Beruflich Dokumente
Kultur Dokumente
BANGALORE – KARNATAKA
BY
DR. MADHUSHREE R.N.
DEPARTMENT OF MANASAROGA
S.D.M. COLLEGE OF AYURVEDA & HOSPITAL,
HASSAN -573201, KARNATAKA
GUIDE
DR. SUHAS KUMAR SHETTY
M.D. (Ay.),
ASSOCIATE PROFESSOR
DEPARTMENT OF MANASA ROGA
2012-2013
S. D. M. COLLEGE OF AYURVEDA & HOSPITAL,
HASSAN, KARNATAKA
FROM,
MADHUSHREE R.N.
Preliminary M.D. (Ay.) Scholar,
Department of Manasaroga
S.D.M. College of Ayurveda and Hospital,
HASSAN- 573201.
TO,
THE REGISTRAR,
Rajiv Gandhi University of Health Sciences Karnataka,
BANGALORE, Karnataka.
THROUGH,
The Principal and Head of the Dept. of Manasaroga,
S.D.M. College of Ayurveda and Hospital,
Hassan- 573201.
Subject: Submission of Completed Proforma for Registration of Synopsis of Dissertation.
Respected Sir,
I request you to kindly register the below mentioned subject against my name for the
submission of the dissertation to Rajiv Gandhi University of Health Sciences Karnataka,
Bangalore, for the partial fulfillment of M.D. (Ayurveda) in Manasaroga.
THE TITLE OF DISSERTATION:
ROLE OF PANCHAGAVYAGHRITA IN THE MANAGEMENT OF
ATATTVABHINIVESHA (OBSESSIVE COMPULSIVE DISORDER)
Herewith I am enclosing a completed Performa of synopsis for registration of subject for
Dissertation.
Thanking you,
Yours faithfully,
Place: Hassan
Date: 24/03/12 (DR.MADHUSHREE R.N.)
RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES
KARNATAKA, BANGALORE.
ANNEXURE
COMPLETED PROFORMA FOR REGISTRATION OF SUBJECT FOR
DISSERTATION.
In India prevalence rate of OCD is 0.9% among the psychiatric disorders. 4 The life
time prevalence of OCD in worldwide is estimated to be around 2.5% to 3.29%. The finding of
such high rates of OCD in epidemiological studies resulted in being labelled as “Hidden
Epidemic”. It is one of the 10th most disabling medical conditions worldwide. It is twice as
prevalent as schizophrenia and bipolar disorder.5 In Western countries OCD is the 4th most
common mental health condition after depression, substance abuse and phobias which affects
men, women and children.6 About 58-60% of the OCD patients experience two or more co-
morbid psychiatric condition during their lifetime. Available evidence suggests that OCD
patients report general impairment in their functioning in several areas particularly in marital,
occupational, emotional, social functioning.5 2.5% of global years are lost due to this disability.7
REVIEW OF LITREATURE:
Atattvabhinivesha is described as a Mahagada and its Nidana, Samprapti, Lakshana and
Chikitsa has been explained.9
Atattvabhinivesha is a Manasika Roga which is the cause for worldly distress.2
The clinical features like- Moodha, AlpaChetana, Vyakula have been commented thereby
providing an insight in understanding the disease.10
DRUG REVIEW:
By analysing the properties it is evident that Panchagavya Ghrita has its action on Buddhi,
Manas, Indriya and corrects the ManovahaSrotodusti. It purifies Rajas and Tamas. It acts on the
Sadhaka pitta , which is responsible for Dhee, Dhriti and Smriti by improving the nutrition to the
brain cells. Thus it acts as a Medhya Rasayana which helps in promotion of nutritional status of
nervous tissue thereby improving its function .A clinical study has shown that the effect of
Panchagavya Ghrita is highly significant on the Medha Guna.16 By analyzing the chemical
constituents also, milk and its products contain tryptophan-amino acid, which is responsible for
serotonin production. Vitamin E which is present in ghee reduces the oxidative stress produced in
OCD.17 Thus it combats the pathogenesis of Atattvabhinivesha(OCD).
6.3) PREVIOUS WORK DONE:
A) CLINICAL STUDY
7.1) SOURCE OF DATA:
20 Patients of Atattvabhinivesha (OCD) will be selected for study from the OPD and IPD
of SDM College of Ayurveda & Hospital, Hassan.
CRITERIA OF DIAGNOSIS:
For diagnosis detailed medical history and physical examinations will be done,
according to both Ayurvedic and Modern clinical methods. A detail interview will be conducted
to elucidate psychological problems, social problems and other areas of functioning.
The diagnostic guidelines mentioned in ICD-10 diagnostic criteria for obsessive
-compulsive disorder will be followed.18
1. Obsessional symptoms/compulsive acts or both must be present on most days for at least 2
successive weeks and be a source of distress /interference with activities.
2. Obsessional symptoms should have the following characteristics:
(a) They must be recognized as the individuals own thought/ impulses.
(b) There must be at least one thought /act that is still resisted unsuccessfully, even though others
may be present which the sufferers no longer resists.
(c) The thought of carrying out the act must not in itself be pleasurable (simple relief of
tension/anxiety is not regarded as pleasure in this sense)
(d) The thought, impulses or images must be unpleasantly repetitive.
To assess the psychological intactness, mental status examination and Manasika Bhava
Pareeksha will be carried out.
A. INCLUSION CRITERIA:
1. Patients are willing to sign the informed consent form.
2. Age group between 18-50 years of either sex.
B. EXCLUSION CRITERIA:
1. Organic brain disease
2. Schizophrenia, Dementia
3. Conversion disorder
4. Substance abuse
5. Uncontrolled diabetes and uncontrolled hypertension/tuberculosis
C. PLAN OF STUDY:
20 patients diagnosed as Atattvabhinivesha (OCD)will be selected from OPD and IPD of
SDM College Of Ayurveda And Hospital Hassan.
Yale Brown Obsessive Compulsive scale and Manasika Bhavas will be assessed before
and after treatment.
The scale will be assessed after 15 days of treatment and again after 1 month.
Panchagavya Ghrita will be given in the dosage of 6gm (melted) twice in a day with
warm water before food.19
Sl.No Sanskrit name English name Proportion
1 Goksheera Cow’s milk 1 part
2 Godadhi Cow’s curd 1 part
3 Gomootra Cow’s urine 1 part
4 Gomaya Cowdung 1 part
Swarasa
5 Goghrita Cow ghee 1 part
16-23=Moderate.
24-31=Severe.
32-40=Extreme.
Manasika Bhavas are assessed through Manasika Bhava Pareeksha scale 21before and after
treatment.
D. STATISTICAL ANALYSIS:
Statistical analysis of the results will be done by paired ‘t’ test .
DURATION OF STUDY: 1 month.
E. FOLLOW UP: Patients will be reviewed after 15 days of completion of treatment and
followed up to 1 month (extended if necessary)
INVESTIGATIONS:
REFERENCES:
3. Sadock BJ, Sadock VA. Obsessive Compulsive disorder. In: Kaplan and Sadock’s Synopsis
of Psychiatry. 10th ed. Philadelphia USA: Lippincott Williams and Wilkins ; 2007. p 604
4. Reddy YJ, Rao NP, Khanna S. An overview of Indian Research in Obsessive Compulsive
Disorder. Indian Journal of Psychiatry. 2010; 52: 200-209.
5. Gururaj GP, Badamath S, Reddy JYS, Chandrashekar CR . Family Burden, Quality of life and
disability in OCD : An Indian persepective. Journal of Post graduate Medicine.2008; 54 (e.g.2) :
91-97.
6. Sayegh SEL, Scott BEA, Angele Agelopoulous. Obsessive Compulsive Disorder: Unearthing
a hidden problem. Cleveland Clinic Journal of Medicine. 2003; 70: 10.
7. Jose Luis Ayuso-Mateos. Global Burden of OCD in 2000. Global programme on evidence for
health policy.21-08-2006; WHO Draft.
8. Sharma RK and Bhagwan Das Apasmara Chikitsa. In: Charaka Samhitha with Ayurveda
Deepika commentary of Chakrapanidatta. Reprint ed. Varanasi : Chowkamba Sanskrit series ;
2003: vol iii. p 453.
9. Sharma RK and Bhagwan Das. Apasmara Chikitsa. In: Charaka Samhitha with Ayurveda
Deepika commentary of Chakrapanidatta. Reprint ed. Varanasi : Chowkamba Sanskrit series ;
2003: vol iii. p 455
10. Gupta NS and Gupta BS. Apasmara Chikitsa. In: Charaka Samhitha with Jalpakalpataru
commentary of Gangadhara. 1st ed. Varanasi : Choukamba Sanskrit series ; vol iv. p 2756
11. Lavekar GS. Inventory of animal products used in Ayurvedic, Siddha and Unani-Part I. ed.
Delhi : Central Council for Research in Ayurveda and Siddha ; 2008. p 44.
12 . Lavekar GS. Inventory of animal products used in Ayurvedic, Siddha and Unani-Part I.
ed. Delhi : Central Council for Research in Ayurveda and Siddha ; 2008. p 59
13. Lavekar GS. Inventory of animal products used in Ayurvedic, Siddha and Unani-Part I. ed.
Delhi : Central Council for Research in Ayurveda and Siddha ; 2008. p 78
14. Lavekar GS. Inventory of animal products used in Ayurvedic, Siddha and Unani-Part I. ed.
Delhi : Central Council for Research in Ayurveda and Siddha ; 2008. p 86.
15. Lavekar GS. Inventory of animal products used in Ayurvedic, Siddha and Unani-Part I. ed.
Delhi : Central Council for Research in Ayurveda and Siddha ; 2008. p 54
16. Parma N, Vyer M, Vyer H. Critical study of Jara(ageing) and its management. Ayu Journal.
2012; 2: vol.33.p.264-269.
17. Lakhan SE and Vieria KF. Nutritional therapies for mental disorder. Nutritional Journal.1999.
18. ICD-10. Classification of Mental and Behavioural Disorder. In : (eds.) Clinical description
and diagnostic guidelines. 10th ed. Geneva: WHO; 1993.vol.1.
19. The Ayurvedic Formulary of India- Part I. 2 nd ed. Delhi. The Controller of Publications
Civil lines ; 2003. p 90.
20. Goodman WK, Price LH, Rasmussen SA, et al. The Yale-Brown Obsessive Compulsive
Scale. Development, use and reliability. Arch Gen Psychiatry. 1986; 46: 1006-1011.
21. Charaka, Dridhabala. Trividha roga vijnaneeyam vimanam. In. Acharya JT, The Charaka
samhita of Agnivesa with the Ayurveda dipika commentary by Chakrapani data. 5 th ed. Varanasi;
Chaukhambha Orientalia. 1995. P.248
9. SIGNATURE OF CANDIDATE :
10. REMARKS OF GUIDE :
11. NAME AND DESIGNATION OF GUIDE :