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CLEFT LIP AND

PALATE

Presented by:
Khushbu Agrawal
Dept of Orthodontics
CONTENTS
 Introduction
 Incidence
 Embryology
 Aetiology
 Predisposing factors
 Classification
 Diagnosis
 Problems associated with clefts
 Syndromes associated with clefts

2
 Management of Cleft lip and palate
• Timing of treatment sequence
• Presurgical Orthopedic treatment
• Nasoalveolar molding
• Alveolar Bone grafting
• Role of Orthodontist
• Orthognathic surgery
• Prosthetic rehabilitation
• Recent advances
• Other specialities
 Conclusion
 References
3
INTRODUCTION

• Cleft lip and palate is the second most


common congenital anamoly after clubfoot

• Amoung the 15 types of orofacial clefting,


cleft lip and palate is the most common one.

4
• Hippocrates (400 BC) and Galen (150 AD) mention cleft lip, but not
cleft palate in their writings

• Cleft palate – Fanco (1556)

• Repair of cleft lip – as early as 255-206 BC in China

• The first successful closure of a soft palate defect was reported in


1764 by LeMonnier, a French dentist.

5
Kingsley (1880)
- oral deformities as a branch of mechanical surgery

Calvin case (1921)


- a practical treatise on technique and principles of dental
orthopaedic and prosthetic correction of cleft palate

H.K.Cooper,Sr (1930’s)
- Introduced the integrated team concept and formed the Lanchester
cleft palate clinic
- True integration starts with a meeting of the minds of the individuals
who first examine the patient together and then agree on a program
together
6
INCIDENCE
INCIDENCE
• Worldwide one in 600 (1:600)

• cleft lip with or without the cleft palate 9.92/10,000

• cleft lip 3.28/10,000, and cleft lip and palate 6.64/10,000

• Birth prevalence of clefts between 27,000 and 33,000 clefts per year

A child is born with a cleft somewhere in the world every 2 minutes


according to a WHO study published in 2001

Reddy S et al. Incidence of cleft Lip and palate in the state of Andhra Pradesh, South India. Indian J Plast Surg. 2010 Jul-Dec; 43(2): 184–189.
• Caucasian population, the prevalence of CL was 25%, CLP 50%,
and CP 25%

• In India meta-analysis of 25 early studies from 1960 to 1979 showed


incidence of CLP 1.08 and CL 0.23 in 100 live births

• In India alone the number of infants born every year with CLP is
28,600

78 affected infants are born every day, or 3 infants with clefts born
every hour
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Reddy S et al. Incidence of cleft Lip and palate in the state of Andhra Pradesh, South India. Indian J Plast Surg. 2010 Jul-Dec; 43(2): 184–189.
• More common clefts are –
• Unilateral clefts

• Males female ratio is 2:1

• Left sided

• Males more affected by cleft lip

• Females more affected by cleft palate

10

Reddy S et al. Incidence of cleft Lip and palate in the state of Andhra Pradesh, South India. Indian J Plast Surg. 2010 Jul-Dec; 43(2): 184–189.
EMBRYOLOGY
EMBRYOLOGY
• Development of facial structures starts at the end of 4th week

• 5 facial prominences around stomatodeum


1. Unpaired frontonasal process

2. Paireed maxillary prominences

3. Paired mandibular prominences

12

Thronton JB, Nimer S and Howrd P. The incidence, classification, etiology and embryology of oral clefts. Semin Orthod 1996;2:162-168
• In following 2 weeks –
• The 2 medial nasal processes fuse in midline – upper lip

• Mandibular processes fuse in midline – lower lip

13

Thronton JB, Nimer S and Howrd P. The incidence, classification, etiology and embryology of oral clefts. Semin Orthod 1996;2:162-168
• The maxillary and lateral nasal process separated by nasolacrimal
groove/duct

• Frontonasal process – bridge of the nose

• Medial nasal process – tip of nose and philtrum of upper lip

• Lateral nasal process – ala of the nose

14

Thronton JB, Nimer S and Howrd P. The incidence, classification, etiology and embryology of oral clefts. Semin Orthod 1996;2:162-168
• Primary palate – maxillary and medial nasal process merge

• Formation of intermaxillary segment from merged medial nasal


prominences

15

Thronton JB, Nimer S and Howrd P. The incidence, classification, etiology and embryology of oral clefts. Semin Orthod 1996;2:162-168
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Thronton JB, Nimer S and Howrd P. The incidence, classification, etiology and embryology of oral clefts. Semin Orthod 1996;2:162-168
• Secondary palate – formed from 2 outgrowths from maxillary
prominences – palatine shelves

• Fuse in midline at 7th week

• Incisive foramen – midline landmark between primary and secondary


palate

17

Thronton JB, Nimer S and Howrd P. The incidence, classification, etiology and embryology of oral clefts. Semin Orthod 1996;2:162-168
Formation of clefts

• Failure of fusion of maxillary and medial nasal processes – anterior


to incisive foramen

• Failure of fusion of palatine shelves – posterior to incisive foramen

• Cleft lip – failure of proliferation of mesodermal cells in midline

18

Thronton JB, Nimer S and Howrd P. The incidence, classification, etiology and embryology of oral clefts. Semin Orthod 1996;2:162-168
Formation of clefts

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ETIOLOGY
AETIOLOGY
Ancient Folk explanations
• Aztecs – eclipses occurred because a bite had been taken
out of the moon

• Prevented with an obsidian knife above the pregnant


abdomen

• Modern Mexico prevented with keys and safety pins

22
Early Chinese
• Eating rabbit “hare lip”
• Bad karma or wrong doings

Philippines
• Force to the fetal face

Familial or “In the blood”

23
Genetic
Environ
mental
Multi
factorial
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1] Genetic

• Genetic disorders are classified into 4 groups


1. Chromosomal

2. Single gene

3. Multifactorial – oral clefts

4. Mitochondrial

25

John B. Thornton, Sue Nim Paul S. Howard. The incidence, classification, etiology and embryology of oral clefts. Semin Orthod 1996;2:162-168
2] Multifactorial because:

1) Chances increases if more than one family member if affected

2) More the severity, greater the chances of recurrence in sibling

3) Higher risk if affected individual is of less affected sex

4) Risk decreases in remotely related individuals

5) Consanguinity increases the rate because of sharing of genes

26

John B. Thornton, Sue Nim Paul S. Howard. The incidence, classification, etiology and embryology of oral clefts. Semin Orthod 1996;2:162-168
2 unaffected parents with 1 child affected
 Risk for future children:
 4.4% for CL+/-palate
 2.5% for CP only
1 parent affected
 Risk for future children
 3.2% for CL+/-palate
 6.8% for CP only
1 parent affected with 1 child affected
 Risk for future children
 15.8% for CL+/-palate
 14.9% for CP only

27
3] Environmental factors

• Maternal smoking or tobacco exposure

• Viral infections

• Poor nutrition

• Certain Medicinal drugs

• Teratogens like:
 Rubella virus, Cortisone/ steroids, Mercaptopurine,

Methotrexate, Valium, Dilantin

28

Peter Mosby et al. Cleft Lip and Palate. Lancet 2009; 374: 1773–85
PREDISPOSING FACTORS
 High maternal age
 Diabetes
 Toxemia
 Reduced blood supply
 Folic acid deficiency
 Racial – mongoloids
 Radiations

29

Peter Mosby et al. Cleft Lip and Palate. Lancet 2009; 374: 1773–85
CLASSIFICATION
CLASSIFICATION
Bixler divided oral clefts into three groups

1. Syndromic / single-gene / chromosomal or environmental


 1% of CLP AND 8% of isolated cleft palate

2. Familial
 25% of CLP and 12% of isolated cleft palate

3. Isolated / non-familial
 75% of CLP and 80% of isolated cleft palate

31

Allori AC et al. Classification of Cleft Lip/Palate: Then and Now. Cleft Palate–Craniofacial Journal 2016;53(1)
Davis and Ritchie’s classification (1922)

Group I: Prealveolar process cleft (clefts affecting the lip)


1. Unilateral (right/left: complete/incomplete)
2. Bilateral (right: complete/incomplete; left: complete/incomplete)
3. Median (complete/incomplete)

Group II: Postalveolar process cleft (clefts affecting the palate)


1. Soft palate
2. Hard palate

32

Allori AC et al. Classification of Cleft Lip/Palate: Then and Now. Cleft Palate–Craniofacial Journal 2016;53(1)
Group III: Alveolar process cleft (any cleft involving the alveolar
process)
1. Unilateral (right/left: complete/incomplete)
2. Bilateral (right: complete/incomplete; left: complete/incomplete)
3. Median (complete/incomplete)

33

Allori AC et al. Classification of Cleft Lip/Palate: Then and Now. Cleft Palate–Craniofacial Journal 2016;53(1)
Victor Veau’s classification (1931)

A] Cleft lip

Class I : U/L notching of vermillion border, not extending into the lip.
Class II : cleft extending into the lip, but not including the floor of the nose.
Class III: extending into the floor of the nose.
Class IV: any b/l cleft of the lip, whether incomplete or complete.

34

Allori AC et al. Classification of Cleft Lip/Palate: Then and Now. Cleft Palate–Craniofacial Journal 2016;53(1)
35

Allori AC et al. Classification of Cleft Lip/Palate: Then and Now. Cleft Palate–Craniofacial Journal 2016;53(1)
B] Cleft palate

Class I : soft palate


Class II : soft/hard palate extending no further than incisive foramen.
Class III: complete unilateral cleft, extending from uvula to incisive
foramen, then deviating to one side
Class IV: two clefts extending forward from the incisive foramen into the
alveolus.

36

Allori AC et al. Classification of Cleft Lip/Palate: Then and Now. Cleft Palate–Craniofacial Journal 2016;53(1)
37

Allori AC et al. Classification of Cleft Lip/Palate: Then and Now. Cleft Palate–Craniofacial Journal 2016;53(1)
Fogh-Andersen’s classification (1942)

1. H arelip (single or double)

2. H arelip with cleft palate

3. Isolated cleft palate

4. R are atypical clefts, e.g., median cleft lip

38

Allori AC et al. Classification of Cleft Lip/Palate: Then and Now. Cleft Palate–Craniofacial Journal 2016;53(1)
Kernahan and Stark’s classification (1958)

1. Clefts of structures anterior to the incisive foramen

2. Clefts of structures posterior to the incisive foramen

3. Clefts affecting structures anterior and posterior to the incisive


foramen

39

Allori AC et al. Classification of Cleft Lip/Palate: Then and Now. Cleft Palate–Craniofacial Journal 2016;53(1)
American Cleft Palate–Craniofacial Association (ACPA)
classification (1962)

1. Clefts of the prepalate (cleft of lip and embryologic primary palate)


a. Cleft lip (cheiloschisis)
b. Cleft alveolus (alveoloschisis)
c. Cleft lip, alveolus, and primary palate (cheiloalveoloschisis)

2. Clefts of the palate (cleft of the embryologic secondary palate)


a. Cleft of the hard palate (uranoschisis)
b. Cleft of the soft palate (staphyloschisis or veloschisis)
c. Cleft of the hard and soft palate (uranostaphyloschisis)
40

Allori AC et al. Classification of Cleft Lip/Palate: Then and Now. Cleft Palate–Craniofacial Journal 2016;53(1)
3. Clefts of the prepalate and palate (alveolocheilopalatoschisis)

4. Facial clefts other than prepalatal and palatal


a. Cleft of the mandibular process
b. Naso-ocular clefts
c. Oro-ocular clefts
d. Oroaural clefts

41

Allori AC et al. Classification of Cleft Lip/Palate: Then and Now. Cleft Palate–Craniofacial Journal 2016;53(1)
Kernahan and Stark’s stripped Y classification (1971)

42

Allori AC et al. Classification of Cleft Lip/Palate: Then and Now. Cleft Palate–Craniofacial Journal 2016;53(1)
Spina’s classification (1973)

Group I: Preincisive foramen clefts


a. Unilateral
b. Bilateral
c. Medial
Group II: Transincisive foramen clefts
a. Unilateral
b. Bilateral
Group III: Post incisive foramen clefts
a. Total
b. Partial
Group IV: Rare facial clefts
43

Allori AC et al. Classification of Cleft Lip/Palate: Then and Now. Cleft Palate–Craniofacial Journal 2016;53(1)
Kernahan and Stark’s
stripped-Y:
Modification by Ehlsaky
(1973) and Millard
(1976)

44
Schuchardt and Pfeifer’s symbolic classification
left Right

Lip

Alveolus

Hard palate

Partial
Soft palate
Total cleft

45

Allori AC et al. Classification of Cleft Lip/Palate: Then and Now. Cleft Palate–Craniofacial Journal 2016;53(1)
LAHSHAL classification by Okriens (1987)

 Lahshal is a paraphrase of the anatomic areas affected by the


cleft.
L – lip
A – alveolus
H – hard palate
S – soft palate
H – hard palate
A – alveolus
L – lip

46

Allori AC et al. Classification of Cleft Lip/Palate: Then and Now. Cleft Palate–Craniofacial Journal 2016;53(1)
DIAGNOSIS
DIAGNOSIS
• Prenatal ultrasound – 2D or 3D

• Prenatal counselling

• 22% to 33% rates for detecting facial clefts

• 73% - fetal cleft lip

• 1.4% - isolated cleft palate

• Color Doppler ultrasonography can also be used

48

Graber Vanarsdall and Vig. Orthodontics: Current Principles and Techniques. Elsevier 2012
Ultrasound technique

- Non-invasive diagnostic tool


- Confirm fetal viability
- Determine gestational age
- Establish number of fetuses and their growth
- Check placental location
- Examine fetal anatomy for detecting malformations

49

Graber Vanarsdall and Vig. Orthodontics: Current Principles and Techniques. Elsevier 2012
Transabdominal US
- Not reliable till gestational age of 15 weeks
- Done at 20 or more weeks of gestation

Transvaginal USG
- Earlier visualization (12 weeks)
- Better image resolution
- Greater specificity and sensitivity

50

Graber Vanarsdall and Vig. Orthodontics: Current Principles and Techniques. Elsevier 2012
Babcock and McGahan (1997)

- Starts with coronal plane

- Assessment continues in axial view

- Bilateral clefts: sagittal view

- Isolated clefts: axial view

51

Graber Vanarsdall and Vig. Orthodontics: Current Principles and Techniques. Elsevier 2012
Advantages of prenatal cleft diagnosis

- Psychological preparation for parents to have realistic expectations

- Parent education for cleft management

- Preparation for neonatal care and feeding

- Opportunity to investigate other abnormalities

- Possibility of fetal surgery

52

Graber Vanarsdall and Vig. Orthodontics: Current Principles and Techniques. Elsevier 2012
Disadvantages of prenatal cleft diagnosis

- Emotional disturbance

- High maternal anxiety and dysfunction

- Termination of pregnancy

53

Graber Vanarsdall and Vig. Orthodontics: Current Principles and Techniques. Elsevier 2012
PROBLEMS ASSOCIATED
WITH CLEFT LIP & PALATE
Dental

Skeletal

Nasal

Feeding

Ear problems

Speech

Associated anomalies

55

*Jamal GA et al. Prevalence of Dental Anomalies in a Population of Cleft Lip and Palate Patients. Cleft Palate–Craniofacial Journal, 2010;47(4):413-20
DENTAL

 Tooth agenesis, hypodontia (most common)

 Supernumerary teeth (2nd most common)

 Enamel hypoplasia (CI)

 Crossbites

 Ectopic eruption, transposition

 Taurodontism, dilacerations

56

*Jamal GA et al. Prevalence of Dental Anomalies in a Population of Cleft Lip and Palate Patients. Cleft Palate–Craniofacial Journal, 2010;47(4):413-20
SKELETAL

 Maxillary deficiency

 Mandibular prognathism

 Class III malocclusion

 Concave profile

57
*Ana Paula Ramos Bernardes da Silva, Beatriz Costa, Cleide Felício de Carvalho Carrara, Dental Anomalies of Number in The Permanent Dentition of Patients
With Bilateral Cleft Lip: Radiographic Study, The Cleft Palate-Craniofacial Journal. 2008;45(5):473-476.
FEEDING PROBLEMS

 Oronasal fistulas

 Draining of oral fluids in nasal cavity and vice versa

 Bottle, cup and spoon, tube feeding

 Infant held at 30-450 angle to aid swallowing

58
SYNDROMES ASSOCIATED
WITH CLEFT LIP & PALATE
SYNDROMES
 Around 400 syndromes

 Chromosomal anomalies
• Trisomy 13 (Patau)

• Trisomy 18 (Edward)

• Trisomy 21 (Down’s)

• Velocardiofacial syndrome (22q11 deletion)

60

*Sommerland BC. Management of cleft lip and palate. Current Paediatrics 1994
 Inherited syndrome
• Sticklers (Autosomal dominant)

• Treacher Collins (AD)

• Van der Woude (AD)

 Non-inherited syndrome
• Pierre Robin Syndrome – triad of cleft
palate, glossoptosis, retrognathia

• Goldenhar syndrome

61

*Sommerland BC. Management of cleft lip and palate. Current Paediatrics 1994
 Teratogenic
• Fetal alcohol syndrome

• Fetal phenytoin syndrome

• Fetal valproate syndrome

62

*Sommerland BC. Management of cleft lip and palate. Current Paediatrics 1994
MANAGEMENT OF CLEFT LIP
& PALATE
MULTIDISCIPLINARY MANAGEMENT

Dentist
ENT/
Surgeon
audiologist

Speech
Nursing
therapist
CLEFT
TEAM
Paediatrician Genecists

Psychologi Social
st worker
Ophthalmol
ogist 64
TIMING AND SEQUENCING OF CONSERVATIVE
SURGICAL-ORTHODONTIC TREATMENT (1980s)

65

*Berkowitz S. A Comparison of Treatment Results in Complete Bilateral Cleft Lip and Palate Using a Conservative Approach Versus Millard-Latham PSOT Procedure. Semin Orthod 1996;2:169-184
66

*Berkowitz S. A Comparison of Treatment Results in Complete Bilateral Cleft Lip and Palate Using a Conservative Approach Versus Millard-Latham PSOT Procedure. Semin Orthod 1996;2:169-184
Philadelphia Centre for research in Child growth-
Wilton Krogman (1947-71)

Divided the treatment into 8 phases:

• First stage – Prenatal phase


Complete history of gestation and maternal health, counseling of the parents

Genetisist and other Social workers

67
• Second stage – at birth
Pediatrician discusses the condition with the parents,

Surgeon advises about the operative plan,

Dental specialists appraises the arch relationships

• Third stage – birth to 1 year


Pediatrican - advises about the feeding

Surgeon - carries out the lip closure (rule of 10)

Dental specialist - secures the models and radiographs

Speech therapist - discusses about the insufficiency and incompetence of the


68
pharyngeal seal
• Fourth stage – 1-2yrs
Pediatrican - takes care of the health and nutrition.

Surgeon carries out the closure of the hard palate 1:2 soft palate 1:6

Speech therapist - monitors the vocabulary and option of a prosthetic


replacement

ENT - monitors the ear condition.

• Fifth stage – 2-6 years


Orthodontist – arch relations, crossbites, developing malocclusion

69
• Sixth stage – 6-12 years
Surgical corrections - secondary closure /repair of palate, lip and the nose

• Seventh stage – 12-18 years


Surgical follow up on the lip and nose correction, orthodontic treatment is
continued

• Eighth stage – 12 years onwards


Regular patient follow-up

70
Cleft Lip and Palate Patients Management in OSLO-
Norway (1948)

1. No preoperative orthopedics.

2. Closure of Cleft lip in infancy – Millard procedure -3 months

3. Closure of the remaining isolated cleft – Von Langenbeck -18


months.

4. Secondary operations 18-30 yrs of age.

71
FISHMAN

1. Pre dental treatment-1-18 months of age.

2. Deciduous dentition 3-6 yrs of age-full eruption of primary dentition.

3. Early mixed dentition 7-9 yrs- after or during the eruption of


permanent maxillary incisors.

4. Late mixed and early permanent dentition 9 ½ yrs onwards

72
PROFITT

1. Infancy – before the initial surgical repair of the lips.

2. During late primary and early mixed dentition.

3. Late mixed and early permanent dentition.

4. Late teens (after completion of facial growth in conjunction with


orthognathic surgery).

73
74

*Samuel Berkowitz. Celft Lip and Palate. 2006. 2nd edition Page number 451-8.
Neonatal • Birth to 1 year

Deciduous • 1 to 6 years
dentition

Mixed • 6 to 12 years
deentition

Permanent • 12 years
dentition and adult
75
NASOALVEOLAR MOULDING

• Hoffman (1678) – extraoral devices to retract protruding premaxilla

• McNeil (1950s) – presurgical orthopaedic

• Hotz – premaxilla is normally placed, by age 10, face grows


downward and forward into balance with premaxilla

76

*Samuel Berkowitz. Celft Lip and Palate. 2006. 2nd edition Page number 451-8.
• Grayson (1993) – first technique to correct the alveolus, lip and
nose in cleft infants

• Matsuo (1988)
- Research for cartilage moulding

- high maternal level of estrogen at the time of birth correlates with an


increase in hyaluronic acid, which inhibits the linking of the cartilage
intercellular matrix

77

*Samuel Berkowitz. Celft Lip and Palate. 2006. 2nd edition Page number 451-8.
• Matsuo used a stent, silicone tubes to shape the nostrils

• Grayson (1999) adapted his nasal stent to extend from the anterior
flange of an intraoral molding plate.

• This new technique was named – “ Nasoalveolar molding”

78

*Samuel Berkowitz. Celft Lip and Palate. 2006. 2nd edition Page number 451-8.
Objectives:

• Reduce severity of initial cleft deformity

• Columella – Nonsurgical lengthening (in bilateral clefts) and uprighting (in


unilateral clefts)

• Reduction in the width of the alveolar cleft segments until passive contact
of the gingival tissues is achieved.

79

*Samuel Berkowitz. Celft Lip and Palate. 2006. 2nd edition Page number 451-8.
Procedure:

• A heavy-bodied impression material is used to take the initial


impression as soon after birth as possible.

• Grayson and Maull (1999) held infant in upside down position to


keep the tongue forward which permitted fluids to draw off the oral
cavity when impression tray is placed

• Yang (2003) took the impression using a pre-trimmed customized


pediatric tray with the baby being held in the erect position,
by one of the parents
80

*Samuel Berkowitz. Celft Lip and Palate. 2006. 2nd edition Page number 451-8.
• Prashanth (2013), Mishra (2010) obtained impression when the infant
was awake in a prone position on the dental chair, the child is held
on the lap of their parents with no anesthesia.

• Dubey (2011) made impression of the cleft region upper arch using
ice cream stick and impression compound.

81

*Samuel Berkowitz. Celft Lip and Palate. 2006. 2nd edition Page number 451-8.
• Plate – clear self-cure acrylic, trimmed with a denture soft material

• 2–3 mm in thickness

• The retention arm – 40 degrees to get appropriate activation and to


avoid dislodgement of the NAM plate from palate

82

*Samuel Berkowitz. Celft Lip and Palate. 2006. 2nd edition Page number 451-8.
• The nasal stent is added to the intraoral molding plate when the
cleft alveolar gap is reduced to 5mm or less

• Stent – 0.036-in gauge round stainless steel wire

• The intranasal portion is formed from hard acrylic, covered with a


thin layer of soft spongy acrylic denture liner

83

*Samuel Berkowitz. Celft Lip and Palate. 2006. 2nd edition Page number 451-8.
• Elastics used are 0.25 inch and it should be stretched about two
times the diameter for activation force of about 2 Oz

84

*Samuel Berkowitz. Celft Lip and Palate. 2006. 2nd edition Page number 451-8.
85

*Samuel Berkowitz. Celft Lip and Palate. 2006. 2nd edition Page number 451-8.
Complications and disadvantages:

• Irritation of the oral mucosal or gingival tissue

• Ulceration of intraoral tissues

• The intranasal lining of the nasal tip can become inflamed

• Skin irritation due to tape usage

• Parent compliance required

• Moulding plate may get dislodged and obstruct the airway

86

*Samuel Berkowitz. Celft Lip and Palate. 2006. 2nd edition Page number 451-8.
Benefits:

• Short-term: the tissues are well aligned prior to primary lip and nose
repair

• Long-term:
• change in nasal shape is stable

• Reduced number of surgical revisions

• Reduction of treatment cost

• Shetty V et al (2017) - improves arch symmetry and stability, and thus


may prevent arch collapse in the long term
87

*Samuel Berkowitz. Celft Lip and Palate. 2006. 2nd edition Page number 451-8.
CLEFT LIP REPAIR

• Goal: improve facial aesthetics by restoring nasal and lip contour

• Timing: 3 to 6 months

• Millards “RULE OF TEN”


[term coined by Wilhelmmesen and Musgrave in 1969]
• 10 weeks (age)

• 10 pounds (weight)

• 10 gm/dl (Hb)
88
Techniques:

1. Tennison – Randall (Z-Plasty)

2. Millards rotation advancement repair

3. Rose – Thompson straight line repair

89
PRESURGICAL ORTHOPEDIC TREATMENT

Presurgical orthopedic treatment (PSOT) ?????

 Many authors – many minds

 PSOT beneficial or not ??

90

*Berkowitz S. A Comparison of Treatment Results in Complete Bilateral Cleft Lip and Palate Using a Conservative Approach Versus Millard-Latham PSOT Procedure. Semin Orthod 1996;2:169-184
 1920s -1930s – repair the defect by establishing an anatomical
continuity

 Priority of treatment
- Improve speech ability

- Dental function

- Facial aesthetics

 Importance of growth not recognized


91

*Berkowitz S. A Comparison of Treatment Results in Complete Bilateral Cleft Lip and Palate Using a Conservative Approach Versus Millard-Latham PSOT Procedure. Semin Orthod 1996;2:169-184
 1950s – Two schools of thoughts

• McNeil and Burston


Presurgical • Align palatal segments
Orthopedics • Delay palatal closure till 5-9 years
of age

• Led by Pruzansky
Immediate • Did not favour PSOT
surgery • Palatal closure at 2-4 years of age

92

*Berkowitz S. A Comparison of Treatment Results in Complete Bilateral Cleft Lip and Palate Using a Conservative Approach Versus Millard-Latham PSOT Procedure. Semin Orthod 1996;2:169-184
A Millard-Latham Procedure

 Latham manipulated the palatally pinned presurgical


orthopaedic appliance – mechanical expansion of the
lateral palatal segments is followed by the retraction of the
protruding premaxilla into position within the arch

 Floor of nose is surgically closed

 Gingivoperiosteoplasty – migration of alveolar bone cells –


close alveolar gap

93

*Berkowitz S. A Comparison of Treatment Results in Complete Bilateral Cleft Lip and Palate Using a Conservative Approach Versus Millard-Latham PSOT Procedure. Semin Orthod 1996;2:169-184
 Modified appliance – a premaxillary stainless steel
pin 7/10 mm in diameter is inserted through the
posterior stem of the premaxilla.

 3 Oz force per side for premaxilla retraction

 Premaxilla retraction and expansion

 8-14 days – premaxilla is positioned within the


palatal segments

94

*Berkowitz S. A Comparison of Treatment Results in Complete Bilateral Cleft Lip and Palate Using a Conservative Approach Versus Millard-Latham PSOT Procedure. Semin Orthod 1996;2:169-184
CHANGING SURGICAL CONCEPT FROM 1920S TO
1950S

• Graber (1950s) – surgery performed early, caused severe midfacial


deformity later

• Brophy, first proponent of surgical technique – steel-clamp and


silver-wire bony closure technique

• von Langenback soft tissue procedure alone to approximate lateral


halves of maxilla and reduce intermaxillary width

95

*Berkowitz S. A Comparison of Treatment Results in Complete Bilateral Cleft Lip and Palate Using a Conservative Approach Versus Millard-Latham PSOT Procedure. Semin Orthod 1996;2:169-184
• Graber, Slaughter and Brodie (1950s-1960s) – negative reports on
surgical procedure done at an early age

• “No palatal surgery at an early age” (before 12 months)

• James Scott (1956) – Sutural growth theory

• McNeil and Burston – adopted his theory – functional paediatric


prosthesis – palatal closure between 5 to 9 years of age

96

*Berkowitz S. A Comparison of Treatment Results in Complete Bilateral Cleft Lip and Palate Using a Conservative Approach Versus Millard-Latham PSOT Procedure. Semin Orthod 1996;2:169-184
• Melvin Moss (1968) – functional matric theory – septal cartilage
grows as a secondary response

• McNeil – Father of presurgical orthopaedics – supported Scott’s


theory

• Burston – premaxilla was normal and lateral palatal segments were


retruded in face

• Presurgical orthopaedics + primary bone grafting within first year of


life

• Prusanky – opposed the same


97

*Berkowitz S. A Comparison of Treatment Results in Complete Bilateral Cleft Lip and Palate Using a Conservative Approach Versus Millard-Latham PSOT Procedure. Semin Orthod 1996;2:169-184
CLAIMED BENEFITS OF PSOT

• Control and modify postnatal development of maxilla

• Early alignment for better occlusion and function – swallowing and


speech

• Reduce middle ear infections

98

*Berkowitz S. A Comparison of Treatment Results in Complete Bilateral Cleft Lip and Palate Using a Conservative Approach Versus Millard-Latham PSOT Procedure. Semin Orthod 1996;2:169-184
• Berkowitz (1978) – “State of art”

• Primary bone grafting – deleterious effects on midface

• No evidence that PSOT normalize feeding, tongue posture,


swallowing or growth

99

*Berkowitz S. A Comparison of Treatment Results in Complete Bilateral Cleft Lip and Palate Using a Conservative Approach Versus Millard-Latham PSOT Procedure. Semin Orthod 1996;2:169-184
CONSERVATIVE TREATMENT – THE BEST APPROACH

• Same surgery performed can cause in different results at different


ages:
1. The cleft defect

2. The facial growth pattern

3. The surgical procedure

100

*Berkowitz S. A Comparison of Treatment Results in Complete Bilateral Cleft Lip and Palate Using a Conservative Approach Versus Millard-Latham PSOT Procedure. Semin Orthod 1996;2:169-184
CLEFT PALATE SURGERY TIMING AND SPEECH
OUTCOME

1970s

• Mid to late 1970’s – 18 to 24 months surgical palate repair

• General trend of better speech results with earlier ages at surgery

• Jolleys (1954) – approximately 90% of children who underwent


surgery before the age of 2 years had good or excellent speech

• General age range for surgery – 6-9 months, before 8 months, 1


year range, between 2 to 3 years
101

*Peterson S. The Relationship Between Timing of Cleft Palate Surgery and Speech Outcome: What Have We Learned, and Where Do We Stand in the 1990s? Semin Orthod 1996;2:185-191
1980 – 1990s

• Kaplan (1981) – palatal closure between age of 3 to 6 months

• Dorf and Curtin (1982,1990) – importance for phonemic


development or articulation age

• Greater discrepancy in speech performance between the "12


months and younger group" and the children operated on over the
age of 12 months

• Ross (1987) – slightly better facial growth if surgery done in the first
year of life

102

*Peterson S. The Relationship Between Timing of Cleft Palate Surgery and Speech Outcome: What Have We Learned, and Where Do We Stand in the 1990s? Semin Orthod 1996;2:185-191
SURGERIES FOR CLEFT PALATE

1. Von Langenback

2. V-Y palatoplasty by Veau

3. Furlow’s technique

4. Wardill Kilner’s push back

103
BONE GRAFTING FOR ALVEOLAR CLEFT
DEFECTS

BONE
GRAFTING

Primary Secondary
bone bone
grafting grafting

First 2 years of Early – 2 to 5 Late – 11 to 14


life years of life years of life
104

*Waite P, Waite D. Bone Grafting for the Alveolar Cleft Defect. Semin Orthod 1996;2:192-196
OBJEVTIVES FOR SURGICAL GRAFTING:

• Stabilization of segments

• Improved oral hygiene

• Nasal secretions prevented from draining into the mouth

• Unites maxilla to better withstand occlusal forces

• Bony base for teeth eruption

• Improves nasal symmetry

• Provide feeling of normalcy and improve social acceptance

105

*Waite P, Waite D. Bone Grafting for the Alveolar Cleft Defect. Semin Orthod 1996;2:192-196
BONE GRAFTING AND ORTHODONTIC TOOTH MOVEMENT

• A general rule – “orthodontic tooth movement performed with


improved outcomes after the bone graft has been completed”

• Tooth movement initiated 1 to 3 months after grafting into the grafted


area

106

*Waite P, Waite D. Bone Grafting for the Alveolar Cleft Defect. Semin Orthod 1996;2:192-196
SURGICAL MANAGEMNT OF ALVEOLAR CLEFT

• Ideal timing:
- 9 to 11 years of age
- Before canine eruption, canine root is 1/3rd formed (Bergland et al)

• Best source of bone graft: (autologous cancellous bone)


- Anterior portion of iliac crest
- The rib, tibia
- The cranium
- The mandible

107

*Waite P, Waite D. Bone Grafting for the Alveolar Cleft Defect. Semin Orthod 1996;2:192-196
108
ROLE OF ORTHODONTIST

109

*Vlachos C. Orthodontic Treatment for the Cleft Palate Patient. Semin Orthod 1996;2:197-204.
A] NEONATAL MAXILLARY ORTHOPAEDICS

• McNeil (1950)s – Father of presurgical orthopaedics

• Rationale – realignment of collapsed segments

• Active or passive orthopaedic appliances

110

*Vlachos C. Orthodontic Treatment for the Cleft Palate Patient. Semin Orthod 1996;2:197-204.
B] ORTHODONTIC-ORTHOPAEDIC TREATMENT IN DECIDUOUS
DENTITION

• Problems in deciduous dentition:


- Delay in eruption in vicinity of cleft

- Malformed or congenitally missing lateral incisor

- Anterior or posterior buccal crossbite

- Functional shift

111

*Vlachos C. Orthodontic Treatment for the Cleft Palate Patient. Semin Orthod 1996;2:197-204
• Turvey (1982) believe that orthodontic treatment in the deciduous
dentition, although possible, is contraindicated

• Rygh and Tindlund (1988) – Growth modification at this stage has


been proposed

• They recommend utilization of a quad-helix appliance soldered to


bands on the primary second molar teeth and canines to expand the
upper arch

• Alongwith protraction face mask to modify and redirect growth

112

*Vlachos C. Orthodontic Treatment for the Cleft Palate Patient. Semin Orthod 1996;2:197-204.
C] ORTHODONTIC TREATMENT DURING THE MIXED DENTITION

• Bone grafting:
• 5 to 6 years of age

• After 8 to 9 years of age

• Radiographically, after root of unerupted canine is half or one-third developed.

113

*Vlachos C. Orthodontic Treatment for the Cleft Palate Patient. Semin Orthod 1996;2:197-204
• Orthodontics – 6 months before grafting

• Fixed appliance in upper arch

• Objectives at this stage:


- Expansion of maxilla,

- elimination of crossbites, derotations of malposed teeth,

- improve dental and aesthetic function

• Spontaneous canine eruption (27%), surgical uncovering (17%),


combined surgical and orthodontic traction (56%)

• Orthodontics resumed 3 months after graft placement

114

*Vlachos C. Orthodontic Treatment for the Cleft Palate Patient. Semin Orthod 1996;2:197-204.
Expansion appliances for cleft palate patients:

1. Telescopic maxillary expander

2. Fan shaped maxillary expander

3. Butterfly maxillary expander

4. Spring jet for slow expansion

5. Banded / bonded rapid palatal expansion

6. Modified hyrax appliance

7. Quad helix
115
Protraction Facemask Therapy:

• Can be used before bone grafting in mild midfacial deficiency

• Increased growth at circumaxillary sutures

• Orthopaedic force – 350 to 500 gram/side

• 10-12 hours a day

• 12-15 months

116
D] ORTHODONTIC TREATMENT DURING THE PERMANENT
DENTITION

• Decision – orthodontics alone OR orthodontic combined with


orthognathic surgery

• Ross (1987) – 25% require surgery

• 3 consecutive cephalogram, 6 months apart showing no change in


length of mandible can be used

117

*Vlachos C. Orthodontic Treatment for the Cleft Palate Patient. Semin Orthod 1996;2:197-204.
TREATMENT BY ORTHODONTICS ALONE

1. Tooth alignment

2. Establishment of a continuous maxillary arch with favourable archform

3. Correction of anterior and/or posterior crossbites

4. Stability of occlusion in the presence of dental compensations

5. Favourable dentofacial esthetics

118

*Vlachos C. Orthodontic Treatment for the Cleft Palate Patient. Semin Orthod 1996;2:197-204.
TREATMENT BY ORTHODONTICS COMBINED WITH
ORTHOGNATHIC SURGERY

• Severe skeletal discrepancy, oronasal fistulas, speech deformity

• Maxillary surgery – multiple segment Le Fort I osteotomy with down-


grafting

• Presurgical orthodontic treatment – 12 months

• AP discrepancy – more than 8mm – bijaw surgery needs to be


planned
119

*Vlachos C. Orthodontic Treatment for the Cleft Palate Patient. Semin Orthod 1996;2:197-204.
• Unilateral clefts – 2 piece Le Fort I osteotomy

120

*Posnick J. Orthognathic Surgery for the Cleft Lip and Palate Patient. Semin Orthod 1996;2:205-14
• Bilateral clefts – 3 piece Le Fort I osteotomy

121

*Posnick J. Orthognathic Surgery for the Cleft Lip and Palate Patient. Semin Orthod 1996;2:205-14
• Post-surgical orthodontic – 4 to 6 months

• Transverse maxillary stabilization by transpalatal arch or piggy-back


overlay arches

• Immediate retainers – Hawley’s type

• Cemented lingual arch in maxilla

• Vaccum formed retainers not indicated

122

*Vlachos C. Orthodontic Treatment for the Cleft Palate Patient. Semin Orthod 1996;2:197-204.
PROSTHETIC REHABILITATION FOR CLEFT PALATE
PATIENTS

• Ambrose Pare (1565) – prosthesis to obturate palate

• Obturators using sponges, wax, and silver to more modern


materials

• Latham appliance (1980) – unilateral or bilateral clefts

123

*Gardener LK, Parr GR. Prosthetic Rehabilitation of the Cleft Palate Patient. Semin Orthod 1996;2:215-19
Restorative treatment options in permanent dentition

• Partial overdenture

• Removable partial dentures

• Fixed prosthetic rehabilitation

• Implant prosthodontics

• Restoration – laminates and veneers

124

*Gardener LK, Parr GR. Prosthetic Rehabilitation of the Cleft Palate Patient. Semin Orthod 1996;2:215-19
VELOPHARYNGEAL IMPAIRMENT

 Velopharyngeal impairment – insufficient contact


between the velum and the posterior and lateral
pharyngeal walls

 Velopharyngeal insufficiency – deficiency

 Velopharyngeal incompetence – neuromuscular

125

*Dalston R. Velopharyngeal Impairment in the orthodontic patients. Semin Orthod 1996;2:220-7.


Treatment

1. Speech therapy

2. Non-surgical or speech aid prosthesis

• Obturators

• Transitional appliance in growing patients

3. Surgical

• Palatoplasty, Sphincter pharyngeoplasty

126

*Gardener LK, Parr GR. Prosthetic Rehabilitation of the Cleft Palate Patient. Semin Orthod 1996;2:215-19
RECENT ADVANCES

• Fetal surgery – done in intrauterine life (prior to 20 weeks)

• Non-life threatening defects like cleft lip, cleft palate, Pierre Robin
syndrome, Treacher-Collins syndrome, craniofacial microsomia

• Open fetal surgery

• Feto-endoscopic approach

127

*Papadopulos NA. Foetal surgery and cleft lip and palate: current status and new perspectives. Br J Plast Surg. 2005 Jul;58(5):593-607
ADVANTAGES

1. Provide a scarless repair, “ripple effect” is eliminated

2. Correct the primary deformity,

3. Prevent secondary deformities, and

4. Give the parents a "normal“ - appearing child at birth

128

*Papadopulos NA. Foetal surgery and cleft lip and palate: current status and new perspectives. Br J Plast Surg. 2005 Jul;58(5):593-607
CONCLUSION
• Oral clefts are the second most common congenital anamoly, having
multifactorial origin

• A considerable knowledge about the etiology and embryology is


required for proper diagnosis and treatment planning of such patients

• Treatment begins soon after birth and continues till adulthood


requiring a team approach.

129
CONCLUSION

• Multiple problems and syndromes with clefts

• Multidisciplinary approach for management, patient-centered

• Variations in treatment sequence

• Role of orthodontists

130
REFERENCES
• Reddy S et al. Incidence of cleft Lip and palate in the state of Andhra
Pradesh, South India. Indian J Plast Surg. 2010 Jul-Dec; 43(2): 184–9.
• Allori AC et al. Cleft lip and palate classification: Then and Now. Cleft
Palate–Craniofacial Journal 2016;53(1)
• Graber Vanarsdall and Vig. Orthodontics: Current Principles and
Techniques. Elsevier 2012.
• John B. Thornton, Sue Nim Paul S. Howard. The incidence, classification,
etiology and embryology of oral clefts. Semin Orthod 1996;2:162-168
• Inderbir Singh. Human embryology. Macmillan India. Seventh edition 2001.
• Peter Mosby et al. Cleft Lip and Palate. Lancet 2009; 374: 1773–85

131
REFERENCES
1. Graber Vanarsdall and Vig. Orthodontics: Current Principles and Techniques. Elsevier 2012
2. Jamal GA et al. Prevalence of Dental Anomalies in a Population of Cleft Lip and Palate
Patients. Cleft Palate–Craniofacial Journal, 2010;47(4):413-20
3. Ana Paula Ramos Bernardes da Silva, Beatriz Costa, Cleide Felício de Carvalho Carrara,
Dental Anomalies of Number in The Permanent Dentition of Patients With Bilateral Cleft Lip:
Radiographic Study, The Cleft Palate-Craniofacial Journal. 2008;45(5):473-476.
4. Sommerland BC. Management of cleft lip and palate. Current Paediatrics 1994
5. Berkowitz S. A Comparison of Treatment Results in Complete Bilateral Cleft Lip and Palate
Using a Conservative Approach Versus Millard-Latham PSOT Procedure. Semin Orthod
1996;2:169-184
6. Peterson S. The Relationship Between Timing of Cleft Palate Surgery and Speech
Outcome: What Have We Learned, and Where Do We Stand in the 1990s? Semin Orthod
1996;2:185-191

132
7. Samuel Berkowitz. Celft Lip and Palate. 2006. 2nd edition Page number 451-8.
8. Waite P, Waite D. Bone Grafting for the Alveolar Cleft Defect. Semin Orthod 1996;2:192-
196
9. Vlachos C. Orthodontic Treatment for the Cleft Palate Patient. Semin Orthod 1996;2:197-
204
10. Posnick J. Orthognathic Surgery for the Cleft Lip and Palate Patient. Semin Orthod
1996;2:205-14
11. Gardener LK, Parr GR. Prosthetic Rehabilitation of the Cleft Palate Patient. Semin Orthod
1996;2:215-19
12. Dalston R. Velopharyngeal Impairment in the orthodontic patients. Semin Orthod
1996;2:220-7.
13. Papadopulos NA. Foetal surgery and cleft lip and palate: current status and new
perspectives. Br J Plast Surg. 2005 Jul;58(5):593-607
14. Chang J. Fetal plastic surgery: a review and preview. © Chang www.thefetus.net/

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THANK YOU
THANK YOU

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