities for
reported a decrease in sepsis-related early diagnosis and treatment.
mortality from 35% to 23% The Third International Consen- Data Collection
through use of the guidelines for sus Definitions for Sepsis and Septic
early identification and treatment. Shock (Sepsis-3) (2016) provides Design
Although guidelines provide essen- updated definitions and clinical cri- A single-group pre-post survey
tial information, they do not ensure teria. This revision, the first since design was used to assess the impact
a local practice change (Kuehn, 2001, will replace previous defini- of education on nurses’ knowledge,
2013). tions, offer greater consistency for perception, and attitudes regarding
Care bundles from the Institute studies and clinical trials, and facili- sepsis and screening adherence. A
for Healthcare Improvement (IHI) tate earlier recognition and more chart audit was conducted to deter-
offer evidence-based interventions timely management of patients mine adherence to sepsis screening,
for defined patient populations and with sepsis or at risk of developing report, and treatment recommenda-
care settings to streamline guide- sepsis (Singer et al., 2016). tions according to the SSC 2012
lines into a set of actionable items guidelines before and after the
for use in a healthcare facility or nurse education was completed and
practice. Their use has had a pro- Improvement Needs/CQI an EHR tool was initiated. Permis-
found positive impact on patient Model sion to conduct the project was
outcomes (Resar, Griffin, Haraden, The Six Sigma quality improve- obtained from the institution’s Vice
& Nolan, 2012). Current sepsis bun- ment model DMAIC (Define, President of Patient Care Services.
dles provide screening protocols Measure, Analyze, Improve, and The project then was approved as a
and interventions for early treat- Control) was used to guide this quality improvement project by the
ment of sepsis at two time points (3 project (Pyzdek & Keller, 2010). institution’s Scientific Review Com-
and 6 hours). The 3-hour bundle As part of a gap analysis to deter- mittee of the Office of Research
includes blood cultures and meas- mine the state of sepsis care (using Administration.
urement of lactate values, with the new SSC 2012 3- and 6-hour
administration of broad-spectrum
Setting and Sample
bundle criteria), the investigator
antibiotics (within 1 hour) and flu- conducted a pre-intervention, retro- The project took place in a 648-
ids (30 ml/kg) for hypotension. spective chart review. A random bed Level 1 trauma hospital, part of

234 July-August 2016 • Vol. 25/No. 4


Scripting Nurse Communication to Improve Sepsis Care

FIGURE 1.
McKesson Horizon Expert Documentation™ Sepsis Screening Tool

Copyright © 2014 McKesson Corporation and/or one of its subsidiaries. All rights reserved. Used with permission.
Horizon Expert Documentation is a trademark of McKesson Corporation and/or one of its subsidiaries.

TABLE 1.
Sepsis Screening Criteria and Assessment

General Variables Inflammatory Variables


• Fever >38.3°C • White-cell count >12,000/mm3 or <4,000/mm3
• Hypothermia <36°C • Normal white-cell count with >10% immature forms
• Heart rate >90 beats per minute • Elevated plasma C-reactive protein
• Tachypnea • Elevated plasma procalcitonin
• Altered mental status
• Edema or positive fluid balance
• Hyperglycemia >120 mg/dl in the absence of diabetes

Hemodynamic Variables Organ-Dysfunction/Tissue-Perfusion Variables


• Systolic pressure <90 mm Hg • Partial pressure of arterial oxygen to the fraction of
• Mean arterial pressure <70 mm Hg inspired oxygen <300
• Elevated mixed venous oxygen saturation >70% • Urine output <0.5 ml/kg/hr or 45 ml/hr for at least 2 hours
• Elevated cardiac index • Serum creatinine >0.5 mg/dl
• Coagulation abnormalities
• Absence of bowel sounds
• Platelets <100,000/mm3
• Plasma total bilirubin >4 mg/dl
• Lactate >1 mmol/liter
• Decreased capillary refill or mottling

Source: Adapted from Dellinger et al. (2013)

a regional health system in central Nursing Practice Policy for Sepsis facilitate early recognition of sepsis
Pennsylvania. The sample included Screening and Reporting, with a (see Table 1). Nurses were instructed
681 nurses (60% of the facility’s requirement for screening all to report positive screens to the
acute care clinical nurses) who patients older than age 18 as part of healthcare provider and obtain
attended an annual clinical educa- the 8-hour nursing assessment (8:00 orders to implement the SSC’s 3-
tion session. a.m., 4:00 p.m., midnight) with the and 6-hour bundles. The policy also
McKesson Horizon Expert Docu- provided a script for nurses to
EHR Tool to Capture Sepsis mentation™ Sepsis Screening Tool report screening findings with use
Screening, Recognition, and (McKesson Techonology Solutions, of the ISBAR tool (Introduction,
Reporting Alpharetta, GA; see Figure 1). The Situation, Background, Assessment,
Education introduced nurses to screening criteria and nursing and Recommendation) to eliminate
the institution’s newly developed assessment for signs of infection communication barriers (AACN,

July-August 2016 • Vol. 25/No. 4 235


2013); use of the tool was practiced Institutional Adherence to McNemar’s test for paired data. All
and reinforced in the education Recommended Sepsis 10 knowledge questions demon-
intervention. Guidelines strated a statistically significant dif-
Sepsis screening adherence was ference between the pre- and post-
Educational Intervention for test (all p<0.001). For 9 of 10 ques-
Nurses to Increase concurrently audited (using the
Knowledge of Sepsis established policy at the time: sepsis tions, statistically significant im-
screening once each day of the provement was found in the per-
The primary author developed a centage of nurses who answered the
patient’s hospitalization at 8:00
voice-over slide presentation that item correctly in the post-test
a.m.). A point prevalence audit for
included review of sepsis pathophys- (improvement ranges for scores
nurses’ adherence with sepsis
iology, patient assessment (see Table increased by 7.28%-63.5%). One
screening was completed 1 month
1), risk factors, SSC guideline bun- question (“What is the first step in
after education via a report run
dles, documentation, and report of the initial management of the
from McKesson Horizon Expert
findings. An expert panel of the patient with sepsis?”) was answered
Documentation. Total patient cen-
institution’s Nurse Planning Com- correctly less frequently in the post-
sus (N=360) was analyzed and only
mittee and the manuscript authors test (-18.25% of nurses).
inpatients for 24 hours (n=178)
reviewed the presentation and made An audit to measure adherence to
were included. A comparison of the
recommendations for revision. After documentation of nursing sepsis
percentage of adherence to sepsis
three rounds of review and revision, screening post-education was con-
screening before and after educa-
consensus was achieved. Nurse par-
tion based on the established policy ducted. A comparison of adherence
ticipants completed a 5-minute sur-
at the time was conducted. to sepsis screening from the gap
vey before and after the 30-minute
analysis before education (once per
education, which concluded with a
day) and 1-month after intervention
role-playing case study to increase Results (three times per day) was completed.
nurses’ comfort with using the EHR
Demographic information col- The majority of all units experi-
sepsis tool and reporting positive
lected for nurses (N=680) who partic- enced a decrease in the percentage
findings to the provider. The module
ipated in the education revealed par- of patients for whom sepsis screen-
served as the sepsis competency for
ticipants were primarily young (ages ing never occurred. Although full
all nurses attending the annual edu-
19-29), Caucasian, and female. Most adherence to the protocol was not
cational session and now is viewed
nurses held diploma degrees and achieved post-education, the full
by new staff during hospital orienta-
were in the profession 0-5 years. adherence requirement increased
tion.
Results of the survey of nursing per- from screening once per 24 hours in
Nurses’ Perception and ception and attitudes before and the pre-phase to three times in 24
Attitude Concerning Sepsis after participating in the education- hours in the post-phase. Neverthe-
Awareness al process were favorable. The less, dichotomization of the results
Construction of the nurse assess- Wilcoxon Signed-Rank Test was as never screened or screened at least
ment tool followed the same pro- used to evaluate the Likert scale once in 24 hours (combining the cat-
cess of iterative expert panel review items. Nurses rated themselves as egories screened > never but < compli-
and revisions; four rounds were significantly more knowledgeable ant, and compliant combined) dem-
conducted before consensus was about sepsis after the education, sig- onstrated the number of patients
achieved. Pre-test included nurse nificantly more certain the hospital who never received the recom-
demographics (sex, age, education, has a consistent definition and mended screening decreased from
years since graduation, years on treatment for sepsis, an increased 40.6% to only 8.9% (see Figure 2),
project unit). Pre- and post-tests belief peers were aware of the differ- while the number who received at
included Likert-style items about ences in sepsis states, and increased least some screening increased from
nurse perceptions and attitudes comfort about their ability to recog- 59% to 91%. Further analysis of the
related to sepsis care (1=don’t know, nize sepsis and report it to a data using chi-square test demon-
5=strongly agree), and 10 items about provider (all p<0.0001). strated statistical significance in
nurses’ sepsis knowledge (1=very The pre- and post-nursing know- improved incidence of sepsis screen-
uncomfortable, 4=very comfortable). ledge scores are listed in Table 2. ing post-educational intervention
The last section assessed nurses’ Responses to multiple-choice know- (p<0.0001).
knowledge of sepsis pathophysiolo- ledge questions were dichotomized
gy and appropriate measures for as correct or incorrect, and the
identification, reporting, and treat- Statistical Analysis System (SAS) Limitations
ment of sepsis. Pre- and post-tools Version 9.3 (Cary, NC) PROC FREQ The voice-over slide presentation
were numbered to ensure linkage of program was conducted to compute ensured consistent delivery of edu-
each nurse’s survey responses, but tests and measures of association in cational material to the intended
no identifiable information was col- a 2 X 2 contingency table (Pre and audience, served as a future resource
lected. Post by Correct and Incorrect) using for new staff, and maximized nurs-

236 July-August 2016 • Vol. 25/No. 4


Scripting Nurse Communication to Improve Sepsis Care

TABLE 2.
Outcome Frequency Distribution* Pre and Post-Test Sepsis and Systemic Inflammatory
Response Syndrome (SIRS) Knowledge

Pre-Test Post-Test McNemar’s


Answered Correct Answered Correct Difference in % Test
Variable Frequency (%) Frequency (%) Pre- & Post-Test (p-value)
A lactate greater than __ mEq/L would N=660 N=672 +62.39 p<0.0001
warrant a critical value report. 205 (31.06) 628 (93.45)
Blood cultures should be obtained and the N=677 N=677 +9.16 p=0.0001
first antibiotics administered within how 345 (50.96) 407 (60.12)
many hours of diagnosis of sepsis?
How often should a patient be screened for N=667 N=677 +42.76 p<0.0001
sepsis? 298 (44.68) 592 (87.44)
Identification of the SIRS or a sepsis state N=674 N=676 +63.55 p<0.0001
case study (depicting patient with severe 129 (19.14) 559 (82.69)
sepsis)
Identification of the SIRS or a sepsis state N=674 N=677 +33.56 p<0.0001
case study (depicting patient with sepsis) 406 (60.24) 635 (93.80)
Identification of the SIRS or a sepsis state N=662 N=676 +83.04 p<0.0001
case study (depicting patient with SIRS) 317 (47.89) 658 (97.37)
What is the first step in the initial N=669 N=672 -18.25 p<0.0001
management of the patient with sepsis? 362 (54.11) 241 (35.86)
Severe sepsis may be manifested as (circle N=674 N=677 +34.40 p<0.0001
all that apply): 261 (38.72) 495 (73.12)
The initial sepsis resuscitation bundle in the N=598 N=675 +55.16 p<0.0001
adult patient with sepsis and hypotension 238 (39.80) 641 (94.96)
calls for a bolus of which amount and kind
of intravenous fluid?
Which of the vital signs are out of the N=658 N=675 +7.28 p<0.0001
normal range according to the SIRS 536 (81.46) 599 (88.74)
criteria?

ing resources. However, not having The same number of nurses did Nursing Implications
an expert consistently available for not complete both surveys, and some
Application of sepsis care bun-
questions and clarification may individuals did not complete every
have contributed to nurses answer- item (see Table 2). Although surveys dles has reduced mortality in hospi-
ing the “initial management” know- were distributed and collected sys- tals participating in the SSC, but the
ledge item incorrectly more often tematically, nurses were not moni- number of hospitals involved and
after intervention. Additionally, dif- tored for completion of surveys prior their adherence remain low (SSC,
ficulties in implementing the inter- to collection. However, differences 2013). Adoption of IHI bundles for
vention in different settings (emer- between groups and items were small sepsis care can be improved locally
gency department, acute care, and unlikely to bias results. In addi- through use of a nursing education
intensive care) have been recog- tion, authors did not determine if intervention and bundle compo-
nized. The study was limited to one improvements in sepsis care as illus- nents, coupled with a systematic
facility with acute care nurses and a trated by improved nurse knowledge method to screen for sepsis, recog-
post-intervention adherence meas- and adherence to sepsis screening nize screening findings, and com-
urement immediately after the resulted in decreased rates of sepsis municate them in a systematic
intervention. Finally, patient man- and sepsis mortality. A longer project manner.
agement with a focus on escalation time, collection, data specific to rates National Patient Safety Goals
or transition of care was not dis- of sepsis and sepsis outcome, and (NPSGs) focus on solving problems
cussed adequately and should be more advanced analysis and control in healthcare safety. The Joint
addressed in future education. for patient acuity would be needed Commission (2016) initially identi-
for this determination. fied effective communication as

July-August 2016 • Vol. 25/No. 4 237


FIGURE 2. screened, the screen was positive
Comparison of Non-Adherent, Partially Adherent, and Adherent and reported in a timely manner,
and treatment was implemented
according to SSC 2012 guidelines.
Pre Post
Many units have unique patient
100% needs and therefore perform nurs-
90% ing assessments and vital sign meas-
urements differently. A standard-
80%
69.1% ized approach to sepsis screening
70% may not be the answer. It may be
60% appropriate to examine similar
units, and collaborate with nurses
50% and other clinicians to determine
40.6% 40.6%
40% appropriate frequency and timing
for sepsis screening according to the
30%
18.5% 21.9% unit’s specific patient population.
20% Further study will be needed to
8.9% determine if patient outcomes are
10%
better with 8-hour vs. 12-hour
0 screening.
Non-Adherent Partially Adherent Adherent

Comparison of percentage of all hospitalized patients for whom staff were never
adherent to recommended sepsis screening, recognizing, and reporting or adherent
Conclusion
at least once in a 24-hour period before and after Surviving Sepsis Campaign guide-
Providing nurses with current
line adoption, nurse education, and use of the EHR sepsis screening and documen-
tation tool. Chi-square test demonstrated a statistical significance in improvement in
evidence to inform practice for

incidence of sepsis screening post-intervention (p<0.0001).


treatment of patients with sepsis,
coupled with appropriate tools
(electronic screening and scripting)
for report of positive screens, forms
a strong foundation on which to
one of its NPSGs and the 2016 ven to be a valid tool for the early build an interprofessional organiza-
update (“Get important test results identification of sepsis. Implemen- tional sepsis treatment program.
to the right staff person on time”) tation of the tool and a logic-based Education, communication script-
continues to address effective com- sepsis protocol decreased sepsis-relat- ing, nursing policy, and EHR
munication. The Situation-Back- ed mortality in one surgical inten- prompts can improve adoption of
ground-Assessment-Recommend- sive care by one-third (Moore et al., the IHI bundles and SCC 2012
ation (SBAR) process has been effec- 2009). Continued auditing for guidelines for sepsis care. Contin-
tive as a communication tool in screening adherence (every 8 hours) uous quality improvement efforts
acute care settings to structure high- with communication to nursing staff and auditing will position the
urgency conversation (Velji et al., on the degree of adherence must
organization to improve processes
2008). Increasing nurses’ knowl- continue. Real-time feedback will
and provide optimal patient out-
edge of sepsis and sepsis screening, allow nurses to improve aherence.
comes. Nevertheless, continued vig-
as well as providing them with the The project’s focus was screening
ilance and administrative support
SBAR approach, supports nurses in and reporting positive findings. Next
for this initiative will be needed to
communicating positive sepsis steps will include further education
enhance adherence and ensure suc-
screens to providers. to support recognition of tissue
cess.
Education and supportive nursing hypoperfusion and its treatment (6-
practice policy lead to more consis- hour bundle components) and use
tent use of the EHR sepsis screening of newly developed computerized REFERENCES
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238 July-August 2016 • Vol. 25/No. 4


Scripting Nurse Communication to Improve Sepsis Care

Instructions For Continuing Nursing Education Contact Hours


Scripting Nurse Communication to Improve Sepsis Care
Deadline for Submission: August 31, 2018 MSN J1612

The author(s), editor, editorial board, content reviewers,


and education director reported no actual or potential
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article and complete the evaluation through the AMSN Online education article.
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be printed. continuing nursing education by the American Nurses
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After completing this learning activity, the learner will be able to describe CEP 5387. Licensees in the state of California must retain
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